34Th Meeting of the Associated Professional Sleep Societies, LLC

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34th Meeting of the Associated Professional Sleep Societies, LLC

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Can’t attend? All Virtual SLEEP 2020 general sessions will be available for purchase starting October 1, 2020. Visit sleepmeeting.org Dear Virtual SLEEP 2020 Attendee, speaker Q&A and a product showcase featuring information from exhibitors about their products and services. Welcome to the 34th annual meeting of the Associated Professional Sleep Societies (APSS)! Thank you for joining What makes SLEEP unique is the coming together of a us for the first-ever Virtual SLEEP meeting. I appreciate your diverse group of people with a shared passion for sleep and patience as we have navigated the obstacles presented by circadian science. Even though we aren’t physically together, the coronavirus pandemic, and I assure you that this meeting we’ll still be able to interact with the leading researchers is going to be worth the wait! and clinicians in the sleep field. While you have a choice of when and where you access Virtual SLEEP, I hope you’ll join The APSS is fortunate to be able to leverage the expertise of us for the plenary session livestream on Thursday, Aug. 27, online meeting providers, our organizations’ staff, and our which will feature keynote speaker Dr. David Holtzman, who Program Committee to bring Virtual SLEEP 2020 directly to you. will discuss his research exploring the relationship between The meeting includes live and on-demand programming, virtual sleep and Alzheimer’s disease. We’ll also honor this year’s exhibit and poster halls, and access to event recordings for recipients of awards from the American Academy of Sleep nearly a year. As a virtual attendee, you’ll have access to all the Medicine (AASM) and the Sleep Research Society (SRS). sessions, speakers, presentations and exhibitors that make this the premier meeting in our field. This year has presented challenges to all of us, both personally and professionally. Now is the time for us to be While adapting the SLEEP meeting to a virtual event, we refreshed and recharged as we learn from one another and took advantage of this opportunity to incorporate timely celebrate the incredible work being done by our colleagues programming into the schedule. We are pleased to offer across the country and around the world. On behalf of the several presentations borne out of the pandemic, as APSS Program Committee, I’m so glad you’ve joined us, and real-time research has enabled us to study the effects of I’m excited for you to experience Virtual SLEEP 2020! COVID-19 on sleep and circadian health, research, education, and the practice of sleep medicine. We’ll also pay tribute to “the Father of Sleep Medicine,” Dr. William C. Dement, who passed away in June at the age of 91. His contributions are Sincerely, too numerous to list here, but his impact on the sleep field was vast, and his legacy will be long-lasting.

Our speakers have been understanding and accommodating as we have shifted to this online format, and the APSS is grateful for their eager participation. You’ll be able to watch live and recorded general sessions, purchase access to all of the recorded postgraduate courses, and browse the poster hall and exhibit hall anytime during the virtual meeting. The Anne Germain, PhD online format also allows us to offer new features like a Chair, APSS Program Committee

VIRTUAL SLEEP 2020 GUIDE | 4 | Table of Contents ACCESS MORE SLEEP EDUCATION THAN EVER AT VIRTUAL SLEEP 2020

The shift to a virtual SLEEP meeting gives attendees translational science at the University of Pittsburgh. more opportunities to view presentations and the “The quantity and quality of the work being presented latest research, while still being able to interact with is exceptional.” colleagues and friends from around the world. The 34th annual meeting of the Associated Professional Hot topics include sleep disparities, artificial Sleep Societies (APSS) goes virtual for 2020. From intelligence in sleep medicine, adolescent sleep and August 27-30, connect with sleep care providers and circadian timing, and innovations in the management researchers in sleep medicine and circadian science. of hypersomnia. Dr. Germain said attendees won’t They might be down the street or halfway around the want to miss keynote speaker David Holtzman, MD, world, but their goal remains the same: to stay abreast who will discuss his research into the relationship of the latest research, developments and clinical between sleep and Alzheimer’s disease during applications in the sleep field. Thursday’s plenary session. “A lot of Dr. Holtzman’s work is looking at how sleep contributes to brain health and brain diseases,” she said. “There’s a lot of media attention on how sleep is really critical for brain health, for children’s development and academic performance, and at the other end of aging. It seems like the better your sleep, the better your brain health, even long-term.”

The virtual plenary session also will include recognition of the AASM and SRS 2020 award recipients and special tributes to sleep leaders we lost in the past year, including William Dement, MD, PhD, Christian Guilleminault, MD, and Mark Mahowald, MD. A special musical guest also will give you a preview of the virtual Blues Night Tribute to Dr. Dement, which will be held Whether your interests lie in clinical sleep science and Saturday evening, Aug. 29. practice, basic and translational sleep and circadian science, or sleep technology, the virtual SLEEP meeting Shifting from an in-person to virtual meeting gave offers you an opportunity to delve into current the APSS Program Committee an opportunity to developments in sleep medicine and new directions in incorporate the most current discoveries into sleep- sleep and circadian research. related issues linked to the coronavirus. Three sessions will tackle how the pandemic has impacted sleep, mental health and sleep in health care workers, and sleep medicine services. Recorded sessions will be available Poster presentations will be available for review until Aug. 1, 2021, so you can throughout the meeting, and attendees can browse the virtual exhibit hall and schedule appointments to continue to view sessions well after meet virtually with company representatives to learn the meeting has ended. more about their products and services. Virtual SLEEP attendees can download the meeting app by searching for “SLEEP meeting” in your app “The APSS Program Committee took care to focus store. There, you can review the Virtual SLEEP schedule education sessions on innovations in the specialty of events, build a personal calendar and connect with and areas of increased awareness around sleep and other attendees. circadian health,” said Chair Anne Germain, PhD, professor of psychiatry, psychology, and clinical and

VIRTUAL SLEEP 2020 GUIDE | 5 | Table of Contents SLEEP is the premier world forum to present and discuss the latest developments in clinical sleep medicine and sleep and circadian science.

Program Committee Anne Germain, PhD, Chair University of Pittsburgh School of Medicine (on leave) Providing evidence-based education to advance the PITTSBURGH, PA science and clinical practice of sleep medicine Alon Y. Avidan, MD Disseminating cutting-edge sleep and circadian research University of California, Los Angeles, translating basic science into clinical practice Department of Neurology LOS ANGELES, CA Fostering the future of the field by providing career Daniel Barone, MD development opportunities at all levels Weill Cornell Medicine NEW YORK, NY

Romy Hoque, MD Emory University What’s Inside ATLANTA, GA

Virtual Sleep Store...... 9 Elizabeth Klerman, MD, PhD Massachusetts General Hospital/Harvard General Information...... 10 Medical School BOSTON, MA Invited Lecturers...... 14 Shalini Paruthi, MD St. Luke’s Hospital Sponsors and Corporate Supporters...... 17 SAINT LOUIS, MO

Award Recipients...... 19 Rebecca Spencer, PhD University of Massachusetts Amherst In Memoriam...... 24 AMHERST, MA Sigrid Veasey, MD Q&A with Dr. David Holtzman...... 27 University of Pennsylvania, Sleep Division PHILADELPHIA, PA Schedule at a Glance...... 30 Julio Fernandez-Mendoza, PhD, Postgraduate Courses...... 36 Psychologist Reviewer Penn State College of Medicine Industry Supported Events...... 40 HERSHEY, PA Kenneth Wright, PhD, SRS Board Liaison Late Breaking Abstracts...... 42 University of Colorado BOULDER,CO Exhibitors...... 46 James Rowley, MD, AASM Board Liaison Wayne State University School of Medicine DETROIT, MI

Steve Van Hout, Executive Director

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VIRTUAL SLEEP 2020 GUIDE | 8 | Table of Contents Virtual Sleep Store General Information Information

Exhibit Hall Virtual SLEEP 2020 Store The Virtual SLEEP 2020 exhibit hall showcases Visit the Virtual SLEEP Store where attendees can virtual booth displays of pharmaceutical companies, receive special discounts on AASM and SRS products equipment manufacturers, medical publishers, and to continue their education in sleep long after the software companies. meeting! Exhibit Hall Hours Terms of Use The Exhibit Hall will be open 24/7 with dedicated Virtual SLEEP 2020 content is for individual use only attendee engagement time scheduled from 12:15 PM - and is not transferable. 2:00 PM Central and 4:45 PM - 6:00 PM Central, Friday (8/28) through Sunday (8/30). Agreement to Online Conduct SLEEP provides a welcoming environment to all Press participants. The Associated Professional Sleep Members of the press are encouraged to utilize the virtual Societies, LLC (APSS) reserves the right to rescind press room on www.sleepmeeting.org. The press room has access for those who disrupt the meeting or diminish resources to assist reporters with their stories, including the learning environment for others. detailed information on the participating organizations and study abstracts. Reporters can contact the APSS public Online Recording and Visual Capture relations staff for assistance in scheduling an interview with by the APSS presenters and abstract authors. Webinars, virtual sessions, or courses may be recorded Corinne Lederhouse, Communications Coordinator, or captured by APSS or its agents in any form of [email protected] media by and with the consent of APSS for eventual

Approved - Becky General Information

resale or other commercial or non-commercial use. SLEEP 2020 Abstract Supplement As a registered participant joining or attending a All abstracts from SLEEP 2020 are published in an webinar, virtual session or course, you consent to such online abstract supplement of the journal SLEEP. recording of the live event, which may include your To view these abstracts, visit www.sleepmeeting.org/ participation and interaction. abstract-supplements. Recording and Visual Capture Claim Credit by Attendees To claim credit from the meeting, complete the No participant may make audio or video recordings of evaluation for each session you attend within the Virtual SLEEP sessions. website or mobile app. The deadline to claim credit is August 6, 2021. Individuals who have not claimed Postgraduate Courses their continuing education credits by this date will The SLEEP general registration fee does not include be unable to do so. More information is available at access to the on-demand Postgraduate Courses. sleepmeeting.org/continued-education. You must purchase admission to access any SLEEP 2020 Postgraduate Courses. Postgraduate Course We Want Your Feedback - registrants will have access to purchased courses until Help Improve SLEEP August 1, 2021. Purchase a Postgraduate Course or all All attendees are requested to evaluate the conference courses with a discounted bundle here. overall on August 30 after the close of the last session. The survey feature will close on September 12, 2020. The APSS Program Committee will use this information to plan future events.

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VIRTUAL SLEEP 2020 GUIDE | 13 | Table of Contents Invited Lecturers Lecturers

Steven A. Brown, PhD KEYNOTE SPEAKER Professor of Chronobiology and Sleep Research, University of Zurich David M. Holtzman, MD Molecular and Circuit Aspects Professor and Chair of Neurology, Scientific Director of the Hope Center of Circadian Sleep Regulation for Neurological Disorders, and Steven A. Brown, PhD, conducted Associate Director of the Knight ADRC, undergraduate research in Washington University in St. Louis yeast genetics and graduate studies on chromatin Sleep and Alzheimer’s Disease: Bi-Directional biochemistry at Harvard. He then moved to Geneva Relationship With Amyloid-ß and Tau for postdoctoral work, where he first studied biological Some of Dr. Holtzman’s lab’s accomplishments include clocks and sleep in the laboratory of Ueli Schibler. After showing in part how apoE4 contributes to Alzheimer’s a stay at Charité Universitätsmedezin as a Humboldt disease (AD), development of a method to measure fellow, Brown returned to Switzerland in 2007 as protein synthesis and clearance in the CNS of animals an assistant professor and then professor. Brown’s and humans, development of CSF biomarkers for AD, laboratory studies the molecular mechanisms and and development of an anti-Aβ and an anti-tau antibody neural circuits underlying sleep and diurnal behavior, now in clinical trials for AD. Holtzman is a past president using human cells and mouse models. By biochemically of the American Neurological Association and has trained fractionating cortical synapses, his lab has shown how more than 50 graduate students, post-doctoral fellows, sleep and circadian influences cooperate to regulate and physician-scientists, many of whom have gone on to the synaptic dynamic. successful careers in academia and industry. Chandra L. Jackson, PhD Earl Stadtman Investigator, National Institute of Environmental Health Sciences Richard B. Berry, MD National Institute on Minority Professor of Medicine, University of Florida Health and Health Disparities Medical Director, University of Florida Health Sleep Disorders Center Sleep Disparities: Refining the The Future of Scoring/PSG Narrative to Ask Informative Richard B. Berry, MD is a Research Questions staff physician at the Malcom Chandra L. Jackson, PhD leads the Social and Randall VA and the director of the UF Sleep Medicine Environmental Determinants of Health Equity Research Fellowship. Berry served as a member of the AASM group in the Epidemiology Branch of the National Board of Directors, as president of the AASM Institute of Environmental Health Sciences with a joint Foundation, and is the current deputy editor of the appointment in the National Institute on Minority Journal of Clinical Sleep Medicine. He received the Health and Health Disparities. Jackson investigates AASM Excellence in Education Award in 2010 and the physical and social environmental factors that impact Stuart Quan Award for Editorial Excellence in 2019. disparities in sleep health and subsequent risk of His research interests include home sleep apnea cardiometabolic dysfunction, including obesity and testing, treatments for obstructive sleep apnea type 2 diabetes. Her research has been presented at including positive airway pressure, and facets of national scientific conferences and published in both polysomnography technology. academic journals like Lancet, JAMA Internal Medicine, the American Journal of Epidemiology, and SLEEP as well as major media outlets such as the US News & World Report and The New York Times.

