Department of Medicine ANNUAL REPORT July 1, 2019 – June 30, 2020

Department of Medicine

ANNUAL REPORT July 1, 2019 – June 30, 2020

Submitted by: Polly E. Parsons, MD E.L. Amidon Chair and Professor Department of Medicine

Date: September 30, 2020

TABLE OF CONTENTS Section Page Chair’s Executive Summary ...... 3 Department of Medicine Standing Committees ...... 6 Medical Service – UVMMC Practice Sites ...... 17 Department of Medicine Arrived Clinic Visits ...... 17 Graduate Medical Education ...... 20 Cardiovascular Division ...... 28 Dermatology Division ...... 46 Endocrinology Division ...... 52 Gastroenterology & Hepatology Division ...... 61 General Internal Medicine ...... 67 Geriatric Medicine Division ...... 74 Hematology/Oncology Division ...... 77 Hospital Medicine Division ...... 103 Immunobiology Division ...... 111 Infectious Diseases Division ...... 119 Nephrology Division...... 133 Pulmonary and Critical Care Medicine Division ...... 141 Rheumatology and Clinical Immunology Division ...... 163 Research Funding ...... 168

Department of Medicine Annual Report 2019-2020

Chair’s Executive Summary

The Department of Medicine had another incredible and challenging year: We faced the COVID epidemic and the challenges it brought to all aspects of our lives. The creativity, resilience and commitment of the entire department as we continue to face the challenge is truly remarkable. Within days faculty and staff transformed clinical care, education and research and we continued to celebrate the numerous achievements and recognition awards of our faculty, staff and housestaff.

We welcomed 26 faculty over the past year (July 1, 2019-June 30, 2020), with an additional eight faculty already hired to start later in 2020 and early 2021. These faculty have joined the divisions of Cardiology, Dermatology, Endocrinology, General Internal Medicine, Geriatrics, Hematology Oncol- ogy, Hospital Medicine, Pulmonary & Critical Care Medicine, and Rheumatology and are working not only at UVMMC but also in our network affiliate sites. Across the department telemedicine was rapidly incorporated into practice to provide care. The pandemic impact on skilled nursing facilities was profound and our Geriatrics division with support from their colleagues in GIM provided extraordinary compassionate care to their patients in those settings. In the Spring a new clinic was opened for our General Internal Medicine practice in Essex, VT and over the year, as the the number of medicine in-patient beds increased, the Hospital Medicine division expanded and stretched to accommodate the sustained high inpatient census.

Education is a core mission for the department. Faculty continue to teach and mentor in innovative new programs at UVM as well as at our affiliate sites. To further enhance and integrate our education mission, the Education Council, chaired by Kathryn Huggett, PhD., met monthly to review education topics, issues, and initiatives. Faculty continue to be highly engaged in the Teaching Academy: Dr. Amanda Kennedy was recognized as a Distinguished Educator, and Drs. Kelsey Donovan, Eric Ganguly, Emily Hadley-Strout, Jennifer Kelly and Tina Thornton were all inducted as members. Three faculty, Drs. David Chen, E. Rosy Hill and Macaulay Onuigbo completed the 2018-19 Teacher Academy Medical Education Fellowship Program. In recognition of their substantial contributions to education, The Larner College of Medicine Class of 2019 honored Drs. Josh Farkas and David Kaminsky with the Alpha Omega Alpha Honor Society Faculty Award and Drs. Florian Foerg and David Rand with the Clinical Teacher of the Year Award. Dr. Tania Bertsch received the 2019 Frederick Morin Educational Leadership Award and Dr. Richard Pinckney received the CMIE Educator of the Year, 2018-2019: The Department E. L . Amidon recipient was Dr. An- drew Hale and the Mark A. Levine MD Award recipient was Dr. Mohit Jindal. Dr. Patricia King won the Curriculum Innovation Award from the Class of 2022.

The Department continues to be a nationally/internationally recognized leader in research with contributions to new scientific knowledge. The breadth and depth of research throughout our divisions continues to be a testament to our talented investigators. Key grant awards include: Dr. Halle Sobel’s project entitled “Increasing the Pipeline of MAT Prescribers: DATA Waiver Training for All Vermont Medical Students at The Larner College of Medicine”; Dr. Daniel Weiss’s project entitled, “Clinical Development of a Novel Pleural and Tracheal Sealant”; Dr. Ralph Budd’s project entitled “Ligands for Human Synovial Gamma/Delta T Cells”; and Dr. Katharine Cheung’s project entitled “A Randomized Clinical Trial of a Communication Tool to Improve Access to Palliative Care for Patients with End-stage Renal Disease”. Faculty submitted a record number of grant applications this year including twenty- four COVID-19 related proposals since the on-set of the pandemic.

In recognition of their contributions to research Dr. Neil Zakai received the Dean’s Excellence in Research Award (Mid-Career Investigator); Dr. Matthew Poynter received the Dean’s Excellence in Research Award for Research Mentorship; Dr. C. Matthew Kinsey was named the UVMHNMG Junior Researcher of the Year; Dr. Renee Staple- ton was named the UVMHNMG Senior Researcher of the Year; and Dr. Timothy Plante received the Bloomfield Early Career Professorship in Cardiovascular Research. Members of our faculty received new patents and licenses and are the founders of start-ups.

In aggregate, members of the department including students, residents, fellows (MD and PhD) published in high impact journals, as detailed within this report. They were asked to lead and serve on NIH study sections and advisory councils, FDA review panels and editorial boards. They were invited from around the world to present at scientific meetings and to be visiting professors, and they were elected to leadership in national societies. They also received significant recognition from their national and international colleagues: Dr. Glenn Goldman was elected as president of the American College of Mohs Surgery; Dr. Halle Sobel was elected as President, New England Chapter of Society of General Internal Medicine; and Dr. Anne Dixon received the Distinguished Achievement Award from the American Thoracic Society.

For their overall contributions, Dr. Jennifer Gilwee was inaugural winner of the LCOM Dean’s Faculty Award for Professionalism and Dr. Glenn Goldman inducted as the inaugural Rogers and Nancy Follansbee Professor of Medi- cine. It is impossible to list all of the significant contributions of all of our faculty, trainees, students and staff but they can be found throughout this report. Without the incredible dedication, expertise and excellence of our entire department we could not succeed.

Physician Leader and Chair Polly E. Parsons, MD Vice Chairs Education Council Kathryn Huggett, MD Research Charles Irvin, PhD Academic Affairs Benjamin Suratt, MD Quality Allen Repp, MD Director Allen Mead Director, GIM & Geriatrics Tammy Stockton, RN Director, HematologyOncology Jake Hammond Supervisor, Med Ops Support Svcs. Laurie St.Gelais Financial Administrator Jessica Hendela Grants Manager Tina Mazuzan Financial Associate Marlene Frank HR Administrator Bridget Tully Staff Assistant Lisa Pitrowiski

Department of Medicine, University of Vermont Division Chiefs R. Budd, MD, Immunobiology B. Libman, MD, Rheumatology W. Kemper Alston, MD, Infectious Diseases G. Goldman, MD, Dermatology J. Schnure, MD, Endocrinology, Metabolism, & Diabetes B. Littenberg, MD, General Internal Medicine Research J. Gilwee, MD, General Internal Medicine & Geriatrics C. Holmes, MD, Interim, Hematology/Oncology A. Dixon, MD, Pulmonary and Critical Care Medicine D. Schneider, MD, Cardiovascular R. Solomon, MD, Nephrology R. Zubarik, MD, Gastroenterology

Total faculty: 221 By rank – Assistant Professors: 112 Associate Professors: 48 Professors: 53 Clinical Practice Physicians: 6 Faculty Scientists: 2

By gender – 97 female; 124 male By track – Tenured: 25 Research Scholar Pathway: 5 Tenure Pathway: 12 Clinical Scholar Pathway: 164 Education Scholar Pathway: 7 Clinical Practice Physician – 6 Faculty Scientist: 2

Faculty Actions: FALL 2019 – Ten (10) promotions; 8 annual review reappointments SPRING 2020 – 32 full reappointments; 5 annual review reappointments; 10 volunteer pathway faculty reappointments.

Promotions (7/1/20):

Dennis Beatty – to Associate Prof. CSP Narandra Bethina – to Associate Prof. CSP Eric Ganguly – to Professor, CSP Jennifer Gilwee – to Associate Prof. CSP Todd Holmes – to Professor, CSP Amanda Kennedy – to Professor, Edu Prema Menon – to Associate Prof, CSP Cindy Noyes – to Associate Prof. CSP Kristen Pierce – to Professor, CSP Marios Prikis – to Associate Prof, CSP

Department of Medicine – Standing Committees

Medicine Credentials Committee – updated

G. Goldman, Chair A. Dixon, MD M. Lazarovich, MD B. Libman, MD S. Mills, MD K. Pierce, MD S. Reddy, MD H. Rehman, MD D. Schneider, MD J. Schnure, MD R. Solomon, MD

Committee Mission: The mission of the Medicine Credentials committee is two-fold. First, the committee is charged with maintaining an up to date policy and procedure / rules and regulations for the Medicine Health Care Service. Second, the committee is charged with ensuring that faculty receive appropriate initial and ongoing performance evaluations to assist the medical staff office with creden- tialing.

Quality Assurance Committee – Cardiac Catheterization Laboratory – updated P. Gogo, Chair H. Dauerman K. Carey E. Terrien S. Willis (Beausoleil)

Committee Mission: The purpose of the committee is to ensure high quality in the processes of care of the cath lab to ensure excellent outcomes. Some goals are to eliminate outliers, reduce variation, and enhance performance. The QA monthly meeting provides rapid turnover feedback mechanisms. The committee is committed to educational opportunities for the staff and incorporating practice standards and guidelines into the laboratory operation. Internal, regional, and national comparative data is included that address cognitive knowledge, procedural skill, clinical judgment, and procedural outcomes.

Fellowship Directors Education Committee – updated D. Kaminsky, Chair F. Keating N. Ferrentino G. Garrison M. Gilbert P. Gogo B. Libman M. Pasanen K. Pierce P. Spector W. Weise J. Sprague

Committee Mission: The primary mission of the Fellowship Directors’ Education Committee is to provide a forum and improve the training, education and overall experience for all Fellows throughout the UVMMC and to support, and develop the potential of each Fellow; in doing so, the Fellows will become an asset to the medical community providing outstanding care and contributions.

Resident Research Committee – updated A. Kennedy, Chair K. Cheung D. Kaminsky C. Lyon M. Pasanen R. Pinckney J. Sprague D. Weiss N. Zakai

Committee Mission: Responsibilities of the Committee are, in general, to provide guidance and resources for residents and fellows, along with their mentors, performing scholarly research projects. More specifically, the Committee has the following duties: 1) Explain the research project process to new R2s at their annual R2 retreat in July 2) Conduct R2 Research Evenings every fall, where each R2 and their mentor present their project to the Committee to ensure feasibility and receive any pertinent advice/feedback 3) Review residents’ proposals for travel to national meetings to present abstracts that have been accepted, so that limited travel funds can be awarded 4) Serve on a discussion panel for medical students interested in research 5) Review R3 and fellow abstracts every spring to select the abstracts that will be presented orally and via poster on Resident Research Day and Fellow Research Day 6) Select winners of the R3 research (Harriet Dustan) and mentor awards annually for presentation at the resident graduation dinner

Clinical Competency Committee – updated

H. Sobel, Chair J. Bartsch R. Clouser S. Eldakar-Hein C. Farnham R. Murat E. Ganguly F. Keating K. Parker M. Pasanen J. Powelson D. Rand E. Wahlberg K. Wahlberg

Committee Mission: The mission of the Clinical Competency Committee is to ensure that the graduates of our training program have the necessary knowledge, skills and attitudes to provide excellent patient care and to promote quality and improvement in the health care system. The Clinical Competency Committee meets a minimum of twice yearly to assess resident progress towards independent practice using the Milestones as a platform. This committee is responsible for issues pertaining to resident promotion, remediation and dismissal. The committee is also responsible for preparing a complete summative evaluation report, based on a review of all available evaluations, for each resident semi-annually.

Housestaff Selection Committee – updated Shaden Eldakar-Hein, MD - Chair M. Antkowiak J. Bartsch L. Burgess M. Degirmenci F. Foerg E. Ganguly G. Garrison M. Gilbert S. Grant A. Hale N. Hodde W. Hopkins D. Kaminsky C. Lyon R. McEntee P. Menon C. Noyes M. Pasanen

K. Pierce M. Prikis D. Rand A. Repp L. Smith H. Sobel A. Teleron J. Winget

Committee Mission: The Housestaff Selection Committee is responsible for the recruitment of Internal Medicine Residents. This includes a careful review of applications from candidates, interviews of the invited candidates and, finally the compi- lation of the rank list for Match Day. As we receive over 1300 applications for residency, and interview over 200 applicants, this committee serves a critical role in the success of the residency.

Program Evaluation Committee – updated

M. Pasanen, MD - Chair J. Powelson (Chief Resident) E. Wahlberg, MD (Chief Resident) K. Wahlbert (Chief Resident) S. Wayne, MD A. Kumar, MD M. Antkowiak, MD S. Khan, MD B. Depo, MD D. Correa De Sa, MD E. Strout, MD S. Eldakar-Hein, MD A. Hale, MD E. Riser, MD M. Barry, MD J. Bartsch, MD E. Ganguly, MD R. McEntee, MD H. Sobel, MD R. Murat – Program Administrator C. Farnham – Program Administrator

Committee Mission: The Program Evaluation Committee meets 1–2 times per month. This committee actively participates in planning, developing, implementing and evaluating all educational activities of the program. This includes reviewing and making recommendations for revision of competency-based curriculum goals and objectives. It also includes addressing areas of noncompliance with ACGME standards and reviewing the program annually using the evaluations of faculty, residents and others. This culminates in an annual report which summarizes a systematic evaluation of the curriculum and renders the official written Annual Program Evaluation.

Quality Assurance Committee – Medicine Health Care Service – updated

Allen Repp, MD Committee Chair

Allen Mead, MHSA Administration

Pam Stevens, RN, MSN Jeffords Institute for Quality

Amanda Kennedy, PharmD Dept. of Medicine Quality Scholar

Stephen DeVoe, MPH, MS Dept. of Medicine Quality Program Project Director

Peter VanBuren, MD Cardiovascular Medicine

Melanie Bui, MD, PhD Dermatology

Juan Pablo Perdomo Rodriguez, MD Endocrinology and Diabetes

Richard Zubarik, MD Gastroenterology and Hepatology

Michael Latreille, MD General Internal Medicine and Geriatrics

Lynn Wilkinson, D Geriatric Medicine

Farrah Khan, MD Hematology and Oncology

Preetika Muthukrishnan, MD Hospital Medicine Maria Burnett, MD

Timothy Whitman, DO Infectious Disease

Jeffrey Rimmer, MD Nephrology Macaulay Onuigbo, MD

Gil Allen, MD Pulmonary Disease and Critical Care

Scott Legunn, MD Rheumatology and Clinical Immunology

Kramer Wahlberg, MD Chief Residents

LouisBassett Porter, MD Residents

Maria Airoldi, RPh Pharmacy

Susan Bellemare, RN Nursing Julie Morse, RN

Committee Mission:

To monitor, assess and continuously improve the quality and safety of health care provided by the Medi- cine Health Care Service at UVMMC.

Faculty Engagement Committee – updated

J. Kelly, Chair K. Cheung E. Goncharuk F. Khan M. Kokoszynska A. Nevares C. Noyes J. Pierson S. Reddy M. Sandoval T. Thornton M. Zeglin L. Pitrowiski – Admin support

Committee Mission: We are tasked with facilitating interaction between the different divisions in Medicine. We sponsor gatherings at different times of the year and encourage meeting events between divisions. Our goal is to “open up” the department, to encourage inter divisional discourse, and promote mentorship.

Medical Grand Rounds Education Program Committee – updated

R. Budd, MD C. Irvin T. Jetton S. Lidofsky K. Wahlberg M. Wood M. Takla B. Everett M. LaMantia A. Repp

Committee Mission: The Grand Rounds Committee reviews the format for Grand Rounds and its speakers to insure that it is scientifically sound, presenting up-to-date information, and assisting the medical residents and medical students in becoming familiar with the research going in within the Department. We also review candidates nominated for the Tisdale Lectureship.

Scientific Integrity Committee – updated R. Budd, Chair C. Irvin

Committee Mission: Scientific Integrity Committee advises the Chair on issues related to policies for reviewing possible scientific fraud.

Medicine Operations Committee

F. Keating, Chair J. Kelly N. Bethina S. Patil S. Grant D. Haddock T. Holmes J. Powelson L. Smith A. Kumar R. Zubarik R. Clouser A. Mead

Committee Mission: The Department of Medicine Operations Committee serves to improve operational efficiency and cross-divisional collaboration. To that end, the committee reviews operational data and compares practices across the Divisions, and advises the Departmental leadership (Chair and Unit Chiefs) regarding operational matters.

Department of Medicine Faculty Development Committee- updated

The Faculty Development is composed of 1-2 faculty from each division in the Department of Medicine and meets monthly. The charge of the committee is to work with the Chair, Department of Medicine on matters related to faculty development, including faculty mentoring, career development, and promotion. The committee serves as a forum for junior and mid-level faculty to discuss faculty development within the DOM and to foster new initiatives to support the DOM faculty. Current efforts include the development and dissemination of:

 Faculty mentoring and career development support tools  Promotion dossier (Green Sheet) guidance and a standardized Larner College of Medicine CV format  Metrics and guidelines for career development and promotion within the Clinical Scholar Path- way  Mechanisms to recognize and address faculty burnout  The Quarterly Faculty Development newsletter for the DOM

The current membership of the committee is listed below. Please contact Joseph Pierson or your divisional representative with questions.

Member Division/Position

Joseph Pierson, MD Chair

Lisa Pitrowiski Administration

Zail Berry, MD Geriatric Medicine

Maura Barry, MD Hematology/Oncology

Narandra Bethina, MD Rheumatology

Jason Botten, PhD Immunobiology

Garth Garrison, MD Pulmonary & Critical Care Medicine

Nicholas Ferrentino, MD Gastroenterology

Juan Perdomo Rodriguez Endocrinology

Farrah Khan, MD Hematology/Oncology

Rony Lahoud, MD Cardiology

Jason Bartsch, MD Hospitalist Medicine LeeAnna Burgess, MD

John Miller, MD Primary Care Medicine

Kristen Pierce, MD Infectious Disease

Marios Prikis, MD Nephrology

Christine Weinberger, MD Dermatology

Department of Medicine Reappointment, Promotions, and Tenure Committee

The Reappointment, Promotions, and Tenure Committee is composed of 3 subcommittees: The Tenure Pathway and Promotions Subcommittee, The Clinical Scholar Evaluation and Reappoint- ment Subcommittee, and The Volunteer Pathway Reappointment Subcommittee. Each are composed of selected faculty from the divisions of the Department of Medicine. All three subcommittees participate in the Spring RPT cycle which addresses faculty reappointments, while the Tenure Pathway subcommittee also meets for the Fall RPT cycle as well to evaluate faculty going up for promotion.

The current membership of the committee is listed below. Please contact Ben Suratt with questions.

Tenure Pathway and Promotions Subcommittee

Member Division/Position

Jason Bates, PhD Chair

Harold Dauerman, MD Cardiology

Christopher Huston, MD Infectious Disease

Benjamin Littenberg, MD GIM

Caroline Lyon, MD Hospitalist Medicine

Charles Maclean, MD GIM

Joseph Pierson, MD Dermatology

Renee Stapleton, MD, PhD Pulmonary & Critical Care Medicine

Committee Mission:

The mission of the Department of Medicine Tenure Pathway and Promotions Subcommittee is to provide support to the RPT Chair in the preparation of summary information required for reappointment and promotion of Department of Medicine faculty members on the Tenure Track Path- way, and for promotion dossiers of faculty on all promotion tracks. The Committee is charged with reviewing the content of dossiers, assembled by each faculty member under consideration and corresponding unit director, and with writing summaries that highlight accomplishments in the areas of teaching, research and scholarship, and service to the institution and beyond. Each summary will also serve to generate constructive feedback to the faculty member under consideration, so that the goals for future promotion can be achieved. The Subcommittee will meet at least once during the faculty review cycle to finalize the summaries, which will then be forwarded by the Subcommittee Chair to the RPT Committee Chair.

Clinical Scholar Evaluation and Reappointment Subcommittee

Member Division/Position

Kristen Pierce, MD Chair

Tanya Bertsch, MD GIM

Shaden Eldakhar-Hein, MD Hospitalist Medicine

Matthew Gilbert, DO Endocrinology

Peter Kaufman, MD Hematology/Oncology

Chi-Chi Lau, MD Rheumatology

Doris Strader, MD Gastroenterology

Peter Van Buren, MD Cardiology

Timothy Whitman, DO Infectious Disease

Volunteer Pathway Reappointment Subcommittee

Member Division/Position

Claudia Berger, MD Chair

Roberta O'Brien, MD GIM

Garth Garrison, MD Pulmonary & Critical Care Medicine

Committee Mission:

The mission of the Department of Medicine Volunteer Pathway Reappointment Subcommittee is to provide support to the RPT Chair in the preparation of summary information required for reappointment of Department of Medicine faculty members on the Volunteer Pathway. The Commit- tee is charged with reviewing the content of dossiers, assembled by each faculty member under consideration and corresponding unit director, and evaluating eligibility of the faculty member for reappointment on the Volunteer Pathway. The Subcommittee will meet at least once during the faculty review cycle to finalize the recommendations, which will then be forwarded by the Subcommittee Chair to the RPT Committee Chair.

Research Committee

R. Budd, MD M. Poynter, PhD M. Toth, PhD J. Gupta, PhD A. Atherly, MD M. Cushman, MD M. Bui, MD PhD S. Lidofsky, MD PhD R. Solomon, MD A. Repp, MD C. Lyon, MD T. Mazuzan – Staff M. Rowen – Staff

Committee Mission: The Department of Medicine’s Research Committee is Chaired by the Vice Chair for Research with faculty representation from each Division/Center and financial/operations leadership staff. The committee meets monthly to discuss a wide range of issues pertaining to the research mission and activities of the department’s faculty. A major focus of the committee is to advise the Chair on decisions that impact the research endeavors of the department’s faculty. Other topics include the development and review policies and procedures relating to research, funding requests, new funding opportunities, changes in Federal policies, dissemination of information and setting new initiatives to enhance the research activities of the department.

Quality Assurance Committee – Dermatology – upated T. Holmes, MD G. Goldman, MD C. Weinberger, MD M. Bui, MD A. Fischer, MD K. Morley, MD

Committee Mission: Our mission is to ensure quality care and promote continuous quality improvement of services and processes in order to fulfill the needs and expectations of the patients we serve.

Medical Service Ambulatory Care Visits: 212,084 (151,373 specialty care and 60,711 primary care) Work RVUs: 565,278 work RVUs

UVMMC Practice Sites: Ambulatory Care Center – Medicine has a presence in five Modules:  Medicine: Infectious Disease (including Travel Medicine), Rheumatology and Clinical Immunol- ogy, and Pulmonary (including PFTs), Lung Cancer Multidisciplinary Clinic

 Dermatology including Mohs Surgery (occupying two modules)

 Cancer Center: Hematology/Oncology, Breast Care Center and Multidisciplinary Clinic, Vermont Regional Hemophilia Treatment Center, Thrombosis Center, and

 Surgery: Gastroenterology

University Health Center  Nephrology

 Sleep Medicine

Tilley Drive, South Burlington  Cardiology and Cardiac Rehabilitation, Oncology Rehabilitation, Pulmonary Rehabilitation

 Endocrinology, Osteoporosis, and Endocrine Clinical Research

Fanny Allen Hospital  Memory Clinic

 Vermont Lung Center (Pulmonary Research)

General Internal Medicine:  Burlington (University Health Center

 South Burlington

 Essex Junction

 Williston

UVMMC Outreach Sites: Vermont Brattleboro (BMH) – Infectious Disease St. Albans (Northwestern Medical Center) –Nephrology, Cardiology, and Endocrinology St. Johnsbury (Northeastern Medical Center) - Infectious Disease Barre (Central Vermont) – Nephrology, Dermatology, Pulmonary, Hem/Onc Rutland (Rutland Regional) – Nephrology, Cardiology, Infectious Disease Middlebury (Porter) – Cardiology, Hem/Onc Newport (Newport Memorial) – Nephrology New York Malone (AHMC) - Cardiology Massena (MMH) – Cardiology Plattsburgh (CVPH) – Cardiology, Infectious Disease, Dermatology Nursing Homes and Other Locations:

Elderwood Nursing Facility The Arbors at Shelburne Birchwood Terrace Nursing Facility Green Mountain Nursing Facility Visiting Nursing Association of Vermont

The Department also participates in many multidisciplinary clinics: Department of Medicine Multidisciplinary Clinics and Case Conferences/Tumor Boards (examples of participants in parentheses) Active • Maternal Fetal Medicine/Gestational Diabetes (Endocrine, Women’s)

• Upper GI MDC and Tumor Board(Gastroenterology, Hematology/Oncology, Rad. On-cology, Pathology, Radiology, Surgery)

• Lung MDC and Tumor Board (Pulmonary, Surgery, Radiation Oncology, Hematol-ogy/Oncology, Pathology, Radiology)

• Breast MDC and Tumor Board (Hematology/Oncology, Radiology, Surgery, Radiation Oncology, Pathology)

• Hem Malignancy Conference (Hematology/Oncology, Pathology)

• Brain Tumor Board (Hematology/Oncology, Surgery, Radiology, Radiation Oncology)

• Sarcoma Tumor Board (Hematology/Oncology, Orthopedics, Radiology, Pathology, Ra-diation Oncology)

• ENT Tumor Board (Hematology/Oncology, Surgery, Radiation Oncology)

• GU MDC and Tumor Board (Hematology/Oncology, Surgery, Pathology)

• Melanoma Tumor Board (Dermatology, Surgery, Hematology/Oncology, Pathology)

• Familial Cancer Program Conference (Genetic counseling, medical oncology, pathology, surgical oncology, ob/gyn).

• Geriatrics/Memory Center (Geriatrics and Neurology)

• Interstitial Lung Disease (Pulmonary and Rheumatology

• Cystic Fibrosis (Pulmonary, Endocrinology, Social Work, Nutritional Services)

• Bone Metabolism (Endocrinology and Rheumatology)

• Stone Clinic (Nephrology and Urology)

• Transplant Clinic (Nephrology and Transplant Surgery)

18 • Oncology Rehabilitation (Hematology/Oncology, Cardiology, Physical Therapy)

• Pulmonary Rehabilitation (Pulmonary, Cardiology, and Physical Therapy)

• Heart Failure (Cardiology and Primary Care)

• TAVR (Cardiology and Surgery)

• Accredited Stem Cell Transplant Program (Hematology and Pathology/Laboratory)

• Pediatric Hemophelia Clinic (Hematology/Oncology and Pediatrics)

• Weight management clinic (Endocrinology and Bariatric Surgery)

• Teledermatology (Colchester Family Medicine and Dermatology)

• Telemedicine (Infectious Disease and Brattleboro Memorial Hospital)

Under Development • Hepatitis C e-consults (Gastroenterology and General Internal Medicine)

19 Graduate Medical Education Annual Report: 2019-2020

1. Leadership

Mark Pasanen, M.D., FACP – Program Director Shaden Eldakar-Hein, M.S., M.D., FACP – Associate Program Director Halle Sobel, M.D., FACP – Associate Program Director Kate Parker, Christine Farnham and Rosanne Murat – Program Administrators

2. Summary of Program Highlights 2019-2020

Enhancements to Curriculum: We continue to refine our didactic education, having switched to an academic half-day model in 2015. Residents are split into two cohorts (first-year residents and senior residents), allowing our curriculum to be targeted at the learner level. In addition, as part of this change, we encouraged our faculty to develop more interactive teaching methods – which continues to be well-received by both faculty and residents. The switch to an academic half-day model allowed for a more comprehensive curriculum, including robust Improvement Science and Wellness initiatives. We are now in the process of updating our Resident-As-Teacher curriculum, to assure an optimal learning environment for all learners. In addition, over the past 18 months, we have successfully moved Morning Report to Noon Report to allow for increased attendance, and better engagement. Of course, the biggest change of the past year has been the need to adapt to on-line learning due to gathering restrictions in place to protect our residents, patients and others from COVID-19. After a brief period, we were able to successfully transition all of structured teaching to an interactive, tele-education environment.

Board Preparation: Our comprehensive curriculum supports our residents as they prepare for the ABIM certification exam. Our 3-year pass rate remains at 95%, which is above the national average. We continue to provide MKSAP for all of our residents, and utilize MKSAP questions in many of our teaching sessions. In addition, we provide all residents with sub- scriptions to NEJM Knowledge (+), a mobile question-based board review product with an adaptive learning interface as part of our commitment to ABIM Board success.

Continuity Clinic Update: With the leadership of Drs. Halle Sobel and Rich Pinckney – along with a core of faculty preceptors, small group learning sessions are extremely well received by residents – all part of a comprehensive 3-year curriculum. Residents are educated on practice management, patient safety and quality improvement and continue to complete personal practice improvement projects. At the core of the experience is providing care for a diverse population of primary care patients. Residents are assigned to either the UVMMC Adult Primary Care site in Burlington or the Burlington VA clinic (under the leadership of Drs. Jonathan Cohen and Gretchen Gaida-Michaels). In addition, we have incorporated the Yale Ambulatory Curriculum, which focuses on common primary care issues, into the formal educational experience.

Wellness: Our Resident Wellness Committee has the the goal of promoting resiliency by creating opportunities for our residents to engage in activities with each other and our community. Events in the past have included attending a Lake Monsters game, picking apples and making cider, paddle-boarding, paint-and-sip, along with dinners at the Hope Lodge (cooked and served by our residents). This has been a huge challenge for the latter part of the year, given the need to remain socially-distanced, so the committee continues to look for unique opportunities to promote wellness.

Improvements in Evaluation/Assessment: With leadership from Dr. Sobel, our robust Clinical Competency Committee reviews all of our residents at least bi- annually, providing milestone-based evaluations and feedback. In addition, this group provides insight and guidance

20 for residents who benefit from more structured support. Over the past year, we have refined our evaluations, with the goal of getting the most important information in the most efficient way possible.

Recruitment: With leadership from Dr. Eldakar-Hein, we had another fabulous resident recruitment cycle. Given the significant increase in the number of programs each student applies to, recruitment is a major undertaking. Therefore, we have increased the number of resident candidates we interview, with numerous faculty volunteering their time. The outcome of all this effort was another incredibly successful recruitment season.

Procedural/Ultrasound Training: One of our priorities over the past few years has been to improve our resident procedural and ultrasound skills. We have improved our ultrasound elective, and have recently added a digital repository for collected images, significantly increasing our capacity to review images and provide feedback. In addition, we continue to collaborate with colleagues in the Department of Medicine and other departments with the goal of getting our residents opportunities to perform desired procedures.

3. List of All Residents (as of July 1, 2019 – Graduating Residents and Match Results below) PGY-3 Calvin Gilkey University College Cork, Ireland Edwin Goncharuk University of New England College of Osteopathic Medicine Benjamin Irvine University of Wisconsin School of Medicine and Public Health Darren Knox University of Wisconsin School of Medicine and Public Health Daniel Krakauer Virginia Tech Carillion School of Medicine Yao Li Albany Medical College Steven O’Neill West Virginia University School of Medicine Katherine Peterson University of New England College of Osteopathic Medicine Louis-Bassett Porter Pennsylvania State University School of Medicine Elly Riser University of Washington School of Medicine Brendan Thoms Imperial College of Medicine, United Kingdom Shawn Wayne University of Wisconsin School of Medicine and Public Health Andrew Wilks Tufts University School of Medicine Christopher Wargo University of Queensland, Australia Scott Young University of Washington School of Medicine

PGY-2 Categorical Eric Anderson Medical College of Wisconsin Jennifer Bergeron Tufts University School of Medicine Kenyon “KC” Bolton Robert Larner, MD, College of Medicine at the University of Vermont Benjamin Depo State University of New York Upstate Matthew Gervais Pennsylvania State University College of Medicine J. Curtis Gwilliam Robert Larner, MD, College of Medicine at the University of Vermont Sundas Khan Lewis Katz School of Medicine at Temple University Carrie Mahurin University of North Dakota School of Medicine and Health Sciences Emily McPherson University of New England School of Osteopathic Medicine Jacob Neuwirth University of New England College of Osteopathic Medicine Jacqueline Parker Weill Cornell Medicine Kevin Qin University of Toledo College of Medicine and Life Sciences Samantha Steinmetz-Wood Royal College of Surgeons in Ireland Andrew Wall Albany Medical College Joshua Zimmer Quillen College of Medicine at East Tennessee State University

Chief Medical Residents Elizabeth Wahlberg University of Washington School of Medicine Kramer Wahlberg University of Washington School of Medicine Julia Powelson University of Alabama School of Medicine

4. Resident and Faculty Awards

 The Harriet P. Dustan, M.D. Award Elly Riser, M.D.

 The Frank L. Babbott, M.D. Memorial Award Elly Riser, M.D.

 Richard E. Bouchard, M.D. Excellence in Primary Care Award Daniel Krakauer, MD

 Richard E. Bouchard, M.D. Excellence in Primary Care Award Brendan Thoms, MD

 E.L. Amidon, M.D. Award Outstanding Teacher of the Year Subspecialty Medicine William Hopkins, M.D.

 Mark A. Levine, M.D. Award Outstanding Teacher of the Year General Internal Medicine Lee-Anna Burgess, M.D.

5. Resident presentations at local/regional/national meetings and publications

Resident Research Day: May 22, 2020

Oral Presentations: Andrew Wilks, MD, MS Bleeding risk in a cohort of ambulatory cancer patients receiving prophylactic anticoagulation for venous thrombosis prevention Andrew Wilks MD, MS, Daniel Douce MD, Steven Ades MD, MSc, Mary Cushman MD, MSc, Neil Zakai MD, MSc, Chris Holmes MD, PhD

Louis-Bassett Porter, MD Improving utilization of antimicrobials and anticoagulants in patients hospitalized for a malignant hematologic condition with use of a checklist Louis-Bassett Porter, MD, Hanaa Shihadeh, BS, Bradley Tompkins, MPH, MS, Kim Dittus, MD, PhD

Elly Riser, MD, MPH Training Future Physicians to Provide Evidence-Based Care for Individuals with Opioid Use Disorder: The Addiction Medicine Curriculum at the Larner College of Medicine Elly Riser, MD, MPH, Sanchit Maruti, MD, John Brooklyn, MD, Stephen G. DeVoe, MPH, MS,

Leigh Ann Holterman, PhD, Jacqueline Drouin, MPA, Halle Sobel, MD

Poster Presentations: Calvin Gilkey, MD When Can I Leave? A Retrospective Cohort Study Exploring if Day and Time of Admission are Associated with Length of Stay or Mortality in Hospitalized Adults Calvin Gilkey, MD, Bradley Tompkins, MPH, MS, Allen Repp, MD, MSc

Edwin Goncharuk, DO Biochemical Liver Testing Among Diabetics in Primary Care: Incidence and Influence on Screening for Advanced Hepatic Fibrosis Brendan Everett, MD, Edwin Goncharuk, DO, Maia Stamieszkin, APRN, Steven Lidofsky, MD, PhD

Ben Irvine, MD Bachmann’s Bundle Pacing on the Burden, Recurrence, and Incidence of Atrial Arrhythmias Margaret Infeld MD, MS, Charles D. Nicoli BS, Sean Meagher BS, Shawn Wayne MD, Bradley Tompkins MPH, MS, Benjamin Irvine MD, Omkar Betageri MD, Nicole Habel MD, Markus Meyer MD, Daniel L. Lustgarten MD, PhD

Darren Knox, MD Factors leading to appropriate follow-up of lung nodules discovered incidentally on CT chest during hospitalization; a single-site study Darren Knox, MD, Arjun Patel, MS, BS Bradley Tompkins, MPH, MS, Shaden Eldakar-Hein, MD, MS

Dan Krakauer, MD Guideline Adherence for Patients Hospitalized with Neutropenic Fever at the University of Vermont Medical Cen- ter: An Observational Study Daniel Krakauer, MD, Kaileen Cruden, BS, Allen Repp, MD, MSc

Jim Li, MD Appropriateness of prescriptions for factor Xa inhibitors apixaban and rivaroxaban at discharge: A retrospective cohort study Jim Yao Li, MD, Bradley Tompkins, MPH, MS, Allen Repp, MD, MSc

Steve O’Neill, MD The Effect of Patient Educational Attainment on Cardiac Rehabilitation Adherence and Benefits of Cardiac Rehabili- tation Steven O’Neill, MD, Diann E. Gaalema, PhD, Patrick Savage, MS, Hypatia A. Bol, PhD, Deborah Denkmann, BSN, Philip A. Ades, MD

Katherine Peterson, DO The Impact of a Best Practice Advisory on Inpatient Use of Piperacillin-Tazobactam Katherine L. Peterson, DO Bradley J. Tompkins, MPH, MS, John W. Ahern, PharmD, Lindsay M. Smith, MD

Brendan Thoms, MBBS, PhD Use of an Educational Leaflet and Patient-directed Exercises in the Management of Chronic Lower Back Pain Brendan Thoms, MBBS, PhD and ChiChi Lau, MD

Brendan Thoms, MBBS, PhD “Do they need a hospital bed?” - A 6-month audit of patients managed under observation status by the internal medicine teaching service

Brendan L. Thoms, MBBS PhD and Steve Grant, MD

Christopher Wargo, MBBS, PhD Assessment of Patient Factors Impacting Internal Medicine Service 30 Day Readmission Rates at the UVM Medical Center Christopher Wargo, MBBS, PhD and Mark Pasanen, MD

Shawn Wayne, MD The Effect of Multiple Radiofrequency Ablation for Atrial Fibrillation on Left Atrial Pressure and Compliance Margaret Infeld, MD, MS, Charles Nicoli, BS, Shawn Wayne, MD, Sherrie Khadanga, MD, Timothy Plante, MD, MHS, Bradley Tompkins MPH, MS, Daniel Correa de Sa, MD, Peter VanBuren, MD

Scott Young, MD Right Ventricle Dysfunction & Exercise Tolerance In Pulmonary Rehabilitation - A Retrospective Study Scott K. Young, MD, Bradley Tompkins, MPH, MS, Charlotte C. Teneback, MD

Vermont ACP Scientific Meeting October 2019

Presenter Title Category Elly Riser, MD A Fatal Case of Pembrolizumab-Induced Myasthenia Gravis Clinical Vignette Sundas Khan and Ben- A Pathway for Optimizing Post-Splenectomy Care Research jamin Depo Edwin Goncharuk When the PPI Doesn’t work Clinical Vignette Aurasch Moaven A Case of Reactive Arthritis Secondary to Intravesicular BCG Clinical Vignette Therapy Dash Porter Retrospective Review of Appropriate Use of Antimicrobials Research and Anticoagulants in Patients Hospitalized for a Malignant Hematologic Condition

Publications: van Eeghen, C, Kennedy AG, Pasanen ME, MacLean CD. A new Quality Improvement Toolkit to Improve Opioid Pre- scribing in Primary Care. J Am Board of Fam Med. 2020 Jan-Feb;33(1),17-26.

Sobel HG, Goedde M, Maruiti S, Hadley-Strout E, Wahlberg E, Kennedy AG. Primary Care Residents Delivering Care: Integration of Office-Based Opioid Treatment into an Internal Medicine Residency Curriculum. Acad Psychia- try. 2019 Oct;43(5):499-502.

Sheahan KH, Wahlberg EA, Gilbert MP. An overview of GLP-1 agonists and recent cardiovascular outcomes trials. Postgrad Med J. 2020 Mar;96(1133):156-16.

Wahlberg K, Arnold ME, Lustgarten D, Meyer M. Effects of Higher Heart Rate on Quality of Life and Functional Ca- pacity in Patients with Lever Ventricular Diastolic Dysfunction. Am J Cardiol. 2019 Ocg 1;124(7):1069-1075.

Bullis SSM, Crother JW, Wayne S, Hale AJ. A Cautionary Tale of False-Negative Nasopharyngeal COVID-19 Testing. ID Cases. 2020 May 5.

Gill, T.J., Wall, A.J., Gwathmey, F.W., Whalen, J., Makani, A., Zarins, B., Berger, D. Surgical Release of the Ad- ductor Longus With or Without Sports Hernia Repair Is a Useful Treatment for Recalcitrant Groin Strains in the Elite Athlete. Orthop J Sports Med. 2020 Jan 27;8(1):2325967119896104. doi: 10.1177/2325967119896104. PMID: 32047829; PMCID: PMC6985970.

Wall, A.J., McGonigle, O., & Gill, T.J. Arthroscopic Circumferential Labral Repair for Patients With Multidirectional Instability: A Comparative Outcome Study. Orthop J Sports Med. 2019 Dec 27;7(12):2325967119890103. doi: 10.1177/2325967119890103. PMID: 31909054; PMCID: PMC6935876.

National/Regional Presentations:

Wall, A.J., Lentz, S., Dayman, C., Clouser, R., Atherly, A., Stapleton, R. (May, 2020). Factors Associated with Clinical Outcomes Among Critically Ill Patients Transferred from Small Rural Hospitals to a Tertiary Medical ICU. Scheduled to be presented at: The American Thoracic Society Annual Meeting; Philadelphia, PN, USA. Conference cancelled due to COVID-19.

Sundas Khan, MD and Ben Depo, MD A Pathway for Optimizing Post-Splenectomy Care  Poster presentation at the 2019 Vermont ACP Chapter Meeting, October 11, 2019, Stowe, VT  Poster presentation at the National American College of Chest Physicians Meeting, Los Angeles, CA, April 2020

Potential Germline Findings Identified During Somatic Tumor Testing: Room for Improvement Khan S, Wright H, Cuke M, Folefac E, Verschraegen C, Wood, M  Poster presentation at American Society of Clinical Oncology, Chicago, IL, May 2020

Elly Riser, MD A Fatal Case of Pembrolizumab-Induced Myasthenia Gravis  Poster Presentation at the 2019 Vermont ACP Chapter Meeting, October 11, 2019, Stowe, VT  Poster Presentation – 2020 ACP National Conference, April 24, 2020 (Posted presented virtually due to COID-19 pandemic) The relationship between psychostimulant use and cardiovascular disease  Oral presentation at the American Academy of Forensic Sciences 72nd Annual Scientific Meeting, February, 17, 2020, Anaheim, CA

Aurasch Moaven, MD A Case of Reactive Arthritis Secondary to Intravesicular BCG Therapy  Poster Presentation at the 2019 Vermont ACP Chapter Meeting, October 11, 2019, Stowe, VT

Zimmer, J. Morbidity and Mortality Review. Case presentation at Medicine Grand Rounds at the University of Ver- mont Medical Center. Jan 17th, 2020.

Irvine B. Morbidity and Mortality Review. Case presentation at Medicine Grand Rounds at the University of Ver- mont Medical Center. Feb 24th, 2020.

Bolton, KC. Morbidity and Mortality Review. Case presentation at Medicine Grand Rounds at the University of Ver- mont Medical Center. Dec 13th, 2019.

Porter, LB. Morbidity and Mortality Review. Case presentation at Medicine Grand Rounds at the University of Ver- mont Medical Center. Nov 22nd, 2019.

Qin, K. Morbidity and Mortality Review. Case presentation at Medicine Grand Rounds at the University of Vermont Medical Center. Oct 25th, 2019.

Wilks, A. Morbidity and Mortality Review. Case presentation at Medicine Grand Rounds at the University of Ver- mont Medical Center. Sept 6th, 2019.

Deparment of Medicine Quality Showcase May 8, 2020:

Elizabeth A. Wahlberg, MD, Emily K. Hadley Strout, MD, Amanda G. Kennedy, PharmD, BCPS, and Halle G. Sobel, MD Making Population Health More Popular: Improving Preventive Health Through a Novel Personalized Panel Management Curriculum.

Steinmetz-Wood S, Anderson E, Wall A, Zimmer J, Bergeron J, Bolton KC, Depo B, Neuwirth J, Desautels A, Leahy K, Purcell K,Burnett M, Muthukrishnan P, Van Eeghen C, Kennedy AG Transitions of Care at Hospital Discharge - To call or not to call?

Benjamin Depo, MD*, Sundas Khan, MD*, Jean Dejace, MD, Laura Catoe, NP, Timothy Whitman, DO, Bradley Tompkins, MPH, MS, Carlos Marroquin, MD, Jennifer Gratton, RN, Ajai Malhrota, MD, Andrew Hale, MD * co-first authors. A Pathway for Optimizing Post-Splenectomy Care.

Depo B, Gervais M, Gwilliam C, Khan S, McPherson E, Mahurin C, Parker J, Qin K, Burnett M, Muthukrishnan P, van Eeghen C, Kennedy AG, Desautels A, Leahy K, Purcell K. Standardizing "Clinical Issues Needing Follow-up" to Improve Discharge Communication

Gilkey CT, Goncharuk E, Irvine BJ, Knox D, Krakauer DJ, Li Y, O’Neill SC, Peterson KL, Porter LB, Riser EA, Thoms BL, Wargo CJ, Wayne SP, Wilks AB, Burgess LK, Hood V, Stinnett-Donnelly J, Kennedy AG, Repp AB. Transitions "Should I Stay or Should I Go?" - A High Value Care Case Analysis.

Kramer Wahlberg, MD, Maria Burnett, MD, Andrea Desautels,* Kathy Leahy,* Preetika Muthukrishnan, MD, Kate Purcell,* Allen B. Repp, MD, MSc,. Partnering with Patients in a Quality Improvement Curriculum for Internal Medi- cine Residents. Constance van Eeghen, DrPH, MHSA, MBA, Elizabeth Wahlberg, MD, Amanda G. Kennedy, PharmD, BCPS.

KC Bolton, MD, Stephen G. DeVoe, MPH, MS, Jennifer Hauptman, MSW, LICSW, Amanda G. Kennedy, PharmD, BCPS, Marissa Madden, RN, Naomi Hodde, MD Gauging oncology inpatient experience before and during Covid-19 visitor restrictions: Implementation and preliminary results of a pre-discharge questionnaire.

KC Bolton, MD and Kramer Wahlberg, MD Improving the resident experience: Development of a SharePoint intra- net site to streamline administration and learning in an internal medicine program.

6. Graduating Residents – where are they going/ which fellowships Calvin Gilkey Hospitalist, Central Vermont Medical Center Edwin Goncharuk Chief Medical Resident, University of Vermont Medical Center Benjamin Irvine Chief Medical Resident, University of Vermont Medical Center Darren Knox Hospitalist, Gundersen Health System Daniel Krakauer Palliative Care Fellow, Ohio State University Medical Center Yao Li Hospitalist, University of Vermont Medical Center Steven O’Neill Hospitalist, Good Samaritan Regional Medical Center Katherine Peterson Fellowship, Infectious Disease, University of Vermont Medical Center Louis-Bassett Porter Hospitalist, Central Vermont Medical Center Elly Riser Hospitalist, University of Vermont Medical Center Brendan Thoms Fellowship, Rheumatology, University of Vermont Medical Center Shawn Wayne Chief Medical Resident, University of Vermont Medical Center Andrew Wilks Fellowship, Hematology/Oncology, University of Massachussetts Christopher Wargo Primary Care, University of Vermont Medical Center/Essex Scott Young Hospitalist, University of Washington Medical Center

Chief Medical Residents

Elizabeth Wahlberg Primary Care, University of Vermont Medical Center/South Burlington Kramer Wahlberg Fellowship, Cardiology, University of Vermont Medical Center Julia Powelson Hospitalist, University of Vermont Medical Center

7. MATCH RESULTS - Spring 2020

PGY-1 Categorical Siddique Akram University of Wisconsin School of Medicine and Public Health Vishwanath Anekonda University of Washington School of Medicine Tanesha Beebe Loyola University Chicago Stritch School of Medicine Maria Bryan - PC University of Minnesota Medical School Brendan Campbell George Washington University School of Medicine and Health Sciences Kyle Crooker University of Kansas School of Medicine – Wichita Brendan Ferraro Lewis Katz School of Medicine at Temple University David Jackson University of New England College of Osteopathic Medicine Ali Jandal University of Wisconsin School of Medicine and Public Health Colton Jensen University of Iowa Roy J. and Lucille A. Carver College of Medicine John Lamb Mercer University School of Medicine – Savannah Eleanor Stedman - PC Robert Larner, M.D., College of Medicine at the University of Vermont Nicholas Tooley Michigan State University College of Human Medicine - Grand Rapids Sarah Wachtel - PC Albany Medical College Danielle Wall Robert Larner, M.D., College of Medicine at the University of Vermont

Preliminary Hannah Porter University of Pittsburgh School of Medicine Daniel De Los Santos Robert Larner, M.D., College of Medicine at the University of Vermont Gregory Johnston Robert Larner, M.D., College of Medicine at the University of Vermont Agnes Bacopulos (Neurology) New York Medical College Kristin Bartman (Neurology) Central Michigan University COM Kaley Kinnamon (Neurology) University of Kansas School of Medicine Lauren Skogsholm (Neurology) University of Connecticut School of Medicine

Preliminary Anesthesia shared with Surgery Jack Chan Albany Medical College Jason Dixon University of Connecticut School of Medicine Edwin “Taylor” Haring University of Oklahoma College of Medicine Brett Heber Kansas City Univ of Medicine & Biosciences College of Osteopathic Medicine Britta Kilgus Robert Larner, M.D., College of Medicine at the University of Vermont Matthew “Matt” Nowland Frank H. Netter, M.D. School of Medicine at Quinnipiac University

Cardiovascular Division David J. Schneider, MD, Director https://www.uvmhealth.org/medcenter/Pages/Departments-and-Programs/Cardiology.aspx

The 2019-2020 academic year will be a year that changed the professional and personal lives of everyone because of the COVID-19 pandemic. The cardiovascular division pulled together and developed protocols enabling continued care of patients during a time of active transmission of COVID-19 in Vermont. As infection transmission slowed in Vermont, the division served the needs of our patients by rapidly expanding clinical activities. While we have learned the value of telehealth, our experience has emphasized that much of cardiovascular care requires direct patient contact. The Division experienced transitions during this academic year. Drs. Mark Capeless and John Fitzgerald retired. Mark has left an indelible mark on the cardiovascular division. He developed our electrophysiology section and was the Director of our fellowship training program for many years. John transitioned from private practice to be the primary cardiologist serving North- western Medical Center in St. Albans. Drs. Markus Meyer and Johannes Steiner left the University of Vermont for new opportunities. Markus was recruited to an endowed Chair at the University of Minnesota that will enable him to concentrate his efforts on research advances. Johannes will lead the mechanical support team in Oregon. We miss each of them but wish them the best in their next steps. Transitions create opportunities for the infusion of new individuals who will expand our capabilities. During the summer of 2020 we will add 2 new cardiologists focused on heart failure care. Dr. Trace Barrett has joined our division. In addition to expanding our heart failure team, Trace has a particular interest in invasive echocardiography to support structural heart procedures. Trace completed his training at the University of Vermont. Dr. Ahmed Harhash will also join our heart failure team. Ahmed completed training in advanced heart failure at Mid America Heart Institute. Dr. Tracy Hagerty joins our division and will be the primary cardiologist at Northwestern Medical Center. Tracy completed cardiovascular training at Washington University. Education of the next generation of leaders in cardiovascular care is a core mission of the cardiovascular division. We graduated an outstanding class of fellows (Drs. Infeld, Nambiar, Sil- verman, and Barrett). This group authored 6 PubMed-indexed publications in 2019 and 2020 alone with several manuscripts still in preparation. Lakshmi Nambiar was recognized by the American College of Cardiology and her presentation garnered media attention in advance of the national scientific sessions. We are pleased that all 4 graduating fellows will continue on in academic settings, 3 in subspecialty fellowships in Vermont, South Carolina and New York in addition to Dr. Barrett joining the Vermont faculty. We are proud of the diversity of our training program. While female representation in US cardiovascular fellowship programs hovers just below 20%, the percentage of women-identified fellows in our program was 33%. Our fellowship Jeopardy team won the Northern New England Chapter of the American College of Cardiology Jeopardy Competition. Scholarly activities complete the tripartite mission of the division. Clinical and translational research remain active with both investigator-initiated research as well as participation in multicenter clinical trials. The faculty of the cardiovascular division authored 46 scholarly publications during the past fiscal year.

