Appendix A: List of insecticides to be considered in the systematic review

• Carbamates: Alanycarb, aldicarb, aminocarb, bendiocarb, benfuracarb, butocarboxim, butoxycar- boxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, fenothiocarb, fenoxycarb, for- metanate, furathiocarb, isolan, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, triazamate,trimethacarb, XMC, xylylcarb • Organophosphates: Acephate, amiton, azamethiphos, azinphos-ethyl, azinphosmethyl, cadusafos, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos, chlorpyrifos-methyl, coumaphos, crufomate, cyanophos, cyanofenphos, cythioate, demeton-S-methyl, diazinon, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, etrimfos, fam- phur, fenamiphos, fenitrothion, fenthion, fonofos, formothion, fosthiazate, fensulfothion, hep- tenophos, imicyafos, isofenphos, isopropyl O-(methoxyaminothio-phosphoryl) salicylate, isoxathi- on, leptophos, malaoxon, malathion, mecarbam, methacrifos, methamidophos, methidathion, mevinphos, mipafox, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion, parathi- on-methyl, phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupi- rimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, tributyl phosphorotrithioite, trichlorfon, vamidothion • Fiproles: Ethiprole, fipronil • Pyrethroids and pyrethrins: Acrinathrin, allethrin, bifenthrin, bioallethrin, bioresmethrin, cyclopro- thrin, cyfluthrin, cismethrin, cyhalothrin, cypermethrin, cyphenothrin, deltamethrin, empenthrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, tau-fluvalinate, halfenprox, imiprothrin, kadethrin, permethrin, phenothrin, prallethrin, pyrethrum, resmethrin, silafluofen, tefluthrin, tetramethrin, tralomethrin, transfluthrin • Neonicotinoids: Acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thia- cloprid, thiamethoxam • Sulfoximines: Sulfoxaflor • Butenolides: Flupyradifurone • Mesoionics: Triflumezopyrim • Spinosyns: Spinetoram, spinosad • Avermectins and milbemycins: Abamectin, emamectin benzoate, lepimectin, milbemectin • Pyridine azomethine derivatives: Pymetrozine, pyrifluquinazon • Flonicamid

Page 1 of 2 • Nereistoxin analogs: Bensultap, cartap hydrochloride, thiocyclam, thiosultap-sodium • Amitraz • Oxadiazines: Indoxacarb • Semicarbazones: Metaflumizone • Diamides: Chlorantraniliprole, cyantraniliprole, flubendiamide

List of classes of insecticides compiled from the IRAC Mode of Action Classification Scheme (IRAC Interna- tional MoA Working Group, 2017). Individual pesticide names extracted from the same publication, sup- plemented with the WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classifica- tion 2009 (World Health Organization, 2010) and (for the classes of carbamates, neonicotinoids, pyre- throids and organophosphates) Embase Emtree.

If additional compounds belonging to the above-mentioned classes of insecticides are identified during the review process, we may include them as well.

Page 2 of 2 Online appendix B: Search terms for NCBI PubMed

1

"diabetes mellitus"[MeSH Terms] OR "diabetes"[All fields] OR diabet*[All fields] OR iddm[All fields] OR niddm[All fields] OR "hyperglycemia"[MeSH Terms] OR "blood glucose"[MeSH Terms] OR "Glycated Hemoglobin A"[MeSH Terms] OR hyper-glycemi*[All fields] OR hyper-glycaemi*[All fields] OR hyperglycemi*[All fields] OR hyperglycaemi*[All fields] OR hyperglycosemi*[All fields] OR hyperglycosaemi*[All fields] OR "blood glucose"[All fields] OR "blood sugar"[All fields] OR "plasma glucose"[All fields] OR "plasma sugar"[All fields] OR "serum glucose"[All fields] OR "serum sugar"[All fields] OR "glucose homeostasis"[All fields] OR "glucose homeostatic"[All fields] OR "glucose regulation"[All fields] OR dysglycem*[All fields] OR dysglycaem*[All fields] OR glycemi*[All fields] OR glycaemi*[All fields] OR glucosaemi*[All fields] OR glucosemi*[All fields] OR "glycated haemoglobin A1c"[All fields] OR "Glycated Hemoglobin"[All fields] OR "glycated hemoglobin A1c"[All fields] OR "Glycated Hemoglobins"[All fields] OR "Glycohemoglobin A"[All fields] OR "glycosylated haemoglobin A1c"[All fields] OR "Glycosylated Hemoglobin"[All fields] OR "haemoglobin a (1c)"[All fields] OR "haemoglobin a 1c"[All fields] OR "haemoglobin A1c"[All fields] OR "haemoglobin aic"[All fields] OR "hb a (1c)"[All fields] OR "Hb A1"[All fields] OR "Hb A1a+b"[All fields] OR "Hb A1c"[All fields] OR "hba 1c"[All fields] OR "HbA1"[All fields] OR "hba1c"[All fields] OR "hemoglobin a (1c)"[All fields] OR "hemoglobin a 1c"[All fields] OR "Hemoglobin A(1)"[All fields] OR "Hemoglobin A, Glycated"[All fields] OR "Hemoglobin A, Glycosylated"[All fields] OR "Hemoglobin A1c, Glycated"[All fields] OR "Hemoglobin A1c, Glycosylated"[All fields] OR "hemoglobin aic"[All fields] OR "Hemoglobin, Glycosylated"[All fields] OR "Hemoglobins, Glycated"[All fields] OR "prediabetic state"[MeSH Terms] OR prediabet*[All fields] OR pre-diabet*[All fields] OR "impaired fasting glucose"[All fields] OR "glucose intolerance"[MeSH Terms] OR "glucose tolerance test"[MeSH Terms] OR "glucose intolerance"[All fields] OR "glucose intolerant"[All fields] OR "glucose tolerance"[All fields] OR "ogtt"[All fields] OR "glucose load"[All fields] OR "glucose loading test"[All fields] OR "glucose test"[All fields] OR "insulin resistance"[MeSH Terms] OR "Metabolic Syndrome"[Mesh] OR "Hyperinsulinism"[Mesh] OR "insulin resistance"[All fields] OR "insulin resistant"[All fields] OR "insulin sensitivity"[All fields] OR "insulin sensitive"[All fields] OR "insulin insensitivity"[All fields] OR "insulin insensitive"[All fields] OR "metabolic syndrome"[All fields] OR hyperinsuli*[All fields] OR hyper-insuli*[All fields] OR "insulin"[All fields] OR "homeostasis model assessment"[All fields] OR "homeostatic model assessment"[All fields] OR "insulin test"[All fields] OR "Insulin-Secreting Cells"[Mesh] OR hypoinsulin*[All fields] OR hypo-insulin*[All fields] OR "insulinopenia"[All fields] OR "beta cell"[All fields] OR "beta cells"[All fields] OR "beta islet cell"[All fields] OR "insulin producing cell"[All fields] OR "insulin producing cells"[All fields] OR "insulin secreting cell"[All fields] OR "insulin secreting cells"[All fields] OR "pancreas b cell"[All fields] OR "pancreas beta islet cell"[All fields] OR "pancreas islet b cell"[All fields] OR "pancreatic b cell"[All fields] OR "pancreatic islet b cell"[All fields] OR "pancreatic islet b cell"[All fields]

2 "pesticides"[Pharmacological Action] OR "pesticides"[MeSH Terms] OR pesticid*[All Fields] 3 "insecticides"[Pharmacological Action] OR "insecticides"[MeSH Terms] OR insecticid*[All Fields] 4 "carbamates"[MeSH Terms] OR "carbamates"[All Fields] OR "carbamate"[All Fields] 5 "alanicarb"[All Fields] OR "alanycarb"[All Fields] OR "83130-01-2"[EC/RN Number] 6 "aldicarb"[MeSH Terms] OR "aldicarb"[All Fields] OR "temik"[All Fields] OR "temick"[All Fields] OR "116-06-3"[EC/RN Number] 7 "aminocarb"[Supplementary Concept] OR "aminocarb"[All Fields] OR "matacil"[All Fields] OR "4-dimethylamino-3-tolyl-N-methylcarbamate"[All Fields] OR "2032-59-9"[EC/RN Number] 8 "bendiocarb"[Supplementary Concept] OR "bendiocarb"[All Fields] OR "ficam"[All Fields] OR "22781-23-3"[EC/RN Number]

9 "benfuracarb"[Supplementary Concept] OR "benfuracarb"[All Fields] OR "82560-54-1"[EC/RN Number] 10 "butocarboxim"[All Fields] OR "34681-10-2"[EC/RN Number] 11 "butoxycarboxim"[All Fields] OR "34681-23-7"[EC/RN Number] 12 "carbaryl"[MeSH Terms] OR "carbaryl"[All Fields] OR "carbaril"[All Fields] OR "carbyl"[All Fields] OR "63-25-2"[EC/RN Number] OR "27636-33- 5"[EC/RN Number] OR "3197-92-0"[EC/RN Number] 13 "carbofuran"[MeSH Terms] OR "carbofuran"[All Fields] OR "furadan"[All Fields] OR "1563-66-2"[EC/RN Number] 14 "carbosulfan"[Supplementary Concept] OR "carbosulfan"[All Fields] OR "55285-14-8"[EC/RN Number] 15 "croneton"[Supplementary Concept] OR "croneton"[All Fields] OR "ethiofencarb"[All Fields] OR "kroneton"[All Fields] OR "29973-13-5"[EC/RN Number] 16 "BPMC"[Supplementary Concept] OR "BPMC"[All Fields] OR "fenobucarb"[All Fields] OR "3766-81-2"[EC/RN Number] 17 "Fenothiocarb"[All Fields] OR "62850-32-2"[EC/RN Number] 18 "fenoxycarb"[Supplementary Concept] OR "fenoxycarb"[All Fields] OR "ethyl(2-(4-phenoxyphenoxy)ethyl)carbamate"[All Fields] OR "72490-01- 8"[EC/RN Number] 19 "formetanate"[Supplementary Concept] OR "formetanate"[All Fields] OR "22259-30-9"[EC/RN Number] OR "23422-53-9"[EC/RN Number] 20 "deltanit"[Supplementary Concept] OR "deltanit"[All Fields] OR "furathiocarb"[All Fields] OR "furatiocarb"[All Fields] OR "65907-30-4"[EC/RN Number] 21 "isolan"[Supplementary Concept] OR ("isolan"[All Fields]) NOT "Isolan"[Author]) OR "1-isopropyl-3-methyl-5-pyrazolyldimethylcarbamate"[All Fields] OR "dimethylcarbamic acid 1 isopropyl 3 methyl 5 pyrazolyl ester"[All Fields] OR "1 isopropyl 3 methyl 5 pyrazolyl dimethylcarbamate"[All Fields] OR "1 isopropyl 3 methylpyrazol 5 yl dimethylcarbamate"[All Fields] OR "dimethylcarbamic acid 1 isopropyl 3 methylpyrazol 5 yl ester"[All Fields] OR "primin"[All Fields] OR "primine"[All Fields] OR "119-38-0"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

22 "isoprocarb"[Supplementary Concept] OR "isoprocarb"[All Fields] OR "phenyl-2-(1-methylethyl)methylcarbamate"[All Fields] OR "2- isopropylphenyl methylcarbamate"[All Fields] OR "2631-40-5"[EC/RN Number] 23 "methiocarb"[MeSH Terms] OR "methiocarb"[All Fields] OR "mercaptodimethur"[All Fields] OR "2032-65-7"[EC/RN Number] 24 "methomyl"[MeSH Terms] OR "methomyl"[All Fields] OR "lannate"[All Fields] OR "16752-77-5"[EC/RN Number] OR "19928-35-9"[EC/RN Number] OR "19928-37-1"[EC/RN Number] 25 "metolcarb"[Supplementary Concept] OR "metolcarb"[All Fields] OR "1129-41-5"[EC/RN Number] 26 "oxamyl"[Supplementary Concept] OR "oxamyl"[All Fields] OR "vydate"[All Fields] OR "23135-22-0"[EC/RN Number] 27 "pirimicarb"[Supplementary Concept] OR "pirimicarb"[All Fields] OR "pirimor"[All Fields] OR "pyrimor"[All Fields] OR "ZZ-Aphox"[All Fields] OR "23103-98-2"[EC/RN Number] 28 "propoxur"[MeSH Terms] OR "propoxur"[All Fields] OR "O-Isopropoxyphenylmethylcarbamate"[All Fields] OR "O Isopropoxyphenylmethylcarbamate"[All Fields] OR "Unden"[All Fields] OR "sendran"[All Fields] OR "aprocarb"[All Fields] OR "114-26-1"[EC/RN Number] 29 "thiodicarb"[Supplementary Concept] OR "thiodicarb"[All Fields] OR "59669-26-0"[EC/RN Number] 30 "thiofanox"[Supplementary Concept] OR "thiofanox"[All Fields] OR "dacamox"[All Fields] OR "thiofanocarb"[All Fields] OR "39196-18-4"[EC/RN Number] OR "75013-98-8"[EC/RN Number] 31 "triazamate"[Supplementary Concept] OR "triazamate"[All Fields] OR "110895-43-7"[EC/RN Number] OR "112143-82-5"[EC/RN Number] 32 "trimethacarb"[Supplementary Concept] OR "trimethacarb"[All Fields] OR "landrin"[All Fields] OR "landrina"[All Fields] OR "2686-99-9"[EC/RN Number] 33 "xmc"[All Fields] OR "carbaron"[All Fields] OR "3,5-xylyl methylcarbamate"[All Fields] OR "3,5-dimethylphenyl methylcarbamate"[All Fields] OR "cosban"[All Fields] OR "maqbarl"[All Fields] OR "macbal"[All Fields] OR "2655-14-3"[EC/RN Number] 34 "xylylcarb"[All Fields] OR "2425-10-7"[EC/RN Number] 35 "organophosphates"[MeSH Terms] OR "organophosphates"[All Fields] OR "organophosphate"[All Fields] OR "organothiophosphates"[All Fields] OR "organothiophosphate"[All Fields] OR "organophosphorus"[All Fields] OR "organophosphorous"[All Fields] OR "organothiophosphorus"[All Fields] OR "organothiophosphorous"[All Fields] 36 "acephate"[Supplementary Concept] OR "acephate"[All Fields] OR "O,S-dimethyl N-acetyl phosphoramidothioate"[All Fields] OR "orthene"[All Fields] OR "30560-19-1"[EC/RN Number] OR "115096-11-2"[EC/RN Number] 37 "amiton"[Supplementary Concept] OR "amiton"[All Fields] OR "O,O-diethyl S-(diethylaminoethyl) phosphorothiolate"[All Fields] OR "78-53- 5"[EC/RN Number] 38 "azamethiphos"[Supplementary Concept] OR "azamethiphos"[All Fields] OR "35575-96-3"[EC/RN Number] 39 "azinphos ethyl"[Supplementary Concept] OR "azinphos ethyl"[All Fields] OR "azinphos-ethyl"[All Fields] OR "azinphosethyl"[All Fields] OR "ethyl azinphos"[All Fields] OR "ethyl-azinphos"[All Fields] OR "ethylazinphos"[All Fields] OR "2642-71-9"[EC/RN Number] 40 "azinphosmethyl"[MeSH Terms] OR "azinphosmethyl"[All Fields] OR "azinphos-methyl"[All Fields] OR "azinphos methyl"[All Fields] OR "methylazinphos"[All Fields] OR "methyl-azinphos"[All Fields] OR "methyl azinphos"[All Fields] OR "guthion"[All Fields] OR "86-50-0"[EC/RN Number] 41 "cadusafos"[Supplementary Concept] OR "cadusafos"[All Fields] OR "O-ethyl, S-bis(1-methylpropyl)phosphorodithioate"[All Fields] OR "95465- 99-9"[EC/RN Number] 42 "chlorethoxyfos"[All Fields] OR "54593-83-8"[EC/RN Number] OR "3957-63-9"[EC/RN Number] 43 "chlorfenvinphos"[MeSH Terms] OR "chlorfenvinphos"[All Fields] OR "clofenvinfos"[All Fields] OR "chlorphenvinphos"[All Fields] OR "dermaton"[All Fields] OR "birlane"[All Fields] OR "470-90-6"[EC/RN Number] OR "18708-87-7"[EC/RN Number] OR "135373-33-0"[EC/RN Number] 44 "chlormephos"[All Fields] OR "24934-91-6"[EC/RN Number] 45 "chlorpyrifos"[MeSH Terms] OR "chlorpyrifos"[All Fields] OR "lorsban"[All Fields] OR "dursban"[All Fields] OR "2921-88-2"[EC/RN Number] 46 "chlorpyrifos-methyl"[Supplementary Concept] OR "chlorpyrifos-methyl"[All Fields] OR "chlorpyrifos methyl"[All Fields] OR "chlorpyrifosmethyl"[All Fields] OR "methyl-chlorpyrifos"[All Fields] OR "methyl chlorpyrifos"[All Fields] OR "methylchlorpyrifos"[All Fields] OR "dowco 214"[All Fields] OR "reldan"[All Fields] OR "5598-13-0"[EC/RN Number] 47 "coumaphos"[MeSH Terms] OR "coumaphos"[All Fields] OR "asuntol"[All Fields] OR "56-72-4"[EC/RN Number] 48 "crufomate"[Supplementary Concept] OR "crufomate"[All Fields] OR "ruelene"[All Fields] OR "ruerene"[All Fields] OR "299-86-5"[EC/RN Number] 49 "cyanophos"[Supplementary Concept] OR "cyanophos"[All Fields] OR "cyanox"[All Fields] OR "2636-26-2"[EC/RN Number] 50 "cyanophenphos"[Supplementary Concept] OR "cyanophenphos"[All Fields] OR "cyanofenphos"[All Fields] OR "surecide"[All Fields] OR "34460- 46-3"[EC/RN Number] OR "62421-61-8"[EC/RN Number] OR "62421-62-9"[EC/RN Number] OR "13067-93-1"[EC/RN Number] OR "62421-63- 0"[EC/RN Number] 51 "cythioate"[Supplementary Concept] OR "cythioate"[All Fields] OR "cyflee"[All Fields] OR "115-93-5"[EC/RN Number] 52 "demeton-S-methyl"[Supplementary Concept] OR "demeton-S-methyl"[All Fields] OR "demeton s methyl"[All Fields] OR "S-2-ethylthioethyl-O,O- dimethylphosphorothiolate"[All Fields] OR "919-86-8"[EC/RN Number] 53 "diazinon"[MeSH Terms] OR "diazinon"[All Fields] OR "dimpylate"[All Fields] OR "neocidol"[All Fields] OR "neotsidol"[All Fields] OR "bazudine"[All Fields] OR "333-41-5"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

54 "dichlorvos"[MeSH Terms] OR "dichlorvos"[All Fields] OR "ddvp"[All Fields] OR "dichlofos"[All Fields] OR "dimethyl dichlorovinyl phosphate"[All Fields] OR "phosphoric acid 2,2-dichloroethenyl dimethyl ester"[All Fields] OR "phosphoric acid 2,2 dichloroethenyl dimethyl ester"[All Fields] OR "dichlorophos"[All Fields] OR "divipan"[All Fields] OR "novotox"[All Fields] OR "dichlorfos"[All Fields] OR "dichlorofos"[All Fields] OR "dichlorovos"[All Fields] OR "dichlorphos"[All Fields] OR "62-73-7"[EC/RN Number] 55 "dicrotophos"[Supplementary Concept] OR "dicrotophos"[All Fields] OR "carbicron"[All Fields] OR "bidrin"[All Fields] OR "141-66-2"[EC/RN Number] OR "3735-78-2"[EC/RN Number] 56 "dimethoate"[MeSH Terms] OR "dimethoate"[All Fields] OR "phosphamide"[All Fields] OR "rogor"[All Fields] OR "60-51-5"[EC/RN Number] 57 "dimethylvinphos" [Supplementary Concept] OR "dimethylvinphos"[All Fields] OR "2274-67-1"[EC/RN Number] 58 "disulfoton"[MeSH Terms] OR "disulfoton"[All Fields] OR "thiodemeton"[All Fields] OR "di-syston"[All Fields] OR "di syston"[All Fields] OR "disyston"[All Fields] OR "demeton"[All Fields] OR "thiometon ethyl"[All Fields] OR "thiometon-ethyl"[All Fields] OR "thiometonethyl"[All Fields] OR "ethyl thiometon"[All Fields] OR "ethyl-thiometon"[All Fields] OR "ethylthiometon"[All Fields] OR "298-04-4"[EC/RN Number] 59 "Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester"[Mesh] OR "phenylphosphonothioic acid, 2-ethyl 2-(4-nitrophenyl) ester"[All Fields] OR "phenylphosphonothioic acid o ethyl o (4 nitrophenyl) ester"[All Fields] OR "O-Ethyl-O-(4-nitrophenyl)phenylphosphonothioate"[All Fields] OR "benzenephosphonothioic acid o ethyl o 4 nitrophenyl ester"[All Fields] OR "epn"[All Fields] OR "ethyl 4 nitrophenyl phenylphosphonothioate"[All Fields] OR "o (4 nitrophenyl) o ethyl phenylphosphonothioate"[All Fields] OR "o ethyl o (4 nitrophenyl) phenylthiophosphonate"[All Fields] OR "o ethyl o (4 nitrophenyl) phenylphosphonothioate"[All Fields] OR "o ethyl o 4 nitrophenyl benzenephosphonothioate"[All Fields] OR "o ethyl o 4 nitrophenyl benzenethiophosphonate"[All Fields] OR "o ethyl o 4 nitrophenyl phenylphosphonothioate"[All Fields] OR "o ethyl o 4 nitrophenyl phenylphosponothionate"[All Fields] OR "o ethyl o 4 nitrophenylphenylphosphonothioic acid"[All Fields] OR "o ethyl o para nitrophenyl phenylphosphonothioate"[All Fields] OR "o ethyl o para nitrophenyl phenylphosphonothionate"[All Fields] OR "o ethyl o para nitrophenyl phenylthiophosphonate"[All Fields] OR "phenylphosphonethioic acid o ethyl o para nitrophenyl ester"[All Fields] OR "phenylphosphonothioic acid ethyl 4 nitrophenyl ester"[All Fields] OR "phenylphosphonothioic acid o ethyl o 4 nitrophenyl ester"[All Fields] OR "phenylphosphonothioic acid o ethyl o para nitrophenyl ester"[All Fields] OR "phenylphosphonothioic acid, 2 ethyl 2 (4 nitrophenyl) ester"[All Fields] OR "phenylphosphonothioic acid, 2-ethyl 2- (4-nitrophenyl) ester"[All Fields] OR "phenylphosphonothioic acid, o-ethyl o- (4-nitrophenyl) ester"[All Fields]) NOT "emphysematous pyelonephritis"[All Fields] OR "2104-64-5"[EC/RN Number]

60 "ethion"[Supplementary Concept] OR "ethion"[All Fields] OR "diethion"[All Fields] OR "ethopaz"[All Fields] OR "nialate"[All Fields] OR "ethyl methylene phosphorodithioate"[All Fields] OR "diethion"[All Fields] OR "563-12-2"[EC/RN Number] 61 "ethoprophos"[Supplementary Concept] OR "ethoprophos"[All Fields] OR "ethoprop"[All Fields] OR "O-ethyl S,S-diprophyl phosphorodithioate"[All Fields] OR "mocap"[All Fields] OR "o ethyl s, s dipropyl phosphorodithioate"[All Fields] OR "o ethyl s, s dipropylphosphorodithioate"[All Fields] OR "phosphorodithioic acid o ethyl s, s dipropyl ester"[All Fields] OR "prophos"[All Fields] OR "13194-48- 4"[EC/RN Number] 62 "etrimfos"[Supplementary Concept] OR "etrimfos"[All Fields] OR "ekamet"[All Fields] OR "o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioic acid o, o dimethyl ester"[All Fields] OR "o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioate"[All Fields] OR "o, o dimethyl o (6 ethoxy 2 ethylpyrimidin 4 yl) phosphorothioate"[All Fields] OR "phosphorothioic acid o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidinyl) ester"[All Fields] OR "38260-54-7"[EC/RN Number] 63 "famophos"[Supplementary Concept] OR "famophos"[All Fields] OR "O,O-dimethyl O-p-(dimethylsulfamoyl)phenylphosphorothioate"[All Fields] OR "famphur"[All Fields] OR "warbex"[All Fields] OR "varbex"[All Fields] OR "52-85-7"[EC/RN Number] 64 "fenamiphos"[Supplementary Concept] OR "fenamiphos"[All Fields] OR "ethyl 4-(methylthio)m-tolyl isopropylphosphoroamidate"[All Fields] OR "phenamiphos"[All Fields] OR "nemacur"[All Fields] OR "22224-92-6"[EC/RN Number] 65 "fenitrothion"[MeSH Terms] OR "fenitrothion"[All Fields] OR "metathion"[All Fields] OR "dolithion"[All Fields] OR "nitrophos"[All Fields] OR "sumithion"[All Fields] OR "sumithione"[All Fields] OR "accothion"[All Fields] OR "agrothion"[All Fields] OR "dimethyl (3 methyl para nitrophenyl) phosphorothioate"[All Fields] OR "fenitrotion"[All Fields] OR "fenthrothion"[All Fields] OR "fentrothion"[All Fields] OR "folithion"[All Fields] OR "nuvanol"[All Fields] OR "o, o dimethyl o (3 methyl 4 nitrophenyl) phosphorothioate"[All Fields] OR "o, o dimethyl o (3 methyl 4 nitrophenyl) thionophosphate"[All Fields] OR "o, o dimethyl o (3 methyl 4 nitrophenyl) thiophosphate"[All Fields] OR "o, o dimethyl o (3 methyl para nitrophenyl) phosphorothioate"[All Fields] OR "o, o dimethyl o (4 nitro 1, 3 tolyl) phosphorothioate"[All Fields] OR "o, o dimethyl o (para nitro meta tolyl) phosphorothioate"[All Fields] OR "o, o dimethyl o para nitro meta tolylphosphorothioate"[All Fields] OR "phenitrothion"[All Fields] OR "122-14-5"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

66 "fensulfothion"[Supplementary Concept] OR "fensulfothion"[All Fields] OR "(4 methylsulfinylphenyl) phosphorothioic acid diethyl ester"[All Fields] OR "dasanit"[All Fields] OR "dansit"[All Fields] OR "diethyl (4 methylsulfinylphenyl) phosphorothioate"[All Fields] OR "o, o diethyl o (4 methylsulfinyl) phosphorothioic acid"[All Fields] OR "o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate"[All Fields] OR "o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate"[All Fields] OR "o, o diethyl o (para methylsulfinylphenyl) phosphorothioate"[All Fields] OR "phosphorothioic acid o, o diethyl o (4 methylsulfinylphenyl) ester"[All Fields] OR "terracur"[All Fields] OR "115-90-2"[EC/RN Number]

67 "fenthion"[MeSH Terms] OR "fenthion"[All Fields] OR "mercaptophos"[All Fields] OR "lebaycid"[All Fields] OR "4 methylmercapto 3 methylphenyl dimethyl thiophosphate"[All Fields] OR "dimethyl (3 methyl para methylthiophenyl) phosphorothioate"[All Fields] OR "dimethyl (4 methylthio) meta tolyl phosphorothioate"[All Fields] OR "entex"[All Fields] OR "fenthione"[All Fields] OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) phosphorothioate"[All Fields] OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate"[All Fields] OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate"[All Fields] OR "o, o dimethyl o (3 methyl para methylthiophenyl) phosphorothioate"[All Fields] OR "o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate"[All Fields] OR "o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate"[All Fields] OR "o, o dimethyl o (4 methylthio 3 methylphenyl) thiophosphate"[All Fields] OR "queletox"[All Fields] OR "spotton"[All Fields] OR "tiguvon"[All Fields] OR "55-38-9"[EC/RN Number]

68 "fonofos"[MeSH Terms] OR "fonofos"[All Fields] OR "dyfonate"[All Fields] OR "dyphonate"[All Fields] OR "ethylphosphonodithioic acid o ethyl s phenyl ester"[All Fields] OR "fonophos"[All Fields] OR "o ethyl s phenyl ethylphosphonodithioate"[All Fields] OR "944-22-9"[EC/RN Number] OR "62680-03-9"[EC/RN Number] OR "62680-03-9"[EC/RN Number] OR "62705-71-9"[EC/RN Number] 69 "formothion"[Supplementary Concept] OR "formothion"[All Fields] OR "anthio"[All Fields] OR "antio"[All Fields] OR "anfix"[All Fields] OR "s (n formyl n methylcarbamoylmethyl) o, o dimethyl phosphorodithioate"[All Fields] OR "2540-82-1"[EC/RN Number] 70 "fosthiazate"[Supplementary Concept] OR "fosthiazate"[All Fields] OR "(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate"[All Fields] OR "98886-44-3"[EC/RN Number] 71 "heptenophos"[Supplementary Concept] OR "heptenophos"[All Fields] OR "hostaquick"[All Fields] OR "ragadan"[All Fields] OR "23560-59- 0"[EC/RN Number] 72 "imicyafos"[All Fields] OR "140163-89-9"[EC/RN Number] 73 "isofenphos" [Supplementary Concept] OR "isofenphos"[All Fields] OR "isophenphos"[All Fields] OR "isopropylphosphoramidothioic acid o ethyl o 2 isopropoxycarbonylphenyl ester"[All Fields] OR "o ethyl o 2 isopropoxycarbonylphenyl isopropylphosphoramidothioate"[All Fields] OR "oftanol"[All Fields] OR "25311-71-1"[EC/RN Number] OR "103982-07-6"[EC/RN Number] OR "103982-06-5"[EC/RN Number] 74 "isocarbophos"[Supplementary Concept] OR "isocarbophos"[All Fields] OR "O-2-isopropoxycarbonylphenyl O-methyl phosphoramidothioate"[All Fields] OR "24353-61-5"[EC/RN Number] 75 "isoxathion"[All Fields] OR "18854-01-8"[EC/RN Number] 76 "leptophos"[MeSH Terms] OR "leptophos"[All Fields] OR "phosvel"[All Fields] OR "o (2, 5 dichloro 4 bromophenyl) o methylphenylthiophosphonate"[All Fields] OR "phenylphosphonothioic acid o (4 bromo 2, 5 dichlorophenyl) o methyl ester"[All Fields] OR "21609-90-5"[EC/RN Number] OR "73307-67-2"[EC/RN Number] OR "73307-66-1"[EC/RN Number] 77 "malaoxon"[Supplementary Concept] OR "malaoxon"[All Fields] OR "malathion oxon"[All Fields] OR "1634-78-2"[EC/RN Number] 78 "malathion"[MeSH Terms] OR "karbofos"[All Fields] OR "carbophos"[All Fields] OR "carbafos"[All Fields] OR "carbofos"[All Fields] OR "prioderm"[All Fields] OR "sadophos"[All Fields] OR "cythion"[All Fields] OR "derbac m"[All Fields] OR "fosfotion"[All Fields] OR "fyfanon"[All Fields] OR "kypfos"[All Fields] OR "lusap"[All Fields] OR "malathione"[All Fields] OR "malathon"[All Fields] OR "malthion"[All Fields] OR "malthione"[All Fields] OR "nalathion"[All Fields] OR "o, o dimethyl dithiophosphate of diethyl mercaptosuccinate"[All Fields] OR "o, o dimethyldithiophosphate derivative of diethyl succinate"[All Fields] OR "organoderm"[All Fields] OR "ovide"[All Fields] OR "phosphothion"[All Fields] OR "prioderm"[All Fields] OR "(1, 2 dicarbethoxyethyl) o, o dimethyl phosphorodithioate"[All Fields] OR "s (1, 2 dicarbethoxyethyl) o, o dimethyldithiophosphate"[All Fields] OR "sadofos"[All Fields] OR "zithiol"[All Fields] OR "maldison"[All Fields] OR "mercaptothion"[All Fields] OR "121-75-5"[EC/RN Number]

79 "mecarbam"[Supplementary Concept] OR "mecarbam"[All Fields] OR "S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl)-O,O- diethylphosphorodithioate"[All Fields] OR "Murfatox"[All Fields] OR "2595-54-2"[EC/RN Number] 80 "methacrifos"[All Fields] OR "30864-28-9"[EC/RN Number] OR "62610-77-9"[EC/RN Number] 81 "methamidophos"[Supplementary Concept] OR "methamidophos"[All Fields] OR "O,S-dimethylphosphoroamidothioate"[All Fields] OR "metamidophos"[All Fields] OR "tamaron"[All Fields] OR "10265-92-6"[EC/RN Number] OR "65960-97-6"[EC/RN Number] OR "115182-35- 9"[EC/RN Number] 82 "methidathion"[Supplementary Concept] OR "methidathion"[All Fields] OR "metidathion"[All Fields] OR "Supracide"[All Fields] OR "950-37- 8"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

