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FEEVA GA, 2019 Birmingham Claire Scicluna I HAD A DREAM… EASY PHENYLBUTAZONE PHENYLBUTAZONE FEEVA GA, 2019 SERIES Birmingham PBZ story PBZ story PBZ story PBZ story FEEVA GA, 2019 PHENYLBUTAZONE Birmingham Drug properties Drug efficacy Exclusion from food Drug cost & use chain Traceability Regulations Horse problems Horse welfare Vet problems Vet welfare FEEVA GA, 2019 PHENYLBUTAZONE Birmingham Efficacy Cost Human health Need in practice safety Vet safety / regulations Drug economy market FVE/FEEVA position Efficacy proof paper PHENYLBUTAZONE EFFICACY FEEVA GA, 2019 STUDY Birmingham PBZ vs other NAIDs Multicentric clinical study Dechra implication French drug agency approved COMPARATIVE FLUNIXIN / MELOXICAM / PBZ EFFICACY FOR EQUINE LAMINITIS AND LAMENESS PHENYLBUTAZONE EFFICACY FEEVA GA, 2019 STUDY Birmingham COMPARATIVE FLUNIXIN / MELOXICAM / PBZ EFFICACY FOR EQUINE LAMINITIS AND LAMENESS Confirm PBZ efficacy in horses with laminitis and other causes of lameness Compare efficacy of PBZ, flunixin and meloxicam after oral administration of oral in horses with laminitis or lameness Compare onset of action of these 3 NSAIDs administered orally for treatment of laminitis or lameness Compare duration of action of PBZ, flunixin and meloxicam, in equine laminitis Compare ease of administration and observance of the 3 NSAID treatments in horses with laminitis or lameness PHENYLBUTAZONE EFFICACY FEEVA GA, 2019 STUDY Birmingham COMPARATIVE FLUNIXIN / MELOXICAM / PBZ EFFICACY FOR EQUINE LAMINITIS AND LAMENESS Horses examined for laminitis or lameness 60 horses (15 horses/group, 4 groups : In each group will be included at least 8 laminitis) Diagnosis of lameness or laminitis Examinations / treatments / videos Blinded treatments / blinded scoring PHENYLBUTAZONE EFFICACY FEEVA GA, 2019 STUDY Birmingham COMPARATIVE FLUNIXIN / MELOXICAM / PBZ EFFICACY FOR EQUINE LAMINITIS AND LAMENESS Preliminary results PHENYLBUTAZONE EFFICACY FEEVA GA, 2019 STUDY Birmingham COMPARATIVE FLUNIXIN / MELOXICAM / PBZ EFFICACY FOR EQUINE LAMINITIS AND LAMENESS Preliminary results PHENYLBUTAZONE EFFICACY FEEVA GA, 2019 STUDY Birmingham COMPARATIVE FLUNIXIN / MELOXICAM / PBZ EFFICACY MeloxicamFOR EQUINE LAMINITIS AND LAMENESS PBZ Flunixine PHENYLBUTAZONE FEEVA GA, 2019 SERIES Birmingham LAST SEASON ? Miss Bute MAKE IT EASY !.

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Recommendations for the Diagnosis and Treatment of Equine Metabolic Syndrome (EMS)
Recommendations for the Diagnosis and Treatment of Equine Metabolic Syndrome (EMS) 2016 GROUP GROUP Recommendations for the Diagnosis and Treatment of Equine Metabolic Syndrome (EMS) June 2016 Prepared by the EMS Working Group Nicholas Frank (Group Coordinator; Tufts University), Simon Bailey (University of Melbourne), Andy Durham (Liphook Equine Hospital), Janice Kritchevsky (Purdue University), Nicola Menzies-Gow (Royal Veterinary College), and Lisa Tadros (Michigan State University) Introduction Equine metabolic syndrome (EMS), which is characterized by insulin dysregulation, abnormal adipose distribution, and a high risk for laminitis, results from an interaction between genetics and environment. The risk of laminitis in the individual animal therefore depends on the relative weighting of genetic and environmental influences. We can identify high-genetic risk animals that develop EMS with only mild environmental influences, and early detection is essential in these animals. Other horses have a lower genetic influence, but can develop EMS through exposure to improper environments (diets that provide more calories than an animal requires and are high in non-structural carbohydrates). It might therefore be assumed that any horse can develop EMS if pushed far enough in the wrong direction by improper management and exposure to environmental factors. Epigenetic influences on gene expression might also further the development of EMS. The Equine Endocrinology Group (EEG) is composed of experts in the field of equine endocrinology who provide advice in the form of written guidelines to help veterinary practitioners diagnose and manage equine endocrine disorders. Guidelines are updated every two years or when new information becomes available, and can be found on the EEG web site: http://sites.tufts.edu/equineendogroup.
