Lessons Learned: Milestones of Toxicology Steven G

Lessons Learned: Milestones of Toxicology Steven G. Gilbert1 and Antoinette Hayes2 1Institute of Neurotoxicology and Neurological Disorders and 2Northeastern University Contact information: Steven G. Gilbert at [email protected] – For more information, its interactive (clickable) at www.asmalldoseof.org – © 2006 Steven G. Gilbert

Shen Nung Ebers Papyrus Gula 1400 BCE Homer Socrates Hippocrates Mithridates VI L. Cornelius Sulla Cleopatra Pedanius Mount Vesuvius 2696 BCE 1500 BCE 850 BCE (470-399 BCE) (460-377 BCE) (131-63 BCE) 82 BCE (69-30 BCE) Dioscorides Erupted August 24th Antiquity The Father of Egyptian records Wrote of the Charged with Greek physician, Tested antidotes Lex Cornelia de Experimented (40-90 CE) 79 CE Chinese contains 110 use of arrows religious heresy observational to poisons on sicariis et with strychnine Greek City of Pompeii & 3000 BCE – 90 CE pages on anatomy Sumerian texts refer to a medicine, noted poisoned with venom in the and corrupting the morals approach to human disease himself and used prisoners veneficis –law and other poisons on pharmacologist and Herculaneum and physiology, toxicology, female deity, Gula. This for tasting 365 herbs and epic tale of The Odyssey of local youth. Death by and treatment, founder of as guinea pigs. Created against poisoning people or prisoners and poor. Physician,wrote De Materia destroyed and buried spells, and treatment, mythological figure was said to have died of a toxic and The Iliad. From Greek Hemlock - active chemical modern medicine, named mixtures of substances prisoners; could not buy, Committed suicide with Medica basis for the by ash. Pliny the Elder recorded on papyrus. associated with charms, overdose. toxikon arrow poison. alkaloid coniine. cancer after creeping crab. leading to term mithridatic. sell or possess poisons. Egyptian Asp. modern pharmacopeia. suffocated by volcanic gases. spells and poisons.

Greek Fire Ergot Outbreak Moses Maimonides Albertus Magnus Raymundus Lullius Knights Templars Petrus de Abano The Black Death Venetian Council of Zhou Man Rodrigo & 673 CE 994 CE (1135-1204) (1193-1280) 1275 (1118-1307) (1250-1315) (1347-1351) Ten - 1419 1423 Cesare Borgia Middle Ages Ancient 40,000 died Jewish Dominican friar Ether discovered Christian military Italian scholar Bubonic & Group of Chinese explorer (1400-1500) “napalm” described by the from eating philosopher & wrote extensively by Spanish order alleged to translated pneumonic people who lost 1000s of crew Poisoned many people in Italy 476 CE – 1453 Crusaders as consisting of contaminated wheat/rye physician wrote: on compatibility chemist and be experts with Hippocrates and plague ravaged Europe carried out members from uranium for political and monetary gain. naptha, quicklime, sulphur, caused gangrene - known as Treatise on Poisons and religion and science and later called poisons. They searched for Galen to Latin. Wrote book leaving the highest number murders with poison for a exposure while mining lead Used arsenic in a concoction & saltpeter. St. Anthony’s Fire. Their Antidotes. isolated arsenic in 1250. “sweet vitriol”. the “Elixir of Life”. on poisons: De Venenis. of casualties in history. fee. in Jabiru Australia. called “La Cantrella”.