83 "mevinphos"[MeSH Terms] OR "mevinphos"[All Fields] OR "fosdrin"[All Fields] OR "phosdrin"[All Fields] OR "fosdrine"[All Fields] OR "(1 carbomethoxy) 1 propen 2 yl dimethyl phosphate"[All Fields] OR "(2 carbomethoxy 1 methylvinyl) dimethyl phosphate"[All Fields] OR "(carbomethoxypropen 2 yl) dimethyl phosphate"[All Fields] OR "(carbomethoxypropen 2 yl) dimethyl phosphate"[All Fields] OR "(carbomethoxypropen 2 yl) dimethylphosphate"[All Fields] OR "1 carbomethoxy 1 propen 2 yl dimethyl phosphate"[All Fields] OR "1 carbomethoxy 1 propen 2 yl dimethylphosphate"[All Fields] OR "1 carbomethoxy 1 propen 2 yldimethyl phosphate"[All Fields] OR "7786-34- 7"[EC/RN Number] OR "298-01-1"[EC/RN Number] 84 "mipafox"[Supplementary Concept] OR "mipafox"[All Fields] OR "bis (isopropylamino) fluorophosphine oxide"[All Fields] OR "isopestox"[All Fields] OR "371-86-8"[EC/RN Number] 85 "monocrotophos"[MeSH Terms] OR "monocrotophos"[All Fields] OR "nuvacron"[All Fields] OR "azodrin"[All Fields] OR "3 (dimethoxyphosphinoyloxy) n methyl cis crotonamide"[All Fields] OR "3 (dimethoxyphosphinyloxy) n methyl cis crotonamide"[All Fields] OR "3 (dimethoxyphosphinyloxy) n methylcrotonamide"[All Fields] OR "3 [(dimethoxyphosphinoyl) oxy] n methyl cis crotonamide"[All Fields] OR "6923-22-4"[EC/RN Number] OR "2157-98-4"[EC/RN Number] 86 "naled"[MeSH Terms] OR "naled"[All Fields] OR "1, 2 dibromo 2, 2 dichloroethyl dimethyl phosphate"[All Fields] OR "1, 2 dibromo 2, 2 dichloroethyl dimethylphosphate"[All Fields] OR "1, 2 dibromo 2, 2 dichloroethyldimethyl phosphate"[All Fields] OR "alvora"[All Fields] OR "bromex"[All Fields] OR "dibrom"[All Fields] OR "o, o dimethyl o (1, 2 dibromo 2, 2 dichloroethyl) phosphate"[All Fields] OR "phosphoric acid (1, 2 dibromo 2, 2 dichloroethyl) dimethyl ester"[All Fields] OR "phosphoric acid 1, 2 dibromo 2, 2 dichloroethyl dimethyl ester"[All Fields] OR "bromchlophos"[All Fields] OR "300-76-5"[EC/RN Number] 87 "dimethoxon"[Supplementary Concept] OR "dimethoxon"[All Fields] OR "omethoate"[All Fields] OR "o-methoate"[All Fields] OR "folimat"[All Fields] OR "o, o dimethyl s (n methylcarbamoylmethyl) phosphorothioate"[All Fields] OR "phosphorothioic acid o, o dimethyl s (n methylcarbamoylmethyl) ester"[All Fields] OR "1113-02-6"[EC/RN Number] 88 "methyl demeton"[Supplementary Concept] OR "methyl demeton"[All Fields] OR "methyl-demeton"[All Fields] OR "oxydemeton methyl"[All Fields] OR "oxydemeton-methyl"[All Fields] OR "oxydemeton methyl"[All Fields] OR "oxydemeton-methyl"[All Fields] OR "oxydemetonmethyl"[All Fields] OR "methyl oxydemeton"[All Fields] OR "methyl-oxydemeton"[All Fields] OR "methyloxydemeton"[All Fields] OR "demeton-methyl"[All Fields] OR "O,O-dimethyl S-(2-(ethylsulfinyl)ethyl)phosphorothioate"[All Fields] OR "metasystox"[All Fields] OR "methylmercaptophos oxide"[All Fields] OR "301-12-2"[EC/RN Number] 89 "parathion"[MeSH Terms] OR "alkron"[All Fields] OR "aphamite"[All Fields] OR "corthion"[All Fields] OR "diethyl nitrophenyl thiophosphate"[All Fields] OR "diethyl p nitrophenyl monothiophosphate"[All Fields] OR "diethylparathion"[All Fields] OR "dimethyl para nitrophenolthiophosphate"[All Fields] OR "ecatox"[All Fields] OR "ekatox"[All Fields] OR "ethyl parathion"[All Fields] OR "ethylparathion"[All Fields] OR "etilon"[All Fields] OR "folidol"[All Fields] OR "isoparathion"[All Fields] OR "niran"[All Fields] OR "nitrostigmine"[All Fields] OR "o, o diethyl o (4 nitrophenyl) phosphorothioate"[All Fields] OR "o, o diethyl o (4 nitrophenyl) thiophosphate"[All Fields] OR "o, o diethyl o (para nitrophenyl) phosphorothioate"[All Fields] OR "o, o diethyl o p nitrophenyl phosphorothioate"[All Fields] OR "paraphos"[All Fields] OR "parathion"[All Fields] OR "phosphemol"[All Fields] OR "phosphorothioic acid o, o diethyl o (4 nitrophenyl) ester"[All Fields] OR "phosphostigmine"[All Fields] OR "thiophos"[All Fields] OR "tiofos"[All Fields] OR "56-38-2"[EC/RN Number]

90 "methyl parathion"[MeSH Terms] OR "methyl parathion"[All Fields] OR "methyl-parathion"[All Fields] OR "methylparathion"[All Fields] OR "parathion methyl"[All Fields] OR "parathionmethyl"[All Fields] OR "parathion-methyl"[All Fields] OR "demethylfenitrothion"[All Fields] OR "dimethyl para nitrophenyl phosphorothioate"[All Fields] OR "dimethyl para nitrophenylphosphorothioate"[All Fields] OR "dimethyl (para nitrophenyl) phosphorothioate"[All Fields] OR "dimethylnitrophenylthiophosphate"[All Fields] OR "dimethylparathion"[All Fields] OR "fenitrothion, demethyl"[All Fields] OR "metaphos"[All Fields] OR "norfenitrothion"[All Fields] OR "o, o dimethyl o (para nitrophenyl) phosphorothioate"[All Fields] OR "o, o dimethyl o (para nitrophenyl) thiophosphate"[All Fields] OR "o, o dimethyl o (para nitrophenyl) phosphorothioate"[All Fields] OR "o, o dimethyl o (para nitrophenyl) phosphorothionate"[All Fields] OR "o, o dimethyl o para nitrophenyl phosphorothioate"[All Fields] OR "o, o dimethyl para nitrophenyl phosphorothioate"[All Fields] OR "phosphorothioic acid o, o dimethyl o (4 nitrophenyl) ester"[All Fields] OR "vofatox"[All Fields] OR "vophatox"[All Fields] OR "wofatox"[All Fields] OR "dalf"[All Fields] OR "metaphos"[All Fields] OR "298-00-0"[EC/RN Number]

91 "phenthoate"[Supplementary Concept] OR "phenthoate"[All Fields] OR "elsan"[All Fields] OR "phendal"[All Fields] OR "cidial"[All Fields] OR "cidiale"[All Fields] OR "dimethenthoate"[All Fields] OR "fenthoate"[All Fields] OR "phosphorodithioic acid s (alpha carbethoxybenzyl) o, o dimethyl ester"[All Fields] OR "s alpha ethoxycarbonylbenzyl o, o dimethyl phosphorodithioate"[All Fields] OR "tannone"[All Fields] OR "o,o- dimethyl S-alpha-ethoxycarbonylbenzylphosphorodithioate"[All Fields] OR "2597-03-7"[EC/RN Number] OR "61361-99-7"[EC/RN Number] OR "61362-00-3"[EC/RN Number] OR "61391-87-5"[EC/RN Number] 92 "phorate"[MeSH Terms] OR "phorate"[All Fields] OR "diethyl ethylthiomethyl phosphorodithioate"[All Fields] OR "l 11 6"[All Fields] OR "o, o diethyl s (ethylthiomethyl) phosphorodithioate"[All Fields] OR "o, o diethyl s (ethylthiomethyl) phosphorodithioate"[All Fields] OR "phorates"[All Fields] OR "phosphorodithioic acid o, o diethyl s [(ethylthio) methyl] ester"[All Fields] OR "thimet"[All Fields] OR "timet"[All Fields] OR "298-02-2"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

93 "phosalone"[Supplementary Concept] OR "phosalone"[All Fields] OR "phozalone"[All Fields] OR "phoazlone"[All Fields] OR "fozalone"[All Fields] OR "fosalone"[All Fields] OR "fosalon"[All Fields] OR "o, o diethyl s (6 chloro 2 oxobenzoxazolin 3 ylmethyl) phosphorodithioate"[All Fields] OR "s (6 chloro 2 oxobenzoxazolin 3 yl) methyl diethyl phosphorothiolothioate"[All Fields] OR "zolone"[All Fields] OR "benzophosphate"[All Fields] OR "2310-17-0"[EC/RN Number] 94 "phosmet"[MeSH Terms] OR "phosmet"[All Fields] OR "fosmet"[All Fields] OR "imidan"[All Fields] OR "n (mercaptomethyl) phthalimide s (o, o dimethyl) phosphorodithioate"[All Fields] OR "n (mercaptomethyl) phthalimide s (o, o dimethylphosphorodithioate)"[All Fields] OR "o, o dimethyl s (phthalimidomethyl) phosphorodithioate"[All Fields] OR "o, o dimethyl s phthalimidomethyl phosphorodithioate"[All Fields] OR "phosphorodithioic acid o, o dimethyl s phthalimidomethyl ester"[All Fields] OR "porect"[All Fields] OR "phthalophos"[All Fields] OR "732-11- 6"[EC/RN Number] 95 "phosphamidon"[MeSH Terms] OR "phosphamidon"[All Fields] OR "2 chloro n, n diethyl 3 hydroxycrotonamide dimethyl phosphate"[All Fields] OR "dimecron"[All Fields] OR "dimethyl (2 chloro 1 diethylaminocroton 3 yl) phosphate"[All Fields] OR "liromidon"[All Fields] OR "o, o dimethyl o (2 chloro 1 diethylaminocroton 3 yl) phosphate"[All Fields] OR "13171-21-6"[EC/RN Number] OR "23783-98-4"[EC/RN Number] 96 "phoxim"[Supplementary Concept] OR "phoxim"[All Fields] OR "phenylglyoxylonitrile oxime o,o-diethylphosphorothioate"[All Fields] OR "valekson"[All Fields] OR "valexon"[All Fields] OR "sebacil"[All Fields] OR "foxim"[All Fields] OR "o (alpha cyanobenzylideneamino) o, o diethyl phosphorothioate"[All Fields] OR "o, o diethyl o (alpha cyanobenzylideneamino) phosphorothioate"[All Fields] OR "phenylglyoxylonitrile oxime o, o diethylphosphorothioate"[All Fields] OR "volaton"[All Fields] OR "14816-18-3"[EC/RN Number] OR "217075-81-5"[EC/RN Number]

97 "pirimiphos methyl"[Supplementary Concept] OR "pirimiphos methyl"[All Fields] OR "pirimiphosmethyl"[All Fields] OR "pirimiphos-methyl"[All Fields] OR "methyl-pirimiphos"[All Fields] OR "methyl pirimiphos"[All Fields] OR "methylpirimiphos"[All Fields] OR "o-(2-(diethylamino)-6- methyl-4-pyrimidinyl) o,o- dimethylphosphorothioate lic"[All Fields] OR "piritione"[All Fields] OR "actellic"[All Fields] OR "aktel"[All Fields] OR "29232-93-7"[EC/RN Number] 98 "profenofos"[Supplementary Concept] OR "profenofos"[All Fields] OR "curacron"[All Fields] OR "selecron"[All Fields] OR "o (4 bromo 2 chlorophenyl) o ethyl s propyl phosphorothioate"[All Fields] OR "phosphorothioic acid o (4 bromo 2 chlorophenyl) o ethyl s propyl ester"[All Fields] OR "41198-08-7"[EC/RN Number] OR "81123-19-5"[EC/RN Number] OR "81116-98-5"[EC/RN Number] 99 "propetamphos"[Supplementary Concept] OR "propetamphos"[All Fields] OR "31218-83-4"[EC/RN Number] 100 "prothiophos"[Supplementary Concept] OR "prothiophos"[All Fields] OR "prothiofos"[All Fields] OR "tokuthion"[All Fields] OR "tukuthion"[All Fields] OR "34643-46-4"[EC/RN Number] 101 "pyraclofos"[Supplementary Concept] OR "pyraclofos"[All Fields] OR "o-(1-(4-chlorophenyl)-4-pyrazolyl) o-ethyl S-propyl phosphorothioate"[All Fields] OR "77458-01-6"[EC/RN Number] OR "89784-60-1"[EC/RN Number] 102 "pyridafenthion"[Supplementary Concept] OR "pyridafenthion"[All Fields] OR "o,o-diethyl o-(3-oxo-2-phenyl-2H-pyridazin-6- yl) phosphorothioate"[All Fields] OR "pyridaphenthion"[All Fields] OR "ofunack"[All Fields] OR "o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) phosphorothioate"[All Fields] OR "phosphorothioic acid o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) ester"[All Fields] OR "pyridaphenthione"[All Fields] OR "119-12-0"[EC/RN Number] 103 "quinalphos"[Supplementary Concept] OR "quinalphos"[All Fields] OR "diethylquinalphione"[All Fields] OR "o,o-diethyl-o-(quinoxalinyl- (2))thionophosphate"[All Fields] OR "o,o-diethyl-o-(quinoxalyl)phosphorothioate"[All Fields] OR "o, o diethyl o (2 quinoxalinyl) phosphorothioate"[All Fields] OR "phosphorothioic acid o, o diethyl o (2 quinoxalinyl) ester"[All Fields] OR "bayrusil"[All Fields] OR "ekalux"[All Fields] OR "bayer 77049"[All Fields] OR "13593-03-8"[EC/RN Number] 104 "sulfotepp"[Supplementary Concept] OR "sulfotepp"[All Fields] OR "sulfotep"[All Fields] OR "ethyl thiopyrophosphate"[All Fields] OR "asymmetric tetraethyl dithiopyrophosphate"[All Fields] OR "3689-24-5"[EC/RN Number] 105 "tebupirimphos"[All Fields] OR "96182-53-5"[EC/RN Number] 106 "temefos"[MeSH Terms] OR "temefos"[All Fields] OR "temephos"[All Fields] OR "difos"[All Fields] OR "abathion"[All Fields] OR "3383-96- 8"[EC/RN Number] 107 "terbufos"[Supplementary Concept] OR "terbufos"[All Fields] OR "o,o-diethyl s((tert-butylthio)methyl)phosphorodithioate"[All Fields] OR "o, o diethyl s (tert butylthio) methylphosphorodithioate"[All Fields] OR "13071-79-9"[EC/RN Number] 108 "tetrachlorvinphos"[MeSH Terms] OR "tetrachlorvinphos"[All Fields] OR "stirofos"[All Fields] OR "gardona"[All Fields] OR "rabon"[All Fields] OR "2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethylphosphate"[All Fields] OR "2 chloro 1 (2, 4, 5 trichlorophenyl) vinyldimethylphosphate"[All Fields] OR "phosphoric acid 2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethyl ester"[All Fields] OR "stirophos"[All Fields] OR "tetrachlorofenvinphos"[All Fields] OR "961-11-5"[EC/RN Number] OR "22248-79-9"[EC/RN Number] 109 "thiometon"[Supplementary Concept] OR "thiometon"[All Fields] OR "ekatin"[All Fields] OR "intration"[All Fields] OR "aasystem"[All Fields] OR "duphar dimeaat"[All Fields] OR "ecatin"[All Fields] OR "intrathion"[All Fields] OR "intrathione"[All Fields] OR "luxan"[All Fields] OR "o, o dimethyl s (2 ethylthioethyl) phosphorodithioate"[All Fields] OR "o, o dimethyl s (2 ethylthioethyl) phosphorodithioate"[All Fields] OR "o, o dimethyl s ethylthioethyl phosphorodithioate"[All Fields] OR "sysmeton"[All Fields] OR "640-15-3"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

110 "triazophos"[Supplementary Concept] OR "triazophos"[All Fields] OR "1-phenyl-3-(o,o-diethylthiophosphoryl)-1,2,4- triazole"[All Fields] OR "hostathion"[All Fields] OR "o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) phosphorothioate"[All Fields] OR "phosphorothioic acid o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) ester"[All Fields] OR "24017-47-8"[EC/RN Number] 111 "merphos"[Supplementary Concept] OR "merphos"[All Fields] OR "tributyl phosphorotrithioite"[All Fields] OR "s,s,s-tributyl phosphorotrithioite"[All Fields] OR "folex"[All Fields] OR "tributyl-phosphorotrithioite"[All Fields] OR "tributylphosphorotrithioite"[All Fields] OR "phosphorotrithioite tributyl"[All Fields] OR "phosphorotrithioite-tributyl"[All Fields] OR "phosphorotrithioitetributyl"[All Fields] OR "150-50- 5"[EC/RN Number] 112 "trichlorfon"[MeSH Terms] OR "chlorophos"[All Fields] OR "chlorofos"[All Fields] OR "metrifonate"[All Fields] OR "dipterex"[All Fields] OR "dylox"[All Fields] OR "neguvon"[All Fields] OR "ricifon"[All Fields] OR "bilarcil"[All Fields] OR "bilacil"[All Fields] OR "bilharcil"[All Fields] OR "foschlor"[All Fields] OR "2, 2, 2 trichloro 1 hydroxyethylphosphonic acid dimethyl ester"[All Fields] OR "bay a 9826"[All Fields] OR "bay a9826"[All Fields] OR "bayer 15922"[All Fields] OR "bayer 2349"[All Fields] OR "bayer l 13-59"[All Fields] OR "bayer l 1359"[All Fields] OR "bayer l13-59"[All Fields] OR "bayer l1359"[All Fields] OR "combot"[All Fields] OR "dimethyl (2, 2, 2 trichloro 1 hydroxyethyl) phosphonate"[All Fields] OR "dyrex"[All Fields] OR "dyvon"[All Fields] OR "etfoschlor"[All Fields] OR "flibol e"[All Fields] OR "masoten"[All Fields] OR "metriphonate"[All Fields] OR "metrifonate"[All Fields] OR "metrofinate"[All Fields] OR "o, o dimethyl 1 hydroxy 2, 2, 2 trichloroethylphosphonate"[All Fields] OR "o, o dimethyl 2, 2, 2 trichloro 1 hydroxyethylphosphonate"[All Fields] OR "o, o dimethyl (1 hydroxy 2, 2, 2 trichlorethyl) phosphonate"[All Fields] OR "promem"[All Fields] OR "promen"[All Fields] OR "trichlorfon"[All Fields] OR "trichlorofon"[All Fields] OR "trichlorophon"[All Fields] OR "trichlorophone"[All Fields] OR "trichlorphon"[All Fields] OR "trichlorphone"[All Fields] OR "tugon"[All Fields] OR "dipterex"[All Fields] OR "52-68-6"[EC/RN Number] OR "56042-26-3"[EC/RN Number] OR "56042-27-4"[EC/RN Number]

113 "vamidothion"[Supplementary Concept] OR "o,o-dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl)phosphorothioate"[All Fields] OR "kilval"[All Fields] OR "vamidothion"[All Fields] OR "2275-23-2"[EC/RN Number] 114 "fiproles"[All Fields] OR "fiprole"[All Fields] 115 "ethiprole"[Supplementary Concept] OR "ethiprole"[All Fields] OR "181587-01-9"[EC/RN Number] 116 "fipronil"[Supplementary Concept] OR "fipronil"[All Fields] OR "fiprex"[All Fields] OR "120068-37-3"[EC/RN Number] 117 "pyrethrins"[MeSH Terms] OR "pyrethrin"[All Fields] OR "pyrethrins"[All Fields] OR "pyrethroid"[All Fields] OR "pyrethroids"[All Fields] OR "ipevet"[All Fields] OR "ipevetex"[All Fields] OR "pyrethrasin"[All Fields] 118 "acrinathrin"[Supplementary Concept] OR "acrinathrin"[All Fields] OR "101007-06-1"[EC/RN Number] 119 "allethrin"[MeSH Terms] OR "allethrin"[All Fields] OR "allethrins"[All Fields] OR "3 allyl 2 methyl 4 oxo 2 cyclopenten 1 yl chrysanthemate"[All Fields] OR "3 allyl 2 methyl 4 oxo 2 cyclopentenyl chrysanthemate"[All Fields] OR "allethrine"[All Fields] OR "allyl cinerin"[All Fields] OR "allethroxyl d, l cis, trans chrysanthemate"[All Fields] OR "pynamin"[All Fields] OR "pyresyn"[All Fields] OR "28434-00-6"[EC/RN Number] OR "584-79-2"[EC/RN Number] OR "34624-48-1"[EC/RN Number] OR "42534-61-2 3972-20-1"[EC/RN Number] OR "84030-86-4"[EC/RN Number] 120 "bifenthrin"[Supplementary Concept] OR "bifenthrin"[All Fields] OR "bifenthrine"[All Fields] OR "fmc 54800"[All Fields] OR "fmc54800"[All Fields] OR "talstar"[All Fields] OR "82657-04-3"[EC/RN Number] OR "439680-76-9"[EC/RN Number] 121 "bioallethrin"[Supplementary Concept] OR "bioallethrin"[All Fields] OR "allethrin, bio"[All Fields] OR "s-bioallethrin"[All Fields] OR "d-trans- allethrin"[All Fields] 122 "bioresmethrin"[Supplementary Concept] OR "bioresmethrin"[All Fields] OR "trans-resmethrin"[All Fields] OR "ru 11484"[All Fields] OR "d-trans- resmethrin"[All Fields] OR "28434-01-7"[EC/RN Number] OR "10453-55-1"[EC/RN Number] 123 "cismethrin"[Supplementary Concept] OR "cismethrin"[All Fields] OR "5-benzyl-3-furylmethyl(1.R)-cis-chrysanthemate"[All Fields] OR "NRDC 119"[All Fields] OR "cis (+) resmethrin"[All Fields] OR "methrin, cis"[All Fields] OR "resmethrin, cis (+)"[All Fields] OR "35764-59-1"[EC/RN Number] 124 "cycloprothrin"[Supplementary Concept] OR "cycloprothrin"[All Fields] OR "63935-38-6"[EC/RN Number] 125 "cyfluthrin"[Supplementary Concept] OR "cyfluthrin"[All Fields] OR "oms 2012"[All Fields] OR "oms-2012"[All Fields] OR "beta-cyfluthrin"[All Fields] OR "beta cyfluthrin"[All Fields] OR "bay fcr 1272"[All Fields] OR "bay fcr1272"[All Fields] OR "baythroid"[All Fields] OR "baytroid"[All Fields] OR "ciflutrin"[All Fields] OR "cyfloxylate"[All Fields] OR "fcr 1272"[All Fields] OR "fcr1272"[All Fields] OR "68359-37-5"[EC/RN Number] 126 "cyhalothrin"[Supplementary Concept] OR "cyhalothrin"[All Fields] OR "lambda-cyhalothrin"[All Fields] OR "lambdacyhalothrin"[All Fields] OR "pp 321"[All Fields] OR "oms 3021"[All Fields] OR "oms-3021"[All Fields] OR "gamma cyhalothrin"[All Fields] OR "gamma-cyhalothrin"[All Fields] OR "gammacyhalothrin"[All Fields] OR "68085-85-8"[EC/RN Number] OR "91465-08-6"[EC/RN Number] OR "76703-62-3"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

127

"cypermethrin"[Supplementary Concept] OR "cypermethrin"[All Fields] OR "2 (2, 2 dichlorovinyl) 3, 3 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester"[All Fields] OR "3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester"[All Fields] OR "3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid meta phenoxymandelonitrile ester"[All Fields] OR "alfa cypermethrin"[All Fields] OR "alfa methrin"[All Fields] OR "alfa methrine"[All Fields] OR "alfacypermethrin"[All Fields] OR "alfamethrin"[All Fields] OR "alfamethrine"[All Fields] OR "alpha cyano 3 phenoxybenzyl 3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylate"[All Fields] OR "alpha cypermethrin"[All Fields] OR "alpha cypermethrine"[All Fields] OR "alpha-cypermethrin"[All Fields] OR "alphacypermethrin"[All Fields] OR "alpha methrin"[All Fields] OR "alpha methrine"[All Fields] OR "alphacypermethrin"[All Fields] OR "alphamethrin"[All Fields] OR "alphamethrine"[All Fields] OR "barricade"[All Fields] OR "beta cypermethrine"[All Fields] OR "beta cypermethrin"[All Fields] OR "beta- cypermethrin"[All Fields] OR "betacypermethrin"[All Fields] OR "ccn 52"[All Fields] OR "ccn52"[All Fields] OR "cipermethrin"[All Fields] OR "cis cypermethrin"[All Fields] OR "cypermethrine"[All Fields] OR "cypermetrin"[All Fields] OR "flectron"[All Fields] OR "fmc 30980"[All Fields] OR "fmc30980"[All Fields] OR "nrdc 149"[All Fields] OR "nrdc 182"[All Fields] OR "nrdc149"[All Fields] OR "nrdc182"[All Fields] OR "wl 43467"[All Fields] OR "wl 85871"[All Fields] OR "wl43467"[All Fields] OR "wl85871"[All Fields] OR "supermethrin"[All Fields] OR "supercypermethrin"[All Fields] OR "cymbush"[All Fields] OR "fastac 50EC"[All Fields] OR "fendona"[All Fields] OR "beta-cipermetrina"[All Fields] OR "theta cypermethrin"[All Fields] OR "theta-cypermethrin"[All Fields] OR "thetacypermethrin"[All Fields] OR "zeta cypermethrin"[All Fields] OR "zeta- cypermethrin"[All Fields] OR "zetacypermethrin"[All Fields] OR "71697-59-1"[EC/RN Number] OR "52315-07-8"[EC/RN Number] OR "67375-30- 8"[EC/RN Number] OR "97955-44-7"[EC/RN Number] OR "72204-44-5"[EC/RN Number] OR "65731-84-2"[EC/RN Number] OR "83860-32- 6"[EC/RN Number] OR "65732-07-2"[EC/RN Number] OR "1315501-18-8"[EC/RN Number]

128 "cyphenothrin"[Supplementary Concept] OR "cyphenothrin"[All Fields] OR "cis-cyphenothrin"[All Fields] OR "alpha cyano 3 phenoxybenzyl chrysanthemate"[All Fields] OR "chrysanthemic acid alpha cyano 3 phenoxybenzyl ester"[All Fields] OR "39515-40-7"[EC/RN Number] 129 "decamethrin"[Supplementary Concept] OR "decamethrin"[All Fields] OR "deltamethrin"[All Fields] OR "butox"[All Fields] OR "oms 1998"[All Fields] OR "difexon"[All Fields] OR "k-othrin"[All Fields] OR "nrdc 161"[All Fields] OR "decis"[All Fields] OR "deltanil"[All Fields] OR "k othrine"[All Fields] OR "pediculosane"[All Fields] OR "52820-00-5"[EC/RN Number] OR "120710-24-9"[EC/RN Number] OR "52918-63-5"[EC/RN Number] OR "120710-25-0"[EC/RN Number] OR "55700-99-7"[EC/RN Number] OR "120710-23-8"[EC/RN Number] OR "80845-12-1"[EC/RN Number] 130 "empenthrin"[Supplementary Concept] OR "empenthrin"[All Fields] OR "1-ethynyl-2-methyl-2-pentenyl chrysanthemate"[All Fields] OR "s 2852f"[All Fields] OR "s-2852f"[All Fields] OR "vaporthrin"[All Fields] OR "d-empenthrin"[All Fields] OR "54406-48-3"[EC/RN Number] 131 "esfenvalerate"[All Fields] OR "66230-04-4"[EC/RN Number] 132 "ethofenprox"[Supplementary Concept] OR "ethofenprox"[All Fields] OR "2-(4-ethoxyphenyl)-2-methylpropyl-3-phenoxybenzyl ether"[All Fields] OR "etofenprox"[All Fields] OR "Trebon"[All Fields] OR "80844-07-1"[EC/RN Number] 133 "fenpropathrin"[Supplementary Concept] OR "fenpropathrin"[All Fields] OR "(alpha cyano 3 phenoxybenzyl) 2, 2, 3, 3 tetramethylcyclopropanecarboxylate"[All Fields] OR "2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid (alpha cyano 3 phenoxybenzyl) ester"[All Fields] OR "2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester"[All Fields] OR "alpha cyano 3 phenoxybenzyl 2, 2, 3, 3 tetramethylcyclopropanecarboxylate"[All Fields] OR "fenpropanate"[All Fields] OR "meothrin"[All Fields] OR "39515-41-8"[EC/RN Number] 134 "fenvalerate"[Supplementary Concept] OR "fenvalarate"[All Fields] OR "(alpha cyano 3 phenoxybenzyl) 2 (4 chlorophenyl) 3 methylbutyrate"[All Fields] OR "2 (4 chlorophenyl) 3 methylbutyric acid (alpha cyano 3 phenoxybenzyl) ester"[All Fields] OR "2 (4 chlorophenyl) isovaleric acid alpha cyano 3 phenoxybenzyl ester"[All Fields] OR "3 phenoxymandelonitrile 2 (4 chlorophenyl) 2 isopropylacetate"[All Fields] OR "alpha cyano 3 phenoxybenzyl alpha isopropyl 4 chlorophenylacetate"[All Fields] OR "alpha isopropyl 4 chlorophenylacetic acid alpha cyano 3 phenoxybenzyl ester"[All Fields] OR "arkofly"[All Fields] OR "belmark"[All Fields] OR "cyano (3 phenoxyphenyl) methyl 4 chloro alpha (1 methylethyl) benzeneacetate"[All Fields] OR "ectrin"[All Fields] OR "phenvalerate"[All Fields] OR "pidrin"[All Fields] OR "pydrin"[All Fields] OR "pyrethroid sd 43775"[All Fields] OR "s 5602"[All Fields] OR "s-5602"[All Fields] OR "sd 43775"[All Fields] OR "sumicidin"[All Fields] OR "wl 43775"[All Fields] OR "sumi-alpha"[All Fields] OR "belmark"[All Fields] OR "alpha-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3- methylbutyrate"[All Fields] OR "alpha-cyano-3-phenoxybenzyl alpha-isopropyl-4-chlorophenyl acetate"[All Fields] OR "51630-58-1"[EC/RN Number] OR "66267-77-4"[EC/RN Number] OR "67614-32-8"[EC/RN Number] OR "67614-33-9"[EC/RN Number]

135 "flucythrinate"[Supplementary Concept] OR "flucythrinate"[All Fields] OR "(alpha cyano 3 phenoxybenzyl) 4 difluoromethoxy alpha isopropylphenylacetate"[All Fields] OR "4 difluoromethoxy alpha isopropylphenylacetic acid alpha cyano 3 phenoxybenzyl ester"[All Fields] OR "ac 222, 705"[All Fields] OR "ac 222705"[All Fields] OR "ac222, 705"[All Fields] OR "ac222705"[All Fields] OR "cyano (3 phenoxyphenyl) methyl 4 (difluoromethoxy) alpha (1 methylethyl) benzeneacetate"[All Fields] OR "70124-77-5"[EC/RN Number] 136 "flumethrin"[Supplementary Concept] OR "flumethrin"[All Fields] OR "bayticol"[All Fields] OR "69770-45-2"[EC/RN Number] 137 "fluvalinate"[Supplementary Concept] OR "fluvalinate"[All Fields] OR "tau-fluvalinate"[All Fields] OR "tau fluvalinate"[All Fields] OR "taufluvalinate"[All Fields] OR "mavrik"[All Fields] OR "69409-94-5"[EC/RN Number] OR "102851-06-9"[EC/RN Number] 138 "halfenprox"[Supplementary Concept] OR "halfenprox"[All Fields] OR "brofenprox"[All Fields] OR "111872-58-3"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

139 "imiprothrin"[All Fields] OR "72963-72-5"[EC/RN Number] OR "173240-50-1"[EC/RN Number] OR "70062-52-1"[EC/RN Number] 140 "kadethrin"[Supplementary Concept] OR "kadethrin"[All Fields] OR "58769-20-3"[EC/RN Number] 141 "permethrin"[MeSH Terms] OR "permethrin"[All Fields] OR "cis-permethrin"[All Fields] OR "cis permethrin"[All Fields] OR "cispermethrin"[All Fields] OR "cis-(1rs)-permethrin"[All Fields] OR "trans-permethrin"[All Fields] OR "trans permethrin"[All Fields] OR "transpermethrin"[All Fields] OR "trans-(1rs)-permethrin"[All Fields] OR "pp-557"[All Fields] OR "pp 557"[All Fields] OR "pp557"[All Fields] OR "s-3151"[All Fields] OR "s 3151"[All Fields] OR "s3151"[All Fields] OR "elimite"[All Fields] OR "fmc-33297"[All Fields] OR "fmc 33297"[All Fields] OR "fmc33297"[All Fields] OR "nia-33297"[All Fields] OR "nia 33297"[All Fields] OR "nia33297"[All Fields] OR "nittifor"[All Fields] OR "nrdc-143"[All Fields] OR "nrdc 143"[All Fields] OR "nrdc143"[All Fields] OR "nrdc-147"[All Fields] OR "nrdc 147"[All Fields] OR "nrdc147"[All Fields] OR "acticin"[All Fields] OR "armol"[All Fields] OR "atroban"[All Fields] OR "dronol"[All Fields] OR "ectiban"[All Fields] OR "ectomethrin"[All Fields] OR "expar"[All Fields] OR "gamabenceno plus"[All Fields] OR "gamaderm"[All Fields] OR "infectopedicul"[All Fields] OR "klinits"[All Fields] OR "loxazol"[All Fields] OR "lyclear"[All Fields] OR "mite-x"[All Fields] OR "nedax plus"[All Fields] OR "new-nok"[All Fields] OR "novo-herklin 2000"[All Fields] OR "oms 1821"[All Fields] OR "perigen"[All Fields] OR "permanone"[All Fields] OR "permectrin"[All Fields] OR "permicren"[All Fields] OR "permite"[All Fields] OR "piopel"[All Fields] OR "quellada-p"[All Fields] OR "scabmite"[All Fields] OR "stockade"[All Fields] OR "stockate"[All Fields] OR "wl 43479"[All Fields] OR "zehu-ze"[All Fields] OR "52645-53-1"[EC/RN Number] OR "52341-32-9"[EC/RN Number] OR "52341-33-0"[EC/RN Number] OR "61949-76-6"[EC/RN Number]