Faculty

David J. Schneider, MD Professor of Medicine Director, Cardiovascular Division Medical Director, Cardiovascular Services, University of Vermont Health Network Research and clinical interests . thrombosis . platelet biology . atherosclerosis/ischemic heart disease . preventive cardiology

Aderonke Adeniyi, MD Assistant Professor of Medicine Research and clinical interests . advanced heart failure . pulmonary hypertension

Philip A. Ades, MD Philip A Ades MD Endowed Professor of Cardiovascular Prevention Director, Cardiac Rehabilitation Research and clinical interests . cardiac rehabilitation . preventive cardiology . ischemic heart disease

Mark Capeless, MD (retired, emeritus) Professor of Medicine Research and clinical interests . clinical cardiac electrophysiology

Kevin Carey, MD Assistant Professor of Medicine Research and clinical interests . coronary intervention . cardiac catheterization . ischemic heart disease

Daniel Correa de Sa, MD Assistant Professor of Medicine Research and clinical interests . clinical cardiac electrophysiology . catheter ablation . pacemaker and ICD implantation

Harold L. Dauerman, MD Professor of Medicine Network Director, Interventional Cardiology, UVM Health Network Research and clinical interests . coronary and structural heart intervention . vascular biology, PCI pharmacology . systems of care and regional quality improvement programs

Timothy Garrand, MD Interventional Cardiology Clinical interests . ischemic heart disease . cardiac catheterization . coronary intervention

Eric Gauthier, MD Assistant Professor of Medicine Clinical interests . ischemic heart disease . cardiac catheterization . coronary intervention

Prospero B. Gogo, MD Associate Professor of Medicine Director, Cardiovascular Catheterization Laboratory Director Interventional Cardiology Training Program Research and clinical interests . cardiac catheterization . percutaneous coronary intervention . percutaneous treatment of structural heart disease

William E. Hopkins, MD Attending Cardiologist Director, Adult Congenital Heart Disease Program Clinical interests . adult congenital heart disease . genetic heart disease . valvular heart disease . echocardiography

Roger Ishac, MD Assistant Professor of Medicine Clinical interests . ischemic heart disease . cardiac catheterization . coronary intervention

Tracy Hagerty, MD Assistant Professor of Medicine Clinical interests . general cardiology . syncope . pacemaker and defibrillator therapy

Friederike Keating, MD Professor of Medicine Director, Nuclear Cardiology and Stress Laboratory Program Director, Cardiovascular Fellowship Research and Clinical interests . multimodality imaging . medical education . cardiovascular disease in women . inpatient general cardiology

Robert J. Kelm, Jr., PhD Associate Professor of Medicine Associate Professor of Biochemistry Research interests . molecular biology of cell differentiation . mechanisms of cardiovascular remodeling . regulation of gene expression . protein-nucleic acid interactions

Sherrie Khadanga, MD Assistant Professor of Medicine Assistant Director, Cardiac Rehabilitation Research and clinical interests . cardiac rehabilitation . women and cardiovascular disease . systolic heart failure

Rony Lahoud, MD Assistant Professor of Medicine Research and clinical interests . cardiac catheterization . coronary intervention . structural heart disease . renal injury and recovery with coronary and structural procedures . optimal platelet therapy post coronary intervention

Martin M. LeWinter, MD Professor Emeritus of Medicine and Molecular Physiology and Biophysics

Research and clinical interests . heart failure and cardiomyopathies . cardiac hypertrophy . heart failure with preserved ejection fraction . effects of hypertension and diabetes on the myocardium . pericardial disease

Robert Lobel, MD Assistant Professor of Medicine Research and clinical interests . clinical cardiac electrophysiology . catheter ablation . pacemaker and ICD implantation

Daniel Lustgarten, MD Professor of Medicine Research and clinical interests . clinical cardiac electrophysiology . catheter ablation . pacemaker and ICD implantation . His bundle pacing

Richard L. Page, MD Professor of Medicine Dean, Robert Larner, M.D. College of Medicine Research and clinical interests . sudden cardiac death . automated external defibrillators . pharmacological therapy for atrial fibrillation

Peter S. Spector, MD Professor of Medicine Director, Cardiac Electrophysiology Director, Electrophysiology Fellowship Training Program Research and clinical interests . catheter ablation . atrial fibrillation

Jeffrey L. Spees, PhD Professor of Medicine Director, Stem Cell Core Facility Research interests . adult stem cell biology . regenerative medicine . repair of cardiac and CNS tissues . vascular biology

Edward Terrien, MD Associate Professor of Medicine Director, Ambulatory Cardiovascular Clinic Research and clinical interests . coronary intervention . cardiac catheterization . peripheral vascular intervention . ischemic heart disease

Nathaniel Thompson, MD Assistant Professor of Medicine Research and clinical interests . clinical cardiac electrophysiology . catheter ablation . pacemaker and ICD implantation

Marc D. Tischler, MD Associate Professor of Medicine Director, Echocardiography Laboratory Co-Director, Cardiac MRI Laboratory Research and clinical interests . magnetic resonance imaging and echocardiography . valvular heart disease . ischemic heart disease . congestive heart failure

Michael J. Toth, PhD Professor of Medicine Research interests . skeletal muscle physiology . cardiac rehabilitation . aging . physical disability . muscle disuse

Peter VanBuren, MD Associate Professor of Medicine Associate Professor of Molecular Physiology and Biophysics Director, Cardiovascular Care Unit Director, Heart Failure Program Associate Director Cardiovascular Training Program Research and clinical interests . specialist in heart failure . echocardiography . nuclear cardiology

Matthew W. Watkins, MD Professor of Medicine Director of Interventional Cardiology Research and clinical interests . interventional cardiology . ischemic heart disease

Joseph Winget, MD Associate Professor of Medicine Research and clinical interests . clinical cardiac electrophysiology . catheter ablation . pacemaker and ICD implantation

Magdalena Zeglin, MD Assistant Professor of Medicine Research and clinical interests . coronary artery disease . interventional cardiology

Pierre Znojkiewicz, MD Assistant Professor of Medicine Research and clinical interests . clinical cardiac electrophysiology . catheter ablation . pacemaker and ICD implantation

Fellows

Trace Barrett Cecile King David Cleary Matthew Kluge Jan Denkmann Drew Messerschmidt Christine DeStephan Lakshmi Nambiar Nicole Habel Newton Phuong Jonathan Halevy Brennan Rigby Bhisham Harchandani Ashwini Sharma Margaret Infeld Daniel Silverman

Nurse Practitioners and Physician Assistants

Cara DiMasi, APRN Margaret MacDonald, NP Gregory Ehle, PA Allison Mack, APRN Catherine Falduto, APRN Cheryl McNeil, APRN Susan Ann Hamlyn-Prescott, APRN Deborah Moyer, APRN

Ann Laramee, APRN Nancy Strong, APRN Graduate Students, Post-doctoral Fellows, MD PhD Students

Martin M. LeWinter, MD Lakshmi Nambiar Dan Silverman

Jeffrey L. Spees, PhD John McInnis, B.S. Nicholas Toker, B.S. Lucy Greetham, B.S.

Michael J. Toth, PhD Blas Guigni, CMB doctoral candidate Timothy W. Tourville, PhD, K08 mentee

Leadership in Professional Societies

Prospero B. Gogo, MD Vermont Chapter of the American College of Cardiology, Past Governor ABIM Item Writing Task Force for Interventional Cardiology ABIM Standards-setting for Interventional Cardiology

Friederike Keating, MD American College of Cardiology, Governor for VT and President of the Northern New England Chapter American College of Cardiology, Member, ACC Program Director and GME Steering Council American College of Cardiology, Member, Membership Committee American College of Cardiology, Organizer, Virtual Learning Panel ASNC, Member, Health Policy Council

Robert J. Kelm, Jr., PhD UVM Institutional Biosafety Committee, Chair Graduate Studies Committee, Department of Biochemistry, Chair Biochemistry Graduate Program, Director

Rony Lahoud, MD American College of Cardiology, Fellow Society of Cardiac Angiography and Intervention, Fellow, Member of Communications Steering Committee

Martin M. LeWinter, MD Council on Clinical Cardiology, American Heart Association, Fellow American College of Cardiology, Fellow Council on Circulation and Basic Cardiovascular Sciences, American Heart Association

Association of University Cardiologists, Fellow International Academy of Cardiovascular Sciences, Fellow

Daniel Lustgarten, MD Heart Rhythm Society, Fellow American College of Cardiology Political Action Committee, Member Paul Dudley White Society - Cardiology Division, Member

Richard L. Page, MD Heart Rhythm Society, Past President Association of Professors of Cardiology, Past President American Clinical and Climatological Association, Councilor

Matthew W. Watkins, MD Northern New England Cardiovascular Disease Study Group, Executive Board Green Mountain Care Board, Vt. State health care reform program, Advisory Board Green Mountain Care Board, Vt. State health care reform program for specialty practice, Tech- nical Advisory Board

Editorships and Editorial Boards

Philip A. Ades, MD Consulting Editor (former Editor-in-Chief): Journal of Cardiopulmonary Rehabilitation and Prevention Reviewer: Circulation, JACC, JAMA Cardiology, JACC Heart Failure, Journal of Cardiopulmo- nary Rehabilitation and Prevention

Harold L. Dauerman, MD Associate Editor, Journal of the American College of Cardiology

Prospero B. Gogo, MD Reviewer: American Journal of Cardiology and Coronary Disease

Rony Lahoud, MD Editorial Board: Cardiovascular Revascularization Medicine

Martin M. LeWinter, MD Section Editor: Myopericardial Disease, Up-To-Date Editorial Boards: Circulation, Heart and Vessels, Experimental and Clinical Cardiology, Cur- rent Cardiology Reviews, Heart Failure Reviews

Daniel Lustgarten, MD Editorial Board: Journal of Innovations in Cardiac Rhythm Management

Richard L. Page, MD Editorial Board: American Heart Journal

Section Editor: Cardiac Arrhythmias, Up-To-Date

Peter Spector, MD Editorial Board: Journal of Cardiovascular Electrophysiology

Marc D. Tischler, MD Ad Hoc Reviewer: American Journal of Cardiology, Journal of American College of Cardiol- ogy, Journal of American Society of Echocardiography

Michael J. Toth, PhD Editorial Boards: American Journal of Physiology-Endocrinology and Metabolism, Journal of Cellular Biochemistry.

Study Sections, National Advisory Boards, National/International Invited Talks

Harold L. Dauerman, MD Data Safety and Monitoring Board for 5 National trials of renal denervation, percutaneous mitral intervention, percutaneous tricuspid intervention and coronary atherectomy Via the Harvard Clinical Research Institute and the Cardiovascular Research Foundation.

Rony Lahoud, MD Society of Cardiac Angiography and Intervention, Invited Speaker at 2019-2020 Annual Meet- ings

Martin M. LeWinter, MD Consultant, Kiniksa Therapeutics Consultant, SOBI Orphan Therapeutics “Acute and Recurrent Pericarditis”, lecture for Kiniksa Therapeutics sponsored conference

Richard L. Page, MD FDA Circulatory System Devices Panel, Past-Chair

Michael J. Toth, PhD National Institutes of Health, ZRG1 F10B-B, Ad hoc

Major Faculty Honors and Awards

Sherrie Khadanga, MD American Association of Cardiovascular and Pulmonary Beginning Investigator Award 2019 Selected for the American College of Cardiology Leadership Academy Cohort IV

Michael J. Toth, PhD Distinguished Investigator, Cardiovascular Research Institute of Vermont

Grants

Philip A. Ades, MD NIH: The National Institute of General Medical Sciences: Vermont Center on Behavior and Health (COBRE Grant). P20GM103644 Role: Associate Director

Case Management vs Financial Incentives on Cardiac Rehabilitation Participation in Low SES Individuals. R33HL143305 Role: Co-Principal Investigator

Harold L. Dauerman, MD Impact of Nitric Oxide Generation on Acute Kidney Injury (with R. Solomon and R. Lahoud): Funded by Sonogenix, 49,000 dollars.

RUC-4, a novel intravenous antiplatelet agent, for patients with ST elevation myocardial infarction. A Phase II Trial. Sponsored by Celecor. Role: National Steering Committee

ACURATE NEO: A 3rd Generation TAVR valve pivotal trial. Sponsored by Boston Scientific. Role: Site principal investigator. Grant funding 250,000 dollars

EVOLVE SHORT DAPT,A National Registry of 3 Months Dual Antiplatelet Therapy in Con- junction with SYNERGY Bioresorbable Polymer Drug Eluting Stent for Patients at High Risk of Bleeding, National Steering Committee. Funded by Boston Scientific. Role: Site Principal Investigator. Grant funding 300,000 dollars

Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure: a randomized trial (TAVR UNLOAD. Funded by Edwards. Role: Site principal investigator. Grant funding 250,000 dollars

CoreValveTranscatheter Aortic Valve Replacement in Patients at Low Risk for Surgical Aortic Valve Replacement. Funded by Medtronic. Role: Site principal investigator. Grant funding 250,000 dollars

Friederike Keating, MD NIH 1U01HL133817-01 Myocardial Ischemia and Transfusion (MINT) Role: Site Principal Investigator

Robert J. Kelm, Jr., PhD Atomwise, Inc. AIMS Award A19-363 Identification of Small Molecules Targeting Purine-Rich Element Binding Protein B Role: Principal Investigator

UVM Cancer Center Pilot Project 2020

Evaluation of Purine-Rich Element Binding Protein B as a Druggable Target in Cancer Therapy Role: Principal Investigator

Sherrie Khadanga, MD VCBH COBRE Pilot study P20GM103644 (awarded $50k) for 2018 to 2020

VCBH COBRE P20GM103644 ($250k/year) Role: Project Director

CVRI Early Career Grant ($9500) Role: Principal Investigator

Rony Lahoud, MD XIENCE 90: A Safety Evaluation of 3-month DAPT After XIENCE Implantation for HBR patients Role: Site Principal Investigator

Shockwave Medical, Inc. SHOCKWAVE Coronary Lithoplasty Study (Disrupt CAD II) Role: Site Principal Investigator

Martin M. LeWinter, MD NIH RO1 HL118524 Myofilament Basis of Diastolic Dysfunction in HFpEF Role: Principal Investigator

Rilonacept Inhibition of Interleukin-1 Alpha and Beta for Recurrent Pericarditis: A Pivotal Symptomatology

Daniel L. Lustgarten, MD, PhD Cross X4 15-406: Evaluate the presence of PNS in pts who receive a BSCI device with SJM LV Lead Role: Sub Principal Investigator

PSR M09-167: Product Surveillance Registry Role: Sub Principal Investigator

Protego DF4 15-353: Determine the effectiveness of Biotronik’s DF4 lead Role: Principal Investigator

Quadripolar Pacing Post Approval Study M13-013: Evaluate the acute and chronic performance of a Quadripolar CRT-D device system in a patient population indicated for cardiac resynchroni- zation therapy Role: Principal Investigator

TEMPO 15-008: To evaluate the effect of GS-6615 compared to placebo on the overall occur- rence of appropriate ICD interventions (antitachycardia pacing [ATP] or shock) in subjects with ICD or CRT-D during the first 24 weeks of treatment Role: Principal Investigator

MR-HIS 16-244: Retrospective multicenter analysis of His bundle pacing outcomes Role: Principal Investigator

HIS Bundle Pacing Registry 00000048: The HBP Registry is a prospective, observational, multicenter registry Role: Principal Investigator

Peter S. Spector, MD UVM Spark award “Seeing Atrial Fibrillation through a clearer lens” Role: Principal Investigator

Michael J. Toth, PhD NIH R01 AR065826 Skeletal Muscle Atrophy and Dysfunction in Human Cancer Role: Principal Investigator

NIH R01 AG050305 Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty Role: Principal Investigator

Matthew W. Watkins, MD Capricor, Inc. Randomized, Double-Blind, Placebo-Controlled Phase I/II Study of the Safety and Efficacy of Intracoronary Delivery of Allogeneic Cardiosphere-Derived Cells in Patients With an Anterior Myocardial Infarction and Ischemic Left Ventricular Dysfunction (ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration, ALLSTAR) – Enrollment ongoing Role: Site Principal Investigator

NIH/Renova Therapeutics Adenovirus Vector Type 5 (Ad5.hAC60 Expressing Human Adenylyl Cyclase Type 6) Adminis- tered via Intracoronary Catheterization – enrollment completed 2014, study ongoing Role: Site Principal Investigator

Joseph Winget, MD AdaptResponse 15-066: Test the AdaptivCRT algorithm in CRT indicated patients Role: Principal Investigator

QP Excel 17-0163: Confirm safety and effectiveness of the Sentus QP LV lead and BIO- TRONIK CRT-D. Role: Principal Investigator

Publications

Ades, P. A., Balady, G. J., Berra, K., Franklin, B. A., Froelicher, V., Hamm, L. F., Kaminsky, L. A., & Williams, M. A. (2020). The Journal of Cardiopulmonary Rehabilitation and Prevention at 40 Years and Its Role in the Evolution of Cardiac Rehabilitation. Journal of cardiopulmonary rehabilitation and prevention, 40(1), 2–8. https://doi.org/10.1097/HCR.0000000000000494

Anderson CJ, Phuong NS, Mayhew CR, Dauerman HL, Tsai MH, Martin JA. Retrospective single center comparison of transcatheter aortic valve replacement cost per minute using general anesthesia versus sedation. 2020. J Clin Anesth. 2020;66:109957. doi:10.1016/j.jcli- nane.2020.109957

Balady GJ, Ades PA. ECG Stress Testing, in, Braunwald Textbook of Cardiology, 12th Edition, Saunders, 2020.

Cooper, K. M., Barrett, T., McBride, C. A., Badger, G. J., Steiner, J., LeWinter, M. M., & Bern- stein, I. M. (2019). Subclinical cardiac stiffness is associated with arterial stiffness in healthy young nulligravid women: Padotential links to preeclampsia. Pregnancy hypertension, 18, 49–54. https://doi.org/10.1016/j.preghy.2019.09.001

Coylewright, M., O'Neill, E., Sherman, A., Gerling, M., Adam, K., Xu, K., Grande, S. W., Dau- erman, H. L., Dodge, S. E., Sobti, N. K., Saunders, C. H., Schott, S. L., Elwyn, G., & Durand, M. A. (2020). The Learning Curve for Shared Decision-making in Symptomatic Aortic Stenosis. JAMA cardiology, 5(4), 442–448. https://doi.org/10.1001/jamacardio.2019.5719

Dauerman HL. Darkness on the Edge of Thrombolysis. J Am Coll Cardiol. 2020;75(12):1422- 1425. doi:10.1016/j.jacc.2020.02.007

Dauerman HL. RESPONSE: Cardiovascular Education Scholars: A New Pathway to Promo- tion. J Am Coll Cardiol. 2019;74(18):2325. doi:10.1016/j.jacc.2019.09.032

Dauerman HL, Solomon RJ. Innocent, Guilty, and Acute Kidney Injury. J Am Coll Cardiol. 2020;75(11):1321-1323. doi:10.1016/j.jacc.2020.01.022

Dittus K, Toth M, Priest J, O'Brien P, Kokinda N, Ades P. Effects of an exercise-based oncology rehabilitation program and age on strength and physical function in cancer survivors. Support Care Cancer. 2020;28(8):3747-3754. doi:10.1007/s00520-019-05163-8

Ehtisham Mahmud, Harold L. Dauerman, Frederick GP Welt et al. Management of Acute Myo- cardial Infarction During the COVID-19 Pandemic. J Am Coll Cardiol April, 2020; DOI: 10.1016/j.jacc.2020.04.039

Gaalema, D. E., Dube, S., Potter, A., Elliott, R. J., Mahoney, K., Sigmon, S. C., Higgins, S. T., & Ades, P. A. (2019). The effect of executive function on adherence with a cardiac secondary prevention program and its interaction with an incentive-based intervention. Preventive medicine, 128, 105865. https://doi.org/10.1016/j.ypmed.2019.105865

Gaalema, D. E., Elliott, R. J., Savage, P. D., Rengo, J. L., Cutler, A. Y., Pericot-Valverde, I., Priest, J. S., Shepard, D. S., Higgins, S. T., & Ades, P. A. (2019). Financial Incentives to In- crease Cardiac Rehabilitation Participation Among Low-Socioeconomic Status Patients: A Ran- domized Clinical Trial. JACC. Heart failure, 7(7), 537–546. https://doi.org/10.1016/j.jchf.2018.12.008

Gaalema, D. E., Savage, P. D., Leadholm, K., Rengo, J., Naud, S., Priest, J. S., & Ades, P. A. (2019). Clinical and Demographic Trends in Cardiac Rehabilitation: 1996-2015. Journal of cardiopulmonary rehabilitation and prevention, 39(4), 266–273. https://doi.org/10.1097/HCR.0000000000000390

Genuth, S. M., Vlachos, H., Brooks, M. M., Bantle, J. P., Chaitman, B. R., Green, J., Kelsey, S. F., King, S. B., 3rd, McBane, R., Sako, E. Y., Schneider, D. J., Steffes, M., Frye, R. L., & BARI 2D Study Group (2019). BARI 2D: A Reanalysis Focusing on Cardiovascular Events. Mayo Clinic proceedings, 94(11), 2249–2262. https://doi.org/10.1016/j.mayocp.2019.04.015

González-Roz A, Gaalema DE, Pericot-Valverde I, Elliott RJ, Ades PA. A Systematic Review of the Diagnostic Accuracy of Depression Questionnaires for Cardiac Populations: IMPLICA- TIONS FOR CARDIAC REHABILITATION. J Cardiopulm Rehabil Prev. 2019;39(6):354-364. doi:10.1097/HCR.0000000000000408

Guigni BA, Fix, DK, Bivona JJ, Palmer BM, Carson JA, Toth MJ. Electrical stimulation pre- vents doxorubicin-induced atrophy and mitochondrial loss in chemotherapy on skeletal muscle via mechanotransductive pathways. Am J Physiol Cell Physiol 317: C1213-C1228, 2019

Guigni BA, van der Velden, Kinsey CM, Carson JA, Toth MJ. Effects of murine and human lung tumor cell conditioned media on cultured myotubes. Am J Physiol Cell Physiol 318: E22-E32, 2020

Gurchiek RD, Choquette RH, Beynnon BD, Slauterbeck JR, Tourville TW, Toth MJ, McGinnis RS. Wearable sensor-based remote gait analysis detects altered duty factor and phase specific quadriceps muscle activation in patients recovering from ACL reconstructive surgery. Sci Rep 9: 17966, 2019

Hopkins, WE, Golper, TA, Beathard, GA. Pulmonary hypertension in hemodialysis patients. In: UpToDate, Post, TW (Editor-in-Chief), Wolters Kluwer Health 2019.

Khadanga S, Savage PD, Ades PA. Resistance Training for Older Adults in Cardiac Rehabilita- tion. Clin Geriatr Med. 2019;35(4):459-468. doi:10.1016/j.cger.2019.07.005

Kshitiz, Ellison, D. D., Suhail, Y., Afzal, J., Woo, L., Kilic, O., Spees, J., & Levchenko, A. (2019). Dynamic secretome of bone marrow-derived stromal cells reveals a cardioprotective biochemical cocktail. Proceedings of the National Academy of Sciences of the United States of America, 116(28), 14374–14383. https://doi.org/10.1073/pnas.1902598116

Lahoud, R; Butzel DW, Parsee A; Huang YL, Solomon RJ, DeVries JT; Flynn JM; Iribarne A, Ver Lee P, Ross CS; Malenka DJ; Dauerman HL for the Northern New England Cardiovascular Disease Study Group. Acute Kidney Recovery in Patients Undergoing Transcatheter Versus Sur- gical Aortic Valve Replacement. Am J Cardiol 2020; 125:785-794.

Lahoud R, Dauerman HL. Fall and Rise of Coronary Intervention. J Am Heart Assoc. 2020;9(11):e016853. doi:10.1161/JAHA.120.016853

Lustgarten DL, Rajagopal G, Reiland J, Koehler J, Sarkar S. Premature ventricular contraction detection for long-term monitoring in an implantable cardiac monitor. Pacing Clin Electrophys- iol. 2020;43(5):462-470. doi:10.1111/pace.13903

Malasana, GR, Zeglin M, McElveen, R. Transcatheter Aortic Valve Replacement in Dextrocar- dia With Situs Inversus. J Am Coll Cardiol Case Rep. 2020 Jun, 2 (6) 860-861.

McMahon SR, Chava S, Taatjes-Sommer HS, Meagher S, Brummel-Ziedins KE, Schneider DJ. Variation in platelet expression of FcγRIIa after myocardial infarction. J Thromb Thrombolysis. 2019;48(1):88-94. doi:10.1007/s11239-019-01852-7

Meyer M, LeWinter MM. Heart Rate and Heart Failure With Preserved Ejection Fraction: Time to Slow β-Blocker Use?. Circ Heart Fail. 2019;12(8):e006213. doi:10.1161/CIRCHEARTFAIL- URE.119.006213

Murach KA, Dungan CM, Kosmac K, Voigt TB, Tourville TW, Miller MS, Bamman MM, Pe- terson CA, Toth MJ. Fiber typing human skeletal muscle with fluorescent immunohistochemis- try. J Appl Physiol 127: 1632-1639, 2019

Nambiar L, Silverman D, Vanburen P, LeWinter M, Meyer M. Beta-Blocker Cessation in Stable Outpatients With Heart Failure With a Preserved Ejection Fraction. J Card Fail. 2020;26(3):281- 282. doi:10.1016/j.cardfail.2019.08.020

Nambiar L, Lewinter MM, VanBuren PC, Dauerman HL Recent Trends in Hypertension Related Cardiovascular Deaths in the United States. Journal of the American College of Cardiology, 2020; 75: 2644-2646.

Nambiar L, LeWinter MM, VanBuren PC, Dauerman HL. Decade Long Temporal Trends in U.S. Hypertension Related Cardiovascular Mortality. J Am Coll Cardiol. 2020 eprint.

Palmer BM, Swank DM, Miller MS, Tanner BCW, Meyer M, LeWinter MM. Enhancing diastolic function by strain-dependent detachment of cardiac myosin crossbridges. J Gen Physiol. 2020;152(4):e201912484. doi:10.1085/jgp.201912484

Pericot-Valverde, I., Elliott, R. J., Priest, J. S., Barret, T., Yoon, J. H., Miller, C. C., 3rd, Okoli, C., Haliwa, I., Ades, P. A., & Gaalema, D. E. (2019). Patterns of tobacco use among smokers prior to hospitalization for an acute cardiac event: Use of combusted and non-combusted products. Preventive medicine, 128, 105757. https://doi.org/10.1016/j.ypmed.2019.105757

Ray KK, Colhoun HM, Szarek M, Baccara-Dinet M, Bhatt DL, Bittner VA, Budaj AJ, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Loizeau V, Lopes RD, Moryusef A, Mu- rin J, Pordy R, Ristic AD, Roe MT, Tuñón J, White HD, Zeiher AM, Schwartz GG, Steg PG; ODYSSEY OUTCOMES Committees and Investigators. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial. Lancet Diabe- tes Endocrinol. 2019 Aug;7(8):618-628. doi: 10.1016/S2213-8587(19)30158-5.

Reddy, Y., Lewis, G. D., Shah, S. J., Obokata, M., Abou-Ezzedine, O. F., Fudim, M., Sun, J. L., Chakraborty, H., McNulty, S., LeWinter, M. M., Mann, D. L., Stevenson, L. W., Redfield, M. M., & Borlaug, B. A. (2019). Characterization of the Obese Phenotype of Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study. Mayo Clinic proceedings, 94(7), 1199–1209. https://doi.org/10.1016/j.mayocp.2018.11.037

Schneider DJ. Platelet Function Testing and Clinical Outcomes: Connecting the Dots. JACC Basic Transl Sci. 2019;4(7):776-777. Published 2019 Nov 25. doi:10.1016/j.jacbts.2019.09.007

Schneider DJ, McMahon SR, Ehle GL, Chava S, Taatjes-Sommer HS, Meagher S. Assessment of Cardiovascular Risk by the Combination of Clinical Risk Scores Plus Platelet Expression of FcγRIIa. Am J Cardiol. 2020;125(5):670-672. doi:10.1016/j.amjcard.2019.12.008

Shukla, M., Callas, P. W., Lahiri, J. A., Alef, M. J., Keating, F. K., Stanley, A. C., Steinthorsson, G., Schneider, D. J., & Bertges, D. J. (2019). Surveillance and Management of Troponin Eleva- tion after Vascular Surgery. Annals of vascular surgery, 60, 156–164. https://doi.org/10.1016/j.avsg.2019.02.025

Spector, PS. (2019). Understanding Atrial Fibrillation. Wiley-Blackwell. ISBN: 978-1-119- 52460-1

Stevens T, McGinnis RS, Hewgill B, Choquette RH, Tourville TW, Harvey J, Lachapelle R, Toth MJ, Skalka C. Cyber physical system for near real-time monitoring of at-home rehabilitation and mHealth-based provider-patient communications to improve adherence: development and formative evaluation. JMIR:Hum Fact 7: e16605, 2020

Straight, C. R., Voigt, T. B., Jala, A. V., Chase, J. D., Ringham, O. R., Ades, P. A., Toth, M. J., & Miller, M. S. (2019). Quadriceps Lipid Content Has Sex-Specific Associations With Whole- Muscle, Cellular, and Molecular Contractile Function in Older Adults. The journals of gerontol- ogy. Series A, Biological sciences and medical sciences, 74(12), 1879–1886. https://doi.org/10.1093/gerona/gly235

Toth MJ, Voigt TB, Tourville TW, Prior SM, Schlosberg AV, Forest TJ, Kaufman PA, Wood ME, tul Rehman H, Dittus K. Effects of neuromuscular electrical stimulation on skeletal muscle cell size and function in breast cancer patients receiving chemotherapy J Appl Physiol 128: 1654-1665, 2020. [PMC 7311687]

Toth MJ, Tourville TW, Voigt TB, Choquette RH, Anair BM, Falcone MJ, Failla MJ, Stevens- Lapsley JE, Endres NK, Slauterbeck JR, Beynnon BD. Utility of neuromuscular electrical stimulation to preserve quadriceps size and function at the cellular level following anterior cruciate ligament injury and reconstruction: a randomized, sham-controlled, blinded trial. Am J Sports Med (in press) PMID: 32631074

Voigt T, Tourville TW, Falcone M, Slauterbeck JM, Beynnon BD, Toth MJ. Resistance training- induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults. BMC Res Notes 18: 595, 2019

Wahlberg K, Arnold ME, Lustgarten D, Meyer M. Effects of a Higher Heart Rate on Quality of Life and Functional Capacity in Patients With Left Ventricular Diastolic Dysfunction. Am J Car- diol. 2019;124(7):1069-1075. doi:10.1016/j.amjcard.2019.07.008

Weissman, G., Arrighi, J. A., Botkin, N. F., Damp, J. B., Keating, F. K., Menon, V., Rose-Jones, L. J., Singh, H. S., Soukoulis, V., & Kates, A. M. (2020). The Impact of COVID-19 on Cardio- vascular Training Programs: Challenges, Responsibilities and Opportunities. Journal of the American College of Cardiology, S0735-1097(20)35680-1. https://doi.org/10.1016/j.jacc.2020.06.026

Division of Dermatology

Glenn Goldman, MD, Director http://www.med.uvm.edu/medicine/Dermatology

Dermatology at the University of Vermont Medical Center is a division of the Department of Medicine. Our division employs six general dermatologists, four surgical dermatologists, a pediatric dermatologist and five experienced physician assistants. We provide general dermatology care to the community as well as specialized consultation with particular strengths in the treatment of psoriasis, cutaneous lupus, dermatomyositis, cutaneous lymphoma, and all forms of skin cancer including melanoma. In 2019 we saw 35,648 patients and generated 74,979 wrRVU. The COVID pandemic slowed our services for two months, but we are now back full steam seeing patients.

This year we said goodbye to Julie Lin and Laura McGevna, both of whom joined private practices in the community. We work with them regularly. Dr. Lin has remained on in her EPIC / EMR role for the De- partment of Medicine.

The COVID pandemic necessitated the rapid rollout of teledermatology services. We have found telemedicine visits provide excellent care for follow-up care, pediatric dermatology, psoriasis, dermatitis and numerous other skin diseases. Because of the hands on nature of dermatology, most visits are still performed in person, and we are back to full schedules.

We have hired two new physicians and one new physician assistant. Dr. Julia Barker splits her time between the UVMMC and CVMC in Berlin. Dr. Evan Piette provides services at the UVM Medical Center main campus and will soon provide services at Porter Medical Center in Middlebury. Our new physician assistant, Morgan Rogers, has hit the ground running with a full schedule to accommodate new and returning patient visits.

Dr. Glenn Goldman is the President of the American College of Mohs Surgery. He also serves on the Board of Directors of the American Society for Dermatologic Surgery where he is Chair of the Interna- tional Travelling Mentorship Program. This year he was granted an endowed Professorship and is now the Follansbee Professor of Dermatology at the UVM College of Medicine. He was also appointed Chair of the Coding and Reimbursement Committee of the American Academy of Dermatology.

Dr. Todd Holmes was promoted to Full Professor in recognition of his ongoing and outstanding academic contributions. He remains heavily engaged in the surgical training of our residents and fellows. He is the Chair of the International Fellowship Training Program of the American Society for Dermatologic Sur- gery. He is very active on multiple committees with a special interest in the Operations Committee.

Joseph Pierson, MD is the Dermatology Residency Director. He provides a very high level of academic service, serving on one committee for the UVMMC, four committees for the Department of Medicine, and three committees within dermatology. He is currently engaged in the diversity and inclusion task

46 force for the Department of Medicine. Dr. Pierson publishes broadly and has been appointed to the Edi- torial Board of the American Academy of Dermatology. He was the lead author of a “top ten” article this year! He is very active in the Association of Professors in Dermatology.

Christine Weinberger, MD was promoted to Associate Professor of Medicine. She is developing a collaboration with a local dermatology group to provide Mohs micrographic surgery in an office setting.

Dr. Melanie Bui is our most active research dermatologist and is exceptionally-dedicated to student and resident research. In the last three years she has mentored 17 medical students. She is our quality leader and this year during the pandemic she initiated can completed a far-reaching overhaul of our melanoma staging, tracking and followup system. She is engaged in multiple committees at the medical center, regionally and nationally. Dr. Bui has taken on our public face with multiple appearances in the local media for public education about sun and the skin as well as women’s dermatological issues. In the past year she and our students and residents had 12 posters, presentations and virtual presentations.

Dr. Keith Morley continues to offer broad ranging pediatric dermatology services. He provides pulsed dye laser treatment of vascular birthmarks, simple excisions, and diagnostic skin biopsies with sedation in the Comfort Zone if needed. He lectures broadly in the community. Dr. Morley continues as a Pediatric Contributing Editor for Visual Dx, a patient and physician-centered telehealth and public health web-based application. He serves on the Society of Pediatric Dermatology’s Education Committee and the Maintenance of Certification Committee. This year he was appointed to the Advisory Board Representative of the Vermont Dermatology Society to the American Acad- emy of Dermatology (AAD). As always he will be volunteering with Camp Discover, a camp for children with chronic skin conditions. Dr. David Chen focuses on Mohs surgery. He has taken over and revamped the entire dermatology medical school curriculum and has added defined metrics to improve the experience.

Dr. Ankit Gor sees patients both at UVMMC and in Plattsburgh at CVPH. He has facilitated NY state telehealth services and is working with the E-consult team to improve the process for outside consultations.

Each month we host medical students for clinical or research rotations in dermatology. On average one or two University of Vermont medical students per year choose to enter the field of dermatology. Due to the tremendously-competitive nature of dermatology as a specialty, each student requires careful guidance and assistance in procuring a residency. As usual, last year our two UVM students interested in dermatology matched at excellent training programs.

We continue to volunteer regularly at the Community Health Center Free Clinic. Each month, an attending physician supervises the residents and Physician Assistants in the provision of free care to patients at the Community Health Center in Burlington. This provides a service to the community and is also a superior experience for our residents and fellow, who are able to participate in the care of an underserved population.

Faculty Glenn Goldman, MD Rogers and Nancy Follansbee Professor of Medicine Director, Dermatology Division Director, Mohs Surgery and Dermatologic Oncology Fellowship President, American College of Mohs Surgery Board of Directors, American Society for Dermatologic Surgery

Mohs Surgery and Reconstructive Surgery Management of high-risk skin cancers Cosmetic Dermatology Procedural Dermatology Education National Health Care Policy Continuing Medical Education International Dermatologic Surgery

Todd Holmes, MD Professor of Medicine Surgical Dermatology and Cutaneous Oncology Mohs and Reconstructive Surgery Resident and Fellow Education International Education in dermatologic surgery

Christine Weinberger, MD Associate Professor of Medicine Mohs Surgery and Reconstruction Mohs Surgery for Melanoma Skin Cancer in Solid Organ Transplant Recipient

Joseph Pierson, MD, Col US Army Associate Professor of Medicine General Medical Dermatology Residency Education in Dermatology Diversity and Inclusion

Melanie Bui, MD, PhD Assistant Professor of Medicine General Medical Dermatology Immunology Dermatology Research

David Chen, MD Assistant Professor of Medicine Mohs Surgery and Reconstruction Cosmetic Dermatology Medical Student Education

Keith Morley, MD

Assistant Professor of Medicine Pediatric Dermatology Pediatric Laser Surgery

Ankit Gor, MD Assistant Professor of Medicine  General and Surgical Dermatology  CVPH Plattsburgh Outreach

Aliza Fischer, MD Assistant Professor of Medicine  General and Surgical Dermatology  CVMC Berlin Outreach

Julia Barker, MD Assistant Professor of Medicine  General and Surgical Dermatology  CVMC Berlin Outreach

Evan Piette, MD Assistant Professor of Medicine  General and Surgical Dermatology  Teledermatology  Middlebury Outreach

Fellow MSDO 2020-2021 Julien Lanoue, MD, PGY-5

Residents Lucy Ledyard, MD, PGY-4 Alexandra Charos, MD, PGY-4 Daniel Bax, MD, PGY-3 Dustin Taylor, MD, PGY-3 Carli Whittington, MD, PGY-3 Santana VanDyke, MD, PGY-2 Nate Bombardier, MD, PGY-2

Physician Assistants:

Deb Roseman, PA: Deb has been with us for over 15 years. She has decades of experience as a dermatology physician assistant and has a following of thousands of patients for whom she provides care. She is active in teaching students and in mentoring those with potential interest in becoming physician assistants.

Anne Klein, PA Anne is a surgical PA, and works with the dermatologic surgeons daily. She trained for years with a plas- tic surgeon and has exceptional procedural skills. A testament to her skill is that physicians refer patients

49 to her regularly for surgical excisions. She is also active in teaching students and in mentoring those with potential interest in becoming physician assistants.

Rich Callahan, PA Rich is experienced in dermatology and provides both medical and minor surgical dermatology care. He brings with him many patients from his former practice. Rich has a particular interest in dermoscopy and has championed the use of this technique for the evaluation of pigmented lesions.

Emilie Rainville, PA Emilie was our medical assistant prior to going to PA school. She has trained with us and hits the ground running with a strong background in dermatology.

Morgen Rogers, PA Morgen is our newest PA. She started out in dermatology as a medical assistant and we are very pleased to have her back on our team as a physician assistant.

Endowed Professorships Glenn Goldman, M.D. Rogers and Nancy Follansbee Professorship in Dermatology

Editorships and Editorial Boards

Dr. Morley Editor for Pediatric Section of VisualDx Dr. Pierson Editorial Board, Journal of the American Academy of Dermatology

Institution Service Dr. Goldman Chair, Medicine Credentials Committee

Leadership in Professional Societies:

Vermont Dermatologic Society

Dr. Goldman President Dr. Bui Treasurer

American Academy of Dermatology Dr. Goldman Chair of the Coding and Reimbursement Committee

American Society for Dermatologic Surgery Dr. Goldman Board of Directors Dr. Goldman Chair of the ASDS International Traveling Mentorship Committee Dr. Holmes Chair of the ASDS ITMP Fellowship Subcommittee Dermatology Foundation Dr. Goldman Leader’s Society State / Regional Chair Dr. Pierson Leader’s Society State / Regional Vice Chair

American College of Mohs Surgery Dr. Goldman President

Faculty, Resident and Fellow Peer-Reviewed Publications

Alniemi DT, Kanner C, Stowman AM, Knapp M, McGevna L, Seward DJ, Bui MR. Diagnosing Calciphylaxis: A series of cases with both imaging and tissue biopsy. Journal of the American Academy of Dermatology. 2020 Jun 8. Alniemi DT, Green L, Bui M. Spiky papules on the dorsal feet. Cutis 2020;105:123-125. PMID 32352436 Alniemi DT, et al., Bui MR, Diagnosing Calciphylaxis: A series of cases with both imaging and tissue biopsy. J Am Acad Dermatol 2020;S0190-9622 epub ahead of print

Chen DL, et al, Goldman GD, et al. Multidisciplinary tumor boards in dermatologic surgery. Dermatol Surg 2019 Potter KA, Charos E, Chen DL. Repair of a deep auricular wound. Dermatol Surg 2019;epub ahead of pring Howe NM, Chen DL, Holmes TE. Cresecentic modification to island pedicle rotation flaps for defects of the distal nose. Dermatol Surg 2019;45:1163-1170.

Gor A, Goldman GD, Chen DL. Point-of-view dermatologic surgery video recording. Dermatol Surge 2019 Oct: Ahead of print

Alniemi DT, DeWitt C, Goldman GD, Holmes TE. Single-sling island pedicle flap with bilevel undermining for repair of superior helical rim defects. Dermatol Surg 2019. PMID 31688235

Norris II, Weinberger CH, Holmes TE, Goldman GD. Mohs micrographic surgery for advanced centrofacial tumors. Dermatol Surg 2019:45S79-S98.

Pierson JC, Tegeder AR, Lesiak K. Multiple Lesions of Erythema Migrans in a "Christmas Tree" Pattern as a Present- ing Sign of Lyme Disease. J Am Acad Dermatol. 2019 Aug;81(2):e23-e24. PMID: 31307694

Loyal J, Farrell E, Pierson JC. Atretic Cephalocele with Hypertrichosis – Case Report, Differential Diagnosis, and Workup. Cutis. (Accepted)

Tkachenko E, Vleugels R, Pierson JC. Porphyria Cutanea Tarda Masquerading as Systemic Sclerosis: Two Cases Demonstrating an Important Clinical Observation. J Rheumatol (Accepted)

Shea K, Cook D, Pierson J. Telangiectatic patch on the forehead of a middle-aged man. Cutis (Accepted) Gabel C, Nguyen E, Karmouta R, Pierson J, et al. Use of teledermatology by dermatology hospitalists is effective in the diagnosis and management of inpatient disease. J Am Acad Dermatol. 2020 May 7:S0190-9622(20)30831-8. PMID: 32389716

Knapp M, Carpenter CE, Shea K, Stowman A, Pierson JC. Focal Dermal Elastosis: a Proposed Update to the Nomen- clature. Am J Dermatopathol. Am J Dermatopathol. 2020 May 28. PMID: 32472772

Division of Endocrinology and Diabetes Joel J. Schnure, MD, Director http://www.med.uvm.edu/medicine/endocrinology

The 2019-2020 academic year continued the trend of increased research and patient care opportunities for the Division of Endocrinology and Diabetes. The Division serves the residents of Vermont and upstate New York with a goal of delivering seamless, system-wide care within the University of Vermont Health Network for endocrine-related disorders. Our 8 physicians, 2 nurse practitioners, and 3 certified diabetes educators provide consultative and ongoing care through our outpatient clinic at Tilley Drive, which has approximately 14,000 visits per year (4th in the Department of Medicine); the Division also operates a consult service at the UVM Medical Center and continues to develop outreach endocrine services at our Network partner hospitals, CVPH in Plattsburgh, NY and Central Vermont Medical Center, Berlin, VT. In addition, we continue to expand our telemedicine program delivered in conjunction with Northwest Medical Center in Saint Albans, VT. The Division continues to make progress in expanding services to patients in the areas of osteoporosis/metabolic bone disease under the aegis of Jennifer Kelly, DO, Director of the Osteoporosis/Metabolic Bone Disease Clinic. Dr. Kelly, a renowned clinician and researcher in the area of metabolic bone disease, joined our faculty in 2017. Working with Dr. Elizabeth Ames from Orthopedics, they are establishing a fracture liaison service for patients to receive proper evaluation and treatment after sustaining an osteopathic fracture. The DXA Bone Density Machine moved into the Endocrinology clinic on Tilley Drive in early 2020. This has increased our ability to focus on screening and prevention for at-risk patients. Dr. Kelly is also involved in a research project with Dr. David Lunardini from Ortho- pedics that examines the use of abaloparatide in healing C2 fractures. Kaitlyn Barrett, DO joined our faculty in mid-August following completion of her Fellowship in Endocrinology and Diabetes with the Division. As the Division’s newest Assistant Professor, Dr. Barrett continues the excellent patient care and education of trainees that she demonstrated during her fellowship; she also is active in our metabolic bone disease enterprise and implemented our Division’s outpatient telemedicine initiative with North- western Medical Center in St. Albans in October 2019. With our existing expertise in telemedicine we have been able to successfully establish a robust and enhanced telemedicine practice with social distancing due to the restrictions placed upon our system because of the Covid-19 pandemic. Our research initiatives continue at both the clinical and basic levels. Dr. Matthew Gilbert leads the way in clinical trials. He and his collaborators are working on cardiovascular outcome trials with oral GLP-1RAs, analysis of cardiovascular outcome trials with GLP-1 RA and SGLT2 in the elderly, and the use of GLP-1 RA in patients with renal insufficiency. Data from a Division-initiated analysis of the cost-effectiveness of inpatient diabetes consultation (Drs. Schnure and Kelsey Sheahan (our 2nd year Fellow)) was presented at the American Diabetes Association meeting in June and has been submitted for publication. The study has shown a substantial decrease in length of stay in patients who receive an early Endocrine consultation. Other ongoing clinical research projects, including a study investigating the various treatment modalities for enteral and parenteral feeding for inpatients (Drs. Gilbert and Barrett) are proceeding. The Division’s basic research efforts with Drs. Tom Jetton and Jay Gupta continue to focus on pancreatic islet biology, diabetes, and metabolic disease and, in collaboration with Jana Kraft, PhD, on the effects of bioactive lipids on gut microbiota eubiosis, energy metabolism, and aging. Dr. Kraft is a lipid biochemist with expertise in human nutrition; in addition to her basic research with Drs. Jetton and Gupta, she is collaborating with Matthew Gilbert, DO, MPH on a clinical study of dietary dairy lipids and diabetes risk. Our faculty participate in educational activities at multiple levels. Clinical faculty work closely with medical students and residents rotating through the Endocrine Service and they train two Fellows in Endocrinology each year. Dr. Kelly supervises the Metabolic Bone Conference series and ensures the quality and diverse topic range of this monthly lecture program. She also works with Drs. Nathan and Gilbert to be sure that the Endocrine lectures

52 provided weekly to Endocrine fellows, faculty, and staff are focused on a wide range of Endocrine pathologies and provide the most up-to-date standards of care. The Division’s educational mission is also evidenced by faculty participation in LCOM initiatives, including Dr. Schnure and Dr. Kelly’s service with The Teaching Academy, which promotes education and scholarship of faculty members. The faculty’s medical education focus also extends beyond UVM/UVMMC through CME-accredited, day- long conferences available to healthcare providers in our region. Dr. Kelly was the course director for and a presenter at “Osteoporosis Update for Primary Care,” held in September 2019; Dr. Barrett also presented a program at this conference. Dr. Schnure was the course director for the “2nd Annual Diabetes for Primary Care Conference,” held in November 2019. This conference included local and nationally recognized experts in treating diabetes, heart disease, and peripheral neuropathy. Dr. Schnure was named by Dr Isabelle Desjardins, the Chief Medical Officer at UVMMC, to serve as chairman of the newly formed Diabetes Oversight Task Force. The Task Force has been charged with enhancing the care of our patients with diabetes throughout our network. The Task Force expedites the work of Dr. Gilbert, who continues to serve as Chair of the Inpatient Glycemic Control Committee, whose mission includes education of hospital physicians and staff on glucose management strategies. Dr. Jetton continues to serve as Director of the graduate course, Science Communication, which has become part of the required curriculum for the Cellular, Molecular and Biomedical Sciences Program. Dr. Jetton also continues to teach classes in human structure and function to medical students and was instrumental in updating of curriculum. He also works one-on-one in his lab to train undergraduate, graduate, and medical students in research techniques. Clearly, the 2019-2020 year was a busy, productive, and very challenging one for the Division of Endocrinology and Diabetes and the programmatic and research strides made this year ensure the continued effectiveness of our service and education missions.

Faculty

Joel J. Schnure, MD Professor of Medicine Director, Division of Endocrinology and Diabetes Chair, Diabetes Oversight Task Force, UVMMC Member, The Teaching Academy Member, DOM Operations and Efficiency Committee Lead, Diabetes Chronic Care Initiative Lead, Task Force on In-patient Diabetes Education Member, In-patient Diabetes Initiative Research and clinical interests: . Diabetes care for Type 1, Type 2, and diabetes in pregnancy . Thyroid disease . Pituitary disease . Integration of home glucose monitoring into electronic medical records . Fructosamine as an alternative to HbA1C in pregnancy . Web-based algorithms in titration of basal insulin in adults with Type 2 diabetes . HbA1c and fructosamine in early pregnancy: correlation to 24-28 week OGTT . Cost-effectiveness of endocrine consultation in inpatients with diabetes

Kaitlyn Barrett, DO Assistant Professor of Medicine Research and clinical interests: . Metabolic bone disease and osteoporosis . Thyroid disorders . Diabetes mellitus

Sree Susmitha Garapati, MD, FACE

Assistant Professor of Medicine Clinical interests: . In-patient and out-patient diabetes management . Thyroid disease, including thyroid ultrasound and biopsy . Adrenal and pituitary diseases . PCOS . Male hypogonadism

Matthew P. Gilbert, DO, MPH Associate Professor of Medicine Director, Endocrinology Fellowship Program Chairman, Inpatient Diabetes Management subcommittee of P and T Research and clinical interests: . Diabetes mellitus . Thyroid disorders . Thyroid cancer . Male hypogonadism

Dhananjay (Jay) Gupta, PhD Research Assistant Professor Research interests: . Pathogenesis of type 2 diabetes and islet biology . Epigenetic regulation of adaptive islet beta cell response with changing metabolic milieu

Thomas L. Jetton, PhD Professor of Medicine Research interests: . Nutrient and neural regulation of β-cell mass homeostasis . Diet influence on intestinal microbiota and autoimmune disease susceptibility Teaching interests: . Human Structure and Function . Gastrointestinal Physiology . Regulation of Energy Homeostasis . Science Communication

Jennifer Kelly, DO, FACE Associate Professor of Medicine Director of the Metabolic Bone Program Member, The Teaching Academy Research and clinical interests: . Osteoporosis . Metabolic bone disorders, including Paget’s Disease of Bone . Diabetes mellitus

John (Jack) L. Leahy, MD Professor of Medicine Sarah Nichols Gruenig Green & Gold Professor in Diabetes Research Co-Director, Division of Endocrinology and Diabetes Research and clinical interests: . Diabetes mellitus . Islet beta-cell physiology and dysfunction

Muriel H. Nathan, MD, PhD

Professor of Medicine Research and clinical interests: . Diabetes (including use of insulin pumps) and PCOS . Thyroid cancer, thyroid nodules, and hyper- and hypothyroidism . Pituitary tumors and dysfunction . Adrenal disorders, hirsutism . Inpatient improvement projects funded by the James M. Jeffords Institute for Quality ~ SQ and IV insulin forms, insulin pump, DKA

Juan Pablo Perdomo Rodriguez, MD Assistant Professor of Medicine Research and clinical interests: . Hyperthyroidism (overactive thyroid disorders) . Thyroid nodules and cancer . Cushing disease . Adrenal insufficiency in pregnancy . Hyperaldosteronism . Hyperparathyroidism and osteoporosis . Adrenal tumors

Fellows

Kelsey Sheahan, MD (F5, began training 8/28/2018; expected completion 11/20/2020) Amy Shah, DO, MPH (F5, began training 7/1/2019; expected completion 6/30/2021) Shreya Amin, MD (F4, will begin training 7/1/2020; expected completion 6/30/2022)

Nurse Practitioners and Certified Diabetes Educators

Margaret Costello, FNP, MS Ann Gotham, ANP, MSN, ScM Chassidy Deslauriers, MBA, RD, CDE Mary Spence, RN, CDE Linda Tilton, MS, RD, CDE

Graduate Students, Post-doctoral Fellows, MD PhD Students

None

Endowed Professorships

Sarah Nichols Gruenig Green & Gold Professor in Diabetes Research Held by John (Jack) L. Leahy, MD

Leadership in Professional Societies

Matthew P. Gilbert, DO, MPH Vermont Board of Osteopathic Physicians and Surgeons, Secretary as of November 2019

Dhananjay (Jay) Gupta, PhD American Diabetes Association American Society for Biochemistry and Molecular Biology Boston-Ithaca Islet Club

Thomas L. Jetton, PhD Boston-Ithaca Islet Club, senior member

Jennifer J. Kelly, DO, FACE National Osteoporosis Foundation, member of the Ambassadors Leadership Council American Association of Clinical Endocrinologists national organization: Task Force to Update the AACE/ACE Postmenopausal Osteoporosis Clinical Practice Guidelines Membership Committee, member Bone and Parathyroid Disease State Network Committee, member Thyroid Disease State Network Committee, member American Association of Clinical Endocrinologists, New England Chapter, Board of Directors International Society of Clinical Densitometry, Web Advisory Committee member New England Bone Club, 2018 and 2019 Annual Meeting Planning Committee member American Association of Clinical Endocrinologists (AACE) national organization, Bone and Parathyroid Disease State Network Committee member and Thyroid Disease State Network Committee member

Muriel H. Nathan, MD, PhD New England Thyroid Club, senior member

Editorships and Editorial Boards

Dhananjay (Jay) Gupta, PhD Editorial Board: Journal of Endocrinology, Diabetes and Obesity Reviewer: Diabetes, Diabetes Care, Science Reports, Journal of the Endocrine Society, Journal of Nutritional Bio- chemistry, Life Sciences, International Journal of Chronic Diseases

Thomas L. Jetton, PhD Reviewer: Diabetes, Endocrinology, PNAS, Metabolism, Diabetologia, American Journal of Physiology, PLosOne

John (Jack) L. Leahy, MD Associate Editor: Journal of the Endocrine Society Editorial Board: Journal of Biological Chemistry

Joel J. Schnure, MD Editorial Board: Coronary Artery Disease

Study Sections and Federal Advisory Boards

Dhananjay (Jay) Gupta, PhD Grant Review Panel, Diabetes UK

Thomas L. Jetton, PhD Federal review boards: EMNR-Study Section (SBIR and STTR), ad hoc reviewer NIDDK/NIH, ad hoc reviewer NIH (S10 SIG/SIFAR), ad hoc reviewer

John (Jack) L. Leahy, MD Hillblom Foundation, Scientific Advisory Board

Major Faculty Awards

None

Grants and Research

Dhananjay (Jay) Gupta, PhD Department of Medicine (UVM) IGP Research Award Vitamin D Signaling and Bioavailability in Pre-Clinical Models of Type 2 Diabetes (1/15/2020-1/15/2021) Role: Principal Investigator

Jennifer J. Kelly, DO, FACE Shire/Takeda PARADIGHM (Physicians Advancing Disease Knowledge in Hypoparathyroidism): A Registry for Patients With Chronic Hypoparathyroidism (2018-present) Role: Site Principal Investigator

Repository of Dual-Energy X-Ray Absorptiometry (DXA) Scans for Image Manipulation and Enhancement (2019- present) Role: Site Principal Investigator

Osteoporosis Center DXA Data Repository (2019-present) Role: Site Principal Investigator

Publications

Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB. American Association of Clinical Endocrinologists/Amer- ican College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Os- teoporosis – 2020 Update Executive Summary. Endocr Pract. 26(5):564-570, 2020.

