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Home , ADAM10, ADCY3, ADCY4, ADCY5, ADCY8, ARF6

Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

Supplementary Table 1: Plasma Membrane Identifications from Bone Marrow Mesenchymal Stem Cells

Symbol Name Type ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 transporter ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 transporter ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 transporter ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 transporter ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 transporter ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 transporter ACE I converting (peptidyl-dipeptidase A) 1 peptidase ACTR2 ARP2 -related protein 2 homolog (yeast) other ACVR1 activin A , type I kinase ACVRL1 activin A receptor type II-like 1 kinase ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma) peptidase ADAM10 ADAM metallopeptidase domain 10 peptidase ADAM17 ADAM metallopeptidase domain 17 peptidase ADAM19 ADAM metallopeptidase domain 19 (meltrin beta) peptidase ADAM22 ADAM metallopeptidase domain 22 peptidase ADAM21 ADAM metallopeptidase domain 21 peptidase ADCY1 adenylate 1 (brain) enzyme ADCY3 adenylate cyclase 3 enzyme ADCY5 adenylate cyclase 5 enzyme aminoacyl tRNA synthetase complex-interacting multifunctional AIMP2 protein 2 other ALK anaplastic lymphoma receptor kinase ANXA1 A1 other ANXA2 annexin A2 other ANXA4 annexin A4 other ANXA5 annexin A5 other ANXA6 annexin A6 other AOC3 amine oxidase, copper containing 3 (vascular adhesion protein 1) enzyme ARF6 ADP-ribosylation factor 6 transporter ATP10B ATPase, class V, type 10B transporter ATP11B ATPase, class VI, type 11B transporter ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide transporter ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide transporter ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide transporter ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 transporter ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 transporter ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 transporter ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 transporter ATP8B2 ATPase, class I, type 8B, member 2 transporter ATP9A ATPase, class II, type 9A transporter G-protein BAI3 brain-specific angiogenesis inhibitor 3 coupled receptor BASP1 brain abundant, membrane attached signal protein 1 other BCAR1 breast anti-estrogen resistance 1 other BEST4 bestrophin 4 other Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

BMPR1A bone morphogenetic protein receptor, type IA kinase BRP44 brain protein 44 other BVES blood vessel epicardial substance other C20ORF3 20 open reading frame 3 other CA12 XII enzyme CACNA1A , voltage-dependent, P/Q type, alpha 1A subunit CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit ion channel CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit ion channel CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit ion channel CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit ion channel calcium/-dependent serine (MAGUK CASK family) kinase G-protein CASR calcium-sensing receptor coupled receptor CAV1 1, protein, 22kDa other CAV2 caveolin 2 other G-protein CCKBR cholecystokinin B receptor coupled receptor CD22 CD22 molecule other CD44 CD44 molecule (Indian blood group) other CD63 CD63 molecule other CD74 molecule, major histocompatibility complex, class II transmembrane CD74 invariant chain receptor CD81 CD81 molecule other CDH1 1, type 1, E-cadherin (epithelial) other CDH2 cadherin 2, type 1, N-cadherin (neuronal) other CDH6 cadherin 6, type 2, K-cadherin (fetal ) other CDH23 cadherin-like 23 transporter CDH4 cadherin 4, type 1, R-cadherin (retinal) other cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo G-protein CELSR1 homolog, Drosophila) coupled receptor cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo G-protein CELSR3 homolog, Drosophila) coupled receptor CGN cingulin other transmembrane CHRNA9 cholinergic receptor, nicotinic, alpha 9 receptor transmembrane CHRND cholinergic receptor, nicotinic, delta receptor CLCN1 1, ion channel CLCN6 chloride channel 6 ion channel CLCN7 chloride channel 7 ion channel CLEC4F C-type domain family 4, member F other CLSTN1 calsyntenin 1 other CLTC , heavy chain (Hc) other CLTCL1 clathrin, heavy chain-like 1 other CNGA1 gated channel alpha 1 ion channel CNGA3 cyclic nucleotide gated channel alpha 3 ion channel CNGB1 cyclic nucleotide gated channel beta 1 ion channel CNTNAP1 contactin associated protein 1 other CORIN corin, serine peptidase peptidase CPM carboxypeptidase M peptidase CR2 complement component (3d/Epstein Barr virus) receptor 2 transmembrane Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

