OCT 1951
SI SPECULUM PLACET, INSPICE SPECULUM THE JOURNAL OF THE Melbourne Medical Student's Society
"Speculum" is published for private circulation among members of the M.S.S. Copies are not supplied to non-members of the Society.
EDITORS M. D. GROUNDS K. A. GRABAU G. McKENZIE
Business Manager E. SINCLAIR
CONTENTS
Pad EDITORIAL 7 PROFESSOR MacCALLUM 8 PROFESSOR E. J. KING 9
PROFESSOR S. L. TOWNSEND 10
Dr. J. A. LARWILL 10
LYSENKO — RIGHT OR WRONG . W. SCHNUR AND C. PRINGLE 12
NEW DEAL FOR JUNIOR R.M.O.'s P. W. GRAHAM 25
PANDEMIC PROF. S. D. RUBBO 30
A CHRISTIAN MEDICAL SCHOOL IN INDIA PROF. E. W. GAULT 33
TWO NEW RELIGIONS 38
MEDICAL SERVICE IN NEW GUINEA 40
CHILD WELFARE IN NEW GUINEA—Some Comments C. W. BAIRD, B.Sc. 41
THE WOMEN'S HOSPITAL 43
PSYCHOLOGY AND SICKNESS F. E. EMERY, M.A. 47
CHINESE SPIRITUALIST MEDICINE TUNG SLEW YOON 51
RESEARCH NOTES 53
BOOK REVIEWS 57
M.S.S. NOTES 59
YEAR NOTES 60
SPORTS NOTES
SPICULA 7 1 SPECULUM 7
EDITORIAL
Speculum is an unusual magazine. There The present editors do not want to write are few other medical magazines which learned articles,* and the contributions to exclude articles on the anabolic effects of other magazines show that very few testosterone on the premature baby. There undergraduates do. are few whose back pages are so popular. Others criticise the political nature of our We have heard criticisms of both these articles. We questioned a group of friends characteristcs of the magazine. Criticism on this matter, and they were unanimous of Spicula we refer to 1950's M.U.M., which in saying that Politics should be out. But neatly summarises the Spicula Controvery none of them classed one article in the past of 1949, and to the Speculum of November, three issues as political. They considered 1 949, where the matter is ably debated. that "political" articles relating to the struc- Criticism of the nature of our articles is ture of medical practice should be included, less easy to answer. Previous editorials have and we could not agree more. Yet we have justified Speculum's policy, but as long as been told that if we want it non-academic we Criticisms continue the editors must answer should nevertheless exclude all political them. articles. We admit that in politics the Some of our critics call for a more magazine has shown bias, but if no stalwart academic magazine. The more academic conservative will produce an article in student magazines with which we exchange defence of the status quo while radicals have, and must have, advisory councils of attack it, we must continue to show bias. graduates. (Montreal, for instance, has a Gentlemen wishing to demonstrate the Council of 16 graduates, the least of whom benevolence or wickedness of Generalissimo is a B.A., M.D.) An academic Speculum Stalin may go elsewhere, but those with would serve little purpose. It is not the views worth reading on the politics of function of the Medical Students' Society to medicine will always be found space. teach itself. The acquisition of medical We welcome criticism, but we will con- knowledge is a matter between the faculty tinue to publish a magazine which, while and individual students, not the society. medical above all, is readable, political, and Resides, any contribution Speculum could unsuitable for mixed company—designed make to our knowledge would be insignifi- for the members of the society, neither pruned for prudes nor written for cant alongside the faculty's contribution. exhibitioners. Speculum would merely provide some of us with practice at writing academic articles. * Nor could they. SPECULUM
PRESENTATION: Professor MacCallum
At the annual general meeting of the for him. In consequence, we have procured M.S.S. in first term the society presented an instrument which we hope will appeal the retiring professor of Pathology, Peter to his tastes, scientific and aesthetic. MacCallum, M.C., MA., N.z., M.Sc., N.z. It is my privilege, Sir, to present to you & MELB., M.B., Ch.B., D.P.H., EDIN., this watch on behalf of the Medical Students F.R.S.E., with a gold evening watch. In of the Melbourne University. You will making the presentation the secretary (Mr. find it engraved: G. Crock) gave the following address: Professor Peter MacCallum. From the Medical Students' Society, Mr. Chairman, Professors, Ladies and Melbourne. 1951 Gentlemen— This is our token of esteem for you per- Today, we have come to one of the sonally and for your able work as a medical milestones in the history of this Medical educator in the University of Melbourne. School and of this Society. Today, Professor Peter MacCallum formally retires as Presi- The professor's appreciation of that great dent of this Society — as he has recently concept, Time, his use of which has made retired from the Chair of Pathology. him legendary among students, has guided I have not come as an enconiast to the executive in its choice of a presentation embarrass our president with well chosen In thanking the society, Professor phrases of praise — but I do feel that this MacCallum said that the presentation had occasion demands from me a brief outline taken him by surprise. He thanked the of the Professor's career. secretary for his remarks, and dealt with his Peter MacCallum graduated from the own history. University of New Zealand in 1908 as M.Sc., Having been in the Melbourne Medical M.A., and in 1909 he proceeded to Edin- School for 26 years, he identified himself burgh, having been Canterbury College with Melbourne before his other two univer- candidate for the Rhodes Scholarship. sities. He thought of himself as part of this He distinguished himself as a scholar school. and