9ęඈඋ1࣏ۘऺ: Chinese Journal of Tissue Engineering Research www.CRTER.org

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 bɃş ᾕΞæ ᰹ ̢ ⚭†· ᾱξš ɏ͏φ Ƞęȭ ( LşďijƵƏ̷½K̂ZàʹƜď 072750Z ̵ãî͸ijƵȰ   ij½K̵ɣʘƲDZƍʑǪʱΚď 830000Z Ȫ̵ďƏ̷½KƢ˱àȪ̵ď 123000Z ȧĂî͸ȰijQž½K°˒ď 201508)+ DOI:10.3969/j.issn.2095-4344.0105 ORCID: 0000-0001-7137-389X(bɃş)

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Prevalence of knee osteoarthritis in the middle-aged and elderly in China: a Meta-analysis

  
Tie Xiao-jia , Zheng Ru-geng , Zhao Meng , Han Ya-jun , Guo Hong-liang , Wang Zhi-zhou , Ma Guo-ju
 ( Baoding Second Central Hospital, Zhuozhou 072750, Hebei Province, China; the Second Affiliated Hospital of  Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China; Fuxin Central Hospital,  Fuxin 123000, Liaoning Province, China; Jinshan Hospital of Fudan University, Shanghai 201508, China)

Abstract BACKGROUND: Investigation on epidemiologic features of knee osteoarthritis in many areas of China has been much reported. However, multicenter studies with large samples have been rarely reported. The published papers cannot give a good description about the epidemiologic features of knee osteoarthritis. OBJECTIVE: To evaluate the epidemiologic features of knee osteoarthritis in the patients aged over 40 years in China.

METHODS: Meta-analysis was used to evaluate the data extracted from papers published 2001
2016 on the Tie Xiao-jia, Master, Baoding epidemiology of knee osteoarthritis in the middle-aged and elderly in China. The prevalence rate of knee Second Central Hospital, osteoarthritis in the patients over 40 years of age was summarized, with every 10 years as group, and then Zhuozhou 072750, Hebei analyzed on Stata 12.0 software. Province, China RESULTS AND CONCLUSION: Twenty-six articles were included, involving 42 199 people aged more than 40 years old. The total prevalence rate of knee osteoarthritis at the age above 40 years old in China was 17.0% Corresponding author: (95%CI: 16.7%
17.4%), the prevalence rate was 12.3% in male and 22.2% in female (P < 0.05). Noticeably, the Ma Guo-ju, Chief physician, prevalence rate increased with age. The total prevalence rate in northern China was 16.1% (95%CI: Baoding Second Central 15.6%
16.6%), 12.2% in male and 21.4% in female; the total prevalence in southern China was 18.0% (95%CI: Hospital, Zhuozhou 072750, 17.5%
18.5%), 12.3% in male and 23.1% in female. There was no significant difference in the prevalence rate Hebei Province, China

650 তේǻ:2095-4344(2018)04-00650-07 Tie XJ, Zheng RG, Zhao M, Han YJ, Guo HL, Wang ZZ, Ma GJ. Prevalence of knee osteoarthritis in the middle-aged and elderly in China: a Meta-analysis. Zhongguo Zuzhi Gongcheng Yanjiu. 2018;22(4):650-656.DOI:10.3969/j.issn.2095-4344. 0105 between northern and southern China (P > 0.05). The total prevalence rate in rural China was 23.6% (95%CI: 16.7%
30.4%), with 15.4% in male and 28.1% in female; and the total prevalence in urban China was 20.0% (95%CI: 16.2%
23.9%), with 13.7% in male and 24.3% in female. There was no significant difference in the prevalence rate between rural and urban China (P > 0.05). These results suggest that knee osteoarthritis in China is a common disease, characterized by increased prevalence with age, relatively significant difference between male and female, but no difference between northern and southern China as well as between rural and urban China. It is of great significance to timely propagate and perform interventional strategies for prevention and treatment of knee osteoarthritis in China. Subject headings: China; Knee Joint; Osteoarthritis; Meta-Analysis; Tissue Engineering

