Excellence Seoul National University Hospital Biomedical Research Institute Vol.2 Seoul National University Hospital Excellence Biomedical Research Institute Vol.2

EXCELLENCE SEOUL NATIONAL UNIVERSITY HOSPITAL BIOMEDICAL RESEARCH INSTITUTE VOL.2 SEOUL NATIONAL UNIVERSITY HOSPITAL EXCELLENCE BIOMEDICAL RESEARCH INSTITUTE VOL.2

Contents Invitation 004 Organization 007 President Message 008 Laboratories & Research Centers 044 Research Statistics 108 Principal Investigators 122 Invitation

The Biomedical Research Institute

The Biomedical Research Institute began operations in 1978 with the objective of improving clinical quality with 24 labs and 20 animal experiment rooms covering 2,049m2 at the offices of the 12th and 13th floors of SNUH. To facilitate the institute’s increasing role as a leading hospital-affiliated research center, construction of a separate building was planned in 1989. A building was completed after three years of construction on May 15, 1998, with a floor area of 22,277m2 and 11 floors above ground and one basement floor.

Biomedical research Clinical research essential to national practices related to public policy biomedicine

Center for Medical Innovation(CMI) After 10 years of preparation, the Center for Medical Innovation(CMI) opened on July 16, 2015, as a joint and early-stage medical research facility focusing on the innovation and fusion of industry, academia, research institutes and hospital R&D processes. Construction of the institute began in May 2012 at a combined cost of KRW 62.3 billion. The building has four above-ground floors and five Promotion of basement-level floors with a gross floor area of 31,261m2. professional Connection to research basic sciences personnel The institute’s key feature is innovative and organic collaboration of industries, universities, think tanks and hospitals. Most studies, research, commissions, clinical trials, commercialization and other functions of think tanks had been operated independently, but the institute is designed to break down barriers between and unite the pharmaceutical industry, academia, think tanks and hospitals to create a more efficient, complementary and horizontal network with the goal of “developing new products for patient care.”

As such, if the existing processes at think tanks were to perform clinical research at hospitals to develop new drug candidates by seeking sponsorships from pharmaceutical companies, the institute integrated this brokered research process by enabling active participation from every contributing Development of Clinical testing and verification member. This allowed the practice of curing diseases through the development of clinical medicine to potential medicinal of newly developed medicines be more efficient from beginning to end. candidates and medical devices Organization

IRB President, SNUH IACUC

IBC Mission President, SNUH ----- Biomedical Research Institute To improve the health of human Planning & Operation beings through outstanding Committee biomedical research Headquarters of Research Administration and Coordination

Division of Technology Division of Research Licensing Office Partnership

Division of IT & Database Division of Public Affairs

Division of Clinical Division Of Manpower Bioinformatics Training

Administrative Office

Center for human Medical Research Vision research protection Collaborating Center ----- QA Office Division of Biostatistics Supporting Division of Global top 10 biomedical Office For Irb Clinical Epidemiology research institutes in 2020 Education and Division of Clinical Data Regulatory Office Management

Clinical Translational Medical Device Trials Center Research Institute Innovation Center

Division of Laboratory Safety SNUH Biobank Vice Director Division of Medical Medical Device Device R&D Usability Testing Support Global Strategic Cancer Human Brain Planning Tissue Bank Biobank Bank Premium Endoscope Medical Imaging Development QI Office Administrative Office Equipment Collaboration Core Values Research -----

Collaboration & Division of Division of Division of PK/PD Division of Department of Department of Department of Experimental Animal Research General Cancer Pediatric Lab Education and Transdisciplinary Research Research & Experiment Clinical Trials Clinical Trials Clinical Trials Training and Collaboration Convergence·Originality· Division of Experimental Animal Research Biomarker Center Central Research Reliability·Excellence Laboratory Division of Nonhuman Primate Research Division of Transdisciplinary Collaboration Division of Good Laboratory Practice Core Facility Division of Transdisciplinary Research Division of Medical Device Evaluation

Design Studio/Machine Research Supporting Experimental Animal Research Imaging Center Shop Management Office Vol.2 Vol.2

Excellence Excellence 7 President Message

As Korea’s leading medical institution, Seoul National University Hospital has achieved remarkable growth since the establishment of its modern healthcare systems. The predecessor of the Biomedical Research Institute, the Clinical Research Institute, was opened in 1998, and we have strived to advance Korean medicine with the goal of taking on the world stage.

The hospital built the Center for Medical Innovation in July 2015 as an R&D facility to bring about the convergence of the medical industry, universities and hospitals to create an open innovation platform for the sake of achieving cutting-edge breakthroughs.

Through these developments, the Biomedical Research Institute(BRI) at Seoul National University became Korea’s first medical institution to publish over 1,000 papers in academic journals registered in the SCI in a single year, and the first university hospital to qualify as a global think tank by meeting the criteria for Good Laboratory Practice(GLP) standards and obtaining the full approval of the Association for Assessment and Accreditation of Laboratory Animal Care(AAALAC).

With a research budget of 120 billion KRW and publication of over 2,500 papers in 8 academic journals registered in the SCI, our hospital has developed an advanced project for cell therapy treatment and a range of other national projects. We were also appointed a research center by the Ministry of Health and Welfare in 2013 and Asia’s first hospital to perform clinical testing and research.

Seoul National University Hospital has opened the door to new possibilities in Korean medical research by focusing on the creation of an international bio-cluster through the BRI. We will keep striving to become the world’s best research-oriented hospital through our excellent medical staff and facilities and efficient application of our abundant clinical resources.

Suh, Chang Suk President & CEO

Seoul National University Hospital Professor | Laboratories & Research Centers | Research Statistics M.D., Ph.D.

Jue

Yung

For years, Seoul National University Hospital(SNUH) has been on the University Hospital(SNUH) has For years, Seoul National innovation to clinical practice, dramatically line of bringing medical front Behind this leadership has health in this country. advancing the public community of research effort by the excellent always been a concerted of an outstanding and translational investigators SNUH, served by clinical Institute has Biomedical Research Since established in 1991, the caliber. leadership at SNUH. of this research been sitting in the center by the government the designation The two most notable examples are Trials in Clinical first Global Center of Excellence for SNUH as the nation’s Opening of the Center for Hospital in 2013. in 2012 and Research-Driven welcomed addition to this eminent Medical Innovation in 2015 is another of long-standing leadership of SNUH, which is the culmination research by SNUH shared mentality, belief for open collaboration and anti-silo most optimal the will continuously strive for providing investigators. We but also for outside ecosystem, not only for SNUH investigators, research collaborators. that discoveries This will certainly lead to a series of breakthrough us in Please join globally. our patients ultimately change the way we treat this exciting journey. Bang, President, Biomedical Research Institute 11 Clinical Director Trials Center

Vice Global strategy and planning Director

Seoul National University Hospital Clinical Trials Center(SNUH CTC) was established in 1995 as Korea’s first specialized medical body. SNUH CTC has QI Office Administrative office performed clinical trials over the past 20 years. Since its establishment, the center has strengthened its infrastructure to boast the best research facilities in Korea as well as the country’s best researchers in the field. In December 2004, SNUH CTC was designated as the first regional clinical trials center by the Ministry of Health and Welfare(now MFDS), and in 2012, it was named a global Division of Division Division of PK/PD Lab Division of center of excellence in early clinical trials. These accolades made it possible for Clinical Trials of Cancer Pediatric Education Clinical Trials Clinical Trials and Training the center to expand in size and quality. The number of trials conducted at the Office center is rapidly increasing based on the related infrastructure, and the SNUH CTC works in close collaboration with other think tanks and pharmaceutical companies in and out of Korea. The center is conducting more than 253 clinical trials(as of 2015) and has played a leading role in the clinical trials of newly developed medicines in Korea.

Facilities for clinical trials • Research wards(52 beds : 42 inpatient, 10 daycare/injection room) • 7 outpatient clinics • 2 pharmacies(Main and oncology) • 2 core labs, labs for cardiopulmonary function testing, analytical chemical, pharmacoepidemiology and PK/PDMedical device research lab • Data archives Bang, Yung Jue Vol.2 Vol.2 • Monitoring rooms(29 seats at main center, 5 rooms at Oncology CTC) Director, SNUH CTC 12

Excellence Excellence 13 Members of Clinical Trials Center

Bang, Yung Jue Director, SNUH CTC Jang In Jin Vice Director, SNUH CTC Lee, Howard Head, Global Strategy & planning Lee, Hae Young Head, Division of General Clinical Trials Kim, Dong Wan Head, Division of Cancer Clinical Trials Kim, Han Suk Head, Division of Pediatric Clinical Trials Yu, Kyung Sang Head, PK/PD Lab Yim, Jae Joon Head, Division of Education & Training Cho, Jeong Yeon Head, Quality Improvement Kim, Sunyoung Head Nurse, Clinical Research Ward Baik, Jung Mi Head Nurse, Oncology Clinical Research Ward Jang, Hong Won Chief Pharmacist, CTC Pharmacy Lee, Keun Ja Senior Manager, CTC Administrative Office

Keynote of SNUH CTC SNUH CTC has developed its own SOP(standard operating procedures) in accordance with ICH-GCP and other international guidelines. They are regularly being modified and supplemented. The center is also constantly upgrading the quality of research through clinical trial-related education and training programs. The CTC is annexed to SNUH, which allows rapid patient recruitment from diverse medical departments. Using EPICS(Early Phase Integrated Clinic Automation Solution), research efficiency and accuracy are maximized. In 2007, SNUH CTC was designated an implementation institution for medical device clinical trials by the Korea Food and Drug Administration(now MFDS), and this led to the establishment of the Medical Device Usability Testing Center. This center conducts clinical studies on medical devices and provides education to researchers about such devices.

Future plan Due to the rising number of clinical trials performed at SNUH CTC, an expansion plan was set up to secure more space and facilities. The main CTC space will be doubled by adding another floor exclusively for clinical trials(fourth floor). The specifics of the expansion plan are as follows : • 102 inpatient beds(80 fully monitored) • 34 monitoring rooms th • 4 floor devoted to general research ward Jang, In Jin Vol.2 Vol.2 • Spacious pharmacy and core lab Vice Director, SNUH CTC 14

Excellence Excellence 15 Department of Translational Translational Department of Department of Transdisciplinary Research & Experimental Research Research and Experiment Animal Research Research Institute Institute Collaboration

Cancer Tissue Bank

Established in January 2014, the Translational Research Institute at Seoul SNUH Human Biobank National University Hospital(SNUH) is comprised of independently operated Biobank affiliates, namely the Department of Research and Experiments, Department Brain Bank of Experimental Animal Research and the newly established Department of Transdisciplinary Research and Collaboration and SNUH Biobank. The institute serves as an intermediary(translational) think tank that analyzes and interprets observational data results in real time so that the results can be immediately applied to the implementation and testing phase of the research development Division of process. Laboratory Safety

Member of Translational Research Institute

Park, Kyong Soo Director, Translational Research Institute Oh, Seung Ha Director, Department of Research & Experiment Yu, Hyeong Gon Director, Department of Experimental Animal Research Seong, Moon Woo Director, Department of Transdisciplinary Research and collaboration Park, Kyong Soo Director, Biobank Kang, Ji Young Director, Division of Laboratory Safety

Park, Kyong Soo Vol.2 Vol.2 Director, Translational Research Institute 16

Excellence Excellence 17 Department of Research & Experiment

The Department of Research and Experiments is one of the main departments supporting in-vitro research at Translational Research Institute(TRI), mainly consisting of shared facilities, nine core facilities, a central research laboratory and a TRI administrative office. The department takes up five floors(covering 18,000 square meters) of the Center for Medical Innovation(CMI), and research professors’ office, cell culture and freezer rooms, core and shared facilities, multiple meeting rooms, 307 wet benches and 127 dry research desks are adequately arranged on each floor. Around 450 clinical researchers with dozens of research-assisting specialists and clinical studies professors are putting concerted efforts toward forming a systematic research environment and activating clinical research. Accessibility to cutting-edge research equipment and application of the latest clinical research-related infrastructure to experiments are much easier in this department via core facilities: flow cytometry, proteomics, analytic chemistry, pathology, microbiology, radioisotope, culture media and supplements, tissue and serum bank, and confocal core facility, and over 900 shared facilities. We also support groups performing national research projects at Seoul National University Hospital, Innovative Cell Therapy Research Cluster and Research Support Center for Rare Disease. Moreover, we annually allocate lab benches, paper research desks, research professors’ offices and individual open space for personal research instruments pursuant to the regulation of Biomedical Research Institute (BRI) to users and new applicants. Any need in research at CMI is immediately reflected in research supporting policies in our department, and the researchers’ demand for new technology is fully satisfied by a biannual workshop on research experimental methods on up-to-date research information and introduces high- tech analyzers. Like these, we are doing our best to support and provide optimal space and a comfortable research environment for experiments, field-related cutting-edge technology, specialized data for analyzing service, continuing education and operation of multiple core facilities for researchers to achieve success in clinical research and contribute to human health.

Members of Department of Research & Experiment

Oh, Seung Ha Director, Department of Research & Experiment Kim, Dong Ki Chief, Central Research Laboratory Oh, Seung Ha Director, Department of Research & Experiment Vol.2 Vol.2

Excellence Excellence 19 Department of Experimental Animal Research

The Department of Experimental Animal Research(DEAR) consists of five units: Members of Department of Division of Experimental Animal Research(DEAR), Division Good Laboratory Experimental Animal Research Practice(GLP), Division of Medical Device Evaluation(MDEC), Nonhuman Yu, Hyeong Gon Director, Department of Experimental Animal Research Primate Research Center(NPRC) and Magnetic Resonance Research Center Lee, Sahng Hoon Chief, Division of Experimental Animal Research (MRRC). Kwon, Oh Sang Chief, Division of Nonhuman Primate Research(NPR) DEAR consists of an animal lab facility housing specific pathogen-free(SPF) Choi, Eue Keun Chief, Division of Medical Device Evaluation rodents, rabbits, dogs, goats, pigs and cats. DEAR has specific lab facilities Jung, Chul Woo Chief, Division of Good Laboratory Practice(GLP) including operating rooms for surgery, intensive care unit(ICU), clinical pathology, Kim, Hyeon Jin Chief, Experimental Animal Research Imaging Chief, 10th floor of Experimental Animal Research imaging diagnosis(radiology and ultrasonography), soundproof room and Kang, Byeong Cheol biosafety level 3 facility. DEAR plays a major role to support animal research. GLP and MDEC fulfill non-clinical studies(toxicity, efficacy and biocompatibility) on drugs, functional food ingredients, cosmetics, biologics and medical devices according to GLP regulations. NPRC consists of a nonhuman primate facility and specific lab for nonhuman primates. MRRC operates state-of-the-art small animal MR equipment(Agilent, 9.4T) since 2012, and provides application of MRI and MRS methodology in biomedical research for new medicine development, disease diagnosis method and treatment method development. In 2013, DEAR underwent inspection and was fully third accredited by the AAALAC for improving animal management and global animal care system. All animal protocols should be reviewed and approved by the Institutional Animal Care and Use Committee(IACUC) at Seoul National University Hospital. DEAR also provides an education course on basic animal experiment techniques and Yu, Hyeong Gon standard operating procedure to ensure efficient conduct in animal experiments. Director, Department of Vol.2 Vol.2 Experimental Animal Research 20

Excellence Excellence 21 Biomarker Center Department of Transdisciplinary Genomic & proteomic Biomarker Discovery Members of Biomarker Center

Medical & Proteomic Genomic Big Data Chae, Jong Hee Director, Biomarker Center Clinical Research Analysis Research and Collaboration Research Proteomics Core Facility Research Han, Do hyun Lee, Hyun Seob Gemomics Core Facility

The Department of Transdisciplinary Research and Collaboration consists Biomarker Center of the Biomarker Center and three divisions: Genomics Core Facility, - Proteomics Core Facility and Design Studio/Machine Shop. We provide We aim to provide the best research collaborative support for multidisciplinary research in close coordination platforms for the discovery of disease- with the clinical bioinformatics team and other research departments. The related biomarkers and development Genomics Core Facility’s instruments for genomic research include a nucleic of a diagnostic system through acid purification system and validation system, droplet digital PCR, real- advanced infrastructure(research Time PCR and sequencing machine, and provide cutting-edge genomic facility), human resources and services to researchers. The Proteomic Core Facility provide state-of-the- research funding for multiple Omics art LC-MS/MS analysis including protein identification, proteome profiling, analysis of basic and intermediate protein quantification and post-translational modification analysis in various clinical studies based on precision medicine to researchers. The Biomarker samples for researchers. The Design Studio/Machine Shop equips 3-D Center consists of the Genomics Core Facility(GCF), which focuses on the study printing facilities such as high-resolution 3-D and metal printers as well of genomic, transcriptomic and epigenetic mechanisms and the Proteomics Core as general machinery tools, and 3-D printing related services such as 3-D Facility(PCF) for proteomic research. scan, 3-D printing, medical image processing and product design support The GCF’s mission is to facilitate cutting-edge genomics technologies for are immediately provided for materializing an idea to a prototype. Our researchers. The facility houses and implements state-of-the art instruments, department is located on the second floor [2208-2, 2208-3] and the third including Agilent 2100 Bioanalyzer, Agilent 2200 TapeStation, Droplet basement floor [B3303] of the CMI building. Digital PCR and real-time PCR machines. We also plan to provide the next- generation sequencing(NGS) platforms(Covaris focused-ultrasonicator, Bravo automated library prep system and Illumina NextSeq 500 systems) and the Genome editing system(CRISPR/Cas9 system) platform for research on the functional mechanisms of novel variants in various genetic diseases. The PCF’s mission is to advance next-generation proteomic technologies, apply them to timely questions in basic, translational and clinical research, and develop biomarkers for various diseases with researchers at Seoul National University Hospital(SNUH) and SNU. We provide state-of-the-art LC-MS/MS analysis including protein identification, proteome profiling, in-depth protein quantification, post-translational modification analysis and targeted proteomic analysis in various clinical samples for researchers in and out of SNUH.

Seong, Moon Woo Director, Department of Transdisciplinary Chae, Jong Hee Vol.2 Vol.2 Research and Collaboration Director, Biomarker Center

Excellence Excellence 23 SNUH Biobank

Members of SHUN Biobank

Park, Kyong Soo Director, Biobank Park, Sung Sup Director, Human Biobank Kim, Woo Ho Director, Cancer Tissue Bank Wang, Kyu Chang Director, Brain Bank

SNUH Biobank is comprised of the Human Biobank, Cancer Tissue Bank and Brain Bank. The first two banks follow accepted standards and guidelines on bioethics and safety in the collection, storage and management of human biological materials and clinical data for continuing R&D. The Human Biobank collects fresh tissue, bodily fluids, blood and other biological materials. The Cancer Tissue Bank collects fresh tissue, Methacarn block and other biological materials. The Brain Bank provides accurate diagnoses using the brain, blood, and cerebrospinal and other biological fluids attained from the body and systematically combines the findings with existing clinical data. The resources stored at the biobank are objectively reviewed and distributed to researchers, and considered to be invaluable to the development of medical and life Park, Kyong Soo Vol.2 Vol.2 sciences. Director, SNUH Biobank 24

Excellence Excellence 25 Human Biobank - Since being selected as a regional Biobank in 2010, SNUH Biobank has been Department of Prescription active as a participating organization of the KBN. SNUH Biobank collects and for Specimen stores human bio-resources from patients in a fresh state such as blood and Planning Taking bodily fluids. A monitoring and security system helps the non-stop real-time maintenance of a stable storage temperature for frozen human bio-specimens. Loss of bio-specimens is prevented, and stored bio-specimens are distributed to researchers through a fair assessment process. In this way, the Biobank aims to contribute to the development of health and medicine and advancement of the medical industry.

Laboratory Medicine : EMR Data Automatic Resources Gathering Transmission

Biobank CRC : Members of Human Biobank Park, Sung Sup Consent from receipt Park, Sung Sup Director, Human Biobank Kim, Dong Ki SNUH-HuB, Biobank Information Kwon, Ki Chang Management System(BIMS) Lee, Hyun Jung Lee, Jae Eun Won, Mi Ran Park, Seul Ki

Korea Researcher, SNUH Biospecimen laboratory, Research Network(KCDC) company Network Vol.2 Vol.2

Excellence Excellence 27 Cancer Tissue Bank Brain Bank - - Cancer Tissue Bank is responsible for collection and storage of tissue Seoul National University Hospital Brain Bank(SNUHBB) was established in July resources, clinical information management and distribution to researchers. 2015 to boost research on brain diseases and neuroscience in Korea. Its aims It performs excision of tissues on areas not affected by diagnosis results. are to collect and store human brain tissue donated by healthy people as well Tissue collected by this bank are kept at storage facilities with extremely low as patients with neurological or psychiatric disorders and distribute the brain temperatures such as a liquid nitrogen tank(-196℃), whose temperature is tissue and anonymized related clinical information to scientific researchers. With monitored 24 hours a day, to ensure the best quality of stored tissue. Each of an increased life expectancy and an ageing population, neurological, psychiatric tissues(normal or tumor, 0.3g) is contained in a sterilized cryovial labeled with and neurodegenerative diseases are a major health problem and produce a number for personal data anonymity. Before distribution, part of the stored heavy socio-economic burden, worldwide, which include Alzheimer’s disease, tissues is made into a frozen section slide and then stained by H&E. Morphology Parkinson’s disease, dementia with Lewy bodies, progressive supranuclear of an H&E slide is reviewed by a pathologist to confirm tumor volume. Through palsy, multiple system atrophy. It has never been more important to carry out tumor volume, the selected tissues are measured to see if they are appropriate the research to solve nervous system diseases. Only from basic and clinical specimens for research. The integrity test of RNA and DNA on frozen tissue is research, we can understand the cause and pathomechanism of diseases of used for quality control and regularly conducted. Conducting quality control the brain, develop effective treatments and prevent or reduce such diseases. Kim, Woo Ho tests if storage conditions and processing methods are adequate and keep SNUHBB does the efforts to provide clinically and neuropatholgically well- stored tissue good. characterized human brain tissue on which the scientists and medical doctors Director, Cancer Tissue Bank Cancer Tissue Bank ethically and fairly provides researchers with collected can conduct valuable research in their fields of expertise. SNUHBB is the first human tissue and clinical data for high quality results. hub brain bank funded by Korean government(the Ministry of Science, ICT and Future Planning).

Members of Brain Bank

Wang, Kyu Chang Kim, Ee Kyung Park, Sung Hye Park, Chan Wook Park, Chul Kee Members of Cancer Tissue Bank Sung, Jung Joon Won, Jae Kyung

Kim, Woo Ho Lee, Dong Young

Kim, Min A Jeon, Beom Seok Choi, Seung Hong Hong, Youn Ho Choe, Ghee Young Kim, Ji Eun Kim, Sang Yun Kang, Seong Sil Yun, Ye Lin

Wang, Kyu Chang Vol.2 Vol.2 Director, Brain Bank 28

Excellence Excellence 29 Committee, such as mandatory vaccination for the research. The Division of Division of Laboratory Safety, together with the Division of Safe Hygiene Management and Emergency Room, sets up a comprehensive safety system by managing not only bio-safety but also everything related to lab safety like fire protection, Laboratory Safety chemistry, electricity, health and equipment. The goal of the Division of Laboratory Safety is to ensure a safe research environment and support for the BRI to get the results of its research globally acknowledged.