built up a reputation of nimble-footed- The . Medical profession in Australia ness by gaining blues for Rugby and attracted a better type of student than in Athletics. England, he had found. There, Law, Arts, He graduated in Medicine in 1914 with the Church, and the Services were held in first-class Honours and in the following year higher esteem than Medicine, so that the proceeded to the Great War. During that cream of the student body was to be found campaign he was awarded the Military in other faculties. An Englishman who was Cross. associated with overseas students had told He came to Melbourne as Professor of him that Australian doctors chosen to go Pathology in 1924. As a professor in the overseas were "world-beaters," as their Melbourne University he has held the records showed. highest positions—five times president of the With the appointment of Professor King M.S.S.!!—Dean of the Medical Faculty, and to the chair of Pathology, all the professors Acting Vice-Chancellor of the University. and Stewart lecturers would be graduates We have had, then, a man of many parts of Australian universities. Whether or not guiding this - medical school for the past this was in all ways desirable, it was quarter of a century. healthy sign that Australian universities SPECULUM 9
Were making their mark, since it was purely boundaries, to enter more into the life of by the chance that the best men available the community. Thus the Medical School Were Australian graduates. He had the should extend more into the hospitals of utmost confidence in the staff. the city. The future of this University, as of others, The professor then modestly thanked us lay not so much in expansion within its for our gift, which, he was sure, he would own grounds, but in extension of its present find of great use.
APPOINTMENT : Professor E. S. J. King
The Council at its August meeting lieutenant-colonel in command of an Aus- appointed to the Chair of Pathology, soon tralian General Hospital. He was appointed to be rendered vacant by Professor to his present post of Pathologist at the MacCallum's retirement, Dr. E. S. J. King, Royal Melbourne Hospital early in 1947. Pathologist at the Royal Melbourne Hospital. Professor King combines in an unusual Edgar Samuel John King was born in New degree first-rate ability as an operative Zealand in 1900 and educated subsequently surgeon, morbid anatomist and clinical at Melbourne High School. He matriculated pathologist, and his record since graduation in 1917 and graduated M.B., B.Sc., in 1923, has been one of sustained , brilliance. He M.D. in 1926, M.S. in 1930, and D.Sc. in has the great distinction of having been 193 3. He was appointed Stewart Lecturer in awarded, on three separate occasions, the Pathology in 1928, and Stewart Scholar in Jacksonian Prize of the Royal College of Surgery in 1935; for varying periods during Surgeons, the Alvarenga Prize of the College Professor MacCallum"s absence he has been of Physicians of Philadelphia, and the Syme appointed Acting Professor of Pathology. Prize, the latter in 1931. He is the author His clinical teaching experience in Pathology of two books on subjects as diverse as bone and Surgery has been almost continuous diseases and surgery of the heart, as well as some seventy scientific papers. since the date of his graduation, and he has There is little doubt that the University held clinical appointments at the Alfred, has secured in Professor King a successor Royal Melbourne and Children's Hospitals. worthy, by his unique personal qualities as In 1939, Dr. King enlisted in the by his great prestige in medical science, of A•A.M.C. and served in the Middle East, the tradition already set for the Melbourne Australia and New Guinea until late in 1946, Chair of Pathology by the late Sir Harry by which time he had risen in rank to Allen and Professor Peter MacCallum. SPECULUM
APPOINTMENT: Professor S. L. Townsend
The Council has appointed to the Chair He served afloat during the evacuation of Obstetrics and Gynaecology Dr. Sidney from Dunkirk, and in the Mediterranean as Lance Townsend, M.B., B.S., F.R.C.S. (E.) , senior medical officer at Port Said. In 1943 F.R.A.C.S., M.R.C.O.G., D.T.M. & H. he was promoted surgeon lieutenant- (Lond.). This Chair has been vacant since commander and in June was transferred to the death of Professor Marshall Allan in the Far Eastern Fleet, with headquarters, as 1946, and has been administered first by senior medical officer, at Colombo. Dr. Dr. W. Ivon Hayes, and since 1948, by Dr. Townsend returned to the United Kingdom J. W. Johnstone, in an acting capacity. and was demobilised in August, 1946, with Dr. Townsend completed the medical the rank of surgeon-commander. After a course in March, 1936. He went to London further year as first assistant at his old in 1938 and studied at the British Post- teaching hospital, tthe West Middlesex, he Graduate School, being admitted to Mem- returned to Australia at the end of 1947. bership of the Royal College of Obstetricians He commenced private practice as con- and Gynaecologists, and to the Diploma of sultant in Obstetrics and Gynaecology and Tropical Medicine and Hygiene in June, 1939. He was appointed a Registrar in the was appointed Demonstrator in Anatomy in Obstetrical and Gynaecological Unit of the this University in April, 1948. Dr. Towns- West Middlesex Hospital, University of end is a member of the honorary staff of London, and held the appointment for a the Women's Hospital and the Austin year until his enlistment as surgeon-lieu- Hospital. The new Professor of Obstetrics tenant in the Royal Navy. and Gynaecology is 38 years old.