142 "phenothrin"[Supplementary Concept] OR "d-phenothrin"[All Fields] OR "phenothrin"[All Fields] OR "sumithrin"[All Fields] OR "s-2539"[All Fields] OR "3 phenoxybenzyl chrysanthemate"[All Fields] OR "chrysanthemic acid 3 phenoxybenzyl ester"[All Fields] OR "fenothrin"[All Fields] OR "sumithrin"[All Fields] OR "26002-80-2"[EC/RN Number] 143 "d, d-T80-prallethrin"[Supplementary Concept] OR "2-methyl-4-oxo-3-(2-propynyl)cyclopent-2-enyl chrysanthemate"[All Fields] OR "prallethrin"[All Fields] OR "d,d-t80-prallethrin"[All Fields] OR "23031-36-9"[EC/RN Number] OR "103065-19-6"[EC/RN Number] 144 "pyrethrum"[All Fields] OR "pyrethrums"[All Fields] OR "cinerin"[All Fields] OR "cinerins"[All Fields] OR "jasmolin"[All Fields] OR "jasmolins"[All Fields] OR "8003-34-7"[EC/RN Number] 145 "resmethrin"[Supplementary Concept] OR "resmethrin"[All Fields] OR "chryson"[All Fields] OR "sbp 1382"[All Fields] OR "scourge"[All Fields] OR "10453-86-8"[EC/RN Number] 146 "silafluofen"[Supplementary Concept] OR "silafluofen"[All Fields] OR "salifluofen"[All Fields] OR "105024-66-6"[EC/RN Number] 147 "2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate"[Supplementary Concept] OR "tefluthrin"[All Fields] OR "79538-32-2"[EC/RN Number] 148 "tetramethrin"[Supplementary Concept] OR "tetramethrin"[All Fields] OR "3, 4, 5, 6 tetrahydrophthalimidomethyl chrysanthemate"[All Fields] OR "chrysanthemic acid 3, 4, 5, 6 tetrahydrophthalimidomethyl ester"[All Fields] OR "lenpoucid"[All Fields] OR "neopynamin"[All Fields] OR "neopynamine"[All Fields] OR "phthalthrin"[All Fields] OR "sanpouxil"[All Fields] OR "7696-12-0"[EC/RN Number] OR "66525-27-7"[EC/RN Number] OR "5284-41-3"[EC/RN Number] OR "52556-74-8"[EC/RN Number] OR "1166-46-7"[EC/RN Number] OR "51348-91-5"[EC/RN Number] OR "51348-90-4"[EC/RN Number] 149 "tralomethrin"[Supplementary Concept] OR "tralomethrin"[All Fields] OR "66841-25-6"[EC/RN Number] OR "1375081-91-6"[EC/RN Number] 150 "transfluthrin"[Supplementary Concept] OR "transfluthrin"[All Fields] OR "118712-89-3"[EC/RN Number] 151 "neonicotinoids"[MeSH Terms] OR "neonicotinoids"[All Fields] OR "neonicotinoid"[All Fields] 152 "acetamiprid"[Supplementary Concept] OR "acetamiprid"[All Fields] OR "td-2480"[All Fields] OR "td-2472"[All Fields] OR "160430-64-8"[EC/RN Number] OR "135410-20-7"[EC/RN Number] 153 "clothianidin"[Supplementary Concept] OR "clothianidin"[All Fields] OR "((e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine)"[All Fields] OR "ti-435"[All Fields] OR "ti 435"[All Fields] OR "1 (2 chloro 1, 3 thiazol 5 ylmethyl) 3 methyl 2 nitroguanidine"[All Fields] OR "1 (2 chloro 5 thiazolylmethyl) 3 methyl 2 nitroguanidine"[All Fields] OR "clothianidine"[All Fields] OR "210880-92-5"[EC/RN Number] 154 "dinotefuran"[Supplementary Concept] OR "dinotefuran"[All Fields] OR "1-methyl-2-nitro-3-((3-tetrahydrofuryl)methyl)guanidine"[All Fields] OR "mti-446"[All Fields] OR "mti 446"[All Fields] OR "2 methyl 1 nitro 3 (tetrahydrofurfuryl) guanidine"[All Fields] OR "165252-70-0"[EC/RN Number] 155 "imidacloprid"[Supplementary Concept] OR "imidacloprid"[All Fields] OR "1 (6 chloro 3 pyridylmethyl) n nitroimidazolidin 2 ylideneamine"[All Fields] OR "1-((6-chloro-3-pyridinyl)methyl)-n-nitro-2-imidazolidinimine"[All Fields] OR "premise 75"[All Fields] OR "138261-41-3"[EC/RN Number] OR "105827-78-9"[EC/RN Number] 156 "nitenpyram"[Supplementary Concept] OR "nitenpyram"[All Fields] OR "capstar"[All Fields] OR "120738-89-8"[EC/RN Number] OR "150824-47- 8"[EC/RN Number] 157 "nithiazine"[Supplementary Concept] OR "nithiazine"[All Fields] OR "tetrahydro-2-(nitromethylene)-2h-1,3-thiazine"[All Fields] OR "ski-71"[All Fields] OR "wl-35651"[All Fields] OR "ls-192830"[All Fields] OR "sd 35651"[All Fields] OR "sd-35651"[All Fields] OR "tetrahydro 2 nitromethylene 2h 1, 3 thiazine"[All Fields] OR "58842-20-9"[EC/RN Number] OR "97190-65-3"[EC/RN Number] 158 "thiacloprid"[Supplementary Concept] OR "thiacloprid"[All Fields] OR "thiaclopride"[All Fields] OR "3-((6-chloro-3-pyridinyl)methyl)-2- thiazolidinylidene cyanamide"[All Fields] OR "111988-49-9"[EC/RN Number] Online appendix B: Search terms for NCBI PubMed

159 "thiamethoxam"[Supplementary Concept] OR "thiamethoxam"[All Fields] OR "actara 25 WG"[All Fields] OR "cga 293343"[All Fields] OR "cga- 293343"[All Fields] OR "153719-23-4"[EC/RN Number] 160 "sulfoxaflor"[Supplementary Concept] OR "sulfoxaflor"[All Fields] OR "946578-00-3"[EC/RN Number] 161 "flupyradifurone"[Supplementary Concept] OR "flupyradifurone"[All Fields] OR "4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan- 2(5h)-one"[All Fields] OR "sivanto"[All Fields] OR "951659-40-8"[EC/RN Number] 162 "triflumezopyrim"[Supplementary Concept] OR "triflumezopyrim"[All Fields] OR "1263133-33-0"[EC/RN Number] 163 "spinosyn J" [Supplementary Concept] OR "spinosyn H" [Supplementary Concept] OR "spinosyn K" [Supplementary Concept] OR "spinosyn D" [Supplementary Concept] OR "spinosyn A" [Supplementary Concept] OR "Natular T30" [Supplementary Concept] OR "spinosyn G" [Supplementary Concept] OR "2'-desmethoxy spinosyn D" [Supplementary Concept] OR "3'-desmethoxy spinosyn D" [Supplementary Concept] OR "spinosyn"[All Fields] OR "spinosyns"[All Fields] OR "a 83543a"[All Fields] OR "a83543a"[All Fields] OR "lepicidin A"[All Fields] 164 "spinetoram"[Supplementary Concept] OR "spinetoram"[All Fields] OR "xde-175"[All Fields] OR "187166-15-0"[EC/RN Number] OR "187166-40- 1"[EC/RN Number] 165 "spinosad"[Supplementary Concept] OR "spinosad"[All Fields] OR "ly 232105"[All Fields] OR "ly232105"[All Fields] OR "natroba"[All Fields] OR "131929-63-0"[EC/RN Number] OR "131929-60-7"[EC/RN Number] 166 "avermectin" [Supplementary Concept] OR "milbemycin"[Supplementary Concept] OR "avermectin"[All Fields] OR "avermectins"[All Fields] OR "aversectin"[All Fields] OR "aversectins"[All Fields] OR "milbemycin"[All Fields] OR "milbemycins"[All Fields] OR "5-o-demethylavermectin a1a"[All Fields] OR "22, 23 dihydroavermectin b1"[All Fields] OR "milbemax"[All Fields] OR "moxidectin"[All Fields] 167 "abamectin"[Supplementary Concept] OR "abamectin"[All Fields] OR "vertimec"[All Fields] OR "avermectin B1"[All Fields] OR "enzec"[All Fields] OR "65195-55-3"[EC/RN Number] OR "65195-56-4"[EC/RN Number] 168 "emamectin benzoate"[Supplementary Concept] OR "emamectin benzoate"[All Fields] OR "155569-91-8"[EC/RN Number] OR "138511-98- 5"[EC/RN Number] OR "138511-97-4"[EC/RN Number] OR "155569-91-8"[EC/RN Number] 169 "lepimectin A3" [Supplementary Concept] OR "lepimectin A4" [Supplementary Concept] OR "lepimectin"[All Fields] OR "1016160-53-4"[EC/RN Number] 170 "milbemectin"[All Fields] OR "171249-05-1"[EC/RN Number] OR "950999-51-6"[EC/RN Number] 171 "pymetrozine"[Supplementary Concept] OR "pymetrozine"[All Fields] OR "123312-89-0"[EC/RN Number] 172 "1,1,3,4-tetrahydro-6-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)quinazolin-2,4-dione"[Supplementary Concept] OR "pyrifluquinazon"[All Fields] OR "337458-27-2"[EC/RN Number] 173 "flonicamid"[Supplementary Concept] OR "flonicamid"[All Fields] OR "n-cyanomethyl-4-trifluoromethylnicotinamide"[All Fields] OR "carbine"[All Fields] OR "158062-67-0"[EC/RN Number] 174 "bensultap"[Supplementary Concept] OR "bensultap"[All Fields] OR "bancol"[All Fields] OR "17606-31-4"[EC/RN Number] 175 "carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester" [Supplementary Concept] OR "cartap"[All Fields] OR "padan"[All Fields] OR "15263-53-3"[EC/RN Number] OR "15263-52-2"[EC/RN Number] 176 "N, N-dimethyl-1,2,3-trithian-5-yl amine"[Supplementary Concept] OR "n, n-dimethyl-1,2,3-trithian-5-yl amine"[All Fields] OR "thiocyclam"[All Fields] OR "31895-21-3"[EC/RN Number] 177 "S, S'-(2-(dimethylamino)trimethylene)di(thiosulfate)"[Supplementary Concept] OR "thiosultap"[All Fields] OR "thosultap"[All Fields] OR "molosultap"[All Fields] OR "monomehypo"[All Fields] OR "monosultap"[All Fields] OR "bisultap"[All Fields] OR "dimehypo"[All Fields] OR "disosultap"[All Fields] OR "52207-48-4"[EC/RN Number] 178 "amitraz"[Supplementary Concept] OR "amitraz"[All Fields] OR "mitaban"[All Fields] OR "taktic"[All Fields] OR "n-methyl-bis(2,4- xylyiminomethyl) amine"[All Fields] OR "u 36059"[All Fields] OR "33089-61-1"[EC/RN Number] 179 "indoxacarb"[Supplementary Concept] OR "indoxacarb"[All Fields] OR "activyl"[All Fields] OR "dpx-mp062"[All Fields] OR "dpx mp 062"[All Fields] OR "dpx mp062"[All Fields] OR "dpxmp 062"[All Fields] OR "dpxmp062"[All Fields] OR "173584-44-6"[EC/RN Number] 180 "metaflumizone"[Supplementary Concept] OR "metaflumizone"[All Fields] OR "139968-49-3"[EC/RN Number] OR "139970-56-2"[EC/RN Number] 181 "chlorantranilipole"[Supplementary Concept] OR "chlorantranilipole"[All Fields] OR "chlorantraniliprole"[All Fields] OR "dpx-e2y45"[All Fields] OR "rynaxypyr"[All Fields] OR "500008-45-7"[EC/RN Number] 182 "cyantraniliprole"[Supplementary Concept] OR "cyantraniliprole"[All Fields] OR "736994-63-1"[EC/RN Number] 183 "flubendiamide"[Supplementary Concept] OR "flubendiamide"[All Fields] OR "272451-65-7"[EC/RN Number] 184 1 AND (2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31 OR 32 OR 33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 OR 45 OR 46 OR 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56 OR 57 OR 58 OR 59 OR 60 OR 61 OR 62 OR 63 OR 64 OR 65 OR 66 OR 67 OR 68 OR 69 OR 70 OR 71 OR 72 OR 73 OR 74 OR 75 OR 76 OR 77 OR 78 OR 79 OR 80 OR 81 OR 82 OR 83 OR 84 OR 85 OR 86 OR 87 OR 88 OR 89 OR 90 OR 91 OR 92 OR 93 OR 94 OR 95 OR 96 OR 97 OR 98 OR 99 OR 100 OR 101 OR 102 OR 103 OR 104 OR 105 OR 106 OR 107 OR 108 OR 109 OR 110 OR 111 OR 112 OR 113 OR 114 OR 115 OR 116 OR 117 OR 118 OR 119 OR 120 OR 121 OR 122 OR 123 OR 124 OR 125 OR 126 OR 127 OR 128 OR 129 OR 130 OR 131 OR 132 OR 133 OR 134 OR 135 OR 136 OR 137 OR 138 OR 139 OR 140 OR 141 OR 142 OR 143 OR 144 OR 145 OR 146 OR 147 OR 148 OR 149 OR 150 OR 151 OR 152 OR 153 OR 154 OR 155 OR 156 OR 157 OR 158 OR 159 OR 160 OR 161 OR 162 OR 163 OR 164 OR 165 OR 166 OR 167 OR 168 OR 169 OR 170 OR 171 OR 172 OR 173 OR 174 OR 175 OR 176 OR 177 OR 178 OR 179 OR 180 OR 181 OR 182 OR 183) Online appendix C: Search terms for Embase

'diabetes mellitus'/exp OR 'diabetes' OR diabet* OR iddm OR niddm OR 'hyperglycemia'/exp OR 'glucose blood level'/exp OR 'blood glucose' OR 'glucose homeostasis'/exp OR 'glucose regulation'/exp OR 'dysglycemia'/exp OR 'hemoglobin A1c'/exp OR hyper-glycemi* OR hyper-glycaemi* OR hyperglycemi* OR hyperglycaemi* OR hyperglycosemi* OR hyperglycosaemi* OR 'blood glucose' OR 'blood sugar' OR 'plasma glucose' OR 'plasma sugar' OR 'serum glucose' OR 'serum sugar' OR 'glucose homeostasis' OR 'glucose homeostatic' OR 'glucose regulation' OR dysglycem* OR dysglycaem* OR glycemi* OR glycaemi* OR glucosaemi* OR glucosemi* OR 'glycated haemoglobin A1c' OR 'Glycated Hemoglobin' OR 'glycated hemoglobin A1c' OR 'Glycated Hemoglobins' OR 'Glycohemoglobin A' OR 'glycosylated haemoglobin A1c' OR 'Glycosylated Hemoglobin' OR 'haemoglobin a (1c)' OR 'haemoglobin a 1c' OR 'haemoglobin A1c' OR 'haemoglobin aic' OR 'hb a (1c)' OR 'Hb A1' OR 'Hb A1a+b' OR 'Hb A1c' OR 'hba 1c' OR 'HbA1' OR 'hba1c' OR 'hemoglobin a (1c)' OR 'hemoglobin a 1c' OR 'Hemoglobin A(1)' OR 'Hemoglobin A, Glycated' OR 'Hemoglobin A, Glycosylated' OR 'Hemoglobin A1c, Glycated' OR 'Hemoglobin A1c, Glycosylated' OR 'hemoglobin aic' OR 1 'Hemoglobin, Glycosylated' OR 'Hemoglobins, Glycated' OR 'impaired fasting glucose'/exp OR prediabet* OR pre-diabet* OR 'impaired fasting glucose' OR 'glucose intolerance'/exp OR 'glucose tolerance test'/exp OR 'glucose intolerance' OR 'glucose intolerant' OR 'glucose tolerance' OR 'ogtt' OR 'glucose load' OR 'glucose loading test' OR 'glucose test' OR 'insulin resistance'/exp OR 'insulin sensitivity'/exp OR 'metabolic syndrome X'/exp OR 'homeostasis model assessment'/exp OR 'homeostasis model assessment' OR (homa NOT 'homa':au) OR 'insulin resistance' OR 'insulin resistant' OR 'insulin sensitivity' OR 'insulin sensitive' OR 'insulin insensitivity' OR 'insulin insensitive' OR 'metabolic syndrome' OR hyperinsuli* OR hyper-insuli* OR 'insulin' OR 'homeostasis model assessment' OR 'homeostatic model assessment' OR 'insulin test' OR 'hypoinsulinemia'/exp OR 'pancreas islet beta cell'/exp OR hypoinsulin* OR hypo-insulin* OR 'insulinopenia' OR 'beta cell' OR 'beta cells' OR 'beta islet cell' OR 'insulin producing cell' OR 'insulin producing cells' OR 'insulin secreting cell' OR 'insulin secreting cells' OR 'pancreas b cell' OR 'pancreas beta islet cell' OR 'pancreas islet b cell' OR 'pancreatic b cell' OR 'pancreatic islet b cell' OR 'pancreatic islet b cell'

2 'pesticide'/exp OR pesticid* 3 'insecticide'/exp OR insecticid* 4 'carbamate pesticide'/exp OR 'carbamates' OR 'carbamate' 5 'alanicarb' OR 'alanycarb' OR '83130-01-2':rn 6 'aldicarb'/exp OR 'aldicarb' OR 'temik' OR 'temick' OR '116-06-3':rn 7 'aminocarb'/exp OR 'aminocarb' OR 'matacil' OR '4-dimethylamino-3-tolyl-N-methylcarbamate' OR '2032-59-9':rn 8 'bendiocarb'/exp OR 'bendiocarb' OR 'ficam' OR '22781-23-3':rn 9 'benfuracarb'/exp OR 'benfuracarb' OR '82560-54-1':rn 10 'butocarboxim' OR '34681-10-2':rn 11 'butoxycarboxim' OR '34681-23-7':rn 12 'carbaril'/exp OR 'carbaryl' OR 'carbaril' OR 'carbyl' OR '63-25-2':rn OR '27636-33-5':rn OR '3197-92-0':rn 13 'carbofuran'/exp OR 'carbofuran' OR 'furadan' OR '1563-66-2':rn 14 'carbosulfan'/exp OR 'carbosulfan' OR '55285-14-8':rn 15 'ethiofencarb'/exp OR 'croneton' OR 'ethiofencarb' OR 'kroneton' OR '29973-13-5':rn 16 'fenobucarb'/exp OR 'BPMC' OR 'fenobucarb' OR '3766-81-2':rn 17 'Fenothiocarb' OR '62850-32-2':rn 18 'fenoxycarb'/exp OR 'fenoxycarb' OR 'ethyl(2-(4-phenoxyphenoxy)ethyl)carbamate' OR '72490-01-8':rn 19 'formetanate'/exp OR 'formetanate' OR '22259-30-9':rn OR '23422-53-9':rn 20 'deltanit' OR 'furathiocarb' OR 'furatiocarb' OR '65907-30-4':rn 'dimethylcarbamic acid 1 isopropyl 3 methyl 5 pyrazolyl ester'/exp OR 'isolan'/exp OR ('isolan' NOT 'isolan':au) OR '1-isopropyl-3-methyl-5- pyrazolyldimethylcarbamate' OR 'dimethylcarbamic acid 1 isopropyl 3 methyl 5 pyrazolyl ester' OR '1 isopropyl 3 methyl 5 pyrazolyl 21 dimethylcarbamate' OR '1 isopropyl 3 methylpyrazol 5 yl dimethylcarbamate' OR 'dimethylcarbamic acid 1 isopropyl 3 methylpyrazol 5 yl ester' OR 'primin' OR 'primine' OR '119-38-0':rn 22 'isoprocarb'/exp OR 'isoprocarb' OR 'phenyl-2-(1-methylethyl)methylcarbamate' OR '2-isopropylphenyl methylcarbamate' OR '2631-40-5':rn 23 'methiocarb'/exp OR 'methiocarb' OR 'mercaptodimethur' OR '2032-65-7':rn 24 'methomyl'/exp OR 'methomyl' OR 'lannate' OR '16752-77-5':rn OR '19928-35-9':rn OR '19928-37-1':rn 25 'metolcarb'/exp OR 'metolcarb' OR '1129-41-5':rn 26 'oxamyl'/exp OR 'oxamyl' OR 'vydate' OR '23135-22-0':rn 27 'pirimicarb'/exp OR 'pirimicarb' OR 'pirimor' OR 'pyrimor' OR 'ZZ-Aphox' OR '23103-98-2':rn 'propoxur'/exp OR 'propoxur' OR 'O-Isopropoxyphenylmethylcarbamate' OR 'O Isopropoxyphenylmethylcarbamate' OR 'Unden' OR 'sendran' OR 28 'aprocarb' OR '114-26-1':rn 29 'thiodicarb'/exp OR 'thiodicarb' OR '59669-26-0':rn 30 'thiofanox'/exp OR 'thiofanox' OR 'dacamox' OR 'thiofanocarb' OR '39196-18-4':rn OR '75013-98-8':rn 31 'triazamate' OR '110895-43-7':rn OR '112143-82-5':rn 32 'trimethacarb' OR 'landrin' OR 'landrina' OR '2686-99-9':rn 'xmc' OR 'carbaron' OR '3,5-xylyl methylcarbamate' OR '3,5-dimethylphenyl methylcarbamate' OR 'cosban' OR 'maqbarl' OR 'macbal' OR '2655- 33 14-3':rn 34 'xylylcarb' OR '2425-10-7':rn Online appendix C: Search terms for Embase

'organophosphate pesticide'/exp OR 'organophosphate'/exp OR 'organophosphate insecticide'/exp OR 'organophosphate'/exp OR 35 'organophosphates' OR 'organophosphate' OR 'organothiophosphates' OR 'organothiophosphate' OR 'organophosphorus' OR 'organophosphorous' OR 'organothiophosphorus' OR 'organothiophosphorous'

36 'acephate'/exp OR 'acephate' OR 'O,S-dimethyl N-acetyl phosphoramidothioate' OR 'orthene' OR '30560-19-1':rn OR '115096-11-2':rn 37 'amiton'/exp OR 'amiton' OR 'O,O-diethyl S-(diethylaminoethyl) phosphorothiolate' OR '78-53-5':rn 38 'azamethiphos'/exp OR 'azamethiphos' OR '35575-96-3':rn 'azinphos ethyl'/exp OR 'azinphos ethyl' OR 'azinphos-ethyl' OR 'azinphosethyl' OR 'ethyl azinphos' OR 'ethyl-azinphos' OR 'ethylazinphos' OR 39 '2642-71-9':rn 'azinphos methyl'/exp OR 'azinphosmethyl' OR 'azinphos-methyl' OR 'azinphos methyl' OR 'methylazinphos' OR 'methyl-azinphos' OR 'methyl 40 azinphos' OR 'guthion' OR '86-50-0':rn 41 'cadusafos'/exp OR 'cadusafos' OR 'O-ethyl, S-bis(1-methylpropyl)phosphorodithioate' OR '95465-99-9':rn 42 'chlorethoxyfos' OR '54593-83-8':rn OR '3957-63-9':rn 'clofenvinfos'/exp OR 'chlorfenvinphos' OR 'clofenvinfos' OR 'chlorphenvinphos' OR 'dermaton' OR 'birlane' OR '470-90-6':rn OR '18708-87-7':rn 43 OR '135373-33-0':rn 44 'chlormephos' OR '24934-91-6':rn 45 'chlorpyrifos'/exp OR 'chlorpyrifos' OR 'lorsban' OR 'dursban' OR '2921-88-2':rn 'chlorpyrifos methyl'/exp OR 'chlorpyrifos-methyl' OR 'chlorpyrifos methyl' OR 'chlorpyrifosmethyl' OR 'methyl-chlorpyrifos' OR 'methyl 46 chlorpyrifos' OR 'methylchlorpyrifos' OR 'dowco 214' OR 'reldan' OR '5598-13-0':rn 47 'coumafos'/exp OR 'coumaphos' OR 'asuntol' OR '56-72-4':rn 48 'crufomate'/exp OR 'crufomate' OR 'ruelene' OR 'ruerene' OR '299-86-5':rn 49 'cyanophos'/exp OR 'cyanophos' OR 'cyanox' OR '2636-26-2':rn 'cyanofenphos'/exp OR 'cyanophenphos' OR 'cyanofenphos' OR 'surecide' OR '34460-46-3':rn OR '62421-61-8':rn OR '62421-62-9':rn OR '13067- 50 93-1':rn OR '62421-63-0':rn 51 'cythioate'/exp OR 'cythioate' OR 'cyflee' OR '115-93-5':rn 52 'demeton s methyl'/exp OR 'demeton-S-methyl' OR 'demeton s methyl' OR 'S-2-ethylthioethyl-O,O-dimethylphosphorothiolate' OR '919-86-8':rn 53 'dimpylate'/exp OR 'diazinon' OR 'dimpylate' OR 'neocidol' OR 'neotsidol' OR 'bazudine' OR '333-41-5':rn 'dichlorvos'/exp OR 'dichlorvos' OR 'ddvp' OR 'dichlofos' OR 'dimethyl dichlorovinyl phosphate' OR 'phosphoric acid 2,2-dichloroethenyl 54 dimethyl ester' OR 'phosphoric acid 2,2 dichloroethenyl dimethyl ester' OR 'dichlorophos' OR 'divipan' OR 'novotox' OR 'dichlorfos' OR 'dichlorofos' OR 'dichlorovos' OR 'dichlorphos' OR '62-73-7':rn 55 'dicrotophos'/exp OR 'dicrotophos' OR 'carbicron' OR 'bidrin' OR '141-66-2':rn OR '3735-78-2':rn 56 'dimethoate'/exp OR 'dimethoate' OR 'phosphamide' OR 'rogor' OR '60-51-5':rn 57 'dimethylvinphos' OR '2274-67-1':rn 'disulfoton'/exp OR 'disulfoton' OR 'thiodemeton' OR 'di-syston' OR 'di syston' OR 'disyston' OR 'demeton' OR 'thiometon ethyl' OR 'thiometon- 58 ethyl' OR 'thiometonethyl' OR 'ethyl thiometon' OR 'ethyl-thiometon' OR 'ethylthiometon' OR '298-04-4':rn

'phenylphosphonothioic acid o ethyl o (4 nitrophenyl) ester'/exp OR 'phenylphosphonothioic acid, 2-ethyl 2-(4-nitrophenyl) ester' OR 'phenylphosphonothioic acid o ethyl o (4 nitrophenyl) ester' OR 'O-Ethyl-O-(4-nitrophenyl)phenylphosphonothioate' OR 'benzenephosphonothioic acid o ethyl o 4 nitrophenyl ester' OR 'epn' OR 'ethyl 4 nitrophenyl phenylphosphonothioate' OR 'o (4 nitrophenyl) o ethyl phenylphosphonothioate' OR 'o ethyl o (4 nitrophenyl) phenylthiophosphonate' OR 'o ethyl o (4 nitrophenyl) phenylphosphonothioate' OR 'o ethyl o 4 nitrophenyl benzenephosphonothioate' OR 'o ethyl o 4 nitrophenyl benzenethiophosphonate' OR 'o ethyl o 4 nitrophenyl 59 phenylphosphonothioate' OR 'o ethyl o 4 nitrophenyl phenylphosponothionate' OR 'o ethyl o 4 nitrophenylphenylphosphonothioic acid' OR 'o ethyl o para nitrophenyl phenylphosphonothioate' OR 'o ethyl o para nitrophenyl phenylphosphonothionate' OR 'o ethyl o para nitrophenyl phenylthiophosphonate' OR 'phenylphosphonethioic acid o ethyl o para nitrophenyl ester' OR 'phenylphosphonothioic acid ethyl 4 nitrophenyl ester' OR 'phenylphosphonothioic acid o ethyl o 4 nitrophenyl ester' OR 'phenylphosphonothioic acid o ethyl o para nitrophenyl ester' OR 'phenylphosphonothioic acid, 2 ethyl 2 (4 nitrophenyl) ester' OR 'phenylphosphonothioic acid, 2-ethyl 2- (4-nitrophenyl) ester' OR 'phenylphosphonothioic acid, o-ethyl o- (4-nitrophenyl) ester') NOT 'emphysematous pyelonephritis' OR '2104-64-5':rn

60 'ethion'/exp OR 'ethion' OR 'diethion' OR 'ethopaz' OR 'nialate' OR 'ethyl methylene phosphorodithioate' OR 'diethion' OR '563-12-2':rn 'ethoprop'/exp OR 'ethoprophos' OR 'ethoprop' OR 'O-ethyl S,S-diprophyl phosphorodithioate' OR 'mocap' OR 'o ethyl s, s dipropyl 61 phosphorodithioate' OR 'o ethyl s, s dipropylphosphorodithioate' OR 'phosphorodithioic acid o ethyl s, s dipropyl ester' OR 'prophos' OR '13194- 48-4':rn 'etrimfos'/exp OR 'etrimfos' OR 'ekamet' OR 'o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioic acid o, o dimethyl ester' OR 'o, o dimethyl o (6 62 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioate' OR 'o, o dimethyl o (6 ethoxy 2 ethylpyrimidin 4 yl) phosphorothioate' OR 'phosphorothioic acid o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidinyl) ester' OR '38260-54-7':rn 'famphur'/exp OR 'famophos' OR 'O,O-dimethyl O-p-(dimethylsulfamoyl)phenylphosphorothioate' OR 'famphur' OR 'warbex' OR 'varbex' OR '52- 63 85-7':rn Online appendix C: Search terms for Embase

'fenamiphos'/exp OR 'fenamiphos' OR 'ethyl 4-(methylthio)m-tolyl isopropylphosphoroamidate' OR 'phenamiphos' OR 'nemacur' OR '22224-92- 64 6':rn 'fenitrothion'/exp OR 'fenitrothion' OR 'metathion' OR 'dolithion' OR 'nitrophos' OR 'sumithion' OR 'sumithione' OR 'accothion' OR 'agrothion' OR 'dimethyl (3 methyl para nitrophenyl) phosphorothioate' OR 'fenitrotion' OR 'fenthrothion' OR 'fentrothion' OR 'folithion' OR 'nuvanol' OR 'o, o dimethyl o (3 methyl 4 nitrophenyl) phosphorothioate' OR 'o, o dimethyl o (3 methyl 4 nitrophenyl) thionophosphate' OR 'o, o dimethyl o 65 (3 methyl 4 nitrophenyl) thiophosphate' OR 'o, o dimethyl o (3 methyl para nitrophenyl) phosphorothioate' OR 'o, o dimethyl o (4 nitro 1, 3 tolyl) phosphorothioate' OR 'o, o dimethyl o (para nitro meta tolyl) phosphorothioate' OR 'o, o dimethyl o para nitro meta tolylphosphorothioate' OR 'phenitrothion' OR '122-14-5':rn

'fensulfothion'/exp OR 'fensulfothion' OR '(4 methylsulfinylphenyl) phosphorothioic acid diethyl ester' OR 'dasanit' OR 'dansit' OR 'diethyl (4 methylsulfinylphenyl) phosphorothioate' OR 'o, o diethyl o (4 methylsulfinyl) phosphorothioic acid' OR 'o, o diethyl o (4 methylsulfinylphenyl) 66 phosphorothioate' OR 'o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate' OR 'o, o diethyl o (para methylsulfinylphenyl) phosphorothioate' OR 'phosphorothioic acid o, o diethyl o (4 methylsulfinylphenyl) ester' OR 'terracur' OR '115-90-2':rn

'fenthion'/exp OR 'fenthion' OR 'mercaptophos' OR 'lebaycid' OR '4 methylmercapto 3 methylphenyl dimethyl thiophosphate' OR 'dimethyl (3 methyl para methylthiophenyl) phosphorothioate' OR 'dimethyl (4 methylthio) meta tolyl phosphorothioate' OR 'entex' OR 'fenthione' OR 'o, o dimethyl o (3 methyl 4 methylthiophenyl) phosphorothioate' OR 'o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate' OR 'o, o 67 dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate' OR 'o, o dimethyl o (3 methyl para methylthiophenyl) phosphorothioate' OR 'o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate' OR 'o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate' OR 'o, o dimethyl o (4 methylthio 3 methylphenyl) thiophosphate' OR 'queletox' OR 'spotton' OR 'tiguvon' OR '55-38-9':rn

'fonofos'/exp OR 'fonofos' OR 'dyfonate' OR 'dyphonate' OR 'ethylphosphonodithioic acid o ethyl s phenyl ester' OR 'fonophos' OR 'o ethyl s 68 phenyl ethylphosphonodithioate' OR '944-22-9':rn OR '62680-03-9':rn OR '62680-03-9':rn OR '62705-71-9':rn 'formothion'/exp OR 'formothion' OR 'anthio' OR 'antio' OR 'anfix' OR 's (n formyl n methylcarbamoylmethyl) o, o dimethyl phosphorodithioate' 69 OR '2540-82-1':rn 70 'fosthiazate'/exp OR 'fosthiazate' OR '(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate' OR '98886-44-3':rn 71 'heptenophos'/exp OR 'heptenophos' OR 'hostaquick' OR 'ragadan' OR '23560-59-0':rn 72 'imicyafos' OR '140163-89-9':rn 'isofenphos'/exp OR 'isofenphos' OR 'isophenphos' OR 'isopropylphosphoramidothioic acid o ethyl o 2 isopropoxycarbonylphenyl ester' OR 'o 73 ethyl o 2 isopropoxycarbonylphenyl isopropylphosphoramidothioate' OR 'oftanol' OR '25311-71-1':rn OR '103982-07-6':rn OR '103982-06-5':rn