VIRTUAL SLEEP 2020 GUIDE | 14 | Table of Contents Invited Lecturers

Nita Shattuck, PhD THOMAS ROTH Professor, Naval Postgraduate School in Monterey, CA LECTURE OF EXCELLENCE Sleep in the Wild: Mary A. Carskadon, PhD Studying Sleep on the Professor, Warren Alpert Medical School of Brown University High Seas and Beyond Director, Chronobiology and Sleep Nita Shattuck, PhD teaches Research Laboratory at Bradley Hospital courses in human factors engineering and human systems integration, directs Adolescent Sleep, Sleepiness, and Circadian Timing thesis research, and pursues her research interests Mary A. Carskadon, PhD’s early research with in human fatigue in operational settings, individual her graduate mentor, William C. Dement, and team performance, decision-making, and military culminated in the development and application command and control. In her work with the military, of a standardized measure for daytime sleep Shattuck has studied the effects of fatigue, sleep tendency, the multiple sleep latency test. A major deprivation, thermal stress, and acceleration in various focus of Carskadon’s scientific activities is research operational and laboratory environments. She served examining interrelations between the circadian as advisor to the President’s Emergency Operations timing system and sleep/wake patterns of children, Center of the White House, documenting improvements adolescents, and young adults. Carskadon has in sleep and morale following adoption of a novel received awards from several national organizations watchbill. Her work has resulted in sweeping changes recognizing her scientific, educational, and public to U.S. Navy policy that now mandates the use of policy contributions. She is an elected Fellow of the circadian-based watchbills and emphasizes benefits of Association for Psychological Science and crew rest practices. of the American Association for the Advancement of Science. Phyllis Zee, MD, PhD Chief of the Division of Sleep Medicine, Northwestern University Feinberg School of Medicine Rachel Manber, PhD Professor, Northwestern University Professor, Stanford University Director, Center for Circadian and Sleep Medicine School of Medicine Circadian Medicine: Journey Cognitive Behavioral Therapy Through Time for Insomnia: New Frontiers Phyllis C. Zee, MD, PhD is the founder of the first Rachel Manber, PhD, DBSM has circadian medicine clinic in the U.S., where innovative conducted clinical sleep research treatments are available for patients with circadian focused on cognitive behavioral rhythm disorders. Zee is a past president of the Sleep therapy for insomnia (CBTI) in specific populations, Research Society, a fellow of the American Academy including insomnia comorbid with depression, of Sleep Medicine, fellow of the American Academy of insomnia comorbid with sleep apnea and perinatal Neurology and member of the American Neurological insomnia. She led the development of a nationwide Association. She is the recipient of the 2014 American dissemination project in the VA for training licensed Academy of Sleep Medicine William C. Dement mental health providers to deliver cognitive behavioral Academic Achievement Award. therapy for insomnia. Her current research focuses on issues related to enhancing broad implementation of CBTI, including the use of stepped care strategies.

VIRTUAL SLEEP 2020 GUIDE | 15 | Table of Contents Sleep Walking Go SLEEP Walking in the Exhibit Hall starting August 28!

» Scan exhibitor QR codes through the mobile app and correctly answer as many scavenger hunt questions as possible and see your name rise to the top of the leaderboard!

» Find the SLEEP Walking QR codes scattered around the Exhibit Hall, SLEEP Store and throughout the virtual meeting website.

» The top 3 contestants on the leaderboard will win the following prizes. Winners will be notified September 5th.

1st Place $750 Amazon Gift Card & Free 2021 AASM or SRS Membership 2nd Place $250 Amazon Gift Card & Free 2021 AASM or SRS Membership MEMBERSHIP 3rd Place $100 Amazon Gift Card & Free 2021 AASM or SRS Membership

Participating exhibitors as of 7/31/20:

VIRTUAL SLEEP 2020 GUIDE | 16 | Table of Contents In Memoriam Sponsors and CorporateTHANK Supporters YOU TO OUR As of VIRTUAL SLEEP 2020 SPONSORS! 7/31/20

Platinum

Silver

Premium Exhibitor

AASM Foundation Ectosense Group/Sleep Company S.L.P./SleepSense Advanced Brain Monitoring EnsoData, Inc. Sizewise American Academy of Sleep General Sleep Corporation Sleep Research Society Medicine Inspire Medical Systems Sleep ISR Arbor Pharmaceuticals, LLC Jazz Pharmaceuticals SleepStation BioSerenity, Inc. Metro Health U of MI SleepTM Brain Vision Nonin Medical, Inc. SNUGZ Mask Liners Cadwell Industries, Inc. Oxford University Press Somnoware Healthcare Systems CleveMed Respicardia SRS Foundation Compumedics Rhythmlink Virtuox, Inc.

Preferred Exhibitor

Brain Electrophysiology Lab (BEL) Company UCLA Health Infotrust Corporation Vanda Pharmaceuticals, Inc. Pear Therapeutics World Sleep Society Takeda Pharmaceuticals Intl., Co

VIRTUAL SLEEP 2020 GUIDE | 17 | Table of Contents

Award Recipients Award Recipients Meet Your 2020 SRS Award Recipients

The Sleep Research Society has selected three outstanding sleep and circadian scientists as recipients of the 2020 Sleep Research Society awards, which recognize excellence in sleep and circadian research.

PHYLLIS C. ZEE, MD, PHD RICHARD P. ALLEN, PHD Distinguished Scientist Award for significant, Outstanding Scientific Achievement Award original and sustained scientific contributions for novel and seminal discoveries of a basic, of a basic, clinical or theoretical nature to the clinical or theoretical nature that have made a sleep and circadian research field, made over an significant impact on the sleep field. entire career. Dr. Allen is a professor in the department Dr. Zee is the Benjamin and Virginia of neurology at the Johns Hopkins T. Boshes Professor of Neurology and professor of University School of Medicine. He founded and neurobiology at Northwestern University in Chicago, co-directed the Sleep Disorders Center and the Center Illinois. She is also the director of the Center for Circadian for Restless Legs Syndrome at Johns Hopkins. He and Sleep Medicine (CCSM) and chief of the Division of also served as chair of the medical advisory board for Sleep Medicine at Northwestern University’s Feinberg the Restless Legs Syndrome Foundation, chair of the School of Medicine. Dr. Zee is the founder of the first International Restless Legs Syndrome Study Group, and circadian medicine clinic in the U.S., where innovative president of the World Association of Sleep Medicine treatments are available for patients with circadian (now World Sleep Society). He had a central role in rhythm sleep-wake disorders. She is a fellow of both defining the current diagnostic standards for RLS and the the American Academy of Sleep Medicine and American new standards for iron treatments of RLS and scoring Academy of Neurology, and she is a member of the periodic limb movements. He has published more than American Neurological Association. She is the recipient of 300 peer-reviewed articles on sleep disorders including the 2014 American Academy of Sleep Medicine William C. pioneering work on RLS augmentation, dopamine and Dement Academic Achievement Award. intravenous iron RLS treatments.

“It is an immense honor to receive this award. It “I’m honored and humbled to receive this very prestigious represents the recognition and appreciation of the award from the Sleep Research Society. I’ve spent the significant role circadian rhythms have on sleep and last 40 years with a singular focus, studying and thinking nearly all biological functions, and especially how the about restless legs syndrome. Maybe it seems tiresome to work performed by the many talented scientists and be so exclusively focused on only one sleep disorder, but distinguished collaborators in the field have helped rather than boring drudgery, it’s been a privilege and one translate this knowledge into clinical medicine. I want to hell of an exciting adventure in discoveries. I have had thank members of my laboratory, the SRS board and my the privilege of working with many wonderful colleagues, colleagues who nominated me for this award.” particularly Diego Garcia-Borreguero and John Winkelman and others, far too many to name. But most important - Phyllis C. Zee, MD, PhD has been the uniquely close and remarkably productive 30-year collaboration I have had with Christopher Earley. The work would not have continued without him. I feel this award belongs as much to Chris as to me.”

- Richard P. Allen, PhD

VIRTUAL SLEEP 2020 GUIDE | 19 | Table of Contents Meet Your Your 2020 2020 SRS SRS Award Award Recipients Recipients

ALLAN I. PACK, disorder, obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been MBCHB, PHD listed in the Best Doctors in the United States and in Mary A. Carskadon Outstanding Educator Award the Philadelphia region (Philadelphia Magazine). Dr. for excellence in education related to the sleep Pack currently directs three T32 grants from NIH to and circadian research field. support research training.

Dr. Pack is the John Miclot Professor of “One of the most important things an investigator can Medicine at the University of Pennsylvania. He was do is to take active steps to ensure the next generation the founding director of the Center for Sleep and of investigators. My colleagues and I at the University Circadian Neurobiology and the Division of Sleep of Pennsylvania have made this a major focus of our Medicine at the University of Pennsylvania. These activities over the last 30 years. Many individuals we have are the first multidisciplinary, independent sleep trained are in faculty positions in multiple institutions in research and clinical sleep medicine programs to the United States and Canada. We have sought to do our be established at any medical school in the United part to ensure a robust pipeline of new investigators.” States. Dr. Pack’s current area of focus is on functional genomic approaches to sleep and its disorders. - Allan I. Pack, MBChB, PhD A major component of his research relates to the pathogenesis and consequences of the common

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Why Join the SRS? Join the SRS and receive:

An SRS membership is not only a vital tool for your • Education and training opportunities career growth, but also to help support and grow with leaders in the field sleep and circadian research. For over 50 years, the • Significant discount on SRS meeting Sleep Research Society (SRS) has equipped scientists registration fees to maximize their professional potential. • Full access to the archives of SRS publications including Journal SLEEP and SLEEP Advances Today, the SRS continues to advance the investigation of sleep and sleep disorders, promote training and education • Advocating for increasing NIH research dollars in sleep research, and provide forums for the exchange • Opportunity to apply for grants and awards that of knowledge pertaining to sleep and circadian research. recognize and support outstanding sleep research

VIRTUAL SLEEP 2020 GUIDE | 20 | Table of Contents sleepresearchsociety.org/membership/ Meet Your 2020 AASM Award Recipients

Several leaders in the field of sleep medicine and two members of Congress are recipients of the 2020 American Academy of Sleep Medicine awards. RICHARD B. BERRY ATUL MALHOTRA, MD, FAASM MD, FAASM William C. Dement Academic Achievement Award for exceptional initiative and progress in the Nathaniel Kleitman Distinguished Service Award areas of sleep education and academic research. for dedication to the sleep field and significant contributions in the areas of administration, Dr. Malhotra is a pulmonary, critical public relations and government affairs. care and sleep medicine physician at Dr. Berry is professor of medicine at the the University of California San Diego University of Florida in Gainesville, medical director School of Medicine. His research interests include of the UF Health Sleep Center and director of the UF the pathogenesis of obstructive sleep apnea and the Sleep Medicine Fellowship. He also is a staff physician pathophysiology underlying its complications. He runs at the Malcom Randall VA Medical Center. Dr. Berry is a large NIH-funded laboratory and is the author of deputy editor of the Journal of Clinical Sleep Medicine, more than 500 research articles, books, chapters and past president of the AASM Foundation, and served reviews. A highly sought-after expert in sleep medicine, on the AASM Board of Directors. He was chair of Dr. Malhotra has delivered hundreds of lectures in the the AASM Sleep Apnea Definitions Task Force, the U.S. and around the world and has appeared in dozens NPPV Titration Task Force and the AASM Scoring of media reports on sleep and sleep disorders. Manual Editorial Committee. Dr. Berry received the “I am honored to receive this recognition, which I accept AASM Excellence in Education Award in 2010 and the on behalf of my team including countless clever mentees Stuart Quan Award for Editorial Excellence in 2019. and collaborators who have been the brains and energy He served on the first American Board of Internal behind the progress we have made. I often paraphrase Medicine Sleep Medicine Test-Writing Committee Michael Jordan with, ‘There is no I in team,’ and Harry and wrote “Sleep Medicine Pearls,” a popular sleep Truman with, ‘It is amazing what you can accomplish medicine textbook. His research interests include if you do not care who gets the credit.’ I feel like we are home sleep apnea testing, treatments for obstructive in the early stages of understanding sleep and sleep sleep apnea including positive airway pressure, and disorders, so I am excited to see what we all learn in the polysomnography technology. coming years.” “I am deeply honored to be selected for the AASM 2020 - Atul Malhotra, MD, FAASM Nathaniel Kleitman Award. It has been my pleasure to work with many dedicated sleep physicians and AASM staff members over the years and to contribute to the growth of sleep medicine. I am fortunate to have practiced sleep medicine for over 35 years and continue to find it a challenging and rewarding experience.”

