MINIREVIEWS Carbapenemase-Producing Klebsiella pneumoniae, a Key Johann D. D. Pitout, Patrice 5873–5884 Pathogen Set for Global Nosocomial Dominance Nordmann, Laurent Poirel Potential Targets for Antifungal Drug Discovery Based on Xiuyun Li, Yinglong Hou, Longtao Yue, 5885–5891 Growth and Virulence in Candida albicans Shuyuan Liu, Juan Du, Shujuan Sun Addressing Therapeutic Options for Ebola Virus Infection in Azizul Haque, Didier Hober, Joel 5892–5902 Current and Future Outbreaks Blondiaux CHALLENGING CLINICAL CASES IN ANTIMICROBIAL RESISTANCE Successful Treatment of Carbapenemase-Producing Pandrug- Jose F. Camargo, Jacques Simkins, 5903–5908 Resistant Klebsiella pneumoniae Bacteremia Thiago Beduschi, Akin Tekin, Laura Aragon, Armando Pérez-Cardona, Clara E. Prado, Michele I. Morris, Lilian M. Abbo, Rafael Cantón (Commentator) MECHANISMS OF ACTION: PHYSIOLOGICAL EFFECTS Garcinia xanthochymus Benzophenones Promote Hyphal Desmond N. Jackson, Lin Yang, 6032–6038 Apoptosis and Potentiate Activity of Fluconazole against ShiBiao Wu, Edward J. Kennelly, Candida albicans Bioﬁlms Peter N. Lipke Differential Effects of Penicillin Binding Protein Deletion on the George Sakoulas, Monika 6132–6139 Susceptibility of Enterococcus faecium to Cationic Peptide Kumaraswamy, Poochit Nonejuie, Antibiotics Brian J. Werth, Micahel J. Rybak, Joseph Pogliano, Louis B. Rice, Victor Nizet Subinhibitory Doses of Aminoglycoside Antibiotics Induce Sheng-Hui Tsai, Hsin-Chih Lai, 6161–6169 Changes in the Phenotype of Mycobacterium abscessus Shiau-Ting Hu New Insights Regarding Yeast Survival following Exposure to Rita Teixeira-Santos, Elisabete Ricardo, 6181–6187 Liposomal Amphotericin B Susana Gomes Guerreiro, Soﬁa Costa-de-Oliveira, Acácio Gonçalves Rodrigues, Cidália Pina-Vaz The Glucose Transporter PfHT1 Is an Antimalarial Target of the Thomas E. Kraft, Christopher 6203–6209 HIV Protease Inhibitor Lopinavir Armstrong, Monique R. Heitmeier, Audrey R. Odom, Paul W. Hruz Key Residues of Outer Membrane Protein OprI Involved in Ting-Wei Chang, Chiu-Feng Wang, 6210–6222 Hexamer Formation and Bacterial Susceptibility to Cationic Hsin-Jye Huang, Iren Wang, Shang-Te Antimicrobial Peptides Danny Hsu, You-Di Liao An Antifungal Benzimidazole Derivative Inhibits Ergosterol Petra Keller, Christoph Müller, Isabel 6296–6307 Biosynthesis and Reveals Novel Sterols Engelhardt, Ekkehard Hiller, Karin Lemuth, Holger Eickhoff, Karl-Heinz Wiesmüller, Anke Burger-Kentischer, Franz Bracher, Steffen Rupp Elevated Expression of GlpT and UhpT via FNR Activation Kumiko Kurabayashi, Koichi 6352–6360 Contributes to Increased Fosfomycin Susceptibility in Tanimoto, Shinobu Fueki, Haruyoshi Escherichia coli under Anaerobic Conditions Tomita, Hidetada Hirakawa Copper(II)-Bis(Thiosemicarbazonato) Complexes as Karrera Y. Djoko, Maira M. Goytia, 6444–6453 Antibacterial Agents: Insights into Their Mode of Action and Paul S. Donnelly, Mark A. Schembri, Potential as Therapeutics William M. Shafer, Alastair G. McEwan