receptor CRIP2 cysteine-rich protein 2 other colony stimulating factor 2 receptor, beta, low-affinity transmembrane CSF2RB (granulocyte-) receptor CTNNA1 (cadherin-associated protein), alpha 1, 102kDa other catenin (cadherin-associated protein), delta 2 (neural - CTNND2 related arm-repeat protein) other DCHS1 dachsous 1 (Drosophila) other DMD other DNM2 2 enzyme DSC3 desmocollin 3 other DSCAM Down syndrome molecule other DSG2 2 other DSG3 desmoglein 3 (pemphigus vulgaris antigen) other DST other DTNB , beta other , limb girdle 2B (autosomal DYSF recessive) other EFNB2 -B2 other EFR3A EFR3 homolog A (S. cerevisiae) other epidermal receptor (erythroblastic leukemia viral (v- EGFR erb-b) oncogene homolog, avian) kinase EHD4 EH-domain containing 4 enzyme ENG other ENPP1 ectonucleotide / 1 enzyme EPB41L1 erythrocyte band 4.1-like 1 other EPB41L2 erythrocyte membrane protein band 4.1-like 2 other EPB41L3 erythrocyte membrane protein band 4.1-like 3 other EPHA4 EPH receptor A4 kinase EPHA8 EPH receptor A8 kinase EPHB2 EPH receptor B2 kinase EPHB3 EPH receptor B3 kinase EPHB4 EPH receptor B4 kinase EPS8 epidermal pathway substrate 8 peptidase ERLIN2 ER lipid raft associated 2 other EVPL other EXOC3 exocyst complex component 3 transporter EXOC7 exocyst complex component 7 transporter G-protein F2R coagulation factor II (thrombin) receptor coupled receptor FAAH fatty acid amide enzyme transmembrane FAS Fas (TNF receptor superfamily, member 6) receptor FAT1 FAT tumor suppressor homolog 1 (Drosophila) other FAT2 FAT tumor suppressor homolog 2 (Drosophila) other FGFR1 receptor 1 kinase FGFR2 fibroblast growth factor receptor 2 kinase FGFR3 fibroblast growth factor receptor 3 kinase FLOT1 flotillin 1 other FLOT2 flotillin 2 other FN1 fibronectin 1 Enzyme FYN FYN oncogene related to SRC, FGR, YES kinase Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

G-protein FZD7 frizzled homolog 7 (Drosophila) coupled receptor GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 ion channel GAS1 growth arrest-specific 1 other GJA1 protein, alpha 1, 43kDa transporter G-protein GLP1R glucagon-like peptide 1 receptor coupled receptor GNA13 guanine nucleotide binding protein (), alpha 13 enzyme guanine nucleotide binding protein (G protein), alpha inhibiting GNAI2 activity polypeptide 2 enzyme GNAS GNAS complex enzyme GNG4 guanine nucleotide binding protein (G protein), gamma 4 enzyme GNG12 guanine nucleotide binding protein (G protein), gamma 12 enzyme GP5 glycoprotein V (platelet) other transmembrane GPC1 glypican 1 receptor GRIA2 , ionotropic, AMPA 2 ion channel GRID1 glutamate receptor, ionotropic, delta 1 ion channel GRIK1 glutamate receptor, ionotropic, kainate 1 ion channel GRIK3 glutamate receptor, ionotropic, kainate 3 ion channel GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D ion channel G-protein GRM2 glutamate receptor, metabotropic 2 coupled receptor G-protein GRM3 glutamate receptor, metabotropic 3 coupled receptor G-protein GRM6 glutamate receptor, metabotropic 6 coupled receptor G-protein GRM7 glutamate receptor, metabotropic 7 coupled receptor GUCY2D 2D, membrane (-specific) kinase GYPC (Gerbich blood group) other HAS1 hyaluronan synthase 1 enzyme hyperpolarization activated cyclic nucleotide-gated potassium HCN3 channel 3 ion channel transmembrane HLA-A major histocompatibility complex, class I, A receptor transmembrane HLA-B major histocompatibility complex, class I, B receptor transmembrane HLA-C major histocompatibility complex, class I, C receptor transmembrane HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 receptor HOMER3 homer homolog 3 (Drosophila) other HSPG2 heparan sulfate 2 other G-protein HTR1D 5-hydroxytryptamine (serotonin) receptor 1D coupled receptor ICAM5 intercellular adhesion molecule 5, telencephalin other ICOSLG inducible T-cell co-stimulator ligand other transmembrane IGF1R -like growth factor 1 receptor receptor transmembrane IGF2R insulin-like growth factor 2 receptor receptor transmembrane IL10RB 10 receptor, beta receptor Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

