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IN CANNABIS ADVANCED CANNABIS HPLC Pesticide METHOD Testing Development for Baseline Resolution of Seventeen Cannabinoids MAY/JUN 2019 I www.terpenesandtesting.com TERPENES HORTICULTURE CHEMISTRY & ANALYTICS Increasing RETURN ON Getting to INVESTMENT for Pesticide THE ROOT OF Analysis IN CANNABIS ADVANCED CANNABIS HPLC Pesticide METHOD Testing Development for Baseline Resolution of Seventeen Cannabinoids UNTANGLING TERPENES Defining a Cultivar's Fragrant Ensemble Using 2D Chromatography Mycotoxins TO CARRY THE TORCH IN CANNABIS Welcoming the Next-Generation Lessons from Other Stored and Packaged Goods of Cannabis Scientists Developing Better Products through Natural Chemistry Penta Manufacturing Company is Family Owned and Operated for Over 40 Years. Here is a partial listing of our Family of Natural Terpene ingredients utilized in flavor & fragrance formulations. For detailed paperwork on all of our items consult our web site at www.pentamfg.com ■ BAY OIL TERPENES ■ LEMON TERPENES EX-5 FOLD ■ BERGAMOT TERPENES ■ LIME OIL TERPENES ■ CEDARWOOD TERPENES ■ LITSEA CUBEBA OIL TERPENES ■ CITRAL TERPENES ■ ORANGE TERPENES ■ CITRONELLA TERPENES ■ PEPPERMINT TERPENES ■ CLOVE TERPENES ■ PETITGRAIN OIL TERPENES ■ CORNMINT OIL TERPENES ■ RHODINYL TERPENES ■ EUCALYPTUS TERPENES ■ ROSEMARY TERPENES ■ GRAPEFRUIT OIL TERPENES ■ SPEARMINT OIL TERPENES ■ GRAPEFRUIT OIL TERPENES 5 FOLD ■ THIOTERPENES ■ LEMONGRASS OIL TERPENES ■ VETIVER TERPENES ■ LEMON TERPENES DISTILLED For a complete list of all our natural, natural identical and synthetic ingredients visit us at www.pentamfg.com Penta Manufacturing Company A Division of Penta International Corporation 50 Okner Parkway, Livingston, New Jersey 07039-1604 Phone: (973) 740-2300 Fax: (973) 740-1839 E-Mail: [email protected] Web: www.pentamfg.com PF1904_penta_balloon.indd 1 3/4/19 1:31 PM Letter from April 15th, 2019 the Editor This issue serves as a prelude to our upcoming conference, legitimacy within the industry, and increased levels of CONCENTRATION 2019. We wanted to divide and conquer consumer mistrust. In short, a lose-lose situation for all Publisher PREVENT each pathway that we explore in our publications with our those involved. MACE Media Group conferences this year, and as such, Concentration 2019 Therefore, it’s integral for laboratories and cannabis CEO will focus on the extraction of cannabis and hemp. Later in Celeste Miranda early August, CannaFarmCon 2019 will delve into cannabis farmers and product manufacturers to arm themselves with END-TO-END defensible data. To that end, instrument manufacturers are Editor-in-Chief farming and agronomy. The quantitative analysis of analytes Jason S. Lupoi, Ph.D. and contaminants in botanical plants and products is consistently venturing out onto the frontier, designing more ubiquitous, therefore, analytical chemistry will be integral to sensitive and specific instrumentation, all the while aiming Authors: CONTAMINATION each symposium we do. for lower costs. They are also increasingly developing Cindy S. Orser PhD turnkey solutions such that those with less experience with Edward Franklin, PhD. The analytical chemist knows that, blessing or curse, in any analytical instrumentation can still utilize the tool in their Melissa Wilcox direct he or she looks, there is data to be studied. It’s all quest for wisdom. Kimberly Ross, PhD. data, isn’t it? From the sampling of whatever, measurement Sean Myers by whichever device, to the processing of the results. You may find this issue to be heavy on mass spectrometry, Stephen Goldman, M.Sc. These words could describe a sensory analysis of a smell, and for good reason. While chromatographical separations Kevin Koby perhaps the deceivingly funky fragrance of Vic Secret hops; have been well-discussed, increasing demands for ensuring Marco Troiani or the analysis of cannabis inflorescences for pesticide and product safety require more sensitive detectors. Consider Savino Sguera mycotoxin contamination. Sample, measure, process…these pesticide analysis. Given the glut of analytes that need to Toby Astill Alex Hodgson, M.S. three terms are at the core of analytical decision making. be quantified when declaring a product pesticide-free (or at least below permissible concentrations), instrumentation Chris Hernandez, M.S. In some cases, left over extraction solvents remain in the product. These impurities can be toxic, And whether you’re a cannabis farmer, processor, scientist, Milan Patel medical doctor, regulator, caregiver, consumer, or even that not only resolves the assortment of chemicals, but also pushes detection limit boundaries can better ensure Carl Yamashiro, PhD. which is why residual solvent analysis is a critical element of cannabis testing. The Clarus® skeptic, there are analytical decisions to be made. Cannabis Bob Clifford, PhD. SQ 8 