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Antibacterial Action of Nitric Oxide-Releasing Chitosan Katelyn P. Reighard, Mark H. 6506–6513 Oligosaccharides against Pseudomonas aeruginosa under Schoenﬁsch Aerobic and Anaerobic Conditions MECHANISMS OF RESISTANCE Caspofungin Treatment of Aspergillus fumigatus Results in Louise A. Walker, Keunsook K. Lee, 5932–5941 ChsG-Dependent Upregulation of Chitin Synthesis and the Carol A. Munro, Neil A. R. Gow Formation of Chitin-Rich Microcolonies Multidrug Transporters and Alterations in Sterol Biosynthesis Elizabeth L. Berkow, Kayihura 5942–5950 Contribute to Azole Antifungal Resistance in Manigaba, Josie E. Parker, Katherine S. Candida parapsilosis Barker, Stephen L. Kelly, P. David Rogers Phylogeny and Comparative Genomics Unveil Independent Teresa G. Ribeiro, Ângela Novais, 5951–5958 Diversiﬁcation Trajectories of qnrB and Genetic Platforms Raquel Branquinho, Elisabete within Particular Citrobacter Species Machado, Luísa Peixe Can Plazomicin Alone or in Combination Be a Therapeutic Cristina García-Salguero, Iciar 5959–5966 Option against Carbapenem-Resistant Rodríguez-Avial, Juan J. Picazo, Esther Acinetobacter baumannii? Culebras

Residues Distal to the Active Site Contribute to Enhanced Dandan He, Jiachi Chiou, Zhenling 5976–5983 Catalytic Activity of Variant and Hybrid ␤-Lactamases Derived Zeng, Lanping Liu, Xiaojie Chen, Li from CTX-M-14 and CTX-M-15 Zeng, Edward Wai Chi Chan, Jian-Hua Liu, Sheng Chen Inﬂuence of the yjiL-mdtM Gene Cluster on the Antibacterial Andor Krizsan, Daniel Knappe, Ralf 5992–5998 Activity of Proline-Rich Antimicrobial Peptides Overcoming Hoffmann Escherichia coli Resistance Induced by the Missing SbmA Transporter System Genomic and Functional Portrait of a Highly Virulent, Amit Ranjan, Sabiha Shaik, Arif 6087–6095 CTX-M-15-Producing H30-Rx Subclone of Escherichia coli Hussain, Nishant Nandanwar, Torsten Sequence Type 131 Semmler, Savita Jadhav, Lothar H. Wieler, Niyaz Ahmed Delicate Metabolic Control and Coordinated Stress Response Peng Li, Chaminda J. Seneviratne, 6101–6112 Critically Determine Antifungal Tolerance of Candida albicans Emanuele Alpi, Juan A. Vizcaino, Lijian Bioﬁlm Persisters Jin Antimicrobial Susceptibility and SOS-Dependent Increase in Jenny Yang, Thirunavukkarasu 6195–6202 Mutation Frequency Are Impacted by Escherichia coli Annamalai, Bokun Cheng, Srikanth Topoisomerase I C-Terminal Point Mutation Banda, Rakhi Tyagi, Yuk-Ching Tse-Dinh Modulation of ccrAB Expression and SCCmec Excision by an Shijie Zhang, Ronghua Ma, Xiaoyu Liu, 6223–6232 Inverted Repeat Element and SarS in Methicillin-Resistant Xu Zhang, Baolin Sun Staphylococcus aureus Mutations in ␤-Lactamase AmpC Increase Resistance of M. Berrazeg, K. Jeannot, Véronique 6248–6255 Pseudomonas aeruginosa Isolates to Antipseudomonal Yvette Ntsogo Enguéné, I. Broutin, S. Cephalosporins Loeffert, D. Fournier, P. Plésiat Detection of a New cfr-Like Gene, cfr(B), in Enterococcus Lalitagauri M. Deshpande, Deborah S. 6256–6261 faecium Isolates Recovered from Human Specimens in the Ashcraft, Heather P. Kahn, George United States as Part of the SENTRY Antimicrobial Surveillance Pankey, Ronald N. Jones, David J. Program Farrell, Rodrigo E. Mendes

The Human Gut Microbiome as a Transporter of Antibiotic Johan Bengtsson-Palme, Martin 6551–6560 Resistance Genes between Continents Angelin, Mikael Huss, Sanela Kjellqvist, Erik Kristiansson, Helena Palmgren, D. G. Joakim Larsson, Anders Johansson

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Candida parapsilosis Resistance to Fluconazole: Molecular Ana Carolina R. Souza, Beth Burgwyn 6581–6587 Mechanisms and In Vivo Impact in Infected Galleria mellonella Fuchs, Henrique M. S. Pinhati, Larvae Ricardo A. Siqueira, Ferry Hagen, Jacques F. Meis, Eleftherios Mylonakis, Arnaldo L. Colombo