transmembrane IL13RA1 interleukin 13 receptor, alpha 1 receptor transmembrane IL1RL1 interleukin 1 receptor-like 1 receptor transmembrane IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) receptor INSR kinase INSRR insulin receptor-related receptor kinase IRAK1 interleukin-1 receptor-associated kinase 1 kinase ITGA1 , alpha 1 other ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) other integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 ITGA3 receptor) other ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) other ITGA7 integrin, alpha 7 other ITGA11 integrin, alpha 11 other integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen ITGAV CD51) other integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen transmembrane ITGB1 CD29 includes MDF2, MSK12) receptor integrin, beta 2 (complement component 3 receptor 3 and 4 ITGB2 subunit) other ITGB5 integrin, beta 5 other JPH3 junctophilin 3 other potassium voltage-gated channel, Shaw-related subfamily, KCNC3 member 3 ion channel KCNF1 potassium voltage-gated channel, subfamily F, member 1 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH2 member 2 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH3 member 3 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH4 member 4 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH5 member 5 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH6 member 6 ion channel KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6 ion channel KCNK10 , subfamily K, member 10 ion channel potassium intermediate/small conductance calcium-activated KCNN3 channel, subfamily N, member 3 ion channel KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3 ion channel KDR kinase insert domain receptor (a type III ) kinase KLRA6 killer cell lectin-like receptor, subfamily A, member 6 other LAMP2 lysosomal-associated membrane protein 2 enzyme LDLR low density lipoprotein receptor transporter transmembrane LIFR leukemia inhibitory factor receptor alpha receptor LIMS1 LIM and senescent cell antigen-like domains 1 other low density lipoprotein-related protein 1 (alpha-2-macroglobulin transmembrane LRP1 receptor) receptor LRP2 low density lipoprotein-related protein 2 transporter LRRC15 rich repeat containing 15 other Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

G-protein LTB4R2 leukotriene B4 receptor 2 coupled receptor LY75 antigen 75 other MAGED2 melanoma antigen family D, 2 other membrane associated guanylate kinase, WW and PDZ domain MAGI2 containing 2 kinase transmembrane MARCO macrophage receptor with collagenous structure receptor antigen p97 (melanoma associated) identified by monoclonal MFI2 antibodies 133.2 and 96.5 other MLEC malectin other MME membrane metallo-endopeptidase peptidase MPP1 membrane protein, palmitoylated 1, 55kDa kinase MSN moesin other MYH4 , heavy chain 4, skeletal muscle other NCAM1 neural 1 other NCKAP1 NCK-associated protein 1 other NCSTN nicastrin peptidase NEU3 sialidase 3 (membrane sialidase) enzyme NFASC neurofascin homolog (chicken) other NKTR natural killer-tumor recognition sequence other NOTCH3 Notch homolog 3 (Drosophila) regulator natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic G-protein NPR2 peptide receptor B) coupled receptor natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic G-protein NPR3 peptide receptor C) coupled receptor NRXN1 1 transporter NRXN2 neurexin 2 transporter NT5E 5'-nucleotidase, ecto (CD73) phosphatase transmembrane OPCML opioid binding protein/cell adhesion molecule-like receptor G-protein OPRM1 opioid receptor, mu 1 coupled receptor OTOF other G-protein OXTR oxytocin receptor coupled receptor PARD3 par-3 partitioning defective 3 homolog (C. elegans) other PCDH7 protocadherin 7 other PCDHA9 protocadherin alpha 9 other PCDHB10 protocadherin beta 10 other PDGFRB platelet-derived growth factor receptor, beta polypeptide kinase PECAM1 platelet/endothelial cell adhesion molecule other PGRMC1 progesterone receptor membrane component 1 other PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) other PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) other PKP3 plakophilin 3 other PPIL1 peptidylprolyl (cyclophilin)-like 1 enzyme transmembrane PRLR prolactin receptor receptor PSEN1 1 peptidase transmembrane PTCH1 patched homolog 1 (Drosophila) receptor Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

