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Polyclonal Anti-EIF2S1

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Polyclonal Anti-EIF2S1 BOSTER BIOLOGICAL TECHNOLOGY Co.,Ltd. 3942 B Valley Ave, Pleasanton, CA, 94566 Phone: 888-466-3604 Fax: 925-215-2184 Email: [email protected] Web: www.bosterbio.com Polyclonal Anti-CADM1 Antibody Catalog Number: PA2294 Description Gene Name cell adhesion molecule 1 Recommended Protein Name Cell adhesion molecule 1 Lot No. 0221412c019431 Size 100μg/vial Form lyophilized Ig type Rabbit IgG Specificity No cross reactivity with other proteins. Purification Immunogen affinity purified. Reacts with: human, rat Species Predicted to work with: mouse A synthetic peptide corresponding to a sequence at the N-terminus of human Immunogen CADM1(73-92aa VIQLLNPNRQTIYFRDFRPL), identical to the related mouse and rat sequences. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Contents Thimerosal, 0.05mg NaN3. Application Concentration Tested Species Predicted Species Antigen Retrieval Western blot 0.1-0.5μg/ml Hu, Rat Ms - Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. Preparation and storage Reconstitution: 0.2ml of distilled water will yield a concentration of 500μg/ml. Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. 1 www.bosterbio.com Relevant detection systems Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB. Background Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene. This gene is also known as IGSF4, SYNCAM or TSLC1, and it is mapped to 11q23.3. CADM1 functions as a homophilic cell adhesion molecule at the synapse. Expression of the isolated cytoplasmic tail of CADM1 in neurons inhibited synapse assembly. Conversely, expression of full-length CADM1 in nonneuronal cells induced synapse formation by cocultured hippocampal neurons with normal release properties. CADM1 has been shown to interact with EPB41L3. Reference 1. Biederer, T., Sara, Y., Mozhayeva, M., Atasoy, D., Liu, X., Kavalali, E. T., Sudhof, T. C.SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297: 1525-1531, 2002. 2. Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (Feb 2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2". Genomics 62 (2): 139–46. 3. Yageta, Mika; Kuramochi Masami, Masuda Mari, Fukami Takeshi, Fukuhara Hiroshi, Maruyama Tomoko, Shibuya Masabumi, Murakami Yoshinori (Sep 2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. (United States) 62 (18): 5129–33. 2 FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC AND CLINICAL USE. Product Information Sheet .
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