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The Relationship Between Equine Diet and Presentation Of
THE RELATIONSHIP BETWEEN EQUINE DIET AND PRESENTATION OF LAMINITIS A Thesis Submitted to the Kent State University Honors College in partial fulfillment of the requirements for Departmental Honors by Molly Corder April, 2015 Thesis written by Molly Corder Approved by ________________________________________________________________, Advisor _____________________________________, Chair, Department of Biological Sciences Accepted by _____________________________________________________, Dean, Honors College ii Table of Contents LIST OF FIGURES……………………………………………………………………. iv LIST OF TABLES……………………………………………………………………... v PREFACE OR ACKNOWLEDGEMENT……………………………………………...vi CHAPTER I. Abstract………………………………………………………………………. 1 II. Introduction…………………………………………………………………. 2 III. Materials and Methods……………………………………………………... 13 IV. Results……………………………………………………………………… 19 V. Discussion…………………………………………………………………… 27 VI. Management Techniques for Laminitis Prevention………………………… 35 WORKS CITED…………………………………………………………………….….. 41 APPENDIX….………………………………………………………………………….. 46 iii LIST OF FIGURES Figure 1. Lateroventral View of the Laminar Tissue……………………………...…….. 3 Figure 2. Anatomy of Laminar Tissue…………………………………………..………. 5 Figure 3. Typical Laminitis Stance…………………………………………………..….. 7 Figure 4. Nutrena’s Feed Room Reference……………………………………………... 15 Figure 5. Hoof Sensitivity Test……………………………………………………...….. 18 Figure 6. Feed Comparison…………………………………………………………….. 23 Figure 7. Average Daily Exercise……………………………………………………… 23 Figure 8. Ratio of total daily caloric intake to average
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Preventing Laminitis Many of You; Laminitis
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Endocrinopathic Laminitis, Obesity-Associated Laminitis, and Pasture-Associated Laminitis
IN-DEPTH: LAMINITIS FOR THE PRACTITIONER Endocrinopathic Laminitis, Obesity-Associated Laminitis, and Pasture-Associated Laminitis Nicholas Frank, DVM, PhD, Diplomate ACVIM Author’s address: Department of Large Animal Clinical Sciences, University of Tennessee, 2407 River Drive, Knoxville, TN 37996; e-mail: [email protected]. © 2008 AAEP. 1. Introduction measuring blood insulin concentrations, which are In a recent online survey, we asked equine practi- usually elevated in affected horses. We hypothe- tioners to list the three most common causes of size that IR is the key determinant of laminitis sus- laminitis in horses seen within their practice. We ceptibility in horses, and this explains why speciﬁc expected veterinarians to list colitis, colic, and re- animals within a herd develop disease. This hypoth- tained placenta as the primary causes of laminitis, esis is supported by evidence that insulin-resistant but many respondents listed obesity, insulin resis- ponies are more likely to develop pasture-associated tance (IR), equine metabolic syndrome (EMS), pitu- laminitis and that laminitis can be experimentally itary pars intermedia dysfunction (PPID), and lush induced by infusing insulin intravenously.1,2 pasture. These results reﬂect the prevalence of en- Obesity-associated laminitis is a useful term be- docrine/metabolic problems in horses that are seen cause obesity is easily recognized, and owners can in general practice. We will examine these prob- address this issue to reduce the risk of laminitis. lems and discuss the potential mechanisms involved However, it has not been established whether obe- in endocrinopathic laminitis. sity per se raises the risk of laminitis or whether the disease is caused by IR, which is more common in 2.