OBITUARY: Dr. J. A. Larwill
The sudden death of Dr. James Alfred death came unexpectedly to many and to the Larwill on April 5 came as a great shock deep regret of all. to a wide circle of friends and associates. Educated at Brisbane Grammar School, Though he had suffered a severe cardiac Fred Larwill did not commence his medical illness in 1944 which permanently damaged course until after the First World War, when his heart, few knew it and from his cheerful he entered the Melbourne Medical School bearing none could have guessed it. His as a young ex-serviceman who had served • SPECULUM 11
overseas as a pilot with the Australian were delighted to welcome him as a full-time Flying Corps, with the rank of Lieutenant, colleague. He entered on his new duties in the Second Flying Squadron. In 1925 with rare enthusiasm and took a lively he graduated M.B., B.S., with Honours in interest in all departmental activities. He all final subjects (Medicine, Surgery and was a clear and attractive lecturer with a Obstetrics and Gynaecology), and a high personality that awakened not only interest place on the final list ensured his appoint- and respect but also affection. There is ment to the resident medical staff of the abundant testimony that his reputation stood Melbourne Hospital, where he remained for high with his students. 12 months. Following this appointment he But Dr. Larwill was more than a good entered private practice in Moreland. He instructor. He was the ideal colleague, and rapidly established himself in the community those of us who knew him well will always not only as a sound and skilful practitioner think of him as a loyal and lovable friend. but also as a wise and understanding confi- He came to the Department at a critical dant. This period of his career was passed period when attempts were being made to with conspicuous success. Despite the rebuild the staff which the war years had exacting demands of a large and busy eroded away. None could resist his sincerity, practice, Larwill managed to find time to essential friendliness and desire to help, and Maintain a close association with the medical these qualities did much to make new mem- school and his old hospital. In the former bers feel at home and to create the happy he served for many years as a part-time atmosphere which prevails in the Depart- demonstrator in Histology, and on one ment. Years in general practice had given Occasion as acting lecturer, and in the latter him a wide and deep knowledge of men as an honorary clinical assistant. He was and human affairs and he was quick to sense interested in all outdoor sports, particularly the difficulties and problems of others. We bowls and football, being for several years can only speak in the most grateful terms honorary medical officer to the Melbourne of the valuable assistance that he rendered Football Club. the Department in a variety of ways, and Driven by a strong sense of duty and of the unsparing help and encouragement responsibility to his patients, pressure of that he gave others at every opportunity, Work, particularly over the war years, took more especially the younger generation for heavy toll of his health, and in 1944 he whom he had a fond attachment. We deeply suffered the severe illness which terminated regret that he was not permitted to remain his career as a general practitioner. At longer with us as a colleague and a friend. this time there was a vacancy on the staff He is survived by his widow, two sons and of the Anatomy Department for a senior a daughter, to whom we extend our sincere lecturer in Histology and Embryology. Dr. sympathy. Larwill's long association with the Depart- —S.S. ment as a part-time officer responsible for instruction in these subjects, together with • • his numerous other qualities, made him the obvious person to fill the vacancy if his health would permit him to accept the post. We are grateful to the editor of the Fortunately this became possible. Though University Gazette Pr allowing us to reprint he was no stranger to the Department we these three items. 12 SPECULUM LYSENKO Right or Wrong
The study of heredity is of obvious relevance to Medicine, and we learn in First Year a system of laws based on the observations of Mendel (the nature of heredity) and Morgan (the mechanism). However, these laws have been loudly denied in post-revolutionary Russia, by Michurin and his follower Lysenko. In these articles the pros and cons of the controversy are discussed by Walter Schnur, B.A. (Zool.), Texas, Second Year, and Clive Pringle, B .Sc., Melb., of Fourth Year.
