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2021 Active Cruise Bike South Cruise SPLIT - SPLIT Active Cruise Bike South ¸ Route SPLIT – BRAČ – HVAR – PELJEŠAC – MLJET – KORČULA – ŠOLTA – SPLIT This guided cycling tour in Dalmatia starts and ends in Split exploring amazing coastlines, medieval towns, old villages and picturesque bays. Highlights include great beaches, vineyards, pine woods, cycling across the historic islands and exploring Mljet National Park. Croatia is a land of stunning islands, rich history, Mediterranean vegetation and a mild climate. Without a doubt, the best way to explore it is by bike. ITINERARY: Day 1 SPLIT – SUPETAR – PUČIŠĆA (L) Day 5 KORČULA – VELA LUKA (B, D) Bike Course: Supetar – Pučišća Bike Course: Korčula – Pupnat – Smokvica – Prižba – Blato – Vela Luka Length: 25 km | Total ascend: 380 m | Highest point: 90 m Length: 55 km | Total ascend: 750 m | Highest point: 340 m Surface: 100% paved road | Difficulty level: 2/5 Surface: 100% paved road | Difficulty level: 4/5 Arrival in Split and check-in from 11:00. Departure at 13:00 followed by lunch on board on a journey to the After breakfast, you start with the longest route of the week in which you will cycle the whole island island of Brač. Upon arrival in Supetar, you will cycle the coastal road to the northern part of the island of Brač. of Korčula. Ascend to Žrnovo village and then to the oldest settlement on the island - Pupnat, where You are passing the fishing villages Splitska and Postira and arrive in one of the most beautiful small settlements is the highest point of the route. Descend to the south side of Korčula and road ride between one in Europe - Pučišća. Free afternoon for sightseeing this charming place, well known for its long stonemason of the most beautiful bay on the island and the steep cliffs above it. You continue the ride through tradition. Overnight in Pučišća. numerous olive groves and vineyards, one of the most famous grapes variety Pošip. Short break in the charming place Smokvica on half the way. Descend to the sea and refreshment in one of the Day 2 PUČIŠĆA – POKRIVENIK / JELSA – SUĆURAJ – LOVIŠTA (B, L, CD) numerous pebble hidden beaches. Ascend towards the viewpoint above town Blato and finally descend towards our goal - Vela Luka. Dinner on board and overnight in Vela Luka. Bike Course: Pokrivenik – Sućuraj Length: 32 km | Total ascend: 450 m | Highest point: 350 m Day 6 VELA LUKA – HVAR – STARI GRAD (B, L) Surface: 100% paved road | Difficulty level: 3/5 Bike Course 1: Hvar – Stari Grad Breakfast and morning sail towards the longest Croatian island - Hvar with the view on Biokovo mountain. Out Length: 23 km | Total ascend: 450 m | Highest point: 410 m starting point is a small picturesque bay Pokrivenik. Starting with ascending to the highest point of the route Surface: 100% paved road | Difficulty level: 3/5 and descend to the eastern point of Hvar island - Sućuraj, where the ship is waiting. After lunch on board, sail towards the second biggest Croatian peninsula Pelješac and a charming settlement Lovišta. Captain's dinner Bike Course 2: Stari Grad – Jelsa – Vrboska – Stari Grad onboard (included on Premium category). Overnight in Lovišta. Length: 22 km | Total ascend: 110 m | Highest point: 85 m Surface: 85% paved road – 15% macadam | Difficulty level: 1/5 Day 3 LOVIŠTA / KUČIŠTA – TRSTENIK (B, D) Early morning sail from Vela Luka to the town of Hvar, breakfast. Short sightseeing of Hvar, a fairy tale city with its architecture, beautiful nature and mild climate. Cycle from Hvar to the other side of Bike Course: Lovišta / Kučišta – Trstenik the island - Stari Grad. You pass through numerous lavender plants and enjoy the view towards the Length: 45 km / 31 km | Total ascend: 800 m / 580 m | Highest point: 411 m neighbouring islands and mainland. Lunch on board in Stari Grad. Easy afternoon ride up to two Surface: 100% paved road | Difficulty level: 4/5 Hvar's pearls - Jelsa and Vrboska and through Stari Grad Plain where the ancient Greek land division