Lab safety is one of the primary aspects required prior to science and research. Aroundeight Korean ministries such as the Ministry of Science, ICT and Future Planning, Korea Centers for Disease Control and Prevention, Ministry of Environment and Ministry of Food and Drug Safety enact laws and regulations on laboratory safety and related aspects. The Biomedical Research Institute(BRI) of SNUH built and remodeled the Center for Medical Innovation(CMI) in 2015 to achieve advanced medical research of a new era and established the Division of Laboratory Safety under immediate control of the CMI manager to generalize lab safety managed separately by every division. Members of The Division of Laboratory Safety is staffed by a biological safety specialist Laboratory Safety with a Ph.D and an industrial safety and fire protection officer, so that the safety Kang, Ji Young Biological safety specialist system of the BRI is technical and efficient. Kim, Seong Hoon Fire protection and SNUH has the nation’s largest animal research facility including that for industrial safety officer primates, as well as a Bio-Safety Level 2 and Bio-Safety Level 3 that can effectively research selected agents, so lab safety is crucial to advanced research and treatment of new infectious diseases. On the basis of specialized management by 11 deliberating committee members, the Institutional Biosafety Committee(IBC), an important factor in biosafety, secures and ensures safe and reliable research by letting experiments about LMO, or pathogens also over Bio-safety Level 2, proceed after a risk assessment through pre-review. The IBC deliberates yearly on about 50 agenda items of the board by closely communicating with the Institutional Animal Care and Use Committees(IACUC), Institutional Review Board(IRB) and Infection Control Committee. In addition, the committee plays the a role of pathfinder and contributes to Korea’s bio-safety by training the administrator. The Division of Laboratory Safety sets up a specialized and effective safety training system for SNUH researchers such as safety training for new researchers, hazardous materials and bio-safety. It also constructs a special facility and monitoring system for Bio-safety Level 2 and 3 designed for safety and a systematic safe environment through training and inspection. Physical examination before disposition of all researchers and regular checkups are essential, as well as professional health management jointly with the Division of Infection Control and Cardiopulmonary Resuscitation(CPR) Vol.2 Vol.2

Excellence Excellence 31 Medical Device Medical Device Innovation Center

Division of Division of Division of Division of Endoscope Medical Device Medical Device Premium Medical Innovation Center Equipments Development Usability Testing R&D Support Research Collaboration

Medical Device Innovation Center(MDIC) is originated from Division of Division of Medical Device Usability Testing : For medical devices, the most Medical Device Clinical Trials(DMDCT), a part of the Clinical Trials Center important goal of the usability test is to minimize user-related hazards and (CTC), created in 2007. Between 2008 and early 2013, SNUH acquired to find the most effective and safest methods for device users. To meet the governmental fund from Ministry of Health and Welfare(MHW) to establish international standard for medical electronic equipment, compliance to the 3rd the infrastructure for connecting clinical trials site with medical device version of IEC 60601-1 became mandatory. In early 2015, the SNUH DMDCT manufacturers and research institute to foster medical device development acquired a total funding of more than half million dollars(US) for a period of 3 within Korea. DMDCT had been externally called as Medical Device years with a project of the ‘Medical Device Usability Infrastructure Building’ from Clinical Trial Center. Professor Seung-June Oh has been the Director the MHW to establish UTC. Currently, SNUH UTC is the first and the only test of DMDCT(MDCTC) since April 2013. The research activities as well as center built in Korea. The SNUH UTC provides usability test service based on administrative work had rapidly increased. In 2016, the DMDCT was the excellent clinical resources and infrastructure of SNUH to support domestic separated from CTC and became independent organization with achieving medical device companies to enter the global market. the second round of competitive grant of 4.3 million dollars(US) for the period of five years from MHW in late 2015. From Aug 2016, DMDCT was Division of Medical Device R&D Support : Its mission is to introduce up-to- renamed as the Medical Device Innovation Center(MDIC). Currently, MDIC is date information on the new technologies to the medical device researchers in comprised of four major divisions. the SNUH to promote medical device R&D. It also aims to commercialize the useful ideas from clinicians of different areas. In addition, it helps researchers to make use of the extramural funding sources.

Division Premium Medical Equipment Research (PREMIER) : The Department Oh, Seung June of Radiology of the SNUH is a world-renowned center of excellency equipped with the highest research capability. The MDIC acquired 4.3 million dollars(US) in Director, Medical Device Innovation Center late 2015 for the period of a total of five years from MHW, as afore-mentioned, to build an infrastructure specialized for world-class medical imaging devices.

Division of Endoscope Development Collaboration : Endoscopic procedures Members of are very widely used in almost every medical field as minimally invasive Medical Device techniques are being permeated. Korea Electrotechnology Research Innovation Center Number of Medical Device clinical trials in SNUH Institute(KERI) has been performing research on optics and electronic imaging

IIT(Investigator Initiated Trials) SIT(Sponsor Initiated Trials) processing area for quite length of time. Endoscope Development Collaboration Oh, Seung June Director, Division of Medical division was formed out of a few times of mutual visits and collaboration Device Clinical Trials 12 Jeong, Chul Woo Chief, SNUH Usability 13 22 between SNUH and KERI since 2013. Following this, SNUH established MOU 15 Testing Center 22 with KERI in April 2014 and has been committed to developing endoscope 33 Lee, Jung Chan Chief, Division of Medical 23 27 system along with KERI. Final goal of these joint efforts is the commercialization 10 20 Device R&D Support of cutting-edge endoscope system. Park, Sang Joon Chief, Division of Premium 2011 2012 2013 2014 2015 Medical Imaging Equipment Research Jeong, Chang Wook Chief, Division of Vol.2 Vol.2 Endoscope Development Collaboration

Excellence Excellence 33 Members of Headquarters of Research Headquarters of Research Administration and Coordination Kim, Hee Chan Director, Headquarters of Research Administration and Coordination and Chief, Division of Administration and Technology Licensing Office Choy, Young Bin Chief, Division of IT & Database Yoon, Hyung Jin Chief, Division of Clinical Bioinformatics Jeong, Chang Wook Chief, Division of Research Partnership Coordination Moon, Hyeong Gon Chief, Division of Public Affairs Lee, Hae Young Chief, Division of Manpower Training Jung, Wun Soep Chief, Administrative Office

The Headquarters of Research Administration and Coordination is tasked with supporting medical research by developing progressive policies, providing financial management and coordinating research personnel and operations. This is Kim, Hee Chan accomplished through the divisions of research planning and development, public Director, Headquarters of Research Administration and affairs, research support, IT and database, and administration. The department is Coordination the center of the institute’s division of Technology Licensing Office, division of IT & Database, division of Clinical Bioinformatics, division of Research Partnership, division of Public Affairs, division of Manpower Training and Administrative support.

Division of Technology Division of Licensing Office Research Partnership

Headquarters Division of of Research Public Affairs Division of IT & Database Administration and Division of Coordination Manpower Training

Division of Clinical Administrative Office Bioinformatics

• Formulation of mid- to long-term plans for research • Financial management and service procurement for research • Statistical analysis and publishing of research data • Budgeting and management of research resources • Administrative support for all departments related to biomedical research • Providing public relations and education programs for research • Administrative support for inventors and their inventions • Appointment of research personnel and human resource management Vol.2 Vol.2 • Management of all administrative affairs and operations 34

Excellence Excellence 35 Technology Technology Management of Utilization of Support for Licensing IP IP startups Licensing Office Office

IP Creating IP Sales/ Venture In 2011, the Technology Licensing Office(TLO) was opened to provide Marketing Incubating intellectual property(IP) management services to leverage and enhance the utility of Seoul National University Hospital’s IP assets. The office is not only responsible for industrial property rights including utility, design and trademarks, but also the entire process of systematically collecting, evaluating, assigning, transferring, protecting and post-transaction management handling of a growing range of biotechnology assets, including advanced industrial property rights, computer programming, copyrights, and information property rights. The ultimate goal of the TLO is to enable the hospital to become Korea's top research hospital by creating a new profit model for the hospital’s investments and promoting awareness of IP assets that enhance and contribute to the hospital's core capabilities and its people.

Kim, Hee Chan Chief, Technology Licensing Office Vol.2 Vol.2

Excellence Excellence 37 Genomics & Epigenomics Data, Big Data Medical & Clinical Data, Division of Clinical analyses Health Care Data Bioinformatics

CBI Analysis pipeline, Web-based Data mining technique, service Source code The Division of Clinical Bioinformatics(CBI) is a hub for the integrated data analysis of SNUH researchers. It collects and archives dispersed data from a variety of sources and provides internal and external data and analysis Database compilation solutions to researchers. In the long run, CBI will allow comprehensive patient data analysis by compiling not only genomics data but by also collecting clinical, healthcare and image data, and provide web-based resources for mining multi-omics and multi-platform data. CBI is setting up databases and

analysis pipelines for genomics, transcriptomics and epigenomics research. SNUH database, Furthermore, analysis consultation and custom analysis services for biomedical Commercial database, big data are provided. Open Public database

Members of Division of Clinical Bioinformatics

Yoon, Hyung Jin Kim, Kwang Soo

Yoon, Hyung Jin Chief, Division of Clinical Bioinformatics Vol.2 Vol.2

Excellence Excellence 39 Medical Research Function Research services in statistical methodology and data Coordinating Multicenter studies management and bridging between basic- Collaborating Center(MRCC) medical research teams

Research services Research Coordination The Medical Research Collaborating Center(MRCC) seeks to provide high- quality research services and education and serve as a coordinating center for large-scale multicenter clinical trials and epidemiologic studies. It consists of the Division of Biostatistics, Division of Data Management and Division of Clinical Epidemiology. MRCC Pre-review The MRCC collaborates in all aspects of the study design, data management of IRB and statistical analysis of clinical, epidemiological, and lab research data. Protocols Consulting The divisions of clinical epidemiology and biostatistics provide consultative services from the initial design stage to the final reporting phase of clinical research. Data Management provides reliable and efficient data management. It has Pre-review of study Education PhactaX(self-developed), iCReaT(developed by the Centers for Disease protocol by statisticians Consulting for clinical and research nurses Control and Prevention) and Promasys, which is made in the Netherlands and research from design to final reporting stage used internationally as a data management system. The MRCC offers courses on the methodology involved in medical research each year to help medical investigators acquire basic knowledge for performing Providing education programs in medical medical research. Also, training programs strive to develop experts in clinical research methodology epidemiology, biostatistics and data management, who will lead the country in building domestic infrastructure. We routinely perform scientific pre-reviews of study protocols of IIT(investigator- initiated trial) conducted at Seoul National University College of Medicine or Seoul National University Hospital for supporting IRB function.

Members of Medical Research Collaborating Center(MRCC)

Kang, Hyun Jae Director, Medical Research Collaborating Center Kang, Hyun Jae Lee, Joong Yub Chief, Division of Clinical Epidemiology Director, Medical Research Vol.2 Vol.2 Hahn, Seo Kyung Chief, Division Of Biostatistics Collaborating Center 40

Excellence Excellence 41 Center for Human CHRP IRB Research Protection(CHRP) Administration

Center for Human Research Protection(hereafter CHRP) was established in Quality Compliance May 2011 with a mission to protect the rights and welfare of human research Assurance Assistance subjects and create a culture of highly standardized ethical research. CHRP is mainly responsible for the effective operation of Human Research Protection Program(hereafter HRPP), an integrated quality management program to protect the rights and wellbeing of human subjects who participate in research projects. CHRP consists of three divisions of IRB Administration, Quality Assurance, and Compliance Assistance. The division of IRB Administration Members of Center for manages and supports that the IRB of Seoul National University College of Human Research Protection(CHRP) Medicine and Seoul National University Hospital can scientifically and ethically Director, Center for Human Research Protection review research protocols. The main duty of the division of Quality Assurance is Kim, Ock Joo Park, Heung Woo Officer, Division of IRB Administration in CHRP to perform internal audits to oversee that research is conducted in accordance Suh, Dong In Officer, Division of QA in CHRP with protocol and regulations. The division of Compliance Assistance manages Kim, Jeong Hun Officer, Division of Compliance Assistance in CHRP HRPP policies and provides educations for clinical researchers and IRB members.

Kim, Ock Joo Director, Center for Human Vol.2 Vol.2 Research Protection 42

Excellence Excellence 43 Seoul National University Hospital Biomedical Research Institute & Vol.2 Vol.2

Excellence Excellence 45 Sensory Organ Research Center Members of Sensory Organ Brain Plasticity with Hearing Loss : Research Center Disapperance of contralateral dominancy after single-sided deafness in auditory cortex of adult rats

We perform research on auditory and Principal Investigator vestibulocochlear organs involving Seung ha Oh hearing loss(unilateral/bilateral), Professor Jun Ho Lee, Moo Kyun Park, tinnitus and dizziness. Myung Whan Suh We also develop clinical methods for Researcher the objective diagnoses and treatm- Jae Joon Han, Ji hye Rhee, Jeong-Sug ents using pure tone audiometry, tinni- Kyon, Young mi Yu, Tae Soo Noh, Yu jung togram, auditory brainstem response Hwang, Jeong Ah Cho, Doo Hee Kim, So or rotation chair test. A repetitive transcranial magnetic stimulation therapy is Hyeon Park, Na Hyun Kim used for reducing pain from tinnitus and cochlear implantation is suggested for the hearing impaired. We are also developing a clinical device for the objective The change of the peak amplitude of neural activity (left) and peak amplitude latency (right) in the auditory cortex of adult rats after SSD were shown. diagnosis of tinnitus through technical collaboration with a medical engineering team at SNU. Recently, we have studied cortical plasticity due to treatment of Hearing loss in mature ears can cause functional reorganization of the auditory auditory-related diseases using electro encephalography(EEG), aiming for more cortex which is speculated to negatively affect the outcome of hearing rehabilitation. * Terms NH: normal hearing; SSD: single-sided deafness; This research investigated the neural plasticity in auditory cortex after SSD in an Contralateral: contralateral side of auditory cortex to the objective diagnoses and reliable clinical treatment. adult rat using multi-unit recording. The contralateral dominance of peak amplitude hearing ear; Ipsilateral: ipsilateral side of auditory cortex to and latency that normally occur in NH were not present in the SSD group, replaced the hearing ear by higher amplitude and faster response in ipsilateral cortex. According to serial recordings at different time points after SSD, different phases in the response of the S e l e c t e d P u b l i c a t i o n s ------auditory cortex were speculated. This study suggests that SSD leads to alteration of contralateral dominance (faster • Test-retest reliability of binaural simultaneous cervical vestibular evoked and larger amplitude of ipsilateral cortex) to acoustic stimulation, likely due to the functional reorganization of the auditory cortex. myogenic potential recording. J Vestib Res. 2015;25(3-4):151-60. • Factors Contributing to Speech Performance in Elderly Cochlear Implanted Patients: An FDG-PET Study: A Preliminary Study. J Int Adv Otol. 2015 Aug;11(2):98-103.

• Difference in Tinnitus Treatment Outcome According to the Pulse Number Hearing Preservation with Drug Delivery : of Repetitive Transcranial Magnetic Stimulation. Otol Neurotol. 2015 Verification of the hearing outcome using dual drug treatment to noise-induced hearing loss animal model. Sep;36(8):1450-6. • Prognostic value of psychological state in cochlear implantation. Acta Saline+D HL control HA+D MP+D Otolaryngol. 2016 Feb;136(2):154-8. • The Relation between Nonverbal IQ and Postoperative CI Outcomes in Cochlear AT Implant Users: Preliminary Result. Biomed Res Int. 2015;2015:313274.

BT Hair cell count The hair cell count number of HL control group was significantly smaller than that of the MP+D group and marginally smaller than the saline+D group and HA+D group. *p value was <0.05 and § p=0.079.

Confocal microscopy image * Terms AT indicates Apical Turn; BT, Basal Turn; D, This study tried to estimate preservation of hearing loss with drug delivery via dexamethasone; HL, Hearing Loss; HA, Hyaluronic Acid; various delivery vehicles. More hair cell loss in the cochlea was identified in the HL MP, methoxy polyethylene glycolepolycaprolactone block Terms D indicates dexamethasone; HL, Hearing Loss; HA, Hyaluronic control group, compared to drug delivered groups. The hair cells in basal turn were copolymer (MPEG-PCL); MT, Middle Turn. Acid; MP, methoxy polyethylene glycolepolycaprolactone block most damaged. White dots indicate the loss of hair cells. copolymer (MPEG-PCL). Vol.2 Vol.2

Excellence Excellence 47 Laboratory of Infection & Immunity Members of Laboratory of Thyroid Research Lab Members of Infection & Immunity Thyroid Research Lab

Our lab has sought to facilitate the Principal Investigator Our lab studies the physiology and diseases of the thyroid gland, one of the Principal Investigator diagnosis, prediction of treatment Myoung-don Oh main endocrine systems in the human body, and the bodily function of the Do Joon Park, Young Joo Park response or prognosis and develo- Professor thyroid hormone. The first aim of our lab is to understand the role of the thyroid Professor Nam Joong Kim, Wan Beom Park, Pyoeng pment of a vaccine for infectious hormone in overall metabolism. We studied the pathophysiologic role of the Sun Wook Cho, Min Joo Kim Gyun Choe diseases by measuring humoral or thyroid hormone in circulation and peripheral tissues, particularly the relationships Researcher Researcher cellular immunity to clinically important between the thyroid receptor and other nuclear receptors(ER, FXR, SHP) and Hyun Jin Sun, Hwan Hee Kim, Gyeong Su Jin Choi viruses and bacteria. For example, we the independent roles of a thyroid stimulating hormone receptor signaling in Seo Jung have investigated cellular immunity extrathyroidal tissues, such as muscle, bone and fat. The second aim is to Graduate student to Mycobacterium tuberculosis to improve the diagnosis of extra-pulmonary understand the pathophysiology of thyroid cancer, the most prevalent cancer Young Shin Song, Sung Hye Kong tuberculosis, or humoral/cellular immunity to vaccinia virus to evaluate the efficacy in Korean women. As our other axis, the lab’s research has focused on the role of a newly developed smallpox vaccine. of genetic alterations in the development of thyroid cancer in Korean patients, In addition, we are interested in research on new emerging viruses. Recently, we searching for the novel driver oncogene or genetic variations related to the poor isolated SFTS (severe fever with thrombocytopenia syndrome) virus for the first time in prognosis of thyroid cancer. One specific subject for the lab is exploring the Korea and reported genetic and immunological characteristics of MERS-CoV (Middle relationship between the clinical characteristics of thyroid cancer, BRAF mutation East respiratory syndrome-corona virus) at the time of the MERS outbreak in Korea. and environmental factors. We also studied the tumor microenvironment of thyroid cancer, focusing on tumor-associated macrophages and tumor angiogenesis. S e l e c t e d P u b l i c a t i o n s ------• Viral Load Kinetics of MERS Coronavirus Infection. N Engl J Med. 2016;375(13):1303-5. • Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, S e l e c t e d P u b l i c a t i o n s ------South Korea. Emerg Infect Dis. 2015;21(12):2186-9. • CXCL16 signaling mediated macrophage effects on tumor invasion of papillary • Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect thyroid carcinoma. Endocr Relat Cancer. 2016 Feb;23(2):113-24. Dis. 2013;19(11):1892-4. • A Possible Association Between Thyroid Cancer and Breast Cancer. Thyroid. 2015 • Diagnostic usefulness of a T-cell based assay for extrapulmonary tuberculosis. Dec;25(12):1330-8. Arch Intern Med. 2007;167(20):2255-9. • Influence of thyroid dysfunction on serum levels of angiopoietin-like protein 6. • Clinical responses to smallpox vaccine in vaccinia-naive and previously Metabolism. 2015 Oct;64(10):1279-83. vaccinated populations: undiluted and diluted Lancy-Vaxina vaccine in a single- • Standard immunohistochemistry efficiently screens for anaplastic lymphoma blind, randomized, prospective trial. J Infect Dis. 2005;192(6):1066-70. kinase rearrangements in differentiated thyroid cancer. Endocr Relat Cancer. 2015 Feb;22(1):55-63. • Therapeutic potential of Dickkopf-1 in wild-type BRAF papillary thyroid cancer via regulation of β-catenin/E-cadherin signaling. J Clin Endocrinol Metab. 2014 Sep;99(9):E1641-9.

Transmission electron microscopy Gene expression analysis on thyroid tumors Ectopic tumor mouse model image of Vero cells infected with MERS-CoV Vol.2 Vol.2

Excellence Excellence 49 Laboratory of Osteoarthritis, Members of Laboratory of Osteoarthritis, Cartilage and Stem Cell Research Cartilage and Stem Cell Research

Our lab focuses on basic and cli- Principal Investigator nical research for joint disease Myung Chul Lee such as osteoarthritis and arti- Professor cular cartilage defect. We have Sahnghoon Lee, Hyuksoo Han been performed studies on the Researcher pathogenesis and genetic factors Hee Jung Park, Sun Young Wang, Haru of osteoarthritis and to develop Yang, Bo Mi Nam, Hyun Cheol Bae stem cell therapeutics and/or eng- ineered biomaterials for the treatment of articular cartilage defect. In addition, we are targeting national healthcare projects such as development of molecular imaging techniques for diagnosis and treatment of articular cartilage diseases and creation of next-generation implants for replacement of bone defects.

S e l e c t e d P u b l i c a t i o n s ------• The effect of platelet-rich plasma on the differentiation of synovium-derived mesenchymal stem cells. J Orthop Res, 32(10):1317-1325, 2014. • Effects of CD14 Macrophages and Proinflammatory Cytokines on Chondrogenesis in Osteoarthritic Synovium-derived Stem Cells. Tissue Eng Part A. 20(19- 20):2680-2691, 2014. • Synovial membrane-derived mesenchymal stem cells supported by platelet- rich plasma can repair osteochondral defects in a rabbit model. Arthroscopy, 29(6):1034-1046, 2013. • Effect of chondroitinase ABC on adhesion and behavior of synovial membrane- derived mesenchymal stem cells in rabbit partial-thickness chondral defects. J Orthop Res, 31(8):1293-1301, 2013. • Chondrogenic potentials of human synovium-derived cells sorted by specific surface markers. Osteoarthritis Cartilage, 21(1):190-199, 2013.