0 šᣄ Introduction ҉ɋǎ͢95%าǍľⒸ(CI)4₋Ϭḳâhomogeneity test ၡ͟ᅆɜ͟ᅆ̺«P࢑„ᢅՈ໅À¦҂҉ ₑƽ ẟᜐŎᯬɳ̼ɀ ÑP > 0.1ʐI2 < 50%&̼ɀˈβ Ȑr ˑ؄໅À¦ՈϣϏᯬₓ Ȑrඝ˯້ʐࠂĆrǡ̝ₑՈ ƍᱷÑZǝârᜬŠȌÂάàₓȐᯬ ūϬĖǎάà ᯣĩ[1] ń๒ę«ȰႸ50ʵÑZϻɳ͍·¬࿁ŸՈৰx µƧẟᜐMeta Ȍ Ǒ7ᜬŠƌńŎᯬɳ ₋Ϭ╓ƶά ü௤[2]4╓؄ęͱ¦ǧ໅ܸĚaᱏŠº ẝP⒲L’╓ àµƧ4̓ 7ॅº4ęŌǻẁⓘ ȈŌľʨȅ3ɳʟǎ¦ØϣϏL ̻Ո]Ȑ ၡ͟ᅆɜ͟ᅆ̺˯҉ɋ’]Ȑ4ẕÀǡęɎ 2඗ȘResults ෾;ṇƿ5Ոၡ͟ᅆɜ͟ᅆ̺˯҉źΡՈϔǒ &Ǹত 2.1 ɻˬϗƔBˌ ̼͝௦46 835ઋDz ඓਟọȒ͝൷ ₋ϬMeta ȌՈ5ͩ වȌ Ȍ>ǕᜬՈ͟zę໅À ͑26ઋ[4-29] ȴǚ40ʵÑZ¦๨ʳƨʇₓ42 199¦ ͢ȴ ၡ͟ᅆɜ͟ᅆ̺Ոּ͟Dz rᢧęͱၡ͟ᅆɜ͟ᅆ̺ ǚϻɳ16 531¦ ȴǚΏɳ18 657¦4Dza֚rę11¦ Ρ &ၡ͟ᅆ҂҉Ոeƛ8⓶ȴƇ࢕ƚƉǒ4 ׅ32ָṚNՈ໅À¦4DzȖƨĽǍᢅᜬ14̑҉˯ 2.2 ˃ ˿͇͉Dȁĝ)̼ ]Ȑɳ/3Àܸɉϟǎ඗Ș 1 ᰈʐ5ͩ Data and methods ᢅᜬ2440ʵÑZ¦๨ၡ͟ᅆɜ͟ᅆ̺ʇĿ˯҉ɋ& 1.1 Éα ̼௦ϔǒßĉŐPubMed3Medline3Cochrane 17.0%(95%CI16.7%
17.4%) ͢ϻɳ12.3%(95% CI Library3ęϣĭĿƚDzϔǒß(CBM)3මêǍʻᰈļி 11.8%
12.8%) Ώɳ22.2%(95%CI21.6%
22.8%) ϻ ඣ3ęƛ͔ϔǒß(CNKI)3W5ϔǒß4Ǫ̲ʵǒ> Ώ7Ⓒɨṇ:Ŏƅºጛɳ͛5(P < 0.05) ᢅĚ134 ൷͑DzՈdž໇DzẟᜐDzềᳮ4 ºɳ/ȭɨᢆȓdzᢅ໅Àϻ3Ώɳ5Àܸඈၡ͟ ᆵ̼௦᪑Knee Osteoarthritis OA prevalence ᅆɜ͟ᅆ̺˯҉ɋţᜬɴ&Ώɳʌzϻɳ4º]ȐÀܸ China̼௦᪑ၡ ɜ͟ᅆ̺ O ᫇ɡʐϕᜐ҉ ඈȭɨᢆȓdzᢅ ϻɳǎΏɳၡ͟ᅆɜ͟ᅆ̺˯҉ɋţ ƚ4Κ▊2001Ⴗ2016À͟zę¦๨ၡ͟ᅆɜ͟ᅆ̺˯҉ ╓Àܸʺ¤໐ʺʌ ϻΏɳţɌɴ70ʵÑȒÀܸɉ˯҉ ΡՈDz4 ɋʺ⑃Šº¤ȷ4ϻɳ40