Gilbert MP. Screening for Diabetic Retinopathy. Healio Educational Lab Case Series. https://cme.healio.com/endocrinology/education-lab/ace-the-case/2019/03_march/ace-the-case-patient-with-15-year-history-of-type-2-diabetes-mellitus/cme-information. Available August 15, 2019 through August 14, 2020.

Gilbert MP. Ace the Case: A 55-Year-Old, Postmenopausal Woman with an Elevated Calcium Level. https://cme.healio.com/endocrinology/education-lab/ace-the-case/2019/01_january/a-55-year-old-postmenopausal-woman-with-an-elevated-calcium-level/cme-information. Available September 16, 2019 through Septem- ber 15, 2020.

Gilbert MP. Ace the Case: Patient with a 20-Year History of Type 2 Diabetes Mellitus and Concern Regarding the Risk of Coronary Heart Disease. https://cme.healio.com/endocrinology/education-lab/ace-the-case/2019/03_march/patient-with-a-20-year-history-of-type-2-diabetes-mellitus/cme-information. Available October 15, 2019 through Oc- tober 14, 2020.

Gilbert MP. Ace the Case: A Patient with New-Onset Primary Hypothyroidism. Healio Educational Lab Case Series. https://cme.healio.com/endocrinology/ace-the-case/20190601/ace-the-case-a-patient-with-new-onset-primary- hypothyroidism/overview. Available November 15, 2019 through November 14, 2020.

Gilbert MP, Pratley RE. GLP-1 analogs and DPP-4 inhibitors in Type 2 diabetes therapy: Review of head-to-head clinical trials. Front Endocrinol (Lausanne). 2020 Apr 3;11:178.

Kelly JJ. Bone turnover markers in osteoporosis—letter to the JAMA editor in response to “Bauer DC. Clinical use of bone turnover markers. JAMA. 2019;322(6):569-570.” JAMA. 2019;322(23):2344.

Kelly JJ and Garapati SS. Combination therapies in the treatment of osteoporosis. Curr Opin Endocrinol Diabetes Obes. 26(6):292-295, 2019.

Leahy JL, Aleppo G, Fonseca VA, Garg SK, Hirsch IB, McCall AL, McGill JB, Polonsky WH. Optimizing Postprandial Glucose Management in Adults with Insulin-Requiring Diabetes: Report and Recommendations. J Endocr Soc. 2019 Oct 7;3(10):1942-1957.

Pratley RE, Emerson SS, Franek E, Gilbert MP, Marso SP, McGuire DK, Pieber TR, Zinman B, Hansen CT, Hansen MV, Mark T, Moses AC, Buse JB, on behalf of the DEVOTE Study Group. Cardiovascular safety and severe hypoglycaemia benefit of insulin degludec versus insulin glargine U100 in patients with type 2 diabetes aged 65 years or older: results from DEVOTE (DEVOTE 7). Diabetes Obes Metab. 2019;21:1625-1633.

Shahady E, Leahy JL. Sodium-Glucose Cotransporter 2 Inhibitor Protection Against Adverse Cardiovascular and Re- nal Outcomes in Patients with Type 2 Diabetes. Clin Diabetes. 2019 Jul;37(3):211-220.

Sheahan KH, Wahlberg EA, Gilbert MP. An overview of GLP-1 agonists and recent cardiovascular outcomes trials. Postgrad Med J. 2020 Mar; 96(1133):156-161.

Sheahan KH, Huffman GC, DeWitt JC, Gilbert MP. Metastatic lung cancer presenting as monocular blindness and panhypopituitarism secondary to a pituitary metastasis. Am J Case Rep 2020 Apr; 21:e920948 Doi: 10.12659/AJCR.920948.

Tharp WG, Gupta D, Sideleva O, Deacon CF, Holst JJ, Elahi D, Pratley RE. Effects of Pioglitazone on Glucose De- pendent Insulinotropic Polypeptide Mediated Insulin Secretion and Adipocyte Receptor Expression in Patients with Type 2 Diabetes. Diabetes. 2020 Feb;69(2):146-157.

Unger AL, Eckstrom K, Jetton TL, Kraft J. Colonic bacterial composition is sex-specific in aged CD-1 mice fed diets varying in fat quality. PLoS One. 2019(Dec 18);14(12): e0226635. doi: 10.1371/journal.pone.

Abstracts

Gilbert MP, DeVoe SG, Nevares A, Teneback CC. Improving Health Care Transitions for Young Adults at the Univer- sity of Vermont Medical Center. Poster presented at University of Vermont Medical Center Department of Medi- cine Scholarly Quality Improvement Poster Session; May 8, 2020; Virtual Presentation.

Sheahan K, Atherly A, Dayman CE, Schnure JJ. The Impact of Rapid Inpatient Endocrinology Consultations on Hos- pital Outcomes. American Diabetes Association 80th Scientific Session, Virtual Poster Session, Chicago, IL, June 12- 16. Diabetes 2020;69 Supplement (1):143-LB.

Sheahan K, Rankins C, Nathan MH, Kelly J. A Case of Isolated Elevated Free Triiodothyronine; poster presented at the American Association of Clinical Endocrinologists (AACE) 2020 Annual Scientific and Clinical Congress. Endocr Pract. 2020 May; 26(Suppl 4):281.

Sheahan K, Tompkins B, Kennedy AG, Repp AB, Gilbert MP. Impact of a Nursing Strike on Glycemic Control of Hos- pitalized Patients with Diabetes. American Diabetes Association 80th Scientific Session, Virtual Poster Session, Chi- cago, IL, June 12-16. Diabetes 2020;69 Supplement (1):1201-P.

Vennard-Barrett K, Kennedy AG, Repp AB, Tompkins B, Gilbert MP. Predictors and Consequences of Inappropriate Thyroid Ultrasound. Poster #456. 89th Annual Meeting of the American Thyroid Association, Chicago IL, October 30-November 3, 2019.

Presentations

Kaitlyn Barrett, DO “Post-Transplant Diabetes Mellitus” presented at Transplant Surgery monthly meeting at UVMMC on January 30, 2020.

“Diabetes Updates and Management for the Anesthesiologist” presented at Anesthesia Grand Rounds at UVMMC on May 21, 2020.

Matthew P. Gilbert, DO, MPH “Diabetes Management: Beyond Glycaemic Control” presented at the Global Diabetes Summit held in Frankfurt, Germany, October 4-5, 2019.

Jennifer J. Kelly, DO, FACE Course Director for “Osteoporosis Update for Primary Care” and speaker for “What’s New in Osteoporosis 2019,” presented September 27, 2019 at the UVM Davis Center.

“Boning Up on Bone Health” at the 25th annual Vermont 50+ Expo held February 15, 2020 at the University Mall in South Burlington.

John (Jack) L. Leahy, MD Debate participant for “Management of Type 2 Diabetes – Glucose vs. Obesity-centered Approach” arguing in favor of a glucocentric approach to treatment; held at Obesity Week 2019, the annual meeting of the Obesity Society, November 3-7, 2019 in Las Vegas.

Joel J. Schnure, MD Course Director for "Diabetes 2019: Updates on Management and Treatment," the 2nd annual Diabetes for Pri- mary Care Conference; attendees were primary care providers and clinicians from Vermont, New Hampshire, Maine, and upstate New York. November 8, 2019; Burlington, Vermont.

Annual Report July 1, 2019-June 30, 2020

Division of Gastroenterology and Hepatology

Richard Zubarik, MD, Section Chief http://www.med.uvm.edu/medicine/gastro/home The Gastroenterology and Hepatology Division at the University of Vermont College of Medicine/University of Ver- mont Medical Center has seven Gastroenterologists, one Advanced Practice Provider, four GI Fellows, and one Ph.D. 2019-20 has been a tough year for the gastroenterology division, the medical center, and the health care system in general. During the COVID pandemic the cohesion, compassion, comradery, ingenuity and grit of the UVMMC gastroenterology division has never been so evident and needed. These traits were evident in our care of patients, our role as educators, and in the research, we conducted.

We have continued to provide exceptional gastrointestinal care to our community through this period. In order to protect our patients and health care workers from illness we abruptly limited endoscopy to urgent procedures in March and then thoughtfully started ramping back up this summer to a point now in late July that we are back up to pre-COVID volumes. During this period, we rapidly implemented telehealth visits. We did these visits from home, from our office, from endoscopy, and from clinic. Because we adopted telehealth so readily, we were able to seamlessly provide state-of –the- art gastrointestinal care to our community, and even reduce our long pre-COVID wait times. During the COVID era, we have also worked aggressively to improve our endoscopy triage and scheduling process in order to provide efficient and timely endoscopic care to our patients. We have positioned ourselves to significantly reduce our endoscopic backlog in the future. Education of Fellows and Residents remains strong. Dr. Ferrentino continues to be our Fellowship Director. Dr. Reddy has taken on the role of Assistant Fellowship Director. Dr. Ganguly, who was promoted to full professor, also became a member of the teaching academy.

Education continues to be a priority for all members of our division. The challenges of maintaining social distancing resulted in us conducting conferences this year using teleconferencing. Although teleconferencing has limitations, it did allow us to stay connected and include physicians in our conferences that would otherwise have been difficult to include. Likely, this platform will be used in the future as we develop into a Network Department and try to reach learners at affiliated hospitals. During this period we were able to continue our regular educational conferences using teleconferencing, as well as adding liver rounds and gastroenterology morning report conferences to enhance the educational experience of our fellows and residents.

Research efforts were shut down during the first few months of the COVID pandemic. The unit remained productive despite this barrier. Dr. Lidofsky received a grant from the UVMHN to study the treatment of hepatitis C. Our division published articles on volumetric laser endomicroscopy for Barrett’s esophagus, diet and treatment in inflammatory bowel disease, risk factors for stent-associated cholangitis, intestinal serotonin and colitis, enteric neuroplasticity in inflammatory disease, and screening for hepatocellular cancer. We are currently conducting research in Hepatitis C, non-alcoholic steatohepatitis, treatment of IBD, pancreatic cancer, helicobacter pylori testing in peptic ulcer disease, novel technologies for esophageal dilation, and colonic neoplasia.

In summary, the Gastroenterology and Hepatology Division at the University of Vermont remains strong. The un- precedented challenges of this time have strained our system like no other. Through this time, it is clear that the greatest strength we have is our human capital. Our unit has always been about cohesion, collegiality, providing state-of-the-art compassionate care to patients in need, educating the future wave of health care providers, and having scientific inquisitiveness. These are the characteristics that are supporting us through this difficult time, and because of our collective talents, the Gastroenterology Unit remains strong. I am very proud to be part of this Divi- sion.

Richard Zubarik, MD

Nicholas Ferrentino, MD Associate Professor of Medicine Director, GI Fellowship Program . Chronic Viral Hepatitis . Management of Cirrhosis . General Gastroenterology and General Hepatology . Therapeutic Endoscopy

Joseph Frasca, MD Assistant Professor of Medicine Director of Inflammatory Bowel Disease . Inflammatory Bowel Disease . Crohn’s Disease . Ulcerative & Microscopic Colitis . Celiac Disease . Biliary Tract Disorders

Eric Ganguly, MD Professor of Medicine Director of Endoscopy . GI Oncology . Endoscopic Ultrasound and GI Malignancies . Barrett’s Esophagus and Radiofrequency Ablation for Barrett’s Esophagus . Therapeutic Endoscopy . GERD . Inflammatory Bowel Disease

Gordon Jensen, MD, Ph.D. Professor of Medicine and Nutrition Senior Associate Dean of Research  Nutrition assessment and therapy in chronic illness  Short bowel syndrome

Steven Lidofsky, MD, Ph.D. Professor of Medicine and Pharmacology Director, Hepatology Section Co-Director, Gastrointestinal Research Director, MD-Ph.D. Program . Cirrhosis . Hepatocellular Carcinoma . Hepatitis C . Nonalcoholic Fatty Liver Disease

Gary Mawe, Ph.D. Professor of Neurological Sciences; Adjunct Professor of Medicine and of Pharmacology . Neural Regulation of the Digestive Tract (understanding changes in enteric neural circuits that contribute to altered gut function in inflammatory bowel disease and irritable bowel syndrome)

Sheela Reddy, MD Assistant Professor of Medicine . Alcohol Related Liver Disease . Viral Hepatitis . Nonalcoholic Fatty Liver Disease . Autoimmune Liver Diseases . Role of Liver Transplantation in Patients with End Stage Liver Disease

Doris Strader, MD Professor of Medicine . Viral Hepatitis . Hepatitis C . Nonalcoholic Fatty Liver Disease . Eosinophilic Esophagitis . Cirrhosis . General Hepatology and General Gastroenterology

Richard Zubarik, MD Professor of Medicine Director of Gastroenterology & Hepatology Division . GI Oncology . Pancreatic Disorders . Dysphagia . Inflammatory Bowel Disease . Therapeutic Endoscopy and EUS . Endoscopic Ultrasound

Maia Stamieszkin, NP Nurse Practitioner  IBS  FODA Map

Sonja Dawsey, MD GI Fellow

Brendan Everett, MD GI Fellow

Abubakar Ibrahim, MD GI Fellow

Jason Heffley, MD GI Fellow

Leadership in Professional Studies: Steven Lidofsky, MD, Ph.D. . AASLD Leadership . Public and Clinical Policy Committee . Abstract review hepatobiliary neoplasia for Liver Meeting and DDW . Oral Session Moderator Digestive Disease Week 2019

Gary Mawe, Ph.D. . Strategic Planning Committee, American Neurogastroenterology and Motility Society, 2015-present . Fundamentals of Neurogastroenterology - Basic Science Committee, The Rome Foundation. The purpose of this committee is to develop a summary of the research and literature to date related to functional gastrointestinal disorders, and then offer guidelines or recommendations to help advance future research. 2012-present

Editorships and Editorial Boards: Steven Lidofsky, MD, Ph.D. . Ad hoc reviewer for American Journal of Gastroenterology . Ad hoc reviewer for Clinical Therapeutics . Ad hoc reviewer for Hepatology

Gary Mawe, Ph.D. . Editorial Board: Frontiers in Autonomic Neuroscience, 2010-present . Editorial Board: Frontiers in Gastrointestinal Sciences, 2011-present . Editorial Board: Journal of Visualized Experiments, (JoVE), 2011-present

Doris Strader, M.D. . Reviewer, American Journal of Gastroenterology, Clinical Gastroenterology & Hepatology, 2009-Present . Reviewer, Digestive Diseases and Sciences 2010- present . Reviewer, AASLD publication, Hepatology Journal 2010-present

Richard Zubarik, M.D. . Editorial Board Member, World Journal of Gastroenterology 2012-present . Reviewer, Gastrointestinal Endoscopy 2004-present . Reviewer, Evidence-Based Gastroenterology 2001-present . Reviewer, Journal of Gastroenterology 2006-present . Reviewer, Archives of Internal Medicine 2010-present . Reviewer, Digestive Diseases and Sciences 2010- present . Reviewer, International Journal of Inflammation 2012-present . Reviewer, American Society for Gastrointestinal Endoscopy Publications Committee . Reviewer, Journal of Endocrinological Investigation, 2015-Present

Study Sections and Federal Advisory Boards: Steven Lidofsky, MD, Ph.D. . Vermont Department of Health Steering Committee for Viral Hepatitis . Appointed to Editorial Board, World Journal of Hepatology

Doris Strader, MD . Director of Data Safety Monitoring Board for NIH Hepatitis B Research Network, 2011-Present

Grants – list all active by faculty member, PI Steven Lidofsky, MD, Ph.D. . UVMHN Medical Group (Steven Lidofsky, Co-PI with Andrew Hale) Empowering hepatitis C management in primary care by electronic linkage to specialty guidance (January 2020 - December 2021)

Pharmaceutical Sponsored Research Steven Lidofsky, MD, Ph.D.  Intercept: A phase 3 randomized long-term placebo-controlled multicenter study evaluating the safety and efficacy of obeticholic acid in subjects with nonalcoholic steatohepatitis (NASH)  Gilead: A phase 3 multi-center double-blind randomized placebo-controlled trial of selonsertib in subjects with nonalcoholic steatohepatitis and advanced hepatic fibrosis  Target Pharmasolutions: A multi-center study of the management and outcomes of subjects with nonalcoholic fatty liver disease  Conatus: A phase 2 multi-center double-blind randomized placebo-controlled trial of emricasan in subjects with NASH cirrhosis and severe portal hypertension  Intercept: A phase 2 randomized, long-term placebo-controlled multicenter study evaluating the safety and efficacy of obeticholic acid in subjects with cirrhosis due to NASH  Celgene: A phase 2 multicenter study of the JNK inhibitor CC-90001 for non-alcoholic steatohepatitis (NASH) with advanced hepatic fibrosis or cirrhosis.  Gilead (Steven Lidofsky, Site PI) A phase 3 randomized controlled trial for the FXR agonist cilofexor for noncirrhotic primary sclerosing cholangitis (2020-2022)

Joseph Frasca, MD . Sub-Investigator. A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Efficacy of GS-9674 in Non-Cirrhotic Subjects with Primary Sclerosing Cholangitis. Proto- col # GS-US-428-4194. Gilead Sciences, Inc. . Site Principal Investigator. A Study of the Efficacy and Safety of Risankizumab in Participants with Moder- ately to Severely Active Crohn’s Disease. AbbVie, Inc. Pending

Other Research Richard Zubarik, MD

. Pancreatic Cancer Screening Employing CA 19-9 and Targeted Endoscopic Ultrasound (EUS) in a High Risk Population . A Pilot Study to Determine if the Endoscopic Dilation Monitor can Create Real-Time Pressure/Volume and Pressure/Time Curves during Endoscopic Balloon Dilation of Esophageal Strictures, and if these Curves Vary According to Stricture Etiology. . Choledocholithiasis After Normal Diagnostic Cholaniogram or Endoscopic Clearance of Bile Duct . The Incidence and Risk Factors for Development of Ascending Cholangitis Following Common Bile Duct Stent Placement

Publications – peer reviewed, chapters, etc. (not abstracts)

Maarten Struyvenberg 1 , Allon Kahn 2 , David Fleischer 3 , Anne-Fre Swager 1 , Brett Bouma 4 , Eric Ganguly 5 , Vani Konda 6 , Charles Lightdale 7 , Douglas Pleskow 8 , Amrita Sethi 9 , Michael Smith 10 , Arvind Trindade 11 , Michael Wallace 12 , Kenneth Wang 13 , Herbert Wolfsen 14 , G Tearney 15 , Wouter Curvers 16 , Cadman Leggett 17 , Jacques Bergman 1 . Expert Assessment on Volumetric Laser Endomicroscopy Full-Scans in Barrett's Esophagus Patients With or Without High-Grade Dysplasia or Early Cancer Endoscopy 2020 Jun 8. doi: 10.1055/a-1194-0397. Online ahead of print. PMID: 32515006

M R Struyvenberg 1 , A J de Groof 1 , A Kahn 2 , B L A M Weusten 3 , D E Fleischer 2 , E K Ganguly 4 , V J A Konda 5 , C J Lightdale 6 , D K Pleskow 7 , A Sethi 8 , M S Smith 9 , A J Trindade 10 , M B Wallace 11 , H C Wolfsen 11 , G J Tearney 12 , S L Meijer 13 , C L Leggett 14 , J J G H M Bergman 1 , W L Curvers 15. Multicenter Study on the Diagnostic Performance of Multiframe Volumetric Laser Endomicroscopy Targets for Barrett's Esoph- agus Neoplasia With Histopathology Correlation. Dis Esophagus. 2020 Jul 1;doaa062. doi: 10.1093/dote/doaa062. Online ahead of print. PMID: 32607539

Joseph D Frasca, Adam S Cheifetz. Diet and inflammatory Bowel Disease: What is the role? Practical Gastroenterol- ogy. June 2019; 84-93.

Joseph D Frasca 1 , Adam S Cheifetz 2 . Editorial: real-world short-term effectiveness of ustekinumab in 305 patients with Crohn's disease-results from the ENEIDA registry Aliment Pharmacol Ther. 2019 Sep;50(5):599-600. doi: 10.1111/apt.15405. PMID: 31414548

Joseph D Frasca 1 , Adam S Cheifetz 2 . . Editorial: The Cost and Benefit of Anti-TNF Therapy From a Population Per- spective - For What It’s Worth. Ann Transl Med. 2019 Dec:7(Suppl 8), S388. PMID: 32016106.

Lidofsky SD. Screening for Hepatocellular Carcinoma in Cirrhosis: Challenges and Unresolved Issues. Gastroenterol- ogy. 2019 Mar;156(4):1217-1218. PMID: 29707105

Spear, E.T. and G.M. Mawe. Enteric neuroplasticity and dysmotility in inflammatory disease: key players and possible therapeutic targets. American Journal of Physiology. 2019 Dec 1;317:G853-G861. PMID: 31604034

Lavoie, B., J.A. Roberts, M.M. Haag, S.N. Spohn, K.G. Margolis, K.A. Sharkey, J.B. Lian and G.M. Mawe. Gut-derived serotonin contributes to bone deficits in colitis. Pharmacological Research. 2019 Feb;140:75-84 PMID: 30030171

Sprouse-Blum, AS, B Lavoie, M Haag, SM Mawe, EA Tolner, AMJM van den Maagdenberg, S-P Chen, K Eikermann- Haerter, L Ptacek, GM Mawe, and RE Shapiro. No gastrointestinal dysmotility in transgenic mouse models of mi- graine. Headache. 2020 Feb;60:396-404 PMID: 31876298

Everett BT, Naud S, Zubarik RS. Risk Factors For The Development Of Stent-Associated Cholangitis Fol- lowing Endoscopic Biliary Stent Placement.. Dig Dis Sci. 2019 Feb 20. doi: 10.1007/s10620-019-05533-6. [Epub ahead of print] PMID: 30788687

General Internal Medicine Division Jennifer Gilwee, MD, Division Chief http://www.med.uvm.edu/medicine/generalinternalmedicinegeriatrics/home

The Division of General Internal Medicine specializes in diagnosing, treating, and preventing medical problems in adolescents, adults, and the elderly. Our general internal medicine physicians work with their teams in the outpatient clinics to care for a large proportion of patients in our area. When the COVID-19 pandemic struck our area early in 2020 we had to act quickly to maintain connections to our patients through telemedicine. This allowed our patients to still get the care they needed in their homes without exposing them to potential risk of contracting the virus.

Our faculty physicians teach the principles of general internal medicine to medical students, resident physicians, professional colleagues, and community members. We hold several leadership roles at the College of Medicine and are proud to serve an integral role in our vibrant academic medical center.

Service: Our clinical service includes approximately 42 physicians, nurse practitioners and physician assistants. We have four outpatient sites in Chittenden County. In April of 2020 our Essex providers moved into a brand new state of the art building. In the office setting, patients are seen for a variety of acute and chronic medical problems, preventive care, health maintenance and preoperative exams. Our group has been a national leader in developing innovative models for care delivery. All four outpatient sites have been consistently recognized as NCQA as level 3 Patient Centered Medical Homes. In the era of new payment structures for health care, we have been transitioning to more value-based care models from the traditional fee-for-service model. This year our general internal medicine faculty and providers will conduct approximately 70,000 patient encounters via in-person and virtual care (telemedicine and e-visits).

Our faculty and providers are extensively engaged in service at the state and national levels. A few examples include:

President of the New England Society of General Internal Medicine, Immediate Past Presi- dent of the Board of Directors of the Federation of State Medical Boards, member of the State Board Advisory Committee to the USMLE, member of the Vermont Commissioner of Health’s Task Force on Opioid Prescribing, USMLE Composite Committee member, Vermont Medicaid Drug Utilization Board members, OneCare Vermont Regional Clinician Repre- sentative, OneCare Population Health Committee Representative, Vermont Blueprint for Health Executive Committee, Councilor of the Vermont Chapter of the Alpha Omega Alpha Medical Honor Society

Education: Division faculty members play a pivotal role in teaching and directing courses for a broad audience of clinical learners in the outpatient and inpatient settings. Our educational programs cover a wide spectrum, from communication skills to clinical skills, and from pre-medical students to post-graduate continuing medical education.

At the UVM College of Medicine, our faculty member’s act as preceptors, instructors, and facilitators for courses at all levels of the Vermont Integrated Curriculum. Additionally, we serve as course directors for Convergence (Dr. Patricia King), Doctoring Skills (Dr. Alan Rubin) and Outpatient Medicine Clerkship (Dr. Roberta O’Brien). Adminis- trative leadership positions at the College of Medicine include Associate Dean for Clinical Education (Dr. Tania Bertsch), Associate Dean for Primary Care (Dr. Charles Maclean).

We also play key roles in the clinical education of the Internal Medicine residents. Our Adult Primary Care Burling- ton site houses the Internal Medicine Resident Clinic – where the Internal Medicine residents practice under the supervision of our preceptors and firm leaders in a busy clinic environment. Dr. Richard Pinckney and Dr. Halle So- bel lead the curricular coordination for the Resident Clinic.

Our educational endeavors extend to graduate students in analysis of clinical research, nurse practitioners in palliative care fellowship programs, and nurse practitioner students in clinical compassion. We educate our colleagues locally, regionally and nationally in a variety of venues. An example of this is the Vermont Academic Detailing Pro- gram which delivers educational outreach to Vermont’s primary care providers.

Research Many of our clinical faculty conduct research via the General Internal Medicine Research unit and provide mentorship, resources, and a scholarly community that supports faculty from many departments in their investigations. We have a diversity of scholarly interests among our faculty including the impact of primary care redesign and mental health integration, narcotic prescribing practices in the outpatient setting, innovative models in medical education, improving transitions of care between health care settings, the use of portable technology in hypertension control, the role of inflammation in chronic disease management and disparities of health in rural populations.

Faculty

Adult Primary Care - Burlington

Claudia Berger, MD (Site Clinical Leader) Assistant Professor of Medicine

Amy Dinitz, MD Assistant Professor of Medicine

Mia Hockett, MD, MPH Assistant Professor of Medicine

Michael Latreille, MD Assistant Professor of Medicine

Benjamin Littenberg, MD (see Division of GIM-Research) Professor of Medicine Director, Division of General Internal Medicine - Research

Scott Luria, MD Associate Professor of Medicine (Emeritus)

John Miller, MD Assistant Professor of Medicine

Richard Pinckney, MD, MPH Associate Professor of Medicine Co-Director, Internal Medicine Resident Clinic

Alan Rubin, MD (see Division of GIM-Research) Professor of Medicine

Halle Sobel, MD Associate Professor of Medicine Co-Director, Internal Medicine Resident Clinic

Emily Hadley Strout, MD Assistant Professor Medicine

Adult Primary Care - Essex

Karen Abernathy, MD Assistant Professor of Medicine

Tania Bertsch, MD Associate Professor of Medicine Associate Dean for Clinical Education

Gary Gilmond, MD Assistant Professor of Medicine

Diane Haddock, MD (Site Clinical Leader) Assistant Professor of Medicine

Patricia King, MD, PhD Professor of Medicine Convergence Course Director, Vermont Integrated Curriculum, UVM College of Medicine

Charles MacLean, MD (see Division of GIM-Research) Professor of Medicine Associate Dean for Primary Care  Health services research and epidemiology

Roberta O’Brien, MD Associate Professor of Medicine Director, Internal Medicine Clerkship

Adult Primary Care – South Burlington

Dennis Beatty, MD Associate Professor of Medicine

Jennifer Gilwee, MD Associate Professor of Medicine

Division Chief, General Internal Medicine

Jason Gramling, MD Assistant Professor of Medicine

Emily Greenberger, MD Assistant Professor of Medicine

Diane Hakey, MD Assistant Professor of Medicine

Sara Roberts, MD Assistant Professor of Medicine

Marie Sandoval, MD (Site Clinical Leader) Associate Professor of Medicine

Susan Weinstein, DO Assistant Professor of Medicine

David Ziegelman, MD Assistant Professor of Medicine

Adult Primary Care - Williston

Anne Breña, MD Assistant Professor of Medicine

Lucy Miller, MD (Site Clinical Leader) Assistant Professor of Medicine

Dennis Plante, MD Associate Professor of Medicine (Emeritus)

Jonathan Benjamin Wilfong, MD Assistant Professor of Medicine

Other Division Members:

Timothy Plante, MD, MHS Assistant Professor of Medicine

Adam Atherly, Ph.D. Director of the Health Services Research Center Professor of Medicine

Nurse Practitioners, Physician Assistants, and Mental Health Specialists:

Adult Primary Care - Burlington Tracey Niquette, NP Laura Weiland, PA

Adult Primary Care - Essex Sarah Bushweller, PA Alison Hall, PA David Spence, PA

Adult Primary Care - South Burlington Diane Bell, NP Rachel Brodie, PA Sarah McLaughlin, NP Desiree Price, NP

Adult Primary Care - Williston Genevieve Flanders, PA Meagan Goodwin, NP

Leadership in Professional Societies:

Patricia King, MD, PhD  Chair, Composite Committee of United States Medical Licensing Exam

Halle Sobel, MD  President, New England Chapter of Society of General Internal Medicine

Sarah Bushweller, PA  Board of Directors for the Physician Assistant Academy of Vermont  Vermont representative to the House of Delegates, American Academy of Physician Assistants

Dennis Beatty, MD  AAMC Council of Faculty and Academic Societies, Senior Representative from Larner College of Medicine

Editorships and Editorial Boards:

Halle Sobel, MD  Reviewer: Annals of Internal Medicine, AAIM, SGIM, JGIM, AJM

Study Sections and Federal Advisory Boards:

Patricia King, MD, PhD  Federation of State Medical Boards Advisory Council to the United States Medical Licensing Examination  National Board of Medical Examiners Standards Setting Committee for USMLE Step 1

Major Faculty Awards:

 Dean’s Faculty Award for Professionalism- Jennifer Gilwee, MD  Curriculum Innovation Award from the Class of 2022- Patricia King, MD, PhD  Bloomfield Early Career Professorship in Cardiovascular Research- Timothy Plante, MD, MHS

Grants

 Halle Sobel, MD SAMSHA grant Grant Number: 1 H79 TI082571-01 Project Title: Increasing the Pipeline of MAT Prescribers: DATA Waiver Training for All Vermont Medical Students at The Larner College of Medicine

 Michael Latreille, MD UVM Medical Center Foundation Grant: A Learning Garden to Cultivate Patient and Community Health. Total funds: $68, 279

 Benjamin Littenberg, MD, Richard Pinckney, MD (co-investigators) PCS-1409-24372. Integrating Behavioral Health and Primary Care for Co-Morbid Behavioral and Medical Problems. Total Direct Costs: $18, 523, 145.

 Emily Greenberger, MD UHC Fund Grant: Incorporating Ultra-brief Psychotherapy into a Primary Care Visit

 Sara Roberts, MD UHC Fund Grant: Effect of Patient Education Regarding Strength Training

Publications – peer reviewed, chapters, etc. (not abstracts)

Smith L, Atherly A, Campbell J, Flattery N, Coronel S, Krantz M. Cost-effectiveness of a statewide public health intervention to reduce cardiovascular disease risk. BMC Public Health. 2019 Sep 6;19(1); 1234.

Lou Y, Atherly A, Johnson T, Anderson M, Valdez C, Sabalot S. The impact of care management for high-risk pediatric asthmatics on healthcare utilization. J Asthma. 2019Sep 9:1-8.

Plante T, Gleason K, Miller H, Charleston J, McArthur K, Himmelfarb C, Lazo M, Ford D, Miller III E, Appel L, Juraschek S. Recruitment of trial participants through electronic medical record patients portal messaging: A pilot study. Clinical Trials I-9, 2019.

Sobel HG, Goedde M, Maruti S, Hadley-Strout E, Wahlberg E, Kennedy AG. Primary Care Resi- dents Delivering Care: Integration of Office-Based Opioid Treatment into an Internal Medicine Residency Curriculum. Acad Psychiatry. 2019 Oct: 43 (5): 499-502. van Eeghen C, Kennedy AG, Pasanen M, MacLean CD. Developing a New Approach to Improve Opioid Prescribing Practices in Primary Care: Evolution of a Quality Improvement Toolkit. JABFM 2019, in press

Van Eeghen C, Edwards M, Libman BS, MacLean CD, Kennedy AG. Order from Chaos: An Initia- tive to Improve Opioid Prescribing in Rheumatology Using Lean A3. ACR Open Rheumatol. 2019 Sep 4;1(9):546-551 doi: 10.1002/acr2.11078. eCollection 2019 Nov. PMID: 31777838 [Pub- Med] Free PMC Article

Van Helmond N, Martin SS, Plante TB. Is cuffless blood pressure measurement already here? Journal of Hypertension:38(4):744-775. PMID: 32132434

Plante TB, Koh I, Wilcock AD. Concordance of rural identity and ZIP code-linked Rural-Urban Commuting Area (RUCA) code. The Journal of Rural Health. 2020:36:143-144. PMID: 32216155

Bonnell LN, Littenberg B, Wshah SR, Rose GL. A machine learning approach to identification of unhealthy drinking. J Am Board Fam Med 2020;33:397–406.

Geriatric Medicine Michael LaMantia, MD, Division Chief https://www.med.uvm.edu/medicine/geriatrics

The Division of Geriatric Medicine specializes in providing world-class, personalized medical care to older adults in a variety of settings, including nursing homes, rehabilitation facilities, clinics, and patient homes. We strive to get to know our patients as individuals and recognize the important role that their family, friends, caregivers, and community play in their identity and in their care. We are excited to work with our colleagues across Vermont and Northern New York State to ensure that our area remains one of the best places in the country to age in place.

Our faculty physicians teach geriatric medicine to medical students, resident physicians, professional colleagues, and community members. We hold numerous leadership roles at the College of Medicine and are proud to serve an integral role in our vibrant academic medical center.

Service: Our 8 physicians and 1 nurse practitioner care for many geriatric patients in Chittenden County, attending to elderly patients living independently, in assisted living, in local nursing homes, and at hospice. Our Geriatric Medicine Division does consultations for the care of older adults through our Adult Primary Care Williston location. Education: Our geriatricians play a key role in teaching medical students, residents, undergraduates, graduate students, and providers across the region in issues affecting older adults. In addition, we speak widely on topics in aging in public venues across the region; we are interviewed frequently by newspaper and television reporters on the subject; and we provide evidence-based guidance to partners in community organizations as well as local and state govern- ment.

We teach the following groups of learners at the University of Vermont and University of Vermont Medical Center:

Undergraduate Students: Our faculty frequently teach in courses at the undergraduate level, often in courses led by our colleagues in the University of Vermont Center on Aging. In addition, our partners at the Center on Aging frequently work with us to find mentor and volunteer experiences for undergraduates interested in experiences in aging.

Medical Students: We teach medical students in the Doctoring in Vermont Course, the second-year Human Devel- opment and Reproductive Health Course, in clerkships, and in special electives.

Medical Residents: All internal medicine residents complete a required rotation in geriatric medicine where they evaluate patients in a variety of care settings under the supervision of our faculty.

Graduate Students: Our faculty have offered seminar courses in the Graduate College on topics related to aging through the Clinical and Translational Sciences program.

Research Our faculty conduct research on a wide variety of topics affecting older adults in partnership with and with the support of the University of Vermont Center on Aging. Particular areas of focus include care of patients with cognitive impairment including delirium and dementia, care of older adults with chronic kidney disease, and care of older adults in the emergency department.

Faculty - Geriatric Medicine

Zail Berry, MD Associate Professor of Medicine Medical Director, The Arbors  Geriatric Medicine  Key Research Area: Optimizing care of elders in long-term care facilities

Amelia Gennari, MD Associate Professor of Medicine Associate Chief for Clinical Affairs  Geriatric Medicine

Elizabeth Rosy Hill, MD Assistant Professor of Medicine Medical Director of Green Mountain Nursing Facility  Geriatric Medicine

Michael LaMantia, MD Associate Professor of Medicine  Chief, Division of Geriatric Medicine  Holly and Bob Miller Chair of Memory and Aging

Isaura Menzies, MD Associate Professor of Medicine Associate Chief for Education Medical Director of Elderwood Skilled Nursing Facility  Geriatric Medicine

Alexandra Messerli, MD Assistant Professor of Medicine  Geriatric Medicine

Susanna Thach, MD Assistant Professor of Medicine  Geriatric Medicine

Lynn Wilkinson, MD Assistant Professor of Medicine Associate Chief for Quality Improvement Medical Director, Birchwood Terrace Health Care  Geriatric Medicine

Nurse Practitioners, Physician Assistants, and Mental Health Specialists:

Birchwood Nursing Center (Skilled Nursing Facility) Amber Snow, NP

Editorships and Editorial Boards:

Michael LaMantia, MD  Deputy Editor, Journal of General Internal Medicine

Grants

LaMantia, Michael, MD: K23 Award, Delirium Evaluation in the Emergency Department

LaMantia, Michael, MD: NNECTR Pilot Grant- Feasibility of a Community Health Worker Intervention for Functional Decline in Rural Older Adults

Publications – peer reviewed, chapters, etc. (not abstracts)

1. Kennedy MA, Pepin R, Stevens CJ, Bartels SJ, Batsis JA, Beyea A, Bruce ML, Eckhaus JM, Korsen N, Pidgeon DM, Powell KE, Reynolds CF, LaMantia MA. Mind, Mood, Mobility: Supporting Independence Among Rural Older Adults at Risk for Functional Decline. American Journal of Health Promotion. 2020. 2. Cheung KL, LaMantia MA. Cognitive Impairment and Mortality in Patients Receiving He- modialysis: Implications and Future Research Avenues. American Journal of Kidney Dis- eases. 2019: 74(4). 435-437. 3. Kennedy M, Koehl J, Shenvi CL, Greenberg A, Zurek O, LaMantia M, Lo AX. The agitated older adult in the emergency department: a narrative review of common causes and management strategies. Jounral of the American College of Emergency Physicians Open. 2020. 4. Howerton MA, Suhrie EM, Gennari AS, Jones N, Ruby CM. Evaluation of Direct Oral An- ticoagulant Dosing and Monitoring in Two Geriatric Outpatient Clinics. Senior Care Phar- macist 2019 Mar 1;34(3):192-205.

Chris Holmes, MD, Interim Director http://www.uvm.edu/medicine/medicine/hemonc/

A. Executive Summary

The Division of Hematology and Oncology has had a successful clinical and academic year with a continued dedication to our tri-partide mission of teaching, research and high quality, patient centered care. The division has 17 faculty members located at the UVMMC campus with additional faculty members at CVMC (2), Porter Medical Center (1) and CVPH (1). Faculty in the division care for patients with oncologic and hematologic malignancies, benign hematology, as well as thrombotic and bleeding disorders. The clinical care enterprise is also comprised of 6 APPs, 2 genetic counselors and over 50 nurses and staff in the outpatient UVMMC clinic. In 2019-2020, the division provided over 18,000 outpatient visits, 2500 new patients visits in addition to ~ 10,500 infusion and 650 procedures. Inpatient services offered by the division include a hematology consult service, an oncology consult service and a heme-malignancy inpatient service. In addition to specialized hematology services and subspecialty oncologic care, the division also provides unique services to our patient population including:

 The Thrombosis & Hemostasis Program, (Dr. Cushman, Director)  Multidisciplinary Oncology Clinics (in collaboration with surgery & radonc)  The Apheresis Program, (Dr. Sprague, Director)  The VT Regional Hemophilia Treatment Center (federal designation, Dr. Holmes, PI)  The FACT accredited Autologous Stem Cell Transplant Program (Dr. Sprague, Director)  The High Risk Breast Program, a clinical research program, (Dr. Wood, PI)  Familial Cancer Genetics, (Drs. Wood and Greenblatt, PI’s with 2 cancer geneticists)  Oncology Rehabilitation, (Dr. Dittus, Medical Director)  Lymphedema Care and Expertise, (Dr. O’Brien, PI)  Prevention of Cancer Associated Thrombosis (VTEPACC, Dr. Holmes PI)

The division maintains an active fellowship program comprised of 6 fellows under the direction of Dr. Julian Sprague (Program Director) and Dr. Molly Barry (Associate Program Director). Specialized tracks in thrombosis & hemostasis, familial genetics and breast cancer are available to fellows and promote the academic careers of interested fellows. Fellows maintain an active clinical schedule and have engaged in research resulting in 5 national abstracts, 9 local meeting presentations and 5 publications with 4 under review in 2019. In addition to mentoring and teaching fellows, multiple faculty members serve as research and professional mentors to both medical students and internal medicine residents. Division highlights for the year in education include Dr. Sakshi Jasra participated in the Larner College of Medicine Teaching Academy and Dr. Molly Barry serves as a member of the ASCO eLearn Question Writing Group.

Research within the division focuses on epidemiologic and translational research as well as clinical trials. In the past year, faculty members have served as the site PI on 30 interventional clinical trials and have 6 ongoing investigator initiated studies with ~408 patient recruitments. Inves- tigators within the Division receive funding from clinical trials (national cooperative group and pharmaceutical trials), NIH NCI, NHLBI, AHA, and NINDS. The division faculty and fellows published 79 manuscripts in the last year and were involved in numerous local, national and international abstract presentations. Members of the division members also hold key leadership positions within the University of Vermont Cancer Center and including Dr. Holmes (appointed interim Co-Director of the UVM Cancer Center in January 2020; Dr. Wood (Associate Director of Cancer Control and Population Health Science); Dr. Ades (Medical Director of the Clinical Trial Office); Dr. Greenblatt (Mo- lecular Mechanisms of Malignancy Program Co-Leader) and Dr. Kaufman (Co-leader of the Host Factor and Tumor Progression Program). Dr. Cushman serves on the Board of Directors of the Cardiovascular Research Institute at the University of Vermont. Faculty

Jose Acostamadiedo, MD-Clinical Practice Physician Physician at CVPH Research and clinical interests: Lung Cancer and Melanoma

Steven Ades, MD, MSc – Associate Professor Leader, UVM Medical Upper Gastrointestinal Oncology Transdisciplinary Team Co-Leader, UVM Medical Center Genitourinary Oncology Transdisciplinary Team Medical Director, UVM Cancer Center Clinical Trials Office Member, University of Vermont Cancer Center Protocol Review and Monitoring Com- mittee Member, UVM Faculty Senate Financial & Physical Planning Committee Member, UVM Medical Center Hematology/Oncology Fellowship Program Evaluation Committee Member, UVM Medical Center Hematology/Oncology Fellowship Clinical Competency Committee Member, Hematology/Oncology Division Chief Search Committee Research and clinical interests: GI and GU cancers, supportive care and thrombosis in malignancy

Diego Adrianzen Herrera, MD-Assistant Professor Member, Protocol Review and Monitoring Committee, UVM Cancer Center Member, Search Committee, Benign Hematology Clinical Scholar Pathway Member, Grand Rounds Committee, Division of Hematology and Oncology Member, Hematology/Oncology Fellowship Applicant Review and Interview Committee Research and clinical interests: Clinical correlation and epidemiologic significance of clonal hematopoiesis, myelodysplastic syndrome and cardiovascular disease. Novel diagnostic, therapeutic or prognostic markers in acute myeloid leukemia. Developing and implementing a portfolio of clinical trials in malignant hematology at UVM

Shahid Ahmed, MD, MBBS-Assistant Professor

Member - University of Vermont Cancer Center Member - UVMMC Protocol Review and Monitoring Committee (PRMC) Member - UVM Health Network Covid-19 Hematology/Oncology Re-entry committee Member - UVMMC Hematology/Oncology Grand Rounds Committee Member - Genitourinary oncology Transdisciplinary team Member - Cutaneous oncology Transdisciplinary team Research and clinical interests: Clinical trials in genitourinary and cutaneous malignancies. T cell receptor repertoire analysis in malignancies

Maura Barry, MD-Assistant Professor Associate Program Director, Hematology/Oncology Fellowship Program Member, UVMMC Department of Medicine Faculty Development Committee, Member, UVM Medical Center Hematology/Oncology Fellowship Program Evaluation Committee Member, UVM Internal Medicine Residency Program Evaluation Committee Member, UVM Medical Center Hematology/Oncology Fellowship Clinical Competency Committee Member, Larner College of Medicine Committee on Fitness Member, Larner College of Medicine Teaching Academy Member, UVM Medical Center EPIC Advisory Council Member, UVM Medical Center EPIC Oncology Power Team EPIC Specialty Champion Member, Education and Professional Development Working Group, LCOM Gender Eq- uity Initiative Member, LCME Self-Study Task Force, Subcommittee 9 Research and clinical interests: Medical Education GI and head and neck cancers, supportive care, wellness.

Mary Cushman, MD, MSc – Professor, Medicine and Pathology Director, Thrombosis and Hemostasis Program Research and clinical interests: Etiology of cardiovascular diseases, stroke, cognitive impairment and other chronic diseases; racial disparities; venous thrombosis and post thrombotic syndrome, COVID-19

Kim Dittus, MD, PhD – Associate Professor Medical Director of Oncology Rehabilitation Director, Inpatient Hematology/Oncology Chair Clinical Committee, Program in Integrative Health Member, Cancer Control Committee, UVM Medical Center Research and Clinical interests: Breast Cancer, Cancer survivorship, diet/nutrition, exercise

Marc Greenblatt, MD – Professor Co-Chair, UVM Cancer Center Molecular Mechanisms of Malignancy Program Assistant Director, Hematology/Oncology Fellowship Program Research and clinical interests: Cancer genetics and gastrointestinal cancers

Chris Holmes, MD, PhD – Associate Professor Interim Division Chief, Hematology/Oncology Division Interim Co-Director, University of Vermont Cancer Center Director, Vermont Regional Hemophilia Treatment Center Assistant Director, Thrombosis and Hemostasis Program Research and clinical interests: Venous thrombosis, platelet function, coagulation and cancer

Sakshi Jasra, MD—Assistant Professor Co-chair, UVM Department of Hematology/Oncology Grand Rounds Committee Member, UVM Cancer Center Data Safety and Monitoring Board Member, UVM Department of Medicine Operations Committee Research and clinical interests: Exploring barriers to clinical trial enrollment in rural cancer patients, qualitative research methods and their applications in rural health and mechanisms and clinical relevance of clonal hematopoiesis

Peter Kaufman, MD – Professor Member, Vermont Cancer Center Data Safety and Monitoring Committee (DSMC) Director, Regional Clinical Trials, Vermont Cancer Center Program Co-Leader, Host Factors and Tumor Progression (HFTP) Vermont Cancer Cen- ter Member, Clinical Trials Executive Committee, Vermont Cancer Center Research and clinical interests: Breast cancer, translational research in breast cancer, clinical research and clinical trials in breast cancer

Farrah Khan, MD – Assistant Professor Member: UVMMC Department of Medicine Faculty Development Committee, Faculty Engagement Committee Member, UVMMC Department of Medicine Quality Assurance and Improvement Com- mittee Member, Data Safety and Monitoring Committee, UVM Cancer Center Member, Executive Board for the Pharmacy and Therapeutics Committee Research and clinical interests: Lung cancer, breast cancer, mesothelioma, sarcoma and supportive/palliative care

Saranya Kodali, MD—Clinical Practice Physician Physician at CVMC Member, Faculty Development Committee at UVMMC Research and clinical interests: Malignant Hematology

Patricia O’Brien, MD – Assistant Professor Clinical Scholar Director, Lymphedema Program Oncology Rehab-Steps to Wellness

Hibba tul Rehman, MD—Assistant Professor Member, Protocol Review and Monitoring Committee

Member, Clinical Competency Committee for Hem/Onc Fellowship Member, Program Evaluation Committee for Hem/Onc Fellowship Member, UVMMC Credentials Committee Research and clinical interests: Lung cancer, sarcoma, breast cancer and rare tumors

Julian Sprague, MD, PhD – Associate Professor Director, Hematology/Oncology Fellowship Program Director, Stem Cell Transplant Program, University of Vermont Medical Center Clinical Director, Apheresis Services Member, UVM Medical Center, Transfusion Committee Member, UVM Medical Center, Ethics Committee Research and clinical interests: Myeloma and neurotoxicity, hematologic malignancies

Eswar Tipirneni, MD—Clinical Practice Physician Physician at CVMC Research and clinical interests: Immunotherapy and lung cancer

Elvira Umyarova, MD—Assistant Professor Research and clinical interests: Malignant hematology, stem cell transplant, clinical trials

Paul Unger, MD, FACP—Associate Professor Site Leader, Community Oncology Porter Chair, UVMMC Credential Committee Research and clinical interests: Quality assessment for clinical oncology in community practice

Marie Wood, MD – Professor Director, Familial Cancer Program Assistant Director, Hematology/Oncology Division Associate Director, Cancer Control Co-leader, University of Vermont Cancer Center, Control & Populations Health Science Program Co-Chair, University of Vermont Faculty Senate Educational and Research Technologies Committee Research and clinical interests: Biomarkers of breast cancer risk, genetic testing in rural areas, breast cancer screening and prevention

Neil Zakai, MD, MSc – Associate Professor of Medicine and Pathology Member (Past Chair), UVM Cancer Center Data Safety and Monitoring Board Member, UVM Medical Center Pharmacy and Therapeutics Committee Member, UVM Medical Center Hematology/Oncology Fellowship Research Committee Member, UVM Medical Center Internal Medicine Residency Research Committee Chair, Medication Safety Subcommittee for the Pharmacy & Therapeutics Committee Research and clinical interests: Epidemiology and novel risk factors for venous thrombosis and cardiovascular disease. Epidemiology, causes, and consequences of anemia in

diverse populations. Venous thrombosis causes and prevention, post thrombotic syndrome.