The third-day ride you can call the wine-panoramic route. After breakfast, you start riding towards Orebić, has been preserved to these days like the system of road and plots. Overnight in Stari Grad. the city of seafarers and captains. First few kilometres of ascending and then descending with the unique viewpoints on Korčula archipelago. After Orebić, ascend to the area where the most famous varieties of Day 7 STARI GRAD – STOMORSKA – SPLIT (B, L) Croatian wine succeed. You cross the tunnel Dingač to the south side of Pelješac and continue riding through vineyards to Trstenik. Overnight in Trstenik. Bike Course: Stomorska – Maslinica Length: 36 km | Total ascend: 450 m | Highest point: 135 m Day 4 TRSTENIK – MLJET – KORČULA (B, L) Surface: 100% paved road | Difficulty level: 2/5 The last day you start with cruise from Stari Grad to the island of Šolta. After breakfast, you start cycling Bike Course: National Park Mljet from Stomorska to the highest point of the island - Gornje Selo, enjoying the views on both sides of the Length: 18 km | Total ascend: 120 m | Highest point: 45 m island and the scents of Medditerranean plants. Continue to Maslinica on the west part of the island. Surface: 80% paved road, 20% macadam | Difficulty level: 1/5 Short break and return to Stomorska. Lunch on board and sail to Split. Free afternoon for sightseeing Cruise during breakfast from Trstenik to Mljet island, the lush green island also known as Honey-island. the Diocletian's city. Overnight in Split. Mljet National park (entrance fee to be paid on the spot approx. 17 EUR per person) is a beautiful area of unique charm, featuring two connected saltwater lakes, a lush flora, a unique appearance of indented Day 8 SPLIT (B) coastline, cliffs and numerous islets as well as always green plants of the surrounding hills. You cycle around the saltwater-lake, inside which there is another island with the Benedictine monastery from the 12th An early breakfast before your final goodbyes to new friends and the crew. century. Refreshment in saltwater lakes and return to lunch on board. Sail to Korčula. Free afternoon for exploring the town of Marco Polo. Overnight in Korčula. Legend: B – breakfast, L – lunch, D – dinner, CD – Captain`s dinner Active Cruise Bike South Active Cruise Bike South BIKE RENTAL INCLUDES BIKES EQUIPPED WITH BOTTLE HOLDER, BAG CARRIER, SMALL BAG (14x8x8 cm) & HELMET, EXAMPLE MODELS OF RENTED BIKES: HYBRID BIKE – SPECIFICATION E-BIKE - SPECIFICATION FRAME 700 Alloy WHEEL SIZE 20“ COLOR Matt black PEDALASSIST Up to 25km/h FORK Suntour matt black nex CHAINWHEEL Shimano T4010E866CL3/48T DISPLAY Panasonic Side Lcd OCTALNIK 175 CG MOTOR Panasonic 36v B.B PARTS Shimano BB-ES300B*126 ASSISTANCE LEVELS 4 Assistance levels PEDAL Alloy SP-823 CHAIN Z 9000 GEARS Shimano Nexus 8 Speed Hub Gears REAR DERAILLEUR Shimano DEOREKRD591SGSL BREAKS Magura Hs22 Hydraulic End V – Brake FRONT DERAILLEUR Shimano ALIVIO 4000TSM6 BATTERY 540wh/15ah/36v SHIFTING LEVERS Shimano ALIVIO SLM 4000 FREEWHEEL Shimano CS HG 20091134 CHARGER 36v Panasonic Sharger RIMS X ALT X3 double wall FORK Sr Suntour Nex Suspension Fork 63mm TIRES CST 40-622 SALVO HIGH PROTECTION 5 mm TYRES Svhwalbe Maraton Plus BRAKE V Brake Shimano ABRT 4000 FC14SL ANTI-THEFT PREDECTIONANTI Abus Frame Lock CARRIER TANGSHAN HLJY-F4-28 BLACK Weekly rent: $120- Weekly rent: $180 SWIMMING BREAKS: In good weather and depending on timings we will have regular swim stops while the vessel anchors in secluded bays or after the cycling before departure to the next island. CYCLING ROUTE: The length of the daily cycling routes is estimated and depends on local information and various detours or short cuts that can be done en route. Sailing and cycling routes may be changed on the spot due to weather conditions and capacity of the respective cyclists on board. Departure is during morning hours, mostly after breakfast. BICYCLES: bike rental possible on request; Katarina Line is not responsible for any damage which may occur to personal bicycles during