Leonardo de Vinci Pope Clement VII Paracelsus Georgius Agricola Catherine Medici William Piso Shakespeare Hieronyma Spara Catherine Monvoisin Guilia Tophania King Louis XIV Renaissance (1452-1519) (1478-1534) (1493-1541) (1494-1555) (1519-1589) 1640 (1564-1616) ~1659 (LaVoisin) (1635-1719) 1682 Experimented with Died (possibly “All substances Wrote De Re Queen of France, In Brazil, From Romeo & Roman women & (1640-1680) Italian woman who Passed royal decree 14th–16th bioaccumulation of murdered) after are poisons; Metallica published expert assassin, studied effects Juliet - act 5 fortune teller Accused sorcerer supplied poison (arsenic) to forbidding apothecaries there is none which is not a poisons in animals eating amanita 1556. The most tested poisons of Cephaelis “Here’s to my love! O true organized wealthy wives and and convicted wives looking to murder to sell arsenic or poisonous poison. The right dose Centuries and called the procedure Phalloides, (death cap) comprehensive book on on the poor and Ipecacuanha, apothecary! Thy drugs are sold them a arsenic elixir to poisoner in France. their husbands. Later substances except to persons “passages”. differentiates a poison from a mining and metallurgy. murder their husbands. mushroom. remedy.” the sick. an emetic; treat dysentery. quick. Thus with a kiss I die.” She was burned at the stake. executed by strangulation. known to them.

Devonshire Colic John Jones Richard Meade Carl Wilhelm Percivall Pott Felice Fontana Freidrich Serturner Francoise Magendie Fowler’s Solution Pierre Ordinaire Mateu J.B. Orfila 1700’s 1701 (1673-1754) Scheele (1742-176) (1714-1788) 1767 (1783-1841) (1783-1855) 1786-1936 1797-1915 (1787-1853) Devonshire, English doctor wrote In 1702, wrote A Swedish apothecary British physician Italian chemist and Isolated an alkaloid Discovered emetine Potassium arsenite Created elixir Considered the father 1700s England. High The Mysteries of Opium Mechanical and chemist, who recognized physiologist who From opium poppy and studied effects solution prescribed using absinthe of modern toxicology. incidence of lead Reveal’d described many Account of Poisons discovered oxygen, coal-tar caused was the first to study in 1803. He named of strychnine & as a general tonic popularized and sold by Henry In 1813 he published colic drinking treatments of opium, but also dedicated to poisons snakes, barium, chlorine, cancer of the scrotum in venomous snakes. Discovered it Morphine after Morpheus, the cyanide. Called and used from about Pernod. Absinthe was used by Traite des Poisons, the father of contaminated cider. withdrawal and addiction. animals and plants. manganese, and chimney sweeps. Chimney that viper venom affects blood. Greek god of dreams. 1786 to 1936. Used Vincent Van Gogh; banned in which described the symptoms of hydrogen cyanide. Sweepers Act of 1788. experimental pharmacology. by Charles Darwin? 1915, subject of Degas. poisons.

Thomas de Quincey James Marsh Robert Christison Claude Bernard Ascanio Sobrero Theodore G. Wormley Joseph Caventou & Arsenic Act 1851 Louis Lewin Emil Fischer Constantine Fahlberg (1785-1859) (1794-1846) (1797-1882) (1813-1878) (1812- 1888) (1826-1897) Pierre Pelletier Required arsenic to be colored (1854-1929) 1852-1919 Saccharin - 1879 with soot or indigo to prevent English writer Chemist developed Toxicologist at French Italian chemist, in Wrote the first German Constantine Fahlberg 1820 “accidental” poisoning. 1800s became addicted and perfected the Marsh test for University of physiologist 1847 discovered American book pharmacologist discovered saccharin to opium in early arsenic. The improved Marsh Edinburgh wrote Treatise on studied the effects nitroglycerin, a dedicated to Friedrich Gaedcke studied and classified while working in the 1800’s and test was used forensically for laboratory of Ira Poisons in 1829; invented of carbon monoxide and powerful explosive poisons in 1869 French pharmacists isolated 1855 Isolated hallucinogenic plants, published Confessions of an the first time in 1840 during the Remsen (right) poison harpoon for whaling curare. Influenced by and vasodilator. Alfred entitled: Microchemistry of quinine from bark of Cinchona cocaine from alcohols and other Opium Eater in 1821. trial of Marie Lafarge. Isolated the stimulant caffeine in 1879. that contained prussic acid. Francoise Magendie. Nobel was his student. Poisons. tree in back of their pharmacy. Erythroxylon coca. psychoactive compounds. from plant extracts in 1895.