Hematology/Oncology Fellows Kitty Victoria, MD –3rd year fellow Waqas Jehangir, MD –3rd year fellow Ximena JordanBruno, MD—2nd year fellow Sarah Gillett—2nd year fellow Kara Landry, MD—1st year fellow Mansour Gergi, MD—1st year fellow

NP’s and PA’s Jamie Kelly, PA Penny Gibson, PA Jordan Tolstoi, PA Anne Berkowitz, NP Janet Ely, NP Emily Parenteau, MSN, FNP

Graduate students, post-doctoral fellows, MD PHD students Juan Conde, PhD. Medical Student Research. Smoking, Biomarkers and Stroke Risk. Medical Student Research. Mentored by Mary Cushman Charles Nicoli. Medical Student Research. Mentored by Mary Cushman Debora Kamin Mukaz, PhD. Post-doctoral associate. Mechanisms of racial disparities in diabetes and hypertension incidence affecting African-Americans. American Heart As- sociation Travel Award, International Stroke Conference Pre-Conference Symposium, HEADS UP: Health Equity and Actionable Disparities in Stroke, 2020. Mentored by Mary Cushman Samuel Short, BA. Medical Student Research. Proenkephalin and risk of stroke in a bi- racial cohort. Medical Student Research. UVM Cardiovascular Research Institute of Ver- mont (CVRI) Summer Research Award 2020. Mentored by Mary Cushman Alexander Karabachev, UVM LCOM Class of 2021 Mentored by Marc Greenblatt Maeve Dillon-Martin, UVM Class of 2022 Mentored by Marc Greenblatt Cinduja Nathan-Medical Student Research. Venous thromboembolism prevention in the ambulatory cancer clinic (VTE PACC). Mentored by Chris Holmes Kara Landry, MD Mentored by Marie Wood Nick Farina, PhD Mentored by Marie Wood Alexander Karabachev, Mentored by Marc Greenblatt Louise-Basset Porter, Mentored by Kim Dittus Jordan Munger, BS: Inaugural Dean’s research fellowship 2020-21. Mentored by Neil Zakai

Leadership in Professional Societies

Jose Acostamadiedo, MD Cancer Liaison Physician for Fitzpatrick Cancer Center

Steven Ades, MD Member, Board of Directors Northern New England Clinical Oncology Society Member, Alliance Symptom Intervention Committee Member, ASCO Upper Gastrointestinal Oncology Annual Meeting Planning Committee

Diego Adrianzen Herrera, MD Member, American Society of Clinical Oncology (ASCO): Career Conversations Mentor, Trainee and Early Career Council. Member, Northern New England Clinical Oncology Society (NNECOS): Grant Reviewer Committee

Shahid Ahmed, MD, MBBS Member, ALLIANCE cooperative group Immuno-Oncology committee Member, NNECOS grant review committee Member, American Society of Clinical Oncology Member, American Society of Hematology Member, Northern New England Clinical Oncology Society

Maura Barry, MD Member, American Society of Clinical Oncology Member, Northern New England Clinical Oncology Society Member, Multinational Association of Supportive Care in Cancer

Mary Cushman, MD, MSc Member, Quality Committee, American Society of Hematology Member, Media Experts Committee, American Society of Hematology Member, Leadership Council of the International Society on Thrombosis and Haemosta- sis, ex officio non-voting Publishing Committee (ex officio), International Society on Thrombosis and Hemostasis Medical Advisory Committee, Foundation for Women & Girls with Blood Disorders Planning Committee, 2020 HTRS/NASTH Research Colloquium, Developing a Sustaina- ble Research Career in Hemostasis and Thrombosis Chair, Task Force on Women in Science and Medicine, American Heart Association Chair, 2020 Women’s Triennial Health Tracking Study in Cardiovascular Disease and Stroke. American Heart Association Board Director, Hemostasis and Thrombosis Research Society Board Director, Eastern States Affiliate, American Heart Association Research Funding Subcommittee of the Research Committee, American Heart Associa- tion Board Director, UVM Cardiovascular Research Institute Advisor, Early Career Advisory Committee of the Cardiovascular Research Institute Member, Nominating Committee, Larner College of Medicine, University of Vermont Chair, University of Vermont Faculty Senate Research, Scholarship, and Creative Arts Committee Member, Medical Alumni Executive Committee

Kim Dittus, MD, PhD Member, Cancer Control Committee, UVM Medical Center

Marc Greenblatt, MD President, Human Genome Variation Society (HGVS) Member, International Scientific Advisory Council, Human Variome Project Working Group Member, American Association of Cancer Research Member, American Society of Clinical Oncology Member, American Society of Human Genetics Member, Collaborative Group of the Americas of Inherited Colorectal Cancer (CGA- ICC) Member, International Mismatch Repair Consortium (IMRC) Member, Vermont Medical Society

Chris Holmes, MD, PhD Executive Board Member, National Network, Health and Human Services New England Comprehensive Hemophilia Diagnostic and Treatment Centers Director, Community Counts-Vermont, Centers for Disease Control (CDC) Public Health Monitoring Program, Division of Blood Disorders Member, Institutional Review Board, Committee on Human Research in the Medical Sci- ences (CHRMS), University of Vermont Member, American Society of Hematology Member, Northern New England Clinical Oncology Society Member, Thrombosis Committee, American Thrombosis and Hemostasis Network, Cen- ters for Disease Control National Chair, Hemophilia Transitions, American Society of Hematology Workgroup on Transitions; American College of Physicians Pediatric to Adult Care Transition Initiative

Sakshi Jasra, MD Member, American Society of Hematology Member, Northern New England Clinical Oncology Society

Peter Kaufman, MD Committee Member, Breast Cancer Core Committee, Alliance for Clinical Trials in On- cology Breast Cancer Committee Liaison to Neuro-Oncology, Alliance for Clinical Trials in On- cology Alliance Champion, E2112, A Randomized Phase III Trial of Endocrine Therapy Plus Entinostat or Placebo in Patients with Hormone Receptor Positive Advanced Breast Can- cer Co-Investigator, A071701, Genomically Guided Trial in Brain Metastases (CTEP Ap- proved) Board of Directors, Alliance for Clinical Trials in Oncology

Farrah Khan, MD Member, American Society of Clinical Oncology Member, Northern New England Clinical Oncology Society

Member, International Association for the Study of Lung Cancer Member, American Society of Clinical Oncology Member, Alliance for Clinical Trials in Oncology

Saranya Kodali, MD Member, Alliance for Clinical Trials in Oncology Member, NRG Oncology Member, American Society of Clinical Oncology Member, American Society of Hematology Member, American Society for Blood and Marrow Transplantation Member, American College of Physicians Member, Massachusetts Medical Society

Patricia O’Brien, MD Member, American Physical Therapy Association- Oncology Rehabilitation Educational Hibba tul Rehman, MD Member, American Society of Clinical Oncology Member, American Society of Hematology Member, Northern New England Strategic Planning Committee Member, Northern New England Educational Committee Member, Immuno Oncology Subcommittee for Alliance for Clinical Trials

Julian Sprague, MD Member, American Society of Hematology Member, American Society of Clinical Oncology Member, Northern New England Clinical Oncology Society Member, Committee on Training, American Society of Hematology Liaison, Committee on Quality from the Committee on Training, American Society of Hematology Member, Alliance Myeloma Subcommittee

Elvira Umyarova, MD Member, American Society of Hematology Member, Northern New England Clinical Oncology Society

Paul Unger, MD Immediate Past President, Northern New England Oncology Society Member, American Society of Clinical Oncology Quality Oncology Project Initiative (QOPI) Steering Committee

Marie Wood, MD Co-Chair, Alliance, Prevention Committee Member, Alliance Foundation, Board of Trustees Member, NCI Prevention Steering Committee Member, American Society of Clinical Oncology, CME Committee Member, Northern New England Clinical Oncology Society Board of Directors

Member, American College of Physicians Member, National Surgical Adjuvant Breast and Bowel Project Chair, ASCO Continuing Education Committee Member, NCI Cancer Prevention and Control

Neil Zakai, MD American Heart Association (AHA) Member, Executive Committee, American Heart Association Council on Epide- miology and Prevention Member (past chair), American Heart Association Council on Epidemiology and Prevention, Publications Committee American Heart Association Council on Epidemiology and Prevention March 2019 meeting (Houston TX) American Society of Hematology (ASH) Member, American Society of Hematology COVID 19 research initiative on benign hematology. Member, American Society of Hematology VTE Guideline Panel: Prevention of VTE in Medical Patients Member, American Society of Hematology “Consult a Colleague” Program-  Content expert “Hemostasis/Thrombosis”  Content expert “Anemias” Faculty, American Society of Hematology Clinical Research Training Institute (2016, 2017, 2018, 2019, 2020) Member 2019-2021, American Society of Hematology Organizing Committee for Highlights of ASH (organizing 12 domestic and 6 international meetings) Hemophilia and Thrombosis Research Society (HTRS)  Vice-Chair 2020 Mentored Research Award Committee  Abstract Reviewer Hemophilia and Thrombosis Research Society April 2019 Meeting (New Orleans, LA)  Mentored Research Award Grant Reviewer 2020-21 International Society of Thrombosis and Haemostasis  Working group: Standardization of data elements for research on anticoagulation

Editorships and Editorial Boards

Jose Acostamadiedo, MD Editorial Board Colombian Society of Hematology Oncology Magazine (ACHO) Shahid Ahmed, MD Associate – Mednet Reviewer – Journal of Clinical Oncology, Precision Oncology Mary Cushman, MD Inaugural Editor-in-Chief, Research and Practice in Thrombosis and Haemostasis Editorial Board, Circulation

Marc Greenblatt, MD Contributing Editor, Human Mutation Patricia O’Brien, MD Board, Multinational Association of Supportive Care in Cancer, reviewing lymphedema Publication Review for California Breast Cancer Research Program Review Grant Applications for Funding Marie Wood, MD Editorial Board, The Breast Editorial Board, Journal of the National Cancer Institute Editor in Chief, ASCO University (eLearning platform) Section Editor, Current Breast Concur Reports Neil Zakai, MD Editorial Board, Research and Practice of Thrombosis and Haemostasis

Study Sections and Federal Advisory Boards

Mary Cushman, MD, MSc 9-10-2019 Expert Panel, Hormonal Contraceptive Use Among Women with Medical Condi- tions that Increase Thrombosis Risk. Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 3/23/2020 Expert Panel, COVID-19 Treatment Trials, National Heart, Lung, and Blood In- stitute. 4/3/2020 NHLBI Roundtable on Acute Care Cohort / Longitudinal Cohort / National Reg- istry of COVID-19 Patients

Chris Holmes, MD, PhD NIH, Patient-Centered Outcomes Research Institute (PCORI), merit review panel member, Man- agement of Care Transitions for Emerging Adults with Sickle Cell Disease NIH, National Heart, Lung, and Blood Institute (NHLBI), ad-hoc member, Clinical Trials Re- view Committee (CLTR) Center for Disease Control/American Thrombosis and Hemostasis Network Community Project Review Committee Marie Wood, MD Member, NCI Steering Committee

Grants

Steven Ades PROMISE Trial Ades (PI) 01/01/19-12/31/20 UVMCC 1902-Prostate Cancer Circulating miRNAs for Precision-based Medicine Role: PI

NNECOS Ades (PI) 01/15/20-06/16/21 VTE Risk Assessment and Prevention in Cancer Patients in the Community Oncology Setting Role: PI

Mary Cushman NINDS 02/15/18-01/31/23 U01 NS041588 VCID and Stroke in a Bi-Racial National Cohort S Judd, Contact PI, University of Alabama at Birmingham G Howard, MPI, University of Alabama at Birmingham J Manly, MPI Columbia University Role: MPI, 25%

NHLBI 4/1/17-03/31/20 (NCE) R01 HL59367 Epidemiology of Venous Thrombosis and Pulmonary Embolism AR Folsom, PI, University of Minnesota Role: Subcontract PI, 15, 10, 10 in current project

NHLBI 08/15/00-12/18/25 HHSN2682015000031 Multiethnic Study of Atherosclerosis R. McClelland, PI, University of Washington Role: Subcontract Co-I, 5%

NIH 07/01/14-4/30/20 (NCE) P01HD03192116A1 The National Longitudinal Study of Adolescent Health - Wave V K Harris, PI, University of North Carolina, Chapel Hill Role: Subcontract PI, 5%

NIH NICHD 09/09/16-05/31/20 Social Context, Life Course and Genetic Transcription in Add Health K Harris, PI, University of North Carolina, Chapel Hill Role: Subcontract PI, 2%

NIH-NIA 06/01/16-05/31/21 Transitions to Family Caregiving and its Impact on Health Indicators Role: Subcontract PI, 10% 4%

NIH-NIMHD 08/14/18-03/31/22 R01 MD013349 The Add Health Epigenome Resource: Life course stressors and epigenomic modications in adulthood K Harris, PI, University of North Carolina, Chapel Hill Role: Subcontract PI, 2.5%

NIH-NIA 03/01/19-02/28/23 R01 AG061186

Use of High Density Lipoprotein Proteome in the Prediction of Cognitive Impairment and Alzheimer’s Disease: (REGARDS) RS Rosenson, R. Sidney, PI’s, Mount Sinai School of Medicine Role: Subcontract PI, 5%

NIH-NHLBI 05/15/19-02/28/23 R01 HL141290 Thrombosis and Bleeding Risk Assessment in Medical Inpatients N Zakai, PI, University of Vermont Role: Co-Investigator, 5%

Kim Dittus 036831 Dittus/Stein (Co-PI) 09/01/19-06/30/20 Vermont AHS Department of Health Award “CoC Survivorship Grant” Role: Co-PI

Marc Greenblatt NIH-NHGRI Berg, Jonathan (PI) 09/01/13-08/31/21 U01 HG007437-01 A Knowledge Base for Clinically Relevant Genes and Variants Role: Co-Investigator

UVM Cancer Center Pilot Project Wood, Marie (PI) 01/2020 – 12//2021 Point of Care Testing for Patients with Advanced Cancer (PoC-TAC): A feasibility study Role: Co-Investigator

Chris Holmes

NNE-CTR/NIGMS 06/2020 Improving VTE Risk Assessment: Education and Prophylaxis in Rural Cancer Clinics Role: PI

NNECOS 01/15/20-04/30/21 VTE Risk Assessment and Prevention in Cancer Patients in the Community Oncology Setting S. ADES, PI Role: Co-investigator

5H30MC24048-04-00 Walsh (PI) 06/01/10-05/31/21 Department of Health and Human Services Human Resources and Services Administration Hemophilia Treatment Centers (SPRANS) Role: Collaborating PI

ATHN2011001-1-1 Croteau (PI) 09/30/11-09/29/20 Centers for Disease Control and Prevention

American Thrombosis and Hemostasis Network Public Health Surveillance for the Prevention of Complications of Bleeding and Clotting Disorders Role: Co-Investigator

NIH-NHLBI05/15/19-02/28/23 R01 HL141290 Thrombosis and Bleeding Risk Assessment in Medical Inpatients N Zakai, PI, University of Vermont Role: Co-Investigator

Peter Kaufman, MD Industry Sponsored Kaufman (International Co-Chair) 06/10/19-Ongoing Clinical Research Grant Polyphor Pharma An International, Phase 3, Multicenter, Randomized, Open-Label Trial Comparing Ba- lixafortide in combination with Eribulin versus Eribulin alone in Patietns with HER2 negative, Locally Recurrent or Metastatic Breast Cancer (FORTRESS)

Marie Wood Alliance 31828 Wood (PI) 08/01/17-11/04/21 Prevention Committee Co-Chair/Concept Role: PI

5UG1CA189823-06 Buckner/Paskett (Co-PI’s) 08/01/14-07/31/25 NIH/NCI Alliance NCORP Research Base Prevention Committee Co-Chair Role: Subaward PI

Dana Farber Cancer Institute 09/15/19-09/14/20 DOD Prospectively Randomized, Placebo-Controlled Phase III Study to Determine the Effect of Denosumba on Breast Cancer Prevention in BRCA1 Mutation Carriers Role: Subaward PI

NNECOS Wood (PI) 08/15/2019-08/14/2020 Examination of Attitudes, Beliefs and Practices Regarding Point-of-Care Genetic Testing Among Northern New England medical Oncologists Pilot award Role: PI

UVM Cancer Center Wood (Co-PI) 01/01/2020-12/31/2021 Point of Care (POC) Testing for Patients with Advanced Cancer (PoC-TAC): A feasibility study Pilot award

Role: Co-PI

Neil Zakai NIH-NHLBI Zakai (PI) 05/15/19-02/28/23 R01 HL141290 Thrombosis and Bleeding Risk Assessment in Medical Inpatients Each year there are 10 million non-surgical admissions to hospitals in the United States, which are associated with 200,000 venous thromboembolism (VTE) events and an equal or greater number of bleeding events. Despite a lack of validated risk models , providers are required to assess VTE and bleeding risk on admission to the hospital, and provide VTE prophylaxis to those at low risk of bleeding and high risk of VTE. Our goals, in two complementary healthcare systems (located at the University of Vermont and the Univer- sity of Washington), are to develop and validate robust models to assess hospital-ac- quired bleeding and VTE risk, and determine the period of increased risk for bleeding and VTE after discharge from the hospital Role: PI 30%

U01 NS041588 Howard (PI) 02/15/18-01/31/23 NINDS VCID and Stroke in a Bi-racial National Cohort This study plans to extend follow-up for incident stroke and cognitive decline in a national cohort of 30,000 black and white community dwelling participants. This proposal will identify mechanisms of racial and geographic disparities in dementia, and identify pathways and biomarkers for the development of hypertension and diabetes Role: Subcontract—Co investigator 10%

R01HL131579 Lutsey (PI) 01/01/17-11/30/20 NIH/NHLBI Contemporary Venous Thromboembolism Treatment Recent introduction of novel oral anticoagulant drugs have transformed the management of venous thromboembolism (VTE), however we have little real-world experience with the side-effects of these medications. This grant uses data from two large U.S. commer- cial claims databases (OptumInsight and MarketScan) to see whether real-life outcomes differ between traditional treatment of VTE and novel treatments and if bleeding and recurrent thrombosis differ Role: Co-Investigator

R01 HL132947 Reiner (PI) 04/01/17-03/31/21 NIH Thrombosis Genetics in African Americans The primary objective of this project is to measure several emerging thrombosis and inflammation plasma biomarkers that are likely to reflect and/or account for increased thrombogenicity and therefore may contribute to higher rates of CVD in African Ameri- cans, and to assess the association of thrombosis biomarkers and biomarker-associated genetic variants with more complex subclinical and clinical CVD endpoints available in JHS and other African American cohorts, including REGARDS

Role: Subcontract Investigator

RO1 HL136373 Pamir (PI) 01/15/18-12/31/22 NIH Identification of the Role of HDL Function in Human Cardiovascular Disease through Proteomics and Genetics. The primary aims seek to assess whether high-density lipoprotein cholesterol efflux capacity and the protein composition of HDL provide predictive value of assessing the risk of coronary heart disease and stroke in Caucasian and African-Americans relative to HDL cholesterol and apolipoprotein A1 levels Role: Subcontract Investigator

R01 Allison (PI) 07/01/18-06/30/22 NIH Treatment of Venous Leg Ulcers with Factor Xa Inhibition: Efficacy and Mechanisms This proposal will explore clinical aspects of venous leg ulcers, post-thrombotic syndrome and anticoagulation treatment, and will relate biomarker levels to ulcer characteristics and healing Role: Subcontract Investigator

NIH Kanaya (PI) 04/01/19-03/31/25 Tri-Asian Cohort on Cardiometabolic (TRACC) Health The general aim of this proposal is to provide fundamental clinical and biological data about cardiometabolic risk factor profiles including magnetic resonance imaging of the heart, great vessels, abdomen; to track changes in behavioral, psychological, sociocultural and contextual factors among Asian immigrants; and to investigate mechanisms that influence cardiometabolic risk aortic stiffness, hepatic and myocardial fibrosis Role: Subcontract PI

Publications

Howard G, Cushman M. Inclusivity of Diverse Patient Groups-Reply. JAMA Neurol. 2019 Jun 3. doi: 10.1001/jamaneurol.2019.1390. PMID: 31157829

Lutsey PL, Zakai NA, MacLehose RF, Norby FL, Walker RF, Roetker NS, Adam TJ, Alonso A. Risk of hospitalized bleeding in comparisons of oral anticoagulant options for the primary treatment of venous thromboembolism. Br J Haematol. 2019 June: 185(5):903-911. doi: 10.1111/bjh.15857. PMID: 30919942

Cruden P, Cushman M, Repp AB. Hospitalist assessment of venous thromboembolism and bleeding risk. A survey study. Thromb Res 2019 Jun:178: 155-158. doi: 10.1016/j.thromres.2019.04.015. PMID: 31030035

Wood ME, Garber JE, Isaacs C, Masood S, Bedrosian I, Tung N, Chun J, Schnabel FR, Arun BK; International Society of Cancer Risk Assessment and Management. Genetic testing for hereditary breast and ovarian cancer and the USPSTF recommendations. Breast J. 2019 Jul;25(4):575-577. doi: 10.1111/tbj.13292. PMID: 31280501

Wood ME, Cuke M, Bedrosian I. Prevention Therapy for Breast Cancer: How Can We Do Bet- ter? Ann Surg Oncol. 2019 Jul;26(7):1970-1972. doi: 10.1245/s10434-019-07243-9. PMID: 30798445

Drost M, Tiersma Y, Thompson BA, Frederiksen JH, Keijzers G, Glubb D, Kathe S, Osinga J, Westers H, Papas L, Boucher KM, Molenkamp S, Zonneveld JB, van Asperen CJ, Goldgar DE, Wallace SS, Sijmons RH, Spurdle AB, Reasmussen LJ, Greenblatt MS, de Wind N, Tavtigian SV. A functional assay-based procedure to classify mismatch repair gene variants in Lynch syndrome. Genet Med. 2019 Jul:21(7):1486-1496. doi: 10.1038/s41436-018-0372-2. PMID: 30504929

Li A, Wu Q, Luo S, Warnick GS, Zakai NA, Libby EN, Gage BF, Garcia DA, Lyman GH, San- filippo KM. Derivation and Validation of a Risk Assessment Model for Immunomodulatory Drug-Associated Thrombosis Among Patients with Multiple Myeloma. J Natl Compr Canc Netw. 2019 Jul 1;17(7):840-847. doi: 10.60004/jnccn.2018.7273. PMID: 31319391

Seifert BA, McGlaughon JL, Jackson SA, Ritter DI, Roberts ME, Schmidt RJ, Thompson BA, Jimenez S, Trapp M, Lee K, Pion SE, Offit K, Stadler ZK, Zhang L, Greenblatt MS, Ferber MJ. Determining the clinical validity of hereditary colorectal cancer and polyposis susceptibility genes using he Clinical Genome Resource Clinical Validity Framework. Genet Med. 2019 Jul;21(7):1507-1516. doi: 10.1038/s41436-018-0373. PMID: 30523343

Khan F, Rahman A, Carrier M, Kearon C, Weitz JI, Schulman S, Couturaud F, Eichinger S, Kyrle PA, Becattini C, Agnelli G, Brighton TA, Lensing AWA, Prins MH, Sabri E, Hutton B, Pineda L, Cushman M, Palareti G, Wells GA, Prandoni P, Buller HR, Rodger MA; MARVEL- OUS Collaborators. Long term risk of symptomatic recurrent venous thromboembolism after dis- continuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis. BMJ. 2019 Jul 24;366:14363. doi: 10.1136/bmj.14363. PMID: 31340984

Malek AM, Vladutiu CJ, Meyer ML, Cushman M, Newman R, Lisabeth LD, Kleindorfer D, Lakkur S, Howard VJ. The association of age at menopause and all-cause and cause-specific mortality by race, postmenopausal hormone use, and smoking status. Prev Med Rep. 2019 Jul 14;15:100955. doi: 10.1016/j.pmedr.2019.100955. PMID: 31367516

Dominguez-Valentin M, Sampson JR, Seppala TT, Ten Broeke SW, Plazzer JP, Nakken S, En- gel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Thomas H, Evans DG, Burns J, Greenblatt M, Hovig E, de Vos Tot Nederveen Cappel WH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A, Lopez-Kostner F, Gluck N, Katz LH, Heinimann K, Vaccaro CA, Buttner R, Gorgens H, Holinski-Feder E, Morak M, Holzapfel S, Huneburg R, Knebel Doeberitz MV, Loeffler M, Rahner N, Schackert HK, Steinke-Lange V, Schmiegel W, Vangala D, Pylvanainen K, Renkonen-Sinisalo L, Hopper JL, Win AK, Haile

RW, Lindor NM, Gallinger S, Le Marchand L, Newcomb PA, Figueiredo JC, Thibodeau SN, Wadt K, Therkildsen C, Okkels H, Ketabi Z, Moreira L, Sanchez A, Serra-Burriel M, Pineda M, Navarro M, Blanco I, Green K, Lalloo F, Crosbie EJ, Hill J, Denton OG, Frayling IM, Rodland EA, Vasen H, Mints M, Neffa F, Esperon P, Alvarez K, Kariv R, Rosner G, Pinero TA, Gonza- lez ML, Kalfayan P, Tjandra D, Winship IM, Macrae F, Moslein G, Mecklin JP, Nielsen M, Moller P. Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database. Genet Med. 2019 Jul 24. doi: 10.1038/s41436-019-0596-9. PMID: 31337882

Croteau SE, Cheng D, Cohen AJ, Holmes CE, Malec LM, Silvey M, Thornburg CD, Wheeler AP, Kouides PA, Raffini LJ, Neufeld EJ. Regional variation and cost implications of prescribed exended half-life factor concentrates among U.S. Haemophilia Treatment Centers for patients with moderate and severe haemophilia. Haemophilia. 2019 Jul;25(4):668-675. doi: 10.1111/hae.13758. PMID: 30993845

Averill AM, Rehman HT, Charles JW, Dinh TA, Danyal K, Verschraegen CF, Stein GS, Dostmann WR, Ramsey JE. Inhibition of the chimeric DnaJ-PKAc enzyeme by endogenous inhibitor proteins. J Cell Biochem. 2019 Aug;120(8):13791. doi: 10.1002/jcb.28651. PMID: 30938854

Evans CR, Long DL, Howard G, McClure LA, Zakai NA, Jenny NS, Kissela BM, Safford MM, Howard VJ, Cushman M. C-reactive protein and stroke risk in blacks and whites: the REasons for Geographic and Racial Differences in Stroke cohort. Am Heart J. 2019 Aug 12;217:94-100. doi: 10.1016/j.ahj.2019.08.003. PMID: 31520899

Parikh RR, Folsom AR, Misialek JR, Rosamond WD, Chang PP, Tang W, Cushman M. Pro- spective study of plasma high molecular weight kininogen and prekallikrein and incidence of coronary heart disease, ischemic stroke and heart failure. Thromb Res 2019 Aug 22;182:89-94. doi: 10.1016/j.thromres.2019.08.009. PMID: 31473403

Akinyemiju T, Moore JX, Pisu M, Goodman M, Howard VJ, Safford M, Gilchrist SC, Cushman M, Long L, Judd SE. Association of baseline inflammatory biomarkers with cancer mortality in the REGARDS cohort. Oncotarget. 2019 Aug 6;10(47):4857-4867. doi: 10.18632/oncotarget.27108. PMID: 31448052

Grams ME, Surapaneni A, Ballew SH, Appel LJ, Boerwinkle E, Boulware LE, Chen TK, Coresh J, Cushman M, Divers J, Gutierrez OM, Irvin MR, Ix JH, Kopp JB, Kuller LH, Langefeld CD, Lipkowitz MS, Mukamal KJ, Musani SK, Naik RP, Pajewski NM, Peralta CA, Tin A, Wassel CL, Wilson JG, Winkler CA, Young BA, Zakai NA, Freedman BI. APOL1 Kidney Risk Vari- ants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis. J Am Soc Nephrol. 2019 Aug 5 pii. ASN.2019030240. doi: 10.1681/ASN.2019030240. PMID: 31383730

Wood M, George TJ, Manochakian R, Polansky M, Baer A, Grupe A, Shyr Y, Wang C, Horn L. Quantitative Assessment of Learning Behaviors for Oncology Providers. J Cancer Educ 2019 Aug 3. doi: 10.1007/s13187-019-01593-4. PMID: 31377987

Gell NM, Tursi A, Grover KW, Dittus K. Female cancer survivor perspectives on remote intervention components to support physical activity maintenance. Support Care Cancer. 2019 Aug 17. doi: 10.1007/s00520-019-05038-y. PMID: 31422476

Cushman M. #WomenInMedicine: Progress in gender equity at Research and Practice in Thrombosis and Haemostasis. Res Pract Thromb Haemost 2019 Sep 25;3(4):560-562. doi: 10.1002/rth2.12257. PMID: 31624773

Cushman M. #WomenInMedicine: Progress in gender equity at Research and Practice in Thrombosis and Haemostasis. Res Pract Thromb Haemost 2019 Sept 25;3:560-562. doi: 10.1002/rth2.12257. PMID: 31624773

Ghandi UH, Cornell RF, Lakshman A, Gahvari Z, McGehee E, Jagosky MH, Gupta R, Varnado W, Fiala MA, Chhabra S, Malek E, Mansour J, Paul B, Barnstead A, Kodali S, Neppalli A, Liedtke M, Narayana S, Godby KN, Kang Y, Kansagra A, Umyarova E ,Scott EC, Hari P, Vij R, Usmani SZ, Callander NS, Kumar SK, Costa LJ. Outcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy. Leukemia. 2019 Sep;33(9):2266-2275. doi: 10.1038/s41375-019-0435. PMID: 30858549

Doyle-Lyons K, Bruce ML Hull JG, Kaufman PA, Zhongze L, Stearns DM, Lansigan F, Cham- berlin M, Fuld A, Bartels SJ, Whipple J, Bakitas MA, Hegel MT. Health Through Activity: Ini- tial Evaluation of an In-Home Intervention for Older Adults with Cancer. Am J Occup Ther. 2019 Sep-Oct; 73(5): 7305205070p1-7305205070p11. doi: 10.5014/ajot.2019.035022. PMID: 31484031

Grams ME, Surapaneni A, Ballew SH, Appel LJ, Boerwinkle E, Boulware LE, Chen TK, Coresh J, Cushman M, Divers J, Gutiérrez OM, Irvin MR, Ix JH, Kopp JB, Kuller LH, Langefeld CD, Lipkowitz MS, Mukamal KJ, Musani SK, Naik RP, Pajewski NM, Peralta CA, Tin A, Wassel CL, Wilson JG, Winkler CA, Young BA, Zakai NA, Freedman BI. APOL1 kidney risk variants and cardiovascular disease: An individual participant data meta-analysis. J Am Soc Nephrol 2019 Oct;30:2027-2036. doi: 10.1681/ASN.2019030240. PMID: 31383730

Evans CR, Long DL, Howard G, McClure LA, Zakai NA, Jenny NS, Kissela BM, Safford MM, Howard VJ, Cushman M. C-reactive protein and stroke risk in blacks and whites: The REasons for Geographic And Racial Differences in Stroke cohort. Am Heart J 2019 Nov;217:94-100. doi: 10.1016/j.ahj.2019.08.003. PMID: 31520899

Mefford MT, Marcovina SM, Bittner V, Cushman M, Brown TM, Farkouh ME, Tsimikas S, Monda KL, Lopez JAG, Muntner P, Rosenson R. PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults. J Lipid Res 2019 Nov;60:1946-1952. doi: 10.1194/jlr.P119000173. PMID: 31511398

Walker RF, Zakai NA, MacLehose RF, Cowan LT, Adam LT, Alonso A, Lutsey PL. Associa- tion of Testosterone Therapy with Risk of Venous Thromboembolism Among Men with and without Hypogonadism. JAMA Intern Med. 2019 Nov 11. doi: 10.1001/jamaintern- med.2019.5135. PMID: 31710339

Manochakian R, George TJ, Wood M, Polansky M, Baer A, Grupe A, Shyr Y, Wang C, Horn L. Establishing and Evaluating an ASCO Learning Cohort: a Longitudinal Project Assessing the Learning Needs and Behaviors of Oncology Professionals. J Cancer Educ. 2019 Nov 18. doi: 10.1007/s13187-019-01649-5. PMID: 31741200

Adrianzen Herrera D, Pradham K, Snyder R, Karanth S, Janakiram M, Mantzaris I, Braun- schweig A, Shah UA, Verma AK, Murthy SB, Shastri A. Myelodysplastic Syndromes and the Risk of Cardiovascular Disease in Older Adults: A SEER-medicare Analysis. Leukemia 2019 Dec 16. doi: 10.1038/s41375-019-0673-8. PMID: 31844145

Douce DR, Holmes CE, Cushman M, MacLean C, Ades S, Zakai NA. Risk factors for cancer- associated venous thromboembolism: the Venous Thromboembolism Prevention in the Ambula- tory Cancer Clinic (VTE-PACC) Study. J Thromb Haemost 2019 Dec;17:2152-2159. doi: 10.1111/jth.14614. Epub 2019 Sep 22 PMID: 31423717

Jasra, S., Giricz, O., Zeig-Owens, R., Goldfarb, D., Barreto-Galvez, A., Pradhan, K, Shastri, A. (2019). High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster (Presented at the American Society of Hematology, December 2019)

Kaner JD, Thibaud S, Jasra S, Wang Y, Janakiram M, Sharma A, Sridharan A, Elias H, Polineni R, Assal A, Weiss L, Braunschweig I, Steidl U, Pradhan K, Shastri A, Chaitowitz M, Zingman B, Will B, Mantzaris I, Verma A. HIV portends a poor prognosis in myelodysplastic syndromes. Leuk Lymphoma. 2019 Dec;60(14):3529-3535. doi: 10.1080/10428194.2019.1633631. PMID: 31282240

Waheed W, Taicher C, Dulaney E, Eckenstein F, Hehir M, Sprague J, Tandan R. Intraepidermal Nerve Fiber Density in Postmortem Skin: A Novel Approach. J Clin Neuromuscul Dis. 2019 Dec;21(2): 69-76. doi: 10.1097/CND.0000000000000264. PMID: 31743249

Krok-Schoen JL, Naughton MJ, Young GS, Moon J, Poi M, Melin SA, Wood ME, Hopkins JO, Paskett Ed, Post DM. Cancer Control. 2019 Jan-Dec;26(1):1073274819883287. doi: 10.1177/1073274819883287. PMID: 31736324

Yang X, Leslie G, Doroszuk A, Schneider S, Allen J, Decker B, Dunning AM, Redman J, Scarth J, Plaskocinska I, Luccarini C, Shah M, Pooley K, Dorling L, Lee A, Adank MA, Adlard J, Ait- tomaki K, Andrulis IL, Ang P, Barwell J, Bernstein JL, Bobolis K, Borg A, Blomqvist C, Claes KBM, Concannon P, Cuggia A, Culver JO, Damiola F, de Pauw A, Diez O, Dolinsky JS, Dom- chek SM, Engel C, Evans DG, Fostira F, Garber J, Godde EL, Gruber SB, Hahnen F, Hake C, Heikkinen T, Hurley JE, Janavicius R, Kleibl Z, Kleiblova P, Konstantopoulou I, Kyst A, La- duca H, Lee ASG, Lesuer F, Maher ER, Mannermaa A, Manoukian S, McFarlandd R, McKin- non W, Meindl A, Metcalfe K, Mohd Taib NA, Moilanen J, Nathanson KL, Nehausen S, Nq PS, Nguyen-Dumont T, Nielsen SM, Obrmair F, Offit K, Olopade OI, Ottini L, Penkert J. Pylkas K, Radice P, Ramus SJ, Rudaitis V, Side L, Silva-Smith R, Silvestri V, Skytte AB, Slavin T, Soukupova J, Tondini C, Trainer AH, Unzeitig G, Usha L, van Overeem Hansen T, Whitmore J, Wood M, Yip CH, Yoon SY, Yussuf A, Zoqopoulos G, Goldgar D, Hopper JL, Chenevix- Trench G, Pharoah P, George SHL, Balmana J, Houdayer C, James P, El-Haffaf Z, Ehrencrona

H, Janatova M, Peterlongo P, Nevanlinna H, Schmutzler R, Tea SH, Robson M, Pal T, Couch F, Weitzel JN, Elliott A, Southey M, Wingvist R, Easton DF, Foulkes WD, Antoniou AC, Tischko- witz M. Cancer Risks Associated with Germline PALB2 Pathogenic Variants: An International Study of 524 Families. J Clin Oncol. 2019 Dec 16: JCO1901907. doi: 10.1200/JCO.19.01907. PMID: 31841383

Brnich SE, Abou Tayoun AN, Couch FJ, Cutting GR, Greenblatt MS, Heinen CD, Kanavy DM, Luo X, McNulty SM, Starita LM, Tavtigian SV, Wright MW, Harrison SM, Biesecker LG, Berg JS, Clinical Genome Resource Sequence Variant Interpretation Working Group. Recommenda- tions for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework. Genome Med. 2019 Dec 31;12(1):3. doi: 10.1186/s13073-019-0690-2. PMID: 31892348

Wood ME, Rehman HT, Bedrosian I. Importance of family history and indications for genetic testing. Breast J. 2019 Dec 22. doi: 10.1111/tbj.13722. PMID: 31865627

Dittus K, Toth M, Priest J, O’Brien P, Kokinda N, Ades P. Effects of an exercise-based oncology rehabilitation program and age on strength and physical function in cancer survivors. Sup- port Care Cancer. 2019 Dec 11. doi: 10.1007/s00520-019-05163-8. PMID: 31828490

Kowalski MH, Qian H, Hou Z, Rosen JD, Tapia AL, Shan Y, Jain D, Argos M, Arnett DK, Avery C, Barnes KC, Becker LC, Bien SA, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Buyske S, Cai J, Cho MH, Choi SH, Choquet H, Cupples LA, Cushman M, Daya M, de Vries PS, Ellinor PT, Faraday N, Fornage M, Gabriel S, Ganesh SK, Graff M, Gupta N, He J, Heckbert SR, Hidalgo B, Hodonsky CJ, Irvin MR, Johnson AD, Jorgenson E, Kaplan R, Kardia SLR, Kelly TN, Kooperberg C, Lasky-Su JA, Loos RJF, Lubitz SA, Mathias RA, McHugh CP, Mont- gomery C, Moon JY, Morrison AC, Palmer ND, Pankratz N, Papanicolaou GJ, Peralta JM, Pey- ser PA, Rich SS, Rotter JI, Silverman EK, Smith JA, Smith NL, Taylor KD, Thornton TA, Ti- wari HK, Tracy RP, Wang T, Weiss ST, Weng LC, Wiggins KL, Wilson JG, Yanek LR, Zöllner S, North KE, Auer PL, Raffield LM, Reiner AP, Li Y, for the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology & Hemostasis Working Group. Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed Af- rican and Hispanic/Latino populations. PLOS Genet 2019 Dec 23. doi: 10.1371/journal.pgen.1008500. PMID: 31869403

Folsom AR, Lutsey PL, Pope ZC, Fashanu OE, Misialek JR, Cushman M, Michos ED, for the Atherosclerosis Risk in Communities (ARIC) Study Investigators. Resting heart rate and incidence of venous thromboembolism. Res Pract Thromb Haemost 2019 Dec 4(2),238-46. PMID: 32110754

Chaudhary NS, Bridges SL Jr, Saag KG, Rahn EJ, Curtis JR, Gaffo A, Limdi NA, Levitan EB, Singh JA, Colantonio LD, Howard G, Cushman M, Flaherty ML, Judd S, Irvin MR, Reynolds RJ. Severity of hypertension mediates the association of hyperuricemia with stroke in the RE- GARDS case cohort study. Hypertension 2020 Jan;75:246-56. PMID: 31786980

Fanola C, Norby FL, Shah AM, Chang PP, Lutsey PL, Rosamond WD, Cushman M, Folsom AR. Incident heart failure and long-term risk of venous thromboembolism: the Atherosclerosis Risk in Communities Study. J Am Coll Cardiol 2020 Jan;75:148-58. PMID: 31948643

Gutiérrez OM, Irvin MR, Zakai NA, Naik RP, Chaudhary NS, Estrella MM, Limou S, Judd SE, Cushman M, Kopp JB, Winkler CA. APOL1 nephropathy risk alleles and mortality in African American adults: a cohort study. Am J Kidney Dis 2020 Jan;75:54-60. PMID: 31563468

Sledge Jr GW, Toi M, Neven P, Sohn J, Inoue K, Pirot X, Burdaeva O, Okera M, Masuda N, Kaufman PA, Koh H, Grischke EM, Conte PF, Lu Y, Barriga S, Hurt K Frenzel M, Johnston S, Llombart-Cussac A. The Effect of Abemaciclib Plus Fulvestrant on Overall Survival in Hormone Receptor-Positive, ERBB2-Negative Breast Cancer That Progressed on Endocrine Therapy- MONARCH2. JAMA Oncol. 2020 Jan; 6(1): 116-124. doi: 10.1001/jamaoncol.2019.4782. PMID: 31563959

Raffield LM, Lu AT, Szeto MD, Little A, Grinde KE, Shaw J, Auer PL, Cushman M, Horvath S, Irvin MR, Lange EM, Lange LA, Nickerson DA, Thornton TA, Wilson JG, Wheeler MM, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology & Hemostasis Working Group, Zakai NA, Reiner AP. Coagulation factor VIII: Relationship to cardiovascular disease risk and whole genome sequence and epigenome-wide analysis African Americans. J Thromb Haemost. 2020 Jan 27. doi: 10.1111/jth.14741. PMID: 31985870

Tang W, Stimson MR, Basu S, Heckbert SR, Cushman M, Pankow JS, Folsom AR, Pankratz N. Burden of rare exome sequence variants in PROC gene is associated with venous thromboembolism: a population-based study. J Thromb Haemost 2020 Feb;18:445-53. PMID: 31680443

Plante T, Cushman M, Choosing color palettes in scientific figures. Res Pract Thromb Haemost 2020;4:176-80. Res Pract Thromb Haemost. 2020 Feb 17;4(2):176-180. doi: 10.1002/rth2.12308. PMID: 32110746

George TJ, Manochakian R, Wood M, Polansky M, Baer A, Grupe A, Shyr Y, Wang C, Wil- liams J, Horn L. Quantitative Analysis of Oncology Professional Learning Preferences. JCO On- col Pract. 2020 Feb:16(2):e155-e165. doi: 10.1200/JOP.18.00731. PMID: 32045553

Cortes J, Perez-Garcia JM, Llombart-Cussac A, Curigliano G, El Saghir NS, Cardos F, Barriios CH, Wagle S, Roman J, Harbeck N, Eniu A, Kaufman PA, Tabernero J, Garcia-Estevez L, Schmid P, Arribas J. Enhancing global access to cancer medicines. CA Cancer J Clin. 2020 Feb 18. doi: 10.3322/caac.21597. PMID: 32068901

Tripathy D, Brufsky A, Cobleigh M, Jahanzeb M, Kaufman PA, Mason G, O’Shaughnessy J, Rugo HS, Swain SM, Yardley DA, Chu L, Li H, Antao V, Hurvitz SA. De Novo Versus Recur- rent HER2-Positive Metastatic Breast Cancer: Patient Characteristics, Treatment, and Survival from the SystHERs Registry. Oncologist. 2020 Feb;25(2):e214-e222. doi: 10.1634/theoncologist.2019-0446. PMID: 32043771

Kaufman PA, Toi M, Neven P, Sohn J, Grischke EM, Andre V, Stoffregen C, Shekarriz S, Price GL, Carter GC, Sledge GW Jr. Health-Related Quality of Life in MONARCH 2: Abemaciclib

98 plus Fulvestrant in Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer after Endocrine Therapy. Oncologist. 2020 Feb;25(2):e243-e251. doi: 10.1634/theoncologist.2019- 0551. PMID: 32043763

Ng HK, Rogala BG, Ades S, Schwartz JR, Ashikaga T, Holmes CE. Prospective evaluation of drug-drug interactions in ambulatory cancer patients initiated on prophylactic anticoagulation. J Oncol Pharm Pract. 2020 Feb 11:1078155220901569. doi: 10.1177/1078155220901569. PMID: 32046579

Jehangir W, Karabachev A, Jahangir T, Umyarova E. Myelodysplastic Syndrome with Transfu- sion Dependence Treated with Venetoclax. Case Rep Hematol. 2020 Mar 12;2020:9031067. doi: 10.1155/2020/9031067. PMID: 32231817

Chi G, Cushman M. Attention and citation: common interests of researchers and journals. Res Pract Thromb Haemost. 2020 Mar;4(3):353-356. doi: 10.1002/rth2.12322. PMID: 32211569

Cobleigh M, Yardley DA, Brufsky AM, Rugo HS, Swain SM, Kaufman PA, Tripathy D, Hurvitz SA, O’Shaughnessy J, Mason G, Antao V, Li H, Chu L, Jahanzeb M. Baseline Charac- teristics, Treatment Patterns, and Outcomes in Patients with HER2-Postive Metastatic Breast Cancer by Hormone Receptor Status from SystHERs. Clin Canc Res. 2020 Mar 1;26(5):1105- 1113. doi:10.1158/1078-0432.CCR-19-2350. PMID: 31772121

Cortes J, Perez-Garcia JM, Llombart-Cussac A, Curigliano G, El Saghir NS, Cardoso F, Barrios CH, Wagle S, Roman J, Harbeck N, Eniu A, Kaufman PA, Tabernero J, Garcia-Estevez L, Schmid P, Arribas J. Enhancing Global Access to Cancer Medicine. CA Cancer J Clin. 2020 Mar;7(2):105-124. doi: 10.3322/caac.21597. PMID: 32068901

Houghton DE, Koh I, Ellis A, Key NS, Douce DR, Howard G, Cushman M, Safford M, Zakai NA. Hemoglobin Levels and Coronary Heart Disease Risk by Age, Race and Sex in the Reasons for Geographic and Racial Differences in Stroke Study (REGARDS). Am J Hematol 2020 Mar; 95(3):258-266. doi: 10.1002/ajh.25703. PMID: 31840854

Folsom AR, Wang W, Parikh R, Lutsey PL, Beckman JD, Cushman M. Hematocrit and incidence of venous thromboembolism. Atherosclerosis Risk in Communities (ARIC) Study Investi- gators. Res Pract Thromb Haemost 2020 Mar 11;4(3):422-428. doi: 10.1002/rth2.12325. eCol- lection 2020 Mar. PMID: 32211576

Olson NC, Koh I, Reiner AP, Judd SE, Irvin MR, Howard G, Zakai NA, Cushman M. Soluble CD14, ischemic stroke, and coronary heart disease risk in prospective study: the REGARDS cohort. J Am Heart Assoc 2020 Mar 17:9(6):e014241. doi: 10.1161/JAHA.119.014241. PMID: 32157955

Cushman M. Publishing in the COVID Era. Res Pract Thromb Haemost 2020 Apr 16;4(4):438. doi: 10.1002/rth2.12341. PMID: 32548545

Holmes CE, Ades S, Gilchrist S, Douce D, Libby K, Rogala B, Parenteau E, Cushman M, Holm AK., et al. Successful Model for Guideline Implementation to Prevent Cancer-Associated Thrombosis: Venous Thromboembolism Prevention in the Ambulatory Cancer Clinic. JCO Oncol Pract. 2020 Apr 8:JOP1900697. doi: 10.1200/JOP.19.00697. PMID: 32267798

Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, Nigoghossian C, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Giri J, Cushman M, Quere I, Dimakakos EP, Gibson CM, Lippi G, Favalora EJ, Fareed J, Caprini JA, Tafur AJ, Burton JR, Francese DP, Wang EY, Falaga A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Steg PG, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstandinides SV, Weitz JI, Lip GYH, Bikdeli B, et al. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, An- tithrombotic Therapy, and Follow-up. J Am Coll Cardiol, 2020 Apr 15:S0735-1097(20)35008-7. doi: 10.1016/j.jacc.2020.04.031. PMID: 32311448

Neumann I, Izcovich A, Zhang Y, Rada G, Kahn SR, Spencer F, Rezende S, Dentali F, Bauer K, Morgano GP, Yepes-Nuñez JJ, Nieuwlaat R, Wiercioch W, Lu L, Wu J, Cushman M, Schune- mann H. DOACs vs LMWHs in hospitalized medical patients: a systematic review and meta- analysis that informed 2018 ASH guidelines. Blood Adv 2020 Apr 14:4(7):1512-1517. doi: 10.1182/bloodadvances 2019000840 PMID: 32289163

Leavitt C, Zakai NA, Auer P, Cushman M, Lange EM, Levitan EB, Olson N, Thornton TA, Tracy RP, Wilson JG, Lange LA, Reiner AP, Raffield LM. Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans. PLoS One. 2020 Apr 2;15(4):e0231013. doi: 10.1371/journal.pone.0231013. PMID: 32240245

Bakhshi H, Varadarajan V, Ambale-Venkatesh B, Meyghani Z, Ostovaneh MR, Durda P, Wu CO, Tracy RP, Cushman M, Bluemke DA, Lima JAC. Association of soluble interleukin-2 receptor α and tumour necrosis factor receptor 1 with heart failure: The Multi-Ethnic Study of Ath- erosclerosis. ESC Heart Fail 2020 Apr:;7(2):639-644. doi: 10.1002/ehf2.12623. PMID: 32155316

Sawano M, Yuan Y, Kohsaka S, Inohara T, Suzuki T, Okamura T, Howard G, Howard VJ, Judd S, Soliman EZ, Cushman M. Electrocardiographic ST-T abnormities are associated with stroke risk in the REGARDS Study. Stroke 2020 Apr:51(4):1100-1106. doi: 10.1161/STROKEAHA.119.028069. PMID: 32126939

Swain SM, Miles D, Kim SB, Im YH, Im SA, Semiglazor V, Ciruelos E, Schneeweiss A, Loi S, Monturus E, Clark E, Knott A, Restuccia E, Benyunes MC, Cortes J, CLEOPATRA study group (Kaufman PA was part of the CLEOPATRA study group) Pertuzumab, trastuzumab, and docet- axel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomized, placebo-controlled, phase 3 study. Lancet Oncol. 2020 Apr;21(4):519-530. doi: 10.1016/S1470-2045(19)30863-0. PMID: 32171426

Toth MJ, Voigt TB, Tourville TW, Prior SM, Guigni BA, Schlosberg AV, Smith IB, Forest TJ, Kaufman PA, Wood ME, Rehman H, Dittus K. Effect of neuromuscular electrical stimulation

100 on skeletal muscle size and function in patients with breast cancer receiving chemotherapy. J Appl Physiol (1985) 2020 May 7. doi:10.1152/japplphysiol.00203.2020. PMID: 32378975

Darzi AJ, Karam SG, Charide R, Etxeandia-Ikobaltzeta I, Cushman M, Gould MK, Mbuagbaw L, Spencer FA, Spyropoulos AC, Streiff MB, Woller S, Zakai NA, Germini F, Rigoni M, Agarwal A, Morsi RZ, Iorio A, Akl EA, Schünemann HJ, Darzi AJ, et al. Prognostic factors for VTE and bleeding in hospitalized medical patients: a systemic review and meta-analysis. Blood. 2020 May 14: 135(20):1788-1810. doi: 10.1182/blood.2019003603. PMID: 32092132

Sarfo FS, Akinyemi R, Howard G, Howard VJ, Wahab K, Cushman M, Levine DA, Ogunniyi A, Unverzagt F, Owolabi M, Obviagele B. Vascular brain Injury Progression after Stroke (VIPS) study: concept for understanding racial and geographic determinants of cognitive function decline after stroke. J Neurol Sci 2020 May 15:412:116754. doi: 10.1016/j.jns.2020.116754. PMID: 32120131

Tabb L, Ortiz AG, Judd SE, Cushman M, McClure LA. Exploring the spatial patterning in racial differences in cardiovascular health between blacks and whites across the United States: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. J Am Heart Assoc 2020 May 5-9(9):e016556. doi: 10.1161/JAHA.120.016556. PMID: 32340528

Wiercioch W, Nieuwlaat R, Akl EA, Kunkle R, Alexander KE, Cuker A, Rajasekhar A, Alonso- Coello P, Anderson DR, Bates SM, Cushman M, Dahm P, Guyatt G, Iorio A, Lim W, Lyman GH, Middeldorp S, Monagle P, Mustafa RA, Neumann I, Ortel TL, Rochwerg B, Santesso N, Vesely SK, Witt DM, Schünemann HJ. Methodology for the American Society of Hematology VTE guidelines: current best practice, innovations and experiences. Blood Adv 2020 May 26;4(10):2351-2365. doi: 10.1182/bloodadvances.2020001768. PMID: 32453843

Darzi AJ, Karam SG, Spencer FA, Spyropoulos AC, Mbuagbaw L, Woller SC, Zakai NA, Streiff MB, Gould MK, Cushman M, Charide R, Etxeandia-Ikobaltzeta I, Germini F, Rigoni M, Agarwal A, Morsi RZ, Akl EA, Iorio A, Schunemann HJ. Risk models for VTE and bleeding in medical inpatients: systematic identification and expert assessment. Blood Adv. Jun 23; 4(12): 2557-2566. doi: 10.1182/bloodadvances.2020001937. PMID: 32542391

Gilchrist SC, Howard VJ, Akinyemiju T, Judd SE, Cushman M, Hooker SP, Diaz KM. Associa- tion of Sedentary Behavior With Cancer Mortality in Middle-aged and Older US Adults. JAMA Oncol. 2020 Jun 18. doi: 10.1001/jamaoncol.2020.2045. PMID: 32556069

Akinyemiju T, Wilson LE, Deveaux A, Aslibekyan S, Cushman M, Gilchrist S, Safford M, Judd S, Howard V. Association of Allostatic Load with All-Cause and Cancer Mortality by Race and Body Mass Index in the REGARDS Cohort. Cancers (Basel). 2020 Jun 26;12(6) pii. E1695. doi: 10.3390/cancers/2061695. PMID: 32604717

Roth DL, Haley WE, Sheehan OC, Huang J, Rhodes JD, Durda P, Howard VJ, Walston JD, Cushman M. The transition to family caregiving and its effect on biomarkers of inflammation. Proc Natl Acad Sci USA. 2020 Jun 24. pii: 202000792. doi: 10.1073/pnas.2000792117. PMID: 32581123

101

Adrianzen-Herrera D, Choudhary G, Gordon-Mitchell S, Ramachandra N, Bhagat T, Zhang H, Aluri S, Shastri A, Steidl U, Will B, Yang WL, Mahler M, Eichenbaum G, Guha C, Verma A. The thrombopoietin mimetic JNJ-26366821 increases megakaryopoiesis without affecting malignant myeloid proliferation. Leuk Lymphoma. 2020 Jun 24;1-13. doi: 10.1080/10428194.2020.1775213. PMID: 32578476

Landry KK, Judd SE, Kleindorfer DO, Howard G, Howard VJ, Zakai NA, Cushman M. N-Ter- minal pro-B-type natriuretic peptide and stroke risk across a spectrum of cerebrovascular disease: The Reasons for Geographic and Racial Differences in Stroke cohort. Res Pract Thromb Haemost. 2020 Jun 14;4(5):893-901. doi: 10.1002/rth2.12365. PMID: 32685900

Landry KK, Wood ME. Panel testing for hereditary breast cancer: More of less? Current Breast Cancer Reports. Curr Breast Cancer Rep 2020 June (12):45–50.