Cartilage regeneration & Chondrocyte differentiation Vol.2 Vol.2

Excellence Excellence 51 Laboratory of Members of Laboratory of Andrology Members of Laboratory of Laboratory of Andrology Innovative Nanobiotechnology Innovative Nanobiotechnology Our lab primarily focuses on investigating the pathophysiology of erectile Principal Investigator Principal Investigator dysfunction(ED) as well as developing preventive and therapeutic strategies for Jae-Seung Paick, Soo Woong Kim As a bio-fusion lab using Seung Hoon Lee the condition. Diabetic ED and ED after radical prostatectomy are difficult to Professor Researcher state-of-the-art technology, treat because Type 5 phosphodiesterase inhibitors(PDE5Is), the first-line therapy Min Chul Cho Chi Kyung Kim, Ye Rim Kim, Han-Gil Jeong, the Laboratory of Nanobio- for ED, are not as effective. Researcher Hang-Rai Kim, Dong-Wan Kang, technology makes a variety For diabetic ED, we established a streptozotocin-induced diabetic model in rats. Ji Sun Chai Do Yeon Kim, Wook Jin Yang, Hyo Shin of nanoparticles and nano- Son, Jung-Min Pyun, Eung Joon Lee, In We investigated change in erectile function and responsiveness to PDE5Is at biomaterials (nano/microgels, Young Choi, Seul Ki Ki, Eun Sun Park, different stages of diabetes, and we demonstrated the important role of corporal nanosponge, microsponge Song I Kim, Ju Hee Han apoptosis as well as up-regulation of RhoA/Rho-kinase(ROCK) pathway in the and hydrogel), and applies the development of diabetic ED. Next, we investigated changes in erectile function techniques and materials to according to the level and start time of glycemic control. medical biology. To overcome human disease, we shun conventional methods and Furthermore, we demonstrated the restoration of erectile function with develop cutting-edge techniques. Our spirit involves a convergence of chemical, agents such as PDE5Is, statin and fasudil(ROCK inhibitor). For post-radical biological and engineering techniques, and we have studies of high value in prostatectomy ED, we set up a cavernous nerve injury(CNI) model in rats, published in prestigious medical journals. We will lead the world in the cure for then studied the molecular mechanisms involved in corporal fibrosis after CNI. human diseases. Sphingosine-1-phosphate(S1P) and RhoA/ROCK1 signaling was involved in corporal fibrosis after CNI. We then demonstrated that early inhibition of ROCK S e l e c t e d P u b l i c a t i o n s ------after CNI could prevent corporal apoptosis and fibrosis by suppressing the • Ceria nanoparticles that can protect against ischemic stroke. Angew Chem Int Akt/Bad/Bax/caspase-3 and LIMK2/cofilin pathways. We hope our work will Ed Engl. 2012;51:11039-43. contribute to a better understanding of the pathogenesis oforganic ED and • Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal development of new therapeutic strategies. pathway. J Cereb Blood Flow Metab. 2013;33:944-53. • Secondary prevention by stroke subtype: a nationwide follow-up study in S e l e c t e d P u b l i c a t i o n s ------46,108 patients after acute ischaemic stroke. Eur Heart J. 2013;34:2760-7. • Involvement of Sphingosine-1-Phosphate/RhoA/Rho-Kinase Signaling Pathway • Obesity-stroke paradox and initial neurological severity. J Neurol Neurosurg in Corporal Fibrosis Following Cavernous Nerve Injury in Male Rats. J Sex Med. Psychiatry. 2015;86:743-7. 2011;8:712–721. • High serum alkaline phosphatase is related to cerebral small vessel disease. • Restoration of Erectile Function by Suppression of Corporal Apoptosis, Fibrosis Atherosclerosis. 2014;232:313-8. and Corporal Veno-Occlusive Dysfunction with Rho-Kinase Inhibitors in a Rat Model of Cavernous Nerve Injury. J Urol. 2015 May;193(5):1716-23. • Involvement of Rho-Kinase/LIM Kinase/Cofilin Signaling Pathway in Corporal Fibrosis after Cavernous Nerve Injury in Male Rats. J Sex Med. 2015 Jul;12(7):1522-32. • EphA2 Is a Potential Player of Malignant Cellular Behavior in Non-Metastatic Renal Cell Carcinoma Cells but Not in Metastatic Renal Cell Carcinoma Cells. PLoS One. 2015 Jul 15;10(7):e0130975. • Investigation of the Effects of the Level of Glycemic Control on Erectile Function and Pathophysiological Mechanisms in Diabetic Rats. J Sex Med. 2012;9:1550–1558. Vol.2 Vol.2

Excellence Excellence 53 Laboratory of Glaucoma: Future Strategies for Management

“Global leader in glaucoma research” Our lab is Asia’s leading glaucoma research center. We are one of the main research labs of the Department of Ophthalmology at Seoul National University Hospital and the coordinating center for large-scaled multicenter clinical trials and epidemiologic studies. Further, we undertake research on vision in collaboration with other eye centers and think tanks throughout the world. The gist of our lab’s mission is investigating the pathogenesis of glaucoma and new strategies for prevention, monitoring and treatment of the disease. These are our main areas of ongoing work:

• Animal models for glaucoma research We are engineering rats to have chronic intraocular pressure(IOP) elevation and using them to study the biology of glaucoma and develop cures. • Intraocular pressure(IOP) sensor research We are developing a miniaturized intraocular pressure(IOP) sensor system for real-time monitoring. • IOP control implant research We are producing an intelligent IOP control implant with an active pressure control valve. • Glaucoma nanomedicine research This study of the glaucoma treatment system uses continuous drug-releasing nanomedicine. • Genetic research This study focuses on the genetic investigation of Korean glaucoma patients.

S e l e c t e d P u b l i c a t i o n s ------• Mucoadhesive microparticles with a nanostructured surface for enhanced bioavailability of glaucoma drug. J Control Release. 2015. • Neuroprotective Effects of Human Serum Albumin Nanoparticles Loaded With Brimonidine on Retinal Ganglion Cells in Optic Nerve Crush Model. Invest Ophthalmol Vis Sci. 2015. • Preliminary study on implantable inductive-type sensor for continuous monitoring of intraocular pressure. Clin Experiment Ophthalmol. 2015. • Nanostructured mucoadhesive microparticles for enhanced preocular retention. Acta Biomater. 2014. • Mitochondrial DNA variant discovery in normal-tension glaucoma patients by next-generation sequencing. Invest Ophthalmol Vis Sci. 2014. Vol.2 Vol.2

Excellence Excellence 55 Laboratory of Glioma Research Members of Laboratory of Glioma Research

Our laboratory is intensively focussing on Principal Investigator glioma research, the most devastating Chul-Kee Park Professor primary tumor in the brain that remains to Jin Wook Kim be cured. A major scope of our laboratory Researcher lies within translational research which Young-Bem Se, Yun-Sik Dho, So Jin Kim, result can be easily applied to clinical harmful influence on the outcome after a stroke. We explore the mechanism in Anna Choi, Tamrin Chowdhury, field. Min Jung Park which inflammation affects brain damage after a stroke, and thereby translate Insights from molecular signatures in tumor tissue are the major interest for the experimental product into clinical research in the prevention and treatment the studies on glioma characterization, treatment resistance, and biomarker of stroke. Additionally, we have studied stem cell therapy for stroke treatment. discovery. We have used diverse kind of methodologies as occasion demands We have tried to confirm whether stem cell transplantation could improve the so far. Currently, we are doing genomics, metabolomics, and cancer immunology outcome after a stroke by neuroprotective mechanisms. In addition, we have tried based research projects on giomas in collaboration with other domestic and to maximize the effectiveness of stem cell therapy by targeting stem cells therapy international research groups. after stroke.

S e l e c t e d P u b l i c a t i o n s ------Selected Publications ------• Dynamic regulation of RNA editing in human brain development and disease. • Effects of Hsp70.1 Gene Knockout on the Mitochondrial Apoptotic Pathway Nat Neurosci. 2016 Aug;19(8):1093-9. After Focal Cerebral Ischemia. Stroke. 2004;35:2195-9. • Therapeutic administration of IL-15 superagonist complex ALT-803 leads • Effects of human neural stem cell transplantation in canine spinal cord to long-term survival and durable antitumor immune response in a murine hemisection. Neurol Res. 2009;31:996-1002. glioblastoma model. Int J Cancer. 2016 Jan 1;138(1):187-94. • Using a Neodymium Magnet to Target Delivery of Ferumoxide-Labeled Human • Genomic dynamics associated with malignant transformation in IDH1 mutated Neural Stem Cells in a Rat Model of Focal Cerebral Ischemia. Hum Gene Ther. gliomas. Oncotarget. 2015 Dec 22;6(41):43653-66. 2010;21:603-10. • Spatiotemporal Evolution of the Primary Glioblastoma Genome. Cancer Cell. • Long-term effects of magnetically targeted ferumoxide-labeled human neural 2015 Sep 14;28(3):318-28. stem cells in focal cerebral ischemia. Cell Transplant. 2015;24(2):183-90. • Mechanism for enhanced 5-aminolevulinic acid fluorescence in isocitrate • Anti-inflammatory effects of fimasartan via Akt, ERK, and NFκB pathways on dehydrogenase 1 mutant malignant gliomas. Oncotarget. 2015 Aug 21;6(24):20266- astrocytes stimulated by hemolysate. Inflamm Res. 2016 Feb;65(2):115-2. 20277.

Neurosurgical Research Laboratory of Members of Laboratory of Stroke Transitional Research Members of Neurosurgical Research Laboratory of Stroke Brain Tumor and Neuronal Stem Cell Laboratory of Brain Tumor and Transitional Research Neuronal Stem Cell Stroke is a major cause of death and

disability. The aim of our lab is transitional Principal Investigator My major fields of clinical interest are Principal Investigator research on stroke. We have sought Byung-Woo Yoon stereotactic functional neuro surgery Sun Ha Paek to develop treatment for stroke, and Professor including deep brain stimulation, neuro- Researcher improve outcomes after a stroke by Sang-Bae Ko ncology, and Gamma knife radiosurgery. Hyo Eun Moon, Hey Min Hwang, Yona applying experimental works related to Fellow The major interest of our lab is the Kim, Jooyoung Lee, Yousik Choi basic mechanisms, deterioration and Tae Jung Kim, Sang Joon An study of tumor development, malignant functional recovery of stroke. A major Resident transformation of brain tumors and Heejung Mo, Kiwoong Nam interest of our lab is the modulation of inflammation related to atherosclerosis, the development of new anticancer regimens as well as the study of cellular biology of Researcher leading cause of stroke, and neural cell death after a stroke. The influence of chronic neuronal stem cells and development of their therapeutic potential in the treatment Young-Ju Kim, Xiu-Li Yang, Sun Jing, La inflammation on atherosclerosis is well known. In addition, indirect neuronal cell damage of neuronal diseases. Many of our studies harvest and bank thousands of brain Vol.2 Vol.2 Mi Kang, Min Kyoung Kang, Eun Sun Jung from the inflammatory response following direct neuronal damage also has a tumors from the operation theater of the study to find early detection markers of 56

Excellence Excellence 57 tumor development and progression in a correlative study of the clinical information Type 2 diabetes mellitus is the of brain tumor patients. We are also doing primary cultures of brain tumors for most common form of diabetes. DMC inhibits adipogenesis via AMPK activation. the study of the genomics of brain tumors by using cDNA microarray and Next Both genetic and environmental Generation Sequencing. With the primary culture of brain tumors, our study factors affect insulin resistance and investigates the underlying mechanism in the development of a brain tumor as well beta cell dysfunction, which are as find early detection and progression markers of brain tumors. the two major pathophysiologic For the study of neuronal stem cells, we are doing primary cultures of a variety abnormalities of type 2 diabetes. of human stem cells such as fat or cord blood-derived mesenchymal stromal We recently studied the 10-year (A) DMC was added to 3T3-L1 preadipocytes at the indicated concentrations simultaneously with cells, and cord blood-derived endothelial progenitor cells from human resources trajectory of insulin secretion and the induction of adipocyte differentiation (DMI treatment) and continuously thereafter. Nine days harvested from the operation theater or delivery room with the permission of resistance in the development of after adipogenesis induction, cells were stained with Oil red O. IRB. We are studying the cellular and molecular biology of neuronal stem cells type 2 diabetes in Korean patients for the development of their therapeutic potential for treatment of brain tumors and found that Koreans are more as well as neuronal diseases of ischemic brain disease and neurodegenerative likely to have impairment in insulin diseases such Parkinson’s disease. secretion compared to westerners. We are investigating the mechanisms Selected Publications ------and therapeutic targets of insulin • Novel morphological and genetic analysis of cancer cells in a 3D microenvironment resistance with special interest in identifies STAT3 as a regulator of tumor permeability barrier function. Cancer Res. PPAR-ν, which is known as the 2015 Dec 16. (B) 3T3-L1 preadipocytes were transfected with master switch of adipogenesis and in SENP2, which apparently plays a critical role siNS or siAMPK (siRNAs of AMPK α1 and α2, 50 nM each) the day before the differentiation • Genomic Characterization of Brain Metastases Reveals Branched Evolution and in metabolic regulation by de-SUMOylation of key metabolic transcription factors. induction. Cells were stained with Oil red O on Potential Therapeutic Targets. Cancer Discov. 2015 Nov;5(11):1164-77. On beta cell dysfunction, we are trying to clarify its mechanisms, by exploring day 9 of adipogenesis. • Fully Implantable Deep Brain Stimulation System with Wireless Power autophagy, endoplasmic reticulum stress and cytosolic calcium homeostasis. Islet Transmission for Long-term Use in Rodent Models of Parkinson's Disease. J transplantation and stem cell differentiation to insulin-producing cells are studied as Korean Neurosurg Soc. 2015 Mar;57(3):152-8. a novel therapy to overcome beta cell dysfunction. A recent study showed that the • An 8-Year Follow-up on the Effect of Subthalamic Nucleus Deep Brain Stimulation gastrointestinal endocrine system plays an important role in maintaining glucose on Pain in Parkinson Disease. JAMA Neurol. 2015 May;72(5):504-10. homeostasis. We are interested in incretin physiology and trying to discover new gut • COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing hormones regulating glucose homeostasis, and also searching for genetic factors Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular of type 2 diabetes and its related complications using a genome-wide approach Migration Through Activating Tie2-FAK Pathway. Exp Neurobiol. 2015 Mar;24(1):55-70. including whole exome sequencing. Through these efforts, we believe we can change the therapeutic paradigm of diabetes in the near future.

Selected Publications ------• 10-year trajectory of β-cell function and insulin sensitivity in the development of Laboratory of Diabetes and Metabolic Members of type 2 diabetes: a community-based prospective cohort study. Lancet Diabetes Disease Research Laboratory of Diabetes and Endocrinol. 2016 Jan;4(1). 27-34. Metabolic Disease Research • SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle. Diabetes. 2015 Jul;64(7). 2420-31. Principal Investigator Kyong Soo Park • Correlation of the incretin effect with first- and second-phase insulin secretions Professor in Koreans with various glucose tolerance statuses. Clin Endocrinol (Oxf). 2015 Young Min Cho, Hye Seung Jung, Soo Jul;83(1). 59-66. Heon Kwak, Sung Soo Chung, Hak Mo Lee • Improved insulin secretion by autologous islet transplantation, compared to oral anti- Researcher diabetic agents, after distal pancreatectomy. Cell Transplant. 2015;24(8). 1615-26. Young Do Koo, Jin Woo Choi, Eun Hye • A genome-wide association study of gestational diabetes mellitus in Korean Choi, Hai Ying Shen, Yu Mi Kang, Mi Na women. Diabetes. 2012 Feb;61(2). 531-41. Kim, Ji Hye Lim, Chang Ho Ahn Graduate student Ji Seon Lee, Jinyan Nan, Mi Gyeong Jang Vol.2 Vol.2

Excellence Excellence 59

Clinical and Research Laboratory for Members of The effect of hASC extract treatment to ALS-Transgenic(SOD1 G93A) mouse model Clinical and Research a 300 b c d Amyotrophic Lateral Sclerosis/Motor 26 20 Laboratory for Amyotrophic 250 24 Neuron Disease and Cell Therapy Lateral Sclerosis/Motor 200 15 22 150 Neuron Disease and Cell 10 20 100 TG-control Therapy 5 Time of fall(sec) 50 TG-hASC-ex Body Weight(g) 18 This lab specializes in the clinical study 0 16 0 Principal Investigator neurons ChAT+motor of Number TG-control TG-hASC-ex and basic research for patho mechanism 60 66 72 78 84 90 96 102 108 114 120 126 132 138 144 150 156 TG-control TG-hASC-ex Jung Joon Sung Age(days) investigation and development of new Professor ==> An improvement of motor function(by rotarod test) and sustained body weight was observed in the hASC extract treatment group(a & b). In cresyl-violet staining and therapeutics (including cell therapy) in immunohistochemistry with anti-choline acetyltransferase(ChAT) in the ventral horn of the lumbar spinal cord at day 110, hASC extract treatment group showed higher number of Yoon Ho Hong, Sung Min Kim, Je Young motor neurons than control group with statistical significance(c & d). ALS (amyotrophic lateral sclerosis or Shin, Hee Woo Lee, Gye Sun Jeon, Ki Lou Gehrig’s disease) and MND(motor Yoon Kim neuron disease), a representative of Researcher rare neurodegenerative diseases. In the clinical field, we first focused on the Jun Soon Kim, Seol Hee Baek, Kyo Min • A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and development of new diagnostic/prognostic biomarkers based on a large-size Choi, So Hyun Ahn, Seok Jin Choi, Sung cytotoxicity in Neuro 2A cells. Biochem Biophys Res Commun(2015);464(1):236-43. patient registry continuously updated by clinicians. Recently, we published articles Woong Lee, Yoo Li Kim, Yu Mi Shim, Bo • Neuroprotective Effect of Human Adipose Stem Cell-Derived Extract in about differential diagnostic markers using electrophysiological(like MUNIX) and Jung Kim Amyotrophic Lateral Sclerosis. Neurochemical Research(2015);DOI 10.1007. respiratory function tests. In addition, we established organized ”biorepository s11064-015-1774-z. systems“ that leads to the storage of biofluids(cerebrospinal fluid and serum) for a long period, and those materials can prove useful in future research. Also, our clinical research on neuromuscular diseases are underway, including that on neuroinflammatory disease like multiple sclerosis/neuromyelitis optica and myopathies. Second, our basic research members have experimented on Laboratory of Rheumatic Disease Members of the cellular/molecular pathomechanisms of various disease-specific genes(ex. Laboratory of Rheumatic SOD1, TDP-43, FUS) mainly for ALS. In this regard, we recently determined the Despite great achievements being made in establishing treatment for systemic Disease cytotoxic effects of phosphomimetic TDP-43 through Drosha’s instability, and rheumatic disease over the past decade, the complexity of the pathogenesis also demonstrated the neurotoxicity of aggregated SOD1 in disease-specific of autoimmune diseases has yet to be elucidated. The Research Laboratory Principal Investigator cell/animal(G93A transgenic mouse) models. Based on our previous results, for Rheumatic Diseases at Seoul National University Hospital focuses on the Yeong Wook Song we’re extending our research to explore pathogenic mechanisms of miRNA and genetics of rheumatic disease as well as translational research of chemokines and Professor interactions between TDP-43 and SOD1 in ALS. Another of our main scientific cytokines participating in autoimmunity. Eun Bong Lee, Eun Young Lee, Jin Kyun themes is the development of novel diagnostic assay and(stem) cell therapeutics We and our collaborators recently identified chemokine CXCL10 as a key Park, Hyun Jung Yoo using the cell fusion technique in rare neurodegenerative diseases. contributor in osteoclastogenesis in the synovium. This ground-breaking work led Researcher We try to generate apoptotic cell-targeted fusogenic stem cells and verify their to the development of anti-human CXCL10 antibodies as potential therapeutic Joo Youn Lee, Jeung Yeon Kim, Shin Eui Kang, Ji Yong Choi, Ji Eun Song, therapeutic potential in vivo as well as in vitro using techniques including cell agents for inhibiting joint damage. Further translational research is underway to Se Hui Shon, Ji Soo Park engineering and molecular/genetic works with induced pluripotent stem cells. Our develop a bivalent antibody recognizing CXCL10 and TNF alpha. final goal is to set up stem cell-based therapies for clinical use, and we hope to Our lab also has interest in genetic diversity and susceptibility associated with the use this technique for other incurable neuromuscular diseases. pathogenesis of autoimmune diseases. We have published genetic studies on rheumatic diseases spanning rheumatoid arthritis, systemic lupus erythematosus, Selected Publications ------ankylosing spondylitis, Behcet’s disease and other vasculitides. We plan to • Potential effect of S-Nitrosylated Protein Disulfide Isomerase on Mutant SOD1 expand our research by studying the association between genetics and treatment Aggregation and Neuronal Cell Death in Amyotrophic lateral sclerosis. Molecular response. Neurobiology(2013);49:796-807. We also have set up a database of clinical samples including serum, synovial • Painful tonic spasm in neuromyelitis optica: incidence, diagnostic utility, and fluid, synoviocytes and cartilage tissues from consenting donors, which enables clinical characteristics. Archives of Neurology(2012);69(8):1026-1031. us to undergo valuable translational research. • Pattern difference of dissociated hand muscle atrophy in amyotrophic lateral sclerosis and variants. Muscle Nerve(2015);51(3):333-337. Selected Publications ------• The dynamic evolution of rheumatology in Korea. Nat Rev Rheumatol. Vol.2 Vol.2 2016;12(3):183-9. 60

Excellence Excellence 61 • CXCR3 polymorphism is associated with male gender and pleuritis in patients herbal extract can decrease the CNV’s size. Recently, our new research seeks to with systemic lupus erythematousus. Hum Immunol. 2014;75(5):466-469. develop novel drugs to fight neovascular AMD other than antibodies to vascular • Therapeutic effect of anti-C-X-C motif chemokine 10 (CXCL10) antibody on C endothelial growth factor, which is the mainstay of neovascular AMD treatment. protein-induced myositis mouse.Arthritis Research & Therapy 2014;16(3):R126. • Genome-wide associateion study identifies GIMAP as a novel susceptibility 4. Plasma biomarker and nano-eyedrops locus for Behcet’s disease. Ann Rheum Dis 2013;72(9):1510-6. We identified biomarkers for diabetic retinopathy from vitreous fluid and plasma, • The interaction between CXCL10 and cytokines in chronic inflammatiory and are performing research to verify the safety and effectiveness of nano- arthritis. Autoimmn Rev 2013;12(5):554-7. eyedrops to exert a long-term therapeutic effect on the eyes.