74 'isocarbophos'/exp OR 'isocarbophos' OR 'O-2-isopropoxycarbonylphenyl O-methyl phosphoramidothioate' OR '24353-61-5':rn 75 'isoxathion'/exp OR 'isoxathion' OR '18854-01-8':rn 'leptophos'/exp OR 'leptophos' OR 'phosvel' OR 'o (2, 5 dichloro 4 bromophenyl) o methylphenylthiophosphonate' OR 'phenylphosphonothioic 76 acid o (4 bromo 2, 5 dichlorophenyl) o methyl ester' OR '21609-90-5':rn OR '73307-67-2':rn OR '73307-66-1':rn 77 'malaoxon'/exp OR 'malaoxon' OR 'malathion oxon' OR '1634-78-2':rn 'malathion'/exp OR 'karbofos' OR 'carbophos' OR 'carbafos' OR 'carbofos' OR 'prioderm' OR 'sadophos' OR 'cythion' OR 'derbac m' OR 'fosfotion' OR 'fyfanon' OR 'kypfos' OR 'lusap' OR 'malathione' OR 'malathon' OR 'malthion' OR 'malthione' OR 'nalathion' OR 'o, o dimethyl 78 dithiophosphate of diethyl mercaptosuccinate' OR 'o, o dimethyldithiophosphate derivative of diethyl succinate' OR 'organoderm' OR 'ovide' OR 'phosphothion' OR 'prioderm' OR '(1, 2 dicarbethoxyethyl) o, o dimethyl phosphorodithioate' OR 's (1, 2 dicarbethoxyethyl) o, o dimethyldithiophosphate' OR 'sadofos' OR 'zithiol' OR 'maldison' OR 'mercaptothion' OR '121-75-5':rn 'mecarbam'/exp OR 'mecarbam' OR 'S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl)-O,O-diethylphosphorodithioate' OR 'Murfatox' OR '2595- 79 54-2':rn 80 'methacrifos' OR '30864-28-9':rn OR '62610-77-9':rn 'methamidophos'/exp OR 'methamidophos' OR 'O,S-dimethylphosphoroamidothioate' OR 'metamidophos' OR 'tamaron' OR '10265-92-6':rn OR 81 '65960-97-6':rn OR '115182-35-9':rn 82 'methidathion'/exp OR 'methidathion' OR 'metidathion' OR 'Supracide' OR '950-37-8':rn 'mevinphos'/exp OR 'mevinphos' OR 'fosdrin' OR 'phosdrin' OR 'fosdrine' OR '(1 carbomethoxy) 1 propen 2 yl dimethyl phosphate' OR '(2 carbomethoxy 1 methylvinyl) dimethyl phosphate' OR '(carbomethoxypropen 2 yl) dimethyl phosphate' OR '(carbomethoxypropen 2 yl) 83 dimethyl phosphate' OR '(carbomethoxypropen 2 yl) dimethylphosphate' OR '1 carbomethoxy 1 propen 2 yl dimethyl phosphate' OR '1 carbomethoxy 1 propen 2 yl dimethylphosphate' OR '1 carbomethoxy 1 propen 2 yldimethyl phosphate' OR '7786-34-7':rn OR '298-01-1':rn 84 'mipafox'/exp OR 'mipafox' OR 'bis (isopropylamino) fluorophosphine oxide' OR 'isopestox' OR '371-86-8':rn 'monocrotophos'/exp OR 'monocrotophos' OR 'nuvacron' OR 'azodrin' OR '3 (dimethoxyphosphinoyloxy) n methyl cis crotonamide' OR '3 85 (dimethoxyphosphinyloxy) n methyl cis crotonamide' OR '3 (dimethoxyphosphinyloxy) n methylcrotonamide' OR '3 [(dimethoxyphosphinoyl) oxy] n methyl cis crotonamide' OR '6923-22-4':rn OR '2157-98-4':rn Online appendix C: Search terms for Embase

'naled'/exp OR 'naled' OR '1, 2 dibromo 2, 2 dichloroethyl dimethyl phosphate' OR '1, 2 dibromo 2, 2 dichloroethyl dimethylphosphate' OR '1, 2 dibromo 2, 2 dichloroethyldimethyl phosphate' OR 'alvora' OR 'bromex' OR 'dibrom' OR 'o, o dimethyl o (1, 2 dibromo 2, 2 dichloroethyl) 86 phosphate' OR 'phosphoric acid (1, 2 dibromo 2, 2 dichloroethyl) dimethyl ester' OR 'phosphoric acid 1, 2 dibromo 2, 2 dichloroethyl dimethyl ester' OR 'bromchlophos' OR '300-76-5':rn

'omethoate'/exp OR 'dimethoxon' OR 'omethoate' OR 'o-methoate' OR 'folimat' OR 'o, o dimethyl s (n methylcarbamoylmethyl) 87 phosphorothioate' OR 'phosphorothioic acid o, o dimethyl s (n methylcarbamoylmethyl) ester' OR '1113-02-6':rn 'oxydemeton methyl'/exp OR 'methyl demeton' OR 'methyl-demeton' OR 'oxydemeton methyl' OR 'oxydemeton-methyl' OR 'oxydemeton methyl' OR 'oxydemeton-methyl' OR 'oxydemetonmethyl' OR 'methyl oxydemeton' OR 'methyl-oxydemeton' OR 'methyloxydemeton' OR 88 'demeton-methyl' OR 'O,O-dimethyl S-(2-(ethylsulfinyl)ethyl)phosphorothioate' OR 'metasystox' OR 'methylmercaptophos oxide' OR '301-12- 2':rn 'parathion'/exp OR 'alkron' OR 'aphamite' OR 'corthion' OR 'diethyl nitrophenyl thiophosphate' OR 'diethyl p nitrophenyl monothiophosphate' OR 'diethylparathion' OR 'dimethyl para nitrophenolthiophosphate' OR 'ecatox' OR 'ekatox' OR 'ethyl parathion' OR 'ethylparathion' OR 'etilon' OR 'folidol' OR 'isoparathion' OR 'niran' OR 'nitrostigmine' OR 'o, o diethyl o (4 nitrophenyl) phosphorothioate' OR 'o, o diethyl o (4 nitrophenyl) 89 thiophosphate' OR 'o, o diethyl o (para nitrophenyl) phosphorothioate' OR 'o, o diethyl o p nitrophenyl phosphorothioate' OR 'paraphos' OR 'parathion' OR 'phosphemol' OR 'phosphorothioic acid o, o diethyl o (4 nitrophenyl) ester' OR 'phosphostigmine' OR 'thiophos' OR 'tiofos' OR '56-38-2':rn

'parathion methyl'/exp OR 'methyl parathion' OR 'methyl-parathion' OR 'methylparathion' OR 'parathion methyl' OR 'parathionmethyl' OR 'parathion-methyl' OR 'demethylfenitrothion' OR 'dimethyl para nitrophenyl phosphorothioate' OR 'dimethyl para nitrophenylphosphorothioate' OR 'dimethyl (para nitrophenyl) phosphorothioate' OR 'dimethylnitrophenylthiophosphate' OR 'dimethylparathion' OR 'fenitrothion, demethyl' OR 'metaphos' OR 'norfenitrothion' OR 'o, o dimethyl o (para nitrophenyl) phosphorothioate' 90 OR 'o, o dimethyl o (para nitrophenyl) thiophosphate' OR 'o, o dimethyl o (para nitrophenyl) phosphorothioate' OR 'o, o dimethyl o (para nitrophenyl) phosphorothionate' OR 'o, o dimethyl o para nitrophenyl phosphorothioate' OR 'o, o dimethyl para nitrophenyl phosphorothioate' OR 'phosphorothioic acid o, o dimethyl o (4 nitrophenyl) ester' OR 'vofatox' OR 'vophatox' OR 'wofatox' OR 'dalf' OR 'metaphos' OR '298-00- 0':rn

'phenthoate'/exp OR 'phenthoate' OR 'elsan' OR 'phendal' OR 'cidial' OR 'cidiale' OR 'dimethenthoate' OR 'fenthoate' OR 'phosphorodithioic 91 acid s (alpha carbethoxybenzyl) o, o dimethyl ester' OR 's alpha ethoxycarbonylbenzyl o, o dimethyl phosphorodithioate' OR 'tannone' OR 'o,o- dimethyl S-alpha-ethoxycarbonylbenzylphosphorodithioate' OR '2597-03-7':rn OR '61361-99-7':rn OR '61362-00-3':rn OR '61391-87-5':rn 'phorate'/exp OR phorate OR 'phorate' OR 'diethyl ethylthiomethyl phosphorodithioate' OR 'l 11 6' OR 'o, o diethyl s (ethylthiomethyl) 92 phosphorodithioate' OR 'o, o diethyl s (ethylthiomethyl) phosphorodithioate' OR 'phorates' OR 'phosphorodithioic acid o, o diethyl s [(ethylthio) methyl] ester' OR 'thimet' OR 'timet' OR '298-02-2':rn 'phosalone'/exp OR 'phosalone' OR 'phozalone' OR 'phoazlone' OR 'fozalone' OR 'fosalone' OR 'fosalon' OR 'o, o diethyl s (6 chloro 2 93 oxobenzoxazolin 3 ylmethyl) phosphorodithioate' OR 's (6 chloro 2 oxobenzoxazolin 3 yl) methyl diethyl phosphorothiolothioate' OR 'zolone' OR 'benzophosphate' OR '2310-17-0':rn 'phosmet'/exp OR 'phosmet' OR 'fosmet' OR 'imidan' OR 'n (mercaptomethyl) phthalimide s (o, o dimethyl) phosphorodithioate' OR 'n (mercaptomethyl) phthalimide s (o, o dimethylphosphorodithioate)' OR 'o, o dimethyl s (phthalimidomethyl) phosphorodithioate' OR 'o, o 94 dimethyl s phthalimidomethyl phosphorodithioate' OR 'phosphorodithioic acid o, o dimethyl s phthalimidomethyl ester' OR 'porect' OR 'phthalophos' OR '732-11-6':rn 'phosphamidon'/exp OR 'phosphamidon' OR '2 chloro n, n diethyl 3 hydroxycrotonamide dimethyl phosphate' OR 'dimecron' OR 'dimethyl (2 95 chloro 1 diethylaminocroton 3 yl) phosphate' OR 'liromidon' OR 'o, o dimethyl o (2 chloro 1 diethylaminocroton 3 yl) phosphate' OR '13171-21- 6':rn OR '23783-98-4':rn 'phoxim'/exp OR 'phoxim' OR 'phenylglyoxylonitrile oxime o,o-diethylphosphorothioate' OR 'valekson' OR 'valexon' OR 'sebacil' OR 'foxim' OR 'o 96 (alpha cyanobenzylideneamino) o, o diethyl phosphorothioate' OR 'o, o diethyl o (alpha cyanobenzylideneamino) phosphorothioate' OR 'phenylglyoxylonitrile oxime o, o diethylphosphorothioate' OR 'volaton' OR '14816-18-3':rn OR '217075-81-5':rn

'pirimiphos methyl' OR 'pirimiphosmethyl' OR 'pirimiphos-methyl' OR 'methyl-pirimiphos' OR 'methyl pirimiphos' OR 'methylpirimiphos' OR 'o- 97 (2-(diethylamino)-6-methyl-4-pyrimidinyl) o,o- dimethylphosphorothioate lic' OR 'piritione' OR 'actellic' OR 'aktel' OR '29232-93-7':rn

'profenofos'/exp OR profenofos OR 'profenofos' OR 'curacron' OR 'selecron' OR 'o (4 bromo 2 chlorophenyl) o ethyl s propyl phosphorothioate' 98 OR 'phosphorothioic acid o (4 bromo 2 chlorophenyl) o ethyl s propyl ester' OR '41198-08-7':rn OR '81123-19-5':rn OR '81116-98-5':rn 99 'propetamphos'/exp OR 'propetamphos' OR '31218-83-4':rn 100 'prothiofos'/exp OR 'prothiophos' OR 'prothiofos' OR 'tokuthion' OR 'tukuthion' OR '34643-46-4':rn 'pyraclofos'/exp OR 'pyraclofos' OR 'o-(1-(4-chlorophenyl)-4-pyrazolyl) o-ethyl S-propyl phosphorothioate' OR '77458-01-6':rn OR '89784-60- 101 1':rn 'pyridaphenthion'/exp OR 'pyridafenthion' OR 'o,o-diethyl o-(3-oxo-2-phenyl-2H-pyridazin-6- yl) phosphorothioate' OR 'pyridaphenthion' OR 102 'ofunack' OR 'o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) phosphorothioate' OR 'phosphorothioic acid o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) ester' OR 'pyridaphenthione' OR '119-12-0':rn Online appendix C: Search terms for Embase

'quinalphos'/exp OR 'quinalphos' OR 'diethylquinalphione' OR 'o,o-diethyl-o-(quinoxalinyl-(2))thionophosphate' OR 'o,o-diethyl-o- 103 (quinoxalyl)phosphorothioate' OR 'o, o diethyl o (2 quinoxalinyl) phosphorothioate' OR 'phosphorothioic acid o, o diethyl o (2 quinoxalinyl) ester' OR 'bayrusil' OR 'ekalux' OR 'bayer 77049' OR '13593-03-8':rn

104 'sulfotep'/exp OR 'sulfotepp' OR 'sulfotep' OR 'ethyl thiopyrophosphate' OR 'asymmetric tetraethyl dithiopyrophosphate' OR '3689-24-5':rn 105 'tebupirimphos' OR '96182-53-5':rn 106 'temefos'/exp OR 'temefos' OR 'temephos' OR 'difos' OR 'abathion' OR '3383-96-8':rn 'terbufos'/exp OR 'terbufos' OR 'o,o-diethyl s((tert-butylthio)methyl)phosphorodithioate' OR 'o, o diethyl s (tert butylthio) 107 methylphosphorodithioate' OR '13071-79-9':rn 'stirofos'/exp OR 'tetrachlorvinphos' OR 'stirofos' OR 'gardona' OR 'rabon' OR '2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethylphosphate' OR '2 108 chloro 1 (2, 4, 5 trichlorophenyl) vinyldimethylphosphate' OR 'phosphoric acid 2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethyl ester' OR 'stirophos' OR 'tetrachlorofenvinphos' OR '961-11-5':rn OR '22248-79-9':rn

'thiometon'/exp OR 'thiometon' OR 'ekatin' OR 'intration' OR 'aasystem' OR 'duphar dimeaat' OR 'ecatin' OR 'intrathion' OR 'intrathione' OR 109 'luxan' OR 'o, o dimethyl s (2 ethylthioethyl) phosphorodithioate' OR 'o, o dimethyl s (2 ethylthioethyl) phosphorodithioate' OR 'o, o dimethyl s ethylthioethyl phosphorodithioate' OR 'sysmeton' OR '640-15-3':rn

'triazophos'/exp OR 'triazophos' OR '1-phenyl-3-(o,o-diethylthiophosphoryl)-1,2,4- triazole' OR 'hostathion' OR 'o, o diethyl o (1 phenyl 1h 1, 2, 110 4 triazol 3 yl) phosphorothioate' OR 'phosphorothioic acid o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) ester' OR '24017-47-8':rn 'tributyl phosphorotrithioite'/exp OR 'merphos' OR 'tributyl phosphorotrithioite' OR 's,s,s-tributyl phosphorotrithioite' OR 'folex' OR 'tributyl- 111 phosphorotrithioite' OR 'tributylphosphorotrithioite' OR 'phosphorotrithioite tributyl' OR 'phosphorotrithioite-tributyl' OR 'phosphorotrithioitetributyl' OR '150-50-5':rn

'metrifonate'/exp OR 'chlorophos' OR 'chlorofos' OR 'metrifonate' OR 'dipterex' OR 'dylox' OR 'neguvon' OR 'ricifon' OR 'bilarcil' OR 'bilacil' OR 'bilharcil' OR 'foschlor' OR '2, 2, 2 trichloro 1 hydroxyethylphosphonic acid dimethyl ester' OR 'bay a 9826' OR 'bay a9826' OR 'bayer 15922' OR 'bayer 2349' OR 'bayer l 13-59' OR 'bayer l 1359' OR 'bayer l13-59' OR 'bayer l1359' OR 'combot' OR 'dimethyl (2, 2, 2 trichloro 1 hydroxyethyl) 112 phosphonate' OR 'dyrex' OR 'dyvon' OR 'etfoschlor' OR 'flibol e' OR 'masoten' OR 'metriphonate' OR 'metrifonate' OR 'metrofinate' OR 'o, o dimethyl 1 hydroxy 2, 2, 2 trichloroethylphosphonate' OR 'o, o dimethyl 2, 2, 2 trichloro 1 hydroxyethylphosphonate' OR 'o, o dimethyl (1 hydroxy 2, 2, 2 trichlorethyl) phosphonate' OR 'promem' OR 'promen' OR 'trichlorfon' OR 'trichlorofon' OR 'trichlorophon' OR 'trichlorophone' OR 'trichlorphon' OR 'trichlorphone' OR 'tugon' OR 'dipterex' OR '52-68-6':rn OR '56042-26-3':rn OR '56042-27-4':rn

113 'vamidothion'/exp OR 'o,o-dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl)phosphorothioate' OR 'kilval' OR 'vamidothion' OR '2275-23-2':rn 114 'fiproles' OR 'fiprole' 115 'ethiprole' OR '181587-01-9':rn 116 'fipronil'/exp OR 'fipronil' OR 'fiprex' OR '120068-37-3':rn 117 'pyrethroid'/exp OR 'pyrethrin' OR 'pyrethrins' OR 'pyrethroid' OR 'pyrethroids' OR 'ipevet' OR 'ipevetex' OR 'pyrethrasin' 118 'acrinathrin'/exp OR 'acrinathrin' OR '101007-06-1':rn 'allethrin'/exp OR 'allethrin' OR 'allethrins' OR '3 allyl 2 methyl 4 oxo 2 cyclopenten 1 yl chrysanthemate' OR '3 allyl 2 methyl 4 oxo 2 119 cyclopentenyl chrysanthemate' OR 'allethrine' OR 'allyl cinerin' OR 'allethroxyl d, l cis, trans chrysanthemate' OR 'pynamin' OR 'pyresyn' OR '28434-00-6':rn OR '584-79-2':rn OR '34624-48-1':rn OR '42534-61-2 3972-20-1':rn OR '84030-86-4':rn

120 'bifenthrin'/exp OR 'bifenthrin' OR 'bifenthrine' OR 'fmc 54800' OR 'fmc54800' OR 'talstar' OR '82657-04-3':rn OR '439680-76-9':rn 121 'bioallethrin'/exp OR 'bioallethrin' OR 'allethrin, bio' OR 's-bioallethrin' OR 'd-trans-allethrin' 122 'bioresmethrin'/exp OR 'bioresmethrin' OR 'trans-resmethrin' OR 'ru 11484' OR 'd-trans-resmethrin' OR '28434-01-7':rn OR '10453-55-1':rn 'cismethrin'/exp OR 'cismethrin' OR '5-benzyl-3-furylmethyl(1.R)-cis-chrysanthemate' OR 'NRDC 119' OR 'cis (+) resmethrin' OR 'methrin, cis' OR 123 'resmethrin, cis (+)' OR '35764-59-1':rn 124 'cycloprothrin' OR '63935-38-6':rn 'cyfluthrin'/exp OR 'beta cyfluthrin'/exp OR 'cyfluthrin' OR 'oms 2012' OR 'oms-2012' OR 'beta-cyfluthrin' OR 'beta cyfluthrin' OR 'bay fcr 1272' 125 OR 'bay fcr1272' OR 'baythroid' OR 'baytroid' OR 'ciflutrin' OR 'cyfloxylate' OR 'fcr 1272' OR 'fcr1272' OR '68359-37-5':rn

'cyhalothrin'/exp OR 'cyhalothrin' OR 'lambda-cyhalothrin' OR 'lambdacyhalothrin' OR 'pp 321' OR 'oms 3021' OR 'oms-3021' OR 'gamma 126 cyhalothrin' OR 'gamma-cyhalothrin' OR 'gammacyhalothrin' OR '68085-85-8':rn OR '91465-08-6':rn OR '76703-62-3':rn Online appendix C: Search terms for Embase

'cypermethrin'/exp OR cypermethrin OR '2 (2, 2 dichlorovinyl) 3, 3 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester' OR '3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester' OR '3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid meta phenoxymandelonitrile ester' OR 'alfa cypermethrin' OR 'alfa methrin' OR 'alfa methrine' OR 'alfacypermethrin' OR 'alfamethrin' OR 'alfamethrine' OR 'alpha cyano 3 phenoxybenzyl 3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylate' OR 'alpha cypermethrin' OR 'alpha cypermethrine' OR 'alpha-cypermethrin' OR 'alphacypermethrin' OR 'alpha methrin' OR 'alpha methrine' OR 'alphacypermethrin' OR 'alphamethrin' OR 'alphamethrine' OR 'barricade' OR 'beta cypermethrine' OR 127 'beta cypermethrin' OR 'beta-cypermethrin' OR 'betacypermethrin' OR 'ccn 52' OR 'ccn52' OR 'cipermethrin' OR 'cis cypermethrin' OR 'cypermethrine' OR 'cypermetrin' OR 'flectron' OR 'fmc 30980' OR 'fmc30980' OR 'nrdc 149' OR 'nrdc 182' OR 'nrdc149' OR 'nrdc182' OR 'wl 43467' OR 'wl 85871' OR 'wl43467' OR 'wl85871' OR 'supermethrin' OR 'supercypermethrin' OR 'cymbush' OR 'fastac 50EC' OR 'fendona' OR 'beta-cipermetrina' OR 'theta cypermethrin' OR 'theta-cypermethrin' OR 'thetacypermethrin' OR 'zeta cypermethrin' OR 'zeta-cypermethrin' OR 'zetacypermethrin' OR '71697-59-1':rn OR '52315-07-8':rn OR '67375-30-8':rn OR '97955-44-7':rn OR '72204-44-5':rn OR '65731-84-2':rn OR '83860-32-6':rn OR '65732-07-2':rn OR '1315501-18-8':rn

'cyphenothrin'/exp OR 'cyphenothrin' OR 'cis-cyphenothrin' OR 'alpha cyano 3 phenoxybenzyl chrysanthemate' OR 'chrysanthemic acid alpha 128 cyano 3 phenoxybenzyl ester' OR '39515-40-7':rn 'deltamethrin'/exp OR 'decamethrin' OR 'deltamethrin' OR 'butox' OR 'oms 1998' OR 'difexon' OR 'k-othrin' OR 'nrdc 161' OR 'decis' OR 'deltanil' 129 OR 'k othrine' OR 'pediculosane' OR '52820-00-5':rn OR '120710-24-9':rn OR '52918-63-5':rn OR '120710-25-0':rn OR '55700-99-7':rn OR '120710-23-8':rn OR '80845-12-1':rn 'empenthrin' OR '1-ethynyl-2-methyl-2-pentenyl chrysanthemate' OR 's 2852f' OR 's-2852f' OR 'vaporthrin' OR 'd-empenthrin' OR '54406-48- 130 3':rn 131 'esfenvalerate' OR '66230-04-4':rn 'etofenprox'/exp OR 'ethofenprox' OR '2-(4-ethoxyphenyl)-2-methylpropyl-3-phenoxybenzyl ether' OR 'etofenprox' OR 'Trebon' OR '80844-07- 132 1':rn 'fenpropathrin'/exp OR 'fenpropathrin' OR '(alpha cyano 3 phenoxybenzyl) 2, 2, 3, 3 tetramethylcyclopropanecarboxylate' OR '2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid (alpha cyano 3 phenoxybenzyl) ester' OR '2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid alpha 133 cyano 3 phenoxybenzyl ester' OR 'alpha cyano 3 phenoxybenzyl 2, 2, 3, 3 tetramethylcyclopropanecarboxylate' OR 'fenpropanate' OR 'meothrin' OR '39515-41-8':rn

'fenvalerate'/exp OR 'fenvalarate' OR '(alpha cyano 3 phenoxybenzyl) 2 (4 chlorophenyl) 3 methylbutyrate' OR '2 (4 chlorophenyl) 3 methylbutyric acid (alpha cyano 3 phenoxybenzyl) ester' OR '2 (4 chlorophenyl) isovaleric acid alpha cyano 3 phenoxybenzyl ester' OR '3 phenoxymandelonitrile 2 (4 chlorophenyl) 2 isopropylacetate' OR 'alpha cyano 3 phenoxybenzyl alpha isopropyl 4 chlorophenylacetate' OR 'alpha isopropyl 4 chlorophenylacetic acid alpha cyano 3 phenoxybenzyl ester' OR 'arkofly' OR 'belmark' OR 'cyano (3 phenoxyphenyl) methyl 4 134 chloro alpha (1 methylethyl) benzeneacetate' OR 'ectrin' OR 'phenvalerate' OR 'pidrin' OR 'pydrin' OR 'pyrethroid sd 43775' OR 's 5602' OR 's- 5602' OR 'sd 43775' OR 'sumicidin' OR 'wl 43775' OR 'sumi-alpha' OR 'belmark' OR 'alpha-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3- methylbutyrate' OR 'alpha-cyano-3-phenoxybenzyl alpha-isopropyl-4-chlorophenyl acetate' OR '51630-58-1':rn OR '66267-77-4':rn OR '67614- 32-8':rn OR '67614-33-9':rn

'flucythrinate'/exp OR 'flucythrinate' OR '(alpha cyano 3 phenoxybenzyl) 4 difluoromethoxy alpha isopropylphenylacetate' OR '4 135 difluoromethoxy alpha isopropylphenylacetic acid alpha cyano 3 phenoxybenzyl ester' OR 'ac 222, 705' OR 'ac 222705' OR 'ac222, 705' OR 'ac222705' OR 'cyano (3 phenoxyphenyl) methyl 4 (difluoromethoxy) alpha (1 methylethyl) benzeneacetate' OR '70124-77-5':rn 136 'flumethrin'/exp OR 'flumethrin' OR 'bayticol' OR '69770-45-2':rn 137 'fluvalinate'/exp OR 'fluvalinate' OR 'tau-fluvalinate' OR 'tau fluvalinate' OR 'taufluvalinate' OR 'mavrik' OR '69409-94-5':rn OR '102851-06-9':rn 138 'halfenprox' OR 'brofenprox' OR '111872-58-3':rn 139 'imiprothrin'/exp OR 'imiprothrin' OR '72963-72-5':rn OR '173240-50-1':rn OR '70062-52-1':rn 140 'kadethrin'/exp OR 'kadethrin' OR '58769-20-3':rn 'permethrin'/exp OR permethrin OR 'permethrin' OR 'cis-permethrin' OR 'cis permethrin' OR 'cispermethrin' OR 'cis-(1rs)-permethrin' OR 'trans- permethrin' OR 'trans permethrin' OR 'transpermethrin' OR 'trans-(1rs)-permethrin' OR 'pp-557' OR 'pp 557' OR 'pp557' OR 's-3151' OR 's 3151' OR 's3151' OR 'elimite' OR 'fmc-33297' OR 'fmc 33297' OR 'fmc33297' OR 'nia-33297' OR 'nia 33297' OR 'nia33297' OR 'nittifor' OR 'nrdc-143' OR 'nrdc 143' OR 'nrdc143' OR 'nrdc-147' OR 'nrdc 147' OR 'nrdc147' OR 'acticin' OR 'armol' OR 'atroban' OR 'dronol' OR 'ectiban' OR 141 'ectomethrin' OR 'expar' OR 'gamabenceno plus' OR 'gamaderm' OR 'infectopedicul' OR 'klinits' OR 'loxazol' OR 'lyclear' OR 'mite-x' OR 'nedax plus' OR 'new-nok' OR 'novo-herklin 2000' OR 'oms 1821' OR 'perigen' OR 'permanone' OR 'permectrin' OR 'permicren' OR 'permite' OR 'piopel' OR 'quellada-p' OR 'scabmite' OR 'stockade' OR 'stockate' OR 'wl 43479' OR 'zehu-ze' OR '52645-53-1':rn OR '52341-32-9':rn OR '52341-33-0':rn OR '61949-76-6':rn 'phenothrin'/exp OR 'd-phenothrin' OR 'phenothrin' OR 'sumithrin' OR 's-2539' OR '3 phenoxybenzyl chrysanthemate' OR 'chrysanthemic acid 3 142 phenoxybenzyl ester' OR 'fenothrin' OR 'sumithrin' OR '26002-80-2':rn 'prallethrin'/exp OR prallethrin OR '2-methyl-4-oxo-3-(2-propynyl)cyclopent-2-enyl chrysanthemate' OR 'prallethrin' OR 'd,d-t80-prallethrin' OR 143 '23031-36-9':rn OR '103065-19-6':rn 144 'pyrethrum'/exp OR 'pyrethrum' OR 'pyrethrums' OR 'cinerin' OR 'cinerins' OR 'jasmolin' OR 'jasmolins' OR '8003-34-7':rn 145 'resmethrin'/exp OR 'resmethrin' OR 'chryson' OR 'sbp 1382' OR 'scourge' OR '10453-86-8':rn Online appendix C: Search terms for Embase

146 'silafluofen' OR 'salifluofen' OR '105024-66-6':rn 147 'tefluthrin'/exp OR 'tefluthrin' OR '79538-32-2':rn 'tetramethrin'/exp OR 'tetramethrin' OR '3, 4, 5, 6 tetrahydrophthalimidomethyl chrysanthemate' OR 'chrysanthemic acid 3, 4, 5, 6 148 tetrahydrophthalimidomethyl ester' OR 'lenpoucid' OR 'neopynamin' OR 'neopynamine' OR 'phthalthrin' OR 'sanpouxil' OR '7696-12-0':rn OR '66525-27-7':rn OR '5284-41-3':rn OR '52556-74-8':rn OR '1166-46-7':rn OR '51348-91-5':rn OR '51348-90-4':rn 149 'tralomethrin'/exp OR 'tralomethrin' OR '66841-25-6':rn OR '1375081-91-6':rn 150 'transfluthrin'/exp OR 'transfluthrin' OR '118712-89-3':rn 151 'neonicotinoid'/exp OR 'neonicotinoids' OR 'neonicotinoid' 152 'acetamiprid'/exp OR 'acetamiprid' OR 'td-2480' OR 'td-2472' OR '160430-64-8':rn OR '135410-20-7':rn 'clothianidin'/exp OR 'clothianidin' OR '((e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine)' OR 'ti-435' OR 'ti 435' OR '1 (2 chloro 153 1, 3 thiazol 5 ylmethyl) 3 methyl 2 nitroguanidine' OR '1 (2 chloro 5 thiazolylmethyl) 3 methyl 2 nitroguanidine' OR 'clothianidine' OR '210880- 92-5':rn 'dinotefuran'/ex OR 'dinotefuran' OR '1-methyl-2-nitro-3-((3-tetrahydrofuryl)methyl)guanidine' OR 'mti-446' OR 'mti 446' OR '2 methyl 1 nitro 3 154 (tetrahydrofurfuryl) guanidine' OR '165252-70-0':rn 'imidacloprid'/exp OR 'imidacloprid' OR '1 (6 chloro 3 pyridylmethyl) n nitroimidazolidin 2 ylideneamine' OR '1-((6-chloro-3-pyridinyl)methyl)-n- 155 nitro-2-imidazolidinimine' OR 'premise 75' OR '138261-41-3':rn OR '105827-78-9':rn 156 'nitenpyram'/exp OR 'nitenpyram' OR 'capstar' OR '120738-89-8':rn OR '150824-47-8':rn 'nithiazine'/exp OR 'nithiazine' OR 'tetrahydro-2-(nitromethylene)-2h-1,3-thiazine' OR 'ski-71' OR 'wl-35651' OR 'ls-192830' OR 'sd 35651' OR 'sd- 157 35651' OR 'tetrahydro 2 nitromethylene 2h 1, 3 thiazine' OR '58842-20-9':rn OR '97190-65-3':rn

158 'thiacloprid'/exp OR 'thiacloprid' OR 'thiaclopride' OR '3-((6-chloro-3-pyridinyl)methyl)-2-thiazolidinylidene cyanamide' OR '111988-49-9':rn 159 'thiamethoxam'/exp OR 'thiamethoxam' OR 'actara 25 WG' OR 'cga 293343' OR 'cga-293343' OR '153719-23-4':rn 160 'sulfoxaflor'/exp OR 'sulfoxaflor' OR '946578-00-3':rn 'flupyradifurone'/exp OR 'flupyradifurone' OR '4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan-2(5h)-one' OR 'sivanto' OR 161 '951659-40-8':rn 162 'triflumezopyrim' OR '1263133-33-0':rn 163 'spinosyn A'/exp OR 'spinosyn' OR 'spinosyns' OR 'a 83543a' OR 'a83543a' OR 'lepicidin A' 164 'spinetoram'/exp OR 'spinetoram' OR 'xde-175' OR '187166-15-0':rn OR '187166-40-1':rn 165 'spinosad'/exp OR 'spinosad' OR 'ly 232105' OR 'ly232105' OR 'natroba' OR '131929-63-0':rn OR '131929-60-7':rn 'avermectin'/exp OR 'avermectin B1 a'/exp OR 'milbemycin'/exp OR 'ivermectin'/exp OR 'milbemycin A'/exp OR 'moxidectin'/exp OR 166 'milbemycin D'/exp OR 'avermectin' OR 'avermectins' OR 'aversectin' OR 'aversectins' OR 'milbemycin' OR 'milbemycins' OR '5-o- demethylavermectin a1a' OR '22, 23 dihydroavermectin b1' OR 'milbemax' OR 'moxidectin' 167 'abamectin'/exp OR 'abamectin' OR 'vertimec' OR 'avermectin B1' OR 'enzec' OR '65195-55-3':rn OR '65195-56-4':rn 168 'emamectin benzoate'/exp OR 'emamectin benzoate' OR '155569-91-8':rn OR '138511-98-5':rn OR '138511-97-4':rn OR '155569-91-8':rn 169 'lepimectin' OR '1016160-53-4':rn 170 'milbemectin' OR '171249-05-1':rn OR '950999-51-6':rn 171 'pymetrozine'/exp OR 'pymetrozine' OR '123312-89-0':rn 172 'pyrifluquinazon' OR '337458-27-2':rn 173 'flonicamid'/exp OR 'flonicamid' OR 'n-cyanomethyl-4-trifluoromethylnicotinamide' OR 'carbine' OR '158062-67-0':rn 174 'bensultap'/exp OR 'bensultap' OR 'bancol' OR '17606-31-4':rn 175 'cartap'/exp OR 'cartap' OR 'padan' OR '15263-53-3':rn OR '15263-52-2':rn 176 'n, n-dimethyl-1,2,3-trithian-5-yl amine' OR 'thiocyclam' OR '31895-21-3':rn 177 'thiosultap' OR 'thosultap' OR 'molosultap' OR 'monomehypo' OR 'monosultap' OR 'bisultap' OR 'dimehypo' OR 'disosultap' OR '52207-48-4':rn

