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Effective Ethoxyquin Replacement Effective Ethoxyquin Replacement in Poultry Fat for Fish Feed What are Antioxidants? Antioxidants are added to fats and oils to protect them from rancidity. Fat becomes rancid when exposed to air, heat and bacteria. Fat breaks down in two steps. Hydrolysis yields fatty acids that may actually improve the flavor up to a point (no more than 10%). Oxidation of unsaturated fatty acids yields ketones and free fatty acids that are usually unpalatable and potentially injurious. It takes as little as 0.05% of the fat to react with oxygen to produce rancidity and produce oxidative fragments, some of which are volatile and are perceived as the off-flavours of rancidity reducing the shelf life. Oxygen Unsaturated fatty acid of Triglyceride Free radicals Oxidation of pigments, flavours Hydroperoxides and vitamins Breakdown products Insolubilization (including rancid off-flavour Polymerization of proteins compounds); ketones, (dark color and aldehydes, alcohols, possible toxicity) hydrocarbons, acids, epoxides Why is Ethoxyquin used? Ethoxyquin is a quinoline-based antioxidant used as a food preservative in certain countries. It is commonly used as a preservative in pet foods, fish oils and fish feed to prevent the rancidification of fats. Ethoxyquin is also commonly used in spices to prevent color loss due to oxidation of the natural carotenoid pigments. Why Replace Ethoxyquin • There has been some speculation that ethoxyquin in pet foods might be responsible for multiple health problem and although to date, the U.S. Food and Drug Administration (FDA) has only found a verifiable connection between ethoxyquin and buildup of protoporphyrin IX in the liver, as well as elevations in liver-related enzymes in some animals which have not been linked to any known health consequences. Version 1.00 - March 2016 Dadex is a trade-mark of Caldic BV, all rights reserved - www.caldic.com 1/2 Effective Ethoxyquin Replacement • The levels of Ethoxyquin inclusion in fish feed have been reduced dramatically over the past years. There is a growing concern over the use of Ethoxyquin in the food chain as it has been found in human tissue and breast milk. • There is a rapid movement towards alternatives being led by IFFO (The Marine Ingredients Organization) and consumer groups. Maintaining Product Integrity without the use of Ethoxyquin Excellent performance can be found with human grade synthetic and natural antioxidants in poultry fat such as Dadex® Defend, Dadex® DV-50C and Dadex® TORO Oxidative Stability Performance of Dadex Antioxidants Compared to Ethoxyquin in Poultry Fat 80 70 60 50 40 30 20 10 0 Poultry Fat Poultry Fat + Poultry Fat + Poultry Fat + Poultry Fat + Poultry Fat + Poultry Fat + Control Dadex Defend Dadex DV50C Ethoxyquin Ethoxyquin Dadex TORO Dadex TORO 1x ppm 2x ppm 1y ppm 2y ppm For more information, please contact Caldic B.V. [email protected] www.dadex.ca Follow our latest updates on LinkedIn Version 1.00 - March 2016 Dadex is a trade-mark of Caldic BV, all rights reserved - www.caldic.com 2/2 .

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Draft Screening Assessment
Screening Asse ssment for the Challenge Phenol, (1,1-dimethylethyl)-4-methoxy- (Butylated hydroxyanisole) Chemical Abstracts Service Registry Number 25013-16-5 Environment Canada Health Canada July 2010 Screening Assessment CAS RN 25013-16-5 Synopsis The Ministers of the Environment and of Health have conducted a screening assessment of phenol, (1,1-dimethylethyl)-4-methoxy- (also known as butylated hydroxyanisole or BHA), Chemical Abstracts Service Registry Number 25013-16-5. The substance BHA was identified in the categorization of the Domestic Substances List as a high priority for action under the Challenge, as it was determined to present intermediate potential for exposure of individuals in Canada and was considered to present a high hazard to human health, based upon classification by other agencies on the basis of carcinogenicity. The substance did not meet the ecological categorization criteria for persistence, bioaccumulation or inherent toxicity to aquatic organisms. Therefore, this assessment focuses principally upon information relevant to the evaluation of risks to human health. According to information reported in response to a notice published under section 71 of the Canadian Environmental Protection Act, 1999 (CEPA 1999), no BHA was manufactured in Canada in 2006 at quantities equal to or greater than the reporting threshold of 100 kg. However, between 100 and 1000 kg of BHA was imported into Canada, while between 1000 and 10 000 kg of BHA was used in Canada alone, in a product, in a mixture or in a manufactured item. BHA is permitted for use in Canada as an antioxidant in food. In fats and fat-containing foods, BHA delays the deterioration of flavours and odours and substantially increases the shelf life.
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No. 902, Neohesperidin Dihydrochalcone
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Review Article Ethoxyquin: an Antioxidant Used in Animal Feed
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(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date ;n 10 March 2011 (10.03.2011) 2011/028128 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C09K 15/34 (2006.01) A23L 1/212 (2006.01) kind of national protection available): AE, AG, AL, AM, A23D 9/06 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/NO20 10/000323 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 1 September 2010 (01 .09.2010) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (25) Filing Language: Norwegian SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (26) Publication Langi English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 20092923 1 September 2009 (01 .09.2009) NO kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, (71) Applicant (for all designated States except US): ASK M ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, FRUKT- OG B^ERPRESSERI AS [NO/NO]; Osloveien TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 93, N-1815 Askim (NO).
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