Upton Sinclair Pure Food and Chemical Warfare A U.S. Prohibition Geneva Protocol Ginger Jake 1929 Hawk's Nest Gerhard Schrader Elixir Sulfanilamide Albert Hofmann Marijuana Tax Act (1878-1968) Drugs Act - 1906 Reality 1915 1919-1933 1925 Alcoholic tonic produced Incident 1927-1935 (1903-1990) 1937 1938 1937 Published Harvey Washington German Law that made Banned use of illegally during prohibition Hundreds of black German Chemist Food Drug & Lysergic acid Federal criminal 1900-1930s The Jungle Wiley, M.D. (1844- chemist Fritz the production chemical weapons. adulterated with TOCP workers die from accidentally (LSD) synthesized offense to possess, 1930). Law prevents Cosmetic Act in 1905. Haber (1868-1934) and sale of Updated in 1993 produced OPIDN acute silicosis while made nerve agents; sarin, tabun, in the Sandoz produce, or dispense production or trafficking 1938 Chronicled the unsanitary of mislabeled, adulterated developed blistering agents alcoholic beverages as the “Chemical Weapons (Jake Leg), digging tunnel for a soman, and cyclosarin while Laboratory (now hemp. Non-medical 100 die, diethylene conditions in meat packing or poisonous foods, drugs, used in WWI; chlorine and illegal but very profitable. Convention” to include affecting 50,000 hydroelectric project developing insecticides 1938; Novartis). In 1943 Hoffman use prohibited in California (1915) glycol as a vehicle. industry in Chicago. medicines, and liquors. cyanide gases. banning production. adults. for Union Carbide. agents used in WWII. tested LSD on himself. and Texas (1919).

DDT – 1939 2,4-D – 1946 Minimata Japan Poison Control Journal of Tox. & Thalidomide Society of Toxicology Alice Hamilton Rachel Carson Occupational Safety U.S. EPA Recognized as Developed during (1950’s) Centers 1953 App. Pharmacology (1959-1960’s) 1961 (1869-1970) (1907-1964) & Health Act 1970 1970 insecticide by the Swiss WW II at British Minimata Bay First, Chicago 1959 Drug prescribed Founded Pathologist and Scientist lead Act passed on December Established to 1940-1960s scientist Paul Hermann Rothamsted to pregnant women for contaminated 1953, second Adopted by March 4, 1961, first female faculty crusade against the use of 29, 1970 to ensure every consolidate federal research, on Müller, who was awarded Experimental morning sickness induced with mercury by chemical at Duke SOT until 1981 first formal member at Harvard dichlorodiphenyltrichloroethane worker a safe and healthful monitoring, standard-setting the 1948 Nobel Station, by J.H. Quastela industry. Thousands adults birth defects. Medical School. Associated (DDT) a pesticide and University, when SOT meeting held April 15, 1962 workplace. and enforcement activities to and children were poisoned Frances Kelsey worksite chemical hazards persistent organic pollutant. Prize in Physiology and sold commercially in NC in 1954, and third founded Fundamentals of (9 founders, 183 ensure human & environmental from eating fish contaminated of FDA blocked with disease. Studied effects Carson several books including and Medicine. 1946. Used to control opened in Boston 1955. Applied Toxicology. charter members). protection. Banned in 1972. broadleaf plants. with methyl mercury. approval in U.S. of lead & rubber on workers. Silent Spring published 1962.