PTGFRN prostaglandin F2 receptor negative regulator other PTPRC protein tyrosine phosphatase, receptor type, C phosphatase PTPRG protein tyrosine phosphatase, receptor type, G phosphatase PTPRN protein tyrosine phosphatase, receptor type, N phosphatase PTPRV protein tyrosine phosphatase, receptor type, V () phosphatase RAB13 RAB13, member RAS oncogene family enzyme RAB2B RAB2B, member RAS oncogene family enzyme RHEB Ras homolog enriched in brain enzyme RHOC ras homolog gene family, member C enzyme transmembrane RPSA ribosomal protein SA receptor RRAS2 related RAS viral (r-ras) oncogene homolog 2 enzyme RYK RYK receptor-like tyrosine kinase kinase RYR3 3 ion channel SCARB2 scavenger receptor class B, member 2 other transmembrane SCARF2 scavenger receptor class F, member 2 receptor SCN1A , voltage-gated, type I, alpha subunit ion channel SCNN1A sodium channel, nonvoltage-gated 1 alpha ion channel SCNN1G sodium channel, nonvoltage-gated 1, gamma ion channel SDC4 syndecan 4 other sema domain, transmembrane domain (TM), and cytoplasmic SEMA6A domain, (semaphorin) 6A other semaphorin 7A, GPI membrane anchor (John Milton Hagen blood SEMA7A group) other SERINC1 serine incorporator 1 transporter SIGLEC1 sialic acid binding Ig-like lectin 1, other SIRPA signal-regulatory protein alpha phosphatase SLA Src-like-adaptor other solute carrier family 10 (sodium/bile acid cotransporter family), SLC10A1 member 1 transporter solute carrier family 11 (proton-coupled divalent metal ion SLC11A2 transporters), member 2 transporter solute carrier family 12 (sodium/potassium/chloride transporters), SLC12A1 member 1 transporter solute carrier family 12 (sodium/potassium/chloride transporters), SLC12A2 member 2 transporter solute carrier family 12 (potassium/chloride transporters), member SLC12A4 4 transporter solute carrier family 12 (potassium/chloride transporters), member SLC12A6 6 transporter solute carrier family 12 (potassium/chloride transporters), member SLC12A7 7 transporter solute carrier family 16, member 1 (monocarboxylic acid SLC16A1 transporter 1) transporter solute carrier family 16, member 3 (monocarboxylic acid SLC16A3 transporter 4) transporter solute carrier family 16, member 7 (monocarboxylic acid SLC16A7 transporter 2) transporter solute carrier family 1 (glutamate/neutral transporter), SLC1A4 member 4 transporter SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 transporter SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), transporter Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

member 1 solute carrier family 25 (mitochondrial carrier; citrate transporter), SLC25A1 member 1 transporter SLC26A2 solute carrier family 26 (sulfate transporter), member 2 transporter SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 transporter SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 transporter SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 transporter SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 transporter SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 transporter SLC30A1 solute carrier family 30 (zinc transporter), member 1 transporter SLC39A2 solute carrier family 39 (zinc transporter), member 2 transporter solute carrier family 3 (activators of dibasic and neutral amino SLC3A2 acid transport), member 2 transporter SLC4A3 solute carrier family 4, anion exchanger, member 3 transporter SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 transporter SLC6A16 solute carrier family 6, member 16 transporter solute carrier family 7 (cationic amino acid transporter, y+ SLC7A2 system), member 2 transporter solute carrier family 7 (cationic amino acid transporter, y+ SLC7A5 system), member 5 transporter SLC9A1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 ion channel SLCO1A1 solute carrier organic anion transporter family, member 1a1 transporter SNAP23 synaptosomal-associated protein, 23kDa transporter SNPH syntaphilin other , beta 2 (dystrophin-associated protein A1, 59kDa, SNTB2 basic component 2) other SORCS2 sortilin-related VPS10 domain containing receptor 2 transporter SPAG9 sperm associated antigen 9 other SPTAN1 , alpha, non-erythrocytic 1 (alpha-fodrin) other SPTB spectrin, beta, erythrocytic other SPTBN5 spectrin, beta, non-erythrocytic 5 other STEAP1 six transmembrane epithelial antigen of the prostate 1 transporter STIM2 stromal interaction molecule 2 other STOM stomatin other STON1 stonin 1 other STRAP serine/threonine kinase receptor associated protein other STX3 3 transporter STX7 syntaxin 7 transporter STX8 syntaxin 8 other STX12 syntaxin 12 other STXBP3 syntaxin binding protein 3 transporter SYN3 III other TBL2 (beta)-like 2 other TEK TEK tyrosine kinase, endothelial kinase TES testis derived transcript (3 LIM domains) other TGFBR2 transforming growth factor, beta receptor II (70/80kDa) kinase transglutaminase 1 (K polypeptide epidermal type I, protein- TGM1 glutamine-gamma-glutamyltransferase) enzyme TJP1 (zona occludens 1) other TJP2 (zona occludens 2) kinase TJP3 tight junction protein 3 (zona occludens 3) other TLN1 1 other Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