178 'amitraz'/exp OR 'amitraz' OR 'mitaban' OR 'taktic' OR 'n-methyl-bis(2,4-xylyiminomethyl) amine' OR 'u 36059' OR '33089-61-1':rn 'indoxacarb'/exp OR 'indoxacarb' OR 'activyl' OR 'dpx-mp062' OR 'dpx mp 062' OR 'dpx mp062' OR 'dpxmp 062' OR 'dpxmp062' OR '173584-44- 179 6':rn 180 'metaflumizone'/exp OR 'metaflumizone' OR '139968-49-3':rn OR '139970-56-2':rn 181 'chlorantraniliprole'/exp OR 'chlorantranilipole' OR 'chlorantraniliprole' OR 'dpx-e2y45' OR 'rynaxypyr' OR '500008-45-7':rn 182 'cyantraniliprole'/exp OR 'cyantraniliprole' OR '736994-63-1':rn 183 'flubendiamide'/exp OR 'flubendiamide' OR '272451-65-7':rn Online appendix C: Search terms for Embase

1 AND (2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31 OR 32 OR 33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 OR 45 OR 46 OR 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56 OR 57 OR 58 OR 59 OR 60 OR 61 OR 62 OR 63 OR 64 OR 65 OR 66 OR 67 OR 68 OR 69 OR 70 OR 71 OR 72 OR 73 OR 74 OR 75 OR 76 OR 77 OR 78 OR 79 OR 80 OR 81 OR 82 OR 83 OR 84 OR 85 OR 86 OR 87 OR 88 OR 89 OR 90 OR 91 OR 92 OR 93 OR 94 OR 95 OR 96 OR 97 OR 98 OR 99 OR 100 OR 101 OR 102 OR 103 OR 104 OR 105 OR 106 OR 107 OR 108 184 OR 109 OR 110 OR 111 OR 112 OR 113 OR 114 OR 115 OR 116 OR 117 OR 118 OR 119 OR 120 OR 121 OR 122 OR 123 OR 124 OR 125 OR 126 OR 127 OR 128 OR 129 OR 130 OR 131 OR 132 OR 133 OR 134 OR 135 OR 136 OR 137 OR 138 OR 139 OR 140 OR 141 OR 142 OR 143 OR 144 OR 145 OR 146 OR 147 OR 148 OR 149 OR 150 OR 151 OR 152 OR 153 OR 154 OR 155 OR 156 OR 157 OR 158 OR 159 OR 160 OR 161 OR 162 OR 163 OR 164 OR 165 OR 166 OR 167 OR 168 OR 169 OR 170 OR 171 OR 172 OR 173 OR 174 OR 175 OR 176 OR 177 OR 178 OR 179 OR 180 OR 181 OR 182 OR 183) Online appendix D: Search terms for Scopus

1 {diabetes} OR diabet* OR iddm OR niddm OR hyper-glycemi* OR hyper-glycaemi* OR hyperglycemi* OR hyperglycaemi* OR hyperglycosemi* OR hyperglycosaemi* OR {blood glucose} OR {blood sugar} OR {plasma glucose} OR {plasma sugar} OR {serum glucose} OR {serum sugar} OR {glucose homeostasis} OR {glucose homeostatic} OR {glucose regulation} OR dysglycem* OR dysglycaem* OR glycemi* OR glycaemi* OR glucosaemi* OR glucosemi* OR {glycated haemoglobin A1c} OR {Glycated Hemoglobin} OR {glycated hemoglobin A1c} OR {Glycated Hemoglobins} OR {Glycohemoglobin A} OR {glycosylated haemoglobin A1c} OR {Glycosylated Hemoglobin} OR {haemoglobin a (1c)} OR {haemoglobin a 1c} OR {haemoglobin A1c} OR {haemoglobin aic} OR {hb a (1c)} OR {Hb A1} OR {Hb A1a+b} OR {Hb A1c} OR {hba 1c} OR {HbA1} OR {hba1c} OR {hemoglobin a (1c)} OR {hemoglobin a 1c} OR {Hemoglobin A(1)} OR {Hemoglobin A, Glycated} OR {Hemoglobin A, Glycosylated} OR {Hemoglobin A1c, Glycated} OR {Hemoglobin A1c, Glycosylated} OR {hemoglobin aic} OR {Hemoglobin, Glycosylated} OR {Hemoglobins, Glycated} OR prediabet* OR pre-diabet* OR {impaired fasting glucose} OR {glucose intolerance} OR {glucose intolerant} OR {glucose tolerance} OR {ogtt} OR {glucose load} OR {glucose loading test} OR {glucose test} OR {insulin resistance} OR {insulin resistant} OR {insulin sensitivity} OR {insulin sensitive} OR {insulin insensitivity} OR {insulin insensitive} OR {metabolic syndrome} OR hyperinsuli* OR hyper-insuli* OR {insulin} OR {homeostasis model assessment} OR {homeostatic model assessment} OR {insulin test} OR hypoinsulin* OR hypo-insulin* OR {insulinopenia} OR {beta cell} OR {beta cells} OR {beta islet cell} OR {insulin producing cell} OR {insulin producing cells} OR {insulin secreting cell} OR {insulin secreting cells} OR {pancreas b cell} OR {pancreas beta islet cell} OR {pancreas islet b cell} OR {pancreatic b cell} OR {pancreatic islet b cell} OR {pancreatic islet b cell}

2 pesticid* 3 insecticid* 4 {carbamates} OR {carbamate} 5 {alanicarb} OR {alanycarb} 6 {aldicarb} OR {temik} OR {temick} 7 {aminocarb} OR {matacil} OR {4-dimethylamino-3-tolyl-N-methylcarbamate} 8 {bendiocarb} OR {ficam} 9 {benfuracarb} 10 {butocarboxim} 11 {butoxycarboxim} 12 {carbaryl} OR {carbaril} OR {carbyl} 13 {carbofuran} OR {furadan} 14 {carbosulfan} 15 {croneton} OR {ethiofencarb} OR {kroneton} 16 {BPMC} OR {fenobucarb} 17 {Fenothiocarb} 18 {fenoxycarb} OR {ethyl(2-(4-phenoxyphenoxy)ethyl)carbamate} 19 {formetanate} 20 {deltanit} OR {furathiocarb} OR {furatiocarb} 21 {1-isopropyl-3-methyl-5-pyrazolyldimethylcarbamate} OR {dimethylcarbamic acid 1 isopropyl 3 methyl 5 pyrazolyl ester} OR {1 isopropyl 3 methyl 5 pyrazolyl dimethylcarbamate} OR {1 isopropyl 3 methylpyrazol 5 yl dimethylcarbamate} OR {dimethylcarbamic acid 1 isopropyl 3 methylpyrazol 5 yl ester} OR {primin} OR {primine} 22 {isoprocarb} OR {phenyl-2-(1-methylethyl)methylcarbamate} OR {2-isopropylphenyl methylcarbamate} 23 {methiocarb} OR {mercaptodimethur} 24 {methomyl} OR {lannate} 25 {metolcarb} 26 {oxamyl} OR {vydate} 27 {pirimicarb} OR {pirimor} OR {pyrimor} OR {ZZ-Aphox} 28 {propoxur} OR {O-Isopropoxyphenylmethylcarbamate} OR {O Isopropoxyphenylmethylcarbamate} OR {Unden} OR {sendran} OR {aprocarb} 29 {thiodicarb} 30 {thiofanox} OR {dacamox} OR {thiofanocarb} 31 {triazamate} 32 {trimethacarb} OR {landrin} OR {landrina} 33 {xmc} OR {carbaron} OR {3,5-xylyl methylcarbamate} OR {3,5-dimethylphenyl methylcarbamate} OR {cosban} OR {maqbarl} OR {macbal} 34 {xylylcarb} 35 {organophosphates} OR {organophosphate} OR {organothiophosphates} OR {organothiophosphate} OR {organophosphorus} OR {organophosphorous} OR {organothiophosphorus} OR {organothiophosphorous} 36 {acephate} OR {O,S-dimethyl N-acetyl phosphoramidothioate} OR {orthene} 37 {amiton} OR {O,O-diethyl S-(diethylaminoethyl) phosphorothiolate} 38 {azamethiphos} 39 {azinphos ethyl} OR {azinphos-ethyl} OR {azinphosethyl} OR {ethyl azinphos} OR {ethyl-azinphos} OR {ethylazinphos} 40 {azinphosmethyl} OR {azinphos-methyl} OR {azinphos methyl} OR {methylazinphos} OR {methyl-azinphos} OR {methyl azinphos} OR {guthion} 41 {cadusafos} OR {O-ethyl, S-bis(1-methylpropyl)phosphorodithioate} Online appendix D: Search terms for Scopus

42 {chlorethoxyfos} 43 {chlorfenvinphos} OR {clofenvinfos} OR {chlorphenvinphos} OR {dermaton} OR {birlane} 44 {chlormephos} 45 {chlorpyrifos} OR {lorsban} OR {dursban} 46 {chlorpyrifos-methyl} OR {chlorpyrifos methyl} OR {chlorpyrifosmethyl} OR {methyl-chlorpyrifos} OR {methyl chlorpyrifos} OR {methylchlorpyrifos} OR {dowco 214} OR {reldan} 47 {coumaphos} OR {asuntol} 48 {crufomate} OR {ruelene} OR {ruerene} 49 {cyanophos} OR {cyanox} 50 {cyanophenphos} OR {cyanofenphos} OR {surecide} 51 {cythioate} OR {cyflee} 52 {demeton-S-methyl} OR {demeton s methyl} OR {S-2-ethylthioethyl-O,O-dimethylphosphorothiolate} 53 {diazinon} OR {dimpylate} OR {neocidol} OR {neotsidol} OR {bazudine} 54 {dichlorvos} OR {ddvp} OR {dichlofos} OR {dimethyl dichlorovinyl phosphate} OR {phosphoric acid 2,2-dichloroethenyl dimethyl ester} OR {phosphoric acid 2,2 dichloroethenyl dimethyl ester} OR {dichlorophos} OR {divipan} OR {novotox} OR {dichlorfos} OR {dichlorofos} OR {dichlorovos} OR {dichlorphos} 55 {dicrotophos} OR {carbicron} OR {bidrin} 56 {dimethoate} OR {phosphamide} OR {rogor} 57 {dimethylvinphos} 58 {disulfoton} OR {thiodemeton} OR {di-syston} OR {di syston} OR {disyston} OR {demeton} OR {thiometon ethyl} OR {thiometon-ethyl} OR {thiometonethyl} OR {ethyl thiometon} OR {ethyl-thiometon} OR {ethylthiometon} 59 {phenylphosphonothioic acid, 2-ethyl 2-(4-nitrophenyl) ester} OR {phenylphosphonothioic acid o ethyl o (4 nitrophenyl) ester} OR {O-Ethyl-O-(4- nitrophenyl)phenylphosphonothioate} OR {benzenephosphonothioic acid o ethyl o 4 nitrophenyl ester} OR {epn} OR {ethyl 4 nitrophenyl phenylphosphonothioate} OR {o (4 nitrophenyl) o ethyl phenylphosphonothioate} OR {o ethyl o (4 nitrophenyl) phenylthiophosphonate} OR {o ethyl o (4 nitrophenyl) phenylphosphonothioate} OR {o ethyl o 4 nitrophenyl benzenephosphonothioate} OR {o ethyl o 4 nitrophenyl benzenethiophosphonate} OR {o ethyl o 4 nitrophenyl phenylphosphonothioate} OR {o ethyl o 4 nitrophenyl phenylphosponothionate} OR {o ethyl o 4 nitrophenylphenylphosphonothioic acid} OR {o ethyl o para nitrophenyl phenylphosphonothioate} OR {o ethyl o para nitrophenyl phenylphosphonothionate} OR {o ethyl o para nitrophenyl phenylthiophosphonate} OR {phenylphosphonethioic acid o ethyl o para nitrophenyl ester} OR {phenylphosphonothioic acid ethyl 4 nitrophenyl ester} OR {phenylphosphonothioic acid o ethyl o 4 nitrophenyl ester} OR {phenylphosphonothioic acid o ethyl o para nitrophenyl ester} OR {phenylphosphonothioic acid, 2 ethyl 2 (4 nitrophenyl) ester} OR {phenylphosphonothioic acid, 2-ethyl 2- (4-nitrophenyl) ester} OR {phenylphosphonothioic acid, o-ethyl o- (4-nitrophenyl) ester}) NOT {emphysematous pyelonephritis}

60 {ethion} OR {diethion} OR {ethopaz} OR {nialate} OR {ethyl methylene phosphorodithioate} OR {diethion} 61 {ethoprophos} OR {ethoprop} OR {O-ethyl S,S-diprophyl phosphorodithioate} OR {mocap} OR {o ethyl s, s dipropyl phosphorodithioate} OR {o ethyl s, s dipropylphosphorodithioate} OR {phosphorodithioic acid o ethyl s, s dipropyl ester} OR {prophos} 62 {etrimfos} OR {ekamet} OR {o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioic acid o, o dimethyl ester} OR {o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioate} OR {o, o dimethyl o (6 ethoxy 2 ethylpyrimidin 4 yl) phosphorothioate} OR {phosphorothioic acid o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidinyl) ester} 63 {famophos} OR {O,O-dimethyl O-p-(dimethylsulfamoyl)phenylphosphorothioate} OR {famphur} OR {warbex} OR {varbex} 64 {fenamiphos} OR {ethyl 4-(methylthio)m-tolyl isopropylphosphoroamidate} OR {phenamiphos} OR {nemacur} 65 {fenitrothion} OR {metathion} OR {dolithion} OR {nitrophos} OR {sumithion} OR {sumithione} OR {accothion} OR {agrothion} OR {dimethyl (3 methyl para nitrophenyl) phosphorothioate} OR {fenitrotion} OR {fenthrothion} OR {fentrothion} OR {folithion} OR {nuvanol} OR {o, o dimethyl o (3 methyl 4 nitrophenyl) phosphorothioate} OR {o, o dimethyl o (3 methyl 4 nitrophenyl) thionophosphate} OR {o, o dimethyl o (3 methyl 4 nitrophenyl) thiophosphate} OR {o, o dimethyl o (3 methyl para nitrophenyl) phosphorothioate} OR {o, o dimethyl o (4 nitro 1, 3 tolyl) phosphorothioate} OR {o, o dimethyl o (para nitro meta tolyl) phosphorothioate} OR {o, o dimethyl o para nitro meta tolylphosphorothioate} OR {phenitrothion} 66 {fensulfothion} OR {(4 methylsulfinylphenyl) phosphorothioic acid diethyl ester} OR {dasanit} OR {dansit} OR {diethyl (4 methylsulfinylphenyl) phosphorothioate} OR {o, o diethyl o (4 methylsulfinyl) phosphorothioic acid} OR {o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate} OR {o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate} OR {o, o diethyl o (para methylsulfinylphenyl) phosphorothioate} OR {phosphorothioic acid o, o diethyl o (4 methylsulfinylphenyl) ester} OR {terracur} 67 {fenthion} OR {mercaptophos} OR {lebaycid} OR {4 methylmercapto 3 methylphenyl dimethyl thiophosphate} OR {dimethyl (3 methyl para methylthiophenyl) phosphorothioate} OR {dimethyl (4 methylthio) meta tolyl phosphorothioate} OR {entex} OR {fenthione} OR {o, o dimethyl o (3 methyl 4 methylthiophenyl) phosphorothioate} OR {o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate} OR {o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate} OR {o, o dimethyl o (3 methyl para methylthiophenyl) phosphorothioate} OR {o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate} OR {o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate} OR {o, o dimethyl o (4 methylthio 3 methylphenyl) thiophosphate} OR {queletox} OR {spotton} OR {tiguvon} Online appendix D: Search terms for Scopus

68 {fonofos} OR {dyfonate} OR {dyphonate} OR {ethylphosphonodithioic acid o ethyl s phenyl ester} OR {fonophos} OR {o ethyl s phenyl ethylphosphonodithioate} 69 {formothion} OR {anthio} OR {antio} OR {anfix} OR {s (n formyl n methylcarbamoylmethyl) o, o dimethyl phosphorodithioate} 70 {fosthiazate} OR {(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate} 71 {heptenophos} OR {hostaquick} OR {ragadan} 72 {imicyafos} 73 {isofenphos} OR {isophenphos} OR {isopropylphosphoramidothioic acid o ethyl o 2 isopropoxycarbonylphenyl ester} OR {o ethyl o 2 isopropoxycarbonylphenyl isopropylphosphoramidothioate} OR {oftanol} 74 {isocarbophos} OR {O-2-isopropoxycarbonylphenyl O-methyl phosphoramidothioate} 75 {isoxathion} 76 {leptophos} OR {phosvel} OR {o (2, 5 dichloro 4 bromophenyl) o methylphenylthiophosphonate} OR {phenylphosphonothioic acid o (4 bromo 2, 5 dichlorophenyl) o methyl ester} 77 {malaoxon} OR {malathion oxon} 78 {karbofos} OR {carbophos} OR {carbafos} OR {carbofos} OR {prioderm} OR {sadophos} OR {cythion} OR {derbac m} OR {fosfotion} OR {fyfanon} OR {kypfos} OR {lusap} OR {malathione} OR {malathon} OR {malthion} OR {malthione} OR {nalathion} OR {o, o dimethyl dithiophosphate of diethyl mercaptosuccinate} OR {o, o dimethyldithiophosphate derivative of diethyl succinate} OR {organoderm} OR {ovide} OR {phosphothion} OR {prioderm} OR {(1, 2 dicarbethoxyethyl) o, o dimethyl phosphorodithioate} OR {s (1, 2 dicarbethoxyethyl) o, o dimethyldithiophosphate} OR {sadofos} OR {zithiol} OR {maldison} OR {mercaptothion} 79 {mecarbam} OR {S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl)-O,O-diethylphosphorodithioate} OR {Murfatox} 80 {methacrifos} 81 {methamidophos} OR {O,S-dimethylphosphoroamidothioate} OR {metamidophos} OR {tamaron} 82 {methidathion} OR {metidathion} OR {Supracide} 83 {mevinphos} OR {fosdrin} OR {phosdrin} OR {fosdrine} OR {(1 carbomethoxy) 1 propen 2 yl dimethyl phosphate} OR {(2 carbomethoxy 1 methylvinyl) dimethyl phosphate} OR {(carbomethoxypropen 2 yl) dimethyl phosphate} OR {(carbomethoxypropen 2 yl) dimethyl phosphate} OR {(carbomethoxypropen 2 yl) dimethylphosphate} OR {1 carbomethoxy 1 propen 2 yl dimethyl phosphate} OR {1 carbomethoxy 1 propen 2 yl dimethylphosphate} OR {1 carbomethoxy 1 propen 2 yldimethyl phosphate} 84 {mipafox} OR {bis (isopropylamino) fluorophosphine oxide} OR {isopestox} 85 {monocrotophos} OR {nuvacron} OR {azodrin} OR {3 (dimethoxyphosphinoyloxy) n methyl cis crotonamide} OR {3 (dimethoxyphosphinyloxy) n methyl cis crotonamide} OR {3 (dimethoxyphosphinyloxy) n methylcrotonamide} OR {3 [(dimethoxyphosphinoyl) oxy] n methyl cis crotonamide} 86 {naled} OR {1, 2 dibromo 2, 2 dichloroethyl dimethyl phosphate} OR {1, 2 dibromo 2, 2 dichloroethyl dimethylphosphate} OR {1, 2 dibromo 2, 2 dichloroethyldimethyl phosphate} OR {alvora} OR {bromex} OR {dibrom} OR {o, o dimethyl o (1, 2 dibromo 2, 2 dichloroethyl) phosphate} OR {phosphoric acid (1, 2 dibromo 2, 2 dichloroethyl) dimethyl ester} OR {phosphoric acid 1, 2 dibromo 2, 2 dichloroethyl dimethyl ester} OR {bromchlophos} 87 {dimethoxon} OR {omethoate} OR {o-methoate} OR {folimat} OR {o, o dimethyl s (n methylcarbamoylmethyl) phosphorothioate} OR {phosphorothioic acid o, o dimethyl s (n methylcarbamoylmethyl) ester} 88 {methyl demeton} OR {methyl-demeton} OR {oxydemeton methyl} OR {oxydemeton-methyl} OR {oxydemeton methyl} OR {oxydemeton- methyl} OR {oxydemetonmethyl} OR {methyl oxydemeton} OR {methyl-oxydemeton} OR {methyloxydemeton} OR {demeton-methyl} OR {O,O- dimethyl S-(2-(ethylsulfinyl)ethyl)phosphorothioate} OR {metasystox} OR {methylmercaptophos oxide} 89 {alkron} OR {aphamite} OR {corthion} OR {diethyl nitrophenyl thiophosphate} OR {diethyl p nitrophenyl monothiophosphate} OR {diethylparathion} OR {dimethyl para nitrophenolthiophosphate} OR {ecatox} OR {ekatox} OR {ethyl parathion} OR {ethylparathion} OR {etilon} OR {folidol} OR {isoparathion} OR {niran} OR {nitrostigmine} OR {o, o diethyl o (4 nitrophenyl) phosphorothioate} OR {o, o diethyl o (4 nitrophenyl) thiophosphate} OR {o, o diethyl o (para nitrophenyl) phosphorothioate} OR {o, o diethyl o p nitrophenyl phosphorothioate} OR {paraphos} OR {parathion} OR {phosphemol} OR {phosphorothioic acid o, o diethyl o (4 nitrophenyl) ester} OR {phosphostigmine} OR {thiophos} OR {tiofos} 90 {methyl parathion} OR {methyl-parathion} OR {methylparathion} OR {parathion methyl} OR {parathionmethyl} OR {parathion-methyl} OR {demethylfenitrothion} OR {dimethyl para nitrophenyl phosphorothioate} OR {dimethyl para nitrophenylphosphorothioate} OR {dimethyl (para nitrophenyl) phosphorothioate} OR {dimethylnitrophenylthiophosphate} OR {dimethylparathion} OR {fenitrothion, demethyl} OR {metaphos} OR {norfenitrothion} OR {o, o dimethyl o (para nitrophenyl) phosphorothioate} OR {o, o dimethyl o (para nitrophenyl) thiophosphate} OR {o, o dimethyl o (para nitrophenyl) phosphorothioate} OR {o, o dimethyl o (para nitrophenyl) phosphorothionate} OR {o, o dimethyl o para nitrophenyl phosphorothioate} OR {o, o dimethyl para nitrophenyl phosphorothioate} OR {phosphorothioic acid o, o dimethyl o (4 nitrophenyl) ester} OR {vofatox} OR {vophatox} OR {wofatox} OR {dalf} OR {metaphos}

91 {phenthoate} OR {elsan} OR {phendal} OR {cidial} OR {cidiale} OR {dimethenthoate} OR {fenthoate} OR {phosphorodithioic acid s (alpha carbethoxybenzyl) o, o dimethyl ester} OR {s alpha ethoxycarbonylbenzyl o, o dimethyl phosphorodithioate} OR {tannone} OR {o,o-dimethyl S- alpha-ethoxycarbonylbenzylphosphorodithioate} Online appendix D: Search terms for Scopus

92 {phorate} OR {diethyl ethylthiomethyl phosphorodithioate} OR {l 11 6} OR {o, o diethyl s (ethylthiomethyl) phosphorodithioate} OR {o, o diethyl s (ethylthiomethyl) phosphorodithioate} OR {phorates} OR {phosphorodithioic acid o, o diethyl s [(ethylthio) methyl] ester} OR {thimet} OR {timet} 93 {phosalone} OR {phozalone} OR {phoazlone} OR {fozalone} OR {fosalone} OR {fosalon} OR {o, o diethyl s (6 chloro 2 oxobenzoxazolin 3 ylmethyl) phosphorodithioate} OR {s (6 chloro 2 oxobenzoxazolin 3 yl) methyl diethyl phosphorothiolothioate} OR {zolone} OR {benzophosphate} 94 {phosmet} OR {fosmet} OR {imidan} OR {n (mercaptomethyl) phthalimide s (o, o dimethyl) phosphorodithioate} OR {n (mercaptomethyl) phthalimide s (o, o dimethylphosphorodithioate)} OR {o, o dimethyl s (phthalimidomethyl) phosphorodithioate} OR {o, o dimethyl s phthalimidomethyl phosphorodithioate} OR {phosphorodithioic acid o, o dimethyl s phthalimidomethyl ester} OR {porect} OR {phthalophos} 95 {phosphamidon} OR {2 chloro n, n diethyl 3 hydroxycrotonamide dimethyl phosphate} OR {dimecron} OR {dimethyl (2 chloro 1 diethylaminocroton 3 yl) phosphate} OR {liromidon} OR {o, o dimethyl o (2 chloro 1 diethylaminocroton 3 yl) phosphate} 96 {phoxim} OR {phenylglyoxylonitrile oxime o,o-diethylphosphorothioate} OR {valekson} OR {valexon} OR {sebacil} OR {foxim} OR {o (alpha cyanobenzylideneamino) o, o diethyl phosphorothioate} OR {o, o diethyl o (alpha cyanobenzylideneamino) phosphorothioate} OR {phenylglyoxylonitrile oxime o, o diethylphosphorothioate} OR {volaton} 97 {pirimiphos methyl} OR {pirimiphosmethyl} OR {pirimiphos-methyl} OR {methyl-pirimiphos} OR {methyl pirimiphos} OR {methylpirimiphos} OR {o-(2-(diethylamino)-6-methyl-4-pyrimidinyl) o,o- dimethylphosphorothioate lic} OR {piritione} OR {actellic} OR {aktel} 98 {profenofos} OR {curacron} OR {selecron} OR {o (4 bromo 2 chlorophenyl) o ethyl s propyl phosphorothioate} OR {phosphorothioic acid o (4 bromo 2 chlorophenyl) o ethyl s propyl ester} 99 {propetamphos} 100 {prothiophos} OR {prothiofos} OR {tokuthion} OR {tukuthion} 101 {pyraclofos} OR {o-(1-(4-chlorophenyl)-4-pyrazolyl) o-ethyl S-propyl phosphorothioate} 102 {pyridafenthion} OR {o,o-diethyl o-(3-oxo-2-phenyl-2H-pyridazin-6- yl) phosphorothioate} OR {pyridaphenthion} OR {ofunack} OR {o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) phosphorothioate} OR {phosphorothioic acid o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) ester} OR {pyridaphenthione} 103 {quinalphos} OR {diethylquinalphione} OR {o,o-diethyl-o-(quinoxalinyl-(2))thionophosphate} OR {o,o-diethyl-o-(quinoxalyl)phosphorothioate} OR {o, o diethyl o (2 quinoxalinyl) phosphorothioate} OR {phosphorothioic acid o, o diethyl o (2 quinoxalinyl) ester} OR {bayrusil} OR {ekalux} OR {bayer 77049} 104 {sulfotepp} OR {sulfotep} OR {ethyl thiopyrophosphate} OR {asymmetric tetraethyl dithiopyrophosphate} 105 {tebupirimphos} 106 {temefos} OR {temephos} OR {difos} OR {abathion} 107 {terbufos} OR {o,o-diethyl s((tert-butylthio)methyl)phosphorodithioate} OR {o, o diethyl s (tert butylthio) methylphosphorodithioate} 108 {tetrachlorvinphos} OR {stirofos} OR {gardona} OR {rabon} OR {2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethylphosphate} OR {2 chloro 1 (2, 4, 5 trichlorophenyl) vinyldimethylphosphate} OR {phosphoric acid 2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethyl ester} OR {stirophos} OR {tetrachlorofenvinphos} 109 {thiometon} OR {ekatin} OR {intration} OR {aasystem} OR {duphar dimeaat} OR {ecatin} OR {intrathion} OR {intrathione} OR {luxan} OR {o, o dimethyl s (2 ethylthioethyl) phosphorodithioate} OR {o, o dimethyl s (2 ethylthioethyl) phosphorodithioate} OR {o, o dimethyl s ethylthioethyl phosphorodithioate} OR {sysmeton} 110 {triazophos} OR {1-phenyl-3-(o,o-diethylthiophosphoryl)-1,2,4- triazole} OR {hostathion} OR {o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) phosphorothioate} OR {phosphorothioic acid o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) ester} 111 {merphos} OR {tributyl phosphorotrithioite} OR {s,s,s-tributyl phosphorotrithioite} OR {folex} OR {tributyl-phosphorotrithioite} OR {tributylphosphorotrithioite} OR {phosphorotrithioite tributyl} OR {phosphorotrithioite-tributyl} OR {phosphorotrithioitetributyl} 112 {chlorophos} OR {chlorofos} OR {metrifonate} OR {dipterex} OR {dylox} OR {neguvon} OR {ricifon} OR {bilarcil} OR {bilacil} OR {bilharcil} OR {foschlor} OR {2, 2, 2 trichloro 1 hydroxyethylphosphonic acid dimethyl ester} OR {bay a 9826} OR {bay a9826} OR {bayer 15922} OR {bayer 2349} OR {bayer l 13-59} OR {bayer l 1359} OR {bayer l13-59} OR {bayer l1359} OR {combot} OR {dimethyl (2, 2, 2 trichloro 1 hydroxyethyl) phosphonate} OR {dyrex} OR {dyvon} OR {etfoschlor} OR {flibol e} OR {masoten} OR {metriphonate} OR {metrifonate} OR {metrofinate} OR {o, o dimethyl 1 hydroxy 2, 2, 2 trichloroethylphosphonate} OR {o, o dimethyl 2, 2, 2 trichloro 1 hydroxyethylphosphonate} OR {o, o dimethyl (1 hydroxy 2, 2, 2 trichlorethyl) phosphonate} OR {promem} OR {promen} OR {trichlorfon} OR {trichlorofon} OR {trichlorophon} OR {trichlorophone} OR {trichlorphon} OR {trichlorphone} OR {tugon} OR {dipterex} 113 {o,o-dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl)phosphorothioate} OR {kilval} OR {vamidothion} 114 {fiproles} OR {fiprole} 115 {ethiprole} 116 {fipronil} OR {fiprex} 117 {pyrethrin} OR {pyrethrins} OR {pyrethroid} OR {pyrethroids} OR {ipevet} OR {ipevetex} OR {pyrethrasin} 118 {acrinathrin} 119 {allethrin} OR {allethrins} OR {3 allyl 2 methyl 4 oxo 2 cyclopenten 1 yl chrysanthemate} OR {3 allyl 2 methyl 4 oxo 2 cyclopentenyl chrysanthemate} OR {allethrine} OR {allyl cinerin} OR {allethroxyl d, l cis, trans chrysanthemate} OR {pynamin} OR {pyresyn} Online appendix D: Search terms for Scopus

120 {bifenthrin} OR {bifenthrine} OR {fmc 54800} OR {fmc54800} OR {talstar} 121 {bioallethrin} OR {allethrin, bio} OR {s-bioallethrin} OR {d-trans-allethrin} 122 {bioresmethrin} OR {trans-resmethrin} OR {ru 11484} OR {d-trans-resmethrin} 123 {cismethrin} OR {5-benzyl-3-furylmethyl(1.R)-cis-chrysanthemate} OR {NRDC 119} OR {cis (+) resmethrin} OR {methrin, cis} OR {resmethrin, cis (+)} 124 {cycloprothrin} 125 {cyfluthrin} OR {oms 2012} OR {oms-2012} OR {beta-cyfluthrin} OR {beta cyfluthrin} OR {bay fcr 1272} OR {bay fcr1272} OR {baythroid} OR {baytroid} OR {ciflutrin} OR {cyfloxylate} OR {fcr 1272} OR {fcr1272} 126 {cyhalothrin} OR {lambda-cyhalothrin} OR {lambdacyhalothrin} OR {pp 321} OR {oms 3021} OR {oms-3021} OR {gamma cyhalothrin} OR {gamma- cyhalothrin} OR {gammacyhalothrin} 127 {2 (2, 2 dichlorovinyl) 3, 3 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester} OR {3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester} OR {3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid meta phenoxymandelonitrile ester} OR {alfa cypermethrin} OR {alfa methrin} OR {alfa methrine} OR {alfacypermethrin} OR {alfamethrin} OR {alfamethrine} OR {alpha cyano 3 phenoxybenzyl 3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylate} OR {alpha cypermethrin} OR {alpha cypermethrine} OR {alpha-cypermethrin} OR {alphacypermethrin} OR {alpha methrin} OR {alpha methrine} OR {alphacypermethrin} OR {alphamethrin} OR {alphamethrine} OR {barricade} OR {beta cypermethrine} OR {beta cypermethrin} OR {beta-cypermethrin} OR {betacypermethrin} OR {ccn 52} OR {ccn52} OR {cipermethrin} OR {cis cypermethrin} OR {cypermethrine} OR {cypermetrin} OR {flectron} OR {fmc 30980} OR {fmc30980} OR {nrdc 149} OR {nrdc 182} OR {nrdc149} OR {nrdc182} OR {wl 43467} OR {wl 85871} OR {wl43467} OR {wl85871} OR {supermethrin} OR {supercypermethrin} OR {cymbush} OR {fastac 50EC} OR {fendona} OR {beta-cipermetrina} OR {theta cypermethrin} OR {theta-cypermethrin} OR {thetacypermethrin} OR {zeta cypermethrin} OR {zeta-cypermethrin} OR {zetacypermethrin}