– Richard B. Berry, MD, FAASM

VIRTUAL SLEEP 2020 GUIDE | 21 | Table of Contents Meet Your 2020 AASM Award Recipients

MADELEINE M. GRIGG- REPRESENTATIVE DAMBERGER, MD, FAASM ZOE LOFGREN AND Excellence in Education Award for outstanding REPRESENTATIVE contributions in the teaching of sleep medicine. RODNEY DAVIS Dr. Grigg-Damberger is professor of neurology at the University of New Mexico Mark O. Hatfield Public Policy or Advocacy Award for developing School of Medicine where she also serves public policy that positively affects as medical director of Pediatric Sleep Medicine Services, the healthy sleep of all Americans. associate director of the Clinical Neurophysiology Laboratory Representatives Zoe Lofgren (D-Calif.) and Rodney Davis (R-Ill.) and program director of the Clinical Neurophysiology are sponsors of the Sleep Health Caucus in the U.S. Congress. Fellowship Training Program. A member of the editorial Their leadership will guide the prioritization of sleep health at board of the Journal of Clinical Sleep Medicine, Dr. Grigg- the federal level to support the AASM in advancing sleep care Damberger also helped develop the AASM criteria for and enhancing sleep health to improve lives. Rep. Lofgren also recording and scoring polysomnography in adults, children, sponsored the “ZZZ’s to A’s Act,” a House Bill directing the U.S. and most recently, infants. Department of Education to study the relationship between “I teach what I learn. The growing breadth, complexity, and school start times and adolescent health, well-being and intricacies of sleep medicine continue to captivate me. I study, performance. Studies show that later school start times help put what I learn into clinical practice, see what works and reduce tardiness, enhance academic performance and improve makes sense, then teach what I learn to others. Observing the teen driving safety. achievements, accomplishments and successes of those I have “Receiving adequate sleep is important to the health of taught has given me pleasure and pride. I am grateful to the individuals at all ages. I am grateful to receive the 2020 AASM American Academy of Sleep Medicine, my favorite academic Mark O. Hatfield Award and look forward to working with home for 35 years, a place of collegial colleagues, eager and Chairperson Lofgren in leading the Sleep Health Caucus.” earnest fellows, forward thinking, and congenial collaboration.” – Representative Rodney Davis - Madeleine M. Grigg-Damberger, MD, FAASM

VIRTUAL SLEEP 2020 GUIDE | 22 | Table of Contents

In Memoriam In Memoriam IN MEMORIAM

The American Academy of Sleep Medicine and Sleep Research Society remember the mentors, colleagues, and friends who have passed away in the time since we met last June in San Antonio for SLEEP 2019. We are grateful for their many contributions to the fields of sleep medicine and sleep and circadian research.

William C. Dement, MD, PhD Christian Guilleminault, MD

“The Father of Sleep Medicine,” Dr. As both a clinician and scientist, Dr. Dement was the founding president Guilleminault played a foundational of the AASM, serving in the position role in the establishment and for 12 years, and he played a pivotal development of the field of sleep role in establishing the SRS. His medicine. In 1970 he opened one of lifetime of sleep discoveries began at the world’s first sleep disorders centers the University of Chicago in the 1950s, where he and in Paris, and in the early 1970s he helped Dr. Dement physiologist Nathaniel Kleitman described the human establish the first full-service sleep disorders clinic in the sleep cycle and its sleep stages, and they explored the U.S. at Stanford University. He helped the AASM and SRS relationship between REM sleep and dream activity. At develop the first Diagnostic Classification of Sleep and Stanford University, where he spent the entirety of his Arousal Disorders in 1979. A renowned sleep researcher, career, he opened one of the world’s first sleep disorders he made significant contributions to the understanding clinics in 1970. As a researcher, clinician, educator, and of the physiological and endocrinological changes that advocate, Dr. Dement helped build the sleep field with occur during sleep. He and Dr. Dement also were the unrivaled passion, dedication, and enthusiasm. founding editors of the journal Sleep.

Mark Mahowald, MD Richard Kronauer, PhD Helio Lemmi, MD

Dr. Mahowald was Dr. Kronauer Born in Sao the 1992 – 1993 was the Gordon Paulo, Brazil, Dr. AASM president, McKay Professor Lemmi trained and he received of Mechanical as a neurologist numerous awards, Engineering, at the University including the 2010 SRS Outstanding emeritus, at Harvard University. of Alabama at Birmingham and Scientific Achievement Award. He was primarily known for his became a global leader in sleep He was the medical director of pioneering work in mathematical medicine and sleep research. In the Minnesota Regional Sleep biology, especially research on 1977 he founded and directed the Disorders Center, and he identified human circadian rhythms, including Sleep Disorders Center at Baptist several parasomnias along with his his 1982 paper, “Mathematical Memorial Hospital in Memphis, colleague, Carlos Schenck, MD. model of the human circadian Tennessee. He also helped establish system with two interacting the Southern Sleep Society. oscillators.”

VIRTUAL SLEEP 2020 GUIDE | 24 | Table of Contents CREATING HOPE THROUGH INNOVATION

At Eisai, everything we do is guided by a simple principle: patients and their families come first. We spend time with them. We listen and we learn about their lives, their desires and their greatest needs. We call this human health care or hhc, giving first thoughts to patients and their families and helping increase the benefits health care provides.

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This presentation is sponsored by Jazz Pharmaceuticals. Due to regulatory restrictions, this presentation is only available to attendees from the United States. This is a non-CME event. © 2020 Jazz Pharmaceuticals, Inc., a subsidiary of Jazz Pharmaceuticals plc, all rights reserved. US-SOL-2000226 Rev0720

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Register Today at sleeptm.com In Memoriam Q&A withSLEEP Dr. David ANDHoltzman ALZHEIMER’S DISEASE: Q&A WITH DR. DAVID HOLTZMAN

A world-renowned neurologist, David M. Holtzman, MD, will deliver the keynote address at Virtual SLEEP 2020, Thursday, Aug. 27. Dr. Holtzman will speak about the bidirectional relationship between sleep and Alzheimer’s disease. We caught up with the professor and chairman of the department of neurology at the Washington University School of Medicine in St. Louis to learn more about his research and get a preview of his presentation.

Dr. Holtzman, thank you, we look forward DH: My own lab is not working on the to hearing your keynote address and relationship between COVID-19 and the are glad you’ll be a part of our virtual nervous system directly. However, a number of SLEEP meeting. Before we discuss your investigators both at Washington University and research and presentation, let’s spend elsewhere are working on the potential direct just a moment on the current situation and indirect effects of COVID-19 on the nervous impacting all of us. system. We have been thinking about trying to study middle-aged and elderly people who How have you been managing through developed COVID-19 and have gotten through the pandemic? it to determine if it might have any long-term DH: In regard to research, between mid-March effects on the brain. and the beginning of May, my lab was doing a lot Tell us about your interest in neurology of data analysis and writing from home and just and Alzheimer’s research. How did this coming into the lab for essential experiments of become your life’s work? maintaining different colonies of mice that we have put years and years of effort into. By May, DH: I started getting interested in neuroscience we started back to having all the scientists back and Alzheimer’s disease (AD) when I was in in the lab but on a seven day a week schedule medical school. I remember a lecture during my with two shifts a day to carry out work with all second year of medical school in 1982 about the appropriate social distancing and other neurodegenerative diseases. At that time, we knew precautions. In terms of performing research, so little about AD, but it was around that time that we are back up to normal levels with the caveats the selective vulnerability of different parts of the listed here. brain in AD was just being described. Not only was that interesting, but it was becoming clear that for Are you shifting any of your research one of the most impactful diseases to humans, focus to COVID-19? It was thought to we knew so little. I remember thinking that this is be mainly respiratory, but now we’re really something I want to study as the potential learning COVID may have long-term impact was so great. impacts on all parts of the body.

VIRTUAL SLEEP 2020 GUIDE | 27 | Table of Contents SLEEP AND ALZHEIMER’S DISEASE: Q&A WITH DR. DAVID HOLTZMAN

We’re learning more every day about the DH: I will discuss the findings just mentioned, importance of sleep to our overall health, which describe how manipulations of the sleep- including brain health and function. Tell wake cycle acutely and chronically regulate Aβ us a bit about what you’ve uncovered in and tau levels as well as how the accumulation your research into sleep and brain health. of these proteins appears to disrupt the sleep- wake cycle. DH: Well, I kind of stumbled into the work relating sleep to AD. There are two main How can sleep scientists and researchers proteins that aggregate and accumulate in the help the medical community better AD brain that are important in AD pathogenesis, understand the role of sleep in amyloid-β (Aβ) and tau. My lab was studying Alzheimer’s and hopefully get us closer to what normally regulates the levels of these a treatment? proteins in the normal brain because one of DH: By understanding how the different aspects the things that drives them to aggregate and of sleep and wake influence the underlying accumulate is the absolute level of the normal, pathology of AD, this has the potential to provide soluble forms of these proteins. In the process of insights into novel ways to develop preventions determining this, we ended up finding that both and/or treatments for AD. extracellular levels of both proteins are directly regulated by whether one is awake or asleep. Once we found this, we have been studying how manipulating the sleep-wake cycle both acutely Thank you, Dr. Holtzman. We look forward to and chronically could alter Aβ and tau levels, hearing your presentation during the Virtual not as a consequence but as a cause of AD SLEEP 2020 plenary session, which will be pathogenesis. livestreamed at 7 p.m. CDT on Thursday, Aug. 27. Can you give us a preview of the research you’ll discuss in the Virtual SLEEP keynote address—that’s there’s a bidirectional relationship between sleep and Alzheimer’s?

VIRTUAL SLEEP 2020 GUIDE | 28 | Table of Contents Advancing narcolepsy treatment. Once and for all.

Avadel is committed to the narcolepsy community.

We’re working day and night to move narcolepsy treatment into the future. Connect with us to see how our work unfolds.

Visit booth #413 to learn more.

Bench-to-Bedside Bench to Bedside Integrated Sessions focus on the latest advances in B Integrated Sessions translational science and clinical applications on a specific topic.

Sessions based around the impact of the COVID-19 pandemic on the COV COVID-19 and Sleep fields of sleep medicine and circadian and sleep research.

Discussion Groups are forums for informal presentations of a specific D Discussion Groups topic, which may include conversations on controversial topics or pro/con discussions and presentations.

Rapid-Fire Symposia are fast-paced sessions led by junior-level F Rapid-Fire Symposia investigators/clinicians focusing on the latest data and ideas in the field.

Invited Lectures feature senior-level investigators/clinicians I Invited Lectures presenting on their areas of expertise.

Oral Presentations feature investigators presenting their latest O Oral Presentations research and new ideas in the field.

S Symposia Symposia focus on the latest data and ideas in the field.

Technologist Track is dedicated to sleep technologists and is T Technologist Track designed to accommodate all levels of sleep technologists and is valuable to all members of the sleep team.

Clinical Workshops are reviews of patient-related and business- related aspects of sleep centers. Workshops address difficult clinical W Clinical Workshops situations, business challenges, and trends that clinicians experience in their daily practices.