Selected Publications ------• The diagnostic application of targeted re-sequencing in Korean patients with Retinal Degeneration Research Members of retinitis pigmentosa. BMC Genomics. 2015 Jul 9;16:515. Laboratory(RDRL) Retinal Degeneration Research • Melissa officinalis extract inhibits laser-induced choroidal neovascularization in a Laboratory(RDRL) rat model.PLoS One. 2014 Oct 14;9(10). • Generation of retinal pigment epithelial cells from human embryonic stem cell- Principal Investigator derived spherical neural masses.Stem Cell Res. 2012 Sep;9(2):101-9. Hyeong Gon Yu • Copy number variation of age-related macular degeneration relevant genes in Professor the Korean population. PLoS One. 2012;7(2):e31243. Un Chul Park, Joo Young Shin • Profiling of vitreous proteomes from proliferative diabetic retinopathy and Researcher nondiabetic patients. Proteomics. 2007 Nov;7(22):4203-15. In Hwan Cho, Dae Joong Ma, Woon Hyung Ghim, Jung Bum Park, Young Joo Kim

Our lab is conducting research on retinal degenerative diseases such as diabetic retinopathy, macular degeneration and hereditary retinal diseases that can result Fight against Angiogenesis-Related Members of in vision loss. We aim to elucidate the disease mechanism and develop feasible Blindness(FARB) Laboratory Fight against Angiogenesis- treatment modalities for various retinal degenerative diseases. Related Blindness(FARB) Laboratory 1. Molecular diagnostic research Our lab is doing genetic research on patients with diabetic retinopathy, macular Principal Investigator degeneration and hereditary retinal disease. We established a genetic profile Jeong Hun Kim of Korean patients and discovered new causative genes responsible for retinal Researcher degenerative diseases. Recently, we enhanced the yield of genetic analysis in Jin Hyoung Kim, Hyoung Oh Jun, Dong retinitis pigmentosa patients with the application of next-generation sequencing Hyun Jo, Sung Wook Park, Hyun Bum technology. We anticipate these results could serve as a foothold for the use of Song, Chang Sik Cho, Byung Joo gene therapy in treatment for retinal degenerative disease. - Retinal vascular diseases following the blood-retinal barrier breakdown: Retinopathy of prematurity, diabetic retinopathy and age-related macular 2. Stem cell research degeneration. We developed a new technique to differentiate retinal pigment epithelial cells and - Blood-retinal barrier: Regulatory mechanisms to form and maintain the blood- photoreceptor precursor cells from human embryonic stem cells. We confirmed retinal barrier at the interface of neurogenesis, gliogenesis and angiogenesis. their survival in the eyeball and improvement of visual function after stem cell - T umor angiogenesis in retinoblastoma. transplantation in animal models of retinal degeneration. We are planning to soon - Normal eye development. conduct clinical trials on these stem cells in patients with retinal degenerative diseases. Selected Publications ------• Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic 3. Development of new drug retinopathy. Diabetes. 2014/63(9)/3057-3068. We developed the choroidal neovascularization(CNV) animal model that • VEGF-binding aptides and the inhibition of choroidal and retinal Vol.2 Vol.2 corresponds to age-related macular degeneration(AMD) and confirmed that an oral neovascularization. Biomaterials. 2014/35(9)/3052-3059. 62

Excellence Excellence 63 2. Find novel epigenetic regulators, particularly histone modification enzymes, involved in cancer initiation, progression and metastasis and elucidate relevant molecular mechanisms. 3. Discover and validate novel biomarkers of disease prognosis and responses to treatments in urological cancers. Our efforts are anticipated to assist in providing more effective diagnostic and therapeutic strategies for urological cancers by targeting specific genetic and • Human apolipoprotein(a) kringle V inhibits ischemia-induced retinal epigenetic markers. neovascularization via suppression of fibronectin-mediated angiogenesis. Diabetes. 2012/61(6)/1599-1608. To accomplish these goals, we established specific disease modeling in vitro, • The inhibition of retinal neovascularization by gold nanoparticles via suppression such as enzalutamide-resistant prostate cancer cell lines, as well as in vivo, of VEGFR-2 activation. Biomaterials. 2011/32(7)/1865-1871. including orthotopic and the mestastatic kidney cancer mouse model by using • Autophagy-induced regression of hyaloid vessels in early ocular development. an immune compromised mouse and knock-out mouse system. Molecular Autophagy. 2010/6(7)/922-928. techniques are used to prove our hypotheses, including real time-RT PCR, western blotting, chromatin-immunoprecipitation, immufluorescence using confocal microscopy, gene silencing and overexpression with specific gene cloning and various in vitro phenotypic and functional assay.

Laboratory of Urological Oncology Members of S e l e c t e d P u b l i c a t i o n s ------Laboratory of Urological • PDLIM2 suppression efficiently reduces tumor growth and invasiveness of human Oncology castration-resistant prostate cancer-like cells. Prostate. 2016;76(3):273-85. • Pathological T0 Following Cisplatin-Based Neoadjuvant Chemotherapy for Principal Investigator Muscle-Invasive Bladder Cancer: A Network Meta-analysis. Clin Cancer Res. Hyeon Hoe Kim, Cheol Kwak, Ja Hyeon Ku Professor 2015. [Epub ahead of print] Chang Wook Jeong, Kyoung Hwa Lee • PHF2 histone demethylase acts as a tumor suppressor in association with p53 Researcher in cancer. Oncogene. 2015 May 28;34(22):2897-909. Minyong Kang, Hye Sun Lee, Yongjun Quan • Inhibition of autophagy potentiates atorvastatin-induced apoptotic cell death in human bladder cancer cells in vitro. Int J Mol Sci. 2014;15(5):8106-21. • Simvastatin induces apoptosis in castrate resistant prostate cancer cells by deregulating nuclear factor-κB pathway. J Urol. 2013;189(4):1547-52.

Establishment of orthotopic RCC model

Our laboratory is committed to building on research findings to develop novel Injection Day 3 Day 10 Day 25 methods for the prevention, diagnosis, and treatment of urological malignancies, particularly cancers of the prostate, kidney and bladder.

The specific aims of our laboratory are : Balb/c mouse * Peritoneal injection with D-luciferin (150 ug/kg) 1. Discover novel target genes involved in cancer initiation, progression and (wild type; male, 6 week) Vol.2 Vol.2 metastasis and explore relevant molecular mechanisms. 64

Excellence Excellence 65 Laboratory of Reproductive Bioengineering Members of Laboratory of Reproductive Bioengineering

Principal Investigator Seung-Yup Ku Professor Yoon Young Kim Researcher Kyung Mee Cho, Hae Jun Min, Chung Hwan Kim, Mi Ae Lee

Analyses of the developmental process in female reproductive organs using rodent and nonhuman primate model and translational researches through approaching with bioengineering.

Selected Publications ------• MicroRNAs transfected into granulosa cells may regulate oocyte meiotic competence during in vitro maturation of mouse follicles / Human Reproduction / 28(11) / 3050-61. • Effects of urinary and recombinant gonadotropins on in vitro maturation outcomes of mouse preantral follicles / Reproductive Sciences / 20(8) / 909-16. • The effect of estrogen compounds on human embryoid bodies / Reproductive Sciences / 20(6) / 661-9. • Anti-aging effects of vitamin C on human pluripotent stem cell-derived cardiomyocytes / Age (Dordr)/ 35(5) / 1545-57. • Gonadotropin ratio affects the in vitro growth of rhesus ovarian preantral follicles / Journal of Investigative Medicine / 64(4) / 888-93. • Induction of multiple ovulation via modulation of angiotensin II receptors in in vitro ovarian follicle culture models / Journal of Tissue Engineering and Regenerative Medicine / 2016;doi: 10.1002.

Establishment of in vitro follicular growth model

Mouse in vitro cultured ovarian multi-follicles Uterus of non-human primate H&E staining of non-human primate Immunocytochemistry of proliferating

Vol.2 Vol.2 ovarian follicle (containing oocyte) cells in the mouse ovary

Excellence Excellence 67 coating on scaffolds, we try to enhance the adherence and proliferation of various Laboratory of Reproductive Genetics Members of stem cells (iPS, MSC) and improve the regeneration of mucous membrane within the trachea. Demand for treatment of voice disorders is increasing due to aging Laboratory of Reproductive or vocal fold paralysis. Our lab is developing a number of advanced materials for Genetics Our laboratory seeks to understand the genetic injection laryngoplasty for vocal fold augmentation to treat glottic gap. Our goal is

basis of female reproductive disorders causing Principal Investigator to reduce the migration of the material by mussel-inspired adhesion peptide and infertility such as endometriosis, polycystic ovary Young Min Choi enhance vocal fold regeneration by incorporating slow-release growth factors and syndrome and premature ovarian failure. Professor pDNA. We are expanding our research to develop an artificial vocal fold that mimics A major task is to identify DNA polymorphisms Jin Joo Kim, Kyu Ri Hwang the vibration of the normal vocal fold by using super-hydrogel. which are associated with the development of Researcher Our lab’s focus is also treatment of intractable oral ulcers through preconditioned common female reproductive disorders. Min A Hong, Jong Mi Kim stem cells that secrete factors (such as VEGF, SOD and IL-10) favorable for ulcer We also investigate the pharmacogenetic aspect regeneration. We are developing an advanced form of sheet comprised of these of controlled ovarian hyperstimulation for in vitro preconditioned cells. This cell sheet is applicable to ulcers of various sizes for more fertilization and embryo transfer. effective treatment than via injection of stem cells, because a vast number of cells can directly come in contact with the region of lesion. Selected Publications ------To treat xerostomia that occurs due to aging, menopause and radiation exposure of • Association of CDKN2B-AS and WNT4 genetic polymorphisms in Korean the head and neck region, our lab is aiming to improve the functions of the salivary patients with endometriosis. Fertil Steril 2014;102(5):1393-7. gland through an anti-inflammatory, bio-inspired hydrogel infused with stem cells, • Complete phenotypic and metabolic profiles of a large consecutive cohort Finally, we are developing an artificial esophagus to reduce complications related to of untreated Korean women with polycystic ovary syndrome. Fertil Steril. conventional surgery of the esophagus. Using 3-D printing, bioreactor and proper 2014;101(5):1424-3. combination of stem cells, we are striving to reproduce a functional esophagus. • Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes. Clin Endocrinol Selected Publications ------(Oxf). 2012;77(3):439-45. • Hydrogel-laden paper scaffold system for origami-based tissue engineering. • Association study of anti-Mullerian hormone and anti-Mullerian hormone type Proc Natl Acad Sci. 2015, 112(5). 15426-31. II receptor polymorphisms with idiopathic primary ovarian insufficiency. Hum • Synergistic effect of laminin and mesenchymal stem cells on tracheal mucosal Reprod. 2013;28(12):3301-5. regeneration / Biomaterials. 2015, 44. 134-42. • The PAI-1 4G/5G and ACE I/D polymorphisms and risk of recurrent pregnancy • microspheres/pluronic F127 hydrogel: long-term in vivo study for the treatment loss: a case-control study. Am J Reprod Immunol, 2014;72(6):571-6. of glottal insufficiency. PLoS One. 2014, 9(1). e85512. • Tracheal reconstruction with asymmetrically porous polycaprolactone. pluronic F127 membranes. Head Neck. 2014;36(5):643-51. • Polycaprolactone spheres and theromosensitive Pluronic F127 hydrogel for vocal fold augmentation: in vivo animal study for the treatment of unilateral vocal BiRO(Laboratory of Bioinspired Members of BiRO fold palsy. Laryngoscope. 2013;123(7):1694-703.

Regenerative Medicine for Principal Investigator Seong Keun Kwon Otorhinolaryngologic field) Professor Eun Jae Chung Researcher Otolaryngological diseases that occur in the larynx, oral cavity, pharynx, salivary In Gul Kim, Hee Jin Ahn, Mi Jung Han, Ha gland, trachea and esophagus have detrimental effects on the fundamental Na Cho, Sang Jee Lee, Soo Yeon Kim activities necessary for human survival: phonation, communication, swallowing, digestion and breathing. Even after recovery, functional impairments can continue to influence the daily lives of patients. The ultimate goal of\ our lab is to restore the functional aspect of impaired areas through research using stem cells, constitutive growth factors, biocompatible and biomimetic scaffolds, and bioreactors. To cure tracheal stenosis that occurs for various reasons, our lab is developing patient-specific and custom- Vol.2 Vol.2 made scaffolds built through 3-D printing. By applying bioreactors and ECM 68

Excellence Excellence 69 Biomaterials Processing & Application Lab Members of Plastic Surgery Laboratory for Tissue Members of Biomaterials Processing & Plastic Surgery Laboratory for Application Lab Engineering & Medical Devices Tissue Engineering & Medical The Biomaterials Processing & Devices Application Lab(BPAL) focuses Principal Investigator on developing biomaterial-based Young Bin Choy Principal Investigator Researcher devices for applications in medicine, Tae Hyun Choi Seung Ho Lee, Myung Hun Kim, Byung Researcher such as micro- and nano-particles Hwi Kim, Beom Kang Huh, Se Na Kim, Woojune Hur, Wufue Maierdanjiang, and implantable devices for drug Yong Chan Cho, Jae Yeon Lee, Song Ah Yinglan Piao, Cheolmin Ha, Byoungjun delivery and medical device Ko, Byung Ho Shin, Dong Yeon Nam, Han Jeon, Geeho Park, Young Min Kim, combination products. Bi Ji, Ji Min Kwak, Beom Su Jeon, Eunjung Choi, Jungah Kim, Huang Yan At this lab, biocompatible or biodegradable polymers are processed through Jungah Kim, Huang Yan novel methods to form nanoparticles and microparticles. These particles are loaded with various types of drugs depending on their specific purposes in clinical practice. The lab is especially interested in custom-shaped implantable devices for drug delivery(i.e., devices structured with precise dimensions, geometry or internal porosity) to achieve highly accurate, directional and targeted delivery of therapeutic agents, meaning further improvement in therapy. Our areas of research interest also include development of medical device The Plastic Surgery Laboratory for Tissue Engineering and Medical Devices combination products,(e.g., drug-eluting surgical suture or breast implant) to is researching the drug delivery system, genetic causes of rare diseases, side domestically reduce side effects following implantation of the devices. effects of plastic surgery implants, 3-D printing, physical properties of skin cancer (melanoma), tissue expanders, facial recognition systems, anti-obesity Selected Publications ------drugs, skin regeneration, wound healing, hemagioma and skin on a chip. • Mucoadhesive Microparticles with a Nanostructured Surface for Enhanced Bioavailability of Glaucoma Drug, Journal of Controlled Release, 220, 180-188. Selected Publications ------• Acute Suppression of TGF-ß with Local, Sustained Release of Tranilast against • MRI molecular imaging using GLUT1 antibody-Fe3O4 nanoparticles in the the Formation of Fibrous Capsules around Silicone Implants, Journal of hemangioma animal model for differentiating infantile hemangioma from Controlled Release, 200, 125-137. vascular malformation. Nanomedicine. 2015:11(1). 127-135. • Implantable Micro-chip for Controlled Delivery of Diclofenac Sodium, Journal of • Self-assembling peptide nanofibers coupled with neuropeptide substance P for Controlled Release, 196, 52-59. bone tissue engineering. Tissue Engineering Part A. 2015:101(2). 320-329. • Nanostructured mucoadhesive microparticles for enhanced preocular • Bioabsorbable bone plates enabled with local, sustained delivery of alendronate rentention, Acta Biomaterialia, 10 (1), 77-86. for bone regeneration. Journal of Conrolled Release. 2016:222. 97-106. • Surgical suture assembled with polymeric drug-delivery sheet for sustained, • Alleviation of capsular formations on silicone implants in rats using local pain-relief, Acta Biomaterialia, 9(9), 8318-8327. biomembrane-mimicking coatings. Acta Biomaterialia. 2014:10(10). 4217-4225. • Regeneration of peripheral nerves by transplanted sphere of human mesenchymal stem cells derived from embryonic stem cells. Biomaterials. 2012:22(29). 7039-7046. IOP decrease(%) Tissue reation Thickness(㎛) 120 original suture PLGA_S_suture PLGA_IB_suture M_PLGA_IB_S_suture 30 100

80 20 60

40 10

0 0 0 2 4 6 8 10 12 14 1 3 5 6 7 9 Time(h) Time(Day)

Mucoadhesive Microparticles with a Nanostructured Surface for Enhanced Surgical suture assembled with polymeric drug-delivery sheet for sustained, local pain relief. Bioavailability of Glaucoma Drug. Vol.2 Vol.2

Excellence Excellence 71 Research Institute of Plastic and Members of RIPRS

Reconstructive Surgery(RIPRS) Principal Investigator Sung Tack Kwon Professor Kyung Won Minn, Hak Chang, Ung Sik Jin, Sang Wha Kim Researcher Byung Jun Kim, Ki Yong Hong, Ryun Suk Lee, Hyun Jung Kim

The Research Institute of Plastic and Reconstructive Surgery(RIPRS) was established in May 2005 for the purpose of expanding and stimulating basic research on plastic and reconstructive surgery in Korea. The subjects of our research can be subdivided. The first is to obtain the technique for producing tissue for reconstruction with stem cell and tissue engineering. A sufficient amount of adipose-derived stem cells(ADSC) can be easily acquired. And because ADSC can induce angiogenesis, a positive effect on degenerative disease can also be expected. The second project is to develop new drugs or therapy for healing wounds with less scarring. Recently our institution has started clinical trials of therapy with stem cells on chronic wounds such as DM foot lesion. Third is educating residents or students about the procedure of microsurgery, such as microanastomosis. RIPRS will contribute to advance mediating or regenerative medicine through research on stem cell and tissue engineering.

Selected Publications ------• Regulation of Transforming Growth Factor β1, Platelet-Derived Growth Factor, and Basic Fibroblast Growth Factor by Silicone Gel Sheeting in Early-Stage Scarring. Arch Plast Surg. 42(1). 20-27. • The superficial inferior epigastric artery flap and its relevant vascular anatomy in korean women. Archives of Plastic Surgery. 41(6). 702-708. • Comparative analysis of human epidermal and peripheral blood γ δ T cell cytokine profiles. Annals of Dermatology. 26(3). 308-313. • Modified seromuscular patch flap for reinforcing an anastomosis site in hypopharyngeal reconstruction using free jejunal transfer: an anatomical and clinical study. Annals of Plastic surgery. 72(4). 435-438. • Effectiveness of autologous serum as an alternative to fetal bovine serum in adipose-derived stem cell engineering. Cell Tissue Bank. 14(3). 413-422. Vol.2 Vol.2

Excellence Excellence 73 Laboratory of Pediatric Neurology Members of Pediatric Neurosurgery Members of Laboratory of Pediatric Pediatric Neurosurgery Neurology The Division of Pediatric Neurology The objective is the development of Principal Investigator Principal Investigator Seung-Ki Kim undertakes the diagnosis and new therapies and studies on the Ki Joong Kim, Jong-Hee Chae, Byung Professor treatment of pediatric patients with basic causes of pediatric brain tumors, Chan Lim Kyu-Chang Wang, Ji Hoon Phi, Seung Ah various neurological disorders in Moyamoya disease, epilepsy and Professor Choi, the central and peripheral nervous nervous system diseaseResearch on Jin sook Lee, Anna Cho Researcher system such as congenital anomalies, Researcher the congenital developmental anomaly Myeong Suk Lee, Youn Joo Moon, Pil Ae epilepsies(particularly medically Min jeong Kim, Soo jin Park, Bo ram Seo of the neural system led by Pf Wang KC Kwak, Jangra Anshika, Chan Hee Lee, intractable types), vascular disorders, neurometabolic and neurogenetic diseases, has been taken over by the Neural Development and Anomaly Laboratory of the Young Eun Lee CNS infections, and movement, neuromuscular and mitochondrial disorders. Our Department of Anatomy since 2015. vision is to provide patients with effective diagnosis and management using up- to-date and state-of-the-art clinical skills and technologies. S e l e c t e d P u b l i c a t i o n s ------In 2008, we launched the Pediatric Clinical Neuroscience Center(PCNC) at SNU • miR-192 suppresses leptomeningeal dissemination of medulloblastoma by Children’s Hospital, which is specialized in clinical practice as well as translational modulating cell proliferation and anchoring through the regulation of DHFR, research. The PCNC comprises an outpatient clinic, in-patient ward(33 beds), and integrins, and CD47, Oncotarget, 2015 Dec 22;6(41):43712-30. labs for electrophysiology and basic research. A multidisciplinary team with five • Identification of tumour initiating cells using the stem cell marker aldehyde child neurologists, three pediatric neurosurgeons and two rehabilitation doctors dehydrogenase, Eur J Cancer, 2014 Jan;50(1):137-49. work together to provide comprehensive and rapid management in a non-stop • Deregulation of Retinaldehyde Dehydrogenase 2 Leads to Defective Angiogenic process from admission to operation and rehabilitation. Function of Endothelial Colony-Forming Cells in Pediatric Moyamoya Disease, Our lab is constantly evolving to meet new challenges and can provide advanced Arterioscler Thromb Vasc Biol, 2015 Jul 28;35(7):1670-7. genetic diagnosis using next-generation sequencing with collaboration through • Disulfiram modulates stemness and metabolism of brain tumor initiating cells in bioinformatics and functional biology core laboratory at SNU’s College of atypical teratoid/rhabdoid tumors, Neuro-Oncology, 2015 Jun;17(6):810-21. Medicine and the Biomedical Research Institute of SNUH. • Clinically applicable human adipose tissue-derived mesenchymal stem cells Our lab focuses on myopathy and its patho-genetic mechanism, epilepsy and its delivering therapeutic genes to brainstem gliomas, Cancer Gene Therpy, 2015 genetics, and neurogenetic diseases with its genetic and pathologic mechanisms. 22, 302–311. Annually over 500 undiagnosed pediatric patients with rare diseases visit our center, and we applied the best appropriate diagnostic tools for each individual so that the undiagnosed patients received appropriate treatment based on precision medicine as well as correct diagnosis. We hope to be one of the world’s best teams for clinical pediatric neuroscience.

Selected Publications ------A B D0 D1 D3 D9 D12 D16 300 • Trends in Antiepiliptic Drug Prescriptions for Childhood Epilepsy at a Tertiary PBS 250 NC-miR Children’s hopital in Korea, 2001-2012. Paediatr Drugs. 2015 Dec;17(6):487-96. 200 miR-192 • SATB2-associated syndrome presenting with Rett-like phenotypes. Clin Genet. 150 100

2016 Jun;89(6):728-32. 50 Relative BLI units

0 • Consecutive analysis of mutation spectrum in the dystrophin gene of 507 0 3 9 12 16 Day 12

10 Korean boys with Duchenne/Becker muscular dystrophy in a single center. D3 D9 D12 D16 8 PBS vs. NC-miR P>0.05 P>0.05 P>0.05 P>0.05 6

Muscle Nerve. 2016 Sep 4. 4 PBS vs. miR-192 P>0.05 P>0.05 P>0.05 P>0.001 • Noninvasive prenatal diagnosis of duchenne muscular dystrophy: 2 miR-192 NC-miR PBS NC-miR vs. miR-192 P>0.05 P>0.05 P>0.01 P>0.001 comprehensive genetic diagnosis in carrier, proband, and fetus. Clin Chem. 2015 Jun;61(6):829-37.

• Utility of next generation sequencing in genetic diagnosis of early onset Pediatric neurosurgery lab conducts research focusing on brain tumor, moyamoya disease, epilepsy, and hydocephalus in children.Biological mechanism underlying these diseases are actively neuromuscular disorders. J Med Genet. 2015 Mar;52(3):208-16. being investigated, and aims to develop innovative diagnostic marker and therapies. Vol.2 Vol.2

Excellence Excellence 75 Members of Laboratory of Pediatric Urology C MP GT Laboratory of Pediatric Urology

Principal Investigator Kwan jin Park

Professor (%) 25 Young Jae Im 20 Researcher 15 10 Sun Hee Lee, Hye Jin Park 5 0 C MP G T GT G T

Health System Data Mining Lab Members of Our laboratory is dedicated to basic research on pediatric urological disease. Health System Data Mining Lab The three main areas of our research are 1) developmental contractility changes

of the bladder’s smooth muscle 2) setting up an effective treatment strategy for Principal Investigator micropenis and 3) seeking noninvasive diagnostic methods for vesicoureteral Sang Min Park reflux using metabolomics. Researcher Sugyeong Kim, Donghoon Lee, Go-Un Selected Publications ------Jung, Kyuwoong Kim • Efficacy of salvage interferential electrical stimulation therapy in patients with medication-refractory enuresis: a pilot study. Int Neurourol J. 2013 Sep;17(3):139-44. • An analysis of long-term occurrence of renal complications following pediatric pyeloplasty. J Pediatr Urol. 2014 Dec;10(6):1083-8. • The diagnosis of febrile urinary tract infection in children may be facilitated by The Health System Data Mining Lab of the Center for Medical Innovation at urinary biomarkers. Pediatr Nephrol. 2015 Jan;30(1):123-30. Seoul National University Hospital Biomedical Research Institute focuses on a • Perceived barriers and difficulties of intermittent catheterization: In Korean wide range of research based on public health big data, pharmacoepidemiology patients with spinal dysraphism and their parents. Neurourol Urodyn. 2016 and machine learning to further advance the quality of public health. Through Mar;35(3):395-9. simulation-based cost-effectiveness analysis, we research the economic effects of • Predictive factors of chronic kidney disease in patients with vesicoureteral reflux public health policy. Our previous research projects included a cost-effectiveness who were treated by surgery and followed until post-puberty. J Urol. 2015 Nov. analysis of gastric cancer screening and review of the effects from the change DOI : http://dx.doi.org/10.1016/j.juro.2015.11.004. in cancer inspection rate and medical insurance cost on health insurance public financing. At the moment, we are conducting a cost-effectiveness analysis of the hepatitis B immunization project for postnatal care in Korea. We study big data on public health to find expected and unknown information related to human health and life, and unexpected health effects caused by frequently prescribed drugs. Based on machine learning algorithms, we plan to develop a signal detection system to detect unknown health effects of frequently prescribed drugs. Another project is to apply computer vision and machine learning technology to medical image detection to study the bone morphology of the human skeleton. In the near future, we will develop an automated system of medical image detection based Vol.2 Vol.2 on deep learning to enable more accurate and correct clinical decisions. 76

Excellence Excellence 77 Laboratory for Cerebrovascular Disease Members of Probabilistic 10,000,000,000 Sensitivity Laboratory for 8,000,000,000 Analysis for Cerebrovascular Disease Perinatal Hepatitis 6,000,000,000 B Prevention 4,000,000,000 Principal Investigator Program in the Jeong Eun Kim Republic of Korea 2,000,000,000 Professor 0 Hyun Seung Kang, Won-Sang Cho -2,000,000,000 Researcher -4,000,000,000 Eun Jin Ha

-6,000,000,000 Incremental Cost Incremental

-8,000,000,000 WTP=2.5E7

-10,000,000,000

-12,000,000,000

-14,000,000,000

-16,000,000,000

-18,000,000,000 -600 -300 0 300 600 900 1,200 1,500 1,800 Incremental Effectiveness Natural History of Cerebrovascular Disease To show the natural history of a certain disease, prospective cohort study is essential. Unfortunately, only a limited number of such studies exist in Korean

Prediction Model neurosurgery. So our research team built a multi-center network for prospective for Osteoarthritis clinical studies on cerebrovascular disease, and in 2015, the Paraclinoid or Osteoporosis High entropy difference Based on X-ray KL-grade 0 Aneurysm Prospectively-driven Observational Analysis(PANDORA) study was Images 정상관절 launched. Moreover, our researchers plan to conduct another prospective cohort study about asymptomatic cerebral cavernous malformation.