Mr. Yuk Iraq – Mercury Bangladeshi 1970s First Modern Love Canal Disaster IUTOX 1980 Times Beach 1983 Bhopal Disaster Chernobyl Accident Tokyo Subway Sarin Vioxx (1999-2004) 1971 1971 Arsenic poisoning Toxicology 1978 International Union of Dangerous levels of dioxin Dec. 3, 1984 April 26, 1986 Gas Attack 1995 A nonsteroidal anti-inflammatory, Toxicology Symbol adopted Pink- Tubewells, August 7, 1978 discovered in Times Beach, Accidental release The Chernobyl Members of religious group COX-2 selective inhibitor for 1970-2006 Textbook American Board MO. EPA orders treatment of osteoarthritis, by the Pittsburgh Poison colored drilled to US President 40 metric tons of nuclear power plant Aum 1975 of Toxicology (ABT) the town produced by Merck & Co. Center at The Children’s seed grain coated with a provide clean Jimmy Carter methyl isocyanate accident produced a Shinrikyo Louis J. Casarett declared Love Canal a federal evacuation and from a Union plume of radioactive and voluntarily Hospital in 1971. Used to mercury fungicide was drinking water, are 1979 - First exam Aug. 1980 released sarin & John Doull edited, emergency. 42 million pounds Academy of makes it a Carbide Indian pesticide plant debris over the withdrawn because educate children and parents tragically consumed by contaminated by arsenic gas in 5 places about poisons and to prevent Toxicology: The Basic of over 200 chemicals Toxicological Superfund site. in heart of city resulted in the Ukraine, Eastern in Tokyo subway, killing of risk of heart Iraqis tragically affecting resulting in millions of contaminated Love Canal, killing thousands, and injured Europe, Scandinavia, UK and accidental poisonings. Science of Poisons, in 1975. Sciences (ATS) All residents gone 12 and injuring 6,000. attack & stroke. over 40,000 people. people harmed. disrupting many lives. 1981 by 1985. 100s of thousands. eastern USA. Historical Milestones and Discoveries Which Shaped the Toxicology Sciences Steven G. Gilbert1 and Antoinette Hayes2 1800s The New School. “Thomas de Quincey” [on-line image] Available at http://cepa.newschool.edu/het/profiles/image/quincey.gif (accessed December 2005). 1 2 Institute of Neurotoxicology and Neurological Disorders and Northeastern University Uppingham School, UK. “James Marsh” (Marsh test apparatus, diagram from W.A.Campbell, Chemistry in Britain, 1965, 1, 200-201.). [on-line image] Available at http://www.chm.bris.ac.uk/motm/arsine/arsinev.htm (accessed Knowledge of the toxic and healing properties of plants, animals, and minerals has shaped civilization for millennia. The foundations of December 2005). modern toxicology are built upon the significant milestones and discoveries of serendipity and crude experimentation. Throughout the ages, Smithsonian Institution Libraries. “Robert Chritison” [on-line image] Available at http://www.sil.si.edu/digitalcollections/hst/scientific-identity/thumbnails/TNSIL14-C3-14.jpg (accessed December 2005). toxicological science has provided information that has shaped and guided society. This poster presentation examines the development of the Wikipedia. “Claude Bernard” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/2/23/Claude_Bernard.jpg (accessed December 2005) Copyright expired. discipline of toxicology and its influence on civilization by highlighting significant milestones and discoveries related to toxicology. The Nobel Prize. “Ascanio Sobrero” [on-line image] Available at http://nobelprize.org/nobel/alfred-nobel/biographical/life-work/sobrero.html (accessed December 2005). examples shed light on the beginnings of toxicology, as well as examine lessons learned and re-learned. This project is also an effort to Encyclopedia Dicksonia. “Theo G. Wormley” [on-line image] Available at http://chronicles.dickinson.edu/encyclo/w/ed_wormleyTG.htm (accessed December 2005). Wikipedia. “Joseph Caventou & Pierre Pelletier” Quinine [on-line image] Available at http://en.wikipedia.org/wiki/Image:Chinina.png (accessed December 2005). examine how toxicology and the toxicologist have interacted with other scientific and cultural disciplines, including religion, politics, and the History of Pharmacy. “Joseph Caventou & Pierre Pelletier” [on-line image] Available at http://evans.amedd.army.mil/pharmnew/images/THOM/24.jpg (accessed December 2005). government. Toxicology has evolved to a true scientific discipline with its own dedicated scientists, educational institutes, sub-disciplines, Wikipedia. “Cocaine” (“Friedrich Gaedcke”) [on-line image] Available at http://en.wikipedia.org/wiki/Image:Coca.jpg (accessed January 2006). professional societies, and journals. It now stands as its own entity while traversing such fields as chemistry, physiology, and pharmacology. The Lycaeum “Louis Lewin” 1999 [on-line image] Available at http://nepenthes.lycaeum.org/People/Images/lewin.jpg (accessed December 2005). Wikipedia. “Chloroform” [on-line image] Available at http://upload.wikimedia.org/wikipedia/commons/6/66/Trichl%C3%B3rmet%C3%A1n.jpg (accessed December 2005). We invite you to join us on a path of discovery and to offer your suggestions as to what are the most significant milestones and discoveries in Nobel Prize. “Emil Fischer” [on-line image] Available at http://nobelprize.org/chemistry/laureates/1902/fischer-bio.html (accessed December 2005). toxicology. An interactive version of the poster is available at www.asmalldoseof.org. Wikipedia. “Caffeine” [online image] Available at http://en.wikipedia.org/wiki/Caffeine (accessed December 2005). Wikipedia. “Constantine Fahlberg” (Ira Remsen) 2003 [on-line image] Available at http://en.wikipedia.org/wiki/Image:Untitled01.jpg (accessed December 2005).

1900–1930s Antiquity Wikipedia. “Upton Sinclair” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/c/c6/Sinclair.jpg (accessed December 2005). National Library of Medicine. “Shen Nung” [on-line image] Available at http://www.nlm.nih.gov/hmd/chinese/emperors.html (accessed December 2005) Wikipedia. “The Jungle Cover” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/3/3b/Jungle_cover.jpg (accessed December 2005). Ebers, G. “Papyros Ebers” (Ebers Papyrus), Leipzig, 1875 [on-line image] Available at http://www.nlm.nih.gov/hmd/breath/breath_exhibit/MindBodySpirit/originframe.html (accessed Food and Drug Administration. “Pure Food and Drugs Act” (Harvey Washington Wiley, head of the Division of Chemistry of the U.S. Department of Agriculture, predecessor of the FDA with December 2005) his technical staff) [on-line image] Available at http://www.fda.gov/oc/history/default.htm (accessed December 2005). Wikipedia. “Gula” [on-line image] Available at http://en.wikipedia.org/wiki/Gula (accessed December 2005) ENCARTA. “Chemical Warfare A Reality” (Corbis image 0005c04d) [on-line image] Available at http://encarta.msn.com/media_681500223_761569981_- Wikipedia. “Homer” (2005) (Photograph taken of the bust of Homer in the British Museum, London.) [on-line image] Available at 1_1/Gas_Masks_from_World_War_I.html (accessed December 2005). http://en.wikipedia.org/wiki/Image:Homer_British_Museum.jpg (accessed December 2005) Copyright expired. Wikipedia. “Prohibition” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Prohibition.jpg (accessed December 2005). Wikipedia. “Socrates” [on-line image] Available at http://en.wikipedia.org/wiki/Socrates (accessed December 2005). Wikipedia. “Geneva Protocal” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/6/68/Mustard_gas_burns.jpg (accessed December 2005). University of Washington, School of Public Health and Community Safety. “Hippocrates” (2005) [on-line image] Available at Wikipedia. “Ginger Jake” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/a/a9/TOCP_structure.png (accessed December 2005). http://depts.washington.edu/envhlth/info/newsletter_html/springsummer03.html#2 (accessed December 2005) Bhopal.net. “Hawk’s Nest Incident” [on-line image] Available at http://www.bhopal.net/oldsite/dow-watch/ (accessed December 2005). Fort Carson MEDDAC.