View more at sleepmeeting.org/schedule

Plenary Thursday, August 27, 2020, 7:00 PM – 9:00 PM CDT Keynote Speaker: David M. Holtzman, MD Sessionsleepmeeting.org Sleep and Alzheimer’s Disease: Bi-Directional Relationship With Amyloid-ß and Tau Receive the latest details

*All schedule information is subject to change. Please visit sleepmeeting.org for the most up-to-date information. VIRTUAL SLEEP 2020 GUIDE | 30 | Table of Contents AUG Session Types: I Invited Lecturers Basic & Translational Sleep and Circadian Science Track FRI | 28 O Oral Presentations B Bench to Bedside S Symposia Clinical Sleep Science & Practice Track D Discussion Groups sleepmeeting.org/schedule COV COVID-19 and Sleep F Rapid-Fire Symposia W Clinical Workshops Technologist Track

Live Sessions On Demand Sessions 9:30 AM S-01: Emerging F-01: What Can Sleep S-02: In Search of Ancestral W-01: Restless Sleep T-01: PSG Presentation 9:45 AM Technologies: More Analytics Tell Us About CNS Sleep: Human Sleep in Disorder: Diagnostic and Management: Affordable and Flexible Hypersomnia Disorders? Preindustrial Communities Criteria for a Newly Defined Hypoventilation, Restless 10:00 AM Alternatives to Actigraphs? 9:30 AM - 11:15 AM 9:30 AM - 11:15 AM Pediatric Sleep Disorder Leg, and Parasomnias 9:30 AM - 11:15 AM 9:30 AM - 11:15 AM 9:30 AM - 10:15 AM 10:15 AM Break 10:15 AM - 10:30 AM 10:30 AM T-02: Polysomnography 10:45 AM and Beyond 10:30 AM - 11:15 AM 11:00 AM

11:15 AM Break 11:15 AM - 11:30 AM 11:30 AM I-02: The Future of O-01: Pharmacotherapy COV-01: Sleeping Through O-02: New Genetic T-03: Pediatric 11:45 AM Scoring/PSG for Insomnia: Population an Emerging Pandemic, Discoveries Polysomnography 11:30 AM - 12:15 PM Use and Efficacy of Novel from Youth to the Elderly: in Sleep Disorders 11:30 AM - 12:15 PM 12:00 PM Compounds How North Americans'... 11:30 AM - 12:15 PM 11:30 AM - 12:15 PM 11:30 AM - 12:15 PM 12:15 PM

12:30 PM

12:45 PM Exhibit Hall IS OPEN! 1:00 PM Accessible 24 hours a day, you can watch Break 12:15 PM - 2:00 PM presentations, send direct messages to 1:15 PM exhibitors, have live interactions and 1:30 PM “visit” booths at your leisure.

1:45 PM

2:00 PM S-03: Novel Approaches to S-04: Artificial Intelligence S-05: The Impact of S-06: The Role of REM T-04: Careers in Sleep 2:15 PM Understanding Complex and Sleep: The Next Circadian Misalignment Sleep and REM Sleep Technology for the Sleep Determinants of Disparities Frontier on Obesity and Metabolic Dreaming in Offline Technologist/Respiratory 2:30 PM in Sleep Health 2:00 PM - 3:45 PM Health Across the Lifespan Memory Processing Therapist 2:00 PM - 3:45 PM 2:00 PM - 3:45 PM 2:00 PM - 3:45 PM 2:00 PM - 3:45 PM 2:45 PM

3:00 PM

3:15 PM

3:30 PM

3:45 PM Break 3:45 PM - 4:00 PM 4:00 PM I-03: Sleep in the Wild: O-03: It's Getting Harder F-02: Sleeping with O-04: OSA: Treatments and T-05: Sleep ISR Panel 4:15 PM Studying Sleep on the and Harder to Breathe: Our Emotions: Novel Related Issues 4:00 PM - 4:45 PM High Seas and Beyond Pediatric OSA Insights Regarding Sleep- 4:00 PM - 4:45 PM 4:30 PM 4:00 PM - 4:45 PM 4:00 PM - 4:45 PM Associated Emotion... 4:00 PM - 4:45 PM 4:45 PM Live Networking Events 4:45 PM - 6 :00 PM Hot Topic Discussions | Assemblies Exhibit Hall | Poster Hall

VIRTUAL SLEEP 2020 GUIDE | 31 | Table of Contents AUG Session Types: I Invited Lecturers Basic & Translational Sleep and Circadian Science Track SAT | 29 O Oral Presentations B Bench to Bedside S Symposia Clinical Sleep Science & Practice Track D Discussion Groups sleepmeeting.org/schedule COV COVID-19 and Sleep F Rapid-Fire Symposia W Clinical Workshops Technologist Track

Live Sessions On Demand Sessions 9:30 AM S-07: Broken Liver, Broken S-08: Phenotyping B-01: Mechanisms of S-09: Solutions for T-06: Advanced Titration 9:45 AM Sleep, Broken Thinking: OSA Based on EDS and Fatigue: From Cells to Childhood Insomnia: Protocols for the Sleep Lab Is the Key in the Clock? Cardiovascular Morbidity: Humans Diverse Approaches for 9:30 AM - 11:15 AM 10:00 AM 9:30 AM - 11:15 AM Age and Gender Effects 9:30 AM - 11:15 AM Managing Disturbed Nights 9:30 AM - 11:15 AM in Children to Improve Their 10:15 AM Days 9:30 AM - 11:15 AM 10:30 AM

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11:00 AM

11:15 AM Break 11:15 AM - 11:30 AM 11:30 AM I-04: Cognitive Behavioral O-05: OSA: Epidemiology O-06: Sleep Deprivation I-05: Sleep Disparities: T-07: Sleep-Related 11:45 AM Therapy for Insomnia: New and Diagnosis Effects on Performance and Refining the Narrative to Movement Disorders Frontiers 11:30 AM - 12:15 PM Injury Ask Informative Research 11:30 AM - 12:15 PM 12:00 PM 11:30 AM - 12:15 PM 11:30 AM - 12:15 PM Questions 11:30 AM - 12:15 PM 12:15 PM

12:30 PM

12:45 PM Exhibit Hall IS OPEN! 1:00 PM Exhibit Hall Accessible 24 hoursPoster a day, you Hall can watch Break 12:15 PM - 2:00 PM presentations, send direct messages to 1:15 PM IS OPEN! exhibitors, have liveIS interactions OPEN! and 1:30 PM “visit” booths at your leisure.

1:45 PM

2:00 PM O-07: Sleep Disorders and D-01: Assessing Fitness for B-02: Thinking Big with S-10: Overlap of Insomnia, T-08: Practical Anatomy 2:15 PM Medical Disorders Duty: What is the Role of the Sleep and Circadian RLS, and Periodic Leg and Physiology of 2:00 PM - 3:45 PM Practicing Sleep Medicine Rhythms: Leveraging Movements During Sleep: Sleep-Disordered 2:30 PM Clinician? Open Source Algorithms, Insights Breathing 2:00 PM - 3:45 PM Wearable Technology, from Human Genetics 2:00 PM - 3:45 PM 2:45 PM and Big Data 2:00 PM - 3:45 PM 2:00 PM - 3:45 PM 3:00 PM

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3:30 PM

3:45 PM Break 3:45 PM - 4:00 PM 4:00 PM I-06: Molecular and Circuit O-08: Diagnostic Tools O-09: Sorting Out Sleep for O-10: Insomnia: Natural T-09: Sleep-Related 4:15 PM Aspects of Circadian for Sleep Disorders 24/7 Professions Course and Comorbidity Neurology Disorders Sleep Regulation 4:00 PM - 4:45 PM 4:00 PM - 4:45 PM 4:00 PM - 4:45 PM 4:00 PM - 4:45 PM 4:30 PM 4:00 PM - 4:45 PM

4:45 PM Live Networking Events After Hours Event 4:45 PM - 6 :00 PM 6:00 PM Hot Topic Discussions Blues Night Tribute to Dr. Dement Exhibit Hall | Poster Hall

VIRTUAL SLEEP 2020 GUIDE | 32 | Table of Contents AUG Session Types: I Invited Lecturers Basic & Translational Sleep and Circadian Science Track SUN | 30 O Oral Presentations B Bench to Bedside S Symposia Clinical Sleep Science & Practice Track D Discussion Groups sleepmeeting.org/schedule COV COVID-19 and Sleep F Rapid-Fire Symposia W Clinical Workshops Technologist Track

Live Sessions On Demand Sessions 9:30 AM D-02: Sleep Medicine O-11: Mechanisms and W-02: Tailoring RLS D-03: Advocating for S-11: From the Lab to 9:45 AM Around the World: A Function of Sleep on Treatment Throughout the Evidence-Based Sleep the Real World: Sleep Session from the AASM Memory Next Decade: From Bench Policy: Why, How, and Who? as a Mechanism and 10:00 AM International Members 9:30 AM - 11:15 AM to Bedside 9:30 AM - 11:15 AM Intervention Target for Taskforce 9:30 AM - 11:15 AM Mood Symptoms and 10:15 AM 9:30 AM - 11:15 AM Suicidality in Adolescents 9:30 AM - 11:15 AM 10:30 AM

10:45 AM

11:00 AM

11:15 AM Break 11:15 AM - 11:30 AM 11:30 AM F-03: Sleeping with I-07: Circadian Medicine: O-12: Eyes Wide Open: O-13: OSA and Comorbid O-14: Physical Activity, 11:45 AM Our Emotions: Novel Journey Through Time Pediatric Insomnia Overlap Physical Symptoms, Insights Regarding Sleep- 11:30 AM - 12:15 PM 11:30 AM - 12:15 PM 11:30 AM - 12:15 PM Mental Symptoms, 12:00 PM Associated Emotion... and Sleep Quality 11:30 AM - 12:15 PM 11:30 AM - 12:15 PM 12:15 PM

12:30 PM

1:45 PM

2:00 PM S-12: Advances in Light F-04: The Impact of Sex COV-02: Navigating Sleep W-03: Behavioral D-04: Value-Based Sleep 2:15 PM Exposure Measurement as a Biological Variable in Medicine Services During Interventions for Adult in the Real World: Alternate and Optimal Lighting Health: the Pandemic: Realities, Parasomnias: Methods, Payment Models and Sleep 2:30 PM for Promoting Sleep, Sex Differences in Challenges and Potential Evidence, and Case Medicine Practice Wakefulness, and Circadian Sleep Regulation, Light Solutions Examples 2:00 PM - 3:45 PM 2:45 PM Health Sensitivity, Cognition, and 2:00 PM - 3:45 PM 2:00 PM - 3:45 PM 2:00 PM - 3:45 PM Insomnia 3:00 PM 2:00 PM - 3:45 PM

3:15 PM

3:30 PM

3:45 PM Break 3:45 PM - 4:00 PM 4:00 PM COV-03: Sleep and Mental O-15: Determinants and R-01: Trainee Challenging I-08: Adolescent Sleep, O-16: Neurobehavioral 4:15 PM Health in Healthcare Outcomes of Sleep and Cases Sleepiness, and Circadian Mechanisms and Outcomes Workers During the Circadian Health Disparities 4:00 PM - 4:45 PM Timing of Sleep/Circadian 4:30 PM COVID-19 Pandemic... 4:00 PM - 4:45 PM 4:00 PM - 4:45 PM Perturbations 4:00 PM - 4:45 PM 4:00 PM - 4:45 PM 4:45 PM Live Networking Events 4:45 PM - 6 :00 PM Assemblies Exhibit Hall | Poster Hall

VIRTUAL SLEEP 2020 GUIDE | 33 | Table of Contents

Basic & Translational Sleep Postgraduate Courses Courses and Circadian Science Track Additional Fees Required Clinical Sleep Science & Practice Track

C-01: Year in Review 2020 The Reasons for Failure of Shahrokh Javaheri, 45 min the SERVE-HF and the Current MD This annual course discusses new perspectives and recent Options to Treat CSA in HFrEF findings in translational science from the past year. Pharmacologic Management of Narcolepsy and Content access through August 1, 2021 45 min Lynn Marie Trotti, MD CME Hours Available: 6.25 Other Disorders of Course Co-Chairs: Romy Hoque, MD and Sigrid Veasey, MD Excessive Sleepiness Raman K. Malhotra, Length Lecture Title Speaker 45 min Medications that Affect Sleep MD 15 min Introduction 45 min Telemedicine is Here Samuel T. Kuna, MD Surgery for the CPAP 45 min Raj C. Dedhia, MD C-03: 2020 State of the Art for Intolerant: Are We There Yet? Clinical Practitioners Hypersomnia: New Meds, 45 min David Plante, MD New Phenotypes This annual course focuses on the best practices for evaluating, diagnosing, and treating the most common sleep disorders in Obesity Hypoventilation: 45 min Atul Malhotra, MD clinical practice. An Update 45 min Sleep and Stroke: An Update Romy Hoque, MD Content access through August 1, 2021 Emerging Technologies CME Hours Available: 6.25 45 min Jacob Collen, MD in Sleep Medicine Course Co-Chairs: Julio Fernandez-Mendoza, PhD and Anne Germain, PhD Putting the Teen Brain 45 min Judy Owens, MD to Sleep Length Lecture Title Speaker 15 min Introduction Insomnia: New Drugs, 45 min Andrew Krystal, MD New Treatment Modalities Insomnia: New Practice Colleen E. Carney, 45 min Parameters and Treatment of PhD Specific Populations An Updated Practical Approach C-02: Trends in Sleep Medicine Bjørn Bjorvatn, 45 min to Circadian Rhythm Sleep- MD, PhD This annual course focuses on topics that are important to the Wake Disorders practice of clinical sleep medicine. New Assessment Methods in Content access through August 1, 2021 45 min Sleep Medicine: Wearables in Kelly Baron, PhD CME Hours Available: 6.25 Clinical Practice Course Co-Chairs: Daniel Barone, MD and Shalini Paruthi, MD Assessment of Daytime Sleepiness and Wakefulness: Length Lecture Title Speaker 45 min Donna Arand, PhD Updated Protocols for the 15 min Introduction MSLT and MWT Good Night, Sleep 45 min Shalini Paruthi, MD Central Hypersomnolence Yves Dauvilliers, Tight: Pediatrics 45 min Disorders: Best Practices and MD, PhD 2020 Legal Update: Stark Law, Management 45 min Telemedicine, and Medicare Daniel Brown, JD Obstructive and Central Sleep Vsevolod Polotsky, Audits are Trending Now 45 min Apnea Syndromes: Current MD, PhD After ‘The Snap’: Integrating and Future Therapies Loretta Colvin, 45 min Telehealth into your Sleep APRN First Line Treatments for RLS: Diego Garcia- 45 min Clinic Iron vs. Medications Borreguero, MD, PhD How to Stay Up Nathaniel Watson, 45 min Current Approaches to Sleep MD Lynn Marie Trotti, to Date in Sleep 45 min in Neurological Disorders and MD RBD: You Should Not Always Daniel A. Barone, Alzheimer’s Disease 45 min Live Out Your Dreams MD