102

Division of Hospital Medicine: Update for July 1, 2019 - June 30, 2020 Chief: Mark E. Pasanen, MD, FACP

The Division of Hospital Medicine at the Larner College of Medicine at the University of Vermont pursues excellence in academic Hospital Medicine by:  Delivering compassionate, responsive, integrated care to medical inpatients 24 hours a day  Teaching the science, art, and joy of medicine to students, trainees, and colleagues  Promoting knowledge through research and educational efforts  Cultivating a collegial and sustainable practice environment  Collaborating with members of the hospital and university community to improve the quality, safety and value of inpatient care

Our Hospitalist faculty physicians are involved in all aspects of the academic teaching hospital mission, including providing valuable clinical services, teaching a broad range of learners, engaging in leadership and system improvement while advancing a broad research agenda.

Service: The Internal Medicine Hospitalist Service specializes in the diagnosis and treatment of hospitalized adults, both as the primary service and in the role of consultant – with our service providing 24x7 attending coverage. We serve as physician leadership for the Rapid Re- sponse Team, which responds to inpatients with medical emergencies throughout the hospital. Our Hospitalists work in multi-disciplinary teams to provide effective, safe, timely and patient-centered care. We also offer medical consultation to patients in the inpatient Acute Rehabilitation program. The Adult Hospital Medicine service includes 4 General Internal Medicine teaching services (each with an attending, 3 residents and 3rd and 4th year students), 1 Family Medicine teaching service (mix of FM and IM attendings with 3 FM residents), 3 non-resident services (each staffed by an attending and physician assistant), a medicine consult service, a triage attending, and a Medical Oncology service, which works closely with Oncology to provide inpatient care to patients with solid tumors. In addition, at night we have 2 nocturnists (and intermittent physician assistant coverage), who provide cross-coverage care and perform admissions for both the teaching and non-resident Adult Hospital Medicine services along with Medical Consults, rapid response coverage and outside hospital triage. We continue to expand our use and teaching of bedside ultrasound techniques under the expert guidance of Drs. Mohit Jindal and Tara Scribner, both of whom achieved UVMMC ultrasound privileges this past year. Evidence of strong clinical performance includes a low overall re-admission rate of <5%. The Internal Medicine Hospitalist Service faculty had a very busy year, which included preparing for and caring for potential and confirmed COVID-19 patients.

103

Our Hospitalists have been engaged in numerous institutional quality improvement and safety initiatives. Our most recent successful project focused on training all faculty in Im- provement Science methodology. In the last few years, we have also significantly reduced the rate of hyperglycemia, reduced the number of unnecessary labs performed on our inpatients, improved the completion of accurate problem lists at the time of discharge, improved communication with primary care at discharge and decreased the wait time of orders for patients admitted through the Emergency Department. We are currently engaged in work to improve the use of prophylaxis in the prevention of venous thromboembolism.

Education: Our faculty teaches General Internal Medicine and Hospital Medicine to medical students, resident physicians, professional colleagues, and community members.

Hospitalists serve as the teaching attending for the four General Medicine teaching teams and the Medical Oncol- ogy team throughout the year – offering clinical supervision, bedside and didactic education, along with feedback and evaluation to resident physicians and medical students. At night, our Nocturnists provided supervision and education for our night residents. Additionally, our inpatient faculty physicians lead the Medicine Consult elective for residents and medical students, which includes residents from Orthopedic Surgery.

Our faculty are regular participants and facilitators at Resident Report and Intern Report. Dr. Amy Teleron has provided outstanding leadership in our Adult Code training for our residents, with a focus on team dynamics and communication – resulting in recognized improvement in code performance. Through the leadership of Dr. Jason Bartsch, we have developed the Hospital Medicine academic half-day curriculum – in which multiple hospitalists participate. Several of our faculty also serve as preceptors for the Internal Medicine Resident Clinic. Drs. Allen Repp, Preetika Muthukrishnan and Maria Burnett, along with Amanda Kennedy, PharmD, have developed an incredibly robust and effective Improvement Science curriculum. Amanda Kennedy also oversees our comprehensive Internal Medicine Resident research program. In addition, Drs. David Rand, Lee-Anna Burgess, Rachel McEntee and Naomi Hodde have been developing and delivering teaching in communication skills.

Dr. Mark Pasanen and Dr. Shaden Eldakar-Hein serve as the Program Director and Associate Program Director for the Internal Medicine Residency, respectively. Our faculty members have been recognized numerous times by the resident physicians for teaching excellence. Most recently, Dr. Lee-Anna Burgess received the Mark A. Levine Award for Outstanding Teacher of the Year in General Internal Medicine in 2020.

At the UVM College of Medicine, our primary teaching is in the hospital setting, focusing on the Internal Medicine Inpatient Clerkship, Internal Medicine Acting Internship and the Clinical Tutor program (which is directed by one of our Hospitalists, Dr. Bartsch). Dr. Bartsch also serves as Assistant Clerkship Director and serves on the Active Learning Advisory Committee. Dr. Burgess serves as Assistant Acting Internship Director. Our faculty are also involved in other teaching activities including Foundations courses, Convergence and Professionalism, Communica- tion and Reflection. In recognition of her commitment to students, Dr. Eldakar-Hein serves as the Interim Assistant Dean of Students, and was awarded with the AOA Society Faculty Award. She also serves as Faculty Advisor for the Committee on Advancement and for the Social Justice Coalition.

We educate our colleagues locally, regionally and nationally in a variety of venues. This includes successfully delivery of our 9th annual University of Vermont Continuing Medical Education Course in Hospital Medicine, attracting a national audience and with faculty largely from the Division of Hospital Medicine and other divisions of the Depart- ment of Medicine. Drs. Carrie Lyon, Steve Grant and Jason Bartsch co-direct this extremely popular course. In addition, Dr. Shea Lambirth co-directed the University of Kentucky Rural Physician Leadership Faculty Development Conference in November 2019.

104

The Internal Medicine Hospitalist Service faculty are also very involved in mentorship and advising. This includes advising numerous medical students on career choice and residency match issues. Residents also frequently seek out our Hospitalists to serve as advisors, especially those going into the growing field of Hospital Medicine. Dr. Shaden Eldakar-Hein is the Specialty Advisor for Internal Medicine for Larner medical students.

Research: In addition to our clinical work and focus on quality and safety, we have diverse scholarly interests among our faculty. This has included externally funded clinical trials of immunizations and high value laboratory ordering practices. In addition, internal funding has supported work on teaching trainees to facilitate code status discussions. Previous funding has supported work on teamwork with a focus on communication during rapid response calls. Other areas of interest include opioid-related adverse events in inpatients, interosseus access by EMTs prior to hospitalization, adult code communication and performance and VTE prevention in acute medically ill patients.

Leadership: The Internal Medicine Hospitalist Service faculty members are extensively engaged in service at the national, state and institutional levels. National and regional involvement includes the OneCare Vermont Clinical Advisory Board, Vermont Chapter for the American College of Physicians (past Governor and current Governor, along with 3 members of the advisory council membership) and past president of the UVM Medical Alumni Executive Committee. Dr. Repp serves on the Society of Hospital Medicine Performance Measurement and Reporting Committee, the Ver- mont Medical Society Council and the 2019 Overall Hospital Quality Star Ratings Provider Leadership Work Group for the Centers of Medicare and Medicaid Services.

Faculty participation in committees and task forces at the Larner College of Medicine and the University of Ver- mont Medical Center is also wide-ranging. Highlights include leadership and/or participation on the Tenure and Promotions committee, Committee for Advancement, Rapid Response and Resuscitation committee, Unit-based Care leadership Operations/Workforce, Quality Improvement, Ethics, COVID-19 response committees and EPIC/IT. In addition, we have had active engagement in the Network Adult Hospital Medicine Specialty Council.

There are numerous specific examples of leadership within the faculty. Dr. Steven Grant serves as the Associate Chief Medical Officer for Care Coordination and Patient Transitions. Drs. Chad Mitchell, Mohit Jindal and Steve Grant serve a critical role in Utilization Review, providing real-time reviews in coordination with Case Manage- ment. Dr. Rachel McEntee has been instrumental in helping to optimize EPIC, our electronic health record, through her work and leadership as a Physician Informaticist. Dr. Amy Teleron has provided leadership in significantly improving our Rapid Response and Resuscitation training and implementation and served as Assistant Director of the COVID-19 Incident Command Biologic Branch. Dr. Repp serves as Vice Chair of Quality for the Department of Medi- cine. Drs. Pasanen and Eldakar-Hein serve respectively as the Internal Medicine Residency Program Director and Associate Program Director. Dr. Eladakar-Hein also serves as Interim Assistant Dean of Students for Larner College of Medicine. Drs. Bartsch and Burgess respectively serve as Assistant Director for the Medicine clerkship and Acting Internship.

We have worked closely with other departments in an effort to optimize patient care. This has included Co-Man- agement services with the Orthopedics Hip Fracture and Spine Service. We have also developed a shared model of care with the Renal Transplant Service and Ophthalmology. In addition, Drs. Gardner, Muthukrishnan and Rand serve as Unit-Based Leaders for our General Medical and Oncology units.

Faculty/Members of the Division of Hospital Medicine:

Jason Bartsch, MD Assistant Professor of Medicine Director of Medical Education, Division of Hospital Medicine Assistant Clerkship Director, Department of Medicine

Brittany Bryan, PA

105

Lee-Anna Burgess, MD Assistant Professor of Medicine Assistant Acting Internship Director, Department of Medicine

Maria Burnett, MD, MS Assistant Professor of Medicine Co-Director of Quality and Safety, Division of Hospital Medicine

Caleb Burr, MD Assistant Professor of Medicine

Alejandro Castro, MD Assistant Professor of Medicine

Markus Degirmenci, MD Assistant Professor of Medicine

Elie Donath, MD Assistant Professor of Medicine

Shaden Eldakar-Hein, MD, MS Associate Professor of Medicine Associate Program Director, Internal Medicine Residency Interim Assistant Dean of Students, Larner College of Medicine

Florian Foerg, MD Assistant Professor of Medicine Director, Hospital Medicine Consult and Co-management Service

Jon Ford, PA

Melanie Fortin, PA

Zechariah Gardner, MD Assistant Professor of Medicine Director for Baird 3 Unit-based Care

Steven Grant, MD Associate Professor of Medicine Associate Director, Hospitalist Service Associate Chief Medical Officer for Care Coordination and Patient Transitions

Sonali Herath, PA

Naomi Hodde, MD Assistant Professor of Medicine

Mohit Jindal, MD Assistant Professor of Medicine Director of Ultrasound Education, Division of Hospital Medicine

Amanda Kennedy, PharmD

106

Associate Professor of Medicine Chair, Internal Medicine Residency Research Committee Department of Medicine Quality Scholar

Erin Kurek, MD, MPH Assistant Professor of Medicine

Shea Lambirth, MD Assistant Professor of Medicine

Griffin Latulippe, PA

Caroline Lyon, MD, MPH Associate Professor of Medicine Director, Hospital Medicine CME course

Rachel McEntee, MD Assistant Professor of Medicine Informaticist

Sadie Mills, MD Assistant Professor of Medicine

Chad Mitchell, MD Assistant Professor of Medicine

Preetika Muthukrishnan, MD Assistant Professor of Medicine Co-Director of Quality and Safety, Division of Hospital Medicine Co-director for McClure 6 Unit-based Care

Melissa Naef, PA

Mark Pasanen, MD Associate Professor of Medicine Program Director, Internal Medicine Residency Program Chief, Division of Hospital Medicine

David Rand, DO Assistant Professor of Medicine Co-director for Miller 5 Unit-based Care

Allen Repp, MD, MS Professor of Medicine Vice-Chair for Quality, Department of Medicine

Tara Scribner, MD Assistant Professor of Medicine

Paul Slavik, MD Assistant Professor of Medicine

Michael Stutzman, MD

107

Assistant Professor of Medicine

Amy Lynn Teleron, MD Assistant Professor of Medicine Medical Director, Clinical Emergency Response Team Medical Director Emergency Response Nurse Team

Eric Westphal, PA

Dennis Woods, MD Assistant Professor of Medicine

Editorships and Editorial Boards:

Allen Repp, MD, MS Reviewer:  Journal of Hospital Medicine  Journal for Healthcare Quality  Journal of General Internal Medicine  Academic Medicine  The Joint Commission Journal on Quality and Patient Safety

Zech Gardner, MD Reviewer:  British Medical Journal Open Quality

Major Faculty Awards:

Lee-Anna Burgess, MD was the recipient of the Mark A. Levine, M.D. Award for Outstanding Teacher of the Year in General Internal Medicine

Shaden Eldakar-Hein, MD, MS was the recipient of the Alpha Omega Alpha Society Faculty Award

Publications – peer reviewed, chapters, etc. (not abstracts)

Lozier MR, Sanchez AM, Lee JJ, Donath E, Font VE, Escolar E. Thromboembolic Outcomes of Dif- ferent Anticoagulation Strategies for Patients with Atrial Fibrillation in the Setting of Hyper- trophic Cardiomyopathy: A Systematic Review. J Atr Fibrillation. 2019 Dec 31;12(4):2207.

Pino JE, Shah V, Ramos Tuarez FJ, Kreidieh OI, Donath E, Lovitz LS, Rothenberg M, Cubeddu RJ, Nores ME, Chait. The utility of pulmonary function testing in the preoperative risk stratification of patients undergoing transcatheter aortic valve replacement. Catheter Cardiovasc Interv. 2020 May 1;95(6):E179-E185.

Lozier MR, Pachon RE, Lee JJ, Sanchez AM, Donath E, Osman AF. Long-term clinical outcomes and prognostic indicators for focal impulse and rotor modulation guided ablation: A single-center observational study. J Electrocardiol. 2020 Jun 18;61:153-159.

108

Grajeda Silvestri ER, Pino JE, Donath E, Torres P, Chait R, Ghumman. Impella to unload the left ventricle in patients undergoing venoarterial extracorporeal membrane oxygenation for cardiogenic shock: A systematic review and meta-analysis. J Card Surg. 2020 Jun;35(6):1237-1242.

Armstrong PW, Pieske B, Anstrom KJ, Ezekowitz J, Hernandez AF, Butler J, Lam CSP, Ponikowski P, Voors AA, Jia G, McNulty SE, Patel MJ, Roessig L, Koglin J, O'Connor CM; VICTORIA Study Group (Donath E). Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2020 May 14;382(20):1883-1893.

Bartlett KJ, Vo AP, Rueckert J, Wojewoda C, Steckel EH, Stinnett-Donnelly J, Repp AB. Promoting appropriate utili- sation of laboratory tests for inflammation at an academic medical centre. BMJ Open Qual. 2020 Feb;9(1).

Kennedy AG, Burnett M, Muthukrishnan P, Sobel H, van Eeghen C, Repp AB. “I think I was losing the forest for the trees:” Evaluation of an Internal Medicine residency Quality Improvement curriculum. Medical Science Edu- cator. First online 15 Nov 2019.

Sacco AY, Self QR, Worswick EL, Couperus CJ, Kolli SS, Muñoz SA, Carney JK, Repp AB. Patients' Perspectives of Di- agnostic Error: A Qualitative Study. J Patient Saf. 2020 Mar 11. van Eeghen C, Kennedy AG, Pasanen ME, MacLean CD. A new quality improvement toolkit to improve opioid prescribing in primary care. J Am Board Fam Med. 2020 Jan;33(1):17-26.

Sobel HG, Goedde M, Maruti S, Hadley-Strout E, Wahlberg E, Kennedy AG. Primary care residents delivering care: integration of office-based opioid treatment into an Internal Medicine residency curriculum. Acad Psychiatry. 2019 Oct;43(5):499-502. van Eeghen C, Edwards M, Libman BS, MacLean CD, Kennedy AG. Order from chaos: An initiative to improve opioid prescribing in rheumatology using Lean A3. ACR Open Rheumatol. 2019 Sep 4;1(9):546-551.

Tarleton EK, Kennedy AG, Rose GL, Crocker A, Littenberg B. Association between depression and serum magnesium levels in an adult primary care population. Nutrients. 2019 Jul;11(7):1475.

Hossain M, Islam K, Kelly M, Mayo Smith LM, Charles RC, Weil AA, Bhuiyan TR, Kováč P, Xu P, Calderwood SB, Si- mon JK, Chen WH, Lock M, Lyon CE, Kirkpatrick BD, Cohen M, Levine MM, Gurwith M, Leung DT, Azman AS, Harris JB, Qadri F, Ryan ET.Immune responses to O-specific polysaccharide (OSP) in North American adults infected with Vibrio cholerae O1 Inaba. PLoS Negl Trop Dis. 2019;13(11):e0007874.

Presentations:

Department of Medicine Quality Showcase (May 8, 2020)

Steinmetz-Wood S, Anderson E, Wall A, Zimmer J, Bergeron J, Bolton KC, Depo B, Neuwirth J, Desautels A, Leahy K, Purcell K, Burnett M, Muthukrishnan P, Van Eeghen C, Kennedy AG Transitions of Care at Hospi- tal Discharge - To call or not to call?

109

Depo B, Gervais M, Gwilliam C, Khan S, McPherson E, Mahurin C, Parker J, Qin K, Burnett M, Muthukrish- nan P, van Eeghen C, Kennedy AG, Desautels A, Leahy K, Purcell K. Standardizing "Clinical Issues Needing Follow-up" to Improve Discharge Communication

Constance van Eeghen, DrPH, MHSA, MBA, Elizabeth Wahlberg, MD, Amanda G. Kennedy, PharmD, BCPS.

Effects of Nostalgia-Directed Music Therapy on Residents with Dementia Garrett Chan1, Jack Fitzsimons, Sidika Kajtezovic, Kristen Keene, Marc Kostrubiak, Jessica Sikka, John Vandenberge, Cameron Segal, Shaden Eldakar- Hein, MD, MS, Michael Stutzman, MD and Jan K. Carney, MD, MPH presented at APHA's Annual Meeting and Expo (November 2019)

UVM Hospital Medicine Conference (Feb 2020)

Paul Slavik: “Choosing Wisely: Things We Do For No Reason” Naomi Hodde: “Medical Oncology Update” Allen Repp: “On Safari: Zebras and Other Rare Sightings in Vermont David Rand: “Inpatient Palliative Care” Caroline Lyon: “Quick Hits: Updates in Consult Medicine” Preetika Muthukrishnan: “Quality and Safety in Hospital Medicine Practice” Jason Bartsch (Closing Address): “Resilience”

Rising Together: Working with Compassion and Purpose (UVMHN Summit 11/22/19)

Jason Bartsch presented personal reflections

110

Division of Immunobiology Ralph Budd, MD, Director http://www.med.uvm.edu /medicine/immunobiology http://www.med.uvm.edu/vciid

The Division of Immunobiology currently has five research faculty and two graduate students. Research covers a variety of areas, including the immune response to infections and vaccines, virus-host interactions, autoimmune mechanisms, and inflammation in cancer. Research support includes numerous individuals grants as well as a Center of Biomedical Research Excellence (COBRE) Award from NIH. Now in its 14th year, the COBRE grant supports the activities of the Vermont Center for Immunology and Infectious Diseases (VCIID), which now numbers 25 faculty in 8 departments in 3 colleges and is in close alliance with the Vaccine Testing Center. The VCIID has a weekly joint Research-in-Progress meeting, seminar series, and a journal club. This provides a regular forum for students and postdoctoral fellows to present their research progress as well as for faculty to review hypotheses and specific aims of planned grants. During the first 10 years of COBRE funding, VCIID faculty published 419 articles and received over $92 million in funding. This also provided funds to allow the College of Medicine to build a new BSL3 facility in partnership with the Vermont Department of Health, and to recruit new faculty to the theme of the host response to infection. We also have a T32 Training Grant from NIH, also in its 14th year, to support the salaries of our graduate students.

Faculty

Ralph Budd, MD University Distinguished Professor of Medicine and Microbiology & Molecular Genetics Director, Vermont Center of Immunology & Infectious Diseases  Key Research Interests: Autoimmune mechanisms, immune cell death, Lyme arthritis, caspase regulation, immune metabolism  Clinical interests in autoimmune diseases

Jason Botten, PhD Associate Professor of Medicine, Adjunct in Microbiology and Molecular Genetics  Key Research Interests: Identification of key virus-host interactions required for viruses (e.g. arenaviruses, flaviviruses, coronaviruses hantaviruses) to complete their life cycle and/or cause human disease; understanding how host-driven posttranslational modifications (e.g. phosphorylation) of viral proteins regulate their functionality; understanding the natural history of host T and B cell responses to virus infection and how these immune cells contribute to protective immunity or immune-mediated pathogenesis; viral diagnostics; translating our basic science discoveries into vaccines and therapeutics. Emily Bruce, PhD Faculty Scientist  Key Research Interests: Understanding how viruses (arenaviruses, hantaviruses, influenza virus, coronaviruses) interact with host cellular machinery to facilitate virus particle assembly and release and the identification of neutralizing antibodies against these viruses.

Cory Teuscher, PhD Professor of Medicine and Pathology  Key Research Interests: Genetics of animal models of autoimmune and infectious disease

111

Tina Thornton, PhD Assistant Professor of Medicine  Key Research Interests: Understanding the interactions of signaling pathways that control early thymo- cyte development and survival, the interaction of the p38 MAPK pathway and GSK3 in the context of DNA damage signaling.

Graduate Students, Post-doctoral Fellows, MD PhD Students and brief statement on their research study:

Annalis Norman (graduate student) – Identification of human monoclonal antibodies for treatment of hantavirus and COVID-19 disease in humans; identification of key host proteins required for arenavirus propagation.

Inessa Manuelyan (graduate student) – Identification of key human proteins and host-drive post-translational modifications of viral proteins required for flavivirus and coronavirus propagation.

Editorships and Editorial Boards:

(Budd) Senior Editor for “Textbook of Rheumatology” 11th Edition, Elsevier

(Botten) Editor for Frontiers in Microbiology

Study Sections and Federal Advisory Boards:

Budd: 2019 Arthritis Connective Tissue Sciences (ACTS) NIH Study Section 2020 T32 Grant Reviews AITC NIAID 2020 NIH Immunity and Host Defense 2020 ZGM1 RCB-9 COBRE Phase I Grant Review NIGMS

Botten: 2019 Topics in Drug Discovery, Clinical, and Field Research, ZRG1 IDM-U (02) Special Emphasis Panel, NIH /NIAID, Ad hoc reviewer 2020 Topics in Drug Discovery and Clinical Field Studies (ZRG1 IDM-N (02) Special Emphasis Panel, NIH /NIAID, Ad hoc reviewer

2020 Invitation to review for i) NIH/NIAID Rapid COVID-19 Review Panel, ii) Coronavirus Disease-Immunology (COVID-IMM) peer review panel of the FY20 Peer Reviewed Medical Research Program (PRMRP) for the Depart- ment of Defense Congressionally Directed Medical Research Programs (CDMRP), iii) 2020 PAR-20-177 and PAR-20- 178, “Emergency Awards: Rapid Investigation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19) (R21/R01 Clinical Trial Not Allowed)”, and iv) NIH Topics in Drug Discov- ery, Clinical, and Field Research in Infectious Diseases.

Teuscher: Ad hoc reviewer for NIH reviewers pool

Permanent member, grant review panel for the National Multiple Sclerosis Society

Major Faculty / Research Awards:

(Budd) U.S. Patent Application No: 15/892,280 “Augmenting the Immune Response by Promoting Cell Death of Immune Cells”. Inventors: Ralph Budd and Cheryl Collins. Issued on June 17, 2019.

112

(Botten) PhD students Inessa Manuelyan and Annalis Whitaker each received travel awards for the 2020 American Society of Virology Meeting. Annalis, Inessa, Emily Bruce, and Dr. Botten all gave talks at this meeting

(Botten) Was a keynote speaker at the 2019 XI International Conference on Hantaviruses meeting in Leuven, Bel- gium and the 2020 International NIH Back to Basics: Research to Address Bunyavirales Emergence Workshop in Rockville, MD.

(Botten) Was the Opponent for Drs. Gary Kobinger and David Safronetz’s PhD student Bryce Warner at the University of Manitoba, Canada

(Botten) Dr. Botten, former UVM postdoc Dr. Chris Ziegler, and Faculty Scientist Dr. Emily Bruce had one of their images featured on the cover of their recent publication in Trends in Microbiology.

(Bruce) Selected for oral presentation at the Microbiology Society Annual Conference 2020. ‘Viruses that get under your skin- virus infections of skin and associated epithelia’ session. “Rab proteins play key roles in the mammarenavirus (LCMV) life cycle: from entry to particle formation”. Edinburgh, UK. March 31-April 3, 2020 (Cancelled due to COVID-19).

(Bruce) Selected for oral presentation at the American Society for Virology 39th Annual Meeting. Oral presentation, ‘Bunyaviruses & Arenaviruses: Host Response’ workship. "Rab proteins play key roles in the mammarenavirus (LCMV) life cycle: from entry to particle formation". Fort Collins, Colorado, USA. June 13-17, 2020 (gave talk remotely due to COVID-19).

(Bruce) Invited seminar at MRC-University of Glasgow Centre for Virus Research, Glasgow, UK. March 27, 2020. “Rab proteins play key roles in the mammarenavirus (LCMV) life cycle: from entry to particle formation” (cancelled due to COVID-19).

(Bruce) Invited seminar at the Roslin Institute, University of Edinburgh, UK. March 30, 2020. “Rab proteins play key roles in the mammarenavirus (LCMV) life cycle: from entry to particle formation" (cancelled due to COVID-19).

Grants – list all active by faculty member, PI

Budd: R21 AI 119979 Budd (PI) Title: Metabolic Regulation of Caspases and Survival in T Cells Dates of Award: 04/01/16-09/30/19 Role: PI Current Yr funding: $0 No Cost Extension Source: NIH/NIAID

P30 GM118228 Budd (PI) Title: Vermont Immunology / Infectious Diseases Center Dates of Award: 08/05/2016 – 07/31/21 Role: PI Current Yr funding: $1,165,984 Source: NIH/NIGMS

T32 AI 055402 Budd (PI) Title: Vermont Immunology / Infectious Diseases Training Grant Dates of Award: 09/01/05 – 08/31/21 Role: PI Current Yr funding: $91,231

113

Source: NIH/NIAID

R21 AI 151407 Budd (PI) Title: Ligands for Human Synovial Gamma/Delta T Cells Dates of Award: 04/09/20-03/31/22 Role: PI Current Yr funding: $232,186 Source: NIH/NIAID

Botten:

SPARK2017 (Botten, J.) 2017-2020 SPARK-VT Competition, UVM Title: Therapeutic antibodies for treatment of hantavirus cardiopulmonary syndrome The goal of this award is to develop human monoclonal antibodies for treatment of New World hantavirus disease. Current Yr Funding: $50,000

P30GM118228 (Budd, R.) 08/01/18 - 07/31/19 NIH/NIGMS Centers of Biological Research Excellence (COBRE), Vermont Immunobiology/Infectious Disease Center Dr. Botten is the PI of a pilot project to develop a therapeutic molecule to target ERGIC-53-sensitive viruses Current Yr Funding: $50,000

R41AI132047 (STTR) (Botten, J.) 08/08/2017-07/31/2021 NIH/NIAID Therapeutic antibodies for treatment of hantavirus cardiopulmonary syndrome Major goal is to capture the repertoire of antibodies generated against Andes hantavirus during acute infection and identify those that could be used to therapeutically treat disease. Total award: $599,772

3R41AI132047-01S1 (Supplement to R41AI132047) (Botten, J.) 12/01/2017-07/31/2021 NIH/NIAID Therapeutic antibodies for treatment of hantavirus cardiopulmonary syndrome The major goal of this research supplement is to provide support for Dr. Emily Bruce in my group to reenter the workforce full time and use a novel approach (that is complementary to the approach used in the parent grant) to identify therapeutic antibodies for treatment of hantavirus disease. Total costs with indirect costs: $205,396

R21AI135265 (Botten, J.) 06/01/2018-05/31/2021 NIH/NIAID Title: Mapping the Zika virus phosphoproteome Major goal is to map the phosphorylation sites on the arenavirus proteome and determine which modifications regulate the functionality of arenavirus proteins. Total costs with indirect costs: $425,218

1R43AI142911-01 (SBIR) (Botten, J., Co-PI) 10/01/2018-11/01/2020 NIH/NIAID A novel antibody therapy for Sin Nombre virus infection Major goal is to capture the repertoire of antibodies generated against Sin Nombre hantavirus during acute infection and identify those that could be used to therapeutically treat disease.

114

Total costs: $599,772

SPARK2018 (Botten, J.) 2018-2020 SPARK-VT Competition, UVM Title: Development of monoclonal antibodies for treatment of hantavirus disease in North America The goal of this award is to develop human monoclonal antibodies for treatment of hantavirus disease in North America. Current Yr costs: $50,000

1U01AI141997-01 (Botten, J., Diehl, S., Kirkpatrick, B. MPI) 02/01/19-01/31/24 NIH/NIAID Mechanisms of Protection and Durability for a Live Attenuated Tetravalent Dengue Vaccine Tetravalent dengue vaccination must offer safe and durable protection against all four serotypes of dengue viruses. We leverage four vaccine trials and viral challenges evaluating the NIH dengue vaccine to explore and confirm immune mechanisms associated with protection. Total costs: $3,085,084

OVPR2020 Botten, J. (PI) 2020-2021 Office of the Vice President of Research, UVM COVID-19 Studies The goal of this award is to refocus our lab for COVID-19 studies including development of diagnostics and therapeutics. Total direct costs: $150,000

NASA Botten, J. (PI) 6/01/2020 – 12/31/2020 Screening of novel anti-SARS-CoV-2 peptides for infection of Vero E6 cells with SARS-CoV-2 The overall goal of this project is to evaluate candidate peptides for their ability to inhibit SARS-CoV-2 propagation. Total direct and indirect costs: $100,002

R21AI154198 Botten, J. (PI) 06/01/2020-05/31/2022 NIH/NIAID Deep sequencing the lymphocytic choriomeningitis arenavirus quasispecies to identify and functionally validate the molecular signature of defective interfering particles. Major goal is to identify the genetic identity of LCMV defective interfering genomes. Total direct costs: $275,000 (Total costs with indirect costs: $444,347)

R41AI157527 (STTR) Botten, J., Murad J. (MPI) 09/01/2020-08/31/2022 NIH/NIAID A Novel Broad-spectrum Antiviral Agent Major goal is to develop monoclonal antibodies to ERGIC-53 to make a broad spectrum antiviral for treatment of multiple families of RNA viruses. Direct costs of this subproject: $400,241 (Total costs with indirect costs: $599,560) *we received an impact score of 20 on this STTR grant I (payline is 34 in current year).

Bruce: COBRE Pilot Award. Bruce, E (PI) 08/01/2019-07/29/2020 Role of Rab proteins in standard and defective interfering LCMV particle assembly Awarded from the Vermont Center for Immunology and Infectious Disease COBRE (VCIID) (Ralph Budd, PI) Total direct costs: $50,000

115

COBRE Pilot Award Bruce, E. (PI) 08/01/2020-07/29/2021 Virological and immunological detection of SARS-CoV-2 exposure Awarded from the UVM Translational Global Infectious Disease Research (TGIR) COBRE (Beth Kirkpatrick, PI) Total direct costs: $30,000

Teuscher: R21AI128595 Title: Genome-wide physical mapping of IAV-QTL using wild-derived inbred mice Dates of Award: 12/1/16 – 11/30/2020 Role: PI Current Yr funding: $0 No Cost Extension Source: NIH

Publications – peer reviewed, chapters, etc. (not abstracts):

Bruce EA, Huang ML, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers JW, Jerome KR, Botten JW. Di- rect RT-qPCR Detection of SARS-CoV-2 RNA from Patient Nasopharyngeal Swabs Without an RNA Extraction Step. bioRxiv, 2020 Apr 6;. doi: 10.1101/2020.03.20.001008. PubMed PMID: 32511328; PubMed Central PMCID: PMC7239058.

Bruce, E., King, B., Botten, J. Single molecule FISH for detection and quantitation of arenavirus RNA species. RNA- FISH: Methods and Protocols, a book by Springer Nature. 2020 (In Press)

Collins C, Lui Y, Santos AM, Ballif BA, Gogerly-Moragoda AM, Brouwer H, Ross R, Balagurunathan K, Sharma S, Wright GJ, Davis S, Budd RC. Detection of Cell Surface Ligands for Human Synovial γδ T Cells. J. Immunol. 203:2369- 2376, 2019. PMID 31548331.

Fortner, KA, Blanco, LP, Buskiewicz, I, Huang, N, Gibson, PC, Cook, DL, Pederson, HL, Yuen, PST, Murphy, MP, Perl, A, Kaplan, MJ, and Budd, RC. Targeting Mitochondrial Oxidative Stress with MitoQ Reduces NET Formation and Kidney Disease in Lupus-Prone MRL-lpr Mice. Lupus Sci and Med. 2020;7:e000387. doi:10.1136/lupus-2020- 000387.

Graham, N., Eisenhauer, P., Diehl, S., Pierce, K.K., Whitehead, S.S., Drubin, A.P., Kirkpatrick, B.D., Sette, A., Weiskopf, D., Boyson, J., and Botten, J. Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans. Frontiers in Immunology, 2020;11:479. doi: 10.3389/fimmu.2020.00479. eCollection 2020. PubMed PMID: 32265929; PubMed Central PMCID: PMC7105617

McGill MM, Sabikunnahar B, Fang Q, Teuscher C, Krementsov DN. The sex-specific role of p38 MAP kinase in CNS autoimmunity is regulated by estrogen receptor alpha. J Neuroimmunol. 2020 Mar 4;342:577209. doi: 10.1016/j.jneuroim.2020.577209. Online ahead of print. PMID: 32200131

Pettit SD, Jerome KR, Rouquié D, Mari B, Barbry P, Kanda Y, Matsumoto M, Hester S, Wehmas L, Botten JW, Bruce EA. 'All In': a pragmatic framework for COVID-19 testing and action on a global scale. EMBO Mol Med. 2020 Jun 8;12(6):e12634. doi: 10.15252/emmm.202012634. Epub 2020 May 27. PubMed PMID: 32375201; PubMed Central PMCID: PMC7267598.

116

Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Eisch AR, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM. Erratum: Author Correction: A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease). Commun Biol. 2019 Nov 25;2:439. doi: 10.1038/s42003-019- 0691-0. eCollection 2019. PMID: 31799440

Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Robin Eisch A, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM. A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease). Commun Biol. 2019 Oct 31;2:398. doi: 10.1038/s42003-019-0647-4. eCollection 2019. PMID: 31701027

Secinaro, MA, Fortner, KA, Collins, C, Rincon, M, and Budd, RC. Glycolysis induced MCJ expression that links T cell proliferation with caspase-3 activity and death. Frontiers in Cell and Developmental Biology. 7(28): 1-10, 2019. PMID: 30915331.

Tyler AL, Raza A, Krementsov DN, Case LK, Huang R, Ma RZ, Blankenhorn EP, Teuscher C, Mahoney JM. Network- Based Functional Prediction Augments Genetic Association To Predict Candidate Genes for Histamine Hypersensi- tivity in Mice. G3 (Bethesda). 2019 Dec 3;9(12):4223-4233. doi: 10.1534/g3.119.400740. PMID: 31645420

Ziegler CM, Dang L, Eisenhauer P, Kelly JA, King BR, Klaus JP, Manuelyan I, Mattice EB, Shirley DJ, Weir ME, Bruce EA, Ballif BA, Botten J. NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z. PLoS Pathogens, 2019 Nov;15(11):e1008100. doi: 10.1371/journal.ppat.1008100. eCollection 2019 Nov. PubMed PMID: 31710650; PubMed Central PMCID: PMC6874086.

Ziegler*, C. and Botten, J. Defective interfering particles of RNA viruses. Trends in Microbiology. 2020 Jul;28(7):554-565. doi: 10.1016/j.tim.2020.02.006. Epub 2020 Mar 26. Review. PubMed PMID: 32544442; PubMed Central PMCID: PMC7298151. * Note our submitted electron micrograph of virus particles budding was selected as the cover photo for this issue.

1. Secinaro, MA, Fortner, KA, Collins, C, Rincon, M, and Budd, RC. Glycolysis induced MCJ expression that links T cell proliferation with caspase-3 activity and death. Frontiers in Cell and Developmental Biology. 7(28): 1-10, 2019. PMID: 30915331.

2. Collins C, Lui Y, Santos AM, Ballif BA, Gogerly-Moragoda AM, Brouwer H, Ross R, Balagurunathan K, Sharma S, Wright GJ, Davis S, Budd RC. Detection of Cell Surface Ligands for Human Synovial γδ T Cells. J. Immunol. 203:2369-2376, 2019. PMID 31548331.

3. Fortner, KA, Blanco, LP, Buskiewicz, I, Huang, N, Gibson, PC, Cook, DL, Pederson, HL, Yuen, PST, Murphy, MP, Perl, A, Kaplan, MJ, and Budd, RC. Targeting Mitochondrial Oxidative Stress with MitoQ Reduces NET Formation and Kidney Disease in Lupus-Prone MRL-lpr Mice. Lupus Sci and Med. 2020;7:e000387. doi:10.1136/lupus-2020-000387.

4. Ziegler CM, Dang L, Eisenhauer P, Kelly JA, King BR, Klaus JP, Manuelyan I, Mattice EB, Shirley DJ, Weir ME, Bruce EA, Ballif BA, Botten J. NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z. PLoS Pathogens, 2019 Nov;15(11):e1008100. doi: 10.1371/journal.ppat.1008100. eCollection 2019 Nov. PubMed PMID: 31710650; PubMed Central PMCID: PMC6874086.

5. Graham, N., Eisenhauer, P., Diehl, S., Pierce, K.K., Whitehead, S.S., Drubin, A.P., Kirkpatrick, B.D., Sette, A., Weiskopf, D., Boyson, J., and Botten, J. Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans. Frontiers in Immunology, 2020;11:479. doi: 10.3389/fimmu.2020.00479. eCollection

117

2020. PubMed PMID: 32265929; PubMed Central PMCID: PMC7105617

6. Bruce, E., King, B., Botten, J. Single molecule FISH for detection and quantitation of arenavirus RNA species. RNA-FISH: Methods and Protocols, a book by Springer Nature. 2020 (In Press)

7. Bruce EA, Huang ML, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers JW, Jerome KR, Botten JW. Direct RT-qPCR Detection of SARS-CoV-2 RNA from Patient Nasopharyngeal Swabs Without an RNA Extraction Step. bioRxiv, 2020 Apr 6;. doi: 10.1101/2020.03.20.001008. PubMed PMID: 32511328; PubMed Central PMCID: PMC7239058.

8. Pettit SD, Jerome KR, Rouquié D, Mari B, Barbry P, Kanda Y, Matsumoto M, Hester S, Wehmas L, Botten JW, Bruce EA. 'All In': a pragmatic framework for COVID-19 testing and action on a global scale. EMBO Mol Med. 2020 Jun 8;12(6):e12634. doi: 10.15252/emmm.202012634. Epub 2020 May 27. PubMed PMID: 32375201; PubMed Central PMCID: PMC7267598.

9. *Ziegler, C. and Botten, J. Defective interfering particles of RNA viruses. Trends in Microbiology. 2020 Jul;28(7):554-565. doi: 10.1016/j.tim.2020.02.006. Epub 2020 Mar 26. Review. PubMed PMID: 32544442; PubMed Central PMCID: PMC7298151. * Note our submitted electron micrograph of virus particles budding was selected as the cover photo for this issue.

118

Division of Infectious Diseases - Annual Report July 2019–June 2020 W. Kemper Alston, MD, MPH, Director http://www.uvm.edu/medicine/medicine/infectiousdisease/

The Infectious Diseases (ID) Division is comprised of twelve attending physicians and 3 mid-level providers dedicated to the diagnosis, management, prevention and investigation of infectious diseases. The division had a great year, providing outstanding patient care for those in the hospital as well as in the clinic and throughout the State, teaching fellows, residents, students, colleagues, and the community, performing cutting edge research, and providing administrative support for a variety of hospital functions. Obviously 2020 ushered in the onslaught of the COVID-19 pandemic, in response to which the Division provided leadership for the Medical Center, the Network, and the State.

The ID division performs about 150 inpatient consultations a month. We also staff a busy outpatient clinic seeing new consultations, hospital follow-ups, and caring for travelers, those living with HIV, hepatitis C, tuberculosis and refugees, among others. This effort includes the care of over 500 patients with HIV in four federally funded Com- prehensive Care Clinics in Vermont. The Division has contracts with the Vermont Department of Health to collaborate on antibiotic stewardship, the diagnosis and treatment of tuberculosis, and biological and pandemic influenza preparedness. The Division has a contract with the VT Department of Corrections to consult on hepatitis C. The ID staff includes the UVM Medical Center Hospital Epidemiologists and Director of Infection Prevention, Director of Antibiotic Stewardship, Director of Clinical Ethics, the Larner College of Medicine Clerkship Director for the Depart- ment of Medicine, and the Director of the Vaccine Testing Center at UVM.

We are becoming a UVM Health Network Division, welcoming ID physicians from Champlain Valley Physicians Hos- pital (Keith Collins and Madiha Tahir), and Central Vermont Medical Center (Jessie Leyse).

In addition to daily teaching rounds with medical students, residents and fellows, the faculty are actively involved in teaching several curses in the Larner College of Medicine. The ID Division accepts one fellow per year into a two- year fellowship training program. The graduating fellows have a 100% board certification pass rate. Our fellows have presented abstracts at national ID meetings, published peer reviewed articles, and authored book chapters. We are very proud of Dr. Prateek Ghatage who graduated this year.

Within our Division we have several active research laboratories, which support a number of clinical and basic science projects including those performed by a PhD faculty member (Jose Teixeira, PhD), graduate and visiting students, laboratory technicians, and often the 2nd year ID Fellow.

The Huston laboratory has been continuously funded by the NIH as well as the Gates Foundation and is working on the discovery of therapeutic agents for Cryptosporidium.

Investigations of the Kirkpatrick laboratories and Vaccine Testing Center (VTC) continue in the Department of Mi- crobiology and Molecular Genetics (MMG), in tight collaboration with the division of Infectious Diseases. It focuses on improving global health through the assessment of candidate vaccines, microbial diseases, and the understanding of human protective immune responses following vaccination and infection. The team continues to work on development of the NIH’s live attenuated tetravalent dengue vaccine, performs extensive work on dengue human immunology and correlates of protection, Zika vaccine development and immunology, rotavirus immune correlates of protection and human experimental challenge models for Cryptosporidium.

In addition to clinical revenues, financial support is provided by grants from the National Institutes of Health (NIH), especially NIAID, the Health Services Research Administration (HRSA) as well as contracts with regional hospitals, the VT Department of Health, and UVM Medical Center directorships.

Faculty

119

W. Kemper Alston, MD, MPH Professor . Division Chief, Infectious Disease Division . Attending Physician for Infectious Disease . Hospital Epidemiologist and Medical Director of Infection Prevention . Chair, Infection Prevention Committee, UVM Medical Center . Tuberculosis Consultant, State of Vermont . Medical Director, UVMMC Employee Health . Infection Prevention Consultant, Northwestern Medical Center . HIV care provider, Brattleboro Memorial Hospital, Comprehensive Care Clinic . Member, Medical Staff Quality Assessment and Improvement Committee, UVMMC . Member, Infectious Diseases Practice Subcommittee, Pharmacy and Therapeutics Committee, UVMMC . Member, Visiting Nurse Association of Chittenden and Grand Isle Counties, Quality Assurance and Perfor- mance Improvement Committee

Jean Dejace, MD Assistant Professor . Associate Director, Infectious Disease Fellowship Training Program . Attending Physician for Infectious Disease . CVPH attending (7/1/19 – 12/31/19)

Andrew Hale, MD Assistant Professor . Attending Physician for Infectious Disease . Director, Infectious Elective Rotation . Course Director, How the Hospital Works, 4th yr medical student course . Course Director, Comparative Physiology, Mount Desert Island Biological Laboratories . Course Director, Cancer Respiratory and Renal Pathophysiology at the UVM Larner College of Medicine . Chair, Vermont Hepatitis C Taskforce

Christopher D. Huston, MD Professor of Medicine with Tenure . Research Interests: Intestinal protozoan infections including E. histolytica host-parasite infections, Cryptospor- idium drug development . Attending Physician for Infectious Disease . Institutional Biosafety Committee, UVM . Research Committee, UVM Larner College of Medicine . Reappointment, Promotions and Tenure Committee, Department. of Medicine, UVM College of Medicine . Faculty search committee, Division of Endocrinology, Department of Medicine, UVM College of Medicine

Beth D. Kirkpatrick, MD, FIDSA, FASTMH Professor of Medicine with Tenure Chair, Department of Microbiology and Molecular Genetics . Director, UVM Vaccine Testing Center . Research Interests: Vaccine development, vaccine immunology, enteric and flavivirus infections, human experimental infection models. . College of Medicine Advisory Committee. UVM Larner College of Medicine. . Physician-Scientist Working Group. UVM Larner College of Medicine

Tim Lahey, MD, MMSc Professor of Medicine . Director, Clinical Ethics . Attending Physician for Infectious Disease

120

. Ombudsperson for Graduate Medical Education . Co-Chair, Unsafe Patient Behavior Task Force . Member, Discriminatory Patient Preferences Workgroup . Faculty co-advisor, Social Justice Coalition, UVM Larner College of Medicine . Faculty associate-advisor, Albert Schweitzer Fellowship, UVM Larner College of Medicine

Cindy Noyes, MD Associate Professor of Medicine . Attending Physician for Infectious Disease . Associate hospital epidemiologist . Associate Director, Infection Prevention

Kristen K. Pierce, MD Professor of Medicine . Director, Infectious Disease Fellowship Training Program . Attending Physician for Infectious Disease . Lead Clinical Investigator, Vaccine Testing Center . Research Interests: Development of Live Attenuated Flavivirus Vaccines . Institutional Review Board

Louis B. Polish, MD Associate Professor of Medicine . Director, Department of Medicine Inpatient Medicine Clerkship Program . Attending Physician for Infectious Disease

Devika Singh, MD, MPH Assistant Professor of Medicine . Director, Part C HRSA Award, Part B HRSA Sub Award, and NEAETC Sub Award . Attending Physician for Infectious Disease . HIV care provider, Rutland Regional Medical Center, Comprehensive Care Clinic . Consultant in pharmacovigilance/safety, Microbicide Trials Network (HIV/AIDS clinical trials network by the National Institute of Allergy and Infectious Diseases)

Lindsay M. Smith, MD Assistant Professor of Medicine . Director, UVMMC Antimicrobial Stewardship Program . Attending Physician for Infectious Disease . Co-Chair, IDCP sub-committee, Pharmacy and Therapeutics Committee

Jose E. Teixeira, PhD Faculty Scientist . Interests: Intestinal protozoan infections including E. Histolytica host-parasite infections, Cryptosporidium drug development

Timothy Whitman, DO Associate Professor of Medicine . Attending Physician for Infectious Disease . HIV care provider, Northeastern Vermont Regional Hospital, Comprehensive Care Clinic . Quality Assurance and Improvement Committee representative

Fellows

121

Prateek Ghatage, MD Infectious Disease 2nd Year Fellow . Infectious Disease Fellowship Training Program July 1, 2018 – June 30, 2020

Sean Bullis, MD Infectious Disease 1st Year Fellow . Infectious Disease Fellowship Training Program July 1, 2019 – June 30, 2021

Nurse Practitioners and Physician Assistants:

Jessica Terrien, PsychNP Comprehensive Care clinic, HIV patients . HIV Patient Care, mental health

Laura Catoe, ARNP Nurse Practitioner, Comprehensive Care clinic . Travel health . Vermont Refugee Clinic . General ID

Mary Claire Walsh, NP Nurse Practitioner, Comprehensive Care Clinic / Vaccine Testing Center . General ID

Graduate Students, Post-doctoral Fellows, MD PhD Students:

Md Mahmudul Hasan – PhD Student (Huston Laboratory) Bethany Mihavics—PhD Student (Huston Laboratory) Ethan Mattice—PhD Student (Huston Laboratory)

Endowed Professorships:

Leadership in Professional Societies:

Christopher Huston, M.D.  Member, American Society for Microbiology Council on Microbial Sciences

Beth Kirkpatrick, MD, FIDSA, FASTMH  Global Health Committee, Infectious Disease Society of America  Institutional Representative, American Society for Clinical Investigation (ASCI)  Scientific Advisory Board. Symposium on Controlled Human Experimental Infection Models. International Alliance for Biologic Standardization (IABS)

Tim Lahey, MD, MMSc  Member, United States Medical Licensing Examination Microbiology and Immunology Test Material De- velopment Committee  Member, United States Medical Licensing Examination Step 1 Interdisciplinary Review Committee

122

 Member, United States Medical Licensing Examination General Principles/Foundational Science Task Force

External Reviewer, Editorships and Editorial Boards:

W. Kemper Alston, MD o External reviewer . Annals of Internal Medicine, . Clinical Infectious Diseases . Infection Control and Hospital Epidemiology

Andrew Hale, MD o External reviewer  Medical Teacher  Teaching and Learning in Medicine  BMJ Open  ID Cases: received “Reviewer Recognition” in 2019, 2020  Contributing writer, Contagion  Journal of Graduate Medical Education  Cancer Causes and Control  Therapeutic Advances in Infectious Disease  PLOS Medicine  Case Reports in Infectious Diseases  Journal of the American Podiatric Medical Association

Christopher Huston, MD o Editorial Board Member – Infection and Immunity o External reviewer  PLoS Pathogens  PLoS Neglected Tropical Diseases  PLoS ONE  mBio  Antimicrobial Agents and Chemotherapy  Journal of Infectious Diseases  Clinical Infectious Diseases  ACS Infectious Diseases  Cellular Microbiology  Molecular Microbiology  Molecular and Biochemical Parasitology  Journal of Clinical Microbiology  American Journal of Tropical Medicine and Hygiene

Beth Kirkpatrick, MD, FIDSA, FASTMH o Section Editor, American Journal of Tropical Medicine and Hygiene 2014-present o External Reviewer . American Journal Tropical Medicine and Hygiene . Clinical Infectious Diseases . Journal Infectious Diseases . Lancet Infectious Diseases . PLOS Neglected Tropical Diseases . PLOS Pathogens

123

. PLOS ONE . Vaccine

Tim Lahey, MD, MMSc o External Reviewer . Clinical Infectious Diseases . Academic Medicine . The Lancet Respiratory Medicine . AMA Journal of Ethics

Kristen Pierce, MD o External reviewer  American Society of Tropical Medicine and Hygiene

Study Sections and Federal Advisory Boards:

Christopher Huston, MD o Ad-Hoc Reviewer - National Institutes of Allergy and Infectious diseases o 2019, ZRG1 IDM-M(02) (Vector and Eukaryotic Pathogens Study Section) o 2019, ZRG1 IDM-S(02) M (Topics in Drug Discovery and Clinical Field Studies Study Section) o

Beth Kirkpatrick, MD, FIDSA, FASTMH o Indo-US Vaccine Action Program, Candidate Vaccine Advisory Committee (CVAC). - international Vaccine Working Group

Kristen Pierce, MD o ACIP American Council on Immunization Practices – CDC working group on Flavivirus Vaccines o Indo-US Vaccine Action Program, Candidate Vaccine Advisory Committee (CVAC). – international Vaccine Working Group

Major Faculty Awards:

Andrew Hale, MD UVMMC Foundations Awards Nominations  Dean Warsahaw Integration Award  Above and Beyond Award  Foundations Course Director Award UVM LCOM Professionalism Accolade Commencement Speaker; UVM Internal Medicine Residency Graduation

Tim Lahey, MD, MMSc Albert Schweitzer Fellowship Leadership Award 2019

Cindy Noyes, MD University of Vermont Medical Center Department of Medicine, Distinguished Clinician Award

Grants – list all active by faculty member, PI

Andrew Hale, MD

124

Frymoyer Scholars Program 7/1/18-6/30/20 Optimizing Care for Vermonters Infected with Hepatitis C Virus through a Statewide Educational Curriculum $50,000

Andrew Hale, MD (PI) HIV/HCV Care for Incarcerated Persons in Vermont Consultant for the State of Vermont Department of Corrections contractor for optimizing care of HIV and HCV infected persons who are incarcerated in Vermont. 3/1/2019-2/28/2020 $48,000 per year

Andrew Hale, MD (PI) Eureka Grant, University of Vermont Department of Medicine. The Impact of Infectious Diseases Provider Involvement on Asplenic Care Outcomes 4/11/2019-6/30/2022 $10,000

Chris Huston (Co-investigator (5%)) (Jason Botten is the PI) NASA Jet Propulsion Laboratory Title: Screening of novel anti-SARS-CoV-2 peptides for infection of Vero E6 cells with SARS-CoV-2 June 1, 2020-December 31, 2020 Direct costs: $100,000

Christopher Huston, MD (PI) Merck Serono Project title: Screening the Merck “mini-library” for anti-Cryptosporidium drug activity Role: Principal investigator (2.6% effort) 12/1/2015-12/31/2019 Direct costs: $ 43,547 Total costs: $ 67,032

Christopher Huston, MD (PI) National Institute of Allergy and Infectious Diseases R21 AI130807 Project title: Continuous in vitro culture and treatment of Cryptosporidium using small molecule differentiation inhibitors Role: Principal investigator (10% effort) 1/25/2017-12/31/2019 (NCE) Direct costs: $275,000 Total costs: $ 419,375

Christopher Huston, MD Griggs (PI) Subcontract from Grant #OPP1161880 from St. Louis University (Griggs, PI) Bill and Melinda Gates Foundation Project title: Pharmacokinetic and pharmacodynamics profiling of compounds with known anti-Cryptosporidial activity to promote their improvement and advancement for clinical development. Role: Principal investigator on UVM subcontract (5% effort) 07/01/2017-12/31/2019 UVM Direct costs: $116,699 UVM Total costs: $ 128,369

Christopher Huston, MD (PI) UVM Immunobiology COBRE Pilot Grant Program

125

Project Title: Manipulating the gut microbiota to prevent cryptosporidiosis. Role: Principal Investigator (0% effort) 07/01/2017-06/30/2019 Direct costs: $50,000 Total costs: $ 50,000

R01 AI143951 Christopher Huston, MD (PI) National Institutes of Allergy and Infectious Diseases (NIAID) Project title: Preclinical optimization of a parasiticidal drug for cryptosporidiosis The goal of this project is to develop a new drug candidate for treating cryptosporidiosis and determine its molecular mechanism of action, beginning with a piperazine-based lead compound identified through phenotypic screening. Role: Principle investigator (multi-PI grant; Huston lead (20% effort)) 3/01/2019-02/29/2024 UVM Direct costs: $1,088,495 UVM Total costs: $1,682,577

R21/R33 AI141184 Christopher Huston, MD (PI) National Institutes of Allergy and Infectious Diseases (NIAID) Project title: Repurposing the EMD-Serono “mini-library” for Cryptosporidium drug development. The goal of this project is to develop a new drug candidate for treating cryptosporidiosis, using high-value EMD- Serono compounds as the chemical starting points. Role: Principle investigator (multi-PI grant; Huston lead (10% effort)) 2/01/2019-12/31/2024 UVM Direct costs: $297,992 UVM Total costs: $456,623

Christopher Huston MD (Co-PI) (10% effort) Gilbert (PI) (University of Dundee) Medical Research Council (Great Britain) Project title: Development of new agents for the treatment of cryptosporidiosis Role: Principal investigator of sub-project at UVM (10% effort) 1/2019-8/2021 UVM Direct costs: $330,884 UVM Total costs: $330,884

P20GM125498 Kirkpatrick (PI) National Institutes of General Medical Sciences Center of Biological Research Excellence (COBRE) Project title: Translational Research to Prevent and Control Global Infectious Diseases (Translational Global Infec- tious Diseases Research Center, TGIR) The goal of this project is to establish a center for translational infectious diseases research at UVM by facilitating interactions between faculty in the biological sciences with faculty in the engineering and data sciences. Role: Co-principal Investigator (20% effort) 10/01/18-09/30/23 UVM Direct costs: $7,515,013 UVM Total costs: $11,515,478

NIH U01 AI141997 Kirkpatrick, Diehl, Botten (MPI) Mechanisms of Protection and Durability for a Live, Attenuated Tetravalent Dengue Vaccine This work seeks to clarify the immune components and mechanisms of durable protection of a live tetravalent dengue vaccine. 02/2019-01/2024

Bill & Melinda Gates Foundation (Kirkpatrick (PI)

New Paradigms of Campylobacter Persistence and Transmission in Zimbabwean Infants.