128 {cyphenothrin} OR {cis-cyphenothrin} OR {alpha cyano 3 phenoxybenzyl chrysanthemate} OR {chrysanthemic acid alpha cyano 3 phenoxybenzyl ester} 129 {decamethrin} OR {deltamethrin} OR {butox} OR {oms 1998} OR {difexon} OR {k-othrin} OR {nrdc 161} OR {decis} OR {deltanil} OR {k othrine} OR {pediculosane} 130 {empenthrin} OR {1-ethynyl-2-methyl-2-pentenyl chrysanthemate} OR {s 2852f} OR {s-2852f} OR {vaporthrin} OR {d-empenthrin} 131 {esfenvalerate} 132 {ethofenprox} OR {2-(4-ethoxyphenyl)-2-methylpropyl-3-phenoxybenzyl ether} OR {etofenprox} OR {Trebon} 133 {fenpropathrin} OR {(alpha cyano 3 phenoxybenzyl) 2, 2, 3, 3 tetramethylcyclopropanecarboxylate} OR {2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid (alpha cyano 3 phenoxybenzyl) ester} OR {2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester} OR {alpha cyano 3 phenoxybenzyl 2, 2, 3, 3 tetramethylcyclopropanecarboxylate} OR {fenpropanate} OR {meothrin} 134 {fenvalarate} OR {(alpha cyano 3 phenoxybenzyl) 2 (4 chlorophenyl) 3 methylbutyrate} OR {2 (4 chlorophenyl) 3 methylbutyric acid (alpha cyano 3 phenoxybenzyl) ester} OR {2 (4 chlorophenyl) isovaleric acid alpha cyano 3 phenoxybenzyl ester} OR {3 phenoxymandelonitrile 2 (4 chlorophenyl) 2 isopropylacetate} OR {alpha cyano 3 phenoxybenzyl alpha isopropyl 4 chlorophenylacetate} OR {alpha isopropyl 4 chlorophenylacetic acid alpha cyano 3 phenoxybenzyl ester} OR {arkofly} OR {belmark} OR {cyano (3 phenoxyphenyl) methyl 4 chloro alpha (1 methylethyl) benzeneacetate} OR {ectrin} OR {phenvalerate} OR {pidrin} OR {pydrin} OR {pyrethroid sd 43775} OR {s 5602} OR {s-5602} OR {sd 43775} OR {sumicidin} OR {wl 43775} OR {sumi-alpha} OR {belmark} OR {alpha-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3- methylbutyrate} OR {alpha-cyano-3-phenoxybenzyl alpha-isopropyl-4-chlorophenyl acetate} 135 {flucythrinate} OR {(alpha cyano 3 phenoxybenzyl) 4 difluoromethoxy alpha isopropylphenylacetate} OR {4 difluoromethoxy alpha isopropylphenylacetic acid alpha cyano 3 phenoxybenzyl ester} OR {ac 222, 705} OR {ac 222705} OR {ac222, 705} OR {ac222705} OR {cyano (3 phenoxyphenyl) methyl 4 (difluoromethoxy) alpha (1 methylethyl) benzeneacetate} 136 {flumethrin} OR {bayticol} 137 {fluvalinate} OR {tau-fluvalinate} OR {tau fluvalinate} OR {taufluvalinate} OR {mavrik} 138 {halfenprox} OR {brofenprox} 139 {imiprothrin} 140 {kadethrin} 141 {permethrin} OR {cis-permethrin} OR {cis permethrin} OR {cispermethrin} OR {cis-(1rs)-permethrin} OR {trans-permethrin} OR {trans permethrin} OR {transpermethrin} OR {trans-(1rs)-permethrin} OR {pp-557} OR {pp 557} OR {pp557} OR {s-3151} OR {s 3151} OR {s3151} OR {elimite} OR {fmc-33297} OR {fmc 33297} OR {fmc33297} OR {nia-33297} OR {nia 33297} OR {nia33297} OR {nittifor} OR {nrdc-143} OR {nrdc 143} OR {nrdc143} OR {nrdc-147} OR {nrdc 147} OR {nrdc147} OR {acticin} OR {armol} OR {atroban} OR {dronol} OR {ectiban} OR {ectomethrin} OR {expar} OR {gamabenceno plus} OR {gamaderm} OR {infectopedicul} OR {klinits} OR {loxazol} OR {lyclear} OR {mite-x} OR {nedax plus} OR {new- nok} OR {novo-herklin 2000} OR {oms 1821} OR {perigen} OR {permanone} OR {permectrin} OR {permicren} OR {permite} OR {piopel} OR {quellada-p} OR {scabmite} OR {stockade} OR {stockate} OR {wl 43479} OR {zehu-ze}

142 {d-phenothrin} OR {phenothrin} OR {sumithrin} OR {s-2539} OR {3 phenoxybenzyl chrysanthemate} OR {chrysanthemic acid 3 phenoxybenzyl ester} OR {fenothrin} OR {sumithrin} 143 {2-methyl-4-oxo-3-(2-propynyl)cyclopent-2-enyl chrysanthemate} OR {prallethrin} OR {d,d-t80-prallethrin} 144 {pyrethrum} OR {pyrethrums} OR {cinerin} OR {cinerins} OR {jasmolin} OR {jasmolins} Online appendix D: Search terms for Scopus

145 {resmethrin} OR {chryson} OR {sbp 1382} OR {scourge} 146 {silafluofen} OR {salifluofen} 147 {tefluthrin} 148 {tetramethrin} OR {3, 4, 5, 6 tetrahydrophthalimidomethyl chrysanthemate} OR {chrysanthemic acid 3, 4, 5, 6 tetrahydrophthalimidomethyl ester} OR {lenpoucid} OR {neopynamin} OR {neopynamine} OR {phthalthrin} OR {sanpouxil} 149 {tralomethrin} 150 {transfluthrin} 151 {neonicotinoids} OR {neonicotinoid} 152 {acetamiprid} OR {td-2480} OR {td-2472} 153 {clothianidin} OR {((e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine)} OR {ti-435} OR {ti 435} OR {1 (2 chloro 1, 3 thiazol 5 ylmethyl) 3 methyl 2 nitroguanidine} OR {1 (2 chloro 5 thiazolylmethyl) 3 methyl 2 nitroguanidine} OR {clothianidine} 154 {dinotefuran} OR {1-methyl-2-nitro-3-((3-tetrahydrofuryl)methyl)guanidine} OR {mti-446} OR {mti 446} OR {2 methyl 1 nitro 3 (tetrahydrofurfuryl) guanidine} 155 {imidacloprid} OR {1 (6 chloro 3 pyridylmethyl) n nitroimidazolidin 2 ylideneamine} OR {1-((6-chloro-3-pyridinyl)methyl)-n-nitro-2- imidazolidinimine} OR {premise 75} 156 {nitenpyram} OR {capstar} 157 {nithiazine} OR {tetrahydro-2-(nitromethylene)-2h-1,3-thiazine} OR {ski-71} OR {wl-35651} OR {ls-192830} OR {sd 35651} OR {sd-35651} OR {tetrahydro 2 nitromethylene 2h 1, 3 thiazine} 158 {thiacloprid} OR {thiaclopride} OR {3-((6-chloro-3-pyridinyl)methyl)-2-thiazolidinylidene cyanamide} 159 {thiamethoxam} OR {actara 25 WG} OR {cga 293343} OR {cga-293343} 160 {sulfoxaflor} 161 {flupyradifurone} OR {4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan-2(5h)-one} OR {sivanto} 162 {triflumezopyrim} 163 {spinosyn} OR {spinosyns} OR {a 83543a} OR {a83543a} OR {lepicidin A} 164 {spinetoram} OR {xde-175} 165 {spinosad} OR {ly 232105} OR {ly232105} OR {natroba} 166 {avermectin} OR {avermectins} OR {aversectin} OR {aversectins} OR {milbemycin} OR {milbemycins} OR {5-o-demethylavermectin a1a} OR {22, 23 dihydroavermectin b1} OR {milbemax} OR {moxidectin} 167 {abamectin} OR {vertimec} OR {avermectin B1} OR {enzec} 168 {emamectin benzoate} 169 {lepimectin} 170 {milbemectin} 171 {pymetrozine} 172 {pyrifluquinazon} 173 {flonicamid} OR {n-cyanomethyl-4-trifluoromethylnicotinamide} OR {carbine} 174 {bensultap} OR {bancol} 175 {cartap} OR {padan} 176 {n, n-dimethyl-1,2,3-trithian-5-yl amine} OR {thiocyclam} 177 {thiosultap} OR {thosultap} OR {molosultap} OR {monomehypo} OR {monosultap} OR {bisultap} OR {dimehypo} OR {disosultap} 178 {amitraz} OR {mitaban} OR {taktic} OR {n-methyl-bis(2,4-xylyiminomethyl) amine} OR {u 36059} 179 {indoxacarb} OR {activyl} OR {dpx-mp062} OR {dpx mp 062} OR {dpx mp062} OR {dpxmp 062} OR {dpxmp062} 180 {metaflumizone} 181 {chlorantranilipole} OR {chlorantraniliprole} OR {dpx-e2y45} OR {rynaxypyr} 182 {cyantraniliprole} 183 {flubendiamide} 184 1 AND (2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31 OR 32 OR 33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 OR 45 OR 46 OR 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56 OR 57 OR 58 OR 59 OR 60 OR 61 OR 62 OR 63 OR 64 OR 65 OR 66 OR 67 OR 68 OR 69 OR 70 OR 71 OR 72 OR 73 OR 74 OR 75 OR 76 OR 77 OR 78 OR 79 OR 80 OR 81 OR 82 OR 83 OR 84 OR 85 OR 86 OR 87 OR 88 OR 89 OR 90 OR 91 OR 92 OR 93 OR 94 OR 95 OR 96 OR 97 OR 98 OR 99 OR 100 OR 101 OR 102 OR 103 OR 104 OR 105 OR 106 OR 107 OR 108 OR 109 OR 110 OR 111 OR 112 OR 113 OR 114 OR 115 OR 116 OR 117 OR 118 OR 119 OR 120 OR 121 OR 122 OR 123 OR 124 OR 125 OR 126 OR 127 OR 128 OR 129 OR 130 OR 131 OR 132 OR 133 OR 134 OR 135 OR 136 OR 137 OR 138 OR 139 OR 140 OR 141 OR 142 OR 143 OR 144 OR 145 OR 146 OR 147 OR 148 OR 149 OR 150 OR 151 OR 152 OR 153 OR 154 OR 155 OR 156 OR 157 OR 158 OR 159 OR 160 OR 161 OR 162 OR 163 OR 164 OR 165 OR 166 OR 167 OR 168 OR 169 OR 170 OR 171 OR 172 OR 173 OR 174 OR 175 OR 176 OR 177 OR 178 OR 179 OR 180 OR 181 OR 182 OR 183) Online appendix E: Search terms for Web of Science

1 "diabetes" OR diabet* OR iddm OR niddm OR hyper-glycemi* OR hyper-glycaemi* OR hyperglycemi* OR hyperglycaemi* OR hyperglycosemi* OR hyperglycosaemi* OR "blood glucose" OR "blood sugar" OR "plasma glucose" OR "plasma sugar" OR "serum glucose" OR "serum sugar" OR "glucose homeostasis" OR "glucose homeostatic" OR "glucose regulation" OR dysglycem* OR dysglycaem* OR glycemi* OR glycaemi* OR glucosaemi* OR glucosemi* OR "glycated haemoglobin A1c" OR "Glycated Hemoglobin" OR "glycated hemoglobin A1c" OR "Glycated Hemoglobins" OR "Glycohemoglobin A" OR "glycosylated haemoglobin A1c" OR "Glycosylated Hemoglobin" OR "haemoglobin a (1c)" OR "haemoglobin a 1c" OR "haemoglobin A1c" OR "haemoglobin aic" OR "hb a (1c)" OR "Hb A1" OR "Hb A1a+b" OR "Hb A1c" OR "hba 1c" OR "HbA1" OR "hba1c" OR "hemoglobin a (1c)" OR "hemoglobin a 1c" OR "Hemoglobin A(1)" OR "Hemoglobin A, Glycated" OR "Hemoglobin A, Glycosylated" OR "Hemoglobin A1c, Glycated" OR "Hemoglobin A1c, Glycosylated" OR "hemoglobin aic" OR "Hemoglobin, Glycosylated" OR "Hemoglobins, Glycated" OR prediabet* OR pre-diabet* OR "impaired fasting glucose" OR "glucose intolerance" OR "glucose intolerant" OR "glucose tolerance" OR "ogtt" OR "glucose load" OR "glucose loading test" OR "glucose test" OR "insulin resistance" OR "insulin resistant" OR "insulin sensitivity" OR "insulin sensitive" OR "insulin insensitivity" OR "insulin insensitive" OR "metabolic syndrome" OR hyperinsuli* OR hyper- insuli* OR "insulin" OR "homeostasis model assessment" OR "homeostatic model assessment" OR "insulin test" OR hypoinsulin* OR hypo- insulin* OR "insulinopenia" OR "beta cell" OR "beta cells" OR "beta islet cell" OR "insulin producing cell" OR "insulin producing cells" OR "insulin secreting cell" OR "insulin secreting cells" OR "pancreas b cell" OR "pancreas beta islet cell" OR "pancreas islet b cell" OR "pancreatic b cell" OR "pancreatic islet b cell" OR "pancreatic islet b cell"

2 pesticid* 3 insecticid* 4 "carbamates" OR "carbamate" 5 "alanicarb" OR "alanycarb" 6 "aldicarb" OR "temik" OR "temick" 7 "aminocarb" OR "matacil" OR "4-dimethylamino-3-tolyl-N-methylcarbamate" 8 "bendiocarb" OR "ficam" 9 "benfuracarb" 10 "butocarboxim" 11 "butoxycarboxim" 12 "carbaryl" OR "carbaril" OR "carbyl" 13 "carbofuran" OR "furadan" 14 "carbosulfan" 15 "croneton" OR "ethiofencarb" OR "kroneton" 16 "BPMC" OR "fenobucarb" 17 "Fenothiocarb" 18 "fenoxycarb" OR "ethyl(2-(4-phenoxyphenoxy)ethyl)carbamate" 19 "formetanate" 20 "deltanit" OR "furathiocarb" OR "furatiocarb" 21 "1-isopropyl-3-methyl-5-pyrazolyldimethylcarbamate" OR "dimethylcarbamic acid 1 isopropyl 3 methyl 5 pyrazolyl ester" OR "1 isopropyl 3 methyl 5 pyrazolyl dimethylcarbamate" OR "1 isopropyl 3 methylpyrazol 5 yl dimethylcarbamate" OR "dimethylcarbamic acid 1 isopropyl 3 methylpyrazol 5 yl ester" OR "primin" OR "primine" 22 "isoprocarb" OR "phenyl-2-(1-methylethyl)methylcarbamate" OR "2-isopropylphenyl methylcarbamate" 23 "methiocarb" OR "mercaptodimethur" 24 "methomyl" OR "lannate" 25 "metolcarb" 26 "oxamyl" OR "vydate" 27 "pirimicarb" OR "pirimor" OR "pyrimor" OR "ZZ-Aphox" 28 "propoxur" OR "O-Isopropoxyphenylmethylcarbamate" OR "O Isopropoxyphenylmethylcarbamate" OR "Unden" OR "sendran" OR "aprocarb" 29 "thiodicarb" 30 "thiofanox" OR "dacamox" OR "thiofanocarb" 31 "triazamate" 32 "trimethacarb" OR "landrin" OR "landrina" 33 "xmc" OR "carbaron" OR "3,5-xylyl methylcarbamate" OR "3,5-dimethylphenyl methylcarbamate" OR "cosban" OR "maqbarl" OR "macbal" 34 "xylylcarb" 35 "organophosphates" OR "organophosphate" OR "organothiophosphates" OR "organothiophosphate" OR "organophosphorus" OR "organophosphorous" OR "organothiophosphorus" OR "organothiophosphorous" 36 "acephate" OR "O,S-dimethyl N-acetyl phosphoramidothioate" OR "orthene" 37 "amiton" OR "O,O-diethyl S-(diethylaminoethyl) phosphorothiolate" 38 "azamethiphos" 39 "azinphos ethyl" OR "azinphos-ethyl" OR "azinphosethyl" OR "ethyl azinphos" OR "ethyl-azinphos" OR "ethylazinphos" 40 "azinphosmethyl" OR "azinphos-methyl" OR "azinphos methyl" OR "methylazinphos" OR "methyl-azinphos" OR "methyl azinphos" OR "guthion" Online appendix E: Search terms for Web of Science

41 "cadusafos" OR "O-ethyl, S-bis(1-methylpropyl)phosphorodithioate" 42 "chlorethoxyfos" 43 "chlorfenvinphos" OR "clofenvinfos" OR "chlorphenvinphos" OR "dermaton" OR "birlane" 44 "chlormephos" 45 "chlorpyrifos" OR "lorsban" OR "dursban" 46 "chlorpyrifos-methyl" OR "chlorpyrifos methyl" OR "chlorpyrifosmethyl" OR "methyl-chlorpyrifos" OR "methyl chlorpyrifos" OR "methylchlorpyrifos" OR "dowco 214" OR "reldan" 47 "coumaphos" OR "asuntol" 48 "crufomate" OR "ruelene" OR "ruerene" 49 "cyanophos" OR "cyanox" 50 "cyanophenphos" OR "cyanofenphos" OR "surecide" 51 "cythioate" OR "cyflee" 52 "demeton-S-methyl" OR "demeton s methyl" OR "S-2-ethylthioethyl-O,O-dimethylphosphorothiolate" 53 "diazinon" OR "dimpylate" OR "neocidol" OR "neotsidol" OR "bazudine" 54 "dichlorvos" OR "ddvp" OR "dichlofos" OR "dimethyl dichlorovinyl phosphate" OR "phosphoric acid 2,2-dichloroethenyl dimethyl ester" OR "phosphoric acid 2,2 dichloroethenyl dimethyl ester" OR "dichlorophos" OR "divipan" OR "novotox" OR "dichlorfos" OR "dichlorofos" OR "dichlorovos" OR "dichlorphos" 55 "dicrotophos" OR "carbicron" OR "bidrin" 56 "dimethoate" OR "phosphamide" OR "rogor" 57 "dimethylvinphos" 58 "disulfoton" OR "thiodemeton" OR "di-syston" OR "di syston" OR "disyston" OR "demeton" OR "thiometon ethyl" OR "thiometon-ethyl" OR "thiometonethyl" OR "ethyl thiometon" OR "ethyl-thiometon" OR "ethylthiometon" 59 "phenylphosphonothioic acid, 2-ethyl 2-(4-nitrophenyl) ester" OR "phenylphosphonothioic acid o ethyl o (4 nitrophenyl) ester" OR "O-Ethyl-O- (4-nitrophenyl)phenylphosphonothioate" OR "benzenephosphonothioic acid o ethyl o 4 nitrophenyl ester" OR "epn" OR "ethyl 4 nitrophenyl phenylphosphonothioate" OR "o (4 nitrophenyl) o ethyl phenylphosphonothioate" OR "o ethyl o (4 nitrophenyl) phenylthiophosphonate" OR "o ethyl o (4 nitrophenyl) phenylphosphonothioate" OR "o ethyl o 4 nitrophenyl benzenephosphonothioate" OR "o ethyl o 4 nitrophenyl benzenethiophosphonate" OR "o ethyl o 4 nitrophenyl phenylphosphonothioate" OR "o ethyl o 4 nitrophenyl phenylphosponothionate" OR "o ethyl o 4 nitrophenylphenylphosphonothioic acid" OR "o ethyl o para nitrophenyl phenylphosphonothioate" OR "o ethyl o para nitrophenyl phenylphosphonothionate" OR "o ethyl o para nitrophenyl phenylthiophosphonate" OR "phenylphosphonethioic acid o ethyl o para nitrophenyl ester" OR "phenylphosphonothioic acid ethyl 4 nitrophenyl ester" OR "phenylphosphonothioic acid o ethyl o 4 nitrophenyl ester" OR "phenylphosphonothioic acid o ethyl o para nitrophenyl ester" OR "phenylphosphonothioic acid, 2 ethyl 2 (4 nitrophenyl) ester" OR "phenylphosphonothioic acid, 2-ethyl 2- (4-nitrophenyl) ester" OR "phenylphosphonothioic acid, o-ethyl o- (4-nitrophenyl) ester") NOT "emphysematous pyelonephritis"

60 "ethion" OR "diethion" OR "ethopaz" OR "nialate" OR "ethyl methylene phosphorodithioate" OR "diethion" 61 "ethoprophos" OR "ethoprop" OR "O-ethyl S,S-diprophyl phosphorodithioate" OR "mocap" OR "o ethyl s, s dipropyl phosphorodithioate" OR "o ethyl s, s dipropylphosphorodithioate" OR "phosphorodithioic acid o ethyl s, s dipropyl ester" OR "prophos" 62 "etrimfos" OR "ekamet" OR "o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioic acid o, o dimethyl ester" OR "o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioate" OR "o, o dimethyl o (6 ethoxy 2 ethylpyrimidin 4 yl) phosphorothioate" OR "phosphorothioic acid o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidinyl) ester" 63 "famophos" OR "O,O-dimethyl O-p-(dimethylsulfamoyl)phenylphosphorothioate" OR "famphur" OR "warbex" OR "varbex" 64 "fenamiphos" OR "ethyl 4-(methylthio)m-tolyl isopropylphosphoroamidate" OR "phenamiphos" OR "nemacur" 65 "fenitrothion" OR "metathion" OR "dolithion" OR "nitrophos" OR "sumithion" OR "sumithione" OR "accothion" OR "agrothion" OR "dimethyl (3 methyl para nitrophenyl) phosphorothioate" OR "fenitrotion" OR "fenthrothion" OR "fentrothion" OR "folithion" OR "nuvanol" OR "o, o dimethyl o (3 methyl 4 nitrophenyl) phosphorothioate" OR "o, o dimethyl o (3 methyl 4 nitrophenyl) thionophosphate" OR "o, o dimethyl o (3 methyl 4 nitrophenyl) thiophosphate" OR "o, o dimethyl o (3 methyl para nitrophenyl) phosphorothioate" OR "o, o dimethyl o (4 nitro 1, 3 tolyl) phosphorothioate" OR "o, o dimethyl o (para nitro meta tolyl) phosphorothioate" OR "o, o dimethyl o para nitro meta tolylphosphorothioate" OR "phenitrothion" 66 "fensulfothion" OR "(4 methylsulfinylphenyl) phosphorothioic acid diethyl ester" OR "dasanit" OR "dansit" OR "diethyl (4 methylsulfinylphenyl) phosphorothioate" OR "o, o diethyl o (4 methylsulfinyl) phosphorothioic acid" OR "o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate" OR "o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate" OR "o, o diethyl o (para methylsulfinylphenyl) phosphorothioate" OR "phosphorothioic acid o, o diethyl o (4 methylsulfinylphenyl) ester" OR "terracur" Online appendix E: Search terms for Web of Science

67 "fenthion" OR "mercaptophos" OR "lebaycid" OR "4 methylmercapto 3 methylphenyl dimethyl thiophosphate" OR "dimethyl (3 methyl para methylthiophenyl) phosphorothioate" OR "dimethyl (4 methylthio) meta tolyl phosphorothioate" OR "entex" OR "fenthione" OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) phosphorothioate" OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate" OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate" OR "o, o dimethyl o (3 methyl para methylthiophenyl) phosphorothioate" OR "o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate" OR "o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate" OR "o, o dimethyl o (4 methylthio 3 methylphenyl) thiophosphate" OR "queletox" OR "spotton" OR "tiguvon"

68 "fonofos" OR "dyfonate" OR "dyphonate" OR "ethylphosphonodithioic acid o ethyl s phenyl ester" OR "fonophos" OR "o ethyl s phenyl ethylphosphonodithioate" 69 "formothion" OR "anthio" OR "antio" OR "anfix" OR "s (n formyl n methylcarbamoylmethyl) o, o dimethyl phosphorodithioate" 70 "fosthiazate" OR "(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate" 71 "heptenophos" OR "hostaquick" OR "ragadan" 72 "imicyafos" 73 "isofenphos" OR "isophenphos" OR "isopropylphosphoramidothioic acid o ethyl o 2 isopropoxycarbonylphenyl ester" OR "o ethyl o 2 isopropoxycarbonylphenyl isopropylphosphoramidothioate" OR "oftanol" 74 "isocarbophos" OR "O-2-isopropoxycarbonylphenyl O-methyl phosphoramidothioate" 75 "isoxathion" 76 "leptophos" OR "phosvel" OR "o (2, 5 dichloro 4 bromophenyl) o methylphenylthiophosphonate" OR "phenylphosphonothioic acid o (4 bromo 2, 5 dichlorophenyl) o methyl ester" 77 "malaoxon" OR "malathion oxon" 78 "karbofos" OR "carbophos" OR "carbafos" OR "carbofos" OR "prioderm" OR "sadophos" OR "cythion" OR "derbac m" OR "fosfotion" OR "fyfanon" OR "kypfos" OR "lusap" OR "malathione" OR "malathon" OR "malthion" OR "malthione" OR "nalathion" OR "o, o dimethyl dithiophosphate of diethyl mercaptosuccinate" OR "o, o dimethyldithiophosphate derivative of diethyl succinate" OR "organoderm" OR "ovide" OR "phosphothion" OR "prioderm" OR "(1, 2 dicarbethoxyethyl) o, o dimethyl phosphorodithioate" OR "s (1, 2 dicarbethoxyethyl) o, o dimethyldithiophosphate" OR "sadofos" OR "zithiol" OR "maldison" OR "mercaptothion" 79 "mecarbam" OR "S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl)-O,O-diethylphosphorodithioate" OR "Murfatox" 80 "methacrifos" 81 "methamidophos" OR "O,S-dimethylphosphoroamidothioate" OR "metamidophos" OR "tamaron" 82 "methidathion" OR "metidathion" OR "Supracide" 83 "mevinphos" OR "fosdrin" OR "phosdrin" OR "fosdrine" OR "(1 carbomethoxy) 1 propen 2 yl dimethyl phosphate" OR "(2 carbomethoxy 1 methylvinyl) dimethyl phosphate" OR "(carbomethoxypropen 2 yl) dimethyl phosphate" OR "(carbomethoxypropen 2 yl) dimethyl phosphate" OR "(carbomethoxypropen 2 yl) dimethylphosphate" OR "1 carbomethoxy 1 propen 2 yl dimethyl phosphate" OR "1 carbomethoxy 1 propen 2 yl dimethylphosphate" OR "1 carbomethoxy 1 propen 2 yldimethyl phosphate" 84 "mipafox" OR "bis (isopropylamino) fluorophosphine oxide" OR "isopestox" 85 "monocrotophos" OR "nuvacron" OR "azodrin" OR "3 (dimethoxyphosphinoyloxy) n methyl cis crotonamide" OR "3 (dimethoxyphosphinyloxy) n methyl cis crotonamide" OR "3 (dimethoxyphosphinyloxy) n methylcrotonamide" OR "3 [(dimethoxyphosphinoyl) oxy] n methyl cis crotonamide" 86 "naled" OR "1, 2 dibromo 2, 2 dichloroethyl dimethyl phosphate" OR "1, 2 dibromo 2, 2 dichloroethyl dimethylphosphate" OR "1, 2 dibromo 2, 2 dichloroethyldimethyl phosphate" OR "alvora" OR "bromex" OR "dibrom" OR "o, o dimethyl o (1, 2 dibromo 2, 2 dichloroethyl) phosphate" OR "phosphoric acid (1, 2 dibromo 2, 2 dichloroethyl) dimethyl ester" OR "phosphoric acid 1, 2 dibromo 2, 2 dichloroethyl dimethyl ester" OR "bromchlophos" 87 "dimethoxon" OR "omethoate" OR "o-methoate" OR "folimat" OR "o, o dimethyl s (n methylcarbamoylmethyl) phosphorothioate" OR "phosphorothioic acid o, o dimethyl s (n methylcarbamoylmethyl) ester" 88 "methyl demeton" OR "methyl-demeton" OR "oxydemeton methyl" OR "oxydemeton-methyl" OR "oxydemeton methyl" OR "oxydemeton- methyl" OR "oxydemetonmethyl" OR "methyl oxydemeton" OR "methyl-oxydemeton" OR "methyloxydemeton" OR "demeton-methyl" OR "O,O- dimethyl S-(2-(ethylsulfinyl)ethyl)phosphorothioate" OR "metasystox" OR "methylmercaptophos oxide" 89 "alkron" OR "aphamite" OR "corthion" OR "diethyl nitrophenyl thiophosphate" OR "diethyl p nitrophenyl monothiophosphate" OR "diethylparathion" OR "dimethyl para nitrophenolthiophosphate" OR "ecatox" OR "ekatox" OR "ethyl parathion" OR "ethylparathion" OR "etilon" OR "folidol" OR "isoparathion" OR "niran" OR "nitrostigmine" OR "o, o diethyl o (4 nitrophenyl) phosphorothioate" OR "o, o diethyl o (4 nitrophenyl) thiophosphate" OR "o, o diethyl o (para nitrophenyl) phosphorothioate" OR "o, o diethyl o p nitrophenyl phosphorothioate" OR "paraphos" OR "parathion" OR "phosphemol" OR "phosphorothioic acid o, o diethyl o (4 nitrophenyl) ester" OR "phosphostigmine" OR "thiophos" OR "tiofos" Online appendix E: Search terms for Web of Science

90 "methyl parathion" OR "methyl-parathion" OR "methylparathion" OR "parathion methyl" OR "parathionmethyl" OR "parathion-methyl" OR "demethylfenitrothion" OR "dimethyl para nitrophenyl phosphorothioate" OR "dimethyl para nitrophenylphosphorothioate" OR "dimethyl (para nitrophenyl) phosphorothioate" OR "dimethylnitrophenylthiophosphate" OR "dimethylparathion" OR "fenitrothion, demethyl" OR "metaphos" OR "norfenitrothion" OR "o, o dimethyl o (para nitrophenyl) phosphorothioate" OR "o, o dimethyl o (para nitrophenyl) thiophosphate" OR "o, o dimethyl o (para nitrophenyl) phosphorothioate" OR "o, o dimethyl o (para nitrophenyl) phosphorothionate" OR "o, o dimethyl o para nitrophenyl phosphorothioate" OR "o, o dimethyl para nitrophenyl phosphorothioate" OR "phosphorothioic acid o, o dimethyl o (4 nitrophenyl) ester" OR "vofatox" OR "vophatox" OR "wofatox" OR "dalf" OR "metaphos"

91 "phenthoate" OR "elsan" OR "phendal" OR "cidial" OR "cidiale" OR "dimethenthoate" OR "fenthoate" OR "phosphorodithioic acid s (alpha carbethoxybenzyl) o, o dimethyl ester" OR "s alpha ethoxycarbonylbenzyl o, o dimethyl phosphorodithioate" OR "tannone" OR "o,o-dimethyl S- alpha-ethoxycarbonylbenzylphosphorodithioate" 92 "phorate" OR "diethyl ethylthiomethyl phosphorodithioate" OR "l 11 6" OR "o, o diethyl s (ethylthiomethyl) phosphorodithioate" OR "o, o diethyl s (ethylthiomethyl) phosphorodithioate" OR "phorates" OR "phosphorodithioic acid o, o diethyl s [(ethylthio) methyl] ester" OR "thimet" OR "timet" 93 "phosalone" OR "phozalone" OR "phoazlone" OR "fozalone" OR "fosalone" OR "fosalon" OR "o, o diethyl s (6 chloro 2 oxobenzoxazolin 3 ylmethyl) phosphorodithioate" OR "s (6 chloro 2 oxobenzoxazolin 3 yl) methyl diethyl phosphorothiolothioate" OR "zolone" OR "benzophosphate" 94 "phosmet" OR "fosmet" OR "imidan" OR "n (mercaptomethyl) phthalimide s (o, o dimethyl) phosphorodithioate" OR "n (mercaptomethyl) phthalimide s (o, o dimethylphosphorodithioate)" OR "o, o dimethyl s (phthalimidomethyl) phosphorodithioate" OR "o, o dimethyl s phthalimidomethyl phosphorodithioate" OR "phosphorodithioic acid o, o dimethyl s phthalimidomethyl ester" OR "porect" OR "phthalophos" 95 "phosphamidon" OR "2 chloro n, n diethyl 3 hydroxycrotonamide dimethyl phosphate" OR "dimecron" OR "dimethyl (2 chloro 1 diethylaminocroton 3 yl) phosphate" OR "liromidon" OR "o, o dimethyl o (2 chloro 1 diethylaminocroton 3 yl) phosphate" 96 "phoxim" OR "phenylglyoxylonitrile oxime o,o-diethylphosphorothioate" OR "valekson" OR "valexon" OR "sebacil" OR "foxim" OR "o (alpha cyanobenzylideneamino) o, o diethyl phosphorothioate" OR "o, o diethyl o (alpha cyanobenzylideneamino) phosphorothioate" OR "phenylglyoxylonitrile oxime o, o diethylphosphorothioate" OR "volaton" 97 "pirimiphos methyl" OR "pirimiphosmethyl" OR "pirimiphos-methyl" OR "methyl-pirimiphos" OR "methyl pirimiphos" OR "methylpirimiphos" OR "o-(2-(diethylamino)-6-methyl-4-pyrimidinyl) o,o- dimethylphosphorothioate lic" OR "piritione" OR "actellic" OR "aktel" 98 "profenofos" OR "curacron" OR "selecron" OR "o (4 bromo 2 chlorophenyl) o ethyl s propyl phosphorothioate" OR "phosphorothioic acid o (4 bromo 2 chlorophenyl) o ethyl s propyl ester" 99 "propetamphos" 100 "prothiophos" OR "prothiofos" OR "tokuthion" OR "tukuthion" 101 "pyraclofos" OR "o-(1-(4-chlorophenyl)-4-pyrazolyl) o-ethyl S-propyl phosphorothioate" 102 "pyridafenthion" OR "o,o-diethyl o-(3-oxo-2-phenyl-2H-pyridazin-6- yl) phosphorothioate" OR "pyridaphenthion" OR "ofunack" OR "o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) phosphorothioate" OR "phosphorothioic acid o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) ester" OR "pyridaphenthione" 103 "quinalphos" OR "diethylquinalphione" OR "o,o-diethyl-o-(quinoxalinyl-(2))thionophosphate" OR "o,o-diethyl-o-(quinoxalyl)phosphorothioate" OR "o, o diethyl o (2 quinoxalinyl) phosphorothioate" OR "phosphorothioic acid o, o diethyl o (2 quinoxalinyl) ester" OR "bayrusil" OR "ekalux" OR "bayer 77049" 104 "sulfotepp" OR "sulfotep" OR "ethyl thiopyrophosphate" OR "asymmetric tetraethyl dithiopyrophosphate" 105 "tebupirimphos" 106 "temefos" OR "temephos" OR "difos" OR "abathion" 107 "terbufos" OR "o,o-diethyl s((tert-butylthio)methyl)phosphorodithioate" OR "o, o diethyl s (tert butylthio) methylphosphorodithioate" 108 "tetrachlorvinphos" OR "stirofos" OR "gardona" OR "rabon" OR "2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethylphosphate" OR "2 chloro 1 (2, 4, 5 trichlorophenyl) vinyldimethylphosphate" OR "phosphoric acid 2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethyl ester" OR "stirophos" OR "tetrachlorofenvinphos" 109 "thiometon" OR "ekatin" OR "intration" OR "aasystem" OR "duphar dimeaat" OR "ecatin" OR "intrathion" OR "intrathione" OR "luxan" OR "o, o dimethyl s (2 ethylthioethyl) phosphorodithioate" OR "o, o dimethyl s (2 ethylthioethyl) phosphorodithioate" OR "o, o dimethyl s ethylthioethyl phosphorodithioate" OR "sysmeton" 110 "triazophos" OR "1-phenyl-3-(o,o-diethylthiophosphoryl)-1,2,4- triazole" OR "hostathion" OR "o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) phosphorothioate" OR "phosphorothioic acid o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) ester" 111 "merphos" OR "tributyl phosphorotrithioite" OR "s,s,s-tributyl phosphorotrithioite" OR "folex" OR "tributyl-phosphorotrithioite" OR "tributylphosphorotrithioite" OR "phosphorotrithioite tributyl" OR "phosphorotrithioite-tributyl" OR "phosphorotrithioitetributyl" Online appendix E: Search terms for Web of Science