View More Info VIRTUAL SLEEP 2020 GUIDE | 36 | Table of Contents Basic & Translational Sleep Postgraduate Courses and Circadian Science Track Additional Fees Required Clinical Sleep Science & Practice Track

C-04: The Basics of Sleep C-05: PedSleep 2020: Restful Nights, This course provides clinicians and scientists with a background Refreshed Days, and More: Impact of in the fundamental principles and findings that form the core Satisfying Sleep and Lifestyle in Children knowledge of the sleep field. and Adolescents on Health, Well-Being, Content access through August 1, 2021 CME Hours Available: 6.25 and Performance Course Chair: James Shaffery, DPhil This postgraduate course provides a comprehensive evaluation Length Lecture Title Speaker of healthy and disturbed sleep in pediatrics with a specific focus 15 min Introduction on the implications on physical, mental, and cognitive health, well-being, and performance. Normal Human Sleep 45 min Mary Carskadon, PhD Across the Life Cycle Content access through August 1, 2021 Neurobiology, CME Hours Available: 6.25 45 min Neurochemistry, and Thomas Kilduff, PhD Course Co-Chairs: Sanjeev Kothare, MD and Anne Morse, DO Biochemistry of Sleep Length Lecture Title Speaker Sleep Physiology: 5min Introduction 45 min Autonomic Nervous System Ronald Szymusiak, PhD Is Infant and Toddler and Thermoregulation Sleep an Early Predictor of Rebecca M. 45min Sleep Physiology: Neurodevelopment and Spencer, PhD 45 min Endocrinology and Mark Opp, PhD Cognition? Immunology Impact of Poor Pediatric Sleep Circadian System Kenneth Wright, Jr., 45min Shelly Weiss, MD 45 min on Families: What to Recognize and Chronobiology PhD and When to Intervene? Genetics of Sleep in Animals 45 min Paul Shaw, PhD Understanding Relationships and Humans Between Adolescent Sleep Anna Ivanenko, 45min Sleep Deprivation in Disorders, Anxiety, Depression, MD, PhD 45 min Humans: Effects on Namni Goel, PhD Suicide and Substance Abuse Brain and Behavior Sudden Death in Sleep in 55min Sanjeev Kothare, MD Sleep Disorders Childhood: Myth or Reality 45 min Andrew Krystal, MD and Pharmacology Delayed School Start Times: 45min How to Help When it is Not an Judith Owens, MD Option Make Real Life Happen for People with Narcolepsy: 45min Nonpharmacological Anne Morse, DO Behavioral and Lifestyle Choices Impact of Sleep and Circadian Madeleine Grigg- 45min Synchrony on Athletic Damberger, MD Performance in Adolescents Pediatric and Adolescent 45min OSA: Roles of Diet, Exercise Eliot Katz, MD and Appetite

View More Info VIRTUAL SLEEP 2020 GUIDE | 37 | Table of Contents Basic & Translational Sleep Postgraduate Courses and Circadian Science Track Additional Fees Required Clinical Sleep Science & Practice Track

C-06: Behavioral Sleep Medicine: C-07: Consumer Sleep Technology: The Latest Trends and Promising Friend or Foe? Developments Shaping Our Practice This course explores the ever-changing sleep-related in the Future technologies marketed towards patients, with reviews from members of the AASM Clinical and Consumer Sleep Technology This course trains attendees in the delivery of evidence-based Committee. and cutting-edge behavioral sleep medicine assessment and intervention strategies for various patient subgroups, with Content access through August 1, 2021 consideration of future developments. CME Hours Available: 3.25 Course Chair: Seema Khosla, MD Content access through August 1, 2021 CME Hours Available: 6.25 Length Lecture Title Speaker Course Co-Chairs: Jack Edinger, PhD and James Wyatt, PhD 15min Introduction

Length Lecture Title Speaker Consumer Sleep Technology: 45min What is it and What are We Scott Ryals, MD 15min Introduction Supposed to do with it? Consideration of Circadian Sensors and Algorithms: 45min Daniel O’Hearn, MD 45min Rhythms Across Behavioral James Wyatt, PhD What is Inside the Black Box? Sleep Medicine Validation of Consumer CBT-I and Hypnotics: 45min Sleep Technologies: How Cathy Goldstein, MD Strategies for Combining 45min Jack Edinger, PhD Good is Good Enough? Treatments and Aiding in Hypnotic Discontinuation CST from an Industry Perspective: How and Why The Challenge of Treating 45min Jagdeep Bijwadia, MD Julio Fernandez- Sensors are Chosen and How 45min Insomnia Patients with Mendoza, PhD We Approach Validation Objective Short Sleep Duration e-Health Interventions 45min for Insomnia and Related Lee Ritterband, PhD Sleep Disorders Considerations for BSM 45min Jennifer Martin, PhD Interventions in Women Veterans: Special 45min Considerations and BSM Philip Gehrman, PhD Virtual SLEEP provides more access to Treatment Approaches Postgraduate Courses than any SLEEP ever before! Insomnia with Comorbid 45min Jason Ong, PhD Both SLEEP attendees and non-attendees can Obstructive Sleep Apnea purchase up to seven postgraduate courses to learn Using Actigraphy for from until the courses expire August 1st, 2021. 45min the Assessment of Lisa Meltzer, PhD Sleep/Wake Disorders

Buy Now!

View More Info VIRTUAL SLEEP 2020 GUIDE | 38 | Table of Contents INTERESTED IN SUPPORTING THE NEXT GENERATION OF SLEEP AND CIRCADIAN RESEARCHERS?

Looking Back... • Would it have been beneficial to attend more scientific conferences as a trainee? • Did you have a mentor that helped you navigate your path early in your career? • Was applying for your first grant an overwhelming experience? • Do you think an additional $50,000 in research funding would have helped jump-start your career?

The SRS Foundation provides funding for travel grants, mentor programs, grant writing workshops, investigator research awards, and other programs that benefit early-career investigators. Your contribution of $50, $100, $250, $500, or $1,000 will help underwrite these programs to recruit the best and brightest to the sleep and circadian sciences.

All contributions are tax-deductible and will Make your donation today at be recognized through SRSF’s comprehensive https://my.sleepresearchsociety.org/donate recognition program! Make your gift today!

ARE YOU A TOP SLEEP SCORER?

Compare your sleep scoring skills against the AASM Gold Standard Panel and your peers from all around the world. The recently improved Sleep ISR platform provides a 200-epoch record every month, available in both adult and pediatric records, and options for archived records for more practice. Fulfill accreditation standards, identify strengths and opportunities within scoring, and save time with Sleep ISR.

NEW SUBSCRIPTIONS RECEIVE 20% OFF now through September 30th, 2020. Register at isr.aasm.org In Memoriam IndustryINDUSTRY Supported Events SUPPORTED EVENTS

All Industry Supported Events will be featured on-demand on the Virtual SLEEP 2020 Meeting website. Attendees will have access to ISEs August 28, 2020 through August 1, 2021. To access ISEs, hover over the “Sponsored Content” tab on the SLEEP 2020 Meeting website home page.

Adding WAKIX® (pitolisant) Practices for Managing Excessive to Your Clinical Practice Daytime Sleepiness in Patients Speakers: W. Christopher Winter, MD with Narcolepsy and Obstructive and Haramandeep Singh, MD Sleep Apnea Sponsored by Harmony Biosciences, LLC Speakers: Asim Roy, MD and Mask Selector: Patrick Strollo Jr., MD This activity is supported by an independent The Right Fit the First Time educational grant from Jazz Pharmaceuticals, Inc. Speakers: Melissa Ross and Jared Lamb, RPSGT F&P Evora- A new generation of Sponsored by Philips Compact Nasal Mask with World’s first CapFit Headgear Mortality and Hospitalization Speaker: Amanda Blocker in Patients with Heart Failure Sponsored by Fisher & Paykel Healthcare and Sleep Apnea Speaker: Salma Patel, MD, MPH Discovering DAYVIGO: The Science Sponsored by Philips and Data Behind an Orexin Receptor Antagonist for Adult Where do we go From Here? Patients with Insomnia Re-imagine Sleep Labs with Speaker: Alon Avidan, MD, MPH the New Norms Sponsored by: Eisai, Inc. Speakers: Daniel L. Herold, RPSGT and Dennis Hwang, MD Telemedicine & Beyond the AHI Sponsored by Itamar Medical Christoph Schöbel, MD, Jeffrey S. Durmer, MD, PhD, Dennis Hwang, MD Sponsored by: Nox Medical

VIRTUAL SLEEP 2020 GUIDE | 40 | Table of Contents The SLEEP Research Society would like to thank all of our reviewers for their dedication and expertise in advancing SLEEP as The benchmark international journal for sleep and circadian science

Top Reviewers for 2019

Michael Grandner, PhD Michael Chee, MBBS Bei Bei, PhD David Kalmbach, PhD Olivero Bruni, MD Jared Saletin, PhD Sean Drummond, PhD Wendy Troxel, PhD Thomas Penzel, PhD Meredith Wallace, PhD Dale Smith, DO Joshua Wiley, PhD Late Breaking Breaking Abstracts Abstracts

LBA 1 LBA 2 Sleeping While Diving: First Non-Invasive The Unfolded Protein Response Sensor IRE1 is Recording of Sleep in Freely Swimming Marine Required for Sleep Mammals Ewa Strus and Nirinjini Naidoo 1 2 3 3 Kendall-Bar, J.M. ; Pitman, J.K. ; Field, C.L. ; Johnson, S.P. ; Division of Sleep Medicine, Chronobiology and Sleep 4 1 1 Vyssotski, A.L. ; Costa, D.P. ; Williams, T.M. Institute, Perelman School of Medicine, University of 1Ecology and Evolutionary Biology, University of California Pennsylvania Santa Cruz, CA Introduction: The maintenance of protein homeostasis 2Sleep Health MD, Santa Cruz, CA – or proteostasis – is vital to the proper functioning of 3 the organism. One of the effects of sleep deprivation The Marine Mammal Center, Sausalito, CA is an activation of pathways in the cell that regulate 4University of Zurich, Switzerland proteostatic balance, such as the inositol requiring element (IRE1) pathway. IRE1 activation increases chaperone Introduction: Studies examining sleep in marine mammals transcription and the degradation of unwanted mRNA have traditionally relied on either behavioral observation transcripts in response to misfolded protein accumulation exclusively or invasive surgical procedures. Our study and endoplasmic reticulum (ER) stress. Given our recent represents the first non-invasive electroencephalogram findings that proteostasis mechanisms do influence sleep we (EEG) investigating the neurophysiology of sleep in freely examined the role of IRE1 in sleep. swimming elephant seals, using surface-mounted Genuine Grass gold-cup electrodes. Methods: Using pharmacological and genetic approaches, we investigated the effect of manipulating the IRE1pathway Methods: After developing our methods with anesthetized on sleep in Drosophila melanogaster. We used the small animals (N=11), we ruggedized and waterproofed a molecule inhibitors STF to inhibit IRE1 pathway activity in the Neurologger3 (©Evolocus) device to record several days of fly. We also employed the Drosophila GAL4/UAS system to polysomnography, motion, and environmental data for a transgenically knockdown and increase IRE1 pathway activity juvenile elephant seal, on land and diving in a 5-foot pool in Drosophila neurons. under temporary human care. Heart rate artifacts during submersion were removed from polysomnography signals Results: Oral administration of STF, significantly reduced using Independent Components Analysis from the MATLAB nighttime sleep in wildtype flies compared to vehicle EEGLAB toolbox. We identified sleep stage transitions visually controls. Constitutive transgenic expression of IRE1 RNAi and quantified spectral power ( SP) in the delta frequency in neurons also reduced sleep. Furthermore, acute genetic range (0.5-4 Hz) with fast Fourier transform (Hanning expression of IRE1 RNAi in adult neurons also reduced sleep window; resolution 1024) in LabChart훿 (©ADInstruments). in Drosophila. Finally, we demonstrate that knockdown of IRE1 in wake-promoting clock neurons enhances the Results: For the 32.5 hours during which the animal had transcription of the wake-promoting pigment dispersing access to water, the animal spent 72.5% under the water factor (PDF) neuropeptide thus revealing a mechanism holding its breath, in apneas lasting up to 18.5 minutes and through which proteostatic pathways may affect sleep/wake 3.8 minutes on average (SD= 4.3 minutes). It spent 11% behavior. of that time in slow wave sleep across 60 episodes lasting 3.6±2.8 minutes. In water, the seal slept in short cycles tied Conclusions: Together, these results demonstrate that to apneas with a stereotypic pattern from quiet waking (QW: IRE1 is a regulator of sleep and wake that that changes in SP baseline ~38.7uV2 – animal prone at bottom of pool) to IRE1 signaling may be an upstream regulator of sleep- and slow wave sleep (SWS: SP 3.8xQW – animal often supine at clock-relevant neuropeptide signaling. Our results have bottom훿 of pool). It sometimes entered a brief period of very important implications for understanding the cross talk low voltage electrophysiological훿 activity resembling REM between sleep regulation and protein homeostasis in the sleep (REM: SP 0.70xQW – animal often supine at bottom brain. Furthermore, since proteostasis is regulated by both of pool) before returning to quiet or active waking (AW: circadian and homeostatic processes, our findings provide SP>200xQW훿 baseline due to motion artifacts while animal a critical juncture from which to further examine the swims). relationship between sleep and the clock. 훿 Conclusion: This stereotyped pattern closely matches certain drift diving patterns observed in wild, migrating elephant seals. It suggests these animals survive on short (~10 minute) apneic naps over 600 feet below the ocean’s surface for over 7 months at a time. Support: This project received support from the Office of Naval Research Defense University Research Instrumentation Program, National Geographic, and UCSC’s Committee on Research. We declare no competing interests.