126

This work follows our observations of human Campylobacter recrudescence and uses meta- genomic sequencing in a new birth cohort to re-examine reservoirs and transmission of this important pathogen. This data may improve prevention of an important cause of infant diarrhea and poor health in low-income settings. 1/2019-12/2022

NIH P20 GM125498-01 Kirkpatrick (PI) 10/2018-9/2023 Center of Biomedical Research Excellence (COBRE) award for the Translational Global Infectious Disease Research (TGIR) Center. This award supports institution-wide growth in global Infectious Disease research and the support and development of junior faculty (from both biomedical and computational/quantitative data fields) toward research independence. 10/2018-9/2023

Beth D. Kirkpatrick, MD Principal Investigator Improving Rotavirus Vaccination: Refining Correlates of Protection and Immunologic Responses to Vaccination. The major goals of this project are to permit better understanding and use of immunologic markers (correlates) of protection and identify the optimal immunologic responses and variables inhibiting responsiveness to rotavirus vaccination. $2,200,000 (2015-2019) Bill and Melinda Gates Foundation

Beth D. Kirkpatrick, MD Site Principal Investigator Operation of a Facility for the Study of Infectious Agents, Vaccines, and Antimicrobials in Adult and Pediatric Hu- man Subjects. This award supports the design and implementation of a series of large outpatient clinical studies and basic immunology evaluations of novel live flavivirus (e.g. Dengue, West Nile, Zika) virus vaccines and human challenge models. $9,000,000 (2009-2019) National Institutes of Health and Johns Hopkins University

Devika Singh, MD, MPH (Principal Investigator) Eureka Grant, The Sexual and Reproductive Health Experiences of Women Infected with HIV in Vermont 2019-2020 Award: $10,000

Devika Singh, MD New England AIDS Education Training 7/1/2019 – 6/30/2020 $49,039 Federal sub-award, UMASS

Devika Singh, MD (PI) Ryan White Part C Grant for HIV Care 5/1/2019– 4/30/2020 $ 530,005 Federal HRSA

Devika Singh, MD (PI) Ryan White Part C Grant for HIV Care 5/1/2020 – 4/30/2021 $ 530,005 Federal HRSA

Devika Singh, MD (PI) Ryan White HIV/AIDS Program Part C EIS Covid-19 Response 4/1/2020 – 3/31/2021 $ 77,125 Federal HRSA

127

Devika Singh, MD (PI) Ryan White Care Act Part B Sub Award 1/1/2019– 12/31/2019 $290,000 Federal HRSA

Devika Singh, MD (PI) Ryan White Care Act Part B Sub Award 1/1/2020– 12/31/2020 $340,000 Federal HRSA

Lindsay M. Smith, MD Vermont Department of Health Antimicrobial Stewardship Grant 6/1/17 – 4/30/20 Total Direct Costs $410,939

Publications – peer reviewed, chapters, etc. (not abstracts)

Bullis S, Crothers J, Wayne S, Hale A. A Cautionary Tale of False-Negative Covid-19 Testing. IDCases, May 5, 2020. doi.org/10.1016/j.idcr.2020.e00791

Bullis S, Hale A. Where to Treat Uncomplicated HCV? Assessing the Impact of Shifting Care From Specialists to PCPs. Contagion October, 2019. Available at: https://www.contagionlive.com/publications/contagion/2019/october/where-to-treat-uncomplicated-hcv-assessing-the-impact-of-shifting-care-from-specialists-to-pcps

Bullis S, Krywanczyk A, Hale A. Aspergillosis Myocarditis in the Immunocompromised Host. IDCases. 2019(17):e00567. doi.org/10.1016/j.idcr.2019.e00567

Bullis S, Hale A. Improving Vaccine Uptake in a Cohort of Patients with Asplenia. Contagion June, 2020. In press.

Dimarco D, Hale A (co-first author), Ulano A, Smith L. Metastatic Malignancy Masquerading as Neurocysticer- cosis. IDCases. 2019(18):e00596. doi.org/10.1016/j.idcr.2019.e00596 Freed J, Hale A, Ricotta D, Huang G. From Monotony to Motivation: Effective Presentation of Epidemiological Data. Academic Medicine 2019 Sep 03. PMID: 31490193.

Hale A, Mathison B, Pritt B, Collins K. Endemic Bot Fly Larvae Infection in Northern New York State. IDCases. 2019(16):e00531. doi.org/10.1016/j.idcr.2019.e00531

Ricotta D, Ranchoff B, Beltran C, Hale A, Freed J, Huang G. The Mindful Manager: Validation of a Resident-As- Leader Direct Observation Instrument. Accepted at Journal of General Internal Medicine September 9, 2019. Freed J, Hale A, Ricotta D, Rangachari D. 12 Tips for Teaching Oncology to Non-Oncolo- gists. Accepted at Medical Teacher October 16, 2019. doi.org/10.1080/0142159X.2019.1682534

128

Ricotta D, Hale A, Freed J, Taylor J, Smith CC. Peer Observation to Develop Resident Teaching. The Clinical Teacher December 2, 2019 (in press).

Ricotta DN, Freed J, Hale A. Things We Do For No Reason: Card Flipping Rounds. Journal of Hospital Medicine December 17, 2019, in press.

Stephenson KE, Tan CS, Walsh SR, Hale A, Ansel JL, Ananos D, Jaegle K, Peter L, Nkolola J, Makoni T, Fogel R, Bradshaw C, Tyler A, Moseley E, Chandrashekar A, Yanosick KE, Seaman MS, Eckels KH, De La Barrera RA, Thompson J, Dawson P, Thomas SJ, Michael NL, Modjarrad K, Barouch DH. Safety and immunogenicity of a purified inactivated Zika virus vaccine candidate given via standard versus accelerated vaccination schedules: a phase 1, single-center, double-blind, sequential-group, randomized, placebo-controlled clinical trial. Lancet Infectious Diseases February 7, 2020, in press. doi.org/10.1016/S1473- 3099(20)30085-2

Hale A, Freed J, Ricotta DN. Weak Wellness. American Journal of Medicine February 14, 2020, in press.

Hale A, Ricotta D, Freed J, Smith CC, Huang G. Comparing Two Adapted Maslow’s Hierachy of Needs Frame- works on Physician Wellness. American Journal of Medicine March 10, 2020, in press.

Hale A, Ricotta DN, Freed J. Important Consults are Not Always Perfect. Academic Medicine June 15, 2020, in press.

Hale A, Glassman R, Brett M, Epstein M, Skinner N, Olston G, Freed R, Ricotta A, Fessler D, Nathavitharana R, Stead W. Core Curriculum in Infectious Diseases. American Associated of Medical Colleges (AAMC) iCollabora- tive. March 29, 2020. Available at: https://icollaborative.aamc.org/resource/5004/

Gilson PR, Nguyen W, Poole W, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD,White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE. Evaluation of 4-amino 2-anilino- quinazolines against Plasmodium and Apicomplexa parasites in vitro and in a P. falciparum hu- manized NOD-scid-IL2Rγnull mouse model of malaria. Antimicrobial Agents and Chemother- apy. 2019. Feb 26; 63(3). pii: AAC.01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar. PMID: 30559138

Buckner FS, Ranade RM, Gillespie JR, Shibata S, Hulverson MA, Zheng Z, Huang W, Choy R, Verlinde CLMJ, Hol WGJ, Choy RKM, Van Voorhis WC, Arnold SLM, Jumani RS, Hus- ton CD, Fan E. Optimization of methionyl tRNA-synthetase inhibitors for treatment of Cryp- tosporidium infection. Antimicrobial Agents and Chemotherapy. 2019. Mar 27;63(4). pii: e02061-18. doi: 10.1128/AAC.02061-18. Print 2019 Apr. [Selected as editor’s pick.] PMID: 30745384

Bargaña B, Forte B, Choi R, Hewitt SN, Bueren-Calabuig JA, Pisco JP, Peet C, Robinson DA,

129

Jansen C, Dranow DM, Norcross N, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Jimenez-Diaz JB, Jumani RS, Lorimer DD, Love M, Maher S, Matthews H, McNamara C, Miller P, O’Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottman M, Sanz LM, Scullion P, Shama A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Fran- cisco-Javier G, Maser P, Kyle D, Winzeler E, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Pisliakov AV, Fairlamb AH, Walpole C, Read KD, Van Voorhis WC, Gilbert IH. Lysyl-tRNA synthetase as a drug target in apicomplexan parasites. Proceedings of the National Academy of Sciences USA. 2019. 116:7015-7020. PMID: 30894487

Jumani RS, Hasan MM, Stebbins EE, Donnely L, Miller P, Klopfer C, Bessoff K, Teixeira JE, Love MS, McNamara CW, Huston CD. A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptospor- idium growth inhibitors. Nature Communications. 2019. Apr 23;10(1):1862. doi: 10.1038/s41467-019-09880-w. [selected as Editor’s pick] PMID: 31015448

Lee S, Ginese M, Girouard D, Beamer G, Huston CD, Griggs DW, Tzipori S. Piperazine-derivative MMV665917 as an effective drug against Cryptosporidium hominis evaluated in the piglet diarrhea model. Journal of Infectious Diseases. 2019. Mar 20. pii: jiz105. doi: 10.1093/infdis/jiz105. [Epub ahead of print]. PMID: 30893435

Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosen- thal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD. Identification of a potent benzox- aborole drug candidate for treating cryptosporidiosis. Nature Communications. 2019. Jun 27;10(1):2816. doi: 10.1038/s41467-019-10687-y. [selected as Editor’s pick] PMID: 31249291

Ehrenkaufer G, Li P, Stebbins EE, Kangussu-Marcolino MM, Debnath A, White CV, Moser MS, DeRisi J, Gisselberg J, Yeh E, Wang SC, Company AH, Monti L, Caffrey CR, Huston CD, Wang B, Singh U. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Neglected Tropical Diseases. 2020. Mar 20;14(3):e0008150. doi: 10.1371/journal.pntd.0008150. eCollection 2020 Mar. PMID: 32196500

Bruce EA, Tighe S, Hoffman JJ, Laaguiby P, Gerrard DL, Diehl SA, Leonard DGB, Huston CD, Kirkpatrick BD, Crothers JW, Dragon J, Botten J. RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swab using Qiagen RNeasy kits or directly via omission of an RNA extraction step. bioRxiv. March 21, 2020. https://www.biorxiv.org/content/10.1101/2020.03.20.001008v1

Hasan M, Teixeira JE, Lam YW, Huston CD. Coactosin phosphorylation controls Entamoeba histolytica cell membrane protrusions and cell motility. mBio. 2020. (In press (accepted))

Huston CD. Editorial commentary: The CRYPTOFAZ trial and lessons learned for anticryp- tosporidial drug development. Clinical Infectious Diseases. 2020. Apr 11. pii: ciaa425. doi: 10.1093/cid/ciaa425. [Epub ahead of print]. PMID: 32277815

130

Choy R, Huston CD. Editorial commentary. Cryptosporodiosis should be designated as a tropical disease by the US Food and Drug Administration. PLoS Neglected Tropical Diseases. 2020. Jul 2;14(7):e0008252. doi: 10.1371/journal.pntd.0008252. PMID: 32614819

Huston CD. Intestinal Protozoa. In: Feldman F, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Saunders Com- pany. 2020

Campbell RA, Schwertz H, Hottz ED, Rowley JW, Manne BK, Washington AV, Hunter-Mellado R, Tolley ND, Christen- sen M, Eustes AS, Montenont E, Bhatlekar S, Ventrone CH, Kirkpatrick BD, Pierce KK, Whitehead SS, Diehl SA, Bray PF, Zimmerman GA, Kosaka Y, Bozza PT, Bozza FA, Weyrich AS, Rondina MT. Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3. Blood. 2019 May 9;133(19):2013-2026. doi: 10.1182/blood-2018-09-873984. Epub 2019 Feb 5. PMID: 30723081

Donowitz JR, Parikh HI, Taniuchi M, Gilchrist CA, Haque R, Kirkpatrick BD, Alam M, Kakon SH, Islam BZ, Afreen S, Kabir M, Nayak U, Colgate ER, Carmolli MP, Petri WA Jr. Increased Fecal Lactobacillus Is Associated With a Positive Glucose Hydrogen Breath Test in Bangladeshi Children. Open Forum Infect Dis. 2019 Jun 1;6(7):ofz266. doi: 10.1093/ofid/ofz266. eCollection 2019 Jul. PMID: 31281862

Lahey T. Undercover in a hospital bed. The New York Times. July 16, 2019. https://www.ny- times.com/2019/07/16/well/live/secret-shopper-hospital.html

Lahey T. When the best medicine means asking parents to leave the room. The Washington Post. September 17, 2019. https://www.washingtonpost.com/lifestyle/2019/09/17/when-best-medicine-means-asking-parents-leave-exam-room/

Lahey T. An unproven vaccine is too risky. The New York Times April 16, 2020 https://www.ny- times.com/2020/04/16/opinion/coronavirus-vaccine-research.html

Pinto-Powell R and Lahey T. Just a game: the dangers of quantifying medical student professionalism. Journal of General Internal Medicine 2019 Aug;34(8):1641-1644. doi: 10.1007/s11606-019-05063-x. https://rdcu.be/bFd1p.

Lahey T & & Nelson W. A Dashboard to Improve the Alignment of Health Care Organization Decisionmaking to Core Values and Mission Statement. Cambridge Quarterly of Healthcare Ethics 2020 Jan;29(1):156-162. d PMID: 31858947 DOI: 10.1017/S0963180119000884

Lahey T. Drug testing is no substitute for honesty and addiction risk reduction. American Journal of Bioethics 2020; 20:1, 75-77.

Lahey T & Elwyn G. Is shared decision making impossible when patients have reduced decision-making capacity? AMA Journal of Ethics 2020 (in press).

Moulton H, Moulton B, Lahey T, Elwyn G. Can Consent to Participate in Clinical Research Involve Shared Deci- sion Making? AMA J Ethics. 2020 May 1;22(5):E365-371. doi: 10.1001/amajethics.2020.365.PMID: 32449651

Lahey T, Elwyn G. Sliding-Scale Shared Decision Making for Patients With Reduced Capacity. AMA J Ethics. 2020 May 1;22(5):E358-364. doi: 10.1001/amajethics.2020.358.PMID: 32449650

131

Polish LB, Pritt B, Barth TFE, Gottstein B, O'Connell EM, Gibson PC. Echinococcus multilocularis: First European haplotype identified in the United States: An emerging disease? Clin Infect Dis. 2020 Mar 21:ciaa245. doi: 10.1093/cid/ciaa245. Online ahead of print. PMID: 32198510

Peebles K, Kiweewa FM, Palanee-Phillips T, Chappell C, Singh D, Bunge KE, Naidoo L, Makanani B, Jeenarain N, Reynolds D, Hillier SL, Brown ER, Baeten JM, Balkus JE; , MTN-020/ASPIRE study team. Elevated Risk of Bacte- rial Vaginosis among Users of the Copper Intrauterine Device: A Prospective Longitudinal Cohort Study. Clin Infect Dis. 2020 Jun 6:ciaa703. doi: 10.1093/cid/ciaa703. Online ahead of print. PMID: 32505132

Mhlanga FG, Balkus JE, Singh D, Chappell C, Kamira B, Harkoo I, Szydio D, Mukaka S, Piper J, Hillier SL. Feasibil- ity and Safety of IUD insertion by Mid-Level Providers in Sub-Saharan Africa. Int Perspect Sex Reprod Health. 2019 Dec 17; 45:61-69. doi: 10.1363/45e8019 PMID: 31859669

Montgomery ET, Roberts ST, Nel A, Malherbe M, Torjesen K, Bunge K, Singh D, Baeten JM, Marrazzo J, Chirenje ZM, Kabwigu S, Beigi R, Riddler SA, Gaffour Z, Reddy K, Mansoor LE, Nair G, Woeber K, Moodley J, Jeenarian N, Siva S, Naidoo L, Govender V, Palanee-Phillips T. Social harms in female-initiated HIV prevention method research: state of the evidence. AIDS. 2019 Nov 15; 33 (14): 2237-2244. doi: 10.1097/QAD.0000000000002346. PMID: 31408030

Chappell CA, Harkoo I, Szydlo DW, Bunge KE, Singh D, Nakabiito C, Mhlanga F, Kamira B, Piper JM, Balkus JE, Hillier SL. Contraceptive method switching among women living in sub-Saharan Africa participating in an HIV-1 prevention trial: a prospective cohort study. Contraception. 2019 Sep; 100(3): 214-218. doi: 10.1016/j.contraception.2019106.006. Epub 2019 Jun19. PMID: 31226323

Feasibility and Safety of IUD Insertion by Mid-Level Providers in Sub-Saharan Africa. Mhlanga FG, Balkus JE, Singh D, Chappell C, Kamira B, Harkoo I, Szydlo D, Mukaka S, Piper J, Hillier SL. Int. Perspect Sex Reprod Health. 2019 Dec 17;45:61-69

132

DIVISION OF NEPHROLOGY

Annual Report – July 1, 2019-June 30, 2020

A. Executive Summary:

2020 has been a challenging year for the Division. We saw a reduction in available FTE, through retirement (Dr. Rimmer), reduction in clinical FTE% (Drs. Hood, Solomon, and Weise), and transitions to other positions within the Department of Medicine (Megan Houston, ANP). These changes stressed our remaining staff with coverage of our six dialysis units, in-patient service at UVMMC, and outpatient services at Burlington, Newport, Rutland, and Barre that represent the only nephrology referral sites in Vermont. The COVID-19 pandemic was actually an important opportunity to address some of the stresses caused by staffing shortages. We had already started virtual visits using Zoom in some of our dialysis unit to minimize travel time/expenses. The pandemic made it clear that all of our dialysis units needed to be Zoom capable and our outpatient clinics needed to quickly become capable as well. The transition was relatively smooth with clinic encounters at pre-COVID levels by June, with 90% being conducted by phone or Zoom. Because dialysis is not an ‘elective’ procedure, our dialysis visits/RVU’s were maintained through the shut-down.

What was put on hold were research efforts involving patients – on-going recruitment into trials was halted while existing patients were followed remotely. We are now back to active enrollment including our two investigator- initiated trials. Dr. Kat Cheung was successful with a number of competitive grants including the COBRA grant on neural and brain microcirculatory health.

We did manage to attract one new faculty member – Dr. Enyinna – who will join us in October 2020 replacing Dr. Susarla who will be returning to India by the end of the year. We continued another year without fellows, reflect- ing the national shortage of residents interested in a career in Nephrology. Our fellowship slots were reduced from 2 per year to 1 per year. We remain optimistic that this next recruiting year may bring renewed interest in Ver- mont as a place to live during fellowship. Dr. Alison Fitzgerald will be taking the reins from Dr. Weise and leading the program.

Despite the many challenges associated with the loss of clinical FTE (higher workload, more nights and weekends on call), EMR upgrades, financial constraints on variable compensation, loss of childcare services affecting some of our junior faculty, the Division scored extremely well on provider satisfaction and was one of the lowest on the burnout survey. None of the above changes have diminished patient access and the quality of care delivered. In- deed, the Division was a leader in the Press-Gainey patient satisfaction survey.

As we move into FY21, the Division is starting an ACO funded ‘navigator’ program to work specifically with patients who are nearing end stage renal disease. The recently hired navigator will be interacting with these patients, educating them with regard to diet, dialysis, transplantation, and palliative care options, establishing ‘goals of care’ documents, and facilitating the transition to a path consistent with those patient goals. The ultimate goal is to improve the patient experience and reduce hospitalizations and costs associated with developing end stage kidney disease.

Education The Division has a number of faculty who are members of the Teaching Academy including at least one Master Teacher. The clinical experience of medical students and residents on the Nephrology service has continued to change such that more than 50% of time is now in the outpatient arena. The pandemic has added some additional challenges but currently residents and students are paired with a nephrology attending and participate in their clinics. Patients are discussed as the encounters take place and at the end of the clinic, there is a summary meeting to review all the patients seen.

We had a very successful international observer program (2 per month) until the pandemic hit. We are hopeful that this program will be able to reopen in the future. Approximately 50% of the observers in our program have

133

been accepted into US medical residencies and we are hopeful that in the years to come, we may see some back as Nephrology fellows.

The Division has been in discussions with the nephrology community in Plattsburgh. Currently there are 4 nephrologists with one on a slow path to retirement and two junior people eager to pick up the patient load. Discussions on exactly how to integrate these two young nephrologists into the network were sidelined by the pandemic. I hope that we will be able to restart those discussions in the near future.

Patient Care RVU target FY19 – 32,210 Actual 30,066 (-6.7%) RVU target FY20 – 36,652 Actual 18,586 (-23.5%) as of May 2020

Arrived Visits target FY19 -6440 Actual 4305 (-33%) Arrived Visits target FY20 -6674 Actual 3196 (-27.8%) as of May 2020

B. Faculty Varun Agrawal, MD Associate Professor Medical Director of Barre Dialysis Unit Education of medical residents, burnout in nephrology fellows

Katherine Cheung, MD Assistant Professor of Medicine Frailty in chronic kidney disease, cognitive decline in end stage kidney disease

Alison Fitzgerald, MD Assistant Professor of Medicine Medical Director Newport Dialysis Unit Well-being of medical students

Virginia Hood, MD Professor of Medicine Director of Stone Clinic High value care, nephrolithiasis

Abhishek Kumar, MD Assistant Professor of Medicine Transplant, including cardiac transplant

Nina Narasimhadevara, MD Assistant Professor of Medicine Urinary oxygen as marker of kidney function

Macaulay Onuigbo, MD Professor of Medicine Director of Home Dialysis Unit Acute kidney injury

Marios Prikis, MD Associate Professor of Medicine Medical Director of Transplantation Transplantation

134

Jeff Rimmer, MD Professor of Medicine Medical Director Chittenden Dialysis Unit Hemodialysis,

Richard Solomon, MD Professor of Medicine Director, Division of Nephrology Medical Director of Acute Dialysis Unit Acute kidney injury

Sree Susarla, MD Assistant Professor of Medicine Medical Director of Rutland Dialysis Unit Nephrolithiasis

Wolfgang Weise, MD Associate Professor of Medicine Medical Director, St. Albans Dialysis Unit Glomerulonephritis

Alan Segal, MD Associate Professor of Medicine Per Diem Renal physiology

C. Fellows:

None

D. PA/NP:

Margaret Butler, APRN (outpatient hemodialysis and chronic kidney disease) She is our designated ‘superuser’ for EPIC Megan Houston, APRN (in patient hemodialysis)

E. Post-doctoral Fellows (Ph.D.) None

F. Endowed Professorship

Patrick Professorship (Dr. Solomon)

G1. Leadership in Professional Societies

o Kidney Disease Outcome Quality Initiative Education committee, National Kidney Foundation (Agrawal) o American Academy of Hospice and Palliative Medicine special interest group (Cheung) o American Geriatrics Society Junior Faculty Committee (Cheung) o Member, Kidney Supportive Care Work Group (Cheung) o Member, UVM Medical Center Board of Trustees, 2014-present (Hood) Chair, UVM Health Network Population and Quality Committee, 2017-present (Hood) Member, UVM Health Network Board of Trustees, 2017 –present (Hood)

135

o Member Executive Committee, International Society Internal Medicine 2015-present (Hood) o Member, Sydney University Graduate Union North America Board of Trustees (Hood) o Member, ACP Membership Committee (Hood) o Member, ACP Vermont Chapter Council (Hood) o President Emeritus, American College of Physicians (Hood) o Member of the European Board of Transplant Medicine, National representative (Prikis) Board Member and Examiner for the Transplant Medicine certification of the European Union of Medical Specialties (UEMS). (Prikis) o European network for Collaboration on Kidney Exchange Program – COST action (Prikis) o Chairman, Constitution and Bylaws Committee, Association of Nierian Physicians in the Ameri- cas (Onuigbo) o ESRD Network 1 Board of Directors (Rimmer) ESRD Network 1 Medical Review Committee (Rimmer)

G2: Larner College of Medicine, Department of Medicine

o Teaching Academy-Portfolio Review Committee, LCOM (Agrawal) o UVM Center for Aging, Executive Council (Cheung) o Department of Medicine Faculty Engagement and Communication Committee (Cheung) o Department of Medicine, Resident Research Committee (Cheung) o Chair, Practitioner Health Advocacy Committee (PHAC), LCOM (Fitzgerald) o Member, Medical Student Wellness Committee, LCOM (Fitzgerald) o Member, Professionalism, Communication and Reflection Committee, LCOM (Fitzgerald) o Member, Diversity of Inclusion, Department of Medicine, LCOM (Onuigbo) o Member, Larner College of Medicine Gender Equity Steering Committee (Onuigbo) o Member, The Robert Larner, M.D. College of Medicine Teaching Academy Educational Scholar Mentoring Group (Onuigbo) o Department of Medicine, Quality Assurance and Improvement Committee (Onuigbo) o University of Vermont Medical Center, Pharmacy and Therapeutics Committee (Onuigbo) o University of Vermont Medical Center, Medical Records Committee (Onuigbo) o Department of Medicine, Faculty Development Committee (Prikis) o Department of Medicine, Quality Improvement Committee (Rimmer) o Department of Medicine, Operations Committee, (Kumar) o Epic Dialysis Module “Power Team” (Rimmer) o Department of Medicine, Research Committee (Solomon)

H. Editorships and Editorial Boards

o Associate Editor, Journal of Medical Case Reports. Nov 2014 to present (V.Agrawal) o Associate Editor, BioMed Central Nephrology. Nov 2016 to present (V. Agrawal) o Member, Editorial Board, International Journal of Clinical Practice (Onuigbo) o Member, Editorial Board, BioMed Research International (Onuigbo) o Member, Editorial Board, Journal of Renal Injury Prevention (Onuigbo)

I. Study Section and Federal Advisory Boards

136

J. Major Faculty Awards o Election to Master Teacher, The Robert Larner, M.D. College of Medicine Teaching Academy, University of Vermont, Burlington, VT (Onuigbo) K. Grants (all grant accounts show a positive balance) – active 2016-2017

Federal o National Palliative Care Research Center Career development award ($154,000 over 2 years) – (Cheung) July 2018- Dec 2020) Telemedicine facilitated palliative care consultations in rural dialysis units– (Cheung)

o NIH-NIA R56 (June 2019-May 2021 - $23,500)-A Randomized-Clinical Trial of a Communication Tool to Improve Access to Palliative Care for Patients with End-Stage Renal Disease (Cheung- site PI)

o NIH-NIA R01 (June 2020-Feb 2025- $202,800) A Randomized-Clinical Trial of a Communication Tool to Improve Access to Palliative Care for Patients with End-Stage Renal Disease (Cheung- site PI)

o NIH RO1 DK113201 IMPROVE AKI: A Cluster-Randomized Trial of Team-Based Coaching Interventions to IMPROVE Acute Kidney Injury (Jeremiah Brown, PI) Role: Sub PI July 2018-June 2023 (Solomon)

University of Vermont

o UVM Medical Student Summer Research Fellowship. Association of urine findings with metabolic syndrome traits in a population of patients with recurrent nephrolithiasis (Hood) o Feasibility and acceptability of yogic breathing and meditation e-intervention in dialysis patients (2020 - $3000). (Cheung- mentor to medical student Jordan Carver) o One Care VT Pilot Project of Care Coordinator for Chronic Kidney Disease (Rimmer) - $300K for 2020 o Nicotinamide for treatment of hyperphosphatemia in patients with end stage kidney disease (Onuigbo) IRB 18-0487 o Aortic pathology and acute kidney injury in patients undergoing TAVR (Solomon/Dauerman) IRB 17- 0238 o Urine oxygen in patients undergoing cardiac surgery (Solomon/Leavitt) IRB 14-570

Multicenter Pharmaceutical supported grants

o Bayer Figaro and Fidelio Trials: Use of finerenone for patient with diabetes and chronic kidney disease (Solomon) IRB: 16-057 and 16-058 o REATA: Study of bardoxylone treatment in patients with autosomal dominant polycystic kidney disease (Solomon) IRB: Study 341 o AKEBIA: Study of valdulastat for treatment of anemia of chronic kidney disease (Rimmer) IRB 16- 706 o CALLIDITAS: Budesonide therapy in patients with IgA nephropathy (Solomon) IRB Study 15 o TRC101: Treatment of metabolic acidosis in patients with chronic kidney disease using a novel H+ binder (Solomon) IRB 19-0188 o APOLLO study: participating center (Prikis) o Cell free donor DNA (Allosure) in diagnosing BK nephropathy. Study run by Univ of Rhode island and CareDx- Pending budget approval, participating center (Prikis)

Funded but not yet started:

o UVMMG (MG191 - $50,000 ): A pilot crossover study of the impact of increased urine flow rate by oral hydration versus bolus intravenous furosemide infusion on urinary oxygen tension. (Narasimhade- vara, Onuigbo, Solomon)

137

o NIH-NIGMS o Cushman/Nelson (PI) o 8/2020-7/2023 Trajectories and vascular mechanisms of cognitive impairment in chronic kidney disease The goal of this study is to examine the trajectories of cognitive impairment in chronic kidney disease in the REGARDS study, to identify risk factors for rapid decline and to examine potential vascular mechanisms of cognitive impairment in CKD. Role: o Cheung, Project Director o Direct Costs: o $495,000 o

L. Publications

1. Cheung KL, LaMantia MA. Cognitive Impairment and Mortality in Patients Receiving Hemodialysis: Impli- cations and Future Research Avenues. Am J Kidney Dis. 2019 Jul 24;. doi: 10.1053/j.ajkd.2019.06.002. [Epub ahead of print] PubMed PMID: 31351689.

2. Bgvf98765in a Kidney Transplant Recipient: A Friend or Foe?. Case Reports in Transplantation, May 19th, 2020. https://doi.org/10.1155/2020/8108730

3. Intermittent pneumatic compression in patients with ESRD. Onuigbo MAC. Hemodial Int. 2019 Aug 19. doi: 10.1111/hdi.12777. [Epub ahead of print].

4. Spleno-renal anastomotic bypass revascularization for worsening renal failure and uncontrolled hypertension in bilateral calcific atherosclerotic renal artery stenosis. Onuigbo MAC, Engesser M, Susarla S. J Renal Inj Prev. 2019;8(4):253-256. DOI: 10.15171/jrip.2019.48.

5. Post-Renal Biopsy Acute Kidney Injury and Page Kidney from Intra-Renal Hematoma Aggravated by Re- versible Contrast-Induced Nephropathy Following Renal Arterial Embolization. Onuigbo MAC, Sharma V, Balogun OO, Ghimire A. Am J Case Rep, 2020; 21: e919701.

6. Pseudo-arterial temporary hemodialysis catheter placement in the left internal jugular vein ipsilateral to a preexisting brachio-axillary arteriovenous graft. Onuigbo MA, Agbasi N, Sarki B, Khan S, Wahlberg K. In- dian J Nephrol. 2020 Jan-Feb;30(1):29-31. doi: 10.4103/ijn.IJN_389_18. Epub 2019 Dec 27.

7. Position Statement on the Clinical Management of Hyperkalemia: A Narrative Review. Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, Hain DJ, Lerma E, Onuigbo M, Rastogi A, Roger SD, Spi- nowitz BS, Weir MR. Mayo Clinic Proceedings, 2020: In Press (An Expert Panel Report supported by Astra- Zeneca Pharmaceuticals LP).

8. Page kidney complicating kidney biopsy after stopping Apixaban: A physician's dilemma. Onuigbo MA, Sharma V, Balogun O, Ghimire A. Indian J Nephrol 2020;30:201-203.

9. Persistence of coronavirus disease 2019 (COVID-19) in patients with end-stage renal disease; An unrecog- nized phenomenon? Onuigbo MAC. J Renal Inj Prev. 2020; 9(x): x-x. doi: 10.34172/jrip.2020.xx.

10. Frailty among elderly patients on chronic maintenance hemodialysis for ESRD: Not simply a matter of chronological age. Onuigbo MAC, Agbasi N. Book Chapter. In: C.G. Musso, J.R. Jauregui, A. Covic, J.F. Macias-Nunez (eds.). Clinical Nephrogeriatrics. Springer. 2019. P 163-169.

11. Azarbal,A, Malenka,DJ, Huang,Y, Ross,CS, Solomon,RJ, DeVries,JT, Flynn,JM, But- zel,D, McKay,M, Dauerman,H. Recovery of kidney dysfunction after transcatheter aortic

138

valve implantation (from the Northern New England Cardiovascular Disease Study Group), Am J Cardio, 2019, 123 (3): 426-433, PMID 30522749.

12. Dae,MW, Liu,KD, Solomon,RJ, Gao,DW, Stillson,CA. Effect of low frequency therapeutic ultrasound (LOTUS) on induction of nitric oxide in chronic kidney disease – Potential to prevent acute kidney injury. (accepted) Kidney Diseases, 2020,

139

INVITED SPEAKER National and International: o National Kidney Foundation annual meeting (Solomon) March 2020 o Annual International Nephrology Congress (Solomon) June 2020 o American Academy of Hospice and Palliative Medicine, San Diego, CA March 2020 (Cheung) “ Breaking Access and Distance Barriers: Using Innovative Modalities of Tele-Palliative Care” (Cheung) Kathleen Foley Retreat, National Palliative Care Research Center, Jackson, WY, October 2019 “Kid- ney palliative care frontiers.” (Cheung) o Kidney Stones. 32nd Congresso SIMBA/ISIM symposium, Buenos Aires, Argentina, November 20, 2019 (Hood)Preventing Kidney Stone Recurrence. Royal North Shore Hospital, Sydney, Australia, March 4, 2020 (Hood)

Annals of Internal Medicine Audio files for On Being a Doctor, On Being a Patient, Ad Libitum:. (Hood) 2019: July 16; August 20; September 3; October 1; Nov 5, 19; December 17. 2020: January 21; April 7, 21; June 2;

140

Division of Pulmonary and Critical Care Medicine Anne Dixon MA, BM BCh, Director http://www.med.uvm.edu/medicine/pulmonary

The Pulmonary Critical Care Division has faced tremendous challenges related to the COVID epidemic during 2020; members of the Division emerged as local and national leaders spearheading our clinical response to the pandemic, and also undertaking major new research initiatives related to COVID. We welcomed three new faculty to the Divi- sion: Drs. Ram Baalachandran, Suman Majumdar and Zachary Weintraub. Meanwhile members of the faculty won major local and national awards. This has been a very successful year for the Division.

In the face of the COVID epidemic, members of the Division led planning efforts to care for critically ill patients in our region. Gil Allen served as lead of the Clinical Branch for the UVM Medical Center, Drs. Ryan Clouser and MaryEllen Antkowiak coordinated ICU planning for the pandemic, and Drs. Marta Kokosyznska and Morgan Clark Collier served on key committees planning our local surge responses for critically ill patients. On a national level, Renee Stapleton and Anne Dixon served on an ad-hoc COVID Committee put together by the ATS to provide input to PHARMA for clinical trials related to COVID. Dr. Josh Farkas provided data and clinical informational resources to the clinical community through his blog PulmCrit, which has been an important resource for disseminating up to date information to clinicians across the globe. A major new research development this year was undertaken by Jason Bates in response to the COVID epidemic: he spearheaded the development of a novel, low-cost ventilator, the “Vermontilator”. While we have been lucky enough not to need this here, this could be an important development for resource poor countries. The Vermontilator garnered major national attention, including from the New Yorker magazine. There have been a number of other significant new research initiatives and submitted grants related to COVID that we hope will lead to significant advances in our understanding and treatment of this devastating disease.

Members of the Division continued to be very productive, publishing approximately 100 peer-reviewed articles, editorials and book chapters during the last year, and obtained significant funding from a number of foundations and major grants from the NIH. Locally, Renee Stapleton and Matt Kinsey were recognized as Senior and Junior Researchers of the Year respectively, by the UVM Medical Group.

Members of the Division continue to have major national leadership roles: Dr. Stapleton is Chair of the Critical Care Assembly of the American Thoracic Society, and Dr. Dixon serves on the American Lung Association National Board of Directors, the “Expert Panel Review-4” guideline panel currently updating the NIH’s national asthma guidelines and the American Board of Internal Medicine Pulmonary Exam Board Committee. Members of the Division serve on numerous national grant review committees, and editorial boards for major publications. Dr. Jason Bates received national recognition for his contributions to science this year with the Solbert Permutt Award from the Res- piratory Structure and Function Assembly of the American Thoracic Society for contributions to Pulmonary Physiol- ogy and Medicine. Dr. Dixon was awarded the American Thoracic Society Distinguished Achievement Award for outstanding contributions to fighting respiratory diseases through research, education, patient care or advocacy, and Charles Irvin was awarded the inaugural Fred Taylor Award from NIH for outstanding contributions to the IDEA program.

The Division is committed to education and training, and trains 2 clinical fellows per year in pulmonary and critical care medicine, as well as a number of pre and post-doctoral research students. Dr. Garrison, our outstanding fellowship director, was recognized this year by the graduating medical school class with the “Clinical Teacher of the Year Award”, and by the Teaching Academy with an award for “Outstanding Contributions”. The last year has been a busy and successful year for the Division as outlined in detail for all members of the Divi- sion below.

141

Faculty Gilman Allen III, MD Professor of Medicine Director of Critical Care Services

MaryEllen Antkowiak, MD Assistant Professor of Medicine Co-Director Critical Care Services

Jessica Badlam, MD Assistant Professor of Medicine

Ramasubramanian Baalachandran, MBBS Assistant Professor of Medicine

Jason H.T. Bates, PhD DSc Professor of Medicine Department of Molecular Physiology & Biophysics

Jan Kirk Carney, MD MPH Professor of Medicine Associate Dean for Public Health

Ryan Clouser, DO Associate Professor of Medicine Network Medical Officer for Network Regional Transport System

Anne E. Dixon, MA, BM BCh Professor Medicine Director, Pulmonary Disease and Critical Care Medicine Director of Clinical Research, Vermont Lung Center

Joshua Farkas, MD Associate Professor of Medicine

Garth Garrison, MD Associate Professor of Medicine Program Director, Pulmonary and Critical Care Fellowship Co-Director, Lung Cancer Screening Program

Kathryn N. Huggett, PhD Director, Teaching Academy at the UVM College of Medicine Robert Larner, MD ’42 Professor in Medical Education Assistant Dean for Medical Education Curriculum design and evaluation Faculty development Medical education research

Charles Irvin, PhD Professor Department of Molecular Physiology & Biophysics Associate Dean for Faculty Affairs

David Kaminsky, MD

142

Professor of Medicine Medical Director, Pulmonary Function Lab Pulmonary physiology, pulmonary function testing, asthma, COPD

C. Matthew Kinsey, MD, MPH Assistant Professor of Medicine Director of Interventional Pulmonary -Quantitative imaging and computational modeling for identification of lung cancer -Application of endobronchial ultrasound transbronchial needle aspiration for development of novel precision medicine therapies for lung cancer -Interventional trials for COPD

Skyler Lentz, MD Assistant Professor of Medicine Emergency Medicine Physician

Suman Majumdar, MD Assistant Professor of Medicine

Prema Menon, MD, PhD Assistant Professor of Medicine

Katherine Menson, MD Assistant Professor of Medicine

Katelin Morrissette, MD Assistant Professor of Medicine

Polly E. Parsons, MD E.L. Amidon Professor of Medicine Chair, Department of Medicine

Matthew E. Poynter, PhD Professor Director of the Cellular, Molecular, and Biomedical Sciences Graduate Program Associate Director of the Vermont Lung Center Associate Director of the Multidisciplinary Training in Lung Biology T32 Training Grant Immunobiology of asthma Pathophysiology of obese asthma Alcohol-induced immunosuppression

Renee Stapleton, MD, PhD Professor of Medicine

Charlotte Teneback, MD Associate Professor Medical Director, Pulmonary Rehabilitation Director, Adult Cystic Fibrosis Center Director, Cystic Fibrosis Therapeutic Development Center Cystic fibrosis clinical care and research Pulmonary rehabilitation clinical practice and research

143

Zachary Weintraub, MD Assistant Professor of Medicine

Daniel Weiss, MD, PhD Professor of Medicine

Fellows Morgan ClarkColler, MD Brittany Duchene, DO Emily Ducomb, MD Brett Erdreich, MD Glenda Euceda, MD Elena Kozakewich, MD

Nurse Practitioners and Physician Assistants: Abe Sender, PA Sarah Wagner, NP Suzanne DeCapua, PA

Graduate Students, Post-doctoral Fellows, MD PhD Students: Anne E. Dixon, MD Ravishankar Chandrasakaren, PhD, Post-doctoral fellow Brittany Duchene, MD, Pulmonary fellow Swati Bhatawadekar, PhD, Post-doctoral fellow

Charles Irvin, PhD Sergio Maldonado Second Year Medical Student Ponce Health Science University, Ponce PR

C. Matthew Kinsey, MD, MPH Vitor Mori, Post-Doc Axel Masquelin, PhD student Emily DuComb, Pulmonary Fellow Heng Tan, medical student

Skyler Lentz, MD Specialty Mentor/Advisor for 2 MS4 LCOM students 2018-2019 Zach Ehret Robert Larner, MD College of Medicine, University of Vermont 2018-2019 Andrew Wick Robert Larner, MD College of Medicine, University of Vermont

Matthew E. Poynter, PhD Katherine Menson, DO (PCCM fellow) JJ Bivona (PhD candidate in Cellular, Molecular, and Biomedical Sciences (CMB) PhD Program)

Renee Stapleton, MD PhD Prema Menon, MD, Assistant Professor (research/faculty mentor) Katharine Cheung, Assistant Professor (research/faculty mentor)

Daniel Weiss, MD PhD Sara Enes PhD – Post-Doctoral Fellow Robert Pouliot PhD - Post-Doctoral Fellows

144

Juan Uriarte PhD - Post-Doctoral Fellows Evan Hoffman – Graduate Student Pauline DiGiannivittorio-Graduate Student Jayita Barua – Graduate Student

Endowed Professorships:

Leadership in Professional Societies: Gilman Allen, MD Cycled off the SCCM Congress Planning Committee in February 2020 after a three year term.

MaryEllen Antkowiak, MD Member of ATS membership committee

Anne E. Dixon, MA, BM, BCh Chair ATS Nominating Committee Chair American Lung Association Scientific Advisory Committee Member, American Lung Association National Board Member, American Lung Association National Board Executive Committee

David Kaminsky, MD Led effort to develop an American Thoracic Society statement on operating Pulmonary Function Labs during the COVID-19 pandemic: Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens: From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force.

C. Matthew Kinsey, MD, MPH Board of Directors, American Association of Bronchology and Interventional Pulmonology Member, Drug, Device, Development, and Discovery Committee, American Thoracic Society

2015-present American Thoracic Society: Drug, Device, Dis- Appointed Member covery, and Development (DDDD) Committee 2016-present American Lung Association: New England Lung Appointed Member Cancer Screening Task Force 2017-present Alliance for Oncology Clinical Trials: Respiratory Appointed Member and Prevention Committee 2017-present American Association for Bronchology and In- Elected Member terventional Pulmonology: Board of Directors 2018-present Advisory Board, Respiratory Innovation Appointed Member Summit

Skyler Lentz, MD American Academy of Emergency Medicine, Section of Critical Care Medicine At-Large Director (2019) Chair-Elect (2020)

Renee Stapleton, MD PhD American Thoracic Society Board of Directors, 2019-2021 Critical Care Assembly Chair, 2019-2021

145

Unrepresented Patients Working Group, member 2016-present Canadian Critical Care Nutrition Clinical Practice Guidelines Committee, External Panel Member, 2008-present ASPEN Physician Engagement Committee, member, 2018-19 Chair of Data Safety Monitoring Board, “The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT),” 2016-present. International Consensus on the use of High Flow Therapy (HFT) with Nasal Cannula, member, March 2018-present. Member of Data Safety Monitoring Board, “Facilitating Communication Study (FCS2),” 2019-present Member of Data Safety Monitoring Board, “Phase 2 RCT of low dose inhaled carbon monoxide in ARDS,” 2019-present Chair of Data Safety Monitoring Board, “Arrest Respiratory Failure Due to Pneumonia (ARREST Pneumonia) Trial”, NIH funded, MPIs J Levitt, E Festic, O Gajic, K Mahaffey, M Matthay, 2019-present Member of Data Safety Monitoring Board, “Impact of Resident Scheduling on Patient and Resident Outcomes (INCURS) Trial”, CIHR funded, MPIs D. Piqette and C. Parshuram, 2019-present

Daniel Weiss, MD PhD Chief Scientific Officer International Society for Cell and Gene Therapies 2014-present

Respiratory Tract Committee American Society for Cell and Gene Therapies 2003-present

Chair/Emeritus Chair ATS Stem Cell Working Group 2005-present

Editorships and Editorial Boards: Jason H.T. Bates, PhD DSc Deputy Editor, Journal of Applied Physiology

Charles Irvin, PD 2014 - present Editorial Board, COPD Journal C. Matthew Kinsey, MD, MPH 2016-present Journal of Bronchology and Interventional Pulmonology Editor for series “Epidemiology and Statistical Pearls for Interventional Pulmonologists”

Skyler Lentz, MD 2019- Present. Co-editor of online Emergency Medicine Blog. emDOCS.net

Matthew E. Poynter, PhD Editorial Board Member for the American Journal of Respiratory Cell and Molecular Biology

Renee Stapleton, MD PhD Murray & Nadel’s Textbook of Respiratory Medicine. Co-Editors: V. Courtney Broaddus, Lynn M. Schnapp, Joel D. Ernst, Talmadge E. King Jr, Stephen C. Lazarus, Renee D. Stapleton. Elsevier Saun- ders, Philadelphia, publication expected 2021.

Daniel Weiss, MD PhD Molecular Therapy 2008-present

146

American Journal of Respiratory and Cell Molecular Biology 2012-present Cytotherapy 2019-present

Study Sections and Federal Advisory Boards: Anne E. Dixon, MA, BM, BCh Member, VA Pulmonary Merit Review Study Section Ad hoc member NIH RIBT study Section Ad hoc Member, NHLBI, Special Emphasis Panel, ZHL1 CSR-S (M1). Stimulating Access to Research in Residency Transition Scholar (StARRTS), March 2020

Charles Irvin, PhD Chair, U01. R21 Review, NCATS, National Institutes of Health, 2019 Co-Chair, CTSA NCATS National Institutes of Health, 2019 Chair, INBRE Review, NIGMS, National Institutes of Health, 2019 Chair, U01. R21 Review, NCATS, National Institutes of Health, 2020 Chair, American Lung Association COVID-19 grants review, 2020

David Kaminsky, MD Research Grant Study Section Group B for American Lung Association

C. Matthew Kinsey, MD. MPH Development Therapeutics Study Section Appointed Member National Cancer Institute, 2020

Matthew E. Poynter, PhD Flight Attendant Medical Research Institute NIH Hypersensitivity, Allergies and Mucosal Immunology (HAMI) IMM-T57 Special Emphasis Panel NIAID Special Emphasis Panel, Immune Tolerance Network (2020/10 ZAI1 TC-I (S3) R) (07/28/2020)

Renee Stapleton, MD PhD Member of NIH Review Panel2020/01 ZRG1 SBIB-A (56) R. “Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R01 Clinical Trial Required),” September 2019. Member of NHLBI Clinical Trials Review Committee (CLTR, standing study section), June 2020-present

Daniel Weiss, MD PhD NIH/VA COVID Response Special Emphasis Panel, 2020 DOD, 2019 Canadian Cystic Fibrosis Foundation, 2019, 2020 Dutch Lung Research Foundation, 2020

Major Faculty Awards: Gilman Allen, MD ACP “Honor Your Mentor” Award, Nominated by Amy Teleron

Jason H.T. Bates, PhD DSc Solbert Permutt Trailblazer Award, Respiratory Structure & Function Assembly, American Thoracic Society Anne E. Dixon, MA, BM, BCh

147

American Thoracic Society Distinguished Achievement Award.

