Rabbit Anti-Human STAM2 (Phospho-Tyr192) Polyclonal Antibody (CABT-L4115) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Rabbit Anti-Human STAM2 (Phospho-Tyr192) polyclonal antibody (CABT-L4115) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview This antibody detects endogenous levels of STAM2 only when phosphorylated at Tyr192.

Specificity Target Modification: Phospho. Modification Sites: Human: Y192; Mouse: Y192

Target Human STAM2 (Phospho-Tyr192)

Immunogen The antiserum was produced against synthesized peptide derived from human STAM2 around the phosphorylation site of Tyr192. Immunogen range: 161-210

Isotype IgG

Source/Host Rabbit

Species Reactivity Human, Mouse

Purification Affinity Purified

Conjugate Unconjugated

Applications WB, ELISA

Molecular Weight 58 kDa

Preparation The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Format Liquid

Concentration Lot specific

Buffer Rabbit IgG in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl and 50% glycerol.

Preservative 0.02% Sodium Azide

Storage Stable at -20°C for at least 1 year.

Ship Wet ice

Warnings For research use only.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Introduction The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.

Keywords STAM2;signal transducing adaptor molecule (SH3 domain and ITAM motif) 2;Hbp;STAM2A;STAM2B;signal transducing adapter molecule 2;STAM-2;HSE1 homolog;Hrs- binding protein;STAM-like protein containing SH3 and ITAM domains 2;

GENE INFORMATION

Gene Name STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [ Homo sapiens (human) ]

Official Symbol STAM2

Synonyms HBP, HRS binding protein, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, Signal transducing adaptor molecule 2A, Signal transducing adaptor molecule 2B

Entrez Gene ID 8986

UniProt ID O75886

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]