VIRTUAL SLEEP 2020 GUIDE | 42 | Table of Contents Late Breaking Abstracts

LBA 3 California, Oakland, CA Sleep Duration and Plasma Metabolites: A 7Department of Medicine, University of Massachusetts Metabolome-Wide Association Study in US Women Medical School, Worcester, MA 8 1 2 2 3,4 California Pacific Medical Center Research Institute, San Josef Fritz , Tianyi Huang , Oana Zeleznik , Kathryn Rexrode , Francisco, CA Christopher M. Depner5, Elizabeth M. Cespedes Feliciano6, Wenjun Li7, Katie L. Stone8, JoAnn E. Manson9, Clary Clish10, 9Department of Medicine, Brigham and Women’s Hospital, Tamar Sofer11, Eva Schernhammer2, Susan Redline9,12, Céline Harvard Medical School, Boston, MA 1,10 Vetter 10Broad Institute of MIT and Harvard, Boston, MA 1 Circadian and Sleep Epidemiology Laboratory, Department 11Division of Sleep and Circadian Disorders, Harvard Medical of Integrative Physiology, University of Colorado Boulder, School, Brigham and Women’s Hospital, Boston, MA Boulder, CO 12 2 Department of Medicine, Beth Israel Deaconess Medical Channing Division of Network Medicine, Department of Center, Boston, MA Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA Introduction: Short and long sleep duration are associated 3 with adverse health outcomes, such as type 2 diabetes, and Division of Preventive Medicine, Department of Medicine, cardiovascular disease. To delineate potential underlying Brigham and Women’s Hospital and Harvard Medical School, biological mechanisms, we examined the association of self- Boston, MA reported short and long sleep duration with human plasma 4Division of Women’s Health, Department of Medicine, metabolites. Brigham and Women’s Hospital, Boston, MA Methods: We analyzed 313 annotated metabolites profiled via 5Sleep and Chronobiology Laboratory, Department of liquid chromatography-mass spectrometry. The discovery data Integrative Physiology, University of Colorado Boulder, consisted of 6,210 women from the Nurses’ Health Study (NHS; Boulder, CO blood collection 1989-1991, mean age 57.0±6.9) and 3,185 6 women from the Nurses’ Health Study II (NHSII; 1996-2000, Division of Research, Kaiser Permanente Northern mean age 44.6±4.5). We tested the replication of findings in an

Approved - Becky Late Breaking Abstracts

independent study of 2,294 women from the Women’s Health Methods: In this phase-3, double-blind, placebo-controlled, Initiative (WHI; 1994-1998, mean age 67.0±6.9). We used linear parallel-group study, 930 patients with insomnia were regression models to cross-sectionally evaluate differences in evenly randomized to daridorexant 25mg, 50mg or placebo, metabolites levels between women with short (<7h), adequate administered nightly for 3-month (M), after a week placebo (7-8h), and long (≥9h) self-reported sleep duration, adjusted baseline and followed by a week placebo run-out. Primary for age, body mass index, physical activity, diet quality, alcohol endpoints were change from baseline in polysomnography consumption, signs of depression, smoking, fasting, and case- sleep parameters wake time after sleep onset (WASO) and control status. Statistical significance was based on P<0.05, latency to persistent sleep (LPS) at 1M and 3M. Secondary false-discovery rate adjusted for both discovery and replication. endpoints were change from baseline in subjective total sleep time (sTST) and daytime functioning using the validated Results: The prevalence of long sleep was low and similar Insomnia Daytime Symptoms and Impacts Questionnaire across cohorts (NHS: 4.4%, NHSII: 5.6%, WHI: 4.6%). Short sleep (IDSIQ) sleepiness score (assessing energy, sleepiness, occurred frequently (NHS: 27.8%, NHSII: 25.8%, WHI: 40.6%). mental and physical tiredness). In the NHS/NHSII, 38 metabolites were significantly associated with short sleep duration. Of these, 8 were replicated in the Results: WASO improvement from baseline (minutes) at 1M WHI: 5 triglycerides, 2 diglycerides, and 1 glycolithocholate. In for placebo, 25mg and 50mg was -6.20, -18.40, and -28.98 long sleep duration analysis, 5 metabolite associations were and at 3M -11.11, -22.97 and -29.41, respectively. For LPS, identified, but none were replicated. improvement from baseline at 1M for placebo, 25mg and 50mg was -19.85, -28.17 and -31.20 and at 3M, -23.13, -30.73 Conclusion: Metabolites associated with short and with long and -34.80, respectively (all p values vs. placebo <0.002). sleep duration did not overlap, suggesting that mechanisms underlying disease-specific associations may be different sTST increase from baseline (minutes) at 1M for between short and long sleepers. The low replication rate placebo, 25mg and 50mg was 21.56, 34.18(p=0.0013), may be explained by marked differences in cohort profiles and 43.62(p<0.0001), and at 3M 37.90, 47.85(p=0.0334), between discovery and replication cohorts and, for long 57.67(p<0.0001), respectively. Daytime functioning improved sleep, by insufficient power. at 1M for placebo, 25mg and 50mg: -2.02, -2.77(p=0.0547) and -3.77(p<0.0001), and at 3M: -3.79, -4.78(p=0.0534) and Support: R21HL145421; Max-Kade-Foundation; NHS/NHSII: -5.70(p=0.0002) for placebo, 25mg, and 50mg, respectively UM1CA186107, P01CA87969, R01CA49449, R01HL034594, p-values vs placebo). R01HL088521, UM1CA176726, R01CA67262, R01HL35464; WHI: HHSN268201300008C, HHSN268201600018C, The most frequent AEs, nasopharyngitis and headache, were HHSN268201600001C, HHSN268201600002C, balanced between arms. Six, 11, and 5 subjects experienced HHSN268201600003C, HHSN268201600004C. somnolence on placebo, 25mg and 50mg daridorexant, respectively. LBA 4 Conclusions: This study showed that daridorexant A Phase 3, Multi-Center, Double- improved objective and subjective sleep parameters, and Blind, Randomized, Placebo- daytime performance using a validated instrument, with an Controlled, Polysomnography Study to Assess acceptable safety profile. Efficacy and Safety of Daridorexant in Adult and Elderly Insomnia Patients Thomas Roth1, Gary Zammit2, Emmanuel Mignot3, Damien Leger4, Claudio Bassetti5, Scott Pain6, Viktoria Hermann6, Dalma Seboek Kinter6 1Division of Sleep Medicine and Research Center, Henry Ford Health System, Detroit, USA 2Clinilabs Inc., New York, USA. 3Stanford Medicine, Center for Narcolepsy, California, USA 4Universite Paris Descartes AP-HP, Paris, France 5Inselspital Universitätsklinik für Neurologie, Bern, Switzerland 6Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland Introduction: Insomnia affects sleep and daytime functioning. Treatment of insomnia should address both; enabling sleep and improving daytime functioning, an outcome lacking in many trials. The first phase-3 trial of daridorexant, a dual orexin receptor antagonist was completed in April 2020 (NCT03545191).

VIRTUAL SLEEP 2020 GUIDE | 44 | Table of Contents Exhibit Hall Floor Plan As of 7/31

VIRTUAL SLEEP 2020 GUIDE | 45 | Table of Contents ExhibitorExhibitors Descriptions As of 7/31/20

AASM Foundation for improvement lie. Users can gain additional insights by reviewing the Gold Standard comparison to see how their Booth 402 results measure up against the experts in the field. Darien, Illinois | foundation.aasm.org (630) 737-9724 Founded in 1998, the American Academy of Sleep Medicine AASM SleepTM Foundation (AASM Foundation) is a not-for-profit 501(c)(3) Booth 430 charitable and scientific organization that was established by Darien, Illinois | sleeptm.com the AASM. Formerly the American Sleep Medicine Foundation (888) 334-6820 (ASMF), the AASM Foundation has invested in the future of AASM SleepTM is a state-of-the-art telemedicine system for sleep medicine by supporting more than 200 awards totaling sleep medicine professionals, accredited sleep centers and over $15 million in funding. Our portfolio includes research durable medical equipment (DME) providers. Expand patient awards for all career stages, community awards and training access to your expertise by integrating secure, web-based awards. video encounters using AASM SleepTM. Choose from two HIPAA-compliant platforms that enable you to provide more AASM Membership efficient, convenient care from a distance.

Booth 400 Darien, Illinois | aasm.org/membership Advanced Brain 630-737-9710 Monitoring, Inc. As the leading voice in the sleep field, the AASM sets Booth 630 standards and promotes excellence in sleep medicine health Carlsbad, California | advancedbrainmonitoring.com care, education, and research. The AASM has a combined (760) 720-0099 ext. 6029 membership of 11,000 accredited member sleep centers Advanced Brain Monitoring is an industry leader in the and individual members, including physicians, scientists, and development of novel diagnostic and treatment technologies other health care professionals. Learn more about our AASM for the sleep medicine field. The Sleep Profiler is a clinically memberships now! validated system for sleep and sleep-disordered breathing in the home or ICU. Night Shift and Apnea Guard deliver therapy AASM Sleep ISR to those suffering from sleep apnea. Booth 429 Darien, Illinois | isr.aasm.org (630) 737-9765 Sleep ISR is the premier resource for the practice and education of scoring sleep studies. Our platform enables both individual and facility users to score new records of 200 epochs every month. Through intelligent reporting options, scorers can identify their strengths and determine where opportunities

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VIRTUAL SLEEP 2020 GUIDE | 46 | Table of Contents Exhibitor Descriptions

the science of human neural systems through modeling and Arbor Pharmaceuticals, analysis with artificial neural systems. One near term practical LLC goal is to bring the science of sleep and memory to improving Booth 619 human mental function.