KL-grade 4 Development of Clinically Relevant Animal Models for Cerebrovascular

High entropy difference Disease Animal models are critical tools for connecting bench work to clinical trials. We are developing an ischemic cerebral occlusion model in mice that will prove more consistent and relevant to the clinical setting of cerebral ischemia. With collaboration from nuclear medicine researchers, we are proceeding with making a subarachnoid hemorrhage model of rabbits and developing drugs for preventing vasospasm. We are also planning a novel animal model for Moyamoya Selected Publications ------disease. • Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systemic review and meta-analysis of randomised controlled trials. Pathogenesis of Adult Intracranial Occlusive Vascular Disease British Medical Journal(2013)/346/1-22. Many intracranial occlusive vascular diseases have similarangiographic features • Use of selective serotonin reuptake inhibitors and risk of fracture: A systematic but with various causes such as atherosclerosis, vasculitis and Moyamoya disease, review and meta-analysis/J Bone Miner Res.(2012)/27/1166-95. especially in adult patients. We seek to elucidate the possible pathogenesis to • Use of acid-suppressive drugs and risk of pneumonia: a systematic review and separate different causes using real samples from patients. meta-analysis. CMAJ(2011)/163(3)/310-9. • Prediagnosis smoking, obesity, insulin resistance, and second primary cancer Pathogenesis of Intracranial Aneurysms risk in male cancer survivors: National Health Insurance Corporation Study. J An intracranial aneurysm is known to be a degenerative lesion. Yet certain Clin Oncol(2007)/25/4835-43. intracranial aneurysms have unique clinical settings such as multiple aneurysms • Impact of prediagnosis smoking, alcohol, obesity, and insulin resistance on in younger patients, aneurysms with other vascular pathologies and genetic survival in male cancer patients: National Health Insurance Corporation Study. J diseases. Our focus is on these intracranial aneurysms in terms of the genetic Vol.2 Vol.2 Clin Oncol(2006)/24/5017-24. pathogenesis of intracranial aneurysms. 78

Excellence Excellence 79 Laboratory of Neurorehabilitation & Members of Laboratory of Regenerative Medicine Neurorehabilitation & Regenerative Medicine

Principal Investigator The Laboratory of Neurorehabilitation Moon Suk Bang, Sun Gun Chung, & Regenerative Medicine(LNRM) Shi-Uk Lee, Byung-Mo Oh, Se Hee Jung, focuses on musculoskeletal, pe- Han Gil Seo ripheral and central neurological Professor disorders. Our goal is to overcome Seung Hak Lee functional impairment caused by Researcher these diseases through development Jin Ju Lee, Jae Won Min, Bo-mi Kwon, of a new diagnostic and therapeutic Eun Young Heo method. Recently, we have applied stem cell therapies and noninvasive brain stimulations(rTMS, tDCS) to a number of animal models.

Selected Publications ------• Concurrent use of granulocyte-colony stimulating factor with repetitive transcranial magnetic stimulation did not enhance recovery of function in the early subacute stroke in rats. Neurological Sciences, 36(5), 771-777. • Feasibility of 18F-FDG PET as a noninvasive diagnostic tool of muscle Development of Cell-based Therapy for Treatment of Ischemic denervation: a preliminary study. Journal of Nuclear Medicine, 55(10), 1737-1740. Cerebrovascular Disease • The molecular evidence of neural plasticity induced by cerebellar repetitive Endothelial progenitor cells(EPCs) and smooth muscle progenitor cells(SPCs) transcranial magnetic stimulation in the rat brain: A preliminary report. play an important role in vasculogenesis and angiogenesis. We are striving to Neuroscience letters, 2014, 575: 47-52. evaluate the biological effect of EPCs and SPCs in the animal models of cerebral • Functional improvement and neuroplastic effects of anodal transcranial direct ischemic disease and apply cell-based therapy using these EPCs in the treatment current stimulation (tDCS) delivered 1day vs. 1week after cerebral ischemia in of ischemic cerebrovascular disease. rats. Brain research, 1452, 61-72. • Early motor balance and coordination training increased synaptophysin in Development of Devices for Aneurysm Clipping subcortical regions of the ischemic rat brain. Journal of Korean medical science, Through cooperation with researchers in material engineering and government 25(11), 1638-1645. think tanks, we are making clips and an endoscope system for aneurysm clipping.

Selected Publications ------• Smooth-muscle progenitor cells isolated from patients with moyamoya disease: novel experimental cell model. J Neurosurg. 2014;120:415-25. • A retrospective analysis on the natural history of incidental small paraclinoid unruptured aneurysm. J Neurol Neurosurg Psychiatry. 2014;85:289-94. • Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data. Lancet neurology. 2016;15:166–173. • Expression of cellular retinoic acid-binding protein-I(CRABP-I) in the cerebrospinal fluid of adult onset moyamoya disease and its association with clinical presentation and postoperative haemodynamic change. J Neurol Neurosurg Psychiatry. 2014 ;85:726-31. • 1H-NMR-based metabolomic analysis of cerebrospinal fluid from adult bilateral moyamoya disease: comparison with unilateral moyamoya disease and Vol.2 Vol.2 atherosclerotic stenosis. Medicine (Baltimore). 2015;94(17):e629. 80

Excellence Excellence 81 Laboratory of Neonatal and Members of Effect of hyperoxia on the lung alveolarization and angiogenesis Laboratory of Neonatal and Developmental Biology Developmental Biology A D control hyper oxia control hyper oxia Principal Investigator Han-Suk Kim Neonatal acute lung injury in preterm Professor infants is common, and its etiology Ee-Kyung Kim, Seung Han Shin appears to be multifactorial. Researcher Various risk factors in either the Kyung Yeop Lee B C P=0.001

antenal or postnatal period can ) P<0.001 ㎛ 60 P=0.03 1000 3

cause an inflammatory response 50 800

40 2 within the premature lung. This 600 30 400 trauma can result in a chronic lung 20 1 200 10 / lung) 0 2 0

disease of prematurity known as bronchopulmonary dysplasia(BPD), which is PECAM_Ⅰ % of distribution 0 mean chor d length( ㎛ control hyper oxia alveolar surface area ( control hyper oxia control hyper oxia recognized as a developmental arrest of the immature lung. The Neonatology Laboratory of Neonatal and Developmental Biology at Seoul National University Hospital conducts human and animal studies on preterm lung oropharyngeal administration of colostrum in extremely premature infants disease to probe the pathogenesis of BPD and subsequent complications such as pulmonary artery hypertension. Other subjects such as diseases from an immature brain and intestines are also conducted at this lab.

Selected Publications ------• Expression of autotaxin and lysophosphatidic acid receptors 1 and 3 in the developing rat lung and in response to hyperoxia. Free Radic Res. 2015;49(11):1362-70. • Oropharyngeal colostrum administration in extremely premature infants: an RCT. Pediatrics. 2015 Feb;135(2):e357-66. • Serial changes of serum endostatin and angiopoietin-1 levels in preterm infants with severe bronchopulmonary dysplasia and subsequent pulmonary artery hypertension. Neonatology. 2014;106(1):55-61. Expression of rat lung autotaxin, • Heat shock pretreatment reduces intestinal injury in a neonatal rat model of LPAR1, and LPAR3 after exposure to hyperoxia or normal air early necrotizing enterocolitis. Neonatology. 2013;103(1):1-6.

• Correlation of urinary inflammatory and oxidative stress markers in very low birth Double-fluorescence immunohistochemical staining. Normal rat lung was double stained for endoglin, weight infants with subsequent development of bronchopulmonary dysplasia. ALK1, ALK5 (A, B, C; green) and PECAM-I (D, E, F; red) and then counter-stained for DAPI (G, H, I; blue) Free Radic Res. 2011 Sep;45(9):1024-32. normal air Vol.2 Vol.2

Excellence Excellence 83 Selected Publications ------• A Randomized, Controlled Trial of Oral Intestinal Sorbent AST-120 on Renal Laboratory of Transplantation and Members of Function Deterioration in Patients with Advanced Renal Dysfunction. Clin J Am Laboratory of Transplantation Kidney Disease and Kidney Disease Soc Nephrol 2016;11: ePress. • Sex, Age, and the Association of Serum Phosphorus With All-Cause Mortality in End-stage renal disease requiring renal transplantation or dialysis is a major health Principal Investigator Adults With Normal Kidney Function. Am J Kidney Dis 2016 67(1):79-88. problem. Only a few therapeutic options are available for patients with kidney Yon Su Kim, Kwon Wook Joo, Dong Ki • Translationally controlled tumour protein is associated with podocyte hypertrophy Kim, Hajeong Lee disease. To overcome this, the Kidney Research Center concentrates on patient- in a mouse model of type 1 diabetes. Diabetologia 2012; 55:1205–1217. oriented translational research and basic sciences. Our long-term objective is to • Sulfatide-Reactive Natural Killer T Cells Abrogate Ischemia-Reperfusion Injury. J identify the specific causes of diseases resulting in renal failure to facilitate the Am Soc Nephrol 2011;22: 1305–1314. development of novel diagnostic tools and patient-oriented therapeutic options. • Secretory-Defect Distal Renal Tubular Acidosis Is Associated with Transporter Defect in H-ATPase and Anion Exchanger-1. J Am Soc Nephrol. 2002;13: 1425–1432.

Cardiac Electrophysiology Lab Members of Cardiac Electrophysiology Lab

Atrial fibrillation is the most common arrhythmia in the clinical field. The Cardiac Principal Investigator Electrophysiology Lab of Seoul National University Hospital has focused on Seil Oh, Eue-Keun Choi the mechanism of cardiac arrhythmia, especially for atrial fibrillation, as well as Professor the genetics of arrhythmia. We have studied the role of the cardiac autonomic Myung-Jin Cha Researcher Yon Su Kim nervous system on the development of atrial fibrillation. We founded that the cardiac autonomic nervous system plays an inevitable role in Moo Kang Kim, Ji Yoon Shin, Jee Hee Jang the pathogenesis of atrial fibrillation. We have reported cardiac ganglionated plexi Our four main areas of focus are : as a therapeutic target by modulating using botulinum toxin injection or carvedilol. 1) Development of a wearable artificial kidney: A wearable artificial kidney Our lab has a facility to record autonomic nerve signals in ambulatory canine is designed for dialysis patients who can wear the device to enable greater model, which could be used for studying the mechanism of tachyarrhythmia and mobility, reduce their time on a chair or bed and improve their quality of life. We developing a new therapeutic modality. We also participate in developing wearable intend to apply a new concept of dialysis, ion concentration polarization, for the and self-powered energy sources and a low-power wireless communication system development of our device. We will take advantage of recent medical advances for a pacemaker. Another task is to find genetic risk factors for atrial fibrillation to make a quantum leap in uremia treatment. specific to Koreans. 2) Chip for 3-D micro glomerulus structure reproduction: Because the human glomerulus is a complex organ, the 3-D micro-glomerulus device can provide organ functionality by recapitulating multicellular architecture and physiochemical microenvironments. 3) Precision medicine for kidney disease patients: The main goal is to identify genes that function as biomarkers of the disease and characterize genetic markers that can modulate such genes to ultimately find individual-specific drug targets. Our group is collecting various specimens including micro-dissected glomerular and tubular cDNA samples from percutaneous kidney biopsies. To overcome individual genetic differences, we plan to apply a systems biology approach to integrate genomic and gene expression data. 4) Renal fibrosis inhibition to save kidney function: One of our research interests is progression and potential regression of chronic kidney disease. Kidney fibrosis is the final common pathway in a number of kidney diseases. Several mechanisms are involved in the progression of fibrosis, so detecting the mechanism by which fibrosis develops is recommended, as well as finding ways to prevent or reverse Vol.2 Vol.2 this process. We also seek a therapeutic target for kidney fibrosis. 84

Excellence Excellence 85 Selected Publications ------Finding novel molecule factors to induce endothelial cell transdifferentiation. • Botulinum toxin injection in epicardial autonomic ganglia temporarily suppresses - Discovering new molecules and receptors related to metabolic syndrome. Main research theme vagally mediated atrial fibrillation. Circ Arrhythm Electrophysiol. 2011;4(4):560-5. - Diversity of cardiovascular disease sources derived from induced pluripotent • Effects of carvedilol on cardiac autonomic nerve activities during sinus rhythm stem cell banks. Comprehensive approach to and atrial fibrillation in ambulatory dogs. Europace. 2014 Jul;16(7):1083-91. doi: Cardiovascular Research 10.1093/europace/eut364. Epub 2014 Jan 26. Our detailed interest in stem cell biology is as follows: • Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict - Therapeutic application of endothelial progenitor cells in cardiovascular disease Ablation Success. J Am Heart Assoc. 2015 Aug 13;4(8):e002046. doi: 10.1161/ and unique 3-D ex vivo culture method to expand them efficiently. National Research laboratory for cardiovascular stem cell JAHA.115.002046. - Useful methods for differentiation and culture of mesenchymal stem cells, an ($2Million Project) • Left ventricular pacing with long pulse duration can avoid phrenic nerve excellent non-tumorigenic source of stem cell therapy, from human embryonic - Cellular network / interaction between cardiovascular cells stimulation. Heart Rhythm. 2011;8(10):1637-40. stem cells or human umbilical cord blood stem cells. - Regulating mechanisms in adult vascular • Quantification of cardiac autonomic nervous activities in ambulatory dogs by - Utilization of inducible pluripotent stem cells made by the dedifferentiation and cells eliminating cardiac electric activities using cubic smoothing spline. Physiol Meas. reprogramming of somatic cells; redifferentiation of inducible pluripotent stem cells - Identification of stem cells for cell therapy - Gene therapy, biopolymer therapy 2012 Feb;33(2):131-45. doi: 10.1088/0967-3334/33/2/131. Epub 2012 Jan 6. to various somatic cells can be used for cell therapy in cardiovascular disease. - Stem cell physiology

Innovative Research We have achieved notable results in both basic and clinical research on the Institute for cell therapy ($20 Million subjects mentioned above with systematic and well-organized approaches, and Project) Development of cardiovascular regeneration published our findings in international peer-reviewed journals. In this day, we still therapies using stem/progenitor cells Cardiovascular Stem Cell Laboratory Members of thrive on our research on stem cells and cardiovascular biology to accomplish our Cardiovascular Stem Cell ultimate goal: curing patients with life-threatening diseases. Vascular Biology Laboratory Laboratory Mechanism of Restenosis The ultimate goal of our study is to develop a unique and substantial strategy of Adipocytokines and Atherosclerosis applying stem cells for the treatment of cardiovascular disease. To accomplish this Pleiotrophic effect of statins Principal Investigator Cell signaling in vascular cells goal, our lab studies the development and progression of cardiovascular disease Hyo-soo Kim

Differentiation CARDS Bank (DNA and Serum Bank) to discover potential therapeutic targets. In addition, we also explore new culture Professor single cell suspension culture with EB media induction EB formation GWAS of CAD methods of stem cells, mechanism of stem cell differentiation and their application Yoo-Wook Kwon, Han-Mo Yang, Chang- Genetic Susceptibility to vasospasm in clinical settings. So the focus of our research can be classified into cardiovascular Hwan Yoon, Sang-eun Lee, Eun Ju Lee, Pharmacogenomics Genetic risk factors of disease and stem cells. Hyun-Jai Cho, Hyunduk Jang, Jung-Kyu stent thrombosis

Han, Jin Hur Differentiation Details of the areas of our research interest in cardiovascular disease is as follows:- single cell suspension culture with EB media induction EB formation New molecules and their receptors that affect atherosclerosis development and Beating cells progression that can be potential therapeutic targets.

Research Focus Differentiation single cell suspension culture with EB media induction

EB formation

Beating cells Induced Pluripotent Stem Cells MAGIC Cell Trial (Myocardial Regeneration and Angiogenesis in Myocardial Infarction with G-CSF and Intra-Coronary Stem Cell Infusion)

G-CSF injection Bone marrow Direct Mobilization and homing of stem cells

single cell Adult somatic cells Beating cells suspension (fibroblasts) Intracoronary

culture with EBDifferent iation single cell suspension culture with EB media induction EB formation media G-CSF injection infusion of stem cells Differentiation Differentiation single cell suspension culture with EB media induction single cell suspension culture with EB media induction Apheresis EB formation EB formation

Beating cells We tested Clinical feasibility and Effects of G-CSF induced mobilization and - Mechanism of restenosis development in a Taxol-eluting stent and novel additional intra-coronary infusion in patients with myocardial infarction. methods to prevent it, as well as development of a new conceptual stent with Clinical Research and Trial Experience less stent thrombosis with less restenosis. MAGIC Cell Trial Program: Series of ‘proof of concept’ trials COREA Trial: Bench to bedside example - Mechanisms and therapeutic prospects of vascular calcification. CILON-T Trial EXCELLENT Trial Beating cells EB formation Differentiation Beating cells ES-like cells - Pathophysiology of myocardial edema and its impact on myocardial damage Beating cells HOST-ASSURE Trial: Largest domestic clinical trial ever (3,750 patients)

Vol.2 Vol.2 induction after myocardial infarction and its therapeutic significance. 86

Excellence Excellence 87 Selected Publications ------• CD82/KAI1 maintains the dormancy of long-term hematopoietic stem cells Laboratory of Breast Cancer Biology Members of through interaction with DARC-expressing macrophages. Cell stem cell in press. Laboratory of Breast Cancer • Direct Conversion of Adult Skin Fibroblasts to Endothelial Cells by Defined Biology Factors. Circulation 2014 published online September 3, 2014 [IF=15.221] • Adenylyl Cyclase-Associated Protein 1(CAP1) is a Receptor for Human Resistin Principal Investigator and Mediates Inflammatory Actions of Human Monocytes. Cell Metabolism Hyeong Gon Moon 2014 Mar 4;19(3):484-97. [IF=17.565] Researcher Bok Sil Hong, Jiwoo Lee, Hyun Hye Moon, • Vascular calcifying progenitor cells possess bi-directional differentiation Seol Hwa Jo, Saem Hur, Jin Hui Jo potentials. PLOS Biology 2013 April | Volume 11 | Issue 4 | e1001534. [IF=11.55] • Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. EMBO Molecular Medicine 2012; 4: 1–15 [IF=10.15]

Laboratory of Ocular Regenerative Members of (1) Role of breast cancer microenvironment Laboratory of Ocular (2) Drug resistance and novel therapeutic targets Medicine and Immunology Regenerative Medicine and (3) Breast cancer PDX model Immunology

Our research scope includes 1) Principal Investigator Selected Publications ------understanding pathophysiology Mee Kum Kim, Joo Youn Oh • The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in related to ocular surface Professor Breast Cancers. Plos One/10(12)/e0143811. regeneration and immunology Won Ryang Wee • Prognostic and functional importance of the engraftment-associated genes in and 2) development of novel Researcher the patient-derived xenograft models of triple-negative breast cancers. Breast therapeutics based on basic Jae Young Kim, Yu Jeong Kim, Hyo Kyung Cancer Research and Treatment/154(1)/pp13-22. Lee, Hyun Ju Lee, Jung Hwa Ko, Hyun science. • Reduced proliferation in breast cancer cells contacting the neighboring Jeong Jeong, Jin Suk Ryu, Se Yeon Park, adipocytes in human breast cancer tissues. Breast Cancer Research. 17:90. Seung Hee Han • NFIB is a potential target for estrogen receptor-negative breast cancers. Mol Oncol. 5(6):538-44. Selected Publications ------• Phosphorylation of p90RSK is associated with increased response to neoadjuvant • Mesenchymal stem/stromal cells precondition lung monocytes/macrophages chemotherapy in ER-positive breast cancer. BMC Cancer. 10;12:585. to produce tolerance against allo- and autoimmunity in the eye. Proc Natl Acad Sci USA. 2016 Jan 5;113(1):158-63. • Mesenchymal stem/stromal cells protect against autoimmunity via CCL2- dependent recruitment of myeloid-derived suppressor cells. J Immunol. 2015 Apr 15;194(8):3634-45. The research-driven hospital Members of • Blockade of CD40-CD154 costimulatory pathway promotes long-term survival of administration department The research-driven hospital full-thickness porcine corneal grafts in nonhuman primates: clinically applicable administration department xenocorneal transplantation. Am J Transplant. 2015 Mar;15(3):628-41. The research-driven hospital administration department is in charge of research- Hee Chan Kim, Saram Lee, Eun Ju Kim, • Mesenchymal stem/stromal cells protect the ocular surface by suppressing driven activities at SNUH. In 2013, SNUH was selected as a research-driven Myung Geun Song, Ah Reum Kim inflammation in an experimental dry eye. Mol Ther. 2015 Jan;23(1):139-46. hospital, and in 2014, research-driven hospital administration department was • Mesenchymal stem/stromal cells inhibit the NLRP3 inflammasome by founded to increase support for R&D and for systematic management of activities decreasing mitochondrial reactive oxygen species. Stem Cells. 2014 related to research-driven hospital project(supported by Ministry of Welfare and Jun;32(6):1553-63. Health-MOWH). The research-driven hospital administration department monitor current status of general research-related current status in SNUH such as total research activities, achieved research results and research network between Vol.2 Vol.2 external agencies. 88