“Mithridates” (2005) [on-line image] Available at http://evans.amedd.army.mil/pharmnew/images/THOM/Hist06.htm (accessed December 2005). Wendeburger Heimatkunde Heft 24. “Gerhard Schrader” [on-line image] Available at http://www.verlag-uwe-krebs.de/AbbildungenPict/Dr_Schrader1blue.gif (accessed December 2005). Golnik, Thomas. “L. Cornelius Sulla” (10/05/2001) [on-line image] Available at http://www.thomas-golnik.de (accessed December 2005) FDA. “Elixir Sulfanilamide” [on-line image] Available at http://www.fda.gov/cder/about/history/Graphics/sulfanilamideLrg.jpg (accessed December 2005). Wikipedia. “Cleopatra” [on-line image] Available at http://en.wikipedia.org/wiki/Cleopatra (accessed December 2005) The Vaults of EROWID. “Albert Hofmann” [on-line image] Available at http://www.erowid.org/culture/characters/hofmann_albert/hofmann_albert.shtml (accessed December 2005). The British Library Board. “Dioscorides” [on-line image] Available at http://www.es.flinders.edu.au/%7Emattom/science%2Bsociety/lectures/illustrations/lecture11/dioscorides.html Wikipedia. “Marijuana Tax Act” [on-line image] (credited to the United States Fish and Wildlife Service) Available at http://en.wikipedia.org/wiki/Image:Marijuana.jpg (accessed December (accessed December 2005) 2005). Wikipedia. “Mount Vesucius” [on-line image] Available at http://en.wikipedia.org/wiki/Mount_Vesuvius (accessed December 2005) 1940–1960s Middle Ages Wikipedia. “DDT” [on-line image] Available at http://en.wikipedia.org/wiki/Image:DDT_chemical_structure_highres.png (accessed December 2005). Wikipedia. “Greek Fire” [on-line image] Available at http://en.wikipedia.org/wiki/Greek_fire (accessed December 2005). Nobel Prize. “Paul Muller” [on-line image] (DDT) Available at http://nobelprize.org/medicine/laureates/1948/muller-bio.html (accessed December 2005). Wikipedia. “Ergot Outbreak” [on-line image] Available at http://en.wikipedia.org/wiki/Ergot (accessed December 2005). Wikipedia. “2,4-D” (J.H. Quastela) [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/2/23/ProfQimage.jpg (accessed December 2005). Wikimedia. “Moses Maimonides” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/6/66/Rambam.jpg (accessed December 2005). After Image Gallery. “Minimata Japan” [on-line image] Available at http://www.afterimagegallery.com/smithprints.htm (accessed December 2005). Wikipedia. “Abertus Magnus” [on-line image] Available at http://en.wikipedia.org/wiki/Image:AlbertusMagnus.jpg (accessed December 2005). MIEMSS Pediatric Data Resources. “Poison Control Centers” [on-line image] Available at http://www.miemss.org/EMSCwww/PedData.htm (accessed December 2005). Wikipedia. “Raymundus Lullius” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Ramon_Llull.jpg (accessed December 2005) Copyright expired. Thalidomide Victims Association of Canada (TVAC). “Thalidomide” (Baby) [on-line image] Available at http://www.thalidomide.ca/en/index.html (accessed December 2005). Wikipedia. “Knights Templars” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Templar_fresco_cornwall_england_simon_brighton.jpg (accessed December 2005) Wikipedia. “Thalidomide” (Frances Kelsey) [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/9/93/Kelsey_01.jpg (accessed December 2005). Copyright expired. IUTOX. “International Union of Toxicology” [on-line image] Available at http://www.iutox.org/feedback.asp (accessed December 2005) Copyright 