molecules Review The Genus Cladosporium: A Rich Source of Diverse and Bioactive Natural Compounds Maria Michela Salvatore 1 , Anna Andolfi 1,2,* and Rosario Nicoletti 3,4 1 Department of Chemical Sciences, University of Naples ‘Federico II’, 80126 Naples, Italy;
[email protected] 2 BAT Center—Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology, University of Naples ‘Federico II’, Portici, 80055 Naples, Italy 3 Council for Agricultural Research and Economics, Research Centre for Olive, Fruit and Citrus Crops, 81100 Caserta, Italy;
[email protected] 4 Department of Agricultural Sciences, University of Naples ‘Federico II’, 80055 Portici, Italy * Correspondence: andolfi@unina.it; Tel.: +39-081-2539179 Abstract: Fungi are renowned as one of the most fruitful sources of chemodiversity and for their ubiquitous occurrence. Among the many taxonomic groupings considered for the implications deriving from their biosynthetic aptitudes, the genus Cladosporium stands out as one of the most common in indoor environments. A better understanding of the impact of these fungi on human health and activities is clearly based on the improvement of our knowledge of the structural aspects and biological properties of their secondary metabolites, which are reviewed in the present paper. Keywords: natural products; bioactive secondary metabolites; fungal species; fungal extrolites Citation: Salvatore, M.M.; Andolfi, A.; Nicoletti, R. The Genus 1. Introduction Cladosporium: A Rich Source of Diverse and Bioactive Natural Results of recent research in the mycological field have further disclosed the pervasive Compounds. Molecules 2021, 26, 3959. diffusion of fungi in the genus Cladosporium (Dothideomycetes, Cladosporiaceae). Basi- https://doi.org/10.3390/ cally saprophytic, these Ascomycetes are spread in every kind of terrestrial and marine molecules26133959 environment, where they establish various symbiotic relationships with plants and ani- mals [1]; moreover, they are among the most frequent fungi detected in indoor spaces [2,3].