Excellence Excellence 89 And It supports the planning and promotion of new activities. Between some common research topics at SNUH including cancer, inflammation&metabolism, hybrid medical equipment, neuroscience, and biotherapeutics, the department Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic is especially concentrated on peptide receptor 2 (NPR2) gene supporting research for cancer, inflammation &metabolism. Furthermore, project management policy was implemented such that 3 Ph.Ds and 2 administrations Identification of the Npr2 mutation. personnel are solely focused on the management of these projects. In order Am J Med Genet A. 2014 Jan;164A(1):156-63 to achieve high standards of research and for successful results, the research- driven hospital administration department holds numerous committees and self- evaluation meetings. Additionally, the department also frequently opens symposiums and educational Schematic workflow used in this study. Genetics in Medicine (2016) 18, 563–569 programs (SNUH R&D seminars), and sends out newsletters to publicize research

results and to increase networking for researchers. The research-driven hospital Patient

administration department is located on the 1st floor room number 1203 at the - Clinical findings - Radioligic findings Center for Medical Innovations. -Lab findings Clinical diagnosis

Category Ⅰ Category Ⅱ Category Ⅲ Category Ⅳ Category Ⅴ

Sanger Targeted exome sequencing for hotspot(s) No sequencing Laboratory of Genetic Skeletal Anomaly Members of Yes Prioritization

Laboratory of Genetic Skeletal Candidateseq. var. Anomaly The majority of musculoskeletal disease is thought to have a genetic Confirm No by Sanger sequencing background. Especially, congenital skeletal anomaly is strongly associated Principal Investigator Yes with genetic abnormalities. Our laboratory focus is the genetic diagnosis and Tae-Joon Cho Previously pathomechanism of genetic skeletal anomalies. Furthermore, we strive to Professor Yes reported elucidate the function of specific genes in the development of skeletal disease. In-Ho Choi, Won Joon Yoo, No Segregation study Dong Yeon Lee Molecular diagnosis Compatible Not compatible Researcher Confirmed Highly likely Less likely No candidate Selected Publications ------Lee Hye Ran • Comprehensive genetic exploration of skeletal dysplasia using targeted exome Alternare methods WES/WGS, aCGH, sequencing. Genet Med. 2015 Sep 24. MPLA, karyotyping, ISH etc. • Acromesomelic dysplasia, type maroteaux caused by novel loss-of-function mutations of the NPR2 gene: Three case reports. Am J Med Genet A. 2016 Feb;170(2):426-34. • A single recurrent mutation in the 5’-UTR of IFITM5 causes osteogenesis imperfecta type V. Am J Hum Genet. 2012 Aug 10;91(2):343-8. • Novel COL2A1 variant (c.619G>A, p.Gly207Arg) manifesting as a phenotype Laboratory of Emergency Medical Services similar to progressive pseudorheumatoid dysplasia and spondyloepiphyseal dysplasia, Stanescu type.Hum Mutat. 2015 Oct;36(10):1004-8. • Whole-exome sequencing identifies mutations of KIF22 in spondyloe- Emergency medicine involves providing medical care to patients with pimetaphyseal dysplasia with joint laxity, leptodactylic type. Am J Hum Genet. illnesses or injuries requiring immediate care. including initial resuscitation and 2011 Dec 9;89(6):760-6. stabilization in the acute phase. The Laboratory of Emergency Medical Services (LEMS) of the Biomedical Research Institute at Seoul National University Hospital was founded in December 2010 with a research team housed under Vol.2 Vol.2 the Department of Emergency Medicine of the hospital. Our lab is organized 90

Excellence Excellence 91 Selected Publications ------Members of • Effect of therapeutic hypothermia on the outcomes after out-of-hospital cardiac Laboratory of Emergency arrest according to initial ECG rhythm and witnessed status: A nationwide Medical Services observational interaction analysis. / Resuscitation / Volume100 / 51-59. • Dispatcher-assisted bystander cardiopulmonary resuscitation in a metropolitan city: Principal Investigator A before–after population-based study / Resuscitation / Volume 85 / Pages 34-41. Sang Do Shin • Extracorporeal life support and survival after out-of-hospital cardiac arrest in Professor a nationwide registry: A propensity score-matched analysis. / Resuscitation / Kyoung jun Song, Seung Chul Lee, Seung Volume99 / page 26-32. Sik Hwang, Ki Ok Ahn, Dae Han Wi, Kyung • Association between resuscitation time interval at the scene and neurological Won Lee, Sang Chul Kim, Yu Jin Kim, Chu Hyun Kim, Taeyun Kim, Hyun Wook outcome after out-of-hospital cardiac arrest in two Asian cities / Resuscitation / Ryoo, Hyun Ho Ryu, Sungwoo Moon, Ju Volume 85 / Pages 203-210. Ok Park, Eui Jung Lee, Joong Sik Jeong, • Outcomes for out-of-hospital cardiac arrests across 7 countries in Asia: The into the five research sections shown below with the mission to expand our Jin Seong Cho, Won Chul Cha, Ki Jeong Pan Asian Resuscitation Outcomes Study (PAROS) / Resuscitation / Volume 96 emergency medical knowledge and develop technology for the safety and Hong, Joo Yeong Kim, Young Sun Ro, / Pages 100-108. health of the community to service anyone at anytime and anywhere. Sung Wook Song, Joo Jeong, Kwang Soo Bae, Yu Jin Lee, Wonpyo Hong - The Pre-Clinical Research Section(PCR) aims to improve the methods of Researcher So Yeon Kong, Soo Jin Kim, Sola Kim, Tae preventing premature death and reducing associated disabilities in patients Han Kim, Gwan Jin Park, Yong Joo Park, suffering from sudden cardiac arrest and severe trauma, through large animal Laboratory of Transplantation Immunology Members of Jeong Ho Park, Kyoung Min Sun, Seung resuscitation models to test safety and efficacy and developing novel medical Laboratory of Transplantation Min Jeong, Young Hee Jung, Myeong Jae Immunology device technology. Choi, Jungeun Kim, Ilwoong Woo, Nayoung Kim, Seung Hyun Kim, Chaewon Principal Investigator - The Education, Simulation and Intervention Research Section(ESI) is committed Kim, Ji Soo Park, Sora Song, Young Jin Curie Ahn to studying intervention and implementation strategies of emergency medical Oh, Juyeon Inez Lee, Jun Nyeong Lim, Ho Research Professor service(EMS) devices and pre-hospital care intervention through simulation and Jung Jang, Myoung Gyo Jung, Minji Kwon, Hyunho Kim education. This section’s primary research areas include sudden cardiac arrest, Ji Young Shin, Hyo Sik Eom, Ye Won Kang Researcher major trauma, acute myocardial infarction and acute stroke. Eun Mi Lee, Sunghoon Hurh, Alam Md Zahid, Min Jung Kim, Hyunho Kim, - The Prehospital System Monitoring Section(PSM) oversees the systematic Youngmi Choi, Hyunsuk Kim management of Korea’s pre-hospital EMS system through a specialized monitoring and evaluation process. This section also contributes to the development of systemic and operational healthcare policies.

- The Environment, Disaster and Global EMS Section(EDGE) seeks to provide effective and safe EMS in times of a public health crisis through active research, We focus on 1) research defining the mechanisms underlying graft rejection education and training. Its primary research areas include responding to climate of the allotransplantation(pig to pig) and xenotransplantation (pig to monkey) change, evaluation of healthcare accessibility in developing countries, devising models and development of therapeutics that could give hope to patients at the methods to maintain the highest quality of emergency preparedness and global end stage of organ failure and 2) finding mechanisms for cystogenesis of poly- healthcare policies. cystic kidney disease and development of a new therapeutic drug.

- The Research Support and Education(RSE) Section aims to improve the quality S e l e c t e d P u b l i c a t i o n s ------of research by providing methodological support from the early design stage • Clinical Correlates of Mass Effect in Autosomal Dominant Polycystic Kidney to dissemination of findings, including preparation of study proposals, data Disease. PloS One. 2015 Dec 7 management and analysis, and manuscript writing. • Human thrombomodulin regulates complement activation as well as the coagulation cascade in xeno-immune response. Xenotransplantation. 2015 Jul- The five research sections participate in research projects including national Aug; 22(4): 260-72. registries for cardiac arrest and major trauma, surveillance and more for achieving our • Increased urinary Angiotensinogen/Creatinine (AGT/Cr) ratio may be associated Vol.2 Vol.2 mission of providing quality emergency care to anyone at anytime and anywhere. with reduced renal function in autosomal dominant polycystic kidney disease 92

Excellence Excellence 93 patients. BMC Nephrology. 2015 Jun 20; 16: 86. • Production and characterization of soluble human TNFRI-Fc and human HO- Members of 1(HMOX1) transgenic pigs by using the F2A peptide. Transgenic Res. 2014; 23 Human Brain Function (3): 407-19. Laboratory • Korean Organ Transplantation Registry Study Group: Initial report of the Korean Organ Transplant Registry: the first report of national kidney transplantation Principal Investigator data. Transplant Proc. 2014; 46 (2) : 425-30. Chun Kee Chung Professor June Sic Kim, Seung Hyun Jin Researcher Hyeongrae Lee, Manyoel Lim, Hong Gi Human Brain Function Laboratory Yoem, Chan Hee Kim, Woorim Jeong, Woojin Choi, Soyeon Jun, Seokyun Ryun, Dahye Kim, Sojeong Lee, Mikyung Choe, Elok Pratiwi, Eunjeong Jeon, Tae Hyung Kim

This lab studies the functions of the human brain and neural mechanisms via various measuring methods of brain activity such as MRI, fMRI, EEG, and ECoG, PET. Furthermore, we also carry out research on patients with neurological disease to improve their quality of life by diagnosing and curing them.

Neuropathic pain : We clarify the mechanism of pain perception and modulation by finding structural and functional brain abnormalities of patients suffering from chronic pain.

Epilepsy : We study the features of brain networks of epileptics, causes of seizure and the region where it starts to improve surgical outcomes for drug refractory epileptics.

Brain-machine interface : This technology controls a robot or computer Music : The spatial complexity and temporal properties of music are studied, and by identifying human intentions based on measurement and analysis of the theoretical aspects of music are scientifically identified. electromagnetic changes in the brain. Memory : We study brain networks associated with memory and brain stimulation techniques for treating patients with memory disorders.

Selected Publications ------• Altered white matter integrity in corpus callosal area in fibromyalgia identified with tract-based spatial statistical analysis. Arthritis Rheumatol. 2014 Sep 15. doi: 10.1002/art.38771. • Mesial temporal lobe epilepsy with hippocampal sclerosis is a network disorder with altered cortical hubs. Epilepsia. 2015 May;56(5):772-9. doi: 10.1111/ epi.12966. • Estimation of the velocity and trajectory of three-dimensional reaching movements from non-invasive magnetoencephalography signals. J Neural Eng. Vol.2 Vol.2 2013 Apr;10(2):026006. doi: 10.1088/1741-2560/10/2/026006. 94

Excellence Excellence 95 • Melody effects on ERANm elicited by harmonic irregularity in musical syntax. Brain Res. 2014 Apr 29;1560:36-45. doi: 10.1016/j.brainres.2014.02.045. Walking kinematics for the 1st and 2nd visit • Episodic memory in aspects of large-scale brain networks. Front Hum Neurosci. 2015 Aug 14;9:454. doi: 10.3389/fnhum.2015.00454. eCollection 2015.

Flex/Ext Rotation Foot Progression

Hallux

Laboratory of Human Motion Analysis Members of Flex/Ext Pro/Sup Rotation Laboratory of Human Motion Analysis Hindfoot

3-D motion analysis of human motion has been used by clinics for pre- and Principal Investigator Arch Height Arch Length Arch Index post-operative assessment of functions in several diseases such as cerebral Won Joon Yoo

palsy, meningomyelocele, brain and spinal injuries, and sports trauma. We Professor Arch focus on the functional analysis of human motion and try to develop a treatment In-Ho Choi, Tae-Joon Cho, protocol based on functional assessment. Furthermore, our research focuses on Dong Yeon Lee Flex/Ext Pro/Sup Rotation the relationship between motion analysis and sports performance.

Forefoot Selected Publications ------• Validity, reliability, and responsiveness of the Korean version of American Flex/Ext Pro/Sup Rotation Academy of Orthopedic Surgeons Foot and Ankle questionnaire.J Foot Ankle Medial Surg. 2015 Jan-Feb;54(1):46-50. forefoot • Correlation between static radiographic measurements and intersegmental

angular measurements during gait using a multisegment foot model.Foot Ankle Flex/Ext Pro/Sup Rotation Int. 2015 Jan;36(1):1-10. Lateral • Negative-pressure wound therapy induces endothelial progenitor cell forefoot mobilization in diabetic patients with foot infection or skin defects.Exp Mol Med. 2013 Nov 15;45:e62. 1st visit 2nd visit • Demineralized Bone Matrix Injection in Consolidation Phase Enhances Bone Regeneration in Distraction Osteogenesis via Endochondral Bone Formation. Clin Orthop Surg. 2015 Sep;7(3):383-91. • Repeatability of a multi-segment foot model with a 15-marker set in healthy adults. J Foot Ankle Res. 2014 Apr 22;7:24. Clinical Cognitive Neuroscience Center (CCNC)

Marker placement of a 3D multi-segment foot model with 15-marker set

The Clinical Cognitive Neuroscience Center (CCNC) studies human cognitive functions. Its aim is to study unknown fundamental mechanisms of cognitive brain functions, and based on the findings, develop effective treatments for brain disorders such as schizophrenia and obsessive compulsive disorder (OCD). Vol.2 Vol.2 Through comprehensive understanding of human cognition, we want to 96

Excellence Excellence 97 contribute to maintaining public mental health and enhancing human health and life. Our lab uses various types of neurocognitive functional tests and Members of Laboratory of Spinal Research Members of neuroimaging techniques such as MRI, PET and EEG/ERP to study the Clinical Cognitive Laboratory of Spinal Research neurobiological mechanism of various cognitive processes of patients and Neuroscience Center (CCNC) healthy subjects. Recently, one study used DTI/DWI analysis to identify changes Bone and cartilage metabolism Principal Investigator in white matter in thalamo-prefrontal connections in a clinically high risk group Principal Investigator research on clinical spinal diseases, Chun Kee Chung Jun Soo Kwon Professor for schizophrenia [Fig. 1]. including osteoporosis and spinal Professor Sung Bae Park, Chi Heon Kim To study the neural mechanisms involved in the perception of biological tumors. Sung Nyun Kim, Tae Young Lee, Researcher motion for psychosis, fMRI techniques were utilized to observe the specificity Je-Yeon Yun Yoon Jin Lee, Minyoung Hong of brain regions responsive to biological motion perception in individuals with Researcher schizotypal personality disorder [Fig. 2]. Through these methods, we seek to Minah Kim, Jun Hee Lee, Seo Young identify the mechanisms of human cognition including those of common mental Kim, Sanghoon Oh, William Sohn, Eun disorders like schizophrenia and OCD. Chung Noh, Ye Seul Shin, Kang Ik Cho, Selected Publications ------Another goal is to grasp structural and functional abnormalities that involve Youngwoo Yoon, Ji Yoon Seol, Seo Yeon • Bone mineral density changes after ovariectomy in rats as an osteopenic model causation or vulnerability to certain mental illnesses or high risk or prodromal Kwak, Da Hye Bae, Tak Hyung Lee, : stepwise description of double dorso-lateral approach. J Korean Neurosurg population. We also study the effects and mechanisms of related medications Yoo Bin Kwak, Tak Wan Kim, Woo Jung Soc. 2010;48:309-12. through pharmacological approaches like PK/PD modeling & simulation. In Hwang, Hye Rim Oh, Jee Hyung Suh, Min • Strategies of spinal fusion on on osteoporotic spine. J Korean Neurosurg Soc addition to looking for ways to improve impaired cognitive function, we also Hee Lee, Hyun A Kim, Bo Ram Yoo 2011;49 (6):317-322. seek to invent and simulate an ameliorating program. • BMP-2 induced early bone formation in spine fusion using rat ovariectomy osteoporosis model. Spine J. 2013. ct;13(10):1273-80. Selected Publications ------• The time-dependent effect of ibandronate on bone graft remodeling in an • Biological Motion Perception, Brain Responses, and Schizotypal Personality ovariectomized rat spinal arthrodesis model. Spine J. 2014 Aug 1;14(8):1748-57 Disorder. JAMA Psychiatry. 73(3):1-9. 2016. • Effect of a selective estrogen receptor modulator on bone formation in • The effects of pharmacological treatment on functional brain connectome in osteoporotic spine fusion using an ovariectomized rat model. Spine J. 2016 Jan obsessive-compulsive disorder. Biological psychiatry. 75(8), 606-614. 2014. 1;16(1):72-81 • Altered Thalamo-Cortical White Matter Connectivity: Probabilistic Tractography Study in Clinical-High Risk for Psychosis and First-Episode Psychosis. Schizophrenia bulletin, sbv169. 2015. • The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging. Social cognitive and affective neuroscience, 8(1), 27- 33. 2013. • Altered serotonin transporter binding potential in patients with obsessive- Postop. 1 day 3 wks 6 wks 9 wks 12 wks compulsive disorder under escitalopram treatment:[11 C] DASB PET study. Psychological medicine, 46(02), 357-366. 2016. Sham OVX BMP Vol.2 Vol.2

Excellence Excellence 99 • Auditory brainstem responses to CE-Chirp® stimuli for normal ears and those with sensorineural hearing loss. Int J Audiol. 2015;54(10):700-4. Laboratory of Molecular Biology & Members of • Differences in perilymphatic space enhancement and adverse inflammatory Laboratory of Molecular Auditory Electrophysiology Biology & Auditory reaction after intratympanic injection of two different gadolinium agents: A 9.4-T Electrophysiology magnetic resonance imaging study. Hear Res. 2016 Jan 13;333:118-126.

Principal Investigator Seung-ha Oh Professor Jun Ho Lee, Moo Kyun Park, Laboratory of Neurodegenerative Disorder Members of Laboratory of Myung Whan Suh Neurodegenerative Disorder Researcher Jae Joon Han, Jihye Rhee, Jeong Sug Principal Investigator Kyong, Tae Soo Noh, Yujung Hwang, Our lab studies and develops cure strategies for neurodegenerative disorders by Manho Kim Eun Bit Bae, Jun Jae Choi, Doo Hee Kim, activating autophagy or mitophagy. Huntington’s Disease (HD) is an inheritable Professor Jeong Ah Cho, So Hyeon Park, Na Hyun disorder characterized by the progressive degeneration of neural cells in various Wooseok Im Kim parts of the brain. Symptoms include involuntary muscle movement, cognitive Researcher disorder and dementia. The disease is caused by a mutation in the gene that Jiyoung Shim, Min-Jung Oh, Hyun-Jung codes for protein huntingtin. The instability of long polyglutamine region in the Park, Hyeran Park, Mijung Lee, Jeong-hun first exon contributes to the formation of the mutant huntingtin, a known cause Nam gung Cochlea and vestibular organs are composed of various kinds of cells, but their of neurodegeneration. exact functions have not been explored. Through the application of molecular Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder and biology and electrophysiology, we seek to find out the function of each cell the most common form of senile dementia. Its pathologies are neuronal and in the inner ear. Our lab focuses on the identification and characterization of synaptic loss, senile plaques and neurofibrillary tangles in the cerebral cortex. the ion channels of the inner ear by using a voltage-sensitive vibrating probe Autophagy is a cellular degradation pathway for the clearance of damaged or technique, whole-cell patch clamp and various molecular biology including superfluous proteins and organelles. It prevents the gradual accumulation of immunohistochemistry. damaged proteins and organelles, thus playing an important role in protein and We are specifically interested in the epithelial cells of Reinssner’s membrane organelle quality control. and Caludius cells. In addition to a gene study to detect gene mutations and Mitophagy is a form of selective autophagy specific to degradation of damaged discover new hearing-related genes, research on the mechanisms of hearing mitochondria in the lysosome. It maintains quality of the mitochondria by loss have been performed at the gene level. In animal models using an ion eliminating damaged mitochondria. Since neurodegenerative disease is channel-KO mouse and deafened cat, hearing change after insult such as commonly caused by dysfunctional mitochondria, cellular oxidative stress, noise exposure and the development of a new electrode design for cochlear autophagic alterations and protein aggregation, autophagy and mitophagy implantation have been studied, respectively. could be strategies to fight the disease.

Selected Publications ------Selected Publications ------• Effects of congruent and incongruent visual cues on speech perception and brain • Neurogenic Effects of Cell-Free Extracts of Adipose Stem Cells. PLOS activity in cochlear implant users. Brain Struct Funct. 220(2)/1109-25/2016. ONE/11(2): e0148691. • Factors Contributing to Speech Performance in Elderly Cochlear Implanted Patients: • Multidrug resisrance protein 1 reduced the aggregation of mutant huntingtin in An FDG-PET Study: A Preliminary Study. J Int Adv Otol. 11(2)/98-103/2015. neuronal cells derived from the Huntington’s disease R6. 2 model/SCIENTIFIC • Optimal ossicular site for maximal vibration transmissions to coupled REPORTS/2015;5:16887. transducers. Hear Res. 2013 Jul;301:137-45. • Neuroprotective Effect of Human Adipose Stem Cell-Derived Extract in Amyotrophic Lateral Sclerosis/Neurochemical Reseatch/10.1007/s11064-015- 1774-z. • Seasonal Variation, Cranial Autonomic Symptoms, and Functional Disability in Migraine: A Questionnaire-Based Study in Tertiary Care/ HEADACHE/2015;55:1112-1123. • Extracts of Adipose Derived Stem Cells Slows Progression in the R6/2 Model of Huntington’s Disease/PLOS ONE/8(4): e59438. Vol.2 Vol.2

100

Excellence Excellence 101 Laboratory for Sepsis and Resuscitation Members of Laboratory of Cutaneous Aging and Hair Members of Laboratory for Sepsis and Laboratory of Cutaneous Resuscitation Research / Dermatology Aging and Hair Research / Our purpose is to improve the Dermatology prognosis of patients with sepsis and Principal Investigator Principal Investigator post-cardiac arrest syndromes. We Gil Joon Suh Professor Jin Ho Chung, Kyu Han Kim, study the mechanisms of inflammatory Woon Yong Kwon, Kyoung Su Kim Ohsang Kwon responses and oxidative damage Researcher Professor during sepsis and global ischemia- Sung Hee Kim, A Reum Lee, Kwang Hyun Cho, Soyun Cho, Seong Jin reperfusion injury, and the therapeutic Jeong Yeon Kim, Yoon Sun Jung, Jo, Dong Hun Lee, Chong Won Choi, Je- effects of candidate materials on the identified target pathophysiology to Min Ji Park, Tae Gyun Kim, Jung-In Ko, Ho Mun, Hyun-Sun Yoon, Hyun Sun Park improve the prognosis of sepsis and post-resuscitation patients. Particularly, our work is focused on the role of pharmaconutrient agents that modulate intracellular signaling pathways dependent on the reactive oxygen species. We are also developing new devices for cardiopulmonary resuscitation (CPR) that can provide effective CPR in cardiac arrest victims.