112 "chlorophos" OR "chlorofos" OR "metrifonate" OR "dipterex" OR "dylox" OR "neguvon" OR "ricifon" OR "bilarcil" OR "bilacil" OR "bilharcil" OR "foschlor" OR "2, 2, 2 trichloro 1 hydroxyethylphosphonic acid dimethyl ester" OR "bay a 9826" OR "bay a9826" OR "bayer 15922" OR "bayer 2349" OR "bayer l 13-59" OR "bayer l 1359" OR "bayer l13-59" OR "bayer l1359" OR "combot" OR "dimethyl (2, 2, 2 trichloro 1 hydroxyethyl) phosphonate" OR "dyrex" OR "dyvon" OR "etfoschlor" OR "flibol e" OR "masoten" OR "metriphonate" OR "metrifonate" OR "metrofinate" OR "o, o dimethyl 1 hydroxy 2, 2, 2 trichloroethylphosphonate" OR "o, o dimethyl 2, 2, 2 trichloro 1 hydroxyethylphosphonate" OR "o, o dimethyl (1 hydroxy 2, 2, 2 trichlorethyl) phosphonate" OR "promem" OR "promen" OR "trichlorfon" OR "trichlorofon" OR "trichlorophon" OR "trichlorophone" OR "trichlorphon" OR "trichlorphone" OR "tugon" OR "dipterex" 113 "o,o-dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl)phosphorothioate" OR "kilval" OR "vamidothion" 114 "fiproles" OR "fiprole" 115 "ethiprole" 116 "fipronil" OR "fiprex" 117 "pyrethrin" OR "pyrethrins" OR "pyrethroid" OR "pyrethroids" OR "ipevet" OR "ipevetex" OR "pyrethrasin" 118 "acrinathrin" 119 "allethrin" OR "allethrins" OR "3 allyl 2 methyl 4 oxo 2 cyclopenten 1 yl chrysanthemate" OR "3 allyl 2 methyl 4 oxo 2 cyclopentenyl chrysanthemate" OR "allethrine" OR "allyl cinerin" OR "allethroxyl d, l cis, trans chrysanthemate" OR "pynamin" OR "pyresyn" 120 "bifenthrin" OR "bifenthrine" OR "fmc 54800" OR "fmc54800" OR "talstar" 121 "bioallethrin" OR "allethrin, bio" OR "s-bioallethrin" OR "d-trans-allethrin" 122 "bioresmethrin" OR "trans-resmethrin" OR "ru 11484" OR "d-trans-resmethrin" 123 "cismethrin" OR "5-benzyl-3-furylmethyl(1.R)-cis-chrysanthemate" OR "NRDC 119" OR "cis (+) resmethrin" OR "methrin, cis" OR "resmethrin, cis (+)" 124 "cycloprothrin" 125 "cyfluthrin" OR "oms 2012" OR "oms-2012" OR "beta-cyfluthrin" OR "beta cyfluthrin" OR "bay fcr 1272" OR "bay fcr1272" OR "baythroid" OR "baytroid" OR "ciflutrin" OR "cyfloxylate" OR "fcr 1272" OR "fcr1272" 126 "cyhalothrin" OR "lambda-cyhalothrin" OR "lambdacyhalothrin" OR "pp 321" OR "oms 3021" OR "oms-3021" OR "gamma cyhalothrin" OR "gamma-cyhalothrin" OR "gammacyhalothrin" 127 "2 (2, 2 dichlorovinyl) 3, 3 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester" OR "3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester" OR "3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid meta phenoxymandelonitrile ester" OR "alfa cypermethrin" OR "alfa methrin" OR "alfa methrine" OR "alfacypermethrin" OR "alfamethrin" OR "alfamethrine" OR "alpha cyano 3 phenoxybenzyl 3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylate" OR "alpha cypermethrin" OR "alpha cypermethrine" OR "alpha-cypermethrin" OR "alphacypermethrin" OR "alpha methrin" OR "alpha methrine" OR "alphacypermethrin" OR "alphamethrin" OR "alphamethrine" OR "barricade" OR "beta cypermethrine" OR "beta cypermethrin" OR "beta-cypermethrin" OR "betacypermethrin" OR "ccn 52" OR "ccn52" OR "cipermethrin" OR "cis cypermethrin" OR "cypermethrine" OR "cypermetrin" OR "flectron" OR "fmc 30980" OR "fmc30980" OR "nrdc 149" OR "nrdc 182" OR "nrdc149" OR "nrdc182" OR "wl 43467" OR "wl 85871" OR "wl43467" OR "wl85871" OR "supermethrin" OR "supercypermethrin" OR "cymbush" OR "fastac 50EC" OR "fendona" OR "beta-cipermetrina" OR "theta cypermethrin" OR "theta-cypermethrin" OR "thetacypermethrin" OR "zeta cypermethrin" OR "zeta-cypermethrin" OR "zetacypermethrin"

128 "cyphenothrin" OR "cis-cyphenothrin" OR "alpha cyano 3 phenoxybenzyl chrysanthemate" OR "chrysanthemic acid alpha cyano 3 phenoxybenzyl ester" 129 "decamethrin" OR "deltamethrin" OR "butox" OR "oms 1998" OR "difexon" OR "k-othrin" OR "nrdc 161" OR "decis" OR "deltanil" OR "k othrine" OR "pediculosane" 130 "empenthrin" OR "1-ethynyl-2-methyl-2-pentenyl chrysanthemate" OR "s 2852f" OR "s-2852f" OR "vaporthrin" OR "d-empenthrin" 131 "esfenvalerate" 132 "ethofenprox" OR "2-(4-ethoxyphenyl)-2-methylpropyl-3-phenoxybenzyl ether" OR "etofenprox" OR "Trebon" 133 "fenpropathrin" OR "(alpha cyano 3 phenoxybenzyl) 2, 2, 3, 3 tetramethylcyclopropanecarboxylate" OR "2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid (alpha cyano 3 phenoxybenzyl) ester" OR "2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester" OR "alpha cyano 3 phenoxybenzyl 2, 2, 3, 3 tetramethylcyclopropanecarboxylate" OR "fenpropanate" OR "meothrin" 134 "fenvalarate" OR "(alpha cyano 3 phenoxybenzyl) 2 (4 chlorophenyl) 3 methylbutyrate" OR "2 (4 chlorophenyl) 3 methylbutyric acid (alpha cyano 3 phenoxybenzyl) ester" OR "2 (4 chlorophenyl) isovaleric acid alpha cyano 3 phenoxybenzyl ester" OR "3 phenoxymandelonitrile 2 (4 chlorophenyl) 2 isopropylacetate" OR "alpha cyano 3 phenoxybenzyl alpha isopropyl 4 chlorophenylacetate" OR "alpha isopropyl 4 chlorophenylacetic acid alpha cyano 3 phenoxybenzyl ester" OR "arkofly" OR "belmark" OR "cyano (3 phenoxyphenyl) methyl 4 chloro alpha (1 methylethyl) benzeneacetate" OR "ectrin" OR "phenvalerate" OR "pidrin" OR "pydrin" OR "pyrethroid sd 43775" OR "s 5602" OR "s-5602" OR "sd 43775" OR "sumicidin" OR "wl 43775" OR "sumi-alpha" OR "belmark" OR "alpha-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3- methylbutyrate" OR "alpha-cyano-3-phenoxybenzyl alpha-isopropyl-4-chlorophenyl acetate" 135 "flucythrinate" OR "(alpha cyano 3 phenoxybenzyl) 4 difluoromethoxy alpha isopropylphenylacetate" OR "4 difluoromethoxy alpha isopropylphenylacetic acid alpha cyano 3 phenoxybenzyl ester" OR "ac 222, 705" OR "ac 222705" OR "ac222, 705" OR "ac222705" OR "cyano (3 phenoxyphenyl) methyl 4 (difluoromethoxy) alpha (1 methylethyl) benzeneacetate" Online appendix E: Search terms for Web of Science

136 "flumethrin" OR "bayticol" 137 "fluvalinate" OR "tau-fluvalinate" OR "tau fluvalinate" OR "taufluvalinate" OR "mavrik" 138 "halfenprox" OR "brofenprox" 139 "imiprothrin" 140 "kadethrin" 141 "permethrin" OR "cis-permethrin" OR "cis permethrin" OR "cispermethrin" OR "cis-(1rs)-permethrin" OR "trans-permethrin" OR "trans permethrin" OR "transpermethrin" OR "trans-(1rs)-permethrin" OR "pp-557" OR "pp 557" OR "pp557" OR "s-3151" OR "s 3151" OR "s3151" OR "elimite" OR "fmc-33297" OR "fmc 33297" OR "fmc33297" OR "nia-33297" OR "nia 33297" OR "nia33297" OR "nittifor" OR "nrdc-143" OR "nrdc 143" OR "nrdc143" OR "nrdc-147" OR "nrdc 147" OR "nrdc147" OR "acticin" OR "armol" OR "atroban" OR "dronol" OR "ectiban" OR "ectomethrin" OR "expar" OR "gamabenceno plus" OR "gamaderm" OR "infectopedicul" OR "klinits" OR "loxazol" OR "lyclear" OR "mite-x" OR "nedax plus" OR "new-nok" OR "novo-herklin 2000" OR "oms 1821" OR "perigen" OR "permanone" OR "permectrin" OR "permicren" OR "permite" OR "piopel" OR "quellada-p" OR "scabmite" OR "stockade" OR "stockate" OR "wl 43479" OR "zehu-ze"

142 "d-phenothrin" OR "phenothrin" OR "sumithrin" OR "s-2539" OR "3 phenoxybenzyl chrysanthemate" OR "chrysanthemic acid 3 phenoxybenzyl ester" OR "fenothrin" OR "sumithrin" 143 "2-methyl-4-oxo-3-(2-propynyl)cyclopent-2-enyl chrysanthemate" OR "prallethrin" OR "d,d-t80-prallethrin" 144 "pyrethrum" OR "pyrethrums" OR "cinerin" OR "cinerins" OR "jasmolin" OR "jasmolins" 145 "resmethrin" OR "chryson" OR "sbp 1382" OR "scourge" 146 "silafluofen" OR "salifluofen" 147 "tefluthrin" 148 "tetramethrin" OR "3, 4, 5, 6 tetrahydrophthalimidomethyl chrysanthemate" OR "chrysanthemic acid 3, 4, 5, 6 tetrahydrophthalimidomethyl ester" OR "lenpoucid" OR "neopynamin" OR "neopynamine" OR "phthalthrin" OR "sanpouxil" 149 "tralomethrin" 150 "transfluthrin" 151 "neonicotinoids" OR "neonicotinoid" 152 "acetamiprid" OR "td-2480" OR "td-2472" 153 "clothianidin" OR "((e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine)" OR "ti-435" OR "ti 435" OR "1 (2 chloro 1, 3 thiazol 5 ylmethyl) 3 methyl 2 nitroguanidine" OR "1 (2 chloro 5 thiazolylmethyl) 3 methyl 2 nitroguanidine" OR "clothianidine" 154 "dinotefuran" OR "1-methyl-2-nitro-3-((3-tetrahydrofuryl)methyl)guanidine" OR "mti-446" OR "mti 446" OR "2 methyl 1 nitro 3 (tetrahydrofurfuryl) guanidine" 155 "imidacloprid" OR "1 (6 chloro 3 pyridylmethyl) n nitroimidazolidin 2 ylideneamine" OR "1-((6-chloro-3-pyridinyl)methyl)-n-nitro-2- imidazolidinimine" OR "premise 75" 156 "nitenpyram" OR "capstar" 157 "nithiazine" OR "tetrahydro-2-(nitromethylene)-2h-1,3-thiazine" OR "ski-71" OR "wl-35651" OR "ls-192830" OR "sd 35651" OR "sd-35651" OR "tetrahydro 2 nitromethylene 2h 1, 3 thiazine" 158 "thiacloprid" OR "thiaclopride" OR "3-((6-chloro-3-pyridinyl)methyl)-2-thiazolidinylidene cyanamide" 159 "thiamethoxam" OR "actara 25 WG" OR "cga 293343" OR "cga-293343" 160 "sulfoxaflor" 161 "flupyradifurone" OR "4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan-2(5h)-one" OR "sivanto" 162 "triflumezopyrim" 163 "spinosyn" OR "spinosyns" OR "a 83543a" OR "a83543a" OR "lepicidin A" 164 "spinetoram" OR "xde-175" 165 "spinosad" OR "ly 232105" OR "ly232105" OR "natroba" 166 "avermectin" OR "avermectins" OR "aversectin" OR "aversectins" OR "milbemycin" OR "milbemycins" OR "5-o-demethylavermectin a1a" OR "22, 23 dihydroavermectin b1" OR "milbemax" OR "moxidectin" 167 "abamectin" OR "vertimec" OR "avermectin B1" OR "enzec" 168 "emamectin benzoate" 169 "lepimectin" 170 "milbemectin" 171 "pymetrozine" 172 "pyrifluquinazon" 173 "flonicamid" OR "n-cyanomethyl-4-trifluoromethylnicotinamide" OR "carbine" 174 "bensultap" OR "bancol" 175 "cartap" OR "padan" 176 "n, n-dimethyl-1,2,3-trithian-5-yl amine" OR "thiocyclam" 177 "thiosultap" OR "thosultap" OR "molosultap" OR "monomehypo" OR "monosultap" OR "bisultap" OR "dimehypo" OR "disosultap" 178 "amitraz" OR "mitaban" OR "taktic" OR "n-methyl-bis(2,4-xylyiminomethyl) amine" OR "u 36059" 179 "indoxacarb" OR "activyl" OR "dpx-mp062" OR "dpx mp 062" OR "dpx mp062" OR "dpxmp 062" OR "dpxmp062" 180 "metaflumizone" 181 "chlorantranilipole" OR "chlorantraniliprole" OR "dpx-e2y45" OR "rynaxypyr" Online appendix E: Search terms for Web of Science

182 "cyantraniliprole" 183 "flubendiamide" 184 1 AND (2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31 OR 32 OR 33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 OR 45 OR 46 OR 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56 OR 57 OR 58 OR 59 OR 60 OR 61 OR 62 OR 63 OR 64 OR 65 OR 66 OR 67 OR 68 OR 69 OR 70 OR 71 OR 72 OR 73 OR 74 OR 75 OR 76 OR 77 OR 78 OR 79 OR 80 OR 81 OR 82 OR 83 OR 84 OR 85 OR 86 OR 87 OR 88 OR 89 OR 90 OR 91 OR 92 OR 93 OR 94 OR 95 OR 96 OR 97 OR 98 OR 99 OR 100 OR 101 OR 102 OR 103 OR 104 OR 105 OR 106 OR 107 OR 108 OR 109 OR 110 OR 111 OR 112 OR 113 OR 114 OR 115 OR 116 OR 117 OR 118 OR 119 OR 120 OR 121 OR 122 OR 123 OR 124 OR 125 OR 126 OR 127 OR 128 OR 129 OR 130 OR 131 OR 132 OR 133 OR 134 OR 135 OR 136 OR 137 OR 138 OR 139 OR 140 OR 141 OR 142 OR 143 OR 144 OR 145 OR 146 OR 147 OR 148 OR 149 OR 150 OR 151 OR 152 OR 153 OR 154 OR 155 OR 156 OR 157 OR 158 OR 159 OR 160 OR 161 OR 162 OR 163 OR 164 OR 165 OR 166 OR 167 OR 168 OR 169 OR 170 OR 171 OR 172 OR 173 OR 174 OR 175 OR 176 OR 177 OR 178 OR 179 OR 180 OR 181 OR 182 OR 183) Appendix F: Search terms for LILACS

1 "diabetes" OR diabet* OR iddm OR niddm OR diabetes OR diabeté OR diabetes OR hyper-glycemi* OR hyper-glycaemi* OR hyperglycemi* OR hyperglycaemi* OR hyperglycosemi* OR hyperglycosaemi* OR "blood glucose" OR "blood sugar" OR "plasma glucose" OR "plasma sugar" OR "serum glucose" OR "serum sugar" OR "glucose homeostasis" OR "glucose homeostatic" OR "glucose regulation" OR dysglycem* OR dysglycaem* OR glycemi* OR glycaemi* OR glucosaemi* OR glucosemi* OR "glycated haemoglobin A1c" OR "Glycated Hemoglobin" OR "glycated hemoglobin A1c" OR "Glycated Hemoglobins" OR "Glycohemoglobin A" OR "glycosylated haemoglobin A1c" OR "Glycosylated Hemoglobin" OR "haemoglobin a (1c)" OR "haemoglobin a 1c" OR "haemoglobin A1c" OR "haemoglobin aic" OR "hb a (1c)" OR "Hb A1" OR "Hb A1a+b" OR "Hb A1c" OR "hba 1c" OR "HbA1" OR "hba1c" OR "hemoglobin a (1c)" OR "hemoglobin a 1c" OR "Hemoglobin A(1)" OR "Hemoglobin A, Glycated" OR "Hemoglobin A, Glycosylated" OR "Hemoglobin A1c, Glycated" OR "Hemoglobin A1c, Glycosylated" OR "hemoglobin aic" OR "Hemoglobin, Glycosylated" OR "Hemoglobins, Glycated" OR hiperglucemia OR glucemia OR "glucosa en sangre" OR "azúcar en sangre" OR "glucosa en plasma" OR "azúcar en plasma" OR "glucosa plasmática" OR "azúcar plasmático" OR "glucosa en suero" OR "azúcar en suero" OR "glucosa sérica" OR "azúcar sérico" OR "disglucemia" OR "hemoglobina glicosilada" OR "hemoglobina glucosilada" OR hyperglycémie OR glycémie OR "glucose sanguin" OR "sucre sanguin" OR "sucre dans le sang" OR "glucose plasmatique" OR "sucre plasmatique" OR "glucose sérique" OR "sucre sérique" OR "concentrations sanguines en glucose" OR "concentrations sanguines en sucre" OR "dysglycémie" OR "hémoglobine glyquée" OR "hémoglobine glycosylée" OR hiperglicemia OR glicemia OR "concentração plasmática de glucose" OR "concentração plasmática de glicose" OR "glicose plasmática" OR "glucose plasmática" OR "açúcar de plasma" OR "concentração plasmática de açúcar" OR "glicose sérica" OR "glucose sérica" OR "açúcar sérico" OR "disglicemia" OR "hemoglobina glicosilada" OR "hemoglobina glicada" OR prediabet* OR pre-diabet* OR "impaired fasting glucose" OR "pre-diabético" OR "pré-diabéticos" OR "prédiabétique" OR "prédiabétiques" OR "pré-diabético" OR "pré-diabéticos" OR "glucose intolerance" OR "glucose intolerant" OR "glucose tolerance" OR "ogtt" OR "glucose load" OR "glucose loading test" OR "glucose test" OR "tolerancia a la glucosa" OR "intolerancia a la glucosa" OR "intolerante a la glucosa" OR "intolerantes a la glucosa" OR "tolérance au glucose" OR "quantité de glucose tolérée" OR "épreuve d'hyperglycémie provoquée" OR "intolérance au glucose" OR "tolerância à glicose" OR "tolerância à glucose" OR "intolerância à glicose" OR "intolerância à glucose" OR "intolerante à glicose" OR "intolerante à glucose" OR "intolerantes à glicose" OR "intolerantes à glucose" OR "insulin resistance" OR "insulin resistant" OR "insulin sensitivity" OR "insulin sensitive" OR "insulin insensitivity" OR "insulin insensitive" OR "metabolic syndrome" OR hyperinsuli* OR hyper-insuli* OR "insulin" OR "homeostasis model assessment" OR "homeostatic model assessment" OR "insulin test" OR "insulinorresistencia" OR "resistencia a la insulina" OR "resistencia insulínica" OR "resistente a la insulina" OR "resistentes a la insulina" OR "sensibilidad a la insulina" OR "sensible a la insulina" OR "sensibles a la insulina" OR "insensibilidad a la insulina" OR "insensible a la insulina" OR "insensibles a la insulina" OR "síndrome metabólico" OR hiperinsuli* OR insulina OR "insulino-résistance" OR "résistance à l'insuline" OR "insulino-résistant" OR "insulino-résistantes" OR "sensibilité à l'insuline" OR "sensible à l'insuline" OR "sensibles à l'insuline" OR "insensibilité à l'insuline" OR "insensible à l'insuline" OR "insensibles à l'insuline" OR "síndrome metabólico" OR hyperinsuli* OR insuline OR "resistência à insulina" OR "resistente à insulina" OR "resistentes à insulina" OR "sensibilidade à insulina" OR "sensível à insulina" OR "sensíveis à insulina" OR "insensibilidade à insulina" OR "insensível à insulina" OR "insensíveis à insulina" OR "síndrome metabólica" OR hiperinsuli* OR insulina OR hypoinsulin* OR hypo-insulin* OR "insulinopenia" OR "beta cell" OR "beta cells" OR "beta islet cell" OR "insulin producing cell" OR "insulin producing cells" OR "insulin secreting cell" OR "insulin secreting cells" OR "pancreas b cell" OR "pancreas beta islet cell" OR "pancreas islet b cell" OR "pancreatic b cell" OR "pancreatic islet b cell" OR "pancreatic islet b cell" OR hipoinsuli* OR insulinopenia OR "célula beta" OR "células beta" OR hipoinsuli* OR "insulinopénie" OR "cellule bêta" OR "cellules bêta" OR hipoinsuli* OR insulinopenia OR "célula beta" OR "células beta"

2 pesticid* OR "plaguicida" OR "plaguicidas" OR "pesticida" OR "pesticidas" 3 insecticid* OR "insecticida" OR "insecticidas" OR "inseticida" OR "inseticidas" 4 "carbamates" OR "carbamate" 5 "alanicarb" OR "alanycarb" OR "alanycarbe" 6 "aldicarb" OR "temik" OR "temick" OR "aldicarbe" 7 "aminocarb" OR "matacil" OR "4-dimethylamino-3-tolyl-N-methylcarbamate" OR "aminocarbe" OR "n-méthylcarbamate de 4-diméthylamino-3- méthylphènyle" OR "aminocarbo" OR "n-metilcarbamato de 4-dimetilamino-3-metilfenil"

8 "bendiocarb" OR "ficam" OR "bendiocarbe" OR "bendiocarba" 9 "benfuracarb" OR "benfurocarb" 10 "butocarboxim" OR "butocarboxime" OR "butocarboxima" 11 "butoxycarboxim" OR "butoxycarboxime" 12 "carbaryl" OR "carbaril" OR "carbyl" OR "carbarilo" 13 "carbofuran" OR "furadan" OR "curater" 14 "carbosulfan" OR "carbossulfão" 15 "croneton" OR "ethiofencarb" OR "kroneton" OR "éthiophencarbe" OR "etiofencarbe" 16 "BPMC" OR "fenobucarb" OR "fénobucarb" OR "fénobucarbe" OR "méthylcarbamate de 2-sec-butylphényle" 17 "Fenothiocarb" OR "fénothiocarb" 18 "fenoxycarb" OR "ethyl(2-(4-phenoxyphenoxy)ethyl)carbamate" OR "fenoxicarb" OR "phénoxycarbe" OR "insegar" 19 "formetanate" OR "formétanate" 20 "deltanit" OR "furathiocarb" OR "furatiocarb" OR "furathiocarbe" OR "furatiocarbe" Appendix F: Search terms for LILACS

21 "1-isopropyl-3-methyl-5-pyrazolyldimethylcarbamate" OR "dimethylcarbamic acid 1 isopropyl 3 methyl 5 pyrazolyl ester" OR "1 isopropyl 3 methyl 5 pyrazolyl dimethylcarbamate" OR "1 isopropyl 3 methylpyrazol 5 yl dimethylcarbamate" OR "dimethylcarbamic acid 1 isopropyl 3 methylpyrazol 5 yl ester" OR "primin" OR "primine" OR "isolane" 22 "isoprocarb" OR "phenyl-2-(1-methylethyl)methylcarbamate" OR "2-isopropylphenyl methylcarbamate" OR "isoprocarbo" OR "isoprocarbe"

23 "methiocarb" OR "mercaptodimethur" OR "mercaptodiméthur" OR "méthiocarbe" 24 "methomyl" OR "lannate" OR "méthomyl" 25 "metolcarb" OR "métolcarb" 26 "oxamyl" OR "vydate" 27 "pirimicarb" OR "pirimor" OR "pyrimor" OR "ZZ-Aphox" OR "pirimicarbe" OR "pyrimicarbe" 28 "propoxur" OR "O-Isopropoxyphenylmethylcarbamate" OR "O Isopropoxyphenylmethylcarbamate" OR "Unden" OR "sendran" OR "aprocarb"

29 "thiodicarb" 30 "thiofanox" OR "dacamox" OR "thiofanocarb" 31 "triazamate" 32 "trimethacarb" OR "landrin" OR "landrina" OR "trimétacarb" 33 "xmc" OR "carbaron" OR "3,5-xylyl methylcarbamate" OR "3,5-dimethylphenyl methylcarbamate" OR "cosban" OR "maqbarl" OR "macbal"

34 "xylylcarb" 35 "organophosphates" OR "organophosphate" OR "organothiophosphates" OR "organothiophosphate" OR "organophosphorus" OR "organophosphorous" OR "organothiophosphorus" OR "organothiophosphorous" OR "organofosfato" OR "organofosfatos" OR "phosphate organique" OR "fosfato orgânico" 36 "acephate" OR "O,S-dimethyl N-acetyl phosphoramidothioate" OR "orthene" OR "acefate" OR "acéphate" 37 "amiton" OR "O,O-diethyl S-(diethylaminoethyl) phosphorothiolate" OR "amitona" OR "amitão" 38 "azamethiphos" OR "azametifos" OR "azaméthiphos" 39 "azinphos ethyl" OR "azinphos-ethyl" OR "azinphosethyl" OR "ethyl azinphos" OR "ethyl-azinphos" OR "ethylazinphos" OR "azinfos-etil" OR "azinfos etil" OR "azinfosetil" OR "azinphos-éthyl" OR "azinphos éthyl" OR "azinphoséthyl" OR "azinfos-etilo" OR "azinfos etilo" OR "azinfosetilo" 40 "azinphosmethyl" OR "azinphos-methyl" OR "azinphos methyl" OR "methylazinphos" OR "methyl-azinphos" OR "methyl azinphos" OR "guthion" OR "azinfos-metil" OR "azinfos metil" OR "azinfosmetil" OR "azinfos metilico" OR "azinphos-méthyl" OR "azinphos méthyl" OR "azinphosméthyl" OR "azinfos-metilo" OR "azinfos metilo" OR "azinfosmetilo"

41 "cadusafos" OR "O-ethyl, S-bis(1-methylpropyl)phosphorodithioate" 42 "chlorethoxyfos" OR "chloréthoxyfos" 43 "chlorfenvinphos" OR "clofenvinfos" OR "chlorphenvinphos" OR "dermaton" OR "birlane" OR "clorfenvinfos" 44 "chlormephos" OR "chlorméphos" 45 "chlorpyrifos" OR "lorsban" OR "dursban" OR "chlorpyriphos-éthyl" OR "clorpirifos" 46 "chlorpyrifos-methyl" OR "chlorpyrifos methyl" OR "chlorpyrifosmethyl" OR "methyl-chlorpyrifos" OR "methyl chlorpyrifos" OR "methylchlorpyrifos" OR "dowco 214" OR "reldan" OR "clorpirifós-metilo" OR "clorpirifos-metil" OR "clorpirifos metil" OR "chlorpyriphos- méthyl" OR "clorpirifos-metilo" 47 "coumaphos" OR "asuntol" OR "cumafós" OR "cumafos" 48 "crufomate" OR "ruelene" OR "ruerene" OR "crufomato" 49 "cyanophos" OR "cyanox" OR "cianofos" 50 "cyanophenphos" OR "cyanofenphos" OR "surecide" 51 "cythioate" OR "cyflee" 52 "demeton-S-methyl" OR "demeton s methyl" OR "S-2-ethylthioethyl-O,O-dimethylphosphorothiolate" OR "déméton-S-méthyl" OR "demetão-S- metilo" 53 "diazinon" OR "dimpylate" OR "neocidol" OR "neotsidol" OR "bazudine" OR "diazinón" OR "diazinão" 54 "dichlorvos" OR "ddvp" OR "dichlofos" OR "dimethyl dichlorovinyl phosphate" OR "phosphoric acid 2,2-dichloroethenyl dimethyl ester" OR "phosphoric acid 2,2 dichloroethenyl dimethyl ester" OR "dichlorophos" OR "divipan" OR "novotox" OR "dichlorfos" OR "dichlorofos" OR "dichlorovos" OR "dichlorphos" OR "diclorvós" OR "diméthyl dichlorovinyl phosphate" OR "diclorvos"

55 "dicrotophos" OR "carbicron" OR "bidrin" OR "dicrotofos" 56 "dimethoate" OR "phosphamide" OR "rogor" OR "dimetoato" OR "diméthoate" OR "diméthoate" 57 "dimethylvinphos" OR "diméthylvinphos" Appendix F: Search terms for LILACS

58 "disulfoton" OR "thiodemeton" OR "di-syston" OR "di syston" OR "disyston" OR "demeton" OR "thiometon ethyl" OR "thiometon-ethyl" OR "thiometonethyl" OR "ethyl thiometon" OR "ethyl-thiometon" OR "ethylthiometon" OR "disulfotón" OR "dissulfotão" 59 "phenylphosphonothioic acid, 2-ethyl 2-(4-nitrophenyl) ester" OR "phenylphosphonothioic acid o ethyl o (4 nitrophenyl) ester" OR "O-Ethyl-O- (4-nitrophenyl)phenylphosphonothioate" OR "benzenephosphonothioic acid o ethyl o 4 nitrophenyl ester" OR "epn" OR "ethyl 4 nitrophenyl phenylphosphonothioate" OR "o (4 nitrophenyl) o ethyl phenylphosphonothioate" OR "o ethyl o (4 nitrophenyl) phenylthiophosphonate" OR "o ethyl o (4 nitrophenyl) phenylphosphonothioate" OR "o ethyl o 4 nitrophenyl benzenephosphonothioate" OR "o ethyl o 4 nitrophenyl benzenethiophosphonate" OR "o ethyl o 4 nitrophenyl phenylphosphonothioate" OR "o ethyl o 4 nitrophenyl phenylphosponothionate" OR "o ethyl o 4 nitrophenylphenylphosphonothioic acid" OR "o ethyl o para nitrophenyl phenylphosphonothioate" OR "o ethyl o para nitrophenyl phenylphosphonothionate" OR "o ethyl o para nitrophenyl phenylthiophosphonate" OR "phenylphosphonethioic acid o ethyl o para nitrophenyl ester" OR "phenylphosphonothioic acid ethyl 4 nitrophenyl ester" OR "phenylphosphonothioic acid o ethyl o 4 nitrophenyl ester" OR "phenylphosphonothioic acid o ethyl o para nitrophenyl ester" OR "phenylphosphonothioic acid, 2 ethyl 2 (4 nitrophenyl) ester" OR "phenylphosphonothioic acid, 2-ethyl 2- (4-nitrophenyl) ester" OR "phenylphosphonothioic acid, o-ethyl o- (4-nitrophenyl) ester") NOT "emphysematous pyelonephritis" OR "phénylthiophosphonate de o-éthyle et de o-(4-nitrophényle)" OR "o-etil-o-4-nitrofenil fenilfosfonotionato"