TM9SF2 transmembrane 9 superfamily member 2 transporter TMC1 transmembrane channel-like 1 other TMC2 transmembrane channel-like 2 other transmembrane TNFRSF10B tumor necrosis factor receptor superfamily, member 10b receptor

TNFRSF12A tumor necrosis factor receptor superfamily, member 12A other TRIO triple functional domain (PTPRF interacting) kinase transient receptor potential cation channel, subfamily C, member TRPC1 1 ion channel transient receptor potential cation channel, subfamily C, member TRPC3 3 ion channel transient receptor potential cation channel, subfamily M, member TRPM3 3 ion channel G-protein TSHR thyroid stimulating hormone receptor coupled receptor TSPAN3 3 other TSTA3 tissue specific transplantation antigen P35B enzyme TTC7A tetratricopeptide repeat domain 7A other TYRO3 TYRO3 protein tyrosine kinase kinase USP9X specific peptidase 9, X-linked peptidase VAMP3 vesicle-associated membrane protein 3 (cellubrevin) other VAMP (vesicle-associated membrane protein)-associated protein VAPB B and C other VASP vasodilator-stimulated phosphoprotein other VCAM1 vascular cell adhesion molecule 1 other VCL enzyme VLDLR very low density lipoprotein receptor transporter XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound peptidase G-protein XPR1 xenotropic and polytropic retrovirus receptor coupled receptor ZYX zyxin other Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

Supplementary Table 2: Plasma Membrane Protein Identifications from Human Dermal Fibroblasts

Symbol Entrez Gene Name Type ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 transporter ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 transporter ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 transporter ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 transporter ACTR2 ARP2 actin-related protein 2 homolog (yeast) other ADAM7 ADAM metallopeptidase domain 7 peptidase ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma) peptidase ADAM10 ADAM metallopeptidase domain 10 peptidase ADCY4 adenylate cyclase 4 enzyme ADCY8 adenylate cyclase 8 (brain) enzyme

transmembrane ADIPOR1 1 receptor

transmembrane AGER advanced glycosylation end product-specific receptor receptor AGRN agrin other aminoacyl tRNA synthetase complex-interacting AIMP2 multifunctional protein 2 other ALK anaplastic lymphoma receptor tyrosine kinase kinase ANXA1 annexin A1 other ANXA2 annexin A2 other ANXA4 annexin A4 other ANXA5 annexin A5 other ANXA6 annexin A6 other APP amyloid beta (A4) precursor protein other ARVCF armadillo repeat gene deletes in velocardiofacial syndrome other ATP10A ATPase, class V, type 10A transporter ATP10B ATPase, class V, type 10B transporter ATP11B ATPase, class VI, type 11B transporter ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide transporter ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide transporter ATP2B1 ATPase, Ca++ transporting, PM 1 transporter ATP2B2 ATPase, Ca++ transporting, PM 2 transporter ATP2B3 ATPase, Ca++ transporting, PM 3 transporter ATP2B4 ATPase, Ca++ transporting, PM 4 transporter ATP7A ATPase, Cu++ transporting, alpha polypeptide transporter AXL AXL receptor tyrosine kinase kinase G-protein coupled BAI1 brain-specific angiogenesis inhibitor 1 receptor BASP1 brain abundant, membrane attached signal protein 1 other BCAR1 breast cancer anti-estrogen resistance 1 other C20ORF3 open reading frame 3 other CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A ion channel Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

subunit calcium channel, voltage-dependent, N type, alpha 1B CACNA1B subunit ion channel CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit ion channel calcium channel, voltage-dependent, T type, alpha 1G CACNA1G subunit ion channel CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 ion channel CAV1 , caveolae protein, 22kDa other

transmembrane CD5 CD5 molecule receptor CD44 CD44 molecule (Indian blood group) other CD48 CD48 molecule other CD63 CD63 molecule other CD81 CD81 molecule other CDH2 cadherin 2, type 1, N-cadherin (neuronal) other CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) other CDH22 cadherin-like 22 other CDH23 cadherin-like 23 transporter G-protein cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo coupled CELSR1 homolog, Drosophila) receptor G-protein cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo coupled CELSR2 homolog, Drosophila) receptor G-protein cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo coupled CELSR3 homolog, Drosophila) receptor cystic fibrosis transmembrane conductance regulator (ATP- CFTR binding cassette sub-family C, member 7) ion channel CLCN7 chloride channel 7 ion channel CLEC4F C-type lectin domain family 4, member F other CLTC clathrin, heavy chain (Hc) other CNGA3 cyclic nucleotide gated channel alpha 3 ion channel CNGB1 cyclic nucleotide gated channel beta 1 ion channel CNTNAP1 contactin associated protein 1 other CORIN corin, serine peptidase peptidase CSF1R colony stimulating factor 1 receptor kinase