Atlanta, Georgia | arborpharma.com (678) 334-2420 Bioserenity, Inc. Arbor Pharmaceuticals, headquartered in Atlanta, Georgia, is Booth 618 a specialty pharmaceutical company currently focused on the Atlanta, Georgia | bioserenity.com/en cardiovascular, hospital, neuroscience, and pediatric markets as well as generics through its Wilshire division. Visit www. arborpharma.com or send email inquiries to Brain Vision, LLC [email protected]. Booth 107 Morrisville, North Carolina | brainvision.com (919) 460-2510 Avadel Pharmaceuticals Brain Vision, LLC offers cutting-edge solutions for Booth 413 neurophysiological research. We specialize in the integration of EEG and Polysomnography with fMRI, fNIRS, TMS, tES and Chesterfield, Missouri | avadel.com more. Our sleep solutions are a great fit for research on both (636) 449-1830 infants and adults, and we offer various electrode technologies Avadel Pharmaceuticals is an emerging for use with wired and wireless systems. Our scientific biopharmaceutical company. Avadel’s primary focus is consultant team consists of neuroscientifically driven members the development and potential FDA approval of FT218, our who are eager to address your current experimental needs. Let investigational extended-release sodium oxybate, which has us help you push the edge of what sleep research is possible! completed a Phase 3 clinical trial for the once-nightly treatment of narcolepsy patients suffering from excessive daytime sleepiness (EDS) and cataplexy. Connect with us in Booth #413 Cadwell to learn more about our progress. Industries, Inc. Booth 615 Brain Electrophysiology Kennewick, Washington | cadwell.com (509) 735-6481 Lab (BEL) Company Streamline your sleep diagnostic testing with integrated PSG Booth 110 and HSAT. Initialize, record, score and review both HSAT and Eugene, Oregon | bel.company PSG, performing all of your sleep diagnostics using one efficient software and workflow. Record crystal clear signals, protect (541) 525-9799 your equipment, ensure recording integrity and provide The Brain Electrophysiology Laboratory (BEL), founded in patient convenience during in-lab sleep studies with the Easy the 1980’s on the University of Oregon campus, was later III PSG amplifier and remote input box. Seamlessly integrate moved to EGI (Electrical Geodesics, Inc.) where it served as HSAT in your program with the new generation of ApneaTrak. EGI’s “proving grounds” for research and development. With Cadwell’s entire focus is providing innovative and easy-to-use the Philips acquisition of EGI in 2017, the BEL Company was neurodiagnostic, neuromonitoring, and sleep solutions. formed to continue basic research in human brain function and exploration of new technologies. The BEL mission is to advance

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VIRTUAL SLEEP 2020 GUIDE | 47 | Table of Contents Exhibitor Descriptions

provides. As the U.S. pharmaceutical subsidiary of Tokyo-based CleveMed Eisai Co., Ltd., we have a passionate commitment to patient Booth 118 care that is the driving force behind our efforts to help address Cleveland, Ohio | clevemed.com unmet medical needs. We are a fully integrated pharmaceutical (509) 701-0022 business with discovery, clinical, and marketing capabilities. CleveMed is a fast growing company with a wide range of home Our key areas of focus include oncology and neurology sleep testing services and equipment designed specifically for (dementia-related diseases and neurodegenerative diseases). sleep centers including mail-order HSAT (SleepView Direct), and small high quality sleep monitors (Sapphire PSG™, SleepView®). CleveMed’s goal is to expand the reach of sleep medicine to EnsoData, Inc. improve access and convenience for patients, speed diagnosis Booth 228 for providers, and reduce healthcare costs for payers. Madison, Wisconsin | ensodata.com SleepView is a registered trademark and a service mark, and (608) 509-4704 Sapphire PSG is a trademark of Cleveland Medical Devices, Inc. EnsoData uses Waveform AI technology to perform complex of Cleveland, OH. and time-consuming data interpretation performed by frontline sleep clinicians. EnsoSleep is an AI scoring and analysis tool that Compumedics automates event detection with 90 percent agreement. Clinicians review scored studies in just 15 minutes. This time savings Booth 114 provides new opportunities to grow your testing volume, enhance Charlotte, North Carolina | compumedics.com.au patient care, and improve outcomes and compliance. (877) 717-3975 Compumedics Limited [ASX: CMP] is a medical device company Fisher & Paykel involved in the development, manufacture and commercialization Healthcare of diagnostics technology for the sleep, brain and ultrasonic blood-flow monitoring applications. The company owns US based Booth 522 Neuroscan and Germany based DWL Elektronishe GmbH. In Irvine, California | fphcare.com/us/homecare conjunction with these two subsidiaries, Compumedics has a (949) 453-4000 broad international reach, including the Americas, Australia and Fisher & Paykel Healthcare is a leading designer, Asia Pacific, Europe and the Middle East. manufacturer and marketer of products and systems for use in respiratory care, acute care, surgery and the Eisai, Inc. treatment of obstructive sleep apnea. Our purpose is to improve care and outcomes through inspired and world- Booth 401 leading healthcare solutions. Our highly innovative products Woodcliff Lake, New Jersey |us.eisai.com are sold in more than 120 countries worldwide. (201) 692-1100 At Eisai Inc., human health care (hhc) is our goal. We give our first thoughts to patients and their families and help to increase the benefits health care

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VIRTUAL SLEEP 2020 GUIDE | 48 | Table of Contents Exhibitor Descriptions

General Sleep Corporation scientific core. Located near Basel, Switzerland – a bona fide European biotech hub – Idorsia is specialized in the discovery Booth 115 and development of small molecules to provide innovative Cleveland, Ohio | generalsleep.com therapeutic possibilities. (888) 330-4424 General Sleep Corporation is dedicated to providing Inspire Medical researchers and clinicians with products and services that Systems, Inc. allow them to achieve maximum effectiveness in the study and diagnosis of sleep disorders. Our Zmachine® Synergy product Booth 328 Minneapolis, Minnesota | inspiresleep.com is a highly affordable, 8-channel, Type II or III, home sleep (763) 235-6727 testing system that combines our FDA-cleared EEG-based sleep Inspire Medical Systems, Inc. developed the world’s first fully staging with traditional respiratory & CPAP measures and body implanted neurostimulation device approved by the FDA for position in one compact and easy-to-use device. the treatment of obstructive sleep apnea. The Inspire system uses well established neurostimulation technologies and Harmony Biosciences, LLC incorporates a proprietary algorithm that stimulates key airway Booth 507 muscles based on a patient’s unique breathing patterns. Plymouth Meeting, Pennsylvania | Inspire therapy is designed to reduce OSA severity and improve harmonybiosciences.com quality of life for patients living with this challenging condition. (800) 833-7460 Patients are at the heart of everything we do. Itamar Medical Harmony Biosciences, LLC, is a privately- Booth 313 owned biopharmaceutical company. The company was Atlanta, Georgia | itamar-medical.com established in October 2017 with a vision to provide novel (470) 487-1215 treatment options for people living with rare and orphan Itamar Medical® is a medical technology diseases with an emphasis on central nervous system company focused on the development and disorders, starting with a focus on helping patients who live commercialization of non-invasive medical devices to aid in the with narcolepsy. diagnosis of respiratory sleep disorders. We commercialize a digital healthcare platform to facilitate the continuum of care for effective sleep apnea management with a focus on the core sleep, Idorsia Pharmaceuticals cardiology, and direct to consumer markets. Our prescription Booth 127 WatchPAT family of products, which utilizes the PAT signal, is Allschwil, Switzerland | designed to enable patients suspected to have sleep-related Idorsia.com breathing disorders to easily conduct sleep apnea tests in the +41 58 844 00 00 comfort of their homes in accordance with a physician’s The purpose of Idorsia is to discover, develop and bring more, instructions, as authorized by qualified medical personnel while innovative medicines to patients. We have more ideas, we delivering the treating physicians with comprehensive, accurate see more opportunities and we want to help more patients. and reliable results to aid in the diagnosis of sleep apnea. In order to achieve this, we will develop Idorsia into one of Europe’s leading biopharmaceutical companies, with a strong

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VIRTUAL SLEEP 2020 GUIDE | 49 | Table of Contents Exhibitor Descriptions

of the world’s most challenging diseases. Today, Merck Jazz Pharmaceuticals, Inc. continues to be at the forefront of research to deliver Booth 424 & 625 innovative health solutions and advance the prevention and Palo Alto, California | jazzpharma.com treatment of diseases that threaten people and animals around (650) 496-3777 the world. Jazz Pharmaceuticals plc (Nasdaq: JAZZ) is a global biopharmaceutical company dedicated Metro Health - University of to developing medicines for people with serious diseases — Michigan Health often with limited or no options. We have a diverse portfolio of marketed medicines and novel product candidates, from early- Booth 206 to late-stage development, in key therapeutic areas. Our focus Wyoming, Michigan | metrohealth.net/recruiting is in neuroscience, including sleep medicine and movement (616) 252-5283 disorders, and in oncology, including hematologic and solid Metro Health is dedicated to positively supporting today’s tumors. We actively explore new options for patients including clinicians, while also influencing the physicians of tomorrow. novel compounds, small molecule advancements, biologics and Our commitment to research, technology and medical innovative delivery technologies. education keeps us on the forefront of medicine with the latest capabilities and procedures. We strive to be thought leaders in Med Learning Group the industry and believe that while we can learn from others, others can also learn from us. We invite you to learn more. Booth 207 New York, New York | medlearninggroup.com NightOwl (908) 875-1118 Booth 511 MLG will be showcasing our virtual reality room and Rotselaar, Belgium | nightowl.care providing participants with point of care tools to foster (786) 458-8990 patient education within their own practice. Upon entering the NightOwl® is the latest FDA-cleared HSAT device. Only the cylinder, seated participants are provided 3D-powered glasses size of your fingertip, NightOwl® is based on Peripheral for complete immersion in a 360-degree, 4K VR experience, Arterial Tonometry (PAT) according to the AASM guidelines, exploring the pathogenesis, treatment and perspective of and clinically validated against PSG. The fully-disposable patients affected by DR and AMD. This innovative, educational NightOwl® Mini is packed with sufficient power for 10 nights of initiative provides unparalleled interaction to truly engage with testing, allowing you to finally capture the inter-night variability the information of the AHI as well as continue testing even beyond the initial diagnosis. Our NightOwl® Companion app guides patients Merck & Co., Inc. throughout their testing journey while capturing clinically Booth 222 relevant context. Get your first FREE disposable NightOwl® Kenilworth, New Jersey | merck.com Mini by visiting signup.nightowl.care/SLEEP2020. NightOwl® is (800) 444-2080 brought to you by Ectosense (Belgium). For more than a century, Merck has been inventing for life, bringing forward medicines and vaccines for many

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Nonin Medical, Inc. Advances is an online-only, fully Open Access publication of the SRS; the journal is new in 2020. Explore both journals via Booth 108 their websites below: https://academic.oup.com/sleep https:// Plymouth, Minnesota | nonin.com academic.oup.com/sleepadvances (763) 577-2633 Since 1986, Nonin Medical has developed reliable technologies and manufactured durable noninvasive patient monitoring Pear Therapeutics devices for healthcare professionals and consumers. Nonin Booth 611 pulse oximeters, cerebral and tissue oximeters, capnographs, Boston, Massachusetts | sensors, and software deliver dependable performance peartherapeutics.com day after day—even in challenging environments. Nonin (617) 932-7108 solutions are used extensively in sleep apnea screening and Pear Therapeutics is a leader in prescription digital polysomnography. therapeutics (PDT). We aim to redefine medicine by delivering clinically validated software-based therapeutics to provide Nox Medical better outcomes for patients and tracking tools for clinicians. Our product SomrystTM is the first FDA market authorized PDT Booth 121 intended to treat patients ages 22 years of age and older with Reykjavik, Iceland | noxmedical.com chronic insomnia. (354) 570-7170. Nox Medical is a global leader in the sleep diagnostic technology space. The company provides sleep Philips specialists with patient-friendly diagnostic devices and robust, Booth 301 reliable data collection. With easy-to-use medical device Murrysville, Massachusetts technology, Nox Medical eliminates common diagnostic pain Philips is a leading health technology company focused points by prioritizing patient comfort and reliability of results, on improving people’s health and enabling better allowing providers to better assess, diagnose and treat the outcomes across the health continuum from healthy living and entire range of sleep health issues. prevention, to diagnosis, treatment and home care, by leveraging advanced technology and deep clinical and consumer insights to Oxford University Press deliver integrated solutions. Headquartered in the Netherlands, Philips is a leader in diagnostic imaging, image-guided therapy, Booth 607 patient monitoring and health informatics, as well as in consumer New York, New York | academic.oup.com/journals health and home care. (919) 677-0977 ext. 5161 Oxford University Press publishes some of the most respected, prestigious books and journals in the world, including SLEEP® and SLEEP Advances. SLEEP® is the benchmark international journal for sleep and circadian science and is the official publication of the Sleep Research Society (SRS). SLEEP

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VIRTUAL SLEEP 2020 GUIDE | 51 | Table of Contents Exhibitor Descriptions

patients to machines. Through innovative design and quality REMfresh manufacturing, we provide superior products and the highest Booth 214 level of customer service in the industry, without wavering in Boca Raton, Florida | our commitment to fair pricing. remfresh.com (561) 301-2025 Physician’s Seal, the innovator of REMfresh®, was Sizewise founded in 2013 by former pharmaceutical executives Booth 528 who wanted to design, develop and deliver non Lenexa, Kansas | sizewise.com/sleep2020 prescription sleep aids to help consumers sleep and live better. (800) 814-9389 We have developed our products with patented delivery The Instant Comfort® Sleep Lab Bed provides a unique technologies to help ensure those ingredients work smarter and advancement for your sleep center—pairing an air-adjustable better, without any compromise to our customers. Unlike other number bed with a medical-grade top cover. Most sleep lab melatonin products, REMfresh’s patented technology releases beds utilize quilted fabric top covers that absorb fluids, odors, melatonin continuously for up to 7 hours, mimicking the body’s and colors. The Instant Comfort® Sleep Lab Bed is designed natural release of melatonin. This may help you fall asleep faster, with an extreme polycarbonate fabric, which resists cleaning stay asleep longer, and experience better quality sleep. chemicals—supporting CDC cleaning guidelines and higher level of infection control and prevention. Respicardia Booth 101 Sleep Research Society Minnetonka, Minnesota | respicardia.com Foundation (952) 540-4470 Booth 411 Respicardia® is a leader in innovative technologies Darien, IL | sleepresearchsociety.org/foundation that address the unmet needs in respiratory and (630) 737-9702 cardiovascular disease with safe and effective therapies. The Sleep Research Society Foundation is committed to Founded in 2006 and headquartered near Minneapolis, the growth and development of the field of sleep and Minnesota, Respicardia is dedicated to improving patient circadian research through education and research funding outcomes, quality of life and overall cardiovascular health via opportunities. novel transvenous neurostimulation therapies.

