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Dec 2016 a Compilation of the Indexed Publications of the Institution Is Provided Herewith

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Dec 2016 a Compilation of the Indexed Publications of the Institution Is Provided Herewith Editor’s Message: Dear Friends, The Annual Research Digest for the term Jan - Dec 2016 a compilation of the Indexed publications of the institution is provided herewith. Though this is mean to include all publications that were generated by our scientists students and faculty during this time period-there are certainly likely to be lacunae. Do browse through the document and let us know if there are more of your publications which need to be added. We would like to thank Dodd Memorial Library, the staff at the research office for compiling the current issue. Dr. Biju George MBBS MD DM Addl. Vice-Principal (Research) Research Digest Contents Basic / Laboratory Sciences - 4 - 44 Clinical Sciences - 45 - 144 Epidemiology - 145 - 171 Miscellaneous including Case reports - 172 - 209 Special request to CMC Faculty Please use the online submission facility on the Dodd Library Website to submit details of all your indexed and non indexed publications. Please also send pdf or word files of your publications to [email protected] so that we can have copies of all publications. Dr. Biju George MBBS MD DM ResearchADDL. VICE - PRINCIPAL (RESEARCH) Digest Research Digest Christian Medical College, Vellore Amirtharaj GJ(1), Natarajan SK(1), Pulimood A(1), Threat J Glob Infect Dis. 2016 Jan-Mar;8(1):41-50. Balasubramanian KA(1), Venkatraman A(2), doi: 10.4103/0974-777X.176149. Ramachandran A(3). Role of Oxygen Free Radicals, Nitric Oxide and Author information: Mitochondria in Mediating CardiacAlterations During (1)Department of Clinical Microbiology, Christian Liver Cirrhosis Induced by Thioacetamide. MedicalCollege,Vellore,TamilNadu,India. Cardiovasc Toxicol. 2016 Apr 30. [Epub ahead of print] Carbapenemase producing Gram-negative pathogen is of great concern for physicianThe challenging Author information: aspects are treatment option and infection control. (1)The Wellcome Trust Research Laboratory, Division Monitoring ofrespective carbapenemase resistance of Gastrointestinal Sciences, Christian Medical College, mechanism is necessary to prevent theoutbreaks. Ida Scudder Road, Vellore, 632004, India. (2)Center Currently, the rapid emergence of oxacillinase (OXA- for Stem Cell Research, Christian Medical College, Ida 48) like isalarming. Increasing frequency of OXA-48 Scudder Road, Vellore, 632004, India. (3)The is seen than the classical carbapenemase(KPC, NDM, Wellcome Trust Research Laboratory, Division of IMP, and VIM) across the world. The bla OXA-48 Gastrointestinal Sciences, Christian Medical College, gene is commonlyidentified in Escherichia coli and Ida Scudder Road, Vellore, 632004, India. Klebsiella pneumoniae. The transferrableplasmid of [email protected]. OXA-48 is associated with rapid spread and inter- speciesdissemination. In general, OXA-48-like Thioacetamide (TAA) administration is widely used enzymes weakly hydrolyzes both carbapenemand for induction of liver cirrhosis in rats, where reactive broad spectrum cephalosporins. Except OXA-163, oxygen radicals (ROS) and nitric oxide (NO) which effectively hydrolyzecephalosporin. This poor participate in development of liver damage. Cardiac hydrolytic profile obscures the detection ofOXA-48- dysfunction is an important complication of liver like. It may go undetected in routine diagnosis and cirrhosis, but the role of ROS or NO in cardiac complicates thetreatment option. Co-production of abnormalities during liver cirrhosis is not well OXA-48-like with CTX-M-15 and understood. This was investigated in animals after othercarbapenemase (NDM, VIM) leads to the TAA-induced liver cirrhosis and temporal changes in emergence of multidrug resistant strains.DOI: oxidative stress, NO and mitochondrial function in the 10.4103/0974-777X.176149 heart evaluated. TAA induced elevation in cardiac NAT levels of nitrate before development of frank liver PMCID: PMC4785756 PMID:27013843 cirrhosis, without gross histological alterations. This BS was accompanied by an early induction of P38 MAP kinase, which is influenced by ROS and plays an Bakthavatchalam YD(1), Pragasam AK, Anandan important signaling role for induction of iNOS. S, Joshi S, Chaudhuri BN, Chitnis DS,Roy I, Tapan D, Increased nitrotyrosine, protein oxidation and lipid Veeraraghavan B. peroxidation in the heart and cardiac mitochondria, Comparative in-vitro activity of ceftaroline against suggestive of oxidative stress, also preceded frank Staphylococcus aureusiso J Infect Dev Ctries. 