colony stimulating factor 2 receptor, beta, low-affinity transmembrane CSF2RB (granulocyte-macrophage) receptor

transmembrane DAG1 1 (dystrophin-associated glycoprotein 1) receptor DCHS1 dachsous 1 (Drosophila) other DLG2 discs, large homolog 2 (Drosophila) kinase DLG3 discs, large homolog 3 (Drosophila) kinase DLG4 discs, large homolog 4 (Drosophila) kinase DLGAP4 discs, large (Drosophila) homolog-associated protein 4 other DMD dystrophin other DNM2 dynamin 2 enzyme DOK5 docking protein 5 other DPP4 dipeptidyl-peptidase 4 peptidase Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

DSC2 desmocollin 2 other DSCAM Down syndrome cell adhesion molecule other DSG2 desmoglein 2 other DST dystonin other DTNB dystrobrevin, beta other dysferlin, limb girdle muscular dystrophy 2B (autosomal DYSF recessive) other receptor (erythroblastic leukemia viral EGFR (v-erb-b) oncogene homolog, avian) kinase EHD4 EH-domain containing 4 enzyme G-protein egf-like module containing, mucin-like, hormone receptor-like coupled EMR1 1 receptor ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 enzyme EPB41L2 erythrocyte membrane protein band 4.1-like 2 other EPHA3 EPH receptor A3 kinase EPHA8 EPH receptor A8 kinase EPHB3 EPH receptor B3 kinase EPS8 epidermal growth factor receptor pathway substrate 8 peptidase ERLIN2 ER lipid raft associated 2 other EVI2B ecotropic viral integration site 2B other EVPL envoplakin other EXOC3 exocyst complex component 3 transporter FAM158A family with sequence similarity 158, member A other FAT1 FAT tumor suppressor homolog 1 (Drosophila) other FAT2 FAT tumor suppressor homolog 2 (Drosophila) other FGFR4 fibroblast growth factor receptor 4 kinase FLOT1 flotillin 1 other FLOT2 flotillin 2 other

transmembrane FLT4 fms-related tyrosine kinase 4 receptor FN1 fibronectin 1 enzyme FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 peptidase G-protein coupled FZD1 frizzled homolog 1 (Drosophila) receptor G-protein coupled FZD10 frizzled homolog 10 (Drosophila) receptor G-protein coupled GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 receptor GABRD gamma-aminobutyric acid (GABA) A receptor, delta ion channel GABRP gamma-aminobutyric acid (GABA) A receptor, pi ion channel

transmembrane GFRA2 GDNF family receptor alpha 2 receptor GJA3 , alpha 3, 46kDa transporter GJC1 gap junction protein, gamma 1, 45kDa transporter guanine nucleotide binding protein (G protein), alpha 11 (Gq GNA11 class) enzyme GNA13 guanine nucleotide binding protein (G protein), alpha 13 enzyme Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

guanine nucleotide binding protein (G protein), alpha GNAO1 activating activity polypeptide O enzyme GNAS GNAS complex locus enzyme GNG12 guanine nucleotide binding protein (G protein), gamma 12 enzyme GP5 glycoprotein V (platelet) other GPC2 glypican 2 other G-protein coupled GPR83 G protein-coupled receptor 83 receptor GRID2 glutamate receptor, ionotropic, delta 2 ion channel GRIK4 glutamate receptor, ionotropic, kainate 4 ion channel GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A ion channel GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B ion channel GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C ion channel GRK1 G protein-coupled receptor kinase 1 kinase G-protein coupled GRM6 glutamate receptor, metabotropic 6 receptor GUCY2D guanylate cyclase 2D, membrane (retina-specific) kinase GYPC glycophorin C (Gerbich blood group) other hyperpolarization activated cyclic nucleotide-gated potassium HCN3 channel 3 ion channel hyperpolarization activated cyclic nucleotide-gated potassium HCN4 channel 4 ion channel

transmembrane HLA-A major histocompatibility complex, class I, A receptor

transmembrane HNRNPM heterogeneous nuclear ribonucleoprotein M receptor HSPG2 (includes EG:3339) heparan sulfate proteoglycan 2 other

