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5Th Theodor Escherich & 2Nd AMICI Joint Symposium 5th Theodor Escherich & 2nd AMICI Joint Symposium 8th - 9th November 2018 Neuer Med Campus, Neue Stiftingtalstraße 2 Medical University of Graz, Austria ABSTRACT BOOK If you do’t like iroes, you’re o the rog plaet (Stewart Brand, adapted) In behalf of the organizing committee of the 5th Theodor Escherich & 2nd AMICI Joint Symposium 2018 we cordially welcome you at the Medical University of Graz. We are very pleased with the high number of renowned national and international scientists oerig the topis iroioe ad aer, iroioe ad utritio, iroioe ad eiroet, egleted eers of the hua iroioe, iroiota odulatio ad the plat iroioe that hae aepted our iitatio to speak. We will have more than 200 guests from Austria and Europe, interested interdisciplinary microbiome research. The new Campus at the Medical University in Graz provides an excellent venue for this event, and we are convinced that the wonderful atmosphere in this building will support personal exchange and discussion amongst young researchers and PIs. We are particularly thankful for the fruitful interaction with the Austrian Microbiome Initiative AMICI, serving as an excellent networking platform for microbiome research – resulting in this joint adventure this year! We are extremely grateful for the generous support from our sponsors and industry partners. We are looking forward to a very fruitful meeting, The local organizing committee Gabriele Berg Gregor Christoph Robert Krause, Christine Moissl- TU Graz Gorkiewicz, MUG Högenauer, MUG MUG Eichinger, MUG www.medunigraz.at/microbiome Sehr geehrte Damen und Herren, liebe Kolleginnen und Kollegen! Bakterien, Viren, Archaen, Parasiten und Pilze – unseren Körper teilen wir mit Billionen Bakterien, die Mundhöhle, Haut und Darm besiedeln. Rund eineinhalb Kilogramm unseres Körpergewichts macht das Mikrobiom aus. Das Wissen um die Relevanz des Mikrobioms für die Gesundheit unseres Körpers wurde in ihrer Bedeutung lange Zeit unterschätzt. Das hat sich mit der Entwicklung neuer Methoden vor rund 15 Jahren deutlich gewandelt. Mittlerweile ist die Erforschung des Mikrobioms ein sich rasch entwickelndes Forschungsfeld mit Relevanz für viele Bereiche unseres Lebens – von Humanmedizin, über Veterinärmedizin, Mikrobiologie, Umweltbiologie bis zur Toxikologie. In allen diesen Bereichen wurden wichtige Zusammenhänge mit dem Mikrobiom gefunden. Das diesjährige 5. Theodor-Escherich und 2. AMICI Symposium trägt dieser rasanten Entwicklung in mehrfacher Hinsicht Rechnung. Die gemeinsame Veranstaltung bringt Forscher aus unterschiedlichsten Bereichen zusammen für Wissensaustauch, Inspiration, Vernetzung und Schaffung von Synergien. Die Themen umfassen viele der derzeitigen „hot topics“ im Bereich der Mikrobiom- Forschung: Krebs & Mikrobiom, Mycobiom, Archaeom, Gastrointestinale Erkrankungen, Ernährung, Fäkale Mikrobiota-Transplantation und Pflanzenmikrobiom. Die Diversität der Themen reflektiert die bunte Vielfalt an Expertise, die sich in Graz versammelt zum Wissensaustauch. Posterpräsentationen und ausgewählte Vorträge zu aktuellen, österreichischen Forschungsergebnissen zeigen die positiven Entwicklungen in der Mikrobiomforschung zusätzlich auf. Ein Grundstein für diese erfreuliche Entwicklung in der österreichischen Mikrobiom-Forschungsgemeinschaft wurde vor 2 Jahren gelegt mit der Gründung der Austrian Microbiome Initiative (AMICI). AMICI verbindet neun unterschiedliche Fachgesellschaften, um Expertise in diesem Bereich zu bündeln und eine Plattform für den Wissens- und Ressourcenaustausch zu schaffen. Innerhalb dieser kurzen Zeit hat die neue Gesellschaft im In- und Ausland Anerkennung gefunden, hat Forscher bei der Entwicklung von Projekten und Beantragung von Forschungsförderungen unterstützt und das Thema für Laien bis zu Experten sichtbarer gemacht. Einen Überblick über die Aktivitäten und Expertise von AMICI finden Sie auf unserer Homepage (http://www.microbiome.at/de). Das zweite AMICI Symposium ist somit ein weiterer Schritt zur Vernetzung von Kollegen und Freunden im Bereich der Mikrobiomforschung. Ich freue mich, dieses Symposium mit ihnen zu verbringen! Prof. Dr. Christoph Steininger Präsident AMICI Program: 5th Theodor Escherich & 2nd AMICI Joint symposium on Medical Microbiome Research Thursday, 8 November 2018: morning 8.15- 9.00 Registration and set-up 9.00- 9.10 Lecture hall: Opening and welcome note 9.10- 10:10 Lecture hall: Session 1: Microbiome and cancer Chairs: Margit Neger & Buck Hanson 9.10 (30 min) INVITED: “Gut microbiota and colorectal cancer” Paul O`Toole, University College Cork, Ireland 9.40 (30 min) INVITED: “Microbes, Microbiota and Cancer” Julia Drewes, John Hopkins University, Baltimore, USA 10.10- 10:50 Lecture hall: Session 2: Nutrition and Environment I Chairs: Jovana Mihajlovic & Sabrina Mörkl 10.10 (20 min) INVITED: “Toxins and microbial metabolites in food: a Trojan horse?” Doris Marko, University of Vienna, Austria 10.30 (20 min) INVITED: “New functions of the core human microbiota: Metabolism of a vegetarian diet compound in the gut” Alexander Loy, University of Vienna, Austria 10.50- 11.20 Coffee break and posters 11.20- 12:50 Lecture hall: Session 3: Nutrition and Environment II Chairs: Markus Eder & Angela Horvath 11.20 (20 min) INVITED: “Intestinal microbiota and barrier: A trigger of aging?” Ina Bergheim, University of Vienna, Austria 11.40 (20 min) INVITED: “Studying interactions between herbal medicinal products and human gut bacteria” Eva Pferschy-Wenzig, University of Graz, Austria 12.00 SELECTED CONTRIBUTIONS (10 min each): “Prebiotic intervention with partially hydrolyzed guar gum (PHGG) – symptomatic, taxonomic and metabolomic outcomes from the prospective PAGODA trial” Simon Jakob Reider, Medical University Innsbruck, Austria “Complementary intestinal mucosa and microbiota responses to caloric restriction” Kalina Duszka, University of Vienna, Austria “Profiling the apple microbiome for health issues” Birgit Wassermann, Technical University Graz, Austria “Evaluating the selectivity of prebiotics: Inulin as a case study” Alessandra Riva, University of Vienna, Austria “Urinary and vaginal microbiome in premature labor” Manuela-Raluca Pausan, Medical University Graz, Austria 12.50- 14.50 Lunch break, posters and poster pitches 13.30 (~ 40 min) Lecture hall: Short presentation of posters: “Poster pitches” (1 min ea) Program: 5th Theodor Escherich & 2nd AMICI Joint symposium on Medical Microbiome Research Thursday, 8 November 2018: afternoon 14.50- 16:00 Lecture hall: Session 4: Neglected members of the human microbiome Chairs: Alexander Mahnert & Julian Taffner 14.50 (10 min) SELECTED CONTRIBUTION “The human archaeome”, Kaisa Koskinen, Medical University Graz, Austria 15.00 (30 min) INVITED: “Methanoarchaea as part of the human microbiome: Friends or Foes?” Ruth Schmitz-Streit, University of Kiel, Germany 15.30 (30 min) INVITED: “Microbiome/Bacteriome Interactions: Role in Health and Disease” Mahmoud Ghannoum, Case Western Reserve University, USA 16.00- 16.20 Coffee break and posters 16.20- 17:40 Lecture hall: Session 5: Microbiomes of humans and plants/various topics Chairs: Kaisa Koskinen & Vijaykumar Patra 16.20 (30 min) INVITED: “The inter-connected microbiome: from plants to human” Gabriele Berg, Technical University of Graz, Austria 16.50 SELECTED CONTRIBUTIONS (10 min each): “Plasmid DNA contaminant in molecular reagents” Christoph Steininger, Medical University of Vienna, Austria “Is the gut-lung axis bi-directional? Alternations of the gut microbiome in mice with allergic lung disease” Irma Schabussova, Medical University Vienna, Austria “Changes in the cutaneous microbiome in the course of allogeneic hematopoietic stem cell transplantation” Nadine Bayer, Medical University Vienna, Austria “Increased Staphylococcus aureus abundance in cutaneous squamous cell carcinoma confers microbial growth stimulus for tumor cells” Nanditha Madhusudhan, Medical University Graz, Austria “Antibiotic-associated secondary IGA-deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia” Oliver Robak, Medical University Vienna, Austria 17.40 End of day 1, closing remarks For invited speakers only: Speakers’ dinner Program: 5th Theodor Escherich & 2nd AMICI Joint symposium on Medical Microbiome Research 8.15- 9.00 Registration and set-up 9.00- 10:30 Lecture hall: Session 6: Microbiota-Modulation Chairs: Christoph Högenauer & Barbara Jelusic 9.00 (30 min) INVITED: “Stool banks for fecal donation - A necessity for the future” Josbert Keller, NDFB, The Netherlands 9.30 (20 min) INVITED: “Microbiota Modulation as a new treatment option for inflammatory bowel disease - ready for clinical practice?” Patrizia Kump, Christoph Högenauer, Medical University Graz, Austria 9.50 (20 min) INVITED: “How can we change the intestinal microbiota by fecal microbiota transplantation, antibiotics or probiotics?” Philip Wurm, Medical University Graz, Austria 10.10 SELECTED CONTRIBUTIONS (10 min each): “Microbiome, Molecular Clock and Mood in affective disorders” Susanne Bengesser, Medical University Graz, Austria “Immunomodulation of the Human Gut Microbiome via Bacterial Membrane Vesicles” Paul Kohl, University of Graz, Austria 10.30- 11.00 Coffee break and posters 11.00- 13:00 Lecture hall: Session 7: Plant microbiome Chairs: Wisnu Wicaksono & Lisa Krug 11.00 (20 min) INVITED: “The role of the seed microbiome of barley for plant performance” Michael Schloter, TU Munich, Helmholtz Center Munich, Germany 11.20 (20 min) INVITED: “Human pathogens in plant production systems” Leo van Overbeek, Wageningen
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