IncA/C Plasmid Carrying blaNDM-1, blaCMY-16, and fosA3 in a L. Villa, B. Guerra, S. Schmoger, J. 6597–6600 Salmonella enterica Serovar Corvallis Strain Isolated from a Fischer, R. Helmuth, Z. Zong, A. Migratory Wild Bird in Germany García-Fernández, A. Carattoli Emergence of Extensively Drug-Resistant Proteus mirabilis Shangshang Qin, Hui Qi, Qijing Zhang, 6601–6604 Harboring a Conjugative NDM-1 Plasmid and a Novel Di Zhao, Zhen-Zhen Liu, Hao Tian, Salmonella Genomic Island 1 Variant, SGI1-Z Lijuan Xu, Hui Xu, Mengmeng Zhou, Xianju Feng, Hong-Min Liu

A Plasmid Bearing the blaCTX-M-15 Gene and Phage P1-Like Juyoun Shin, Kwan Soo Ko 6608–6610 Sequences from a Sequence Type 11 Klebsiella pneumoniae Isolate A Novel Y319H Substitution in CYP51C Associated with Azole R. A. Paul, S. M. Rudramurthy, J. F. 6615–6619 Resistance in Aspergillus ﬂavus Meis, J. W. Mouton, A. Chakrabarti

Characterization of a Novel Putative Xer-Dependent Integrative Alberto Antonelli, Marco Maria 6620–6624

Mobile Element Carrying the blaNMC-A Carbapenemase Gene, D’Andrea, Vincenzo Di Pilato, Bruno Inserted into the Chromosome of Members of the Enterobacter Viaggi, Francesca Torricelli, Gian Maria cloacae Complex Rossolini Characterization of an Enterobacter cloacae Strain Producing Wenjing Wu, Yu Feng, Alessandra 6625–6628 both KPC and NDM Carbapenemases by Whole-Genome Carattoli, Zhiyong Zong Sequencing Fluconazole and Voriconazole Resistance in Candida Joana Branco, Ana P. Silva, Raquel M. 6629–6633 parapsilosis Is Conferred by Gain-of-Function Mutations in Silva, Ana Silva-Dias, Cidália Pina-Vaz, MRR1 Transcription Factor Gene Geraldine Butler, Acácio G. Rodrigues, Isabel M. Miranda Constitutive and Inducible Expression of the rRNA Methylase Fengru Deng, Jianzhong Shen, Maojun 6661–6664 Gene erm(B) in Campylobacter Zhang, Congming Wu, Qijing Zhang, Yang Wang SUSCEPTIBILITY Antimicrobial Activity of Fosfomycin-Tobramycin María Díez-Aguilar, María Isabel 6039–6045 Combination against Pseudomonas aeruginosa Isolates Assessed Morosini, Ana P. Tedim, Irene by Time-Kill Assays and Mutant Prevention Concentrations Rodríguez, Zerrin Aktas¸, Rafael Cantón Potent Ex Vivo Activity of Naphthoquine and Methylene Blue Grennady Wirjanata, Boni F. Sebayang, 6117–6124 against Drug-Resistant Clinical Isolates of Plasmodium Ferryanto Chalfein, Prayoga, Irene falciparum and Plasmodium vivax Handayuni, Leily Trianty, Enny Kenangalem, Rintis Noviyanti, Brice Campo, Jeanne Rini Poespoprodjo, Jörg J. Möhrle, Ric N. Price, Jutta Marfurt

The Oral Antimalarial Drug Tafenoquine Shows Activity against Luis Carvalho, Marta Martínez-García, 6151–6160 Trypanosoma brucei Ignacio Pérez-Victoria, José Ignacio Manzano, Vanessa Yardley, Francisco Gamarro, José M. Pérez-Victoria In Vitro Activities of Tedizolid and Linezolid against Gram- Ko-Hung Chen, Yu-Tsung Huang, 6262–6265 Positive Cocci Associated with Acute Bacterial Skin and Skin Chun-Hsing Liao, Wang-Hui Sheng, Structure Infections and Pneumonia Po-Ren Hsueh Potent In Vitro Antiproliferative Synergism of Combinations of S. T. de Macedo-Silva, G. Visbal, J. A. 6402–6418 Ergosterol Biosynthesis Inhibitors against Leishmania Urbina, W. de Souza, J. C. F. Rodrigues amazonensis