GC/MS is unsurpassed in both sensitivity and stability. Coupled with the TurboMatrix™ success. and/or its subsidiaries. Inc. are the property of PerkinElmer, or registered trademarks All trademarks Inc. PerkinElmer, © 2018 analytics define the legitimacy of the industry. They validate it. Heather Reece There’s no reason or excuse to be without data. Or to Jeff Dahl, PhD. headspace sampler and engineered to deliver unparalleled precision, accuracy, and productivity, Which brings us to this issue. Given that CONCENTRATION ® gamble on product quality. While meticulous labs act Vikki Johnson the Clarus GC/MS system is the clear choice for laboratories serving the cannabis market. Our Clarus GC/MS with TurboMatrix™ Headspace 2019 will be divvied up between extraction and analytical Dylan Wilks, PhD. science and technology, we found it fitting to mirror as industry sentinels, protecting the populace from preinstalled method for GC/MS-HS technology leverages the identical instrumentation required those themes herein. One of the most prevalent topics contaminated products, there’s accessible knowledge to Designer for terpene analysis, allowing the streamlined lab to run both tests simultaneously. in the media regards the failure of cannabis samples for excavate, for any cannabis business to embrace. Marko Nedeljkovic containing contamination beyond permissible levels. Until next time, Advertising: Some of these samples made it into dispensaries, forging Mark Nockels For more information on visit: www.perkinelmer.com/cannabis a scenario rife with finger-pointing, fines, decreased Cheers. Casey Walsh All your processing needs, inside and out. Decarboxylation • Distillation • Extraction • Mixing • Recrystallization • Solvent Recovery Need AD 800-223-4524 aceglass.com TT-halfpagebleed-Q2.indd 1 4/16/2019 8:07:11 AM To Carry the Torch: 08 The Next-Generation of Cannabis Scientists Contents Everything is 12 Turning Up Terpenes! CANNABIS CHEMISTRY SUBDIVISION IS PROUD TO PRESENT THE HPLC Method Development for 16 Baseline Resolution of Seventeen Cannabinoids 20 Mycotoxins in Cannabis - Lessons from Other Stored and Packaged Goods ElSohLy Award The Fundamentals of LC/MS 24 “I am honored for the ACS Cannabis Chemistry Subdivision to name the EISohly Award after me. I am excited to meet new talented scientists who are working on cannabis chemistry and are deserving of this award.” Dr. Mahmoud ElSohly 30 Untangling Terpenes The first ever award in cannabis chemistry is given to scientists so that they can share their work at the American Chemical Society’s National Meeting Tips and Challenges for Defensible Analysis each year. 32 of Pesticides in Cannabis Products “Winning this award is an honor. I am pleased, as a 2018 scholarship winner, to help select the 2019 winners and to help shape the future of the Bryant Jones Dr. Monica Vialpando Getting to the Root of EISohly Award. This is just what the cannabis industry needed and it’s 38 Advanced Cannabis Pesticide Testing great to see this coming out of the ACS. The Cannabis Chemistry Subdivision has been so prolific as a subdivision, I look forward to seeing how much they can accomplish as a full ACS division.” Not the UV/Vis You Grew Up with: Terpene Isomer Analysis Dr. Jahan Marcu 42 with Gas Chromatography – Vacuum Ultraviolet Spectroscopy Michael Coffin Stephen Goldman Microbes: Why You Don’t Want Them in Cannabis 46 and What’s the Best Way to Test for Them Dr. Melissa Lewis Dr. Jahan Marcu Dr. John de la Para Dr. Mark Scialdone Dr. Linda Klumpers Dr. Michael Schafroth Andrew Pham Increasing Return on Investment 52 for Pesticide Analysis in Cannabis To apply please send your abstract and resume to [email protected] by July 1. In-House Analytical Testing: 56 Spending Money to Save Money www.cannachem.org Follow us at @canndchas SPONSORED BY HEIDOLPH NORTH AMERICA 8 TERPENES & TESTING TERPENES & TESTING 9 To Carry the Torch: The Next-Generation of Cannabis Scientists By Jason S. Lupoi, PhD. Have you ever pondered the thought of nearly 16,000 chemists has bequeathed a generous glut of medicinal molecules for descending upon an odd land where kids and adults alike researchers to identify, quantify, and understand, as modern frolic with mice, dogs, and ducks? I lived it in early April Earthlings resuscitate ancestral knowledge, this time, however, 2019. And while the complete scene was rather daunting, a bolstering anecdote with scientific fact. Mahmoud ElSohly, specific happening beckoned like a revival. The occasion was Ph.D. has contributed a decent chunk of the available scientific the American Chemical Society (ACS) National Meeting. The literature on cannabis chemistry, and so, it was inspiring to city was none other than Orlando, Florida. And while hordes see ElSohly pass the proverbial torch to the awardees, whose flocked to vacate
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