S e l e c t e d P u b l i c a t i o n s ------• Niacin and Selenium Attenuate Sepsis-Induced Lung Injury by Up-Regulating “Global Leader in Dermatological Research” Nuclear Factor Erythroid 2-Related Factor 2 Signaling. Crit Care Med Our lab is committed to finding the causes of various skin diseases and achieve 2016;44(6):e370-82. breakthroughs in their treatment. About 40 researchers including professors, • Plasma glutathione reductase activity and prognosis of septic shock. J Surg postdoctoral researchers, medical doctors and specialists in genetics and Res 2016;200(1):298-307. biochemistry as well as dermatology are devoted to our world-class research. We • Prolonged therapeutic hypothermia is more effective in attenuating brain have achieved several remarkable breakthroughs, especially in skin aging and apoptosis in a Swine cardiac arrest model. Crit Care Med 2014;42(2):e132-42. hair research. Our lab is Korea’s best skin institute, and our goal of becoming the • Niacin suppresses the mitogen-activated protein kinase pathway and attenuates world’s best is led by the motto “From clinic to bench, and back again.” brain injury after cardiac arrest in rats. Crit Care Med 2013;41(9):e223-32. • The effect of glutamine on cerebral ischaemic injury after cardiac arrest. Special focus Resuscitation 2013;84(9):1285-90. Skin aging We study aging-related changes and their mechanisms to discover the cause of skin aging to eventually develop a groundbreaking approach for the prevention and treatment of human aging (intrinsic aging and photoaging). Hair & stem cell We aim to identify the causes of hair disease and develop new treatment methods. We are conducting extensive basic research on hair stem cells including iPS, development, differentiation, hormonal factors, immune system and pharmacology. Atopic dermatitis We have conducted basic and clinical research on atopic dermatitis and skin barrier. More recently, our focus is on translational research to elucidate the causes of atopic dermatitis and other allergic diseases. Pigmentary disorders We aim to elucidate the causes of various pigmentary disorders such as vitiligo, melasma and graying hair and develop new treatment modalities. Homepage: http://iheib.snu.ac.kr

S e l e c t e d P u b l i c a t i o n s ------• Adiponectin Deficiency Contributes to Sensitivity in Human Skin. J Invest Dermatol. 2015 Sep;135(9):2331-4. • Endogenous estrogen exacerbates UV-induced inflammation and photoaging in Vol.2 Vol.2 mice. J Invest Dermatol. 2014 Aug;134(8):2290-3. 102

Excellence Excellence 103 • Development of a model for chemotherapy-induced alopecia: Profiling of histological changes in human hair follicles after chemotherapy. J Invest Laboratory of Diabetic & Ischemic Foot Members of Dermatol 2016 ;136(3):584-92. Laboratory of Diabetic & • Hair growth-promoting effects of adiponectin in vitro. J Invest Dermatol. 2012 Disease Ischemic Foot Disease Dec;132(12):2849-51. • Clinical pearls from atopic dermatitis and its infectious complications. Br J Diabetic foot diseases include infection, ulcer, gangrene and deformities of Principal Investigator Dermatol. 2014 Jul;170 Suppl 1:25-30. the foot, which are caused by both peripheral polyneuropathy and peripheral Dong Yeon Lee Researcher microangiopathy. Our lab focuses on the role of angiogenic stem cells in Ji Hye Kim collateral circulation in both diabetic and ischemic foot disease. We try to develop protocols to assess the function of angiogenic stem cells in patients with diabetic or ischemic foot disease and enhance the formation of collateral circulation to improve clinical outcomes.

S e l e c t e d P u b l i c a t i o n s ------• Demineralized Bone Matrix Injection in Consolidation Phase Enhances Bone Regeneration in Distraction Osteogenesis via Endochondral Bone Formation. Clin Orthop Surg. 2015 Sep;7(3):383-91. • Negative-pressure wound therapy induces endothelial progenitor cell

Representative photographs of sun-exposed skin in a 25-year-old subject (A) and a 77-year-old subject (B). C, Chronically sun-exposed, left, and mobilization in diabetic patients with foot infection or skin defects. Exp Mol sun-protected, right, skin of a 76-year-old individual.(Arch Dermatol. 2002;138(11):1437-1442) Med. 2013 Nov 15;45:e62. • Photoplethysmography and continuous-wave Doppler ultrasound as a complementary test to ankle-brachial index in detection of stenotic peripheral arterial disease. Angiology. 2013 64(4):314-20. • Application of the Ilizarov technique to the correction of neurologic equinocavovarus foot deformity. Clin Orthop Relat Res. 2011 469(3):860-7. • Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man. Bone. 2010 46(3):673-9.

Clinical manifestation of photoaging and intrinsic skin aging. From Journal of Dermatological Science Supplement, Volume 2, Issue 1, 2006, S13–S22

a Cph100 Control Day3 Day6 Day9 Day12 Day15 Day18

b Cph150 Control Day3 Day6 Day9 Day12 Day15 Day18 Induction of collateral circulation during distraction osteogensis

A B C 1.4

1.2

0.8

0.6

0.4 Expression of tyrosinase-related protein 1 in the model for chemotherapy-induced alopecia. Hair follicle damage response pathways were 0.2 observed, namely dystrophic anagen (Cph100) and catagen (Cph150) pathways. (J Invest Dermatol. 2016 ;136(3):584-92) 0 2w 3w 6w 9w Vol.2 Vol.2

104

Excellence Excellence 105 Research and Development Center of In Members of QuantaMatrix Members of Research and Development QuantaMatrix The Smart Co., Ltd. Center of In The Smart Co., Ltd. QuantaMatrix has commercialized molecular and microbiological diagnostic President services enabled by proprietary instrumentation and internally developed Sunghoon Kwon Principal Investigator In The Smart Co., Ltd. develops disposable kits. Recent developments include three proprietary and cutting Kang Uk cutting-edge medical devices edge platforms. Researcher based on optical and medical Il Hyung Shin, Choong Hee Lee, imaging and IoT technologies Ki Jung Kim with the world-class medical team at Seoul National University Hospital.

S e l e c t e d P u b l i c a t i o n s ------• Study of operation dynamics for crystal temperature measurement in a diode endpumped monolithic Yb:YAG laser. • A high brightness Q-switched oscillator and regenerative amplifier based on a dual-crystal Yb:KGW laser. • Power limitations and pulse distortions in an Yb : KGW chirped-pulse amplification laser system • Application of Yb:KGd(WO4)2 crystals to lasers with high brightness beams. • dRAST (Direct Rapid Antibiotic Susceptibility Test) in 4~6 hours • Femtosecond laser based on Yb:KYW crystals with suppression of spectral dRAST is the fastest AST platform and can identify optimal antibiotics within just 4~6 narrowing in a regenerative amplifier by spectral profiling of the pulse. hours after a positive blood culture, while other conventional systems take 2-3 days.

0 20 40 60

Conventional Blood Culture Pure Culture AST 60Hours

24 hours dRASTTM Blood Blood Culture dRASTTM SAVE TWO DAYS 24Hours

24 hours dRASTTM Urine/Swab Pure Culture dRASTTM 24Hours 4~6 hours

• DST for tuberculosis (drug susceptibility test) in one week QuantaMatrix DST performs a rapid DST in just a week from positive TB culture samples using our patented microfluidic and time-lapse imaging technologies.

Conventional DST Confirmation of TB positive

4 Weeks 4 Weeks is needed to get DST result

QMAC-DST END point of DST Confirm

4 Weeks 1 Week 3 Weeks SAVE

• Multiplex diagnosis platform QMAP QuantaMatrix develops encoded magnetic microdisk manufacturing technologies Vol.2 Vol.2 to provide multiplex assay solutions for all kinds of analytes. 106

Excellence Excellence 107 Seoul National University Hospital Research Biomedical Research Institute Statistics Vol.2 Vol.2

108

Excellence Excellence 109 Excellence Vol.2 SCI Journals Reseach Funds 1,000 1,500 2,000 2,500 3,000 500 17.5 23.8 2.2 0 43.7 2010 Total 2000 483

0.2

2001 506

28.6

21.0

2.4 2002 593 52.1 2011 Total

2003 627 0.1

2004 656 27.8 26.3

2.5 1,065

2005 56.8 2012 Total

2006 999 0.2

2007 1,126 26.6 32.5 2.7

1,419 2008 62.0 2013 Total

0.3 2009 1,472

■ 1,807 SNUHFunds 2010 26.3 39.2 3.1

68.8 2014 2011 Total 1,948

■ 0.2

Sponsor 2,205 2012

39.9

30.6 2,416 2013 3.0 ■ Government 73.8 2015

Total

2014 2,493 0.2

(milion USD) 2,787

(years) 2015 ■ PMS Clinical Trials SIT Current StateofClinicalMFDSTrials Approval: 100 125 150 100 150 200 250 300 25 50 75 50 0 0 + ■ Thecatholic university ofkorea, SeoulST. Mary’s Hospital. IIT InstitutionComparison 29 2010 2011 51 83 ■ SeoulNationalUniversity Hospital 2011 36 2012 54 91 2012 ■ BundangNationalUniversity Hospital 39 ■ SamsungMedical Center 2013 58 115 2013 51 ■ AsanMedical Center 2014 56 2014 ■ ChonbukNationalUniversity Hospital 150 ■ phase1 ■ phase2 ■ Severance 49 2015 2015 61 102 133 224 239 243 253 47 ■ phase3

143 Hospital

111 110 Excellence Vol.2 Collaboration withSNUHCTC DevelopedbyDomesticCompaniesin New Drugs no. 25 24 23 22 21 20 19 18 17 16 15 14 13 12 11 10 1 2 3 4 5 6 7 8 9 Product Sunpla Easyef Milican Quroxin Factive Apitoxin Camtobell Revanex Suganon Sivextro Inj Sivextro Tab Zabolante Acelex Gv1001 Duvie Zemiglo Supect Caps Zepeed Pyramax Kanarb Noltec Mvix Pelubi Levovir Zydena Sponsor Sk Chemiclas Daewoong Dongwha Pharm Jw Pharmaceutical Lg LifeSciences Guju Chong KunDang Yuhan Dong-A St Dong-A St Dong-A St Donghwa Pharm Crystalgenomics Gemvax &Kael Chong KunDang Lg LifeSciences Il-Yang Pharm Jw Pharmaceutical Shin Poong Boryung Il-Yang Pharm Sk Chemiclas Daewon Bukwang Pharmaceutical Dong-A Approval(KFDA) 1999.07 2001.05. 2001.07. 2001.12. 2002.12. 2003.05. 2003.10. 2005.09. 2015.10. 2015.04. 2015.04. 2015.03. 2015.02. 2014.09. 2013.07. 2012.06. 2012.01. 2011.08. 2011.08. 2010.09. 2008.10. 2007.07. 2007.04. 2006.11. 2005.11. Seoul NationalUniversityHospitalScientificAward Award Ham ChunChang-uiAward Young Researcher Award Myung Choo-wanAward Shim Ho-seopAward Ji Seok-youngAward 2014 Bang, Yung Jue Lee, EunBong Hahn, SeoKyung Keam, BhumSuk Seok, SeungHyeok Yun, Young Ho Cho, BeLong Kang, GyeongHoon Lee, MyungChul Kim, DongWan Im, SeockAh Park, KiHo Chung, ChunKee Lee, JeongMin 2015 Kang, HyoungJin Jeong, SeungYong Yoon, JeongHee Lee, JeongHoon Jang, JinYoung Park, ChangMin Oh, Seung-June Kim, Sun-Whe Yu, HyeongGon Lee, DongSoo Kim BoongNyun Kim, JeongHun Jeon, BeomSeok 113 112 Excellence Vol.2 Shared FacilitiesinCenterforMedicalInnovation No 27 26 25 24 23 22 21 20 19 18 17 16 15 14 13 12 11 10 36 35 34 33 32 31 30 29 28 9 8 7 6 5 4 3 2 1

Article Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Electronic(Macro) Balance, Electronic(Macro) Balance, Electronic Balance, Electronic Balance, Electronic Balance, Electronic Balance, Electronic Balance, Electronic Balance, Electronic Balance, Electronic Balance, Electronic Balance, Electronic Automated CellCounter Automated CellCounter Automated CellCounter Automated CellCounter Analytical Balance Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical

Manufactur Fisher Fisher Fisher Fisher Fisher Fisher Ohaus Ohaus Ohaus Fisher Cas Mettler Toledo Mettler Toledo Mettler Toledo Mettler Mettler Mettler Toledo Mettler Mettler Mettler Toledo Ohaus Mettler Toledo Bio-Rad Bio-Rad Bio-Rad Bio-Rad Ohaus Fisher Ohaus Ohaus Ohaus Fisher Ohaus Ohaus Fisher Fisher er

Model B 1900-19 B 1900-19 B 1900-19 B 1900-19 B 1900-19 B 1900-19 02-037-Sd 02-037-Sd 02-037-Sd B 1900-19 Mw Ii-300 Ml802 Pg802-S Toledo Pb303 Pb303 Pb602-S Pb303 Pb303 Pb403-S/F31 Os-E12130 Xs105 Du Tc10 AutomatedCellCounter Tc20 Tc20 Tc20 - 02-037Sd 02-037-Sd 02-037-Sd 02-037-Sd B 1900-19 02-037-Sd 1550Sd 02-037Sd 02-037Sd

Name Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room No 37 63 62 61 60 59 58 57 56 55 54 53 52 51 50 49 48 47 46 45 44 43 42 41 40 39 38 72 71 70 69 68 67 66 65 64

Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bead Bath Bead Bath Bead Bath Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Balance, Mechanical Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Article

Manufactur Thermo Thermo Thermo Thermo Thermo Thermo Thermo Thermo Thermo Thermo Thermo Labconco Thermo-Fisher Thermo-Fisher Thermo-Fisher Lab Armor Lab Armor Lab Armor Ohaus Ohaus Ohaus Fisher Fisher Fisher Ohaus Fisher Fisher Thermo Thermo Thermo Thermo Thermo Thermo Thermo Labconco Thermo er

1367 1367 1367 1367 1367 1367 1367 1367 1367 1367 1367 Logic 1376 1376 1376 La74220-720 La74220-720 La74220-720 02-037-Sd 1550Sd 1550Sd 02-037Sd 02-037Sd 02-037Sd 02-037-Sd B 1900-19 B 1900-19 1367 1367 1367 1367 1367 1367 1367 Logic 1367 Model

Name Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room 115 114 Excellence Vol.2 No 100 114 113 112 111 110 109 108 107 106 105 104 103 102 101 99 98 97 96 95 94 93 92 91 90 89 88 87 86 85 84 83 82 81 80 79 78 77 76 75 74 73

Article Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated) Cell ImagingAnalysisSystem Bio-Molecular Imager Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Bio SafetyCabinet Centrifuge(Mini) Centrifuge(Mini) Centrifuge(Micro,Ref) Centrifuge(Micro,Ref) Centrifuge(Micro,Ref) Centrifuge(Micro, Refrigerated) Centrifuge(Micro, Refrigerated) Centrifuge(Micro, Refrigerated) Centrifuge(Micro, Refrigerated) Centrifuge(Micro, Refrigerated) Centrifuge(Imbalance-Tolerant DriveUltracentrifuge) Centrifuge(High Speed,Refrigerated) Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated) Centrifuge(Benchtop, Refrigerated)

Manufactur Thermofisher Thermo Thermofisher Thermofisher Thermofisher Eppendorf Eppendorf Eppendorf Gmbh Tissuegnostics Ge Thermo-Fisher Labconco Thermo Thermo Thermo Thermo Thermo Thermo Thermo Thermo-Fisher Thermo Thermo Thermo Thermo Thermo Thermo Thermo Fisher Fisher Hettich Hettich Hettich Hanil Science Hanil Science Hanil Science Hettich Hanil Science Beckman Beckman Thermofisher Thermo Thermo er

Model Megafuge 40R 75004518 Megafuge40R 75004518/Megafuge 40R 75004518/Megafuge 40R 75004518/Megafuge 40R 5810R 5810R 5810R Tissuequest4.0 Las-4000Mini 1376 Logic 1367 1367 1367 1367 1367 1367 1367 1376 1367 1367 1367 1367 1367 1367 1367 05-090-129 05-090-129 Micro 22R Micro 22R Micro 22R Micro 17Tr Micro 17R Micro 17R Mikro 22R Micro 17R Xl-90 J-301 Megafuge 40R 75004518 Megafuge40R 75004518 Megafuge40R

Name Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room No 157 156 155 154 153 152 151 150 149 148 147 146 145 144 143 141 140 139 138 137 136 135 134 133 132 131 130 129 128 127 126 125 124 123 122 121 120 119 118 117 116 115 142

Co Co Co Co Co Co Co Co Co Co Co Co Co Co2 Incubator Co Co Clean Bench Clean Bench Chemiluminescence Centrivap MobileSystem Centrivap MobileSystem Centrifuge, Micro Centrifuge, Micro Centrifuge, Micro Centrifuge, Micro Centrifuge, Micro Centrifuge, Micro Centrifuge(Tabletop,Refrigerated) Centrifuge(Tabletop,Refrigerated) Centrifuge(Tabletop, Refrigerated) Centrifuge(Tabletop, Refrigerated) Centrifuge(Tabletop, Refrigerated) Centrifuge(Table Top, Refrigerated) Centrifuge(Super Vacuum, Refrigerated) Centrifuge(Refrigerated) Centrifuge(Multipurpose, HighSpeed) Centrifuge(Mini) Centrifuge(Mini) Centrifuge(Mini) Centrifuge(Mini) Centrifuge(Mini) Centrifuge(Mini) Co Article 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator

Manufactur Thermo Thermo Thermo Fisher Thermo Fisher Thermo Fisher Heraeus Heraeus Heraeus Heraeus Eppendorf Eppendorf Eppendorf Eppendorf Thermo Heraeus Heraeus Boyung Electronics Hansol Cellbiosciences Fisher Fisher Eppendorf Gyrozen Eppendorf Gyrozen Eppendorf Eppendorf Beckman Beckman Thermo Thermo Thermo Beckman Sci Vision Eppendorf Beckman Fisher Fisher Fisher Fisher Fisher Fisher Heraeus er

Heracell 150I Heracell 150I Heracell 150I Heracell 150I Heracell 150I Heracell 150 Heracell 150 Heracell 150 Bb15 Galaxy170 Galaxy170 Galaxy170 Galaxy170 Heracell 150I Heracell 150 Heracell 150 Bk-Lcb Sw-140 Vs Flurochem Hd2 Spd2010-220 Spd2010-220 5424R 1730R 5424R 1730R 5424R Eppendorf 5424 Gs-6R Gs-6R 75004518 Megafuge40R 75004518 Megafuge40R 75004518 Megafuge40R Allegra X-12R Vs-30000 5810R Allegra 21R 05-090-129 05-090-129 05-090-129 05-090-129 05-090-129 05-090-129 Heracell 150 Model

Name Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room 117 116 Excellence Vol.2 No 181 180 179 178 177 176 175 174 173 172 171 170 169 168 167 166 165 164 163 162 161 160 159 193 192 191 190 189 188 187 186 185 184 183 182 158 194 196 195 197

Article Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Dry Bath Dna ThermalCycler Cytocentrifuge Co Dry BathIncubator 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator Incubator / O 2

Incubator Manufactur Memert Memert Memert Heraeus Eppendorf Eppendorf Thermo Thermo Thermo Thermo Thermo Thermo Thermo Heraeus Memert Memert Memert Memert Memert Heraeus Eppendorf Eppendorf Thermo Memert Memert Heraeus Eppendorf Eppendorf Eppendorf Eppendorf Eppendorf Eppendorf Eppendorf Thermo Memert Memert - Hoffer - Fisher er

Model Inc 153Med Inc 153Med Inc 153Med Heracell 150 Galaxy170 Galaxy170 Heracell 150I Heracell 150I Heracell 150I Heracell 150I Heracell 150I Heracell 150I Heracell 150I Bb15 Inc 153Med Inc 153Med Inc 153Med Inc 153Med Inc 153Med Heracell 150 Galaxy170 Galaxy170 Heracell 150I Inc 153Med Inc 153Med Heracell 150 Galaxy170 Galaxy170 Galaxy170 Galaxy170 Galaxy170 Galaxy170 Galaxy170 Heracell 150I Inc 153Med Inco 108 Alb64 Ptc-200 Cytopro7620 11718

Name Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility No 224 223 222 221 220 219 218 217 216 215 214 213 212 211 210 209 208 207 206 205 204 203 202 201 200 199 198 239 238 237 236 235 234 233 232 231 230 229 228 227 226 225

Image Analyzer Image Analyser Hot-Plate-Stirrer Hot-Plate-Stirrer Hot-Plate-Stirrer Hot-Plate-Stirrer Hot PlateStirrer Hot PlateStirrer Hot PlateStirrer Hot PlateStirrer Homogenizer(Automill) Homogenizer High CapacityRotorSystem Heat Sealer Harvard Trip(Ohaus) Gel DryingSystem Gel Dryer Fume Hood Fume Hood Fume Hood Fume Hood Fume Hood Freeze Dryer Freeze DrySystem Fluorescence Microscope, Inverted Electronic Balance Dry Bath(Digital,Shaker) Micro Centrifuge Inverted Microscope WithDigitalCamera Inverted Microscope Inverted Microscope Inverted Microscope Inverted Microscope Inverted Microscope Inverted Microscope Inverted Microscope Inverted Microscope Inverted Microscope Inverted Microscope Inverted Microscope Incubator ShakingOrbital Incubator ShakingOrbital Article

Manufactur Bio-Rad Seoulin Bioscienc Fisher Fisher Fisher Vision Hanil Fisher Talboys Hanil Tokken Fisher Beckman - Ohaus Biorad Fisher Greenpuretech Greenpuretech Greenpuretech Greenpuretech Sugong Labconco Labconco Leica Mettler Toledo Eppendorf Eppendorf Leica Leica Leica Leica Leica Leica Leica Olympus Leica Olympus Olympus Leica Jeio Tech Jeio Tech er

Gel Doc Sl-20 1150049Sh 1150049Sh Labtamp Kmc-13Osh Hms-Ii Cimarec 984Ta7chseua Hms-Ii Tk-Am5 Powergen125 Rotor - 1560-Sd 165-1790 Fb-Gd-Xi Gfa-120 Gfa-130 Gfa-150 Gfa-120 D11-1200-Sm Freezone 6Plus 7755042 Dmil Led/Dfc450c Ml802 Thermomixer Comport5355 5424R Dmil-Led/Dfc295 Leica DmilLed/Dfc295 Dmil/Dfc290 Dm Il Leica DmilLed/Dfc295 Dmil Led/Dfc295 Leica DmilLed/Dfc295 Ix50-121 Leica DmilLed/Dfc295 Ix50-12 Ck40-22Php Dmil/Dfc295/Af6000 Si-900R Si-900R Model

Name Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility 119 118 Excellence Vol.2 No 240 251 250 249 248 247 246 245 244 243 242 241 266 265 264 263 262 261 260 259 258 257 256 255 254 253 252 267 282 281 280 279 278 277 276 275 274 273 272 271 270 269 268

Article Microplate Reader(Vis) Microplate Reader(Vis) Microplate Reader(Vis) Microplate Reader(Vis) Microplate Reader(Uv/Vis) Microcentrifuge(Refrigerated) Micro Centrifuge,Refrigerated Micro Centrifuge,Refrigerated Micro Centrifuge(Refrigerated) Micro Centrifuge Micro Centrifuge Ph Meter Ph Meter Ph Meter Ph Meter Ph Meter Microwave Range Microwave Range Microwave Range Microwave Oven Microscope, MultiView Microscope, Binocular Microscope, Binocular Microscope, Binocular Microscope, Binocular Microscope, Binocular Microprocessor-Controlled UvCrosslinker Shaking Water Bath Shaking Water Bath Shaking Incubator Shaking Incubator Safety StorageCabinet Rocker Rocker Rocker Refrigerator Refrigerator Refrigerated Circulation Bath Reagent SafetyCabinet Printer Ph Meter Ph Meter Ph Meter