Charles Irvin, PhD Visiting Professor, University of Amsterdam, The Netherlands, 2019 Mentorship Award, Department of Medicine, LCOM, 2019 W. Fred Taylor (Inaugural Award) IDeA/EPSCOR Foundation, 2020

C. Matthew Kinsey, MD MPH Junior Researcher of the Year Award, 2019, University of Vermont Medical Group

Katelin Morrissette, MD Inducted into the UVM teaching academy

Renee Stapleton MD PhD Senior Researcher of the Year Award, 2019, University of Vermont Medical Center Zachary Weintraub, MD PACE Award. The program for adult care excellence in CF.

Grants – list all active by faculty member, PI Jason H.T. Bates, PhD DSc R01 HL130847 PI: Bates/Dixon 03/15/2016 – 02/29/2020 NIH/NHLBI

Non-allergic late-onset asthma of obesity: pathophysiology and therapy. The goal of this project is to determine how elevations in lung volume affect airways responsiveness and asthma control on obese subjects with the non-atopic form of obese asthma. Role: PI

T32 HL076122 PI: Poynter/Irvin 05/01/2019 – 04/30/2024 NIH/NHMBI Multidisciplinary Training in Lung Biology This training program for 4 predoctoral and 3 postdoctoral researchers seeks to train a group of collaborative and productive scientists to investigate the causes, diagnosis, and cures of debilitating lung diseases such as asthma, interstitial lung disease, cystic fibrosis, acute lung injury, and infections of the lung. Role: Co-PI

R01 HL133920 PI: Poynter/Dixon 08/15/2016 - 07/30/2021 NIH/NHLBI Obese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial Function The objective of this proposal is to investigate cells and mediators released from visceral adipose tissue of obese allergic asthmatics, and their effects on mitochondrial function. Role: co-investigator

U01 HL139466 PI: Suki/Bates 09/01/2018 – 08/31/2023 NIH/NIBIB A multi-scale computational model of the extracellular matrix of the lung The objective of this proposal is to develop computational models, based on experimental data of how pulmonary fibrosis develops over time, with a view to understanding how the histological phenotype arises as a result of mechanical stress. Role: Co-PI

148

R01 HL142702 PI: Bates/Nieman/Gaver 9/10/2018 – 06/30/2022 NIH/NHLBI Preserving epithelial barrier integrity in ventilator-induced lung injury. The objective of this proposal is to develop a quantitative mechanistic understanding of the mechanical processes involved in ventilator-induced lung injury, to encapsulate this understanding in mathematical/computational models, and to use this understanding to propose improved approaches to the ventilator management of patients with acute respiratory distress syndrome. Role: Co-PI

P20 GM125498 PI: Kirkpatrick 12/01/2018 – 11/30/2023 NIH/NIGMS Translational research to prevent and control global infectious diseases (Translational Global Infec- tious Diseases Research Center, TGIR) The goal of this proposal is to train a cadre of promising young faculty at the University of Vermont in research into the understanding and prevention of global infectious diseases. Dr. Bates is leader of a core in Predictive Computational and Mathematical Modeling. Role: Co-PI and Core Leader

Ryan Clouser, DO UVMMC Foundation Grant – Community Paramedice Pilot Project.

Anne E. Dixon, MA, BM, BCh Dixon PI: NIH R34 HL135361, 5/1/2017 – 04/30/2020 NIH/NHLBI (NCE) Trial of Roflumilast in Asthma Management (TRIM)

Dixon MPI: NIH R01HL133920 08/15/16-07/31/2021, Obese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial Function

Dixon MPI: NIH R01 HL130847 03/01/16 – 02/29/2020 (NCE) Non-Allergic Late-Onset Asthma of Obesity: Pathophysiology and Therapy

Dixon MPI: NIH R01 HL137268 08/15/17-05/30/2021 S-glutathionylation chemistry, glycolysis and obese allergic asthma

Dixon MPI, NIH R01HL136917 09/04/2018-07/31/2023 Mitochondrial Redox Perturbations in Obese Allergic Asthma

Dixon Co-I, NIH R01 HL138708 08/03/2017 – 06/30/2021 DUOX1 and mitochondria in obese asthma

Dixon Co-I 08/01/00-05/31/2021 American Lung Association Airways Clinical Research Center Network

Charles Irvin, PhD American Lung Association (Irvin) 07/01/1999 - 06/30/2021 Airways Clinical Research Center (ACRC) Role: Principal Investigator of the Northern New England Consortium (NNEC) ALA-ACRC

149

Major goal are to investigate the pathogenesis of asthma in the format of a multi-center network. I am the PI of the NNEC study site and we currently are recruiting applicants for both NIH sponsored studies and industry sponsored studies.

T32 HL076122, NIH/NHLBI (Irvin/Poynter) 04/01/2004 - 04/30/2024 Multidisciplinary Training in Lung Biology Role: MPI The major goal of this training grant is to produce outstanding, independent biomedical scientists who investigate the mechanisms, manifestations, preventions and cures for lung disorders. This grant supports both pre and postdoctoral fellows.

R35 HL135828 (Janssen-Heininger) 01/01/2017 - 12/31/2023 NIH/NHLBI S-glutathionylation chemistry in fibrotic lung remodeling Role: Co-Investigator The goal of this proposal is to understand the importance of the process of S-glutathionylation in patients with asthma or pulmonary fibrosis, and in mouse models of these diseases. The goal is to understand how this process of S-glutathionylation works, and whether the enzymes that regulate this process can be a target for more specific drugs. We believe that these questions are important for translation into clinical practice as we already have data with compounds that can be used clinically.

R01 HL137268 (van der Vliet/Dixon) 08/15/2017 - 05/30/2021 NIH/NHLBI S-glutathionylation chemistry, glycolysis and obese allergic asthma Role: Co-Investigator Obesity is a risk factor for the development of asthma, and obese asthmatics tend to have severe and poorly controlled disease. The underlying factors that contribute to increased disease severity in obese asthmatics are currently largely unknown. This proposal addresses whether changes in oxidant status are an important factor in obese asthma and whether oxidant-induced changes in glucose metabolism (glycolysis) contribute to disease severity in obese asthmatics.

R25 GM116701 04/01/2016 - 02/28/2021 NIH/NIGMS Fostering entrepreneurship in biomedical research Role: PI The goal of this training grant is to increase the entrepreneurship environment in biomedical research within the University of Vermont as well as other IDeA states (Maine, New Hampshire, Rhode Island, Puerto Rico and Alaska) by developing common courses and workshops.

UT2 GM130176 (Reder) 09/01/2018 - 08/31/2020 NIH/NIGMS Subcontract with Celdera Medical Role: Academic Co-PI DRIVEN: Accelerating Medical Entrepreneurship in the Northeast The goal of this grant is to establish a regional hub to facilitate investigators of the Northeast IDeA states to become successful entrepreneurs

C. Matthew Kinsey, MD MPH

150

Ongoing Research Support 1K23HL133476-01, NIH National Heart, Lung, and Blood Institute Kinsey, C. Matthew (PI) 09/01/16-06/30/21 CT Characteristics of Emphysema for Evaluation of Pulmonary Nodules This research focuses on leveraging the morphologic and vascular characteristics of emphysema to help determine if a lung nodule may be cancer.

Translational Medicine Pilot Award 2017, University of Vermont Medical Center Department of Medi- cine Kinsey, C. Matthew (PI) 07/01/17-06/30/20 A Computational Model for Adjuvant Cisplatin Based on CT and Tissue Features Delivery of intratumoral cisplatin directly into a tumor is currently performed in an unguided manner. Through this work we will develop a computational model based on CT features and tissue biopsy to understand the optimal dose and location for intratumoral cisplatin.

Skyler Lentz, MD Longitudinal epidemiologic investigation of post-hospitalization health care utilization among ICU survivors in Vermont Vermont Lung Center Pilot Award 07/01/2020-06/30/2021 PI: Renee Stapleton, MD, PhD Role: Co-investigator

Matthew E. Poynter, PhD 1 R01 HL142081 (Poynter) 04/01/2018 – 03/31/2022 NIH/NHLBI Ketone Body Supplementation in Obese Asthma Role: PI

R01-HL133920 (Poynter & Dixon) 08/15/2016 – 07/30/2021 NIH allergic asthma and the impact of weight loss on airway epithelial function Role: Co-PI

NDC 2777 (Kraft) 11/01/2017 – 12/31/2020 National Dairy Council Full-Fat Yogurt and Glucose Tolerance Role: Co-I

T32-HL076122 (Poynter & Irvin) 05/01/2019 - 04/30/2024 NIH/NHLBI Multidisciplinary Training in Lung Biology Role: Co-PI

2 R01 HL085646-09 (van der Vliet) 09/01/2017 -08/31/2022 NIH/NHLBI Dual Oxidase in Airway Epithelial Injury and Inflammation Role: Co-I

R01 HL138708 (van der Vliet) 08/03/2017-06/30/2021 NIH/NHLBI DUOX1 and Mitochondria in Obese Asthma Role: Co-I

151

R56 AG062105 (Dumas) 09/15/2019 - 08/31/2020 NIH/NIA Fatty Acid Effects on Brain Functioning in Normal Aging Role: Co-I

R01 HL122383-06 (Anathy) 05/01/2020 – 04/30/2024 NIH/NHLBI Endoplasmic reticulum stress signaling in allergen induced airway remodeling Role: Co-I

R01 HL143452 (Stapleton, Toth, Files, & Poynter) 09/15/2018-06/30/2022 NIH/NHLBI Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness (NEXIS- FLAME) Role: MPI

R03 AI151525 (Wargo) 4/23/2020-4/22/2022 NIH/NIAID Klebsiella pneumoniae pathogenesis in the obese lung Role: Co-I

Renee Stapleton, MD PhD R01 HL132887 4/01/2017-3/31/2022 NIH/NHLBI Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trial of Combined Cycle Ergome- try and Amino Acids in the ICU Role: Contact PI

R01 HL143452 09/15/2018-06/30/2022 NIH/NHLBI Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness (NEXIS- FLAME) Role: Contact PI

R01 AG050698 5/01/2016-2/28/2021 NIH/NIA Improving Palliative Care for Older Seriously Ill Hospitalized Patients and Their Families: A Ran- domized Trial of an Informed Assent Communication Intervention about CPR Role: PI

R42 AG059451 4/01/18-6/30/21 NIH/NIA Novel Arm Restraint for Critically Ill Patients to Reduce Immobility, Sedation, Agitation and Cogni- tive Impairment Role: Contact PI

R01 HL142093 4/01/2019-3/31/2023 NIH/NHLBI Therapeutic modulation of zinc for lung injury and mechanobiology Role: Co-Investigator

T32 HL076122 05/01/2019-04/30/2024 NIH/NHLBI Multidisciplinary Training in Lung Biology

152

Role: Co-Director

Charlotte Teneback, MD Cystic Fibrosis Therapeutic Development Network 3/2/2020-3/1/2021 CF Therapeutic Development Center Award Co-PI (with Thomas Lahiri MD)

Cystic Fibrosis Center Grant 7/1/2020-6/30/2021 Adult Program Center grant

Cystic Fibrosis Lung Transplant Transition Learning and Leadership Collaborative 3 June 2020-October 2021

Calithera Biosciences CX-280-202: A phase 1b randomized, double-blind placebo-controlled trial to evaluate the safety of CB280 in Patient with Cystic fibrosis.

Daniel Weiss, MD PhD R21 EB024329 (DJ Weiss, PI) 02/15/2017-07/31/2020 NIH/NHLBI Decellularized Avian Lungs for Use in Pulmonary Therapeutics The goals of this project are to fully characterize de- and recellularization of representative avian lung, develop initial technologies for novel Avian Lung Assist Devices (ALAD) incorporating recellularized avian lungs that could be potentially utilized for independent, portable or implantable lung assist devices.

R13 HL149436 (DJ Weiss, PI) 07/04/2019-06/30/2020 NIH/NHLBI Optimization of MSC Based Cell Therapies for CF The principle goals of the proposed meeting, “Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases” are to convene the relevant experts and up and coming junior investigators to share and debate recent developments in this rapidly moving and exciting field with a specific goal to formulate basic, translational, and clinical research directions.

SPARK, UVM (DJ Weiss/Adam Jakus, Dimensions Inc.) 07/01/2018-06/30/2020 Development of novel lung bioinks Project goals are to test the mechanical and biochemical properties of lung-specific ECM-derived materials and evaluate optimized lung ECM-origin gels and patches in pre-clinical models of lung injury.

WEISS18P0 (Weiss) 04/01/2019-03/31/2021 Cystic Fibrosis Foundation Role of Glycoproteins in Lung Recellularization The goals for this proposal are to systematically analyze key matrikine binding and activation patterns to specific individual HS, CS and DS in decellularized human lungs, to systematically determine matrikine dependent and independent effects of individual HS, CS and DS chains on representative lung cell growth and differentiation and to determine matrikine-dependent and independent effects of systematic repletion of decellularized normal or dis- eased human lung ECM with key HS, CS and/or DS functional groups on cell growth and differentiation.

PRMRP Expansion Award (Weiss) 07/01/2019-06/30/2022 Department of Defense Clinical Development of a Novel Pleural and Tracheal Sealant

153

The goals of this proposal are to define optimal manufacturing of the ALG-MA-DA patch formulations, optimal ster- ilization, preservation and storage conditions to facilitate off the shelf use, long term efficacy and safety in longitudinal small (rate) and large (pig) models of adult pleural injury and adult and pediatric tracheal injuries and assess short term efficacy in an ex vivo pleural injury model in human lungs obtained at autopsy (UVM).

S10 OD026976 (Weiss) 08/01/2019-07/31/2020 NIH Zeta View TWIN Laser Nanoparticle Tracking Analyzer The goal of this proposal is to obtain a state-of-the-art ZetaView TWIN Laser Nanoparticle Tracking Analyzer (NTA) device at the University of Vermont (UVM).

Publications-peer reviewed, chapters, etc. Abreu SC, Enes SR, Dearbron J, Goodwin M, Coffey A, Borg ZD, dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, Weiss DJ. Lung Inflamma- tory Environments Differentially Alter Mesenchymal Stromal Cell Behavior. Am J Physiol Lung Cell Mol Physiol. 2019 Dec 1;317(6):L823-L831.

Badlam JB, Badesch D, Brittain E, Cordell S, Ding T, Fox K, Hemnes A, Loyd J, Pugh M, Robbins I, Yu C, Austin ED. Sex hormone exposure and reproductive factors in pulmonary arterial hypertension: a case-control study. Pulm Circ. 2020 Feb;10(1):1-9. PMID: 32166018.

Bates JHT, Doty EA, and Kinsey CM. Analyzing complex medical image information: convolution versus wavelets in a neural net. In: Embracing Complexity in Health. The Transformation of Science, Practice, and Policy. J.P. Sturmberg, Ed. Springer Nature Switzerland, 2019.

Bates JHT. Theory and measurement of respiratory resistance. In: Cotes’ Lung Function. 7th edition. R.L. Maynard, S.J. Pearce, B. Nemery, P.D. Wagner, and B.G. Cooper, Eds. Wiley, pp. 217-229, 2020.

Beigel JH, Aga E, Elie-Turenne MC, Cho J, Tebas P, Clark CL, Metcalf JP, Ozment C, Raviprakash K, Beeler J, Holley HP Jr, Warner S, Chorley C, Lane HC, Hughes MD, Davey RT Jr; IRC005 Study Team. Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial. Lancet Respir Med 2019;7:941-950.

Borger V; Weiss DJ; Anderson JD; Borras FE; Bussolati B; Carter DRF; Dominici M; Falcon-Perez JM; Gimona M; Hill AF; Hoffman AM; de Kleijn D; Levine BL; Lim R; Lotvall J; Mitsialis SA; Monguio-Tortajada M; Muraca M; Nieuwland R; Nowocin A; O'Driscoll L; Ortiz LA; Phinney DG; Reischl I; Rohde E; Sanzenbacher R; Thery C; Toh WS; Witwer KW; Lim SK; Giebel B. ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19. Cytotherapy. 2020 May 16.

Bose S, Bime C, Henderson RJ, Blake KV, Castro M, DiMango E, Hanania NA, Holbrook JT, Irvin CG, Kraft M, Peters SP, Reibman J, Sugar EA, Sumino K, Wise RA, Rogers L; Biomarkers of type 2 airway inflammation as predictors of loss of asthma control during step-down therapy for well-controlled disease: The Long Acting Beta Agonist Step-down Study (LASST). American Lung Association Airways Clinical Research Centers.J Allergy Clin Immunol Pract. 2020 Jul 18:S2213-2198(20)30714-5. doi: 10.1016/j.jaip.2020.06.067. Online ahead of print.PMID: 32693214

Bou Jawde S, Takahashi A, Bates JHT, and Suki B. An Analytical Model for Estimating Alveolar Wall Elastic Moduli from Tissue Stress-Strain Curves. Frontiers in Physiology. 11: article 121, 2020. doi: 10.3389/fphys.2020.00121

154

Bou Jawde S, Walkey AJ, Majumdar A, O’Connor GT, Smith BJ, Bates JHT, Lutchen KR, and Suki B. Tracking respiratory mechanics around natural breathing rates via variable ventilation. Scientific Reports. Article number: 7622, 2020. Doi: 10.1038/s41598-020-63663-8.

Cancio M, Ciccocioppo R, Rocco PRM, Levine BL, Bronte V, Bollard CM, Weiss D, Boelens JJ, Hanley P. Emerging trends in COVID-19 treatment: learning from inflammatory conditions associated with cellular therapies. Cyto- therapy. 2020 May 7:S1465-3249(20)30657-5. doi: 10.1016/j.jcyt.2020.04.100. Online ahead of print.PMID: 32565132

Chapman DG, Casey DT, Ather JL, Aliyeva M, Daphtary N, Lahue HG, and der Velden JL, Janssen Heininger YMW, Irvin CG. The Effect of Flavored E-Cigarettes on Murinbe Allergic airways Disease.Sci Rep 2019

Chia SB, Elko EA, Aboushousha, Manuel AM, van de Wetering C, Druso JE, van der Velden J, Seward DJ, Anathy V, Irvin CG, Lam YW, van der Vliet A, Janssen-Heininger Y. Dysregulation ofglutaredoxin/S-glutathionylation redox axis in lung diseases. Am J Physiol Cell Physiol. 2019 PMID: 31693398

Criner GJ, Delage A, Voelker K, Hogarth DK, Majid A, Zgoda M, Lazarus DR, Casal R, Benzaquen SB, Holladay RC, Wellikoff A, Calero K, Rumbak MJ, Branca PR, Abu-Hijleh M, Mallea JM, Kalhan R, Sachdeva A, Kinsey CM, et al. Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE): A Multicenter, Open-Label, Randomized, Controlled Trial. Am J Resp Crit Care Med. (2019). PMID 31365298

Cuthbertson L., Walker A, Oliver A; Rogers G; Rivett D; Hampton T, Ashare A; Elborn S; De Soyza A; Carroll A; Hoffman L; Lanyon C; Moskowitz S; O'Toole G; Parkhill J; Planet P; Teneback C; Tunney M; Zuckerman J, Bruce K; and van der Gast C. Lung Function and Microbiota in Cystic Fibrosis. Microbiome 8, 45 (2020) de Castro LL, Lopes-Pacheco M, Weiss DJ, Cruz FF, Rocco PRM. Current understanding of the immunosuppres- sive properties of mesenchymal stromal cells. J Mol Med (Berl). 2019 May;97(5):605-618. doi: 10.1007/s00109- 019-01776-y. Epub 2019 Mar 22. PMID: 30903229.

Dixon AE & F. Holguin. Diet and Metabolism in the evolution of asthma and obesity. Clin Chest Med 2019 40: 97-106 PMCID: PMC6355154

Dixon AE, Peters U, Walsh R, Daphtary N, MacLean ES, Hodgdon K, Kaminsky DAK & Bates JHT. Physiological signature of late-onset asthma of obesity, ERJ Open Research, accepted for publication

Dransfield MT, Voelker H, Bhatt SP, Brenner K, Casaburi R, Come CE, Cooper JAD, Criner GJ, Curtis JL, Han MK, Hatipoğlu U, Helgeson ES, Jain VV, Kalhan R, Kaminsky D, Kaner R, Kunisaki KM, Lambert AA, Lammi MR, Lindberg S, Make BJ, Martinez FJ, McEvoy C, Panos RJ, Reed RM, Scanlon PD, Sciurba FC, Smith A, Sriram PS, Stringer WW, Weingarten JA, Wells JM, Westfall E, Lazarus SC, Connett JE; BLOCK COPD Trial Group.Metoprolol for the Pre- vention of Acute Exacerbations of COPD. N Engl J Med. 2019 Dec 12;381(24):2304-2314. doi: 10.1056/NEJMoa1908142. Epub 2019 Oct 20. PMID: 31633896 Clinical Trial.

Ducomb EA, Kinsey CM. “Taking the Air Out of Nebulized Lidocaine.” Chest. 157(1):5-6. (2020). PMID 31689144

Ducomb EA, Tonellli BA, Tuo Y, Cole BF, Mori V, Bates JHT, Washko GR, San José Estépar R, Kinsey CM. “Evidence for Expanding Invasive Mediastinal Staging for Peripheral T1 Lung Tumors” Chest. 2020 Jun 26;. doi: 10.1016/j.chest.2020.05.607. [Epub ahead of print]. PMID: 32599066

155

Enes SR, Weiss DJ. Cell Therapy for Lung Disease: Current Status and Future Prospects. Current Stem Cell Re- ports,1-10. DOI: 10.1007/s40778-020-00171-5.

Farkas JD, Long B, Koyfman A, Menson K. BRASH Syndrome: Bradycardia, Renal Failure, AV Blockade, Shock, and Hyperkalemia [published online ahead of print, 2020 Jun 18]. J Emerg Med. 2020;S0736-4679(20)30399-1. doi:10.1016/j.jemermed.2020.05.001

Farkas JD. The complete blood count to diagnose septic shock. J Thorac Dis. 2020;12(Suppl 1):S16-S21. doi:10.21037/jtd.2019.12.63

Folch EE, Mahajan AK, Oberg CL, Maldonado F, Toloza E, Krimsky WS, Oh S, Bowling MR, Benzaquen S, Kinsey CM, (25 additional authors). “Standardized Definitions of Bleeding After Transbronchial Lung Biopsy: A Delphi Consensus Statement from the Nashville Working Group.” Chest. S0012-3692(20)30272-5. PMID:32067944

Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, Hallstrand TS, Kaminsky DA, McCar- thy K, McCormack MC, Oropez CE, Rosenfeld M, Stanojevic S, Swanney MP, Thompson BR. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med. 2019 Oct 15;200(8):e70-e88. doi: 10.1164/rccm.201908-1590ST. PMID: 31613151

Guigni BA, van der Velden J, Kinsey CM, Carson JA, Toth MJ. “Effects of Conditioned Media from Murine Lung Cancer Cells and Human Tumor Cells on Cultured Myotubes.” Am J Physiol Endocrinol Metab. 318(1):E22-E32. (2020). PMID: 31689144

Haynes JM, Kaminsky DA, Stanojevic S, Ruppel GL. Pulmonary Function Reference Equations: A Brief History to Explain All the Confusion. Respir Care. 2020 Jul;65(7):1030-1038. doi: 10.4187/respcare.07188. Epub 2020 Mar 10. PMID: 32156791 Review.

Haynes JM, Ruppel GL, Kaminsky DA. Weight-based reference equations for the 6-min walk test can be mislead- ing in obese patients. ERJ Open Res. 2020 May 11;6(2):00028-2020. doi: 10.1183/23120541.00028-2020. eCol- lection 2020 Apr. PMID: 32420311 Free PMC article.

Heyland DK, Needham DM, Day AG, Clarke J, Hough CL, Files DC, Mourtzakis M, Deutz NEP, Stapleton RD. Nutri- tion and Exercise in Critical Illness Trial (NEXIS Trial): A protocol of a multi-centered, randomized controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. BMJ Open 2019 9: p. e027893-e027893.

Ikonomou L and Weiss DJ. Turning the tide on unproven cell-based interventions. Chest. 2020 Apr;157(4):774- 775.

Ikonomou L, Wagner DE, Turner L, Weiss DJ. Translating Basic Research into Safe and Effective Cell-based Treat- ments for Respiratory Diseases. Ann Am Thorac Soc. 2019 Jun;16(6):657-668. doi: 10.1513/AnnalsATS.201812- 890CME. PMID: 30917290.

Kaminsky DA, Chapman DG, Holbrook JT, Henderson R, Sugar EA, Matronade J, Teague WWG, Busk M, Sumino K, Dixon AE, Wise RA & CG Irvin, Older Age and Obesity are Associated with Increased Airway Closure in Re- sponse to Methacholine in Patients with Asthma, Respirology. 2019 Jul;24(7):638-645. PMCID: PMC6525043

156

Kaminsky DA, Daphtary N, Estepar RSJ, Ashikaga T, Mikulic L, Klein J, Kinsey CM.Ventilation Heterogeneity and Its Association with Nodule Formation Among Participants in the National Lung Screening Trial-A Preliminary Investigation. Acad Radiol. 2020 May;27(5):630-635. doi: 10.1016/j.acra.2019.07.024. Epub 2019 Aug 27. PMID: 31471206 Free PMC article.

Kaminsky DA. What Is a Significant Bronchodilator Response? Ann Am Thorac Soc. 2019 Dec;16(12):1495-1497. doi: 10.1513/AnnalsATS.201908-604ED. PMID: 31774318 No abstract available.

Khoury M, Cuenca J, Cruz FF, Figueroa FE, Rocco PRM, Weiss DJ. Current Status of Cell-Based Therapies for Respiratory Virus Infections. European Respiratory Journal, in press 2020.

Khoury M, Rocco PRM, Phinney DG, Krampera M, Martin I, Viswanathan S, Nolta JA, LeBlanc K, Galipeau J, Weiss DJ. Cell-Based Therapies for COVID-19: Proper Clinical Investigations are Essential. Cytotherapy, in press 2020.

King GG, Bates J, Berger KI, Calverley P, de Melo PL, Dellacà RL, Farré R, Hall GL, Ioan I, Irvin CG, Kaczka DW, Kaminsky DA, Kurosawa H, Lombardi E, Maksym GN, Marchal F, Oppenheimer BW, Simpson SJ, Thamrin C, van den Berge M, Oostveen E. Technical standards for respiratory oscillometry. Eur Respir J. 2020 Feb 27;55(2):1900753. doi: 10.1183/13993003.00753-2019. Print 2020 Feb. PMID: 31772002

Kinsey CM, San José Estépar R, Bates JHT, Cole BF, Washko GR, Jantz M, Mehta H. “Tumor Density is Associated with Response to Endobronchial Ultrasound-Guided Transbronchial Needle Injection of Cisplatin”. Accepted Journal of Thoracic Disease.

Lentz S, Grossman A, Koyfman A, Long B, High-Risk Airway Management in the Emergency Department: Diseases and Approaches Part I, The Journal of Emergency Medicine (2020), doi: https://doi.org/10.1016/j.jemermed.2020.05.008. PMID: 32563613

Lentz S, Grossman A, Koyfman A, Long B, High-Risk Airway Management in the Emergency Department: Diseases and Approaches Part II. The Journal of Emergency Medicine (2020), DOI: https://doi.org/10.1016/j.jemermed.2020.05.009 PMID: 32591298

Lentz S, Roginski M, Montrief T, Ramzy M, Gottlieb M, Long B. Initial Emergency Department Mechanical Venti- lation Strategies in COVID-19 Related Hypoxemic Respiratory Failure. Am J Emerg Med (2020), DOI: https://doi.org/10.1016/j.ajem.2020.06.082

Lim SK; Giebel B; Weiss DJ; Witwer KW; Rohde E. Re: "Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19" by Sengupta et al. In press, Stem Cells & Development. 2020 Jun 10.

Long B, Lentz S, Koyfman A, Gottlieb M. Evaluation and management of the critically ill adult asthmatic in the emergency department setting [published online ahead of print, 2020 Mar 19]. Am J Emerg Med. 2020;S0735- 6757(20)30171-6. doi:10.1016/j.ajem.2020.03.029. PMID: 32222313

M. Mellenthin, S. Seong, G. Roy, E. Bartolák-Suki, K. Hamlington, J.H.T. Bates, and B. Smith. Using Injury Cost Functions from a Predictive Single Compartment Model to Assess the Severity of Mechanical Ventilator Induced Lung Injuries. Journal of Applied Physiology. 127: 58–70, 2019.

Madenspacher JH, Morrell ED, Gowdy KM, McDonald JG, Thompson BM, Muse G, Martinez J, Thomas S, Mika- cenic C, Nick JA, Abraham E, Garantziotis S, Stapleton RD, Meacham JM, Thomassen MJ, Janssen WJ, Cook D,

157

Wurfel MM, Fessler MB. Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation. JCI Insight 2020;5(11):137189. doi: 10.1172/jci.insight.137189.

Mahajan AK, Ost DE, Cole BF, Kinsey CM. Applications of Non-inferiority Trials in Interventional Pulmonology. J Bronchology Interv Pulmonol. 26(1):6-9.(2019). PMID: 30562280

Meservey AJ, Burton MC, Priest J, Teneback CT & Dixon AE. Risk of readmission and mortality following hospitalization with hypercapnic respiratory failure. Lung 2020;198(1):121-134.

Messervey AJ, Burton MC, Priest J, Teneback CC, Dixon A. Risk of Readmission and Mortality Following Hospital- ization with Hypercapnic Respiratory Failure. Lung, 198: 121-134, 2020.

Mori V, Roy GS, Bates JHT, Kinsey CM. “Cisplatin Pharmacodynamics Following Endobronchial Ultrasound Guided Transbronchial Needle Injection (EBUS-TBNI)”.. Scientific Reports. 9(1): 6819 (2019). PMID 31048709

Morrell E, Bhatraju PK, Mikacenic C, Radella F, Manicone AM, Stapleton RD, Wurfel MM, Gharib SA. Alveolar Macrophage Transcriptional Programs are Associated with Ventilator-Free Days in Acute Respiratory Distress Syndrome Am J Respir Crit Care Med 2019;200:732-741.

Nakada EM, Bhakta NR, Korwin-Mihavics BR, Kumar A, Chamberlain N, Bruno SR, Chapman DG, Hoffman SM, Daphtary N, Aliyeva M, Irvin CG, Dixon AE, Woodruff PG, Amin S, Poynter ME, Desai DH & Anathy V. Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transduc- ers, JCI Insight. 2019;4(9):e98101

Nguyen HB, Thomson C, Jarjour NN, Dixon AE, Liesching TN, Schnapp LM, Madison JM, Murin S, Glenny R, Ka- minski N; Leading Change and Negotiation Strategies for Division Leaders in Clinical Medicine. Chest 2019; 156 (6): 1246-1253.

Parikh R, Bates JHT, Poynter ME, Suratt BT, Heyland DK Parsons PE, Kien CL, Crain KL, Martin J, Garudathri J, and Stapleton R. Pharmacokinetics of Omega-3 Fatty Acids in Patients with Severe Sepsis Compared with Healthy Volunteers: A Prospective Cohort Study. Clinical Nutrition. 39: 958-965, 2020.

Parikh R, Patel S, Parikh R, Mehta T, Stapleton RD. Burden of Respiratory Complications on 30-Day Unplanned Hospital Readmission in Patients with Generalized Convulsive Epilepsy and Status Epilepticus: A Nationwide Analysis. Neurology: Clinical Practice 2019;9:408-416.

Park HE, Gasek N, Hwang J, Weiss DJ, Lee PC. Effect of temperature on gelation and cross-linking of gelatin methacryloyl for biomedical applications. Physics of Fluids.32:3, DOI: 10.1063/1.5144896.

Peters U, Subramanian M, Chapman DG, Kaminsky DA, Irvin CG, Wise RA, et al. BMI but not central obesity predisposes to airway closure during bronchoconstriction. Respirology. 2019;24(6):543-50.PMID: 30694011

Pope T, Bennett J, Carson S, Cederquist L, Cohen A, DeMartino ES, Godfrey D, Goodman-Crews P, Kapp M, Lo B, Magnus D, Reinke L, Shirley J, Siegel MD, Stapleton RD, Sudore RL, Tarzian A, Thornton D, Wicclair M, Widera E, and White D on behalf of the American Thoracic Society ad hoc Committee on Medical Decision Making for Unrepresented Patients. Making Medical Treatment Decisions for Unrepresented Patients in the ICU: An Official ATS/AGS Policy Statement. Am J Respir Crit Care Med. 2020 May 15;201(10):1182-1192.

158

Pouliot RA; Young BM; Link PA; Park HE; Kahn AR; Shankar K; Schneck MB; Weiss DJ; Heise RL. Porcine Lung- Derived Extracellular Matrix Hydrogel Properties Are Dependent on Pepsin Digestion Time. Tissue Engineering - Part C: Methods. 26(6):332-346, 2020 Jun.

Rinne ST, Swarmy L, Anderson E, Shah T, Dixon AE, Kaminsky N, Borok Z & CC Thomson. Perspectives on burnout from Pulmonary, Critical Care and Sleep Medicine Division Directors, AJRCCM 2020 201 (1): 111-114.

Rola P, Farkas J, Spiegel R, Kyle-Sidell C, Weingart S, Duggan L, Garrone M, Thomas A. Rethinking the early intubation pardigm of COVID-19: time to change gears? Clin Exp Emerg Med. 2020;7(2):78-80. Published online June 10, 2020. DOI: https://doi.org/10.15441/ceem.20.043

Ryan AL, Ikonomou L, Atarod S, Bölükbas DA, Collins J, Freishtat R, Hawkins F, Gilpin SE, Uhl FE, Uriarte JJ, Weiss DJ, Wagner DE. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 Oct;61(4):429-439. doi: 10.1165/rcmb.2019-0286ST.

Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Proschan M, Aggarwal NR, Reineck LA. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. Am J Respir Crit Care Med 2020 Mar 9. doi: 10.1164/ rccm.201908-1595WS.

Silva JD, de Castro LL, Braga CL, Oliveira GP, Trivelin SA, Barbosa-Junior CM, Morales MM, Dos Santos CC, Weiss DJ, Lopes-Pacheco M, Cruz FF, Rocco PRM. Mesenchymal Stromal Cells Are More Effective Than Their Extracel- lular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology. Stem Cells Int. 2019 Aug 21;2019:8262849. doi: 10.1155/2019/8262849. eCollection 2019. PMID: 31531026.

Silva JD, Lopes-Pacheco M, de Castro LL, Kitoko JZ, Trivelin SA, Amorim NR, Capelozzi VL, Morales MM, Gutfilen B, de Souza SAL, Weiss DJ, Diaz BL, Rocco PRM. Eicosapentaenoic acid potentiates the therapeutic effects of adipose tissue-derived mesenchymal stromal cells on lung and distal organ injury in experimental sepsis. Stem Cell Res Ther. 2019 Aug 23;10(1):264. doi: 10.1186/s13287-019-1365-z. PMID: 31443678.

Silva LHA; Silva MC; Vieira JB; Lima ECD; Silva RC; Weiss DJ; Morales MM; Cruz FF; Rocco PRM. Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis. In press, Stem Cells Translational Medicine, June 2020.

Siuba MT, Carroll CL, Farkas JD, Olusanya S, Baker K, and Gajic O. The Zentensivist Manifesto. Defining the Art of Critical Care. ATS Scholar. 2020. https://doi.org/10.34197/ats-scholar.2020-0019PS. https://www.atsjour- nals.org/doi/pdf/10.34197/ats-scholar.2020-0019PS

Siuba MT, Farkas JD. Against Another Nonspecific Marker of Perfusion. Ann Am Thorac Soc. 2019;16(10):1334- 1335. doi:10.1513/AnnalsATS.201905-415LE

Stapleton RD, Heyland DK. Glycemic control and intensive insulin therapy in critical illness. Up To Date online version 16.3. 2007-present. Last updated May 2018. Section Editors Polly E. Parsons MD and Adrienne G. Ran- dolph MD MSc; Deputy Editor Kevin C. Wilson MD. Website: http://www.uptodate.com/online/content/topic.do?topicKey=cc_medi/13045&selectedTitle=1~150&source=search_result

159

Tharp WG, Murphy S, Breidenstein MW, Love C, Booms A, Rafferty MN, Friend AF, Perrapato S, Ahern TP, Dixon AE, Bates JHT, Bender SP Body Habitus and Dynamic Surgical Conditions Independently Impair Pulmonary Me- chanics during Robotic Assisted Laparoscopic Surgery: A Cross-Sectional Study, Anesthesiology, Online ahead of print.

Thwe, P.W., Fritz, D.I., Snyder, J.P., Smith, P.R., Curtis, K.D., O'Donnell, A., Galasso, N.A., Sepaniac, L.A., Adamik, B.J., Hoyt, L.R., Rodriguez, P.D., Hogan, T.C., Schmidt, A.F., Poynter, M.E., and E. Amiel. Syk-dependent glycolytic reprogramming in dendritic cells regulates IL-1β production to β-glucan ligands in a TLR-independent manner. Journal of Leukocyte Biology, 2019 Sep 11. doi: 10.1002/JLB.3A0819-207RR. PMC6883127.

Uhl FE, Zhang F, Pouliot RA, Uriarte JJ, Rolandsson Enes S, Han X, Ouyang Y, Xia K, Westergren-Thorsson G, Malmström A, Hallgren O, Linhardt RJ, Weiss DJ. Functional role of glycosaminoglycans in decellularized lung extracellular matrix. Acta Biomater. 2020 Jan 15;102:231-246. van de Wetering C, Aboushousha R, Manuel AM, Chia SB, Erickson C, MacPherson MB, van der Velden JL, Anathy V, Dixon AE, Irvin CG, Poynter ME, van der Vliet A, Wouters EFM, Reynaert NL, Janssen-Heininger YMW. Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease. J Immunol. 2020 Feb 15;204(4):763-774. PMCID: PMC6994838 van de Wetering, C., Aboushousha, R., Manuel, A.M., Chia, S.B., Erickson, C., MacPherson, M.B., van der Velden, J.L., Anathy, V., Dixon, A.E., Irvin, C.G., Poynter, M.E., van der Vliet, A., Wouters, E.F.M., Reynaert, N.L., and Y.M.W. Janssen-Heininger. Pyruvate kinase M2 promotes expression of proinflammatory mediators in house dust mite-induced allergic airways disease. Journal of Immunology, 204(4):763-774 (2020). PMC6994838. van der Velden JL, Alcorn JF, Chapman DG, Lundblad LKA, Irvin CG, Davis RJ, Butnor K, Janssen-Heininger YMW. Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models. PLoS One. 2020 Jan 14;15(1):e0226904. doi: 10.1371/journal.pone.0226904. eCollection 2020.PMID: 31935227

Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney AM, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alfasadi HN, Hoff- man ET, Weiss DJ, Firth AL. Technological Advances in Study of Lung Regenerative Medicine: Perspective from the 2019 Vermont Lung Stem Cell Conference. Cytotherapy, in press 2020.

Wahidi MM, Lamb C, Murgu S, Musani A, Shojaee S, Sachdeva A, Maldonado F, Mahmood K, Kinsey CM, Sethi S, Mahajan A, Majid A, Keyes C, Alraiyes AH, Sung A, Hsia D, Eapen G. American Association for Bronchology and Interventional Pulmonology (AABIP) Statement on the Use of Bronchoscopy and Respiratory Specimen Collec- tion in Patients with Suspected or Confirmed COVID-19 Infection. J. Bronchology Interv Pulmonol. 18:10.1097 (2020). PMID: 32195687

Weiss DJ, English K, Krasnodembskaya A, Isaza-Correa JM, Hawthorne IJ, Mahon BP. The Necrobiology of Mes- enchymal Stromal Cells Affects Therapeutic Efficacy. Front Immunol. 2019 Jun 4;10:1228. doi: 10.3389/fimmu.2019.01228. eCollection 2019. Review. PMID: 31214185.

Wernerman J, Christopher KB, Annane D, Casaer MP, Coopersmith CM, Deane AM, De Waele E, Elke G, Ichai C, Karvellas C, McClave SA, Oudemans-van Straaten HM, Rooyackers O, Stapleton RD, Takala J, van Zanten ARH, Wischmeyer P, Preiser J-C, Vncent J-L. Metabolic support in the critically ill: A consensus of 19. Crit Care 2019;23:318. doi: 10.1186/s13054-019-2597-0.

160

Wilson KC, Kaminsky DA, Michaud G, Sharma S, Nici L, Folz RJ, Barjaktarevic I, Bhakta NR, Cheng G, Chupp GL, Cole A, Dixon AE, Finigan JH, Graham B, Hallstrand TS, Haynes J, Hankinson J, MacIntyre N, Mandel J, McCarthy K, McCormack M, Patil SP, Rosenfeld M, Senitko M, Sethi S, Swenson ER, Stanojevic S, Teodorescu M, Weiner DJ, Wiener RS, Powell CA. Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens: From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force. Ann Am Thorac Soc. 2020 Jul 14. doi: 10.1513/AnnalsATS.202005-514ST. Online ahead of print. PMID: 32663071

Witwer KW, Van Balkom BWM, Bruno S, Choo A, Dominici M, Gimona M, Hill AF, De Kleijn D, Koh M, Lai RC, Mitsialis SA, Ortiz LA, Rohde E, Asada T, Toh WS, Weiss DJ, Zheng L, Giebel B, Lim SK. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J Extracell Vesicles. 2019 Apr 29;8(1):1609206. doi: 10.1080/20013078.2019.1609206. PMID: 31069028.

Chapter:

Dixon AE: Practical Considerations in the management of obesity associated asthma, in “Difficult to Treat Asthma”, Eds Khurana A & F. Holguin, 2019, Humana Press

Dixon AE & S Peters, Obesity and asthma, in Murray and Nadel 2019 (accepted)

Thompson B, Irvin CG Chapter 42 Development, Structure, and Physiology in Normal Lung and in Asthma In: Middleton’s Allergy Principles and Practice 9th Ed, Eds Burks AW et al Elsevier New York, 2020

Lentz S, Atchinson P, Roginski M. Chapter 29B: Mechanical Ventilation. 9th ed (2019). Tintinalli, Ma, Yealy, Meck- ler, Stapczynski, Cline, and Thomas. Tintinalli’s Emergency Medicine: A Comprehensive Study Guide (pp. 190- 193). McGraw-Hill Education

Editorial:

Irvin CG. The Flow-Volume Loop: Always an Inspiration! COPD. 2020 Jun;17(3):227-229. doi: 10.1080/15412555.2020.1758050. Epub 2020 Jun 8.PMID: 32506952

Murray & Nadel’s Textbook of Respiratory Medicine. Co-Editors: V. Courtney Broaddus, Lynn M. Schnapp, Joel D. Ernst, Talmadge E. King Jr, Stephen C. Lazarus, Renee D. Stapleton. Elsevier Saunders, Philadelphia, publication expected 2021.

Morrissette KM, Stapleton RD. Mounting clarity on enteral feeding in critically ill patients. Am J Respir Crit Care Med 2020;201:758-760.

Antkowiak MC, Parsons PE, Stapleton RD. Slow Progress toward Gender Equality in Critical Care Medicine. Am J Respir Crit Care Med 2020;201:763-764.

Curtis JR, Kross EK, Stapleton RD. The Importance of Addressing Advance Care Planning and Decisions about Do- Not-Resuscitate Orders during Novel Coronavirus 2019 (COVID-19). JAMA 2020 Mar 27. doi: 10.1001/jama.2020.4894.

Non-peer reviewed publications:

161

Lentz S, Ravera J. “Tips, Tricks and Pitfalls in the Intubated Child.” Emergency Physicians Monthly, 2019 August; 26(3): 8. https://epmonthly.com/article/tips-tricks-and-pitfalls-in-the-intubated-child/

Daly M, Lentz S. Diagnosing Cardiogenic Shock in the ED. Practice Updates, 2020 http://www.emdocs.net/diagnosing-cardiogenic-shock-in-the-ed/ Editor of digital companion to “Tintinelli’s Emergency Medicine, 9th edition” textbook. Chapter 33- Cardiac pacing and devices (In Progress) K. Morrissette

162

Division of Rheumatology and Clinical Immunology Bonita Libman, M.D., Division Chief http://www.med.uvm.edu/medicine/rheumatology

The members of the Division of Rheumatology and Clinical Immunology provide high quality patient care to residents of Vermont, up-state New York and other contiguous communities, teach UVM Medical Center resident physicians and UVM College of Medicine medical students, and perform both bench and clinical research. Our faculty consists of seven physicians, a clinician pharmacist and a nurse practitioner. Over the past 12 months, the Rheumatology Division saw over 11,000 patients, generating more than 17,000 work RVUs. We provide point of care diagnostic and procedural (guided injections) musculoskeletal ultrasound that is integrated with rheumatology care. We participate in an interdisciplinary metabolic bone clinic in addition to our rheumatology services. We cover inpatient consults at the University of Vermont Medical Center on a 24-7 basis.

Our fully accredited rheumatology fellowship program accepts one new fellow annually in an increasingly competitive match. Our fellows receive musculoskeletal ultrasound training and participate in the USSONAR program. The internal medicine residency program continues to participate in an outpatient rheumatology rotation where residents see rheumatology patients with all of the faculty, thus experiencing a variety of practice styles. Faculty and fellows teach various rheumatology topics during the annual Internal Medicine Academic Half Day. Medical students complete one month elective rotations in our outpatient clinic. Each year we participate in the Vermont Integrated Curriculum Connections course teaching 2nd year medical students rheumatology and musculoskeletal physical examination skills.

Our faculty engage in clinical research including JAK kinase inhibition in giant cell arteritis, thyroid antibodies in rheumatology patients with a positive ANA, and chronic low back pain exercise. We are actively engaged in QI projects such as VCHIP transition of care program, prevention of glucocorticoid induced osteoporosis, pneumococcal vaccination in patients on biological drugs, and patient education regarding DMARD therapy. The latter two QI projects resulted in (respectively) an abstract and a publication. We continue to collaborate with the Division of Immunobiology on research in molecular physiology in rheumatoid arthritis and lupus patients.

Faculty

Narandra Bethina, M.D. Associate Professor of Medicine Associate Program Director, Rheumatology Fellowship Training Program Director, Division of Rheumatology Musculoskeletal Ultrasound Clinic  Rheumatoid Arthritis  Psoriatic Arthritis  Scleroderma  Sjogren’s Syndrome  Gout

163

 Autoimmune disorders  Musculoskeletal Ultrasound

Ralph Budd, M.D. University Distinguished Professor of Medicine, Microbiology & Molecular Genetics Director, Immunobiology and Vermont Center for Immunology and Infectious Diseases  Systemic Lupus Erythematosus (SLE)  Inflammatory Arthritis ( T cells)  T cell homeostatic proliferation in autoimmune diseases  Metabolic regulation of cell death in the immune system

Chi Chi Lau, M.D. Associate Professor of Medicine  Systemic Lupus  Inflammatory arthritis  Connective tissue disorders

Scott Legunn, M.D. Assistant Professor of Medicine  Rheumatoid Arthritis  Polymyalgia Rheumatica/Giant Cell Arteritis  Psoriatic Arthritis  Vasculitis

Bonita Libman, M.D. Professor of Medicine Division Chief, Rheumatology and Clinical Immunology Program Director, Rheumatology Fellowship Training Program  Systemic Lupus Erythematosus  Rheumatoid Arthritis  Psoriatic Arthritis

Alana Nevares, M.D. Assistant Professor of Medicine  Giant Cell Arteritis  ANCA Associated Vasculitis  Autoimmune Eye Disease

Sanjeev Patil, M.D. Assistant Professor of Medicine

164

 Vasculitis  Rheumatoid Arthritis  Psoriatic Arthritis  Ankylosing Spondylitis  Inflammatory Muscle Disease  Musculoskeletal Sarcoidosis

Fellows

Matthew Jaenicke, M.D., graduated June 30, 2020

Jeanne Gosselin, M.D., 2nd year fellow

Brendan Thoms, M.D., Ph.D., 1st year fellow

Nurse Practitioners and Physician Assistants:

Morgan Merchand, APRN

Leadership in Professional Societies

Bonita Libman, M.D., member, American College of Rheumatology RheumPAC Committee

Narandra Bethina, M.D., member, American College of Rheumatology Musculoskeletal Ultrasound Plan- ning Committee

Narandra Bethina, M.D., member, USSONAR Fundamental Education Committee

Narandra Bethina, M.D., Educational Mentor, USSONAR (Ultrasound School of North American Rheu- matologists)

Alana Nevares, M.D., Award Selection Committee, Panamerican League of Associations for Rheumatol- ogy (PANLAR) Stimulus and Schumacker Awards

Alana Nevares, M.D., Reviewer, Abstract Selection Sub-Committee for Orthopedics, Low Back Pain and Rehabilitation, American College of Rheumatology 2019 National Meeting

Alana Nevares, M.D., Reviewer, Journal of Clinical Rheumatology

Editorship

Ralph Budd, M.D., Editor, Textbook of Rheumatology 11th edition, 2020

Study Section

165

Ralph Budd, M.D. T32 Grant Reviews AITC NIAID COBRE Phase I Grant Review NIGMS Arthritis Connective Tissue Sciences (ACTS) NIH Study Section T32 Grant Reviews AITC NIAID NIH Immunity and Host Defense

Grants

Chi Chi Lau, M.D. Rheumatology Research Foundation Medical Student Research Preceptorship Grant ($4000)

Alana Nevares, M.D. Rheumatology Research Foundation Medical Student Research Preceptorship Grant ($4000)

Ralph Budd, M.D. NIAID R21 AI151407 Ligands for Human Synovial Gamma/Delta T cells 2020-2022 NIAID T32 AI 055402 Immunology/Infectious Diseases Training Grant 2005-2021 NIGMS P30 GM118228 Vermont Immunobiology/Infections Diseases Center (COBRE Phase III Grant) 2016-2021

Publications

Peer Reviewed Publications

Collins C, Luui Y, Santos AM, Ballif BA, Gogerly-Moragoda AM, Brouwer H, Ross R, Balagurunathan K, Sharma S, Wright GJ, Davis S, Budd RC. Detection of Cell Surface Ligands for Human Synovial γδ T Cells. J Immunol 2019 Nov 1;203(9):2369-2376. PMID: 31548331

Fortner, KA, Blanco, LP, Buskiewicz, I, Huang, N, Gibson, PC, Cook, DL, Pederson, HL, Yuen, PST, Murphy, MP, Perl, A, Kaplan, MJ, and Budd, RC. Targeting Mitochondrial Oxidative Stress with MitoQ Reduces NET Formation and Kidney Disease in Lupus-Prone MRL-lpr Mice. Lupus Sci Med 2020 Apr;7(1):e000387. doi: 10.1136/lupus-2020-000387. Epub 2020 Apr 16.