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N-Chlorotaurine Exhibits Fungicidal Activity against Therapy- Michaela Lackner, Ulrike Binder, 6454–6462 Refractory Scedosporium Species and Lomentospora proliﬁcans Martin Reindl, Beyhan Gönül, Hannes Fankhauser, Christian Mair, Markus Nagl Effects of Iron Chelators on the Formation and Development of Hasan Nazik, John C. Penner, Jose A. 6514–6520 Aspergillus fumigatus Bioﬁlm Ferreira, Janus A. J. Haagensen, Kevin Cohen, Alfred M. Spormann, Marife Martinez, Vicky Chen, Joe L. Hsu, Karl V. Clemons, David A. Stevens Rapid, Semiquantitative Assay To Discriminate among Ben Gold, Julia Roberts, Yan Ling, 6521–6538 Compounds with Activity against Replicating or Nonreplicating Landys Lopez Quezada, Jou Glasheen, Mycobacterium tuberculosis Elaine Ballinger, Selin Somersan-Karakaya, Thulasi Warrier, J. David Warren, Carl Nathan Carbapenems and Rifampin Exhibit Synergy against Amit Kaushik, Nayani Makkar, Pooja 6561–6567 Mycobacterium tuberculosis and Mycobacterium abscessus Pandey, Nicole Parrish, Urvashi Singh, Gyanu Lamichhane

First Report of Ceftazidime-Avibactam Resistance in a KPC-3- Romney M. Humphries, Shangxin 6605–6607 Expressing Klebsiella pneumoniae Isolate Yang, Peera Hemarajata, Kevin W. Ward, Janet A. Hindler, Shelley A. Miller, Aric Gregson In Vitro Activities of Eight Antifungal Drugs against a Global Anuradha Chowdhary, Ferry Hagen, 6642–6645 Collection of Genotyped Exserohilum Isolates Ilse Curfs-Breuker, Hugo Madrid, G. Sybren de Hoog, Jacques F. Meis BIOLOGIC RESPONSE MODIFIERS Role of Interleukin-12 in Protection against Pulmonary Quang-Tam Nguyen, Yoichi Furuya, 6308–6316 Infection with Methicillin-Resistant Staphylococcus aureus Sean Roberts, Dennis W. Metzger ANALYTICAL PROCEDURES Fast and Accurate Large-Scale Detection of ␤-Lactamase Genes Jae Jin Lee, Jung Hun Lee, Dae Beom 5967–5975 Conferring Antibiotic Resistance Kwon, Jeong Ho Jeon, Kwang Seung Park, Chang-Ro Lee, Sang Hee Lee Puriﬁcation Methodology for Viable and Infective Plasmodium Omaira Vera, Paula Brelas de Brito, 6638–6641 vivax Gametocytes That Is Compatible with Transmission- Letusa Albrecht, Keillen Monick Blocking Assays Martins-Campos, Paulo F. P. Pimenta, Wuelton M. Monteiro, Marcus V. G. Lacerda, Stefanie C. P. Lopes, Fabio T. M. Costa ANTIVIRAL AGENTS In Vitro Virology Proﬁle of Tenofovir Alafenamide, a Novel Christian Callebaut, George Stepan, 5909–5916 Oral Prodrug of Tenofovir with Improved Antiviral Activity Yang Tian, Michael D. Miller Compared to That of Tenofovir Disoproxil Fumarate Characterization of HIV-1 Resistance to Tenofovir Alafenamide Nicolas A. Margot, Audun Johnson, 5917–5924 In Vitro Michael D. Miller, Christian Callebaut

Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Adam M. Spivak, Alberto Bosque, 5984–5991 Dibenzoate and Panobinostat in Resting CD4؉ T Cells from Alfred H. Balch, David Smyth, Laura Aviremic Patients Martins, Vicente Planelles Novel Ranking System for Identifying Efﬁcacious Anti-Inﬂuenza Alice W. Tsai, Colleen F. McNeil, 6007–6016 Virus PB2 Inhibitors Joshua R. Leeman, Hamilton B. Bennett, Kwame Nti-Addae, Cassey Huang, Ursula A. Germann, Randal A. Byrn, Francoise Berlioz-Seux, Rene Rijnbrand, Michael P. Clark, Paul S. Charifson, Steven M. Jones

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Baseline Polymorphisms and Emergence of Drug Resistance in K. L. Berger, J. Scherer, M. Ranga, 6017–6025 the NS3/4A Protease of Hepatitis C Virus Genotype 1 following N. Sha, J. O. Stern, A.-M. Quinson, Treatment with Faldaprevir and Pegylated Interferon Alpha 2a/ G. Kukolj Ribavirin in Phase 2 and Phase 3 Studies Plasma Tenofovir, Emtricitabine, and Rilpivirine and Laura Dickinson, H. Manisha Yapa, 6080–6086 Intracellular Tenofovir Diphosphate and Emtricitabine Akil Jackson, Graeme Moyle, Laura Triphosphate Pharmacokinetics following Drug Intake Else, Alieu Amara, Saye Khoo, David Cessation Back, Zeenat Karolia, Chris Higgs, Marta Boffito The Flavonoid Isoliquiritigenin Reduces Lung Inflammation Hussein Traboulsi, Alexandre Cloutier, 6317–6327 and Mouse Morbidity during Influenza Virus Infection Kumaraswamy Boyapelly, Marc-André Bonin, Éric Marsault, André M. Cantin, Martin V. Richter Effects of Zidovudine Treatment on Heart mRNA Expression Jacob W. Snowdin, Chia-Heng Hsiung, 6328–6336 and Mitochondrial DNA Copy Number Associated with Daniel G. Kesterson, Vasudeva G. Alterations in Deoxynucleoside Triphosphate Composition in a Kamath, Edward E. McKee Neonatal Rat Model