I: RIGHT by CLIVE PRINGLE
"It is possible, with man's intervention, to force any form of animal or plant to change more quickly in a direction desirable to man. There opens before man a broad field of activity of greatest value to him." I. V. Michurin.
The major problem with which this article for Russian agriculture. In 1898 the United deals is whether one can induce those States Department of Agriculture, hearing of hereditary changes we desire in organisms. Michurin's work, sent Professor Meyer to The question is important not only to agri- visit Michurin with an offer to purchase his culturists and geneticists, but to us as medical nursery and an invitation to work in Amer- students and future doctors, for we shall ica, such was the high regard with which be faced with the problem of hereditary Michurin's work was then held. Michurin diseases. And if, as many now suspect, the refused this offer. Following the path indi- heredity of organisms can be altered in a cated by Michurin, Lysenko and many other Neo Lamaarkian fashion, then clearly we Soviet scientists have increased our know- must completely revise our attitude towards ledge on the directive role of the environ- such diseases. ment in changing the heredity. In the following article experimental data concerning micro organisms, plants and Wheat animals will be reviewed to show that, under In recent years the experiments under- the influence of the environment, the here- taken in the Soviet Union demonstrating dity of an organism can be changed in a the conversion of winter varieties of wheat predictable fashion. to spring varieties have received considerable discussion and publicity. This work repre- SOVIET EXPERIMENTS sents an extension of Lysenko's earlier contributions on vernalisation — a pre- Within Russia, evidence pointing to the treatment enabling winter wheat to be grown possibility of the inheritance of acquired as spring wheat, but not inducing an hered- characters, and of directing the heredity of itary change. That this conversion was organisms in a desired fashion, has been effected by a modification of the vernalisa - accumulating for almost 70 years. Thus tion technique must be emphasised, other- Michurin ( 1855-1936 ) , a plant breeder, wise certain statements, critical of these produced 350 new varieties of plants useful experiments, can be misleading. Thus SPECULUM 13
Darlington (1947) writes: "He can ver- These experiments were designed to meet nalise his wheat once, and all succeeding all the criticisms levelled against similar generations will be born vernalised". Such a experiments of Magnus, 1907. claim has never been made by Lysenko; Firstly, when female rabbits had been actually the complete conversion only spayed in connection with other work they occurred following the repetition of the had never observed any evidence of regen- process over several generations. eration of ovarian tissue — they remained .Discounting the distortions, the major sterile with no sign of ovarian activity. criticism against this work was that Lysenko Secondly, the mesovarium of the rabbit had used grain initially heterogeneous in its was sufficiently distinct to enable them to resistance to the treatment, i.e., that Spring completely remove an ovary. wheat existed as an impurity in the winter Thirdly, when a 1/4 - 1/2 of the original wheat; thus his pre-treatment was purely a mass of ovarian tissue was deliberately left, screening process which the resistant grain atrophy rather than regeneration of an ovary survived. In answer to this Simanskii from the remaining tissue occurred. (1940) and Kononenko (1942) claimed Fourthly, purity of the material, so far that all or most of their grain survived the as colour was concerned, was controlled by treatment. However, the crucial experiments using albino rabbits. Of Stoletov (1948) answer these criticisms. Hence the most sensible conclusion is that Firstly, he demonstrated the conversion of the ovary of the albino has undergone a winter wheat to spring wheat with single change in its heredity as a result of the grains, thus answering the objection of selec- influence of the body of the black recipient. tion of pre-adapted wheat. Secondly, the new spring wheats differed in several Physiological characters from the normal Vegetative Hybridisation spring wheat, and only became typical spring The final series of Russian experiments to wheat after sowing for several generations be quoted are those on vegetative or graft as spring wheat. Thirdly, the occasional late hybridisation. This technique was originally ears produced by spring-sown winter wheat used by Michurin when he desired to obtain do not give rise to spring wheat, which fertile hybrids from a sexual crossing which, answered the suggestion by Ashby that if done directly, would yield sterile hybrids. Partial vernalisation of the seed occurred Thus he grafted, for example, slips of moun- On the plant (Huxley, 2). tain ash (scion) on the to the pear (stock) and found that on subsequent pollination effected between the stock and scion fertile Rabbits hybrids were obtained. What was more Working with rabbits, Barasnikov, Zaks important, however, was the observation that and