2016 liver cirrhosis Jan 31;10(1):109-12. doi: 10.3855/jidc.7196ates However, compromised cardiac mitochondrial from India function with a decrease in respiratory control ratio and increased mitochondrial swelling was seen later, when cirrhosis was evident. In conclusion, TAA Author information: induces elevations in ROS and NO in the heart in (1)Christian Medical College, Vellore, India. parallel to early liver damage. This leads to later [email protected] development of functional deficits in cardiac INTL mitochondria after development of liver cirrhosis. PMID:26829546 DOI: 10.1007/s12012-016-9371-1 BS INTL PMID:27131982 Chacko G(1). Epidermal growth factor gene amplification in BS high grade gliomas.Neurol India. 2016 Jan- Feb;64(1):25-6. doi: 10.4103/0028-3886.173672. Bakthavatchalam YD(1), Anandan S(1), Veeraraghavan B(1). Laboratory Detection and Clinical Implication of Oxacillinase-48 likeCarbapenemase: The Hidden Volume I Issue 16 (Jan - Dec 2016) Page 4 Research Digest Christian Medical College, Vellore Author information: (4)Nizam's Institute of MedicalSciences, (1)Department of Pathology, Christian Medical Hyderabad, India. (5)Christian Medical College, College,VelloreTamilNadu,India.DOI: 10.4103/0028- Vellore, India.(6)Department of Medical Genetics, 3886.173672 Kasturba Medical College, Manipal NAT University,Manipal, India.OI: 10.1111/jdv.13587 PMID:26754 INT BS PMID:27168349 BS Chacko MP(1), Augustin A(1), David VG(2), Valson AT(2), Daniel D(1). Deepti Rana, Aleya Tabasuma and Murugan Nonspecific positivity on the Luminex crossmatch Ramalingam. assay for anti-human leukocyteantigen antibodies due Cell-laden alginate/polyacrylamide beads as to antibodies directed against the antibody coated carriers for stem cell delivery: preparation and beads. characterization Indian J Nephrol. 2016 Mar-Apr;26(2):134-7. doi: 10.4103/0971-4065.159305 RSC Adv., 2016, 6, 20475-20484. Stem cell based therapies employ engraftment or Author information: systemic administration methods for the delivery (1)Department of Transfusion Medicine and of stem cells into the target tissues to enhance Immunohematology, Christian MedicalCollege, their regenerative potential. However, majority of Vellore, Tamil Nadu, India. (2)Department of the stem cells were found to migrate away from Nephrology, ChristianMedical College, Vellore, Tamil the target site soon after the transplantation, Nadu, India. which directly hinders their clinical efficacy, in particular while treating cartilage defects. Two cases are described of previously unreported Therefore, the present study was designed to false positivity on the Luminexcrossmatch assay due explore the feasibility and efficacy of an to non HLA specific antibodies directed against the alginate/polyacrylamide (Algi/PAAm) composite beads.In both cases the Luminex crossmatch indicated biomaterial in the form of cell-laden hydrogel the presence of donor specificantibodies to class II beads as a suitable carrier system to be able to HLA antigens, which was not substantiated by the hold the stem cells at the target site and deliver clinicalscenario or other assays. We could them efficiently. Human bone marrow-derived demonstrate the non specificity of theseantibodies mesenchymal stem cells (hBMSCs) have been used through using the same assay in a modified form as a model cell. The beads prepared at an where beads wereunexposed to cell lysate and optimized concentration ratio were characterized therefore did not carry HLA antigens at all. Thesecases to study their physicochemical properties. further serve to emphasize the absolute necessity of Furthermore, cell-encapsulated Algi/PAAm beads correlating positiveresults with the priming history, were evaluated for their biological properties. The and confirming their relevance using result of this study has demonstrated that the otherplatforms.DOI: 10.4103/0971-4065.159305 Algi/PAAm beads with their optimal composition NAT were able to maintain the viability of the PMCID: PMC4795430, PMID:27051139 encapsulated cells during the period of study, BS suggesting the cellular compatibility of the beads. Additionally, the encapsulated cells showed round Chaudhary AK(1), Mohapatra R(2), Nagarajaram morphology within the beads, in contrast to the HA(2), Ranganath P(3,)(4), DalalA(3), Dutta A(5), 2D-cultured spindle-like shape of hBMSCs. Based Danda S(5), Girisha KM(6), Bashyam MD(1). on the experimental data obtained in this study, The novel EDAR p.L397H missense mutation causes cell-laden Algi/PAAm beads may serve as a autosomal dominant hypohidroticectodermal potential carrier system for stem cell delivery. dysplasia. INT J Eur Acad Dermatol Venereol. 2017 Jan;31(1):e17- e20. doi: 10.1111/jdv.13587. Epub 2016 May 11. Hareendran S, Ramakrishna B, Jayandharan GR. Synergistic inhibition of PARP-1 and NF-?B Author information: signaling downregulates immune response against (1)Laboratory of Molecular Oncology, Hyderabad, recombinant AAV2 vectors during hepatic gene India. (2)Laboratory ofComputational biology, therapy. Hyderabad, India. (3)Diagnostics Division,
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