60 "ethion" OR "diethion" OR "ethopaz" OR "nialate" OR "ethyl methylene phosphorodithioate" OR "diethion" OR "etión" OR "éthion" OR "diéthion" OR "diéthon" OR "etião" 61 "ethoprophos" OR "ethoprop" OR "O-ethyl S,S-diprophyl phosphorodithioate" OR "mocap" OR "o ethyl s, s dipropyl phosphorodithioate" OR "o ethyl s, s dipropylphosphorodithioate" OR "phosphorodithioic acid o ethyl s, s dipropyl ester" OR "prophos" OR "ethoprofos" OR "éthoprophos" OR "etoprofos" 62 "etrimfos" OR "ekamet" OR "o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioic acid o, o dimethyl ester" OR "o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidyl) phosphorothioate" OR "o, o dimethyl o (6 ethoxy 2 ethylpyrimidin 4 yl) phosphorothioate" OR "phosphorothioic acid o, o dimethyl o (6 ethoxy 2 ethyl 4 pyrimidinyl) ester" OR "étrimfos" 63 "famophos" OR "O,O-dimethyl O-p-(dimethylsulfamoyl)phenylphosphorothioate" OR "famphur" OR "warbex" OR "varbex" 64 "fenamiphos" OR "ethyl 4-(methylthio)m-tolyl isopropylphosphoroamidate" OR "phenamiphos" OR "nemacur" OR "fenamifos" OR "fénamiphos" OR "phénamiphos" 65 "fenitrothion" OR "metathion" OR "dolithion" OR "nitrophos" OR "sumithion" OR "sumithione" OR "accothion" OR "agrothion" OR "dimethyl (3 methyl para nitrophenyl) phosphorothioate" OR "fenitrotion" OR "fenthrothion" OR "fentrothion" OR "folithion" OR "nuvanol" OR "o, o dimethyl o (3 methyl 4 nitrophenyl) phosphorothioate" OR "o, o dimethyl o (3 methyl 4 nitrophenyl) thionophosphate" OR "o, o dimethyl o (3 methyl 4 nitrophenyl) thiophosphate" OR "o, o dimethyl o (3 methyl para nitrophenyl) phosphorothioate" OR "o, o dimethyl o (4 nitro 1, 3 tolyl) phosphorothioate" OR "o, o dimethyl o (para nitro meta tolyl) phosphorothioate" OR "o, o dimethyl o para nitro meta tolylphosphorothioate" OR "phenitrothion" OR "fenitrotión" OR "fenitrotion" OR "fénitrothion" OR "fenitrotião"

66 "fensulfothion" OR "(4 methylsulfinylphenyl) phosphorothioic acid diethyl ester" OR "dasanit" OR "dansit" OR "diethyl (4 methylsulfinylphenyl) phosphorothioate" OR "o, o diethyl o (4 methylsulfinyl) phosphorothioic acid" OR "o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate" OR "o, o diethyl o (4 methylsulfinylphenyl) phosphorothioate" OR "o, o diethyl o (para methylsulfinylphenyl) phosphorothioate" OR "phosphorothioic acid o, o diethyl o (4 methylsulfinylphenyl) ester" OR "terracur" OR "fensulfotião" 67 "fenthion" OR "mercaptophos" OR "lebaycid" OR "4 methylmercapto 3 methylphenyl dimethyl thiophosphate" OR "dimethyl (3 methyl para methylthiophenyl) phosphorothioate" OR "dimethyl (4 methylthio) meta tolyl phosphorothioate" OR "entex" OR "fenthione" OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) phosphorothioate" OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate" OR "o, o dimethyl o (3 methyl 4 methylthiophenyl) thiophosphate" OR "o, o dimethyl o (3 methyl para methylthiophenyl) phosphorothioate" OR "o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate" OR "o, o dimethyl o (4 methylmercapto 3 methylphenyl) thionophosphate" OR "o, o dimethyl o (4 methylthio 3 methylphenyl) thiophosphate" OR "queletox" OR "spotton" OR "tiguvon" OR "fention"

68 "fonofos" OR "dyfonate" OR "dyphonate" OR "ethylphosphonodithioic acid o ethyl s phenyl ester" OR "fonophos" OR "o ethyl s phenyl ethylphosphonodithioate" 69 "formothion" OR "anthio" OR "antio" OR "anfix" OR "s (n formyl n methylcarbamoylmethyl) o, o dimethyl phosphorodithioate" OR "formotión" OR "formotião" 70 "fosthiazate" OR "(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate" OR "fosthiasate" 71 "heptenophos" OR "hostaquick" OR "ragadan" OR "hepténophos" 72 "imicyafos" 73 "isofenphos" OR "isophenphos" OR "isopropylphosphoramidothioic acid o ethyl o 2 isopropoxycarbonylphenyl ester" OR "o ethyl o 2 isopropoxycarbonylphenyl isopropylphosphoramidothioate" OR "oftanol" OR "isofenfos" OR "isophenphos"

74 "isocarbophos" OR "O-2-isopropoxycarbonylphenyl O-methyl phosphoramidothioate" 75 "isoxathion" OR "isoxatión" OR "isoxatião" Appendix F: Search terms for LILACS

76 "leptophos" OR "phosvel" OR "o (2, 5 dichloro 4 bromophenyl) o methylphenylthiophosphonate" OR "phenylphosphonothioic acid o (4 bromo 2, 5 dichlorophenyl) o methyl ester" 77 "malaoxon" OR "malathion oxon" OR "malaoxón" OR "malaoxão" 78 "karbofos" OR "carbophos" OR "carbafos" OR "carbofos" OR "prioderm" OR "sadophos" OR "cythion" OR "derbac m" OR "fosfotion" OR "fyfanon" OR "kypfos" OR "lusap" OR "malathione" OR "malathon" OR "malthion" OR "malthione" OR "nalathion" OR "o, o dimethyl dithiophosphate of diethyl mercaptosuccinate" OR "o, o dimethyldithiophosphate derivative of diethyl succinate" OR "organoderm" OR "ovide" OR "phosphothion" OR "prioderm" OR "(1, 2 dicarbethoxyethyl) o, o dimethyl phosphorodithioate" OR "s (1, 2 dicarbethoxyethyl) o, o dimethyldithiophosphate" OR "sadofos" OR "zithiol" OR "maldison" OR "mercaptothion" OR "malathión" OR "malation" OR "malatião" 79 "mecarbam" OR "S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl)-O,O-diethylphosphorodithioate" OR "Murfatox" OR "mécarbame" OR "mecarbame" 80 "methacrifos" OR "méthacrifos" 81 "methamidophos" OR "O,S-dimethylphosphoroamidothioate" OR "metamidophos" OR "tamaron" OR "metamidofos" OR "méthamidophos"

82 "methidathion" OR "metidathion" OR "Supracide" OR "metidatión" OR "méthidathion" OR "metidatião" 83 "mevinphos" OR "fosdrin" OR "phosdrin" OR "fosdrine" OR "(1 carbomethoxy) 1 propen 2 yl dimethyl phosphate" OR "(2 carbomethoxy 1 methylvinyl) dimethyl phosphate" OR "(carbomethoxypropen 2 yl) dimethyl phosphate" OR "(carbomethoxypropen 2 yl) dimethyl phosphate" OR "(carbomethoxypropen 2 yl) dimethylphosphate" OR "1 carbomethoxy 1 propen 2 yl dimethyl phosphate" OR "1 carbomethoxy 1 propen 2 yl dimethylphosphate" OR "1 carbomethoxy 1 propen 2 yldimethyl phosphate" OR "mévinphos" OR "mévinphos"

84 "mipafox" OR "bis (isopropylamino) fluorophosphine oxide" OR "isopestox" OR "mipafor" 85 "monocrotophos" OR "nuvacron" OR "azodrin" OR "3 (dimethoxyphosphinoyloxy) n methyl cis crotonamide" OR "3 (dimethoxyphosphinyloxy) n methyl cis crotonamide" OR "3 (dimethoxyphosphinyloxy) n methylcrotonamide" OR "3 [(dimethoxyphosphinoyl) oxy] n methyl cis crotonamide" OR "monocrotofós" 86 "naled" OR "1, 2 dibromo 2, 2 dichloroethyl dimethyl phosphate" OR "1, 2 dibromo 2, 2 dichloroethyl dimethylphosphate" OR "1, 2 dibromo 2, 2 dichloroethyldimethyl phosphate" OR "alvora" OR "bromex" OR "dibrom" OR "o, o dimethyl o (1, 2 dibromo 2, 2 dichloroethyl) phosphate" OR "phosphoric acid (1, 2 dibromo 2, 2 dichloroethyl) dimethyl ester" OR "phosphoric acid 1, 2 dibromo 2, 2 dichloroethyl dimethyl ester" OR "bromchlophos" OR "nalede" 87 "dimethoxon" OR "omethoate" OR "o-methoate" OR "folimat" OR "o, o dimethyl s (n methylcarbamoylmethyl) phosphorothioate" OR "phosphorothioic acid o, o dimethyl s (n methylcarbamoylmethyl) ester" OR "ométhoate" OR "ométhoate" OR "ometoato" 88 "methyl demeton" OR "methyl-demeton" OR "oxydemeton methyl" OR "oxydemeton-methyl" OR "oxydemeton methyl" OR "oxydemeton- methyl" OR "oxydemetonmethyl" OR "methyl oxydemeton" OR "methyl-oxydemeton" OR "methyloxydemeton" OR "demeton-methyl" OR "O,O- dimethyl S-(2-(ethylsulfinyl)ethyl)phosphorothioate" OR "metasystox" OR "methylmercaptophos oxide" OR "oxidemetón-metil" OR "oxidemetón metil" OR "oxidemetónmetil" OR "oxydéméton-méthyl" OR "oxydéméton méthyl" OR "oxydémétonméthyl" OR "oxidemetão- metilo" OR "oxidemetão metilo" OR "oxidemetãometilo" 89 "alkron" OR "aphamite" OR "corthion" OR "diethyl nitrophenyl thiophosphate" OR "diethyl p nitrophenyl monothiophosphate" OR "diethylparathion" OR "dimethyl para nitrophenolthiophosphate" OR "ecatox" OR "ekatox" OR "ethyl parathion" OR "ethylparathion" OR "etilon" OR "folidol" OR "isoparathion" OR "niran" OR "nitrostigmine" OR "o, o diethyl o (4 nitrophenyl) phosphorothioate" OR "o, o diethyl o (4 nitrophenyl) thiophosphate" OR "o, o diethyl o (para nitrophenyl) phosphorothioate" OR "o, o diethyl o p nitrophenyl phosphorothioate" OR "paraphos" OR "parathion" OR "phosphemol" OR "phosphorothioic acid o, o diethyl o (4 nitrophenyl) ester" OR "phosphostigmine" OR "thiophos" OR "tiofos" OR "paratión" OR "paratião" 90 "methyl parathion" OR "methyl-parathion" OR "methylparathion" OR "parathion methyl" OR "parathionmethyl" OR "parathion-methyl" OR "demethylfenitrothion" OR "dimethyl para nitrophenyl phosphorothioate" OR "dimethyl para nitrophenylphosphorothioate" OR "dimethyl (para nitrophenyl) phosphorothioate" OR "dimethylnitrophenylthiophosphate" OR "dimethylparathion" OR "fenitrothion, demethyl" OR "metaphos" OR "norfenitrothion" OR "o, o dimethyl o (para nitrophenyl) phosphorothioate" OR "o, o dimethyl o (para nitrophenyl) thiophosphate" OR "o, o dimethyl o (para nitrophenyl) phosphorothioate" OR "o, o dimethyl o (para nitrophenyl) phosphorothionate" OR "o, o dimethyl o para nitrophenyl phosphorothioate" OR "o, o dimethyl para nitrophenyl phosphorothioate" OR "phosphorothioic acid o, o dimethyl o (4 nitrophenyl) ester" OR "vofatox" OR "vophatox" OR "wofatox" OR "dalf" OR "metaphos" OR "paratión-metil" OR "paratión metil" OR "paratiónmetil" OR "paration metilico" OR "parathion-méthyl" OR "parathion méthyl" OR "parathionméthyl" OR "paratião-metilo" OR "paratião metilo" OR "paratiãometilo"

91 "phenthoate" OR "elsan" OR "phendal" OR "cidial" OR "cidiale" OR "dimethenthoate" OR "fenthoate" OR "phosphorodithioic acid s (alpha carbethoxybenzyl) o, o dimethyl ester" OR "s alpha ethoxycarbonylbenzyl o, o dimethyl phosphorodithioate" OR "tannone" OR "o,o-dimethyl S- alpha-ethoxycarbonylbenzylphosphorodithioate" OR "fentoato" 92 "phorate" OR "diethyl ethylthiomethyl phosphorodithioate" OR "l 11 6" OR "o, o diethyl s (ethylthiomethyl) phosphorodithioate" OR "o, o diethyl s (ethylthiomethyl) phosphorodithioate" OR "phorates" OR "phosphorodithioic acid o, o diethyl s [(ethylthio) methyl] ester" OR "thimet" OR "timet" OR "forato" Appendix F: Search terms for LILACS

93 "phosalone" OR "phozalone" OR "phoazlone" OR "fozalone" OR "fosalone" OR "fosalon" OR "o, o diethyl s (6 chloro 2 oxobenzoxazolin 3 ylmethyl) phosphorodithioate" OR "s (6 chloro 2 oxobenzoxazolin 3 yl) methyl diethyl phosphorothiolothioate" OR "zolone" OR "benzophosphate" OR "fosalona" 94 "phosmet" OR "fosmet" OR "imidan" OR "n (mercaptomethyl) phthalimide s (o, o dimethyl) phosphorodithioate" OR "n (mercaptomethyl) phthalimide s (o, o dimethylphosphorodithioate)" OR "o, o dimethyl s (phthalimidomethyl) phosphorodithioate" OR "o, o dimethyl s phthalimidomethyl phosphorodithioate" OR "phosphorodithioic acid o, o dimethyl s phthalimidomethyl ester" OR "porect" OR "phthalophos" OR "fosmet" OR "fosmete" 95 "phosphamidon" OR "2 chloro n, n diethyl 3 hydroxycrotonamide dimethyl phosphate" OR "dimecron" OR "dimethyl (2 chloro 1 diethylaminocroton 3 yl) phosphate" OR "liromidon" OR "o, o dimethyl o (2 chloro 1 diethylaminocroton 3 yl) phosphate" OR "fosfamidon" 96 "phoxim" OR "phenylglyoxylonitrile oxime o,o-diethylphosphorothioate" OR "valekson" OR "valexon" OR "sebacil" OR "foxim" OR "o (alpha cyanobenzylideneamino) o, o diethyl phosphorothioate" OR "o, o diethyl o (alpha cyanobenzylideneamino) phosphorothioate" OR "phenylglyoxylonitrile oxime o, o diethylphosphorothioate" OR "volaton" OR "foxim" OR "phoxime" 97 "pirimiphos methyl" OR "pirimiphosmethyl" OR "pirimiphos-methyl" OR "methyl-pirimiphos" OR "methyl pirimiphos" OR "methylpirimiphos" OR "o-(2-(diethylamino)-6-methyl-4-pyrimidinyl) o,o- dimethylphosphorothioate lic" OR "piritione" OR "actellic" OR "aktel" OR "pirimifos metil" OR "pirimifos-metil" OR "pyrimiphos-méthyl" OR "pirimifos-metilo" 98 "profenofos" OR "curacron" OR "selecron" OR "o (4 bromo 2 chlorophenyl) o ethyl s propyl phosphorothioate" OR "phosphorothioic acid o (4 bromo 2 chlorophenyl) o ethyl s propyl ester" OR "profénofos" 99 "propetamphos" OR "propétamphos" 100 "prothiophos" OR "prothiofos" OR "tokuthion" OR "tukuthion" 101 "pyraclofos" OR "o-(1-(4-chlorophenyl)-4-pyrazolyl) o-ethyl S-propyl phosphorothioate" 102 "pyridafenthion" OR "o,o-diethyl o-(3-oxo-2-phenyl-2H-pyridazin-6- yl) phosphorothioate" OR "pyridaphenthion" OR "ofunack" OR "o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) phosphorothioate" OR "phosphorothioic acid o, o diethyl o (2, 3 dihydro 3 oxo 2 phenyl 6 pyridazinyl) ester" OR "pyridaphenthione" 103 "quinalphos" OR "diethylquinalphione" OR "o,o-diethyl-o-(quinoxalinyl-(2))thionophosphate" OR "o,o-diethyl-o-(quinoxalyl)phosphorothioate" OR "o, o diethyl o (2 quinoxalinyl) phosphorothioate" OR "phosphorothioic acid o, o diethyl o (2 quinoxalinyl) ester" OR "bayrusil" OR "ekalux" OR "bayer 77049" OR "chinalphos" 104 "sulfotepp" OR "sulfotep" OR "ethyl thiopyrophosphate" OR "asymmetric tetraethyl dithiopyrophosphate" OR "dithiopyrophosphate de tétraéthyle" OR "ditiopirofosfato de tetraetilo" 105 "tebupirimphos" OR "tébupirimfos" 106 "temefos" OR "temephos" OR "difos" OR "abathion" OR "temefós" OR "téméfos" OR "téméphos" 107 "terbufos" OR "o,o-diethyl s((tert-butylthio)methyl)phosphorodithioate" OR "o, o diethyl s (tert butylthio) methylphosphorodithioate" 108 "tetrachlorvinphos" OR "stirofos" OR "gardona" OR "rabon" OR "2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethylphosphate" OR "2 chloro 1 (2, 4, 5 trichlorophenyl) vinyldimethylphosphate" OR "phosphoric acid 2 chloro 1 (2, 4, 5 trichlorophenyl) vinyl dimethyl ester" OR "stirophos" OR "tetrachlorofenvinphos" OR "tetraclorvinfos" OR "tétrachlorvinphos" 109 "thiometon" OR "ekatin" OR "intration" OR "aasystem" OR "duphar dimeaat" OR "ecatin" OR "intrathion" OR "intrathione" OR "luxan" OR "o, o dimethyl s (2 ethylthioethyl) phosphorodithioate" OR "o, o dimethyl s (2 ethylthioethyl) phosphorodithioate" OR "o, o dimethyl s ethylthioethyl phosphorodithioate" OR "sysmeton" OR "tiometon" OR "thiométon" OR "dithiométon" OR "tiometão" 110 "triazophos" OR "1-phenyl-3-(o,o-diethylthiophosphoryl)-1,2,4- triazole" OR "hostathion" OR "o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) phosphorothioate" OR "phosphorothioic acid o, o diethyl o (1 phenyl 1h 1, 2, 4 triazol 3 yl) ester" 111 "merphos" OR "tributyl phosphorotrithioite" OR "s,s,s-tributyl phosphorotrithioite" OR "folex" OR "tributyl-phosphorotrithioite" OR "tributylphosphorotrithioite" OR "phosphorotrithioite tributyl" OR "phosphorotrithioite-tributyl" OR "phosphorotrithioitetributyl" 112 "chlorophos" OR "chlorofos" OR "metrifonate" OR "dipterex" OR "dylox" OR "neguvon" OR "ricifon" OR "bilarcil" OR "bilacil" OR "bilharcil" OR "foschlor" OR "2, 2, 2 trichloro 1 hydroxyethylphosphonic acid dimethyl ester" OR "bay a 9826" OR "bay a9826" OR "bayer 15922" OR "bayer 2349" OR "bayer l 13-59" OR "bayer l 1359" OR "bayer l13-59" OR "bayer l1359" OR "combot" OR "dimethyl (2, 2, 2 trichloro 1 hydroxyethyl) phosphonate" OR "dyrex" OR "dyvon" OR "etfoschlor" OR "flibol e" OR "masoten" OR "metriphonate" OR "metrifonate" OR "metrofinate" OR "o, o dimethyl 1 hydroxy 2, 2, 2 trichloroethylphosphonate" OR "o, o dimethyl 2, 2, 2 trichloro 1 hydroxyethylphosphonate" OR "o, o dimethyl (1 hydroxy 2, 2, 2 trichlorethyl) phosphonate" OR "promem" OR "promen" OR "trichlorfon" OR "trichlorofon" OR "trichlorophon" OR "trichlorophone" OR "trichlorphon" OR "trichlorphone" OR "tugon" OR "dipterex" 113 "o,o-dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl)phosphorothioate" OR "kilval" OR "vamidothion" OR "vamidotión" OR "vamidotion" OR "vamidotião" 114 "fiproles" OR "fiprole" 115 "ethiprole" OR "éthiprole" 116 "fipronil" OR "fiprex" Appendix F: Search terms for LILACS

117 "pyrethrin" OR "pyrethrins" OR "pyrethroid" OR "pyrethroids" OR "ipevet" OR "ipevetex" OR "pyrethrasin" OR "piretroide" OR "piretroides" OR "pyréthroïde" 118 "acrinathrin" OR "acrinatrina" 119 "allethrin" OR "allethrins" OR "3 allyl 2 methyl 4 oxo 2 cyclopenten 1 yl chrysanthemate" OR "3 allyl 2 methyl 4 oxo 2 cyclopentenyl chrysanthemate" OR "allethrine" OR "allyl cinerin" OR "allethroxyl d, l cis, trans chrysanthemate" OR "pynamin" OR "pyresyn" OR "d-aletrin" OR "d-aletrina" OR "d-cis/trans-aletrina" OR "aletrin" OR "alléthrine" OR "palléthrine" OR "aletrina" 120 "bifenthrin" OR "bifenthrine" OR "fmc 54800" OR "fmc54800" OR "talstar" OR "bifentrin" OR "bifenthrine" OR "bifentrina" 121 "bioallethrin" OR "allethrin, bio" OR "s-bioallethrin" OR "d-trans-allethrin" OR "bioallethrine" OR "bioalléthrine" OR "dépalléthrine" OR "bioaletrina" 122 "bioresmethrin" OR "trans-resmethrin" OR "ru 11484" OR "d-trans-resmethrin" OR "bioresmetrina" OR "bioresméthrine" 123 "cismethrin" OR "5-benzyl-3-furylmethyl(1.R)-cis-chrysanthemate" OR "NRDC 119" OR "cis (+) resmethrin" OR "methrin, cis" OR "resmethrin, cis (+)" OR "cisméthrine" 124 "cycloprothrin" OR "cycloprothrine" 125 "cyfluthrin" OR "oms 2012" OR "oms-2012" OR "beta-cyfluthrin" OR "beta cyfluthrin" OR "bay fcr 1272" OR "bay fcr1272" OR "baythroid" OR "baytroid" OR "ciflutrin" OR "cyfloxylate" OR "fcr 1272" OR "fcr1272" OR "ciflutrin" OR "ciflutrina" OR "cyflutrin" OR "cyfluthrine" OR "bêta- cyfluthrine" OR "bêtacyfluthrine" 126 "cyhalothrin" OR "lambda-cyhalothrin" OR "lambdacyhalothrin" OR "pp 321" OR "oms 3021" OR "oms-3021" OR "gamma cyhalothrin" OR "gamma-cyhalothrin" OR "gammacyhalothrin" OR "cihalotrina" OR "cihalotrin" OR "cyalotrina" OR "cyhalotrina" OR "gamma-cihalotrina" OR "gamma-cihalotrin" OR "gamma-cyalotrina" OR "gamma-cyhalotrina" OR "gammacihalotrina" OR "gammacihalotrin" OR "gammacyalotrina" OR "gammacyhalotrina" OR "lambda-cihalotrina" OR "lambda-cihalotrin" OR "lambda-cyalotrina" OR "lambda-cyhalotrina" OR "lambdacihalotrina" OR "lambdacihalotrin" OR "lambdacyalotrina" OR "lambdacyhalotrina" OR "cyhalothrine" OR "gamma-cyhalothrine" OR "gammacyhalothrine" OR "lambda-cyhalothrine" OR "lambdacyhalothrine" OR "cialotrina" OR "lambda-cialotrina" OR "lambdacialotrina" OR "gamma-cialotrina" OR "gammacialotrina" 127 "2 (2, 2 dichlorovinyl) 3, 3 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester" OR "3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester" OR "3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylic acid meta phenoxymandelonitrile ester" OR "alfa cypermethrin" OR "alfa methrin" OR "alfa methrine" OR "alfacypermethrin" OR "alfamethrin" OR "alfamethrine" OR "alpha cyano 3 phenoxybenzyl 3 (2, 2 dichlorovinyl) 2, 2 dimethylcyclopropanecarboxylate" OR "alpha cypermethrin" OR "alpha cypermethrine" OR "alpha-cypermethrin" OR "alphacypermethrin" OR "alpha methrin" OR "alpha methrine" OR "alphacypermethrin" OR "alphamethrin" OR "alphamethrine" OR "barricade" OR "beta cypermethrine" OR "beta cypermethrin" OR "beta-cypermethrin" OR "betacypermethrin" OR "ccn 52" OR "ccn52" OR "cipermethrin" OR "cis cypermethrin" OR "cypermethrine" OR "cypermetrin" OR "flectron" OR "fmc 30980" OR "fmc30980" OR "nrdc 149" OR "nrdc 182" OR "nrdc149" OR "nrdc182" OR "wl 43467" OR "wl 85871" OR "wl43467" OR "wl85871" OR "supermethrin" OR "supercypermethrin" OR "cymbush" OR "fastac 50EC" OR "fendona" OR "beta-cipermetrina" OR "theta cypermethrin" OR "theta-cypermethrin" OR "thetacypermethrin" OR "zeta cypermethrin" OR "zeta-cypermethrin" OR "zetacypermethrin" OR "cypermetrina" OR "alfa-cypermetrina" OR "alfacypermetrina" OR "beta-cypermetrina" OR "betacypermetrina" OR "theta-cypermetrina" OR "thetacypermetrina" OR "zeta-cypermetrina" OR "zetacypermetrina" OR "cipermetrina" OR "alfa-cipermetrina" OR "alfacipermetrina" OR "beta- cipermetrina" OR "betacipermetrina" OR "theta-cipermetrina" OR "thetacipermetrina" OR "zeta-cipermetrina" OR "zetacipermetrina" OR "cyperméthrine" OR "alpha-cyperméthrine" OR "alphacyperméthrine" OR "bêta-cyperméthrine" OR "bêtacyperméthrine" OR "thêta- cyperméthrine" OR "thêtacyperméthrine" OR "zêta-cyperméthrine" OR "zêtacyperméthrine"

128 "cyphenothrin" OR "cis-cyphenothrin" OR "alpha cyano 3 phenoxybenzyl chrysanthemate" OR "chrysanthemic acid alpha cyano 3 phenoxybenzyl ester" OR "cifenotrin" OR "cifenotrina" OR "cyphénothrine" 129 "decamethrin" OR "deltamethrin" OR "butox" OR "oms 1998" OR "difexon" OR "k-othrin" OR "nrdc 161" OR "decis" OR "deltanil" OR "k othrine" OR "pediculosane" OR "deltametrin" OR "deltaméthrine" OR "deltametrina" 130 "empenthrin" OR "1-ethynyl-2-methyl-2-pentenyl chrysanthemate" OR "s 2852f" OR "s-2852f" OR "vaporthrin" OR "d-empenthrin" OR "empenthrine" OR "empentrin" OR "empenthrine" OR "empentrina" 131 "esfenvalerate" OR "esfenvalerato" OR "esfenvalérate" 132 "ethofenprox" OR "2-(4-ethoxyphenyl)-2-methylpropyl-3-phenoxybenzyl ether" OR "etofenprox" OR "Trebon" OR "etofenprox" OR "étofenprox" OR "etofemprox" 133 "fenpropathrin" OR "(alpha cyano 3 phenoxybenzyl) 2, 2, 3, 3 tetramethylcyclopropanecarboxylate" OR "2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid (alpha cyano 3 phenoxybenzyl) ester" OR "2, 2, 3, 3 tetramethylcyclopropanecarboxylic acid alpha cyano 3 phenoxybenzyl ester" OR "alpha cyano 3 phenoxybenzyl 2, 2, 3, 3 tetramethylcyclopropanecarboxylate" OR "fenpropanate" OR "meothrin" OR "fenpropatrina" OR "fenpropatrin" OR "fenpropathrine" Appendix F: Search terms for LILACS

134 "fenvalarate" OR "(alpha cyano 3 phenoxybenzyl) 2 (4 chlorophenyl) 3 methylbutyrate" OR "2 (4 chlorophenyl) 3 methylbutyric acid (alpha cyano 3 phenoxybenzyl) ester" OR "2 (4 chlorophenyl) isovaleric acid alpha cyano 3 phenoxybenzyl ester" OR "3 phenoxymandelonitrile 2 (4 chlorophenyl) 2 isopropylacetate" OR "alpha cyano 3 phenoxybenzyl alpha isopropyl 4 chlorophenylacetate" OR "alpha isopropyl 4 chlorophenylacetic acid alpha cyano 3 phenoxybenzyl ester" OR "arkofly" OR "belmark" OR "cyano (3 phenoxyphenyl) methyl 4 chloro alpha (1 methylethyl) benzeneacetate" OR "ectrin" OR "phenvalerate" OR "pidrin" OR "pydrin" OR "pyrethroid sd 43775" OR "s 5602" OR "s-5602" OR "sd 43775" OR "sumicidin" OR "wl 43775" OR "sumi-alpha" OR "belmark" OR "alpha-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3- methylbutyrate" OR "alpha-cyano-3-phenoxybenzyl alpha-isopropyl-4-chlorophenyl acetate" OR "fenvalerato" OR "fenvalérate"

135 "flucythrinate" OR "(alpha cyano 3 phenoxybenzyl) 4 difluoromethoxy alpha isopropylphenylacetate" OR "4 difluoromethoxy alpha isopropylphenylacetic acid alpha cyano 3 phenoxybenzyl ester" OR "ac 222, 705" OR "ac 222705" OR "ac222, 705" OR "ac222705" OR "cyano (3 phenoxyphenyl) methyl 4 (difluoromethoxy) alpha (1 methylethyl) benzeneacetate"

136 "flumethrin" OR "bayticol" OR "flumetrina" OR "fluméthrine" 137 "fluvalinate" OR "tau-fluvalinate" OR "tau fluvalinate" OR "taufluvalinate" OR "mavrik" OR "fluvalinato" OR "tau-fluvalinato"

138 "halfenprox" OR "brofenprox" 139 "imiprothrin" OR "imiprotrin" OR "imiprotrina" OR "imiprothrine" 140 "kadethrin" OR "kadéthrine" 141 "permethrin" OR "cis-permethrin" OR "cis permethrin" OR "cispermethrin" OR "cis-(1rs)-permethrin" OR "trans-permethrin" OR "trans permethrin" OR "transpermethrin" OR "trans-(1rs)-permethrin" OR "pp-557" OR "pp 557" OR "pp557" OR "s-3151" OR "s 3151" OR "s3151" OR "elimite" OR "fmc-33297" OR "fmc 33297" OR "fmc33297" OR "nia-33297" OR "nia 33297" OR "nia33297" OR "nittifor" OR "nrdc-143" OR "nrdc 143" OR "nrdc143" OR "nrdc-147" OR "nrdc 147" OR "nrdc147" OR "acticin" OR "armol" OR "atroban" OR "dronol" OR "ectiban" OR "ectomethrin" OR "expar" OR "gamabenceno plus" OR "gamaderm" OR "infectopedicul" OR "klinits" OR "loxazol" OR "lyclear" OR "mite-x" OR "nedax plus" OR "new-nok" OR "novo-herklin 2000" OR "oms 1821" OR "perigen" OR "permanone" OR "permectrin" OR "permicren" OR "permite" OR "piopel" OR "quellada-p" OR "scabmite" OR "stockade" OR "stockate" OR "wl 43479" OR "zehu-ze" OR "permetrina" OR "permetrino" OR "permetrin" OR "perméthrine" 142 "d-phenothrin" OR "phenothrin" OR "sumithrin" OR "s-2539" OR "3 phenoxybenzyl chrysanthemate" OR "chrysanthemic acid 3 phenoxybenzyl ester" OR "fenothrin" OR "sumithrin" OR "fenotrin" OR "fenotrina" OR "1-r-trans-fenotrin" OR "1-r-trans-fenotrina" OR "1r trans-fenotrin" OR "1r trans-fenotrina" OR "1r-trans fenotrin" OR "1r-trans fenotrina" OR "1r-trans-fenotrin" OR "1r-trans-fenotrina" OR "d-fenotrin" OR "d- fenotrina" OR "phénothrine" 143 "2-methyl-4-oxo-3-(2-propynyl)cyclopent-2-enyl chrysanthemate" OR "prallethrin" OR "d,d-t80-prallethrin" OR "praletrina" OR "pralléthrine" 144 "pyrethrum" OR "pyrethrums" OR "cinerin" OR "cinerins" OR "jasmolin" OR "jasmolins" OR "pelitre" OR "piretrina" OR "piretrinas" OR "pyrèthre" OR "pyréthrines" OR "pyréthrine" OR "cinérine" OR "cinérines" OR "jasmoline" OR "piretro" 145 "resmethrin" OR "chryson" OR "sbp 1382" OR "scourge" OR "resméthrine" OR "resmetrina" 146 "silafluofen" OR "salifluofen" OR "silafluofène" 147 "tefluthrin" OR "téfluthrine" OR "teflutrina" 148 "tetramethrin" OR "3, 4, 5, 6 tetrahydrophthalimidomethyl chrysanthemate" OR "chrysanthemic acid 3, 4, 5, 6 tetrahydrophthalimidomethyl ester" OR "lenpoucid" OR "neopynamin" OR "neopynamine" OR "phthalthrin" OR "sanpouxil" OR "tetrametrina" OR "d-tetrametrina" OR "d- trans-tetrametrina" OR "tétraméthrine" 149 "tralomethrin" OR "tralometrina