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Equine Laminitis John Kurt Iowa State University
Volume 37 | Issue 2 Article 5 1975 Equine Laminitis John Kurt Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/iowastate_veterinarian Part of the Large or Food Animal and Equine Medicine Commons, and the Veterinary Pathology and Pathobiology Commons Recommended Citation Kurt, John (1975) "Equine Laminitis," Iowa State University Veterinarian: Vol. 37 : Iss. 2 , Article 5. Available at: https://lib.dr.iastate.edu/iowastate_veterinarian/vol37/iss2/5 This Article is brought to you for free and open access by the Journals at Iowa State University Digital Repository. It has been accepted for inclusion in Iowa State University Veterinarian by an authorized editor of Iowa State University Digital Repository. For more information, please contact [email protected]. Equine Laminitis by John Kurt* Larry L. Jackson, D.V.M.t Laminitis is defined as the inflamm:a horse is accustomed. All types of grain tion of the lami11ae of the foot. This dis and animal feeds ,can cause this type of ease, commonly known as founder, has founder although oats !and bran are prob been known for centuries, however the ably the least offensive. The consumption pathogenesis is still under discussion. leads to a gastroenteritis which, accord Both cardiovascular as well 'as metabolic in,g to different authors, initiates hista changes are known to be involved in the m'ine release, leads to a bacterial entero disease.! Capillary perfusion to the lam toxemia and/or even an immune response inar corium is decreased in many ways. to the protein of the bacteria itself. This Histamine released from hypoxic mast type of founder is believed by some to de cells causes ,capillary dilation.
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Equine Laminitis Managing Pasture to Reduce the Risk
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Laminitis and the Equine Metabolic Syndrome
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Equine Metabolic Syndrome
Fact Sheet Fact Sheet ChokEequine Metabolic Choke is a relatively common condition seen in horses and ponies and is typically caused by obstruction of the oesophagus (food pipe) with food; occasionally a foreign body can be involvedS e.g. yndromewood or plastic. Fortunately many cases of chokeEquine resolv eMetabolic quickly and Syndrome spontaneously (EMS) is a condition which has only and only cases in whichbecome the obst recognisedruction lasts in recent for longer years. EMS is usually seen in overweight than 30 minutes are horseslikely to and require ponies. vete Fatrina whichry assistanc is laid edown. around the body becomes It is important to notehormonally that this is active not the and same excretes as the hormone-like chemicals which interfere with life-threatening conditionnormal in sugarhuman ands, where fat metabolism. the term The result is an individual that continues to put on weight “choke” refers to bloandckage will, of eventually, the windpipe show rather signs than of laminitis.the It has similarities to Type 2 diabetes in humans. oesophagus. This difference means that unlike humans, EMS in natural living, wild, native ponies is normal. It allows them to put on weight in the horses with choke can still breathe. summer and then use these fat reserves in the winter months when food is in shorter supply. Our domestication of horse and ponies – rugging up and liberal feeding all year round – interferes with this natural mechanism. CLINICAL SIGNS: DIAGNOSIS Clinical signs: • overweight As well as the clinical signs, laboratory tests • firm and sensitive fat on neck crest can be helpful in confirming a diagnosis.
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Are Drugs Effective Treatment for Horses with Acute Laminitis?
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Potomac Horse Fever)
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Insulin Resistance and Laminitis in Horses
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Equine Insulin Resistance and the Role the Farrier Plays with This Disease
Equine Insulin Resistance And the Role the Farrier Plays with this Disease The most common cause of Laminitis today is via the disease Equine Insulin Resistance. Horses of any age can be effected by it. Older horses (>15 years old may have this problem and Equine Cushings disease together. Equine Insulin Resistance (EIR) leads to a pathological elevation of blood Insulin leading directly to Laminitis. Studies just a few years ago in Australia documented that a bolus of Insulin given IV caused Laminitis in all four feet within twenty-four hours. Signs of EIR: 1. Overweight, Fat pads on butt/shoulders 2. Easy keeper – little food but large 3. Laminitis on grass, now on dirt lot while others outside 4. Sore feet after routine trims from talented farrier 5. Stretched white line – high Insulin stretches laminae so bonds are not strong 6. Chronic white line disease 7. Laminitis – acute and chronic 8. High blood Insulin 9. Sore on hard ground or frozen ground 10. On Pergolide but still founders What causes Insulin to be so high to create Laminitis? Due to several possible triggers, there has been interference with Insulin’s normal action. Insulin has several roles, with carbohydrate (sugar) transport to cells being its main job – sugar absorbed from the meal enters the blood stream, signaling the Pancreas to send out Insulin to escort nutrients to cells. Once at the cell, a lock and key system is in place, with Insulin the key opening the lock to allow glucose sugar inside. When the lock and key setup is interfered with, the Pancreas sees that glucose is still in the bloodstream, so it pours more and more Insulin out into the bloodstream to force glucose in – basically more keys put into play.
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