Manufactur Molecular Device Molecular Device Molecular Device Molecular Device Molecular Device Thermo Beckman Beckman Eppendorf Eppendorf Beckman Fisher Fisher Fisher Eutech Fisher - - Samsung Samsung Olympus Olympus Olympus Olympus Leica Olympus Spectronics Fisher Jeio Tech Jeio Tech Jeio Tech Justrife Boekel Scientific Boekel Scientific Boekel Scientific Chang ShinTech Chang ShinTech - Toga Hp Fisher Eutech Fisher er

Model Versamax Versamax Versamax Versamax Spectramax190 Fresco 21 Microfuge 22R Microfuge 22R 5415R 5424R Microfuge 18 Xl150 13636Xls Xl15 Ph6000 Xl15 27L 27L Re-C20dv Re-449R Bx51t-32E01 Ch30 Ch3213e Ch3213e Dm2500 Ch3213e Xl-1500 154555 Swb-10 Si-300R Si-300R 894520 260350 260350 260350 Sgrr-72Gd-Pmr Sgrr-72Gd-Pmr Rcb 300 Toga-Gs02 Hp-3005 Ecph1500 Ph6000 Ecph1500

Name Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility Cell Culture Room Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility No 309 308 307 306 305 304 303 302 301 300 299 298 297 296 295 294 293 292 291 290 289 288 287 286 285 284 283 325 324 323 322 321 320 319 318 317 316 315 314 313 312 311 310

Twister Twister Twister Twister Thermoblock InSitu Thermal Cycler Thermal Cycler Thermal Cycler Thermal Cycler Thermal Cycler Thermal Cycler Spectrophotometer, Microplate Spectrophotometer, Microplate Spectrophotometer(Nano Drop) Sonic Dismembrator Sonic Dismembrator Sonic Dismembrator Sonic Cleaner Shaking Water Bath Shaking Water Bath Shaking Water Bath Shaking Water Bath Shaking Water Bath Shaking Water Bath Shaking Water Bath Shaking Water Bath Shaking Water Bath Water Bath Water Bath Water Bath Water Bath Vortex Mixer Vortex Mixer SpectrophotometerUv/Vis System SpectrophotometerUv/Vis System SpectrophotometerUv/Vis System SpectrophotometerUv/Vis SpectrophotometerUv/Vis Ultrasonic Cleaner Ultrasonic Cleaner Ultrasonic Bath(Bransonic) Ultracentrifuge Twister Article

Manufactur Vision Sci Vision Sci Vision Sci Vision Sci Vision - Bio-Rad Bio-Rad Bio-Rad Biometra Biometra Bio-Rad Biotek Biotek Thermo Fisher Fisher Cosmobio Fisher Polyscience Jeio Tech Jeio Tech Sci Vision Jeio Tech Jeio Tech Jeio Tech Memmert - Jeio Tech Jeio Tech Jeio Tech Jeio Tech Fisher Sci Vision Nd1000 Beckman Nd1000 Shimazu Beckman Branson Branson Bransonic Beckman Talboys er

Vs-96Tw Vs-96Tw Vs-96Tw Vs-96Tw - Ptc200 S1000 S1000 T3000 T3000 S1000 Epoch Epoch Nd-2000 550 #15-338-550 Bioruptor(Krb-01) 120V 11Qt/Timer Wds20 Swb-10 Swb-10 Kmc-1205Sw1 Swb-10 Swb-10 Bs-06 Wne45 M01 Swb-10 Wb-20E Wb-20E Wb-20E Wb-20E #12-812 Kmc-1300V - Du-800 - Uv-1800 Du 650 M1800h 1533722K 5800 Optima L-100K 1000Ws Model

Name Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Cell Culture Room Cell Culture Room Shared Facility Shared Facility Cell Culture Room Cell Culture Room Cell Culture Room Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility Shared Facility 121 120 Excellence Vol.2 Laboratory Principal Investigators Cartilage and Stem Cell Cartilage andStemCell Thyroid Research Lab Infection &Immunity Nanobiotechnology Research Center Sensory Organ Osteoarthritis, Laboratory of Laboratory of of Innovative Laboratory Research

Name Jeong, Han-Gil Kim, Yerim Kim, ChiKyung Lee, Seung-Hoon Bae, HyunCheol Nam, BoMi Yang, Haru Wang, SunYoung Park, HeeJung Han, Hyuksoo Lee, Sahnghoon Lee, MyungChul Kong, SungHye Song, Young Shin Jung, GyeongSeo Kim, HwanHee Sun, HyunJin Kim, MinJoo Cho, SunWook Park, Young Joo Park, DoJoon Park, Wan Beom Kim, NamJoong Oh, Myoung-don Choi, Su-Jin Choe, PyoengGyun Bae, EunBit Kim, NaHyun Park, SoHyeon Kim, DooHee Cho, JeongAh Hwang, Yujung Noh, Tae Soo Yu, youngmi Kyong, Jeong-Sug Rhee, Jihye Han, JaeJoon Suh, MyungWhan Park, MooKyun Lee, JunHo Oh, Seung-ha Kim, Hang-Rai

Degr M.Sc. M.D. M.D. Ph.D. M.Sc. B.S. B.S. M.Sc. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D. M.D. M.Sc. M.Sc. M.Sc. M.D. M.D. M.D. M.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.Sc. M.D., M.Sc. B.S. Ph.D., B.S. M.Sc. B.S. B.S. B.S. B.S. M.D. M.Sc. M.Sc. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.Sc. M.Sc. M.D., Ph.D. ee Laboratory Diabetes and Metabolic Diabetes andMetabolic Research Laboratory Nanobiotechnology Neuronal StemCell of BrainTumor and Stroke Transitional Disease Research Glioma Research Neurosurgical Laboratory of Laboratory of Laboratory of Laboratory of of Innovative Laboratory Andrology Research

Jung, HyeSeung Cho, Young Min Park, KyongSoo Kang, Dong-Wan Han, JuHee Kim, SongI Park, EunSun Ki, SeulKi Choi, InYoung Son, Hyoshin Yang, Wookjin Kim, DoYeon Paick, Jae-Seung Park, MinJung Chowdhury, Tamrin Choi, Anna Kim, SoJin Dho, Yun-Sik Se, Young-Bem Kim, JinWook Park, Chul-Kee Chai, JiSun Cho, MinChul Kim, SooWoong Yoon, Byung-Woo Jung, EunSun Kang, MinKyoung Nam, Kiwoong Mo, Heejung An, SangJoon Kim, Tae Jung Kang, LaMi Sun Jing Yang, Xiu-Li Kim, Young-Ju Ko, Sang-Bae Paek, SunHa Choi, Yousik Lee, Jooyoung Kim, Yona Hwang, HeyMin Moon, HyoEun Name

M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. B.S. B.S. B.S. B.S. B.S. M.Sc. B.S. B.S. B.S. M.D., Ph.D. B.S. B.S. M.Sc. Ph.D. M.D. M.D. ,M.Sc. M.D., Ph.D. M.D., Ph.D. M.Sc. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. B.S. M.D. ,M.Sc. B.S. M.D. ,M.Sc. M.D. ,M.Sc. M.D. ,M.Sc. B.S. M.D. ,M.Sc. M.D. ,M.Sc. B.S. M.D., Ph.D. M.D., Ph.D. B. Sc. B. Sc. B. Sc. M.Sc. Ph.D. Degr ee Laboratory Laboratory of Diabetic / Laboratory ofDiabetic/ Diabetes and Metabolic Diabetes andMetabolic Ischemic FootDisease Motor neuron disease Clinical andResearch Amyotrophic lateral Rheumatic Disease Disease Research and CellTherapy Laboratory for Laboratory of Laboratory of sclerosis/

Kim, jiHye Lee, DongYeon Choi, JiYong Kang, ShinEui Kim, JeungYeon Lee, JooYoun Yoo, HyunJung Park, JinKyun Lee, EunYoung Lee, EunBong Song, Yeong Wook Kim, BoJung Shim, Yu Mi Kim, Yoo Li Lee, SungWoong Choi, SeokJin Ahn, SoHyun Choi, KyoMin Baek, SeolHee Kim, JunSoon Kim, KiYoon Jeon, GyeSun Lee, HeeWoo Shin, JeYoung Kim, SungMin Hong, Yoon Ho Sung, JungJoon Ahn, ChangHo Lim, JiHye Kim, MiNa Kang, Yu Mi Shen, HaiYing Choi, EunHye Jang, MiGyeong Nan Jinyan Lee, JiSeon Choi, JinWoo Koo, Young Do Lee, HakMo Chung, SungSoo Kwak, SooHeon Name

B.S. M.D., Ph.D. M.Sc. M.Sc. M.Sc. Ph.D. M.Sc. M.D. M.D. M.Sc. M.D. B.S. B.S. M.Sc. M.Sc. M.Sc. M.Sc. M.Sc. M.Sc. M.Sc. M.D. M.D. M.D. M.Sc. M.D. M.D. M.D. M.D. B.S. B.S. M.Sc. M.D., Ph.D. B.S. B.S. M.Sc. M.Sc. Ph.D. Ph.D. Ph.D. Ph.D. M.D., Ph.D. Degr ee Medicinefor Otorhinolary- Laboratory Bioinspired Regenerative Retinal Degeneration Research Laboratory Urological Oncology Rheumatic Disease (FARB) Laboratory Related Blindness BiRO (Laboratoryof Bioengineering Angiogenesis- Laboratory of Laboratory of Laboratory of Laboratory of Reproductive Reproductive Fight against ngologicfield) Genetics (RDRL)

Ku, JaHyeon Kwak, Cheol Kim, HyeonHoe Kim, JongMi Hong, MinA Hwang, KyuRi Kim, JinJoo Choi, Young Min Lee, ByungJoo Cho, ChangSik Song, HyunBum Park, SungWook Jo, DongHyun Jun, HyoungOh Kim, JinHyoung Kim, JeongHun Lee, MiAe Kim, ChungHwan Min, Haejun Cho, KyungMee Kim, Yoon Young Ku, Seung-Yup Park, JungBum Ma, DaeJoong Kim, Young joo Ghim, Woon Hyung Cho, InHwan Shin, JooYoung Park, UnChul Yu, HyeongGon Kim, InGul Chung, EunJae Quan, Yongjun Lee, HyeSun Kang, Minyong Lee, KyoungHwa Jeong, ChangWook Kwon, SeongKeun Park, JiSoo Shon, SeHui Song, JiEun Name

M.D. M.D. M.D. B.S. M.Sc. M.D. M.D. M.D. M.D. M.Sc. M.D. M.D. M.D., Ph.D. Ph.D. Ph.D. M.D., Ph.D. B.S. B.S. B.S. M.Sc. Ph.D. M.D. B.S. B.S. M.Sc. B.S. M.Sc. M.Sc. M.D. M.D. M.D. M.D. M.Sc. B.S. M.D. M.D. M.D. M.D. B.S. B.S. B.S. Degr ee 123 122 Excellence Vol.2 Laboratory Reconstructive Surgery Tissue Engineeringand Medicinefor Otorhinolary- Bioinspired Regenerative Institute ofPlasticand Pediatric Neurology BiRO (Laboratoryof Pediatric Urology Medical Devices Application Lab Plastic Surgery Laboratory for Laboratory of Laboratory of Biomaterials ngologicfield) Processing Research (RIPRS) &

Name Im, Young Jae Park, Kwanjin Kim, HyunJung Lee, RyunSuk Hong, KiYong Kim, ByungJun Kim, SangWha Jin, UngSik Chang, Hak Minn, KyungWon Kwon, SungTack Choi, Eunjung Kim, Young Min Park, Geeho Jeon, Byoungjun Ha, Cheolmin Piao, Yinglan Wufuer, Maierdanjiang Hur, Woojune Choi, Tae Hyun Jeon, BeomSu Kwak, JiMin Ji, HanBi Nam, DongYeon Shin, ByungHo Ko, SongAh Lee, JaeYeon Cho, Yong Chan Kim, SeNa Huh, BeomKang Kim, ByungHwi Kim, MyungHun Lee, SeungHo Choy, Young Bin Kim, SooYeon Lee, SangJee Cho, HaNa Han, MiJung Ahn, HeeJin Kim, Minjeong Cho, Anna Lee, Jinsook Lim, ByungChan Kim, KiJoong Chae, Jong-Hee Park, HyeJin Lee, SunHee

Degr M.D. M.Sc. B.S. M.D., Ph.D. M.D., M.Sc. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.Sc. M.Sc. B.S. B.S. M.Sc. M.Sc. M.Sc. M.Sc. M.D. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. Ph.D. Ph.D. Ph.D. Ph.D. Ph.D. M.D. B.S. B.S. M.Sc. M.Sc. M.D. B.S. M.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. B.S. B.S. M.Sc. ee Laboratory Laboratory ofNeonatal Transplantation and Pediatric Neurology and Developmental Neurorehabilitation Electrophysiology Cerebrovascular Data MiningLab Kidney Disease & Regenerative Health System Laboratory for Neurosurgery Laboratory of Laboratory of Laboratory of Medicine Diseases Pediatric Cardiac Biology Lab

Joo, KwonWook Kim, Yon Su Lee, KyungYeop Shin, SeungHan Kim, Ee-Kyung Kim, Han-Suk Bang, MoonSuk Heo, EunYoung Kwon, Bo-mi Min, JaeWon Lee, JinJu Lee, SeungHak Seo, HanGil Jung, SeHee Oh, Byung-Mo Lee, Shi-Uk Chung, SunGun Kim, JeongEun Ha, EunJin Cho, Won-Sang Kang, HyunSeung Lee, Hajeong Kim, DongKi Oh, Seil Jang, JeeHee Shin, JiYoon Kim, MooKang Cha, Myung-Jin Cho, Youngjin Choi, Eue-Keun Park, Soojin Lee, Young Eun Lee, ChanHee Jangra, Anshika Kwak, PilAe Moon, Youn Joo Lee, MyeongSuk Choi, SeungAh Phi, JiHoon Wang, Kyu-Chang Kim, Seung-Ki Seo, Boram Park, SangMin Kim, Kyuwoong Jung, Go-Un Lee, Donghoon Kim, Sugyeong Name

M.D., Ph.D. M.Sc. M.Sc. Ph.D. Ph.D. M.D., Ph.D.s M.Sc. B.S. B.S. B.S. M.D. M.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D. B.S. M.Sc. M.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D. B.S. B.S. B.S. M.Sc. M.Sc. M.D. M.Sc. B.S. B.S. M.Sc. M.Sc. M.Sc. B.S. Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.Sc. Ph.D. M.D., M.PH., B.S. B.S. M.Sc. B.Pharm MD. Degr

ee Laboratory Regenerative Medicine Breast CancerBiology Laboratory ofOcular Medical Services and Immunology Genetic Skeletal Cardiovascular Laboratory of Laboratory of Laboratory of Emergency Laboratory Stem Cell Anomaly

Wi, DaeHan Ahn, KiOk Hwang, SeungSik Lee, SeungChul Song, Kyoungjun Shin, SangDo Lee, HyeRan Lee, DongYeon Yoo, Won Joon Choi, In-Ho Cho, Tae-Joon Jo, JinHui Hur, Saem Jo, SeolHwa Moon, HyunHye Lee, Jiwoo Hong, BokSil Moon, Hyeong Gon Moon, HyeongGon Han, SeungHee Park, SeYeon Ryu, JinSuk Jeong, HyunJeong Ko, JungHwa Lee, HyunJu Lee, HyoKyung Kim, Yu Jeong Kim, JaeYoung Wee, Won Ryang Oh, JooYoun Kim, MeeKum Hur, Jin Han, Jung-Kyu Jang, Hyunduk Cho, Hyun-Jai Lee, EunJu Lee, Sang-eun Yoon, Chang-Hwan Yang, Han-Mo Kwon, Yoo-Wook Kim hyo-soo Ryu, HyunHo Ryoo, HyunWook Kim, Taeyun Kim, ChuHyun Kim, Yu Jin Kim, SangChul Lee, KyungWon Name

M.D. M.D. M.D. M.D. M.D. M.D. M.Sc. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. B.A. B.A. B.A. M.Sc. M.Sc. Ph.D. M.D., Ph.D. B.S. B.S. M.Sc. M.Sc. M.Sc. B.S. B.S. M.Sc. M.Sc. M.D. M.D. M.D. Ph.D. M.D., Ph.D. Ph.D. M.D., Ph.D. Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. Ph.D. M.D., Ph.D. M.D. M.D. M.D. M.D. M.D. M.D. M.D. Degr ee Laboratory Medical Services Transplantation Laboratory of Laboratory of Immunology Emergency

Lee, EunMi Ahn, Curie Lim, JunNyeong Lee, JuyeonInez Oh, Young Jin Song, Sora Kang, Ye Won Eom, HyoSik Shin, JiYoung Kwon, Minji Jung, MyoungGyo Jang, HoJung Park, JiSoo Kim, Chaewon Kim, SeungHyun Kim, Nayoung Woo, Ilwoong Kim, Jungeun Choi, MyeongJae Jung, Young Hee Jeong, SeungMin Sun, KyoungMin Park, JeongHo Park, Yong Joo Park, GwanJin Kim, Tae Han Kim, Sola Hong, Wonpyo Lee, Yu Jin Bae, KwangSoo Kim, SooJin Kong, SoYeon Jeong, Joo Song, SungWook Ro, Young Sun Kim, JooYeong Hong, KiJeong Cha, Won Chul Cho, JinSeong Jeong, JoongSik Lee, EuiJung Park, JuOk Moon, Sungwoo Kim, Hyunho Kim, MinJung Alam, MdZahid Hurh, Sunghoon Name

M.D. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. M.Sc. B.S. B.S. M.Sc. B.S. Ph.D. M.Sc. B.S. M.D. M.Sc. M.Sc. M.D. M.Sc. M.D. M.D. Ph.D. Ph.D. M.D. M.D. M.D. Ph.D. M.D. M.Sc. M.D. M.D. M.D. Ph.D. B.S. M.Sc. M.Sc. M.Sc. Degr ee 125 124 Excellence Vol.2 Laboratory Human MotionAnalysis Human BrainFunction Clinical Cognitive Transplantation Center (CCNC) Neuroscience Laboratory of Laboratory of Immunology Laboratory

Name Kim, Tak Wan Kwak, Yoo Bin Lee, Tak Hyung Bae, DaHye Kwak, SeoYeon Seol, JiYoon Yoon, Youngwoo Cho, KangIk Shin, Ye Seul Noh, EunChung Sohn, William Oh, Sanghoon Kim, SeoYoung Lee, JunHee Kim, Minah Yun, Je-Yeon Lee, Tae Young Kim, SungNyun Kwon, JunSoo Lee DongYeon Cho Tae-Joon Choi In-Ho Yoo Won Joon Kim, Tae Hyung Jeon, Eunjeong Elok Pratiwi Choe, Mikyung Lee, Sojeong Kim, Dahye Ryun, Seokyun Jun, Soyeon choi, Woojin Jeong, Woorim Kim, ChanHee Yoem, HongGi Lim, Manyoel Lee, Hyeongrae Jin, SeungHyun Kim, JuneSic Chung, ChunKee Kim, Hyunsuk Choi, Youngmi Yoo, BoRam Kim, HyunA Lee, MinHee Suh, JeeHyung Oh, HyeRim Hwang, Woo Jung

Degr B.S. M.Sc. B.S. B.S. B.S. M.D. M.D. M.D. M.D. M.D. B.S. B.S. B.S. M.D. M.D. M.Sc. M.D. M.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. Litt. D. M.Sc. M.Sc. M.D. M.D. M.D. M.D. M.D. M.Sc. B.S. B.S. B.S. B.S. B.S. B.S. B.S. B.S. ee Laboratory Laboratory ofSpine and HairResearch/ Neurodegenerative Molecular Biology Electrophysiology Cutaneous Aging Dermatological Laboratory for Resuscitation Laboratory of Laboratory of Laboratory of Laboratory of Sepsis and & Auditory Research Disorder Science

Kim, NaHyun Park, SoHyeon Kim, DooHee Cho, JeongAh Choi, JunJae Bae, EunBit Hwang, Yujung Noh, Tae Soo Kyong, JeongSug Rhee, Jihye Han, JaeJoon Suh, MyungWhan Park, MooKyun Lee, JunHo Oh, Seung-ha Kim, Manho Oh, Min-Jung Shim, Jiyoung Im, Wooseok Ko, Jung-In Kim, Taegyun Park, MinJi Jung, Yoon Sun Kim, JeongYeon Lee, AReum Kim, SungHee Kim, KyoungSu Kwon, Woon Yong Suh, GilJoon Lee, mijung Park, hyeran Chung, JinHo Park, Hyun-sun Yoon, Hyun-Sun Mun, Je-Ho Choi, ChongWon Lee, DongHun Jo, SeongJin Cho, Soyun Cho, KwangHyun Kwon, Ohsang Kim, KyuHan Nam gung,Jeonghun Park, Hyun-Jung Hong, Minyoung Lee, Yoon Jin Kim, ChiHeon Park, SungBae Chung, ChunKee Name

Ph.D. B.S. M.Sc. B.S. B.S. B.S. B.S. B.S. M.D. M.Sc. M.Sc. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D., Ph.D. M.D. M.Sc. B.S. M.D. B.S. B.S. M.D. M.D. M.D. M.D. B.S. B.S. M.Sc. M.D. M.D. M.D. B.S. B.S. M.D. M.D. M.D. M.D. M.D. M.D. M.D. M.D. M.D. M.D. M.D. M.Sc. M.Sc. M.D. M.D. M.D. Degr ee Location Contact Information Medical DeviceInnovationCenter Center forHumanResearch Protection Medical Research CollaboratingCenter Research andCollaboration Department ofTransdisciplinary Animal Research Department ofExperimental SNUH Biobank Department ofResearch &Experiment Clinical Trials Center Administration andCoordination Headquarters ofResearch

Palace Changgyeong

Biomedical Research Institute

Main Gate

Lot Parking

SNUH Clock Tower IRB Administrative office Central Resear Division ofMedicalDeviceUsability T Biomarker Center Division ofIT&Database Division ofExperimentalAnimalResear Administrative Office Clinical Resear Division ofGoodLaboratoryPractice Human Biobank Division ofClinicalDataManagement Division ofBiostatistics Division ofClinicalEpidemiology Division ofNonhumanPrimateResear Brain Bank Cancer TissueBank Division ofPediatricClinicalT Division ofCancerClinicalT

Hospital SNU Dental

ch Laboratory ch SupportOffice

Hospital SNU Children's

Back Gate Center forMedicalInnovation(CMI) rials

rials

esting

ch ch

Station(Line #4) Hyehwa Subway Maroniae Park 02-2072-0694 02-740-8933 02-2072-1888,1981 02-2072-0277 02-2072-1814 02-2072-1614 02-2072-1924,1931 02-2072-1601,1603 02-2072-1655 02-2072-1932 02-2072-1717 02-740-8934,8935 02-740-8938,8939 02-740-8936 02-2072-4753 02-2072-4681 02-2072-2192 02-2072-1989 02-2072-7470 02-2072-7598 SEOUL NATIONAL UNIVERSITY HOSPITAL BIOMEDICAL RESEARCH INSTITUTE

Address Seoul National University Hospital Biomedical Research Institute 71 Daehak-ro Jongno-gu, seoul 03082, Korea

Tel 82-2-2072-1601~3, 1619 Homepage http://bri.snuh.org Publisher Yung-Jue Bang Editor Hyeong-Gon Moon Design & Print Qline