2006. Harvard Medical Library. “Petrus de Abano” [on-line image] Available at http://www.countway.med.harvard.edu/rarebooks/exhibits/fifteeners/fifteeners3.html (accessed December 2005). Elsevier. “Journal of Toxicology and Applied Pharmacology” [on-line image] Available at http://www.elsevier.com/wps/find/journaldescription.cws_home/622951/description#description Wikipedia. “The Black Death” Toggenburg Bible (1411) [on-line image] Available at http://en.wikipedia.org/wiki/Black_death (accessed December 2005). (accessed December 2005) Copyright 2006. Wikipedia. “Venetian Council of Ten” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Most_serene_republic_coat_of_arms.jpg (accessed December 2005). Copyright Society of Toxicology History 1961–1986. “Society of Toxicology” (The Founders of the Society of Toxicology) [on-line image] Available at http://www.asmalldoseof.org/historyoftox/1940- expired. 1960s.htox.php (accessed December 2005) New Mexico State University. “Radiation Symbol” (Zhou Man) [on-line image] Available at http://www.nmsu.edu/%7Esafety/resources/safety_signs.htm (accessed December 2005). Copyright 2006 Society of Toxicology. Wikipedia. “Cesare Borgia” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Cesareborgia.jpg and www.mrsedivy.com/quotes5.html (accessed December 2005). Copyright Society of Toxicology. “Society of Toxicology” (Salus) [on-line image] Available at http://www.toxicology.org/ai/misc/support.asp (accessed December 2005) Copyright 2006 Society of expired. Toxicology. Wikipedia. “Alice Hamilton” Images from the History of Medicine, B014009 [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/4/4a/Alice_hamilton.jpg (accessed December Renaissance 2005). Wikipedia. “Rachel Carson” Fish and Wildlife Service employee photo. © 1940 [on-line image] Available at http://en.wikipedia.org/wiki/Image:Rachel-Carson.jpg (accessed December 2005). Wikipedia. “Leonardo da Vinci” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Leonardo_self.jpg (accessed December 2005). Copyright expired. Wikipedia. “Rachel Carson” (Silent Spring) [on-line image] Available at http://www.rachelcarson.org/ (accessed December 2005). Wikipedia. “PopeClementVII” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Clement7.JPG (accessed December 2005). Copyright expired. Occupational Safety & Health. “Occupational Safety & Health Logo” [on-line image] Available at http://www.osha.gov/ (accessed December 2005). Wikipedia. “Paracelsus” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Paracelsus.jpg (accessed December 2005). Copyright expired. Wikipedia. “U.S. EPA Logo” Fish and Wildlife Service employee photo. c. 1940 [on-line image] Available at http://en.wikipedia.org/wiki/Image:Environmental_Protection_Agency_logo.png Wikipedia. “Georgius Agricola” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Georg_Agricola.jpg (accessed December 2005). Copyright expired. (accessed December 2005). Wikipedia. “Catherine Medici” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/3/3e/Mid_horoscope_catherine_de_medici.jpg (accessed December 2005). Botanical. “William Piso” (image from Medizinal Pflanzen, first published in 1887, by Franz Eugen Köhler) [on-line image] Available at http://www.botanical.com/botanical/mgmh/i/ipecac07.html (accessed December 2005). 