Pharmacokinetic Modeling of Lamivudine and Zidovudine Julie B. Dumond, Kuo H. Yang, 6395–6401 Triphosphates Predicts Differential Pharmacokinetics in Racheal Kendrick, Y. Sunila Reddy, Seminal Mononuclear Cells and Peripheral Blood Mononuclear Angela D. M. Kashuba, Luigi Troiani, Cells Arlene S. Bridges, Susan A. Fiscus, Alan Forrest, Myron S. Cohen Preclinical Characterization and In Vivo Efficacy of GSK8853, a Jeffrey J. Pouliot, Michael Thomson, 6539–6550 Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein Mi Xie, Joseph Horton, John Johnson, David Krull, Amanda Mathis, Yoshio Morikawa, Derek Parks, Richard Peterson, Takashi Shimada, Elizabeth Thomas, Jessica Vamathevan, Stephanie Van Horn, Zhiping Xiong, Robert Hamatake, Andrew J. Peat Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Sunwen Chou 6588–6593 Mutations That Confer Letermovir Resistance EPIDEMIOLOGY AND SURVEILLANCE Antibiotic Susceptibility and Sequence Type Distribution of Sarah C. Schneider, Regula Tinguely, 6026–6031 Ureaplasma Species Isolated from Genital Samples in Sara Droz, Markus Hilty, Valentina Switzerland Donà, Thomas Bodmer, Andrea Endimiani In Vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/ Douglas J. Biedenbach, Michael D. 6053–6063 Topoisomerase IV Inhibitor, against Clinically Relevant Gram- Huband, Meredith Hackel, Positive and Fastidious Gram-Negative Pathogens Boudewijn L. M. de Jonge, Daniel F. Sahm, Patricia A. Bradford Robust Algorithm for Systematic Classification of Malaria Late Mateusz M. Plucinski, Lindsay Morton, 6096–6100 Treatment Failures as Recrudescence or Reinfection Using Mary Bushman, Pedro Rafael Dimbu, Microsatellite Genotyping Venkatachalam Udhayakumar Epidemiologic Correlates of Pyrazinamide-Resistant Dawn Verdugo, Dorothy Fallows, 6140–6150 Mycobacterium tuberculosis in New York City Shama Ahuja, Neil Schluger, Barry Kreiswirth, Barun Mathema Racial Differences in Clostridium difficile Infection Rates Are Eric J. Mao, Colleen R. Kelly, Jason T. 6283–6287 Attributable to Disparities in Health Care Access Machan How Robust Are Malaria Parasite Clearance Rates as Indicators Ian M. Hastings, Katherine Kay, 6428–6436 of Drug Effectiveness and Resistance? Eva Maria Hodel

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U.S.-Based National Sentinel Surveillance Study for the D. R. Snydman, L. A. McDermott, 6437–6443 Epidemiology of Clostridium difficile-Associated Diarrheal N. V. Jacobus, C. Thorpe, S. Stone, Isolates and Their Susceptibility to Fidaxomicin S. G. Jenkins, E. J. C. Goldstein, R. Patel, B. A. Forbes, S. Mirrett, S. Johnson, D. N. Gerding MALDI-TOF MS as a Tool To Detect a Nosocomial Outbreak of Nour Chems el Houda Khennouchi, 6477–6483 Extended-Spectrum-␤-Lactamase- and ArmA Lotfi Loucif, Nafissa Boutefnouchet, Methyltransferase-Producing Enterobacter cloacae Clinical Hamoudi Allag, Jean-Marc Rolain Isolates in Algeria Use of a Combination Biomarker Algorithm To Identify Medical Jennifer H. Han, Irving Nachamkin, 6494–6500 Intensive Care Unit Patients with Suspected Sepsis at Very Low Susan E. Coffin, Jeffrey S. Gerber, Barry Likelihood of Bacterial Infection Fuchs, Charles Garrigan, Xiaoyan Han, Warren B. Bilker, Jacqueleen Wise, Pam Tolomeo, Ebbing Lautenbach, for the Prevention Epicenters Program of the Centers for Disease Control and Prevention