transmembrane IGF1R insulin-like growth factor 1 receptor receptor

transmembrane IGF2R insulin-like growth factor 2 receptor receptor

transmembrane IL12RB1 interleukin 12 receptor, beta 1 receptor

transmembrane IL12RB2 interleukin 12 receptor, beta 2 receptor

transmembrane IL1RAP interleukin 1 receptor accessory protein receptor

transmembrane IL1RAPL2 interleukin 1 receptor accessory protein-like 2 receptor

transmembrane IL1RL2 interleukin 1 receptor-like 2 receptor Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

transmembrane IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) receptor INSR insulin receptor kinase IRAK1 interleukin-1 receptor-associated kinase 1 kinase ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) other integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 ITGA3 receptor) other ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) other ITGA6 integrin, alpha 6 other ITGA8 integrin, alpha 8 other

integrin, beta 1 (fibronectin receptor, beta polypeptide, transmembrane ITGB1 antigen CD29 includes MDF2, MSK12) receptor

transmembrane ITGB4 integrin, beta 4 receptor JPH1 junctophilin 1 other JPH3 junctophilin 3 other potassium voltage-gated channel, -related subfamily, KCNA4 member 4 ion channel potassium voltage-gated channel, shaker-related subfamily, KCNA5 member 5 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH1 member 1 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH3 member 3 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH4 member 4 ion channel potassium voltage-gated channel, subfamily H (eag-related), KCNH7 member 7 ion channel KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 ion channel potassium inwardly-rectifying channel, subfamily J, member KCNJ16 16 ion channel potassium voltage-gated channel, KQT-like subfamily, KCNQ1 member 1 ion channel v- Hardy-Zuckerman 4 feline sarcoma viral oncogene KIT homolog kinase KLRA5 killer cell lectin-like receptor, subfamily A, member 5 other KRT6A 6A other

transmembrane LAG3 lymphocyte-activation gene 3 receptor LAMP2 lysosomal-associated membrane protein 2 enzyme LDLR low density lipoprotein receptor transporter

low density lipoprotein-related protein 1 (alpha-2- transmembrane LRP1 macroglobulin receptor) receptor LRP2 low density lipoprotein-related protein 2 transporter LTK leukocyte receptor tyrosine kinase kinase MAGED2 melanoma antigen family D, 2 other

transmembrane MARCO macrophage receptor with collagenous structure receptor Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

MME membrane metallo-endopeptidase peptidase

transmembrane MRC1 , C type 1 receptor

transmembrane MSR1 macrophage scavenger receptor 1 receptor MYD88 myeloid differentiation primary response gene (88) other MYO1D myosin ID other NCKAP1 NCK-associated protein 1 other NCSTN nicastrin peptidase transcription NEO1 neogenin homolog 1 (chicken) regulator NFASC neurofascin homolog (chicken) other NKTR natural killer-tumor recognition sequence other NLGN2 2 enzyme transcription NOTCH4 Notch homolog 4 (Drosophila) regulator G-protein natriuretic peptide receptor B/guanylate cyclase B coupled NPR2 (atrionatriuretic peptide receptor B) receptor

transmembrane NPTXR neuronal pentraxin receptor receptor NRCAM neuronal cell adhesion molecule other NRXN1 neurexin 1 transporter NRXN2 neurexin 2 transporter NT5E 5'-nucleotidase, ecto (CD73) phosphatase G-protein coupled OR13F1 , family 13, subfamily F, member 1 receptor OTOF otoferlin other PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) other PCDH8 protocadherin 8 other PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha enzyme PDGFRB platelet-derived growth factor receptor, beta polypeptide kinase PGRMC1 progesterone receptor membrane component 1 other POTED POTE domain family, member D other PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) other PSEN1 presenilin 1 peptidase PTPRB protein tyrosine phosphatase, receptor type, B phosphatase PTPRT protein tyrosine phosphatase, receptor type, T phosphatase RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 other RAPSN receptor-associated protein of the synapse other RASA3 RAS p21 protein activator 3 other RET ret proto-oncogene kinase RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 kinase RPH3A rabphilin 3A homolog (mouse) transporter

transmembrane RPSA ribosomal protein SA receptor RYR3 ryanodine receptor 3 ion channel Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