Rhythmlink Booth 124 Columbia, South Carolina | rhythmlink.com (952) 540-4470 Rhythmlink® International, LLC wants to enhance patient care by transforming the medical device technology that links

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VIRTUAL SLEEP 2020 GUIDE | 52 | Table of Contents Exhibitor Descriptions

SLEEPLAB.COM / PAP SNUGZ Mask Liners ASSESSMENTS Booth 100 Booth 437 Calverton, Maryland | sleepsnugz.com Toronto, Ontario | sleeplab.com (240) 790-0598 (647) 725-7756 Introducing Snugz, a cool new partner in the bedroom. Snugz Mask Liners for CPAP Machines are machine washable, Sleeplab.com is a preeminent tele-sleep support services one-size-fits-most liners designed for either full-face or nasal provider utilizing advanced methodology and cutting-edge CPAP masks. They help reduce noisy leaks, prevent redness technology to facilitate virtual patient care in an efficient and and irritation, and feel great against your skin. If you suffer cost effective manner while adhering to all applicable medical from sleep apnea, you’re going to love them. standards. During the COVID-19 pandemic our positive airway pressure assessment program offers enhanced safety Somnoware Healthcare Systems for routine PAP follow up, identification and treatment of Booth 601 therapeutic problems and monitoring out of lab auto PAP Santa Clara, California | somnoware.com titration. Prior to their timely telehealth visit, the patient and 408-758-2259 physician download the assessment report correlating data Somnoware is an end-to-end sleep health management download findings with the corresponding clinical history platform that unifies data from all in-lab and HST diagnostic reflecting compliance and response to therapy. devices, EMR applications, and CPAP machines to accelerate diagnosis of OSA and improve patient treatment outcomes. SleepSense Our cloud-based solution enables care providers to estimate population risk, automate diagnosis workflow, better manage Booth 514 chronic care, and optimize patient outcomes. Our customer Elgin, Illinois | sleepsense.com base includes leading health systems, independent sleep (888) 757-7367 centers, and sleep services companies. For over 25 years SLP has been introducing innovative and high quality sleep diagnostic sensors into sleep markets worldwide. The SleepSense line of sleep diagnostic sensors is designed SRS to offer more accurate signal readings, higher durability and Booth 412 better patient compliance. View our full product line at www. Darien, Illinois | sleepresearchsociety.org SleepSense.com which includes many Reusable or Disposable Sleep Research Society membership has grown to all levels options for nearly all PSG systems and several HST systems. and disciplines in sleep and circadian science across the globe. Membership includes mentoring opportunities, additional Sleepstation resources, and advocacy. Further your career in the field of Booth 614 sleep medicine through SRS. Newcastle upon Tyne, England | sleepstation.org.uk

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VIRTUAL SLEEP 2020 GUIDE | 53 | Table of Contents Exhibitor Descriptions

Takeda Pharmaceuticals Virtuox, Inc. Intl., Co. Booth 501 Booth 335 Coral Springs, Florida | virtuox.net Cambridge, Massachusetts | takeda.com Takeda has been driven by the unmet needs of patients, since our founding in 1781. Our mission is to bring innovative World Sleep Society medicines to individuals with diseases for whom there are limited or no treatments available, including those with sleep- Booth 436 Rochester, Minnesota | wake disorders. worldsleepsociety.org (507) 316-0084 UCLA Health World Sleep Society (WSS), representing both individual Booth 438 sleep professionals and sleep societies operates programs of Los Angeles, California | uclahealthcareers.org education, awareness, and member services. The World Sleep Society’s mission is to advance sleep health worldwide. (310) 267-3292 UCLA Health defines greatness by the quality of the patient experience we are able to deliver. Each and every time. To every single patient. If that’s where your ambitions lie, UCLA is where you belong. We offer unequaled challenges and opportunities to further your education, training and career.

Vanda Pharmaceuticals, Inc. Booth 136 Washington, DC | vandapharma.com

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VIRTUAL SLEEP 2020 GUIDE | 54 | Table of Contents Learn how BELSOMRA could help your patients Visit MerckConnect.com/belsomra for more information

VIRTUAL SLEEP 2020 GUIDE | 55 | Table of Contents Join us (virtually, at least) @ SLEEP 2020

Be one of the first to see the clinical Visit the Idorsia virtual booth data from our pivotal Phase 3 trial to find out more in our late-breaking session! Get to know us at www.idorsia.com

Expert opinions presented by: Alon Y. Avidan, MD, MPH Professor, UCLA Department of Neurology Director, UCLA Sleep Disorders Center David Geffen School of Medicine at UCLA

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INDICATION DAYVIGO (lemborexant) is an orexin receptor antagonist indicated for the treatment of adult patients with insomnia, characterized by difficulties with sleep onset and/or sleep maintenance. IMPORTANT SAFETY INFORMATION food, making phone calls, having sex), have been was somnolence (10% for DAYVIGO 10 mg, 7% for reported to occur with the use of hypnotics such DAYVIGO 5 mg, 1% for placebo). CONTRAINDICATIONS as DAYVIGO. Events can occur in hypnotic-naïve DRUG INTERACTIONS • DAYVIGO is contraindicated in patients with and hypnotic-experienced persons. Patients narcolepsy. usually do not remember these events. Complex • CYP3A Inhibitors: The maximum recommended dose of DAYVIGO is 5 mg no more than once per WARNINGS AND PRECAUTIONS sleep behaviors may occur following the first or any subsequent use of DAYVIGO, with or without night when co-administered with weak CYP3A • Central Nervous System (CNS) Depressant Effects inhibitors. Avoid concomitant use of DAYVIGO with and Daytime Impairment: the concomitant use of alcohol and other CNS depressants. Discontinue DAYVIGO immediately if strong or moderate CYP3A inhibitors. DAYVIGO can impair daytime wakefulness. CNS a patient experiences a complex sleep behavior. • CYP3A Inducers: Avoid concomitant use of depressant effects may persist in some patients DAYVIGO with moderate or strong CYP3A inducers. up to several days after discontinuing DAYVIGO. • Patients with Compromised Respiratory Function: Prescribers should advise patients about the The effect of DAYVIGO on respiratory function USE IN SPECIFIC POPULATIONS potential for next-day somnolence. should be considered for patients with • Pregnancy and Lactation: There is a pregnancy compromised respiratory function. DAYVIGO has exposure registry that monitors pregnancy Driving ability was impaired in some subjects taking outcomes in women who are exposed to DAYVIGO DAYVIGO 10 mg. Risk of daytime impairment not been studied in patients with moderate to severe obstructive sleep apnea (OSA) or chronic during pregnancy. Healthcare providers are is increased if DAYVIGO is taken with less than encouraged to register patients in the DAYVIGO a full night of sleep remaining or at a higher obstructive pulmonary disease (COPD). • Worsening of Depression/Suicidal Ideation: pregnancy registry by calling 1-888-274-2378. than recommended dose. If taken in these There are no available data on DAYVIGO use in circumstances, patients should not drive or engage Incidence of suicidal ideation or suicidal behavior, pregnant women to evaluate for a drug-associated in activities requiring mental alertness. as assessed by questionnaire, was higher in risk of major birth defects, miscarriage, or adverse Use with other classes of CNS depressants (e.g., patients receiving DAYVIGO than placebo (0.3% maternal or fetal outcomes. benzodiazepines, opioids, tricyclic antidepressants, for DAYVIGO 10 mg, 0.4% for DAYVIGO 5 mg, and 0.2% for placebo). There are no data on the presence of lemborexant alcohol) increases the risk of CNS depression, in human milk, the effects on the breastfed infant, which can cause daytime impairment. Dosage In primarily depressed patients treated with or the effects on milk production. Infants exposed adjustments of DAYVIGO and concomitant CNS hypnotics, worsening of depression and suicidal to DAYVIGO through breastmilk should be depressants may be necessary when administered thoughts and actions (including completed monitored for excess sedation. together. Use of DAYVIGO with other insomnia suicides) have been reported. Suicidal tendencies drugs is not recommended. Patients should be may be present in such patients and protective • Geriatric Use: Exercise caution when using doses advised not to consume alcohol in combination measures may be required. Intentional overdose is higher than 5 mg in patients ≥65 years old. with DAYVIGO. more common in this group of patients; therefore, • Renal Impairment: Patients with severe renal Because DAYVIGO can cause drowsiness, patients, the lowest number of tablets that is feasible should impairment may experience an increased risk particularly the elderly, are at a higher risk of falls. be prescribed at any one time. of somnolence. • Sleep Paralysis, Hypnagogic/Hypnopompic The emergence of any new behavioral sign • Hepatic Impairment: The maximum recommended Hallucinations, and Cataplexy-Like Symptoms: or symptom of concern requires careful and dose of DAYVIGO is 5 mg in patients with moderate hepatic impairment. DAYVIGO is not recommended Sleep paralysis, an inability to move or speak for up immediate evaluation. • Need to Evaluate for Comorbid Diagnoses: in patients with severe hepatic impairment. Patients to several minutes during sleep-wake transitions, with mild hepatic impairment may experience an hypnagogic/hypnopompic hallucinations, including Treatment of insomnia should be initiated only increased risk of somnolence. vivid and disturbing perceptions can occur with after careful evaluation of the patient. Reevaluate DAYVIGO. Prescribers should explain these events for comorbid conditions if insomnia persists or DRUG ABUSE AND DEPENDENCE to patients. worsens after 7 to 10 days of treatment. Worsening • DAYVIGO is a Schedule IV-controlled substance. Symptoms similar to mild cataplexy can occur with of insomnia or the emergence of new cognitive or • Because individuals with a history of abuse or DAYVIGO and can include periods of leg weakness behavioral abnormalities may be the result of an addiction to alcohol or other drugs may be at lasting from seconds to a few minutes, can occur unrecognized underlying psychiatric or medical increased risk for abuse and addiction to DAYVIGO, either at night or during the day, and may not be disorder and can emerge during the course of follow such patients carefully. associated with identified triggering event (e.g., treatment with sleep-promoting drugs such laughter or surprise). as DAYVIGO. • Complex Sleep Behaviors: ADVERSE REACTIONS Reference: DAYVIGO (lemborexant) [Prescribing Information]. Woodcliff Lake, NJ: Eisai Inc. Complex sleep behaviors, including sleep-walking, • The most common adverse reaction (reported sleep-driving, and engaging in other activities in 5% of patients treated with DAYVIGO and at For more information about DAYVIGO, please see the full while not fully awake (e.g., preparing and eating least twice the rate of placebo) with DAYVIGO Prescribing Information at the virtual booth.

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DAYVIGO™ is a trademark of Eisai R&D Management Co., Ltd and is licensed to Eisai Inc., Woodcliff Lake, NJ 07677 DAYV-US2412 07/2020 © 2020 Eisai Inc. All rights reserved. Satellite Symposium Telemedicine & Beyond the AHI

At the Virtual SLEEP meeting, Nox Medical will host a satellite symposium titled “Telemedicine & Beyond the AHI” on some of the main challenges in today’s sleep medicine. The discussions will be made available by three excellent speakers:

• Jeffrey S. Durmer, MD, PhD • Prof.Dr. Christoph Schöbel, MD • Dennis Hwang, MD

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VIRTUAL SLEEP 2020 GUIDE | 59 | Table of Contents