Non-O1/Non-O139 Vibrio cholerae Avian Isolate from France Salim Aberkane, Fabrice Compain, 6594–6596

Cocarrying the blaVIM-1 and blaVIM-4 Genes Olivier Barraud, Abdoul-Salam Ouédraogo, Nicolas Bouzinbi, Marion Vittecoq, Hélène Jean-Pierre, Dominique Decré, Sylvain Godreuil Carriage of Escherichia coli Producing CTX-M-Type Extended- Thi Mai Huong Bui, Itaru Hirai, Shuhei 6611–6614 Spectrum ␤-Lactamase in Healthy Vietnamese Individuals Ueda, Thi Kim Ngan Bui, Kouta Hamamoto, Takehiko Toyosato, Danh Tuyen Le, Yoshimasa Yamamoto Antimicrobial Susceptibility Profiles of Staphylococcus aureus John J. Morelli, Patrick G. Hogan, 6634–6637 Isolates Recovered from Humans, Environmental Surfaces, and Melanie L. Sullivan, Carol E. Muenks, Companion Animals in Households of Children with Jeffrey W. Wang, Ryley M. Thompson, Community-Onset Methicillin-Resistant S. aureus Infections Carey-Ann D. Burnham, Stephanie A. Fritz Identification of NDM-1 in a Putatively Novel Acinetobacter Paula Espinal, Noraida Mosqueda, 6657–6660 Species (“NB14”) Closely Related to Acinetobacter pittii Murat Telli, Tanny van der Reijden, Dora Rolo, Dietmar Fernández-Orth, Lenie Dijkshoorn, Ignasi Roca, Jordi Vila EXPERIMENTAL THERAPEUTICS Concomitant Benznidazole and Suramin Chemotherapy in Mice Eliziária C. Santos, Rômulo D. Novaes, 5999–6006 Infected with a Virulent Strain of Trypanosoma cruzi Marli C. Cupertino, Daniel S. S. Bastos, Raphael C. Klein, Eduardo A. M. Silva, Juliana L. R. Fietto, André Talvani, Maria T. Bahia, Leandro L. Oliveira Effective Antibiofilm Polyketides against Staphylococcus aureus Terhi Oja, Paola San Martin Galindo, 6046–6052 from the Pyranonaphthoquinone Biosynthetic Pathways of Takaaki Taguchi, Suvi Manner, Pia M. Streptomyces Species Vuorela, Koji Ichinose, Mikko Metsä-Ketelä, Adyary Fallarero A Toll-Like Receptor 5 Agonist Improves the Efficacy of Rémi Porte, Delphine Fougeron, 6064–6072 Antibiotics in Treatment of Primary and Influenza Virus- Natalia Muñoz-Wolf, Julien Tabareau, Associated Pneumococcal Mouse Infections Anne-France Georgel, Fréderic Wallet, Christophe Paget, François Trottein, José A. Chabalgoity, Christophe Carnoy, Jean-Claude Sirard Antimicrobial Peptide Novicidin Synergizes with Rifampin, Odel Soren, Karoline Sidelmann 6233–6240 Ceftriaxone, and Ceftazidime against Antibiotic-Resistant Brinch, Dipesh Patel, Yingjun Liu, Enterobacteriaceae In Vitro Alexander Liu, Anthony Coates, Yanmin Hu

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In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor Pablo Winzer, Joachim Müller, Adriana 6361–6374 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma Aguado-Martínez, Mahbubur Rahman, gondii and Neospora caninum Vreni Balmer, Vera Manser, Luis Miguel Ortega-Mora, Kayode K. Ojo, Erkang Fan, Dustin J. Maly, Wesley C. Van Voorhis, Andrew Hemphill Antileishmanial Activity of Disulﬁram and Thiuram Disulﬁde Alex G. Peniche, Adam R. Renslo, 6463–6470 Analogs in an Ex Vivo Model System Is Selectively Enhanced by Peter C. Melby, Bruno L. Travi the Addition of Divalent Metal Ions Evaluation of Gallium Citrate Formulations against a Mitchell G. Thompson, Vu Truong-Le, 6484–6493 Multidrug-Resistant Strain of Klebsiella pneumoniae in a Yonas A. Alamneh, Chad C. Black, Jeff Murine Wound Model of Infection Anderl, Cary L. Honnold, Rebecca L. Pavlicek, Rania Abu-Taleb, Matthew C. Wise, Eric R. Hall, Eric J. Wagar, Eric Patzer, Daniel V. Zurawski In Vivo Pharmacodynamic Evaluation of an FtsZ Inhibitor, Alexander J. Lepak, Ajit Parhi, Michaela 6568–6574 TXA-709, and Its Active Metabolite, TXA-707, in a Murine Madison, Karen Marchillo, Jamie Neutropenic Thigh Infection Model VanHecker, David R. Andes