69ʵÀܸɉ˯҉ɋʺ⑃ּȭ¿෗̑ 1.2 ǒƽ Ώɳº40
49ʵÀܸɉႷ50
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59ʵÀܸɉႷ60
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16.6%) ͢  ϻ ɳ ˯ ҉ ɋ & 1.2.2 Ƕ┨ʃβ ϔǒƅŠº⏝᪳3ϔǒ]ǀϘz]± 12.2%(95%CI11.5%
12.9%) Ώɳ&21.4%(95%CI ϖ\ͩ-ϬՈDz ¦๨ọō&Ŀ┦ɑăĿ̼¦๨Ñǎ 20.6%
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18.5%) ͢ϻɳ˯҉ɋ&12.3%(95%CI11.6%
 Dz4 13.0%) Ώɳ&23.1%(95%CI22.2%
23.9%)4ńϻɳ Dzਟọ ỞẋⓉᪿ2001Ⴗ2016ÀǕᜬՈּ͟ ¦๨3Ώɳ¦๨ǎʇĿ¦๨ţɌɴśě57Ⓒ˯҉ɋɨ 1.2.3 DzՈʼᡅẟᜐ!ਟ ͹ȭ!ਟՈDzⓉᪿ͔ẟᜐxƵਟ ṇ:Ŏ\ºጛɳ͛5(P > 0.05)4 ọ ϢȒŭ+൷͑ǎǶ┨ʃβX┨]ȌʸՈDz4Ǹẋ࣏ 2.4 ˺à dď͉Dȁĝ)̼ ΈǍǎǪNⒸၡ͟ᅆɜ͟ ϵৰ3¦ ᅆ̺˯҉ɋ̑Ρᢅᜬ4ǎĚ64ϵ2ȑۘऺ້ưএǀt ȭƅ]Ȑ͛ᢅՈDz ǕʴΟǎ«ȪơϬ4 40ʵÑZ¦๨ၡ͟ᅆɜ͟ᅆ̺ʇĿ˯҉ɋńΈǍŌľ 1.2.4 Dzᯬₓ᪈Ĝ ₋ϬSTROBĚŠ⍌ȭ¾)☦ &23.6%(95%CI16.7%
30.4%) ͢ϻɳ˯҉ɋ& (ĉŐLֲʐʼᡅ3Qᣄ35 15.4%(95%CI9.0%
21.7%) Ώɳ&28.1%(95%CI ऺՈ൷͑ʃβẟᜐᯬₓ᪈ۘ  ͝ᩥ22ǝֲ)[3]4 16.1%
40.1%)4ǪNŌľʇĿ˯҉ɋ&20.0%(95%CI 3඗Șʐᩬ᩾5ᾬͩ 1.2.5 ඣᩥƚ Ȍ ϔǒ̠ˊ₋ϬStata 12.0ǀt ᩥਜ਼˯ 16.2%
23.9%) ͢ϻɳ˯҉ɋ&13.7%(95%CI9.9%