Pavlov (1950) have shown that if an changes induced in the scion under the ovary is transferred from one rabbit to a influence of the stock could be transmitted previously spayed female, then the progeny in subsequent sexual hybridisation. Isayev of the latter displayed unmistakeable evi- (1948) related that the fruit of the apple- dence of an effect of the recipient's body pear vegetative hybrid acquired a particular on the heredity of the transplanted ovary. character—pear-shaped apples—as a result In their experiment they transferred the of grafting. When these apples were crossed ovaries of an albino rabbit to a spayed with other varieties of apples, this character black female which, when subsequently appeared among the progeny. In these Mated with an albino buck, gave the follow- crosses the apple-pear hybrid was chosen as ing results: the paternal partner so as to obviate the 1st litter-1 albino, 1 black. slight differences known to arise between the 2nd litter-1 albino, 1 black. progeny of reciprocal crosses. (Two indi- 3rd litter-0 albino, 3 black. viduals each homozygomus with respect to 4th litter-0 albino, 3 black. character A and B can be crossed in two 14 SPECULUM ways. A female-B male and A male-B through the use of different varieties by female. Some small differences attributable workers outside the Soviet Union. Thirdly, to material inheritance are seen between the the experiments undertaken to test Lysenko's progeny of the two crosses). claims have a very recent history. Possibly Hence a hereditary change had been our friends who portray Soviet geneticists as induced in the scion (apple) under the incompetent would do better to practise a influence of the stock, there being no sexual little humility by admitting that they them- crossing as cross pollination had been selves have yet to gain competence in the prevented. use of these techniques. These experiments have been criticised In concluding this section on Soviet evi- from various angles: dence, it is interesting to note that the 1—genetic purity of the components; problem of vegetative hybridisation is still 2—the possibility of grafting chimeras confusing non-Soviet geneticists so much which result from the growth of the cells that, while denying any modification of of one into the other; heredity, they admit there are instances of 3—non-statistical treatment of data and such changes; thus Huxley (2) produces failure to set up controls; evidence from beans. 4—the inability of the other workers to get similar results. NON-SOVIET EXPERIMENTS These criticisms are extremely patronising and serve to cast doubts on the competence In this next section, instances of inheri- of Soviet geneticists and Soviet science in tance of acquired characteristics will be general, for Soviet biologists, specialising in reviewed in the works of non-Soviet scien- genetics, received experience in their courses tists. These examples are taken from the of other biological subjects where scientific genetics of skin and bacterial adaptation to procedure and methods are taught. The new substrates and drugs; in addition, a set suggestion that they fail to use variation of observations on Paramoecia, which indi- statistics is likewise false. Noudjin pointed cate the occurrence of hereditary differences out that Gluschenko's monograph on vege- not attributable to differences in genes or tative hybridisation, published in 1948, plasmagenes, will be presented. contains all the necessary evidence to show that even prior to the erudite criticism of Skin Huxley, Hudson, Richens, and their ilk, The epidermal cells of the skin are Soviet geneticists used variation statistics. generally believed to be of unitary origin, As for Soviet scientists not having heard i.e., they are all derived from the basal about control experiments, I leave that to germinative layer, the Malpighian layer. This the reader's intelligence. is incorrect. The cells of the epidermis of That other plant workers are unable to man, the guinea pig, and the pig, consist of repeat these experiments on vegetative cells of two distinct genera, the Malphigian hybridisation is not damning. Firstly, the system and the Epidermal Glial System Soviet geneticists have done more in this (dendritic cells). This discovery was made field in the past 20 years than the rest of by Langerhans in 1868 and has been the world combined; if western geneticists frequently confirmed, e.g., Becker, 1927). deny vegetative hybridisation, then one would In pigmented skin, the dendritic cells are hardly expect their literature to abound the sole origin and seat of pigmentary with experiments designed- to achieve activity, as shown by Billingham, 1948, and this. Secondly, Michurin laid down certain Bilingham and Medawar, 1948. The den- principles about vegetative hybridisation, the dritic cells may be further classified accord - result of more than 50 years' experience; ing to the colour of the pigment which they he stressed that results were not always produce—black, brown, red, sepia, etc., or obtained easily, but persistence was required. no pigments at all. These differences are Almost certainly difficulties would arise hereditary ones, i.e., they are conserved