bike tours and transportation from land to the vessel and vice versa. Repair kit for personal bikes obligatory. FOOD: Continental breakfast and either lunch or dinner. During our cycling routes, we recommend stops at local restaurants where you can sample the local specialities. These meals are not included in the price of the trip and are paid by the customers. There is a possibility to book a captain's dinner, which is paid directly on the spot and is offered by the captain and your tour guide. Active Cruise Bike South RATES: SATURDAY check in from 11:00 h from Split harbour; Departure at 13:00 h; PRICE PER PERSON IN EUR IN DBL/TWN CABINS 7 NIGHTS / 8 DAYS Saturday departure Aug 28; - Bike cruise with professional bike guide. Biking Sep 04, 11*; PREMIUM VESSELS recommended equipment biking shoes, backpack, TRADITIONAL ENSUITE extra clothes, rain/sun protection. Repair kit for steel hulled vessels with modern traditional look VESSELS personal bikes obligatory. * PREMIUM offer accommodation in air-conditioned, - Participant agrees to abide to the decisions and $1195 spacious en-suite cabins with double or twin Upper / Main deck instructions given by the guide who reserves the right beds, hair dryer and safety deposit box. Ships Wooden ships, cabins with private * PREMIUM are from 29 to 35m in length with cabins 8 to shower/toilet, mostly bunk beds, air- in changing the itinerary according to weather $1095 conditions. Lower deck 14m2 in size. Included services: Buffet breakfasts, conditioned salon and cabins. Included three course lunches or dinner, Captain’s dinner, services: Continental breakfasts, three course TRADITIONAL ENSUITE daily cabin service, mid-week fresh set of towels and lunches or dinner, bike guide, complimentary - If taking part in biking activities, each individual is $950 bed linen, luggage handling, olive oil and wine water, free WIFI.
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  • Mendelian Diseases and Conditions in Croatian Island Populations: Historic Records and New Insights

    Mendelian Diseases and Conditions in Croatian Island Populations: Historic Records and New Insights

    View metadata, citation and similar papers at core.ac.uk brought to you by CORE Review Mendelian Diseases and Conditions in Croatian Island Populations: Historic Records and New Insights Vanja Saftić1, Diana Rudan2, Lina Zgaga3 1Department of Pediatrics, Osijek Among Croatian islands, there are several which are known for University School of Medicine, Croatia unusual autochthonous diseases and specific medical conditions 2Department of Internal Medicine, that result from the reproductive isolation and specific popula- Holy Ghost General Hospital, Zagreb, Croatia tion genetic structure. These populations are characterized by 3Department of Medical Statistics, high degree of genetic isolation, consanguinity, and inbreeding. Epidemiology, and Medical The reported diseases include Mal de Meleda on Mljet island, Informatics, Andrija Štampar School hereditary dwarfism on Krk island, familial learning disability of Public Health, Zagreb University on Susak island, familial ovarian cancer on Lastovo island, and School of Medicine, Croatia several other rare diseases and conditions inherited in Mende- lian fashion. We present a historical perspective on how these conditions were first described, interpreted, and assessed. We reviewed the information obtained through genetic research in the past several years, when the genetic etiology of some of these > Correspondence to: conditions was explained. The disease gene causing Mal de Me- Diana Rudan leda was first localized at 8q chromosome, and mutations in the Department of Internal ARS (component B) gene encoding SLURP-1 (secreted mam- Medicine General Hospital “Holy malian Ly-6/uPAR-related protein 1) protein were identified Ghost” subsequently. The genetic etiology of dwarfism on the island of Ulica Sveti Duh 64 Krk is explained by a mutation in the PROP1 gene, responsible 10000 Zagreb, Croatia for the short stature.