P.O. Box 10002, Shenyang 110180 www.CRTER.org 651 bɃş ᾕΞæ ᰹̢ ⚭†· ᾱξš ɏ͏φ Ƞęȭ. ę໅À¦ၡ͟ᅆɜ͟ᅆ̺˯҉ɋՈ Meta Ȍ[J]. ęඈඋ1࣏ۘऺ 2018 22(4):650-656.DOI:10.3969/j.issn.2095-4344.0105

Ě 1 ęϻɳ໅À¦๨ၡ ͟ᅆɜ͟ᅆ̺]ȐÀܸ˯҉ɋ Figure 1 The prevalence

rate of knee osteoarthritis in the male middle-aged and elderly in China in different age groups Ěͼ40 ʵÑZϻɳ¦๨ၡ͟ ᅆɜ͟ᅆ̺˯҉ɋ& 12.3%4

Ě 2 ęΏɳ໅À¦๨ၡ ͟ᅆɜ͟ᅆ̺]ȐÀܸ˯҉ɋ Figure 2 The prevalence

rate of knee osteoarthritis in the female middle-aged and elderly in China in different age groups

Ěͼ40 ʵÑZΏɳ¦๨ၡ͟ ᅆɜ͟ᅆ̺˯҉ɋ& 22.2%4

Ě 3 ę໅À¦๨(ϻɳ+ Ώɳ)ၡ͟ᅆɜ͟ᅆ̺]ȐÀ ܸ˯҉ɋ Figure 3 The prevalence rate of knee osteoarthritis in

the middle-aged and elderly in China in different age groups Ěͼ40 ʵÑZ¦๨ၡ͟ᅆɜ ͟ᅆ̺ʇĿ˯҉ɋ& 17.0% ϻΏ7Ⓒɨṇ:Ŏƅºጛɳ͛ 5 Ώɳʌzϻɳ(P < 0.05)4

652 ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH g Tie XJ, Zheng RG, Zhao M, Han YJ, Guo HL, Wang ZZ, Ma GJ. Prevalence of knee osteoarthritis in the middle-aged and elderly in China: a Meta-analysis. Zhongguo Zuzhi Gongcheng Yanjiu. 2018;22(4):650-656.DOI:10.3969/j.issn.2095-4344. 0105

Ě 4 ę໅À¦๨ၡ͟ᅆɜ ͟ᅆ̺ě5˯҉ɋ Figure 4 The prevalence rate

of knee osteoarthritis in the middle-aged and elderly in northern China Ěͼ40 ʵÑZ¦๨ၡ͟ᅆɜ͟ ᅆ ̺ ʇ Ŀ ě 5 Ō ľ ˯ ҉ ɋ &

16.1%4

Ě 5 ę໅À¦๨ၡ͟ᅆɜ ͟ᅆ̺ś5˯҉ɋ Figure 5 The prevalence rate of knee osteoarthritis in the middle-aged and elderly in

southern China Ěͼ40 ʵÑZ¦๨ၡ͟ᅆɜ͟ ᅆ ̺ ś 5 Ō ľ ʇ Ŀ ˯ ҉ ɋ & 18.0%4

Ě 6 ę໅À¦๨ၡ͟ᅆɜ ͟ᅆ̺ΈǍǎǪN˯҉ɋ Figure 6 The prevalence rate of knee osteoarthritis in the

middle-aged and elderly in rural and urban China ĚͼʇĿ¦๨ΈǍǎǪN7 Ⓒၡ͟ᅆɜ͟ᅆ̺˯҉ɋɨṇ: Ŏ\ºጛɳ͛5(P > 0.05)4

P.O. Box 10002, Shenyang 110180 www.CRTER.org 653 bɃş ᾕΞæ ᰹̢ ⚭†· ᾱξš ɏ͏φ Ƞęȭ. ę໅À¦ၡ͟ᅆɜ͟ᅆ̺˯҉ɋՈ Meta Ȍ[J]. ęඈඋ1࣏ۘऺ 2018 22(4):650-656.DOI:10.3969/j.issn.2095-4344.0105

ᜬ 1 ൷͑DzȖƨǍʻ Table 1 Basic information of the included literatures

ৰP Ǖᜬ ᫇ɡŌľ Àܸ ʇʳ ġʳ ᪎)ʃβ  ৰP Ǖᜬ ᫇ɡŌľ Àܸ ʇʳ ġʳ ᪎)ʃβ ň້ rⒸ (ʵ) ƨₓ 5ͩ  ň້ rⒸ (ʵ) ƨₓ 5ͩ


 ᆓ⓷  2010 ËׅË*N > 40 1 339 M Œ Ŀ ƚĆ ʃβ  ᇇ˴  2010 Z#Nȏࠂľ > 60 1 002 S  Œ Ŀ ƚ Ć ʃ β (2003) (2007)

 (Ŭņ,  2007 ࡓņׅ͝*N > 60 500 C ACR(1995) ƍ൦  2013 ʥNɃŌľ > 50 1 986 S ACR(1995

  (ɏċ  2007 ┙ᡃׅᡃƽN > 40 1 000 M ůϣᾬě˜Ŀ┦᫂  -Ïċ  2014 ŏNปĂľ > 50 1 000 C ACR(1995 Lඈʃβ