1970–2006 Wikipedia. “Shakespeare” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Shakespeare.jpg (accessed December 2005) from the National Portrait Library, London, England. Wikipedia. “Mr. Yuk” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/c/ce/Newyuk.png (accessed December 2005) Copyright ChospPgh. Theodore Gray. “Hieronyma Spara” [on-line image] Available at http://www.theodoregray.com/PeriodicTable/Samples/033.8/s7s.JPG (accessed December 2005). Unesco.org. “Iraq–Mercury” [on-line image] Available at http://www.unesco.org/courier/2001_01/photoshr/10.htm (accessed December 2005) Copyright Lathigra-F.S.P./Gamma, Paris. NNDB. “Catherine Monvoisin (LaVoisin)” Available at http://www.nndb.com/people/875/000094593/. Copyright 2005 Soylent Communications. McGraw Hill Professional Bookstore. “First Modern Toxicology Textbook” [on-line image] Available at http://books.mcgrawhill.com/getbook.php?isbn=0071347216&template= (accessed Wikipedia. “King Louis XIV” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Louis_XIV_of_France.jpg (accessed December 2005). December 2005). University Archives, State University of New York at Buffalo. “Love Canal Disaster” September 5, 1980 [on-line image] Available at 1700s http://ublib.buffalo.edu/libraries/projects/lovecanal/aerial_photos/aerial_1980.html (accessed December 2005) Copyright 2006. Wikipedia. “Devonshire Colic” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/6/6c/Cyder-rebuttal.jpg; http://www.devon.gov.uk/library/locstudy/1769alc.html American Board of Toxicology. “ABT Logo” [on-line image] Available at http://www.abtox.org/ (accessed December 2005) Copyright 2006. (accessed December 2005). Academy of Toxicological Sciences. “ATS Logo” [on-line image] Available at http://www.acadtoxsci.org/ (accessed December 2005) Copyright 2006 Academy of Toxicological Sciences. Wikipedia. “Poppy” [on-line image] Available at http://en.wikipedia.org/wiki/Poppy (accessed December 2005). The Eco Outlet. “Times Beach” [on-line image] Available at http://shop.ecoiq.com/acb/showdetl.cfm?&DID=23&Product_ID=1740&CATID=155 (accessed December 2005). Wikipedia. “Richard Meade” [on-line image] Available at http://en.wikipedia.org/wiki/Richard_Mead (accessed December 2005). Wikipedia. “Bhopal Disaster” December 1984 [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/6/64/Time_Bhopal.jpg (accessed December 2005) Copyright 2006 Time Wikipedia. “Carl Wilhelm Scheele” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Carl_Wilhelm_Scheele_from_Familj-Journalen1874.png (accessed December 2005). Magazine. Surgical Tutor. “Percivall Pott” [on-line image] Available at http://www.surgical-tutor.org.uk/default-home.htm?surgeons/pott.htm (accessed December 2005). Wikipedia. “Chernobyl Accident” [on-line image] Available at http://en.wikipedia.org/wiki/Image:ChernobylPlant.jpg (accessed December 2005). Universitá di Pisa. “Felice Fontana” [on-line image] May 4, 2005 [on-line image] Available at http://biblio.adm.unipi.it:8081/find.jsp?name=fontana.jpg; From Tokyo Press. “Tokyo Subway Sarin Gas Attack” [on-line image] Available at http://www.metro.tokyo.jp/ENGLISH/ADMINI/PRESS/2003/03081203.htm (Extracted from Public information of http://pacs.unica.it/biblio/fig31e (accessed December 2005). Tokyo Metropolitan Police Department) General Anaesthesia.com. “Freidrich Serturner” [on-line image] Available at http://www.general-anaesthesia.com/people/friedrich-serturner.html (accessed December 2005). (accessed December 2005). Marshall University. “Francoise Magendie” [on-line image] Available at http://www.marshall.edu/library/speccoll/virtual_museum/hoffman/magendie.asp (accessed December 2005). Wikipedia. “Vioxx” [on-line image] Available at http://en.wikipedia.org/wiki/Image:Rofecoxib.png (accessed December 2005) Copyright expired. Drugstore Museum. “Fowler’s Solution” [on-line image] Available at http://drugstoremuseum.com/sections/level_info2.php?level_id=145d%22vel=2%20 (accessed December 2005). Msjekyll. “Pierre Ordinaire” (Absinthe Label) [on-line image] Available at http://absinthe.msjekyll.com/ (accessed December 2005). Wikipedia. “Mateu J.B. Orfila” [on-line image] Available at http://upload.wikimedia.org/wikipedia/en/6/67/Mathieu_Joseph_Bonaventure_Orfila.jpg (accessed December 2005) Copyright expired.