Antischistosomal Activity of Oxindolimine-Metal Complexes Josué de Moraes, Bruno S. Dario, 6648–6652 Ricardo A. A. Couto, Pedro L. S. Pinto, Ana M. da Costa Ferreira CLINICAL THERAPEUTICS Mucin Binding Reduces Colistin Antimicrobial Activity Johnny X. Huang, Mark A. T. 5925–5931 Blaskovich, Ruby Pelingon, Soumya Ramu, Angela Kavanagh, Alysha G. Elliott, Mark S. Butler, A. Bruce Montgomery, Matthew A. Cooper Pharmacokinetics and Safety of Ofloxacin in Children with Anthony J. Garcia-Prats, Heather R. 6073–6079 Drug-Resistant Tuberculosis Draper, Stephanie Thee, Kelly E. Dooley, Helen M. McIlleron, James A. Seddon, Lubbe Wiesner, Sandra Castel, H. Simon Schaaf, Anneke C. Hesseling Age-Stratified Treatment Response Rates in Hospitalized Vy P. Pham, Andrea M. Luce, Sara C. 6113–6116 Patients with Clostridium difficile Infection Treated with Ruppelt, Wenjing Wei, Samuel L. Metronidazole Aitken, William L. Musick, Ryan K. Roux, Kevin W. Garey Toxic Profile of Benznidazole in Patients with Chronic Chagas I. Molina, F. Salvador, A. 6125–6131 Disease: Risk Factors and Comparison of the Product from Two Sánchez-Montalvá, B. Treviño, N. Different Manufacturers Serre, A. Sao Avilés, B. Almirante Telavancin for Acute Bacterial Skin and Skin Structure Richard Pushkin, Steven L. Barriere, 6170–6174 Infections, a Post Hoc Analysis of the Phase 3 ATLAS Trials in Whedy Wang, G. Ralph Corey, Light of the 2013 FDA Guidance Martin E. Stryjewski Pharmacokinetics of Antituberculosis Drugs in HIV-Positive J. J. van Oosterhout, F. K. Dzinjalamala, 6175–6180 and HIV-Negative Adults in Malawi A. Dimba, D. Waterhouse, G. Davies, E. E. Zijlstra, M. E. Molyneux, E. M. Molyneux, S. Ward Exposure-Response Analyses for Tafenoquine after David Tenero, Justin A. Green, Navin 6188–6194 Administration to Patients with Plasmodium vivax Malaria Goyal Multicenter, Double-Blind, Randomized, Phase 2 Study Thomas Louie, Carl Erik Nord, 6266–6273 Evaluating the Novel Antibiotic Cadazolid in Patients with George H. Talbot, Mark Wilcox, Clostridium difficile Infection Dale N. Gerding, Martha Buitrago, Hilke Kracker, Pascal Charef, Oliver A. Cornely