Van Eeghen, C., Edwards, M., Libman, BS, MacLean, C.D., Kennedy, A.G. Order from Chaos: An Initiative to Improve Opioid Prescribing in Rheumatology Using Lean A3. ACR Open Rheumatol. 2019 Sep 4;1(9):546-551 doi: 10.1002/acr2.11078. eCollection 2019 Nov. PMID: 31777838 [PubMed] Free PMC Article

Kanner C, Libman B, Merchand M, Lemos D. Resolution of Osseous Sarcoidosis with Methotrexate, Case Rep Rheumatol. 2019 Nov 11;2019:4156313. doi: 10.1155/2019/4156313. eCollection 2019.PMID: 31886004

166

Nevares, A, Raut, R, Libman, B, Hajj-Ali R. Noninfectious Autoimmune Scleritis: Recognition, Systemic Associations, and Therapy. Curr Rheumatol Rep. 2020 Mar 26;22(4):11. doi: 10.1007/s11926-020-0885- y.PMID: 32219644

Aslam F, England BR, Cannella A, Sharp V, Kao L, Arnason J, Albayda J, Bakewell C, Sanghvi S, Fairchild R, Torralba K, Evangelisto A, DeMarco P, Bethina N, Kissin E. Ultrasound Doppler and tenosynovial fluid analysis in tenosynovitis. Annals of the Rheumatic Diseases 2020;79:908-913. PMID: 32213497 DOI: 10.1136/annrheumdis-2020-216927

Book Chapters and Non-Peer Reviewed Publications

Alana Nevares, M.D. Introduction to Autoimmune Rheumatic Disorders, online Merck Manual Profes- sional Version, February 2020

167 Department of Medicine FY2020 External UVM Research Applications Submitted By Division By PI

Requested Requested Requested Requested Requested Division PI Sponsor Project Title Start Date End date Direct Costs Indirect Costs Total

The Role of sSmall Nucleolar RNAs in Adult Cardiology Greetham, Lucy E American Heart Association - National 01/01/20 12/31/20 $ 31,016 $ - $ 31,016 Epicardial Cell Differentiation Myocardial Ischemia and Transfusion (MINT) - Cardiology Keating, Friederike Kyra Rutgers University 06/01/19 05/31/20 $ 1,923 $ 1,077 $ 3,000 CCC Nitric Oxide and Acute Kidney Injury (NO-AKI Phase 1): A Proof of Concept Study in Patients Cardiology Lahoud, Rony A. Sonogenix LLC 04/01/20 03/31/21 $ 38,042 $ 21,304 $ 59,346 Undergoing Transcatheter Aortic Valve Replacement Pilot Pace HFpEF – Physiologic Accelerated Pacing Cardiology Lustgarten, Daniel L Medtronic Inc as a Treatment in Patients with Heart Failure with 01/01/20 12/31/20 $ 126,843 $ 35,516 $ 162,359 Preserved Ejection Fraction Assessment of Individual Risk of Cardiovascular Cardiology Schneider, David John National Institutes of Health/NIH 12/01/20 11/30/21 $ 717,151 $ 159,025 $ 876,176 Events by Platelet Fc-Gamma-RIIa

Research Services Agreement: Monitoring of Cardiology Schneider, David John PLX Pharma Inc. Platelet Activation/Aggregation by Pharmaceutical 09/15/19 09/14/20 $ 250,000 $ 75,000 $ 325,000 Lipid Excipients (MAPLE Study)

Research Services Agreement: Monitoring of Cardiology Schneider, David John PLX Pharma Inc. Platelet Activation/Aggregation by Pharmaceutical 01/01/20 08/31/20 $ 70,000 $ 21,000 $ 91,000 Lipid Excipients (MAPLE Study) Cardiology Schneider, David John PLX Pharma Inc. MAPLE-2 06/15/20 12/31/20 $ 70,000 $ 21,000 $ 91,000 Cardiology Spees, Jeffrey L. Greenseal Cannabis Co. GreenSeal Research Services 05/15/20 05/14/21 $ 196,245 $ 72,333 $ 268,578 Control of Alternative Splicing During Cardiac Cardiology Spees, Jeffrey L. National Institutes of Health/NIH 12/01/20 11/30/21 $ 262,632 $ 130,375 $ 393,007 Remodeling by Snord116 lncRNA Cardiology Spees, Jeffrey L. WPP 3MP, LLC WPP-research Service Agreement 07/01/20 06/30/21 $ 143,019 $ 35,755 $ 178,774 Cardiology Toth, Michael John National Institutes of Health/NIH Translational rehabititation R61/R33 04/01/21 03/31/26 $ 1,431,446 $ 719,663 $ 2,151,109 Skeletal Muscle Atrophy and Dysfunction in Cardiology Toth, Michael John Natl Inst Arthritis Musculoskl/NIAMS/NIH 07/01/18 06/30/19 $ 330,345 $ 164,551 $ 494,896 Human Cancer Innovations Toward Connected Transitional Cardiology Toth, Michael John Natl Inst Arthritis Musculoskl/NIAMS/NIH 03/01/20 02/28/21 $ 150,000 $ 84,000 $ 234,000 Rehabilitation After Orthopedic Surgery Skeletal Muscle Atrophy and Dysfunction Cardiology Toth, Michael John Natl Inst on Aging/NIA/NIH 07/01/19 06/30/20 $ 357,357 $ 181,701 $ 539,058 Following Total Knee Arthroplasty Molecular Mechanisms of Adaptive Islet Beta Cell Endocrinology Gupta, Dhananjay Natl Inst Diabetes Digest Kidn/NIDDK/NIH 04/01/20 03/31/21 $ 405,564 $ 172,412 $ 577,976 Function, Growth and Survival Endocrinology Gupta, Dhananjay US Department of Defense/DOD DoD-SNORD116-Diabetes 12/01/20 11/30/22 $ 200,000 $ 112,000 $ 312,000 The Impact of Primary Care Payment Reform on GIM Atherly, Adam J Donaghue Foundation 12/01/19 11/30/20 $ 175,666 $ 17,567 $ 193,233 Population Health Outcomes The Impact of Global Budgets and Community GIM Atherly, Adam J Robert Wood Johnson Foundation Health Workers on Health, Health Equity and 04/01/20 03/31/21 $ 159,360 $ 19,123 $ 178,483 Cross-Sector Interconnectedness in Vermont

Apoyo Con Carino: Patient Navigation to Improve GIM Atherly, Adam J University of Colorado Denver 08/01/19 07/31/20 $ 32,921 $ 18,436 $ 51,357 Palliative Care for Seriously Ill Latinos

Page 1 of 6 Department of Medicine FY2020 External UVM Research Funding by Division by PI

Division PI Sponsor Project Title Start Date End Date Direct Indirect Total

Cardiology Correa De Sa, Daniel D CoreMap, Inc. CoreMap Mapping of Atrial Fibrillation 5/15/2019 5/31/2020 $3,341 $935 $4,276 Cardiology Correa De Sa, Daniel D CoreMap, Inc. CoreMap Mapping of Atrial Fibrillation 3/23/2018 6/14/2021 $7,853 $4,397 $12,250 Cardiology Keating, Friederike Kyra Rutgers University Myocardial Ischemia and Transfusion (MINT) - CCC 6/1/2019 5/31/2020 $1,923 $1,077 $3,000 Cardiology Keating, Friederike Kyra Rutgers University Myocardial Ischemia and Transfusion (MINT) CCC 6/1/2019 5/31/2020 $7,051 $3,949 $11,000 Cardiology Keating, Friederike Kyra Rutgers University Myocardial Ischemia and Transfusion (MINT) - CCC 6/1/2018 5/31/2019 $1,294 $706 $2,000 Nitric Oxide and Acute Kidney Injury (NO-AKI Phase 1): A Proof of Concept Study in Cardiology Lahoud, Rony A Sonogenix 4/1/2020 3/31/2021 $32,042 $17,944 $49,986 Patients Undergoing Transcatheter Aortic Valve Replacement Research Services Agreement: Monitoring of Platelet Activation/Aggregation by Cardiology Schneider, David John PLX Pharma Inc. 9/10/2019 9/8/2020 $250,000 $75,000 $325,000 Pharmaceutical Lipid Excipients (MAPLE Study) Monitoring of Platelet Activation/Aggregation by Pharmaceutical Lipid Excipients – 2 Cardiology Schneider, David John PLX Pharma Inc. 6/15/2020 12/31/2020 $70,000 $21,000 $91,000 (MAPLE-2) Natl Inst Arthritis Skeletal Muscle Atrophy and Dysfunction in Human Cancer Cardiology Toth, Michael John 5/1/2019 4/30/2020 $221,395 $105,991 $327,386 Musculoskl/NIAMS/NIH Natl Inst Arthritis Skeletal Muscle Atrophy and Dysfunction in Human Cancer Cardiology Toth, Michael John 5/1/2020 4/30/2021 $323,531 $153,140 $476,671 Musculoskl/NIAMS/NIH Cardiology Toth, Michael John Natl Inst on Aging/NIA/NIH Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty 6/1/2019 5/31/2020 $290,312 $147,471 $437,783 University of Massachusetts Sex-specific adaptation to different resistance exercise programs in older adults Cardiology Toth, Michael John 4/1/2020 3/31/2021 $20,291 $11,363 $31,654 Amherst Veterans Medical Research AC6 in Clinical Heart Failure Cardiology Watkins, Matthew Wells 4/1/2012 12/31/2017 $6,717 $1,894 $8,611 Foundation Cardiology Total $1,235,750 $544,867 $1,780,617 Retrospective Analysis of the Management and Outcomes of Patients with Cutaneous Northern N. E. Clinical Oncology Dermatology Bui, Melanie R Squamous Cell Carcinoma of the Upper Extremity Treated at the University of Vermont 5/15/2019 5/15/2020 $2,000 $0 $2,000 Society Medical Center Dermatology Total $2,000 $0 $2,000 Endocrinology Kien, Craig L Yale University Mechanisms of Obesity and Its Metabolic Complications in Youth 5/1/2020 4/30/2021 $12,884 $7,215 $20,099 Endocrinology Total $12,884 $7,215 $20,099 Harnessing the Electronic Health Record in Primary Care for Hepatocellular Carcinoma Gastroenterology Lidofsky, Steven D. Maine Medical Center 10/1/2019 6/30/2020 $22,870 $12,715 $35,585 Surveillance in Cirrhosis Gastroenterology Jensen, Gordon L Geisinger Clinic Rural Aging Study 8/1/2019 7/31/2020 $18,172 $1,817 $19,989 GI Total $41,042 $14,532 $55,574 Substance Abuse Mental Increasing the Pipleline of MAT Prescribers: DATA Waiver Training for All Vermont General Int Medicine Sobel, Halle G 9/30/2019 9/29/2020 $94,032 $7,523 $101,555 Health/SAMHSA Medical Students at The Larner College of Medicine Apoyo Con Carino: Patient Navigation to Improve Palliative Care for Seriously Ill Latinos General Int Medicine Atherly, Adam J University of Colorado Denver 8/1/2019 7/31/2020 $32,921 $18,436 $51,357 Robert Wood Johnson The Impact of Global Budgets and Community Health Workers on Health, Health Equity General Int Medicine Atherly, Adam J 5/1/2020 4/30/2023 $446,362 $53,563 $499,925 Foundation and Cross-Sector Interconnectedness in Vermont GIM Total $573,315 $79,522 $652,837 American Heart Association - 2019 Student Scholarships in Cerebrovascular Disease and Stroke: Charles Nicoli Hem/Onc Cushman, Mary 7/1/2019 5/30/2020 $2,000 $0 $2,000 National Use of HDL Proteome in the Prediction of Cog Impair and Alzheimer's Disease Hem/Onc Cushman, Mary Mount Sinai School of Medicine 3/1/2019 12/31/2019 $17,253 $8,695 $25,948

University of Alabama at VCID and Stroke in a Bi-Racial National Cohort Hem/Onc Cushman, Mary 2/1/2019 1/31/2020 $477,530 $267,417 $744,947 Birmingham University of Alabama at VCID and Stroke in a Bi-Racial National Cohort Hem/Onc Cushman, Mary 2/1/2020 1/31/2021 $605,647 $339,162 $944,809 Birmingham Hem/Onc Cushman, Mary University of Minnesota Epidemiology of Venous Thrombosis and Pulmonary Embolism 4/1/2019 3/31/2020 $25,704 $14,394 $40,098

Hem/Onc Cushman, Mary University of North Carolina The National Longitudinal Study of Adolescent Health 5/1/2020 4/30/2021 $0 $0 $0

Hem/Onc Cushman, Mary University of North Carolina The National Longitudinal Study of Adolescent Health 5/1/2020 4/30/2021 $251,145 $140,641 $391,786

Hem/Onc Cushman, Mary University of North Carolina The Add Health Epigenome Resource: Life Course Stressors and Epigenomic 4/1/2020 3/31/2021 $47,844 $26,793 $74,637 Modifications in Adulthood Hem/Onc Cushman, Mary Johns Hopkins University Transitions to Family Caregiving and the Impact on Health Indicators 6/1/2019 5/31/2020 $60,727 $34,007 $94,734

Hem/Onc Cushman, Mary Johns Hopkins University Transitions to Family Caregiving and the Impact on Health Indicators 6/1/2020 3/31/2020 $28,846 $16,154 $45,000 Vermont AHS Department of CoC Survivorship Grant Hem/Onc Dittus, Kim L. 9/1/2019 6/30/2020 $54,687 $15,313 $70,000 Health AFT-28 CANVAS Direct Oral Anticoagulants DOACs versus LMWH Warfarin for VTE in Hem/Onc Holmes, Chris Elaine Alliance Foundation Trials, LLC 9/8/2017 9/7/2021 $5,250 $0 $5,250 Cancer A Randomized Effectiveness Trial CANVAS Trial

Page 1 of 3 Department of Medicine FY2020 External UVM Research Funding by Division by PI

Division PI Sponsor Project Title Start Date End Date Direct Indirect Total

AFT-38: A Phase III, Randomized, Open Label Trial to Evaluate the Efficiency and Safety of Palbociclib + AntiHER2 Therapy + Endocrine Therapy vs. Anti-HER2 Therapy + Hem/Onc Kaufman, Peter A Alliance Foundation Trials, LLC 6/17/2019 6/15/2024 $18,400 $7,890 $26,290 Endocrine Therapy after Induction Treatment for Hormone Reception Positive (HR+)/HER2 Pos AFT-38:A Phase III Randomized, Open Label Trial to Evaluate the Efficiency and Safety of Hem/Onc Kaufman, Peter A Alliance Foundation Trials, LLC Palbociclib + AntiHER2 Therapy+Endocrine Therapy vs Anti-HER2 Therapy +Endocrine 6/17/2019 6/15/2024 $6,510 $2,790 $9,300 Therapy after Induction Treatm BC181146: Congressionally Directed Medical Research Programs Breast Cancer Research Program Breakthrough Award Levels 3 and 4 Prospectively Randomized, Hem/Onc Wood, Marie E. Dana Farber Cancer Institute 9/15/2019 9/14/2020 $19,433 $10,882 $30,315 Placebo-Controlled Phase III Study to Determine the Effect of Denosumab on Breast Cancer Prevention in Hem/Onc Wood, Marie E. Mayo Clinic Alliance Cancer Control Program - Prevention Committee Co-Chair Salary Support 8/14/2019 7/31/2020 $23,207 $12,996 $36,203 Natl Heart Lung and Blood Thrombosis and Bleeding Risk Assessment in Medical Inpatients Hem/Onc Zakai, Neil A. 3/1/2020 2/28/2021 $512,868 $167,611 $680,479 Inst/NHLBI/NIH Oregon Health Sciences Identification of the Role of HDL Function in Human Cardiovascular Disease through Hem/Onc Zakai, Neil A. 1/1/2020 12/31/2020 $24,160 $13,529 $37,689 University Proteomics and Genetics Hem/Onc Zakai, Neil A. University of Minnesota Contemporary Venous Thromboembolism Treatment 12/1/2019 11/30/2020 $50,562 $28,315 $78,877 Hem/Onc Total $2,231,773 $1,106,589 $3,338,362 Immunobiology Botten, Jason W. Celdara Medical, LLC A Novel Antibody Therapy for Sin Nombre Virus Infection 1/1/2019 12/31/2019 $63,462 $35,539 $99,001 Immunobiology Botten, Jason W. Celdara Medical, LLC A novel antibody therapy for Sin Nombre virus infection 1/1/2020 12/31/2020 $63,462 $35,538 $99,000 Screening of novel anti-SARS-CoV-2 peptides for infection of Vero E6 cells with SARS- Immunobiology Botten, Jason W. Jet Propulsion Laboratory 6/1/2020 12/30/2020 $64,104 $35,898 $100,002 CoV-2 Deep Sequencing the Lymphocytic Choriomeningitis Arenavirus Quasispecies to Identify Natl Inst Allergy Immunobiology Botten, Jason W. and Functionally Validate the Molecular Signature of Defective Interfering Particles 6/1/2020 5/31/2021 $173,439 $75,370 $248,809 Infectious/NIAID/NIH

Immunobiology Budd, Ralph C Mitotherapeutix, LLC MCJ as a Target for Liver Diseases 7/1/2018 9/30/2019 $11,342 $0 $11,342 Immunobiology Budd, Ralph C Mitotherapeutix, LLC MCJ as a Target for Liver Diseases 7/1/2018 11/30/2019 $2,996 $0 $2,996 Natl Inst Allergy Vermont Immunology / Infectious Diseases Training Grant Immunobiology Budd, Ralph C 9/1/2019 8/31/2020 $91,231 $0 $91,231 Infectious/NIAID/NIH Natl Inst Allergy Ligands for Human Synovial Gamma/Delta T Cells Immunobiology Budd, Ralph C 4/9/2020 3/31/2021 $154,970 $77,216 $232,186 Infectious/NIAID/NIH Natl Inst Gen Medical Vermont Immunology/Infectious Diseases Center Immunobiology Budd, Ralph C 8/1/2019 7/31/2020 $752,329 $413,655 $1,165,984 Sciences/NIGMS/NIH Immunobiology Rincon, Mercedes ME Research UK Exploring an Anti-Citrullinated Antibody Signature in ME/CFS 4/1/2019 8/31/2019 $18,535 $0 $18,535 Natl Inst Allergy GSK3B in TCR Repertoire and Immune Diseases Immunobiology Rincon, Mercedes 8/1/2019 7/31/2020 $259,400 $129,374 $388,774 Infectious/NIAID/NIH Immunobiology Total $1,655,270 $802,589 $2,457,859 Drug Injection Surveillance and Care Enhancement for Rural Northern New England Infectious Disease Dejace, Jean Baystate Medical Center 8/1/2019 7/31/2020 $36,451 $20,413 $56,864 (DISCERNNE) Natl Inst Allergy Repurposing the EMD-Serono "Mini-Library" for Cryptosporidium Drug Development Infectious Disease Huston, Christopher Dwight 2/1/2020 1/31/2021 $179,124 $51,128 $230,252 Infectious/NIAID/NIH Natl Inst Allergy Preclinical Optimization of a Parasiticidal Drug for Cryptosporidiosis Infectious Disease Huston, Christopher Dwight 3/1/2020 2/28/2021 $509,293 $110,978 $620,271 Infectious/NIAID/NIH ID Total $724,868 $182,519 $907,387 A Randomized Clinical Trial of a Communication Tool to Improve Access to Palliative Care Nephrology Cheung, Katharine L University of Wisconsin 6/15/2019 5/31/2020 $23,500 $13,160 $36,660 for Patients with End-stage Renal Disease IMPROVE AKI: A Cluster-Randomized Trial of Team-Based Coaching Interventions to Nephrology Solomon, Richard J. Dartmouth College 6/1/2019 5/31/2020 $20,703 $11,594 $32,297 IMPROVE Acute Kidney Injury Nephrology- Total $44,203 $24,754 $68,957 Pulmonary Bates, Jason H. Boston University A Multi-Scale Computational Model of the Extracellular Matrix of the Lung 6/1/2019 5/31/2020 $188,027 $98,410 $286,437 Natl Heart Lung and Blood Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung Injury Pulmonary Bates, Jason H. 7/1/2019 6/30/2020 $544,619 $88,420 $633,039 Inst/NHLBI/NIH Natl Heart Lung and Blood Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung Injury Pulmonary Bates, Jason H. 7/1/2020 6/30/2021 $543,808 $89,230 $633,038 Inst/NHLBI/NIH Natl Heart Lung and Blood Pilot of Lifestyle in Asthma INtervention (PLAN) Pulmonary Dixon, Anne Elizabeth 5/1/2019 4/30/2020 $182,084 $52,462 $234,546 Inst/NHLBI/NIH Natl Heart Lung and Blood Mitochondrial Redox Perturbations in Obese Allergic Asthma Pulmonary Dixon, Anne Elizabeth 8/1/2019 7/31/2020 $449,281 $189,746 $639,027 Inst/NHLBI/NIH Pulmonary Dixon, Anne Elizabeth University of Illinois RofLumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE) 6/1/2019 5/31/2023 $55,640 $22,256 $77,896 Pulmonary Irvin, Charles G Celdara Medical, LLC DRIVEN: Accelerating Medical Entrepreneurship in the Northeast 9/1/2019 8/31/2020 $116,667 $23,333 $140,000

Page 2 of 3 Department of Medicine FY2020 External UVM Research Funding by Division by PI

Division PI Sponsor Project Title Start Date End Date Direct Indirect Total

Natl Inst Gen Medical Fostering entrepreneurship in biomedical research Pulmonary Irvin, Charles G 3/1/2020 2/28/2021 $309,243 $24,739 $333,982 Sciences/NIGMS/NIH Natl Inst Gen Medical Fostering entrepreneurship in biomedical research Pulmonary Irvin, Charles G 3/1/2020 2/28/2021 $132,000 $0 $132,000 Sciences/NIGMS/NIH Pulmonary Irvin, Charles G American Lung Association Airways Clinical Research Center (ACRC) Core Award 7/1/2019 6/30/2020 $100,000 $0 $100,000 Pulmonary Irvin, Charles G American Lung Association Lung Health Cohort study 5/1/2020 4/30/2021 $18,700 $0 $18,700 Pulmonary Irvin, Charles G American Lung Association Losartan Effects on Emphysema Progress Trial (LEEP) 4/16/2020 6/30/2021 $3,000 $0 $3,000 University of Alabama at Beta Blockers for the Prevention of Acute Exacerbations of COPD Pulmonary Kaminsky, David A 10/1/2019 9/30/2020 $32,428 $9,080 $41,508 Birmingham Natl Heart Lung and Blood CT Characteristics of Emphysema for Evaluation of Pulmonary Nodules Pulmonary Kinsey, C. Matthew 8/1/2019 7/31/2020 $157,554 $12,604 $170,158 Inst/NHLBI/NIH Damon Runyon Cancer Research EBUS-TBNI of Cisplatin Optimization in Heterogeneous Lung Tumors Pulmonary Mori, Vitar 4/1/2020 3/31/2021 $78,000 $0 $78,000 Foundation Natl Heart Lung and Blood Obese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial Function Pulmonary Poynter, Matthew Edward 8/1/2019 7/31/2020 $497,231 $278,449 $775,680 Inst/NHLBI/NIH Natl Heart Lung and Blood Ketone Body Supplementation in Obese Asthma Pulmonary Poynter, Matthew Edward 4/1/2020 3/31/2021 $287,980 $157,651 $445,631 Inst/NHLBI/NIH Natl Heart Lung and Blood Multidisciplinary Training in Lung Biology Pulmonary Poynter, Matthew Edward 5/1/2020 4/30/2021 $324,202 $25,936 $350,138 Inst/NHLBI/NIH A Randomized Controlled Trial of a Combined Nutrition (Protein Supplementation) and Pulmonary Stapleton, Renee D. Baxter Healthcare Corporation EXercISe Intervention in Mechanically Ventilated Critically Ill Patients the NEXIS Trial 8/21/2019 2/28/2021 $16,667 $3,333 $20,000

Therapeutic Modulation of Zinc for Lung Injury and Mechanobiology Pulmonary Stapleton, Renee D. Brigham and Women's Hospital 4/1/2020 3/31/2021 $64,806 $36,290 $101,096 Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation Pulmonary Stapleton, Renee D. Healthy Design Ltd. Co. 4/1/2018 6/30/2020 $359,132 $95,657 $454,789 and Cognitive Impairment Natl Heart Lung and Blood Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trial of Pulmonary Stapleton, Renee D. 4/1/2020 3/31/2021 $561,703 $148,130 $709,833 Inst/NHLBI/NIH Combined Cycle Ergometry and Amino Acids in the ICU Improving Palliative Care for Older Seriously Ill Hospitalized Patients and Their Families: A Pulmonary Stapleton, Renee D. Natl Inst on Aging/NIA/NIH Randomized Trial of an Informed Assent Communication Intervention about CPR 3/1/2020 2/28/2021 $457,422 $68,967 $526,389

Natl Heart Lung and Blood Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness Pulmonary Suratt, Benjamin T 7/1/2019 6/30/2020 $621,284 $157,323 $778,607 Inst/NHLBI/NIH (NEXIS-FLAME) Cystic Fibrosis Fdtn Cystic Fibrosis Foundation Research Support Pulmonary Teneback, Charlotte C 12/1/2019 3/31/2020 $5,996 $480 $6,476 Therapeutics, Inc Cystic Fibrosis Fdtn Therapeutics Development Center Pulmonary Teneback, Charlotte C 1/1/2020 3/31/2020 $22,846 $1,828 $24,674 Therapeutics, Inc Cystic Fibrosis Fdtn Therapeutics Development Center Pulmonary Teneback, Charlotte C 4/1/2020 3/31/2021 $115,660 $9,252 $124,912 Therapeutics, Inc Pulmonary Teneback, Charlotte C Seattle Children's Hospital Standardized Treatment of Pulmonary Exacerbations II (STOP 2) 1/1/2016 12/31/2999 $1,928 $154 $2,082

Pulmonary Weintraub, Zachary Cystic Fibrosis Foundation Program for Adult Care Excellence (PACE) 10/1/2019 9/30/2020 $37,025 $2,962 $39,987

Pulmonary Weiss, Daniel J Alpha-1 Foundation 2019 Stem Cells and Cell Therapies in Lung Biology and Disease 7/15/2019 7/18/2019 $5,000 $0 $5,000

Pulmonary Weiss, Daniel J Cystic Fibrosis Foundation Role of Glycoproteins in Lung Recellularization 4/1/2020 3/31/2021 $125,000 $0 $125,000 Natl Heart Lung and Blood Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases Pulmonary Weiss, Daniel J 7/4/2019 6/30/2020 $30,001 $0 $30,001 Inst/NHLBI/NIH Pulmonary Weiss, Daniel J Office of the Director/NIH Zeta View TWIN Laser Nanoparticle Tracking Analyzer 8/1/2019 7/31/2020 $122,058 $0 $122,058 Stem Cells, Therapies, and Bioengineering in Lung Biology Conference Pulmonary Weiss, Daniel J United Therapeutics Corporation 7/1/2019 9/30/2019 $3,623 $1,377 $5,000 Pulmonary- Total $6,570,615 $1,598,070 $8,168,685

Grand Total $13,091,720 $4,360,657 $17,452,377

Page 3 of 3 Department of Medicine FY2020 External UVM Research Applications Submitted By Division By PI

Requested Requested Requested Requested Requested Division PI Sponsor Project Title Start Date End date Direct Costs Indirect Costs Total

Agency Healthcare Research GIM Atherly, Adam J AHRQ-Atherly-COVID-R01 09/30/20 09/29/22 $ 640,895 $ 358,901 $ 999,796 Quality/AHRQ Specifications for Set of Analysis-Ready Health GIM Atherly, Adam J Vermont Green Mountain Care Board 09/03/19 09/02/20 $ 158,686 $ 88,864 $ 247,550 Care Data Products GIM Duchene, Brittany Chest Foundation Duchene CHEST 09/15/20 09/14/21 $ 29,859 $ - $ 29,859 GIM Gleason, Kelsey Dartmouth College Dartmouth Subaward-Gleason 07/01/20 06/30/22 $ 111,215 $ 62,281 $ 173,496 Magnesium and Inflammatory Markers in Chronic GIM Littenberg, Benjamin National Institutes of Health/NIH 08/01/20 07/31/21 $ 227,469 $ 127,383 $ 354,852 Pain GIM Littenberg, Benjamin National Institutes of Health/NIH HEAL/PRISM Grant 09/01/20 08/31/25 $ 4,499,143 $ 2,519,518 $ 7,018,661 GIM Littenberg, Benjamin PCORI Patient Cntrd Outcomes Res Inst PCORI COVID Enhancement 07/01/20 06/30/21 $ 356,627 $ 142,651 $ 499,278

GIM Plante, Timothy B. American Heart Association - Founders Risk Factors for Hypertension 04/01/20 03/31/21 $ 70,000 $ 7,000 $ 77,000 Agency Healthcare Research GIM Van Eeghen, Constance O. AHRQ-R18-Van Eeghen 04/01/21 03/31/25 $ 1,018,397 $ 570,302 $ 1,588,699 Quality/AHRQ GIM Van Eeghen, Constance O. Arizona State University PCORI-Subaward 08/01/20 07/31/22 $ 49,015 $ 19,606 $ 68,621 LOI for the PCORI Eugene Washington GIM Van Eeghen, Constance O. PCORI Patient Cntrd Outcomes Res Inst 08/01/20 07/31/21 $ 70,837 $ 28,335 $ 99,172 Engagement Award Integrating Behavioral Health in Primary Care (IBH- GIM Van Eeghen, Constance O. PCORI Patient Cntrd Outcomes Res Inst 09/01/20 08/31/21 $ 71,311 $ 28,524 $ 99,835 PC) Hem/Onc Adrianzen Herrera, Diego AAMDS-LOI 01/01/21 12/31/22 $ 54,546 $ 5,454 $ 60,000 Vitamin K Status in Relation to Incidence of Stroke Hem/Onc Cushman, Mary Columbia University 07/01/20 06/30/21 $ 30,686 $ 17,184 $ 47,870 and Trajectory of Cognitive Decline Biological Embodiment of Risk and Racial Hem/Onc Cushman, Mary Duke University 07/01/20 06/30/21 $ 25,785 $ 14,440 $ 40,225 Disparities in Breast Cancer Hem/Onc Cushman, Mary National Institutes of Health/NIH LOI: RAPID COVID 06/01/20 05/31/22 $ 4,371,590 $ 432,169 $ 4,803,759 Vermont Center for Cardiovascular and Brain Natl Inst Gen Medical Hem/Onc Cushman, Mary Health: Centers of Biomedical Research Excellence 12/01/20 11/30/21 $ 1,799,999 $ 799,333 $ 2,599,332 Sciences/NIGMS/NIH (COBRE) (P20) -Resubmission Hem/Onc Cushman, Mary St. Michael's Hospital Toronto RAPID-COVID-DoD 10/01/20 09/30/23 $ 952,759 $ 525,761 $ 1,478,520 Hem/Onc Cushman, Mary University of Alabama at Birmingham VCID and Stroke in a Bi-Racial National Cohort 04/01/18 03/31/19 $ 477,530 $ 267,416 $ 744,946 Vascular-brain Injury Progression after Stroke Hem/Onc Cushman, Mary University of California, San Francisco 07/01/20 06/30/21 $ 41,939 $ 23,486 $ 65,425 Study (VIPS) Hem/Onc Cushman, Mary University of California, San Francisco Ovbiagele REGARDS 04/01/21 03/31/26 $ 117,986 $ 66,073 $ 184,059 Epidemiology of Venous Thrombosis and Hem/Onc Cushman, Mary University of Minnesota 04/01/19 03/31/20 $ 25,704 $ 14,395 $ 40,099 Pulmonary Embolism Epidemiology of Venous Thrombosis and Hem/Onc Cushman, Mary University of Minnesota 12/01/20 11/30/21 $ 25,719 $ 14,403 $ 40,122 Pulmonary Embolism Hem/Onc Cushman, Mary University of North Carolina Add Health VI Core 11/01/20 10/31/25 $ 1,469,900 $ 791,760 $ 2,261,660 Hem/Onc Cushman, Mary University of North Carolina Add Health VI ADRD 11/01/20 10/31/25 $ 397,357 $ 222,521 $ 619,878 Transitions to Family Caregiving and the Impact Hem/Onc Cushman, Mary Johns Hopkins University 04/01/19 03/31/20 $ 60,727 $ 34,007 $ 94,734 on Health Indicators Modified LDL in Circulating Immune Complexes, Hem/Onc Cushman, Mary Medical University of South Carolina 07/01/20 06/30/21 $ 31,046 $ 17,386 $ 48,432 Incident Stroke and CHD Events Hem/Onc Greenblatt, Marc National Institutes of Health/NIH Genomic Expert Panels (U24) 04/01/21 03/31/24 $ 722,155 $ 299,656 $ 1,021,811 Page 2 of 6 Department of Medicine FY2020 External UVM Research Applications Submitted By Division By PI

Requested Requested Requested Requested Requested Division PI Sponsor Project Title Start Date End date Direct Costs Indirect Costs Total

Improving VTE Prevention in the Ambulatory Hem/Onc Holmes, Chris Elaine Maine Medical Center 07/01/20 06/30/21 $ 50,000 $ 27,800 $ 77,800 Cancer Clinic (VTEPACC) Hem/Onc Jasra, Sakshi Northern N. E. Clinical Oncology Society NNECOS-Jasra 08/01/20 07/31/21 $ 11,360 $ - $ 11,360 Rural Urban BarrieRs in Cancer Screening Hem/Onc Wood, Marie E. Maine Medical Center 07/01/20 06/30/21 $ 49,980 $ 27,789 $ 77,769 (RUBRICS) The Role of Sickle Hemoglobin Concentration in Hem/Onc Zakai, Neil A Johns Hopkins University 04/01/21 03/31/22 $ 71,812 $ 40,215 $ 112,027 Sickle Cell Trait-Related Nephropathy Hem/Onc Zakai, Neil A National Institutes of Health/NIH MITH COVID-19 07/01/20 06/30/21 $ 622,547 $ 207,668 $ 830,215 Metabolic Effects and Mechanisms for Heart Hem/Onc Zakai, Neil A University of California, San Francisco 07/01/20 06/30/21 $ 47,395 $ 18,981 $ 66,376 Failure in South Asians Hem/Onc Zakai, Neil A University of California, San Francisco Masala Expansion 04/01/21 03/31/26 $ 169,633 $ 87,235 $ 256,868

Hem/Onc Zakai, Neil A University of California, San Francisco Kanaya Masala 04/01/21 03/31/26 $ 267,840 $ 142,431 $ 410,271 Pulmonary Hypertension: Epidemiology, Hem/Onc Zakai, Neil A University of Minnesota 09/01/20 08/31/21 $ 72,324 $ 40,501 $ 112,825 Interventions and Outcomes Hem/Onc VCC Adrianzen Herrera, Diego Gabrielle's Angel Fdtn Cancer Research Clonal Hematopoiesis Biobanking 04/01/21 03/31/24 $ 204,545 $ 20,455 $ 225,000 Hem/Onc VCC Dittus, Kim L. Vermont AHS Department of Health CoC Survivorship Grant 09/01/19 06/30/20 $ 54,687 $ 15,313 $ 70,000 Hem/Onc VCC Dittus, Kim L. Vermont AHS Department of Health VDH Survivorship II 07/01/20 06/30/21 $ 49,270 $ 13,796 $ 63,066 AFT-38: A Phase III, Randomized, Open Label Trial to Evaluate the Efficiency and Safety of Palbociclib + AntiHER2 Therapy + Endocrine Therapy vs. Anti- Hem/Onc VCC Kaufman, Peter A Alliance Foundation Trials, LLC 07/01/19 06/30/20 $ 26,838 $ 11,502 $ 38,340 HER2 Therapy + Endocrine Therapy after Induction Treatment for Hormone Reception Positive (HR+)/HER2 Pos PrE0905: Randomized Trial of Gilteritinib vs Hem/Onc VCC Umyarova, Elvira PrECOG, LLC Midostaurin in FLT3 Mutated Acute Myeloid 02/01/20 12/31/99 $ 22,539 $ 6,762 $ 29,301 Leukemia (AML) BC181146: Congressionally Directed Medical Research Programs Breast Cancer Research Program Breakthrough Award Levels 3 and 4 Hem/Onc VCC Wood, Marie E. Dana Farber Cancer Institute 10/01/19 09/30/20 $ 19,433 $ 10,882 $ 30,315 Prospectively Randomized, Placebo-Controlled Phase III Study to Determine the Effect of Denosumab on Breast Cancer Prevention in

Alliance Cancer Control Program - Prevention Hem/Onc VCC Wood, Marie E. Mayo Clinic 08/01/19 07/31/20 $ 22,908 $ 12,829 $ 35,737 Committee Co-Chair Salary Support Hem/Onc VCC Wood, Marie E. Mayo Clinic Mayo/Alliance CoChair Prevention Salary 08/01/20 07/31/25 $ 119,760 $ 67,065 $ 186,825 Examination of Attitudes, Beliefs and Practices Hem/Onc VCC Wood, Marie E. Northern N. E. Clinical Oncology Society Regarding Point-of-Care Genetic Testing Among 08/15/19 08/14/20 $ 20,000 $ - $ 20,000 Northern New England medical Oncologists Immunobiology Botten, Jason W. Celdara Medical, LLC Botten ABATE STTR 4-2020 09/01/20 08/31/22 $ 168,892 $ 94,580 $ 263,472 Immunobiology Botten, Jason W. Celdara Medical, LLC Botten DRIVEN supplement 09/01/20 08/31/21 $ 191,224 $ 107,085 $ 298,309

Page 3 of 6 Department of Medicine FY2020 External UVM Research Applications Submitted By Division By PI

Requested Requested Requested Requested Requested Division PI Sponsor Project Title Start Date End date Direct Costs Indirect Costs Total

Immunobiology Botten, Jason W. Jet Propulsion Laboratory Botten Jet Propulsion Lab sub 06/01/20 05/31/21 $ 64,104 $ 35,898 $ 100,002 Deep Sequencing the Lymphocytic Choriomeningitis Arenavirus Quasispecies to Identify and Functionally Validate the Molecular Immunobiology Botten, Jason W. Natl Inst Allergy Infectious/NIAID/NIH 07/01/20 06/30/21 $ 173,439 $ 75,370 $ 248,809 Signature of Defective Interfering Particles

Immunobiology Budd, Ralph C Mitotherapeutix, LLC MCJ as a Target for Liver Diseases 07/01/19 08/31/19 $ 11,342 $ - $ 11,342 Immunobiology Budd, Ralph C National Institutes of Health/NIH Ligands for Human Synovial Gamma/Delta T Cells 07/01/20 06/30/21 $ 155,432 $ 65,288 $ 220,720

Immunobiology Budd, Ralph C National Institutes of Health/NIH Treatment of Mitochondrial Dysfunction in Lupus 07/01/20 06/30/21 $ 175,282 $ 75,165 $ 250,447 Vermont Immunology / Infectious Diseases Immunobiology Budd, Ralph C Natl Inst Allergy Infectious/NIAID/NIH 09/01/19 08/31/20 $ 247,454 $ 8,998 $ 256,452 Training Grant Natl Inst Gen Medical Immunobiology Budd, Ralph C Vermont Immunology/Infectious Diseases Center 07/01/20 06/30/21 $ 250,000 $ 140,000 $ 390,000 Sciences/NIGMS/NIH Natl Inst Gen Medical Immunobiology Budd, Ralph C Budd COBRE Women's Health suppl 08/01/20 07/31/21 $ 200,000 $ 112,000 $ 312,000 Sciences/NIGMS/NIH DRIVEN: Accelerating Medical Entrepreneurship in Immunobiology Irvin, Charles G Celdara Medical, LLC 09/01/19 08/31/20 $ 115,931 $ 23,186 $ 139,117 the Northeast Immunobiology Rincon, Mercedes Natl Inst Allergy Infectious/NIAID/NIH GSK3B in TCR Repertoire and Immune Diseases 07/01/19 06/30/20 $ 268,375 $ 120,400 $ 388,775 Immunobiology Teuscher, Cory National Institutes of Health/NIH Teuscher R01 June 2020 04/01/21 03/31/26 $ 1,250,000 $ 700,000 $ 1,950,000 Drug Injection Surveillance and Care Enhancement Infectious Disease Dejace, Jean Baystate Medical Center 08/01/19 07/31/20 $ 36,451 $ 20,413 $ 56,864 for Rural Northern New England (DISCERNNE) Repurposing the EMD-Serono "Mini-Library" for Infectious Disease Huston, Christopher Dwight Natl Inst Allergy Infectious/NIAID/NIH 12/01/19 11/30/20 $ 188,273 $ 42,250 $ 230,523 Cryptosporidium Drug Development Preclinical Optimization of a Parasiticidal Drug for Infectious Disease Huston, Christopher Dwight Natl Inst Allergy Infectious/NIAID/NIH 04/01/20 03/31/21 $ 519,047 $ 102,440 $ 621,489 Cryptosporidiosis Trajectories and Vascular Mechanisms of Nephrology Cheung, Katharine L Doris Duke Charitable Foundation 07/01/20 06/30/21 $ 150,000 $ 15,000 $ 165,000 Cognitive Impairment in Chronic Kidney Disease APOL1 Long-term Kidney Transplantation Nephrology Prikis, Marios C. Joslin Diabetes Center, Inc., Outcomes Network Protocol Summary for Non- 08/01/19 05/31/20 $ 962 $ - $ 962 engaged Sites (APOLLO) IMPROVE AKI: A Cluster-Randomized Trial of Nephrology Solomon, Richard J. Dartmouth College Team-Based Coaching Interventions to IMPROVE 09/01/18 08/31/19 $ 22,908 $ 12,828 $ 35,736 Acute Kidney Injury The Relationship of Sex Hormones and Genomics Pulmonary Badlam, Jessica B Bayer Corporation in a Contemporary Population of Patients with 01/01/20 12/31/20 $ 59,999 $ 15,000 $ 74,999 PAH A Multi-Scale Computational Model of the Pulmonary Bates, Jason H. Boston University 09/01/18 08/31/19 $ 195,873 $ 109,689 $ 305,562 Extracellular Matrix of the Lung Preserving Epithelial Barrier Integrity in Ventilator- Pulmonary Bates, Jason H. Natl Heart Lung and Blood Inst/NHLBI/NIH 07/01/19 06/30/20 $ 557,313 $ 120,268 $ 677,581 Induced Lung Injury

Page 4 of 6 Department of Medicine FY2020 External UVM Research Applications Submitted By Division By PI

Requested Requested Requested Requested Requested Division PI Sponsor Project Title Start Date End date Direct Costs Indirect Costs Total

Preserving Epithelial Barrier Integrity in Ventilator- Pulmonary Bates, Jason H. Natl Heart Lung and Blood Inst/NHLBI/NIH 04/01/20 03/31/21 $ 445,906 $ 121,089 $ 566,996 Induced Lung Injury Pulmonary Dixon, Anne Elizabeth American Lung Association Dixon ALA COVID 07/01/20 06/30/22 $ 200,000 $ - $ 200,000 Obesity, Diet and Metabolic Dysfunction in the Pulmonary Dixon, Anne Elizabeth National Institutes of Health/NIH 07/01/20 06/30/21 $ 620,674 $ 114,770 $ 735,444 Genesis of Lung Disease Mitochondrial Redox Perturbations in Obese Pulmonary Dixon, Anne Elizabeth Natl Heart Lung and Blood Inst/NHLBI/NIH 04/01/18 03/31/19 $ 514,999 $ 224,861 $ 739,860 Allergic Asthma Pulmonary Dixon, Anne Elizabeth Natl Heart Lung and Blood Inst/NHLBI/NIH Dixon/Anathy 31339 COVID supplement 07/01/20 06/30/21 $ 251,440 $ 137,446 $ 388,886 The ALOHA Trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Adults with Pulmonary Dixon, Anne Elizabeth University of Illinois 12/01/20 11/30/21 $ 53,706 $ 28,143 $ 81,849 Uncontrolled Asthma Following the DASH Dietary Pattern Pulmonary Hoffman, Evan National Institutes of Health/NIH Hoffman F31 09/01/20 08/31/23 $ 133,760 $ - $ 133,760 Airways Clinical Research Center (ACRC) Core Pulmonary Irvin, Charles G American Lung Association 07/01/19 06/30/20 $ 100,001 $ - $ 100,001 Award Airways Clinical Research Center (ACRC) Core Pulmonary Irvin, Charles G American Lung Association 07/01/18 06/30/19 $ 33,333 $ - $ 33,333 Award Pulmonary Irvin, Charles G American Lung Association 30869 suppl - Funding for consortium 07/01/19 06/30/20 $ 30,000 $ - $ 30,000 Pulmonary Irvin, Charles G American Lung Association 30869 ALA ACRC Lung Health Cohort study 05/01/20 04/30/21 $ 18,700 $ - $ 18,700 Pulmonary Irvin, Charles G American Lung Association 30869 supplement - $11,111 discretionary 01/01/20 12/31/20 $ 11,111 $ - $ 11,111 Pulmonary Irvin, Charles G Dartmouth College Irvin - Dartmouth sub 07/01/21 06/30/26 $ 59,385 $ 33,255 $ 92,640 Pulmonary Kaminsky, David A American Lung Association Kaminsky ALA COVID 07/01/20 06/30/22 $ 162,813 $ - $ 162,813 Beta Blockers for the Prevention of Acute Pulmonary Kaminsky, David A University of Alabama at Birmingham 10/01/19 09/30/20 $ 32,428 $ 9,080 $ 41,508 Exacerbations of COPD Pulmonary Kaminsky, David A University of Alabama at Birmingham 33098 Kaminsky Observational study 10/01/20 09/30/21 $ 50,781 $ 14,219 $ 65,000 A Phase 1 Trial of Intratumoral Cisplatin as Pulmonary Kinsey, Charles American Lung Association Neoadjuvant Therapy for Immune Checkpoint 07/01/20 06/30/21 $ 74,578 $ - $ 74,578 Blockade CT Characteristics of Emphysema for Evaluation of Pulmonary Kinsey, Charles Natl Heart Lung and Blood Inst/NHLBI/NIH 07/01/19 06/30/20 $ 127,462 $ 10,197 $ 137,659 Pulmonary Nodules Pulmonary Kinsey, Charles Natl Inst Biomedical Imaging/NIBIB/NIH Optimizing Intratumoral Cisplatin Delivery 07/01/20 06/30/21 $ 490,758 $ 241,642 $ 732,400 Damon Runyon Cancer Research EBUS-TBNI of Cisplatin Optimization in Pulmonary Mori, Vitor 04/01/20 03/31/21 $ 78,000 $ - $ 78,000 Foundation Heterogeneous Lung Tumors Obese Allergic Asthma and the Impact of Weight Pulmonary Poynter, Matthew Edward Natl Heart Lung and Blood Inst/NHLBI/NIH 07/01/19 06/30/20 $ 499,677 $ 279,819 $ 779,496 Loss on Airway Epithelial Function A Randomized Controlled Trial of a Combined Nutrition (Protein Supplementation) and EXercISe Pulmonary Stapleton, Renee D. Baxter Healthcare Corporation 09/11/19 02/28/21 $ 16,667 $ 3,333 $ 20,000 Intervention in Mechanically Ventilated Critically Ill Patients the NEXIS Trial Pulmonary Stapleton, Renee D. Brigham and Women's Hospital Stapleton BWH 33232 supplement 07/01/20 06/30/21 $ 99,907 $ 55,948 $ 155,855 Pulmonary Stapleton, Renee D. National Institutes of Health/NIH 32723 NEXIS-FLAME supplement 07/01/20 06/30/22 $ 128,882 $ - $ 128,882 Pulmonary Stapleton, Renee D. Natl Heart Lung and Blood Inst/NHLBI/NIH 31438 Stapleton COVID-19 supplement 06/01/20 03/31/22 $ 1,216,789 $ 368,204 $ 1,584,993

Page 5 of 6 Department of Medicine FY2020 External UVM Research Applications Submitted By Division By PI

Requested Requested Requested Requested Requested Division PI Sponsor Project Title Start Date End date Direct Costs Indirect Costs Total

Effects of Exercise on Inflammation-Induced Lung Pulmonary Suratt, Benjamin T Natl Heart Lung and Blood Inst/NHLBI/NIH 07/01/19 06/30/20 $ 594,320 $ 183,286 $ 777,605 and Muscle Injury in Critical Illness (NEXIS-FLAME)

The Effects of Insulin and Chronic Hyperglycemia Pulmonary Suratt, Benjamin T Natl Heart Lung and Blood Inst/NHLBI/NIH 07/01/20 06/30/21 $ 75,000 $ 42,000 $ 117,000 on ARDS Pathogenesis and Outcomes

Pulmonary Teneback, Charlotte C Cystic Fibrosis Fdtn Therapeutics, Inc Cystic Fibrosis Foundation Research Support 12/01/19 03/31/20 $ 5,996 $ 480 $ 6,476 Pulmonary Teneback, Charlotte C Cystic Fibrosis Fdtn Therapeutics, Inc Therapeutics Development Center 01/01/20 03/31/20 $ - $ 1,828 $ 1,828 Pulmonary Teneback, Charlotte C Cystic Fibrosis Fdtn Therapeutics, Inc Therapeutics Development Center 04/01/20 03/31/21 $ 115,660 $ 9,253 $ 124,913 Pulmonary Weiss, Daniel J American Lung Association Weiss ALA COVID 07/01/20 06/30/22 $ 200,000 $ - $ 200,000 The ARDS Inflammatory Lung Environment Alters Pulmonary Weiss, Daniel J Athersys, Inc. MAPC Behaviors and Functions: Critical 12/01/19 11/30/20 $ 150,000 $ 84,000 $ 234,000 Implications for Potential Clinical Therapeutics Pulmonary Weiss, Daniel J Carnegie Mellon University Weiss CMU subcontract 11/01/20 10/31/22 $ 50,000 $ 6,000 $ 56,000 Pulmonary Weiss, Daniel J Cystic Fibrosis Foundation Enhancing Cell Delivery to the Lungs 02/01/20 01/31/21 $ 521,197 $ 32,144 $ 553,341 CF Lung Inflammatory Environment Effects on Pulmonary Weiss, Daniel J Cystic Fibrosis Foundation 05/01/20 04/30/21 $ 125,000 $ 15,000 $ 140,000 Mesenchymal Stromal Cells Repair and Regeneration of Pulmonary Injuries Pulmonary Weiss, Daniel J Dimension Inx. and Defects Through Combination ECM Hydrogels 09/01/20 08/31/21 $ 97,210 $ 54,437 $ 151,647 and 3D-Printed Ultra-Porous Biomaterials Pulmonary Weiss, Daniel J Dimension Inx. Weiss Dimension DOD 09/01/20 02/28/22 $ 84,535 $ 47,340 $ 131,875 Effects of Human Lung Derived Hydrogel Organoid Pulmonary Weiss, Daniel J National Institutes of Health/NIH 07/01/20 06/30/21 $ 125,000 $ 66,175 $ 191,175 Culture on Lung Progenitor Cell Behaviors Stem Cells, Therapies, and Bioengineering in Lung Pulmonary Weiss, Daniel J United Therapeutics Corporation 07/15/19 07/18/19 $ 3,623 $ 1,377 $ 5,000 Biology Conference Ex Vivo Bioengineering of Functional Biomimetic Pulmonary Weiss, Daniel J University of Connecticut Airways for Treatment of Neonatal and Pediatric 09/01/20 08/31/21 $ 24,781 $ 13,877 $ 38,658 Respiratory Conditions Pulmonary Weiss, Daniel J US Department of Defense/DOD Weiss Bird Lung DOD 11/01/20 10/31/23 $ 1,595,372 $ 655,409 $ 2,250,781 Pulmonary Weiss, Daniel J US Department of Defense/DOD Weiss DOD with Athersys 11/01/20 10/31/23 $ 946,672 $ 530,137 $ 1,476,809 Laminin Supported Junction Formation in Pulmonary Weiss, Daniel J Virginia Commonwealth University 09/01/20 08/31/21 $ 76,999 $ 43,119 $ 120,118 Engineered Decellularized Lung Tissues Medicine Total $ 40,206,706 $ 15,735,598 $ 55,942,305

Page 6 of 6 Department of Medicine FY2020 External UVM Research Applications Submitted by DOM Faculty

Department FY19 Count FY19 Dollars FY20 Count FY20 Dollars $ Change % Change

Cardiology 15 $3,088,766 15 $5,898,319 $2,809,553 91.0% Dermatology 1 $2,000 0 $0 -$2,000 n/a Endocrinology 3 $288,155 2 $889,976 $601,821 208.9% Gastroenterology 1 $77,489 0 $0 -$77,489 n/a Gen Internal Med 7 $1,372,684 15 $11,679,892 $10,307,208 750.9% Hematology Oncology (includes through VCC) 18 $4,531,657 35 $16,804,967 $12,273,310 270.8% Immunobiology 27 $8,559,487 13 $4,829,445 -$3,730,042 -43.6% Infectious Disease 3 $626,049 3 $908,876 $282,827 45.2% Nephrology 3 $115,999 3 $201,698 $85,699 73.9% Pulmonary 41 $11,495,883 46 $14,729,132 $3,233,249 28.1%

Medicine Total 119 $30,158,169 132 $55,942,305 $25,784,136 85.5%

Page 1 of 1 Department of Medicine UVM Research Funding (Direct & Indirect), FY16-FY20

$39,020,893

$18,925,948 $17,629,335 $17,452,377 $16,060,209

FY16 FY17 FY18 FY19 FY20 Department of Medicine UVM Research Funding (Direct & Indirect) by Division, FY2016-FY2020

Card Derm Endo Geriatrics GIMR GI Hem/Onc ID Immuno Neph Pulm FY16 $2,467,393 $545,000 $19,266,749 $28,003 $3,056,743 $8,060,121 $1,470,023 $2,855 $4,124,006 FY17 $3,228,439 $902,901 $20,000 $1,322,344 $3,359,832 $4,557,661 $4,878 $5,529,893 FY18 $2,600,927 $19,405 $20,001 $1,541,976 $3,148,250 $2,802,232 $5,927,418 FY19 $1,303,415 $39,757 $139,849 $135,055 $20,000 $1,591,123 $1,482,128 $3,100,088 $194,611 $9,623,309 FY20 $1,780,617 $2,000 $20,099 $652,837 $55,574 $3,338,362 $907,387 $2,457,859 $68,957 $8,168,685 Department of Medicine UVM Medical Center Research Revenue (Direct & Indirect), FY16-FY20

$3,430,100 $3,243,560

$2,908,420

$2,363,986 $2,196,358

2016 2017 2018 2019 2020