SCARB2 scavenger receptor class B, member 2 other SDC4 syndecan 4 other sema domain, (Ig), transmembrane SEMA4F domain (TM) and short cytoplasmic domain, (semaphorin) 4F other sema domain, transmembrane domain (TM), and cytoplasmic SEMA6B domain, (semaphorin) 6B other sema domain, transmembrane domain (TM), and cytoplasmic SEMA6C domain, (semaphorin) 6C other SGCB , beta (43kDa dystrophin-associated glycoprotein) other SHROOM2 shroom family member 2 ion channel SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin other SIGLEC12 sialic acid binding Ig-like lectin 12 other solute carrier family 12 (sodium/potassium/chloride SLC12A1 transporters), member 1 transporter solute carrier family 12 (sodium/potassium/chloride SLC12A2 transporters), member 2 transporter solute carrier family 12 (potassium/chloride transporters), SLC12A6 member 6 transporter solute carrier family 16, member 1 (monocarboxylic acid SLC16A1 transporter 1) transporter solute carrier family 16, member 3 (monocarboxylic acid SLC16A3 transporter 4) transporter SLC18A2 solute carrier family 18 (vesicular monoamine), member 2 transporter solute carrier family 1 (glial high affinity glutamate SLC1A2 transporter), member 2 transporter solute carrier family 1 (neutral amino acid transporter), SLC1A5 member 5 transporter solute carrier family 24 (sodium/potassium/calcium SLC24A1 exchanger), member 1 transporter solute carrier family 25 (mitochondrial carrier; citrate SLC25A1 transporter), member 1 transporter SLC26A1 solute carrier family 26 (sulfate transporter), member 1 transporter solute carrier family 2 (facilitated glucose transporter), SLC2A3 member 3 transporter SLC30A1 solute carrier family 30 (zinc transporter), member 1 transporter SLC34A1 solute carrier family 34 (sodium phosphate), member 1 transporter solute carrier family 3 (activators of dibasic and neutral amino SLC3A2 acid transport), member 2 transporter solute carrier family 4, anion exchanger, member 1 SLC4A1 (erythrocyte membrane protein band 3, Diego blood group) transporter solute carrier family 6 (neutral amino acid transporter), SLC6A15 member 15 transporter solute carrier family 7 (cationic amino acid transporter, y+ SLC7A1 system), member 1 transporter solute carrier family 9 (sodium/hydrogen exchanger), member SLC9A1 1 ion channel syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, SNTB2 basic component 2) other SNTG2 syntrophin, gamma 2 other SORL1 sortilin-related receptor, L(DLR class) A repeats-containing transporter SPAG9 sperm associated antigen 9 other SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) other SPTBN5 spectrin, beta, non-erythrocytic 5 other STEAP1 six transmembrane epithelial antigen of the prostate 1 transporter Supplementary Material (ESI) for Analytical Methods This journal is (C) The Royal Society of Chemistry 2010

STOM stomatin other SYN1 synapsin I transporter SYN3 synapsin III other TBL2 transducin (beta)-like 2 other TEK TEK tyrosine kinase, endothelial kinase TES testis derived transcript (3 LIM domains) other TFRC (p90, CD71) transporter TGFBR2 transforming growth factor, beta receptor II (70/80kDa) kinase transglutaminase 1 (K polypeptide epidermal type I, protein- TGM1 glutamine-gamma-glutamyltransferase) enzyme tyrosine kinase with immunoglobulin-like and EGF-like TIE1 domains 1 kinase TJP3 tight junction protein 3 (zona occludens 3) other TLN1 talin 1 other

transmembrane TLR8 toll-like receptor 8 receptor TMC2 transmembrane channel-like 2 other TNFRSF21 tumor necrosis factor receptor superfamily, member 21 other TNFRSF10A (includes transmembrane EG:8797) tumor necrosis factor receptor superfamily, member 10a receptor

transmembrane TNFRSF10B tumor necrosis factor receptor superfamily, member 10b receptor

transmembrane TNFRSF1B tumor necrosis factor receptor superfamily, member 1B receptor TPO thyroid peroxidase enzyme TRHDE thyrotropin-releasing hormone degrading enzyme peptidase TRIO triple functional domain (PTPRF interacting) kinase transient receptor potential cation channel, subfamily C, TRPC4 member 4 ion channel transient receptor potential cation channel, subfamily C, TRPC7 member 7 ion channel transient receptor potential cation channel, subfamily M, TRPM3 member 3 ion channel TSPAN3 tetraspanin 3 other TTC7A tetratricopeptide repeat domain 7A other TYK2 kinase VAMP (vesicle-associated membrane protein)-associated VAPB protein B and C other VASP vasodilator-stimulated phosphoprotein other VCL vinculin enzyme ZAP70 zeta-chain (TCR) associated protein kinase 70kDa kinase