 õǺ  2010 ě˜N > 50 291 S ACR(1995) Ⴋ⑃#  2006 ʥᡃׅ͆ƣNࠂľ > 16 3 915 C ACR

 śׅẮÒ* > 50 554 C Œ Ŀ ƚĆ ʃβ  ƿ௤ᄷ  2013 ͇ěׅ̔ʥN > 50 1 068 M  Œ Ŀ ƚ Ć ʃ β{ 2013  ݍ˳̔ (2007) (2003)

 ȓȕ.  2013 Ë*Nᅵ῁ľ > 40 963  Framingham ɜ͟ ƿ█ᆵ  2011 ě˜NǴľ⑃ṟ > 50 1 507 M ůϣᾬě˜Ŀ┦᫂ ᅆۘऺʃβ ã Lඈʃβ
 
 Ŭęᄳ  2011 ͇śׅ5Ǫǃ > 50 505 C ůϣᾬě˜Ŀ┦᫂  Ǥ☝  2010 ÷)ׅ(<ʥ3▉ƽ3> 40 843 M ůϣᾬě˜Ŀ┦᫂ Lඈʃβ ඹ⓷) Lඈʃβ

 (M ACR(1995 534 5 40 < ڷ) ׅ(ˌɈ > 40 1 196 M ůϣᾬě˜Ŀ┦᫂  ᑟÒ}  2015 ę͙̓ᜐΣľ˳ݍڅ ሧǬϣ  2010 ƔN3ཋļǃ) Lඈʃβ ǪÐ3ˌɈƔ3Z#3 Ë*3t῁3ᡃƽ)
 
 Ăśׅ(˧⓷N3 > 40 392 M Œ Ŀ ƚĆ ʃβ  2Ṧ  2013 Z#NⒹᜐľ > 60 502 S Altman Öʐ΢ 2014  ݍȃ „ȃN) (2007) ȸƚවȌʃβ
 
 ǤÒR  2015 ʥׅώǪN > 40 3 427 C ACR Zhang 2001 ě˜N > 65 1 781 M Framingham ɜ͟

ᅆۘऺʃβ

 ȕʑᖽ  2013 Z#N,ľ > 40 1 499 M ACR(2000) źè  2011 Ë}śׅẮÒ > 30 4 473 M Framingham ɜ͟ ቢN ᅆۘऺʃβ

 ƿȣ൦  2007 Z#Nͥᯨľ > 40 897 C ůϣᾬě˜Ŀ┦᫂  źγ)  2014 ĂśׅᾸ*N > 40 600 M ACR Lඈʃβ

 2  2011 Z#Nᾎľ > 60 3 343 C Œ Ŀ ƚĆ ʃβ  NJċ  2015 ͬě 4 N(ŬǪǧ3 > 40 3 382 S  Œ Ŀ ƚ Ć ʃ β (2007) ãȃ3̔ʥ3ࢪՋˏ) (2007)

ᜬͼ M &̶⓺ɉϘ๨╓ƶġʳC &Ϙ๨╓ƶġʳS &੄ř╓ƶġʳACR &๒ę‚ī҉ƚĆ4

ᜬ 2 ę໅À¦๨ၡ͟ᅆɜ͟ᅆ̺Àܸɳ/˯҉ɋ (%) ᜬ 3 ę໅À¦๨ၡ͟ᅆɜ͟ᅆ̺śě5˯҉ɋ (%) Table 3 The prevalence rate of knee osteoarthritis in the Table 2 The prevalence rate of knee osteoarthritis in the middle-aged and elderly in China in different sex and age groups middle-aged and elderly in southern and northern China

Àܸɉ (ʵ) ϻɳ Ώɳ ʇĿ Àܸɉ(ʵ) ě5 ś5

40
49 4.3 8.8 6.5 ϻɳ Ώɳ ʇĿ ϻɳ Ώɳ ʇĿ 50
59 6.7 16.2 12.6 40
49 5.3 12.0 7.1 3.5 7.0 5.8 60
69 8.3 18.0 15.2 50
59 6.3 14.6 11.8 7.0 17.1 13.5

