bioRxiv preprint doi: https://doi.org/10.1101/616789; this version posted April 23, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Smear positive tuberculosis and genetic diversity of M. tuberculosis isolates 2 in individuals visiting health facilities in South Gondar Zone, northwest 3 Ethiopia 4 Amir Alelign1, 2, 3*, Beyene Petros2 and Gobena Ameni1 5 6 1Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis 7 Ababa, Ethiopia; 8 2College of Natural Sciences, Department of Microbial, Cellular and Molecular Biology, 9 Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia; 10 3 College of Natural and Computational Sciences, Department of Biology, Debrebrhan 11 University, P.O. Box 445, Debrebrhan, Ethiopia. 12 13 * Corresponding author 14 15 16 Email addresses 17 AA:
[email protected] 18 GA:
[email protected] 19 BP: abule2002@ yahoo.com 20 21 22 23 24 25 26 27 28 1 bioRxiv preprint doi: https://doi.org/10.1101/616789; this version posted April 23, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Abstract 2 Background: Tuberculosis (TB), a bacterial infectious disease, persisted to be a public 3 health concern in many developing countries.