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Persister Development by Borrelia burgdorferi Populations John R. Caskey, Monica E. Embers 6288–6295 In Vitro Amikacin Concentrations Predictive of Ototoxicity in Chawangwa Modongo, Jotam G. 6337–6343 Multidrug-Resistant Tuberculosis Patients Pasipanodya, Nicola M. Zetola, Scott M. Williams, Giorgio Sirugo, Tawanda Gumbo Antitrypanosomal Treatment with Benznidazole Is Superior to Shilpi Khare, Xianzhong Liu, Monique 6385–6394 Posaconazole Regimens in Mouse Models of Chagas Disease Stinson, Ianne Rivera, Todd Groessl, Tove Tuntland, Vince Yeh, Ben Wen, Valentina Molteni, Richard Glynne, Frantisek Supek Polymyxin B in Combination with Antimicrobials Lacking Maria Helena Rigatto, Fabiane J. Vieira, 6575–6580 In Vitro Activity versus Polymyxin B in Monotherapy in Laura C. Antochevis, Tainá F. Behle, Critically Ill Patients with Acinetobacter baumannii or Natane T. Lopes, Alexandre P. Zavascki Pseudomonas aeruginosa Infections Evaluation of Sulfobutylether-␤-Cyclodextrin Exposure in a Amanda A. Morris, Scott W. Mueller, 6653–6656 Critically Ill Patient Receiving Intravenous Posaconazole While Joseph E. Rower, Taylor Washburn, Undergoing Continuous Venovenous Hemoﬁltration Tyree H. Kiser PHARMACOLOGY Population Pharmacokinetics and Target Attainment of Mathias Wittau, Jan Scheele, Max 6241–6247 Meropenem in Plasma and Tissue of Morbidly Obese Patients Kurlbaum, Claas Brockschmidt, Anna M. after Laparoscopic Intraperitoneal Surgery Wolf, Evelyn Hemper, Doris Henne-Bruns, Jürgen B. Bulitta Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in Robert Bucki, Katarzyna Niemirowicz, 6274–6282 an Animal Model of Peritoneal Infection Urszula Wnorowska, Fitzroy J. Byﬁeld, Ewelina Piktel, Marzena Wa˛tek, Paul A. Janmey, Paul B. Savage Prospective Evaluation of a Model-Based Dosing Regimen for A. Smits, R. F. W. De Cock, K. 6344–6351 Amikacin in Preterm and Term Neonates in Clinical Practice Allegaert, S. Vanhaesebrouck, M. Danhof, C. A. J. Knibbe Lumefantrine and Desbutyl-Lumefantrine Population Frank Kloprogge, Rose McGready, 6375–6384 Pharmacokinetic-Pharmacodynamic Relationships in Pregnant Warunee Hanpithakpong, Daniel Women with Uncomplicated Plasmodium falciparum Malaria Blessborn, Nicholas P. J. Day, Nicholas J. on the Thailand-Myanmar Border White, François Nosten, Joel Tarning Altering Antimalarial Drug Regimens May Dramatically Katherine Kay, Eva Maria Hodel, Ian M. 6419–6427 Enhance and Restore Drug Effectiveness Hastings Population Pharmacokinetics of Fosfomycin in Critically Ill Suzanne L. Parker, Frantzeska 6471–6476 Patients Frantzeskaki, Steven C. Wallis, Chryssa Diakaki, Helen Giamarellou, Despoina Koulenti, Ilias Karaiskos, Jeffrey Lipman, George Dimopoulos, Jason A. Roberts Oritavancin Pharmacokinetics and Bone Penetration in Rabbits Dario Lehoux, Valerie Ostiguy, 6501–6505 Cordelia Cadieux, Mireille Malouin, Odette Belanger, Adel Rafai Far, Thomas R. Parr, Jr. Biopharmaceutical Characterization of Nebulized Antimicrobial Sandrine Marchand, Nicolas Grégoire, 6646–6647 Agents in Rats: 3. Tobramycin Julien Brillault, Isabelle Lamarche, Patrice Gobin, William Couet LETTERS TO THE EDITOR An Excision-Competent and Exogenous Mosaic Transposon Michael J. Calcutt, Mark F. Foecking 6665–6666 Harbors the tetM Gene in Multiple Mycoplasma hominis Lineages

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Complete Sequence of a blaNDM-1-Harboring Plasmid in an Marco Brovedan, Patricia M. 6667–6669 Acinetobacter bereziniae Clinical Strain Isolated in Argentina Marchiaro, Jorgelina Morán-Barrio, Marcela Cameranesi, Gabriela Cera, Mariángel Rinaudo, Alejandro M. Viale, Adriana S. Limansky First Report and Molecular Characterization of a Campylobacter Eunju Shin, Hyunjin Hong, Younghee 6670–6672 jejuni Isolate with Extensive Drug Resistance from a Travel- Oh, Yeonhee Lee Associated Human Case Minimizing Antibiotic Misuse through Evidence-Based Guillermo V. Sanchez, Katherine E. 6673 Management of Outpatient Acute Respiratory Infections Fleming-Dutra, Lauri A. Hicks Reply to “Minimizing Antibiotic Misuse through Evidence- Jennifer L. Schroeck, Christine A. Ruh, 6674 Based Management of Outpatient Acute Respiratory Infections” John A. Sellick, Jr., Michael C. Ott, Arun Mattappallil, Kari A. Mergenhagen ERRATUM Erratum for Jabes et al., Pharmacological Properties of NAI-603, Daniela Jabes, Cristina Brunati, 6675 a Well-Tolerated Semisynthetic Derivative of Ramoplanin GianPaolo Candiani, Simona Riva, Gabriella Romanó, Sonia Mafﬁoli, Rosaria Rossi, Matteo Simone, Eleonora Gaspari, Stefano Donadio

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