70
79 14.5 28.1 23.6 60
69 15.6 33.4 23.1 7.6 16.0 13.0 80 27.3 42.7 36.4 70
79 16.3 30.1 24.7 14.0 27.4 23.2 80 23.2 41.9 35.7 28.0 42.8 36.5 Ȍᩥ 12.3 22.2 17.0 Ȍᩥ 12.2 21.4 16.1 12.3 23.1 18.0

ᜬ 4 ę໅À¦๨ၡ͟ᅆɜ͟ᅆ̺ΈǍǎǪN˯҉ɋ (%) 17.5%) Ώɳ&24.3%(95%CI18.4%
30.2%)4ၡ͟ᅆ Table 4 The prevalence rate of knee osteoarthritis in the ɜ͟ᅆ̺ńϻɳ¦๨3Ώɳ¦๨ǎʇĿ¦๨ţɌɴΈǍ middle-aged and elderly in rural and urban China ǎǪN7Ⓒ˯҉ɋ:Ŏ\ºጛɳ͛5(P > 0.05)4

Àܸɉ(ʵ) ΈǍ ǪN

ϻɳ Ώɳ ʇĿ ϻɳ Ώɳ ʇĿ 3

ᩬ᩾

Discussion 40
49 4.8 5.6 5.2 4.5 8.8 7.3 ɜ͟ᅆ̺«Ǖϣz໅À¦๨Ո„ᢅ҉3̶Ǖ҉ Ñ ᅆḳɜǜɳ3۸ūÑǎɜᯬʺϣ&ĽǍ «š᰻໅À͟ 13.0 18.3 8.8 19.9 14.3 7.7 0
59 5 60
69 14.4 36.7 33.2 13.1 25.2 20.0 ၡ͟ᅆҀҟՈ'ᡅƣü4╓؄ęͱ¦ǧ໅ܸĚẟ࣏aᱏ¦ 27.1 30.1 20.1 41.6 38.3 18.1 0
79 7 80 30.6 50.3 43.9 32.1 43.1 39.0 ¤ₑ ၡ͟ᅆɜ͟ᅆ̺ȭ໅À¦ϣϏᯬₓՈƽˑ’aᱏ Ȍᩥ 15.4 28.1 23.6 13.7 24.3 20.0 ₑ ÂỔ¼šǕËͯՈࠂĆ⒲L4&ẟPǹrᢧęͱၡ ᅆɜ͟ᅆ̺Ոϕᜐ҉ƚĽͥ ƨۘऺỞẋȴǚę2001͟

654 ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH g Tie XJ, Zheng RG, Zhao M, Han YJ, Guo HL, Wang ZZ, Ma GJ. Prevalence of knee osteoarthritis in the middle-aged and elderly in China: a Meta-analysis. Zhongguo Zuzhi Gongcheng Yanjiu. 2018;22(4):650-656.DOI:10.3969/j.issn.2095-4344. 0105

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P.O. Box 10002, Shenyang 110180 www.CRTER.org 655 bɃş ᾕΞæ ᰹̢ ⚭†· ᾱξš ɏ͏φ Ƞęȭ. ę໅À¦ၡ͟ᅆɜ͟ᅆ̺˯҉ɋՈ Meta Ȍ[J]. ęඈඋ1࣏ۘऺ 2018 22(4):650-656.DOI:10.3969/j.issn.2095-4344.0105

Ⴘ᫦Ƀ̮Ρ~ˎiƏȅā ̈́vɫĝîſ:ƹŦs [14] ȕʑᖽ,ᇉņ¡,Ůɳ˱,਍.Z⍦ࠂľ໅À¦๨ၡɜ͟ᅆ̺ŵ ,Lj̧Ȓ ┭ü௤Ոϕᜐ҉ƚۘऺ[J].Z#Ở̓ƚƚĉ(ĿƚČ), 2013 ǧƨĔΚŜŨ ň້ᯥDzǶ̔μY̓ëǝÉαôè ɻ fɻZŢjɰ ĵɣ ˚Θ» ˊ̘ƚ ɎƍƝ Ȥˋ“Y̓ë 33(3):318-322. ǝôè ͯʑ ǧƨĔΚZ˚Θ»Y̓ƉƘõƅΛÔ̖ [15] ƿȣ൦,ɏˌ,⓲ɍ˪,਍.Z#NͥᯨľΈǍ໅À¦ɜ͟ᅆ̺˯ ඓ᯽Γťȶɻģɐu4ěQ˽lǦŦs ҉ɋǎ OɴΡ[J].ęήɳ҉8⓶^ȋ:, 2007, 15(1):60-61. -֎ΞॅƖuȔŀʃȅRæɻģʕ˵ʩŶ-‚Ȕ [16] 2,ƭࢄݍ,Ŭ๒ᅵ,਍.Z#Nᾎľ໅À¦ၡ͟ᅆɜ͟ᅆ̺ɴ˯᫇ Ēˊ⒲LɻģĝLj̧%Θ͑ȷ̢ɻģȎėƤˊȌǸĵ˼Ϥ ɡ[J].ę͔࢕Ŀƚ, 2011,14(29):3374-3376. 1ǫʭQəʷNj(PRISMA ŷ˂) [17] ᇇ˴,ݎĢĢ,8̡ᅡ,਍.Z#Nȏࠂľ໅Àၡɜ͟ᅆ̺ϕᜐ҉ƚ তɡₑɻģ“1νlˎ CNKI ljɘϡɻˬϗ!ˊȌY̓ 3 ᫇ɡ[J].ęĿሳʬᩳ, 2010, 2(31):317-318. É(Ɨ [18] ƍ൦,ϴ,ĢċŒ,਍. ࠂľɹʥၡ͟ᅆɜɳ͟ᅆ̺ϕᜐ҉ƚ᫇ɡ ত̲Ǖɻģlˋˍ̔ȅ̓ȻÔDžνňȹȻÔKȐ˾ÌƷɘ Ȍ[J].#śĿƚ, 2013, 24(7):312-313. ǷŻ [19] -Ïċ,ปŠ,ᆛ̯,਍.ŏNปĂľ50ʵÑZ໅À¦ၡ͟ᅆɜɳ͟ ň້̌ŠijȔŀƋΡ~˼Lj̧ĝȒɻƏ“˫ĝ^Ƃ̓ɡmü ᅆ̺ϕᜐ҉ƚ᫇ɡǎϣƌᯬₓ᪈ã[J]. ɴÏĿሳůϣ, 2014, óQȒɻƏÇΛĝ°ûȕ͛ ļœ(Gģαƀ·ļœÿ)βdzΛϊ 30(18):2771-2773. .[ǫ̂˼̏ͦKæ4ě˺( [20] Ⴋ⑃#,źÒĴ,NJɃ̤,਍. ͆ƣŌľɜ͟ᅆ̺ϕᜐ҉ƚۘऺ[J cĶuʩʷşLá তČƿɻģ“1νÖŽ.ǠȔŀę+NζįƤ1+˵ʩ ʥᡃĿሳƾȣ, 2006, 35(9):767-770. ̠0 [21] ƿ௤ᄷ,z௤☝,ņ¡,਍.̔ʥŌľ໅Àၡɜɳ͟ᅆ̺ϕᜐ҉ƚ .Ō΢ቻǚ̌ŠŃĆ͙Çǚ;$ɻģKɬœũõʃ̂͠æ̠ ǎּ͟ü௤᫇ɡ[J].ĿƚǍʻ, 2013,(11):250-251 0 įʐ)ǜ­Ϥ͇øh)˵ȅǒüʃ̂3.0ǰċKÝ˾ŨDhĝ [22] ƿ█ᆵ, NJ▮̤, ¡⓷,਍. ⑃ṟãŌľ60ʵǎÑZ¦๨ၡƣǕ ē˗KÍ͠ƘNǜ­Ϥ͇ʲĝΆ°ɻˍ`%Θ ŐŜ˼ĤĚKȅ ɳɜ͟ᅆ̺˯҉ɋ᫇ɡǎƽˑü௤ Ȍ[J].Œ໅ÀĿƚƾȣ, ðÍ͠Q˽h̴ÇŸ ˗Û Ú] ¦Ķ íF ϗƔ IΡƍ4ȶ 2011, 30(2):172-174. Ōľ˝K໅À¦ɜ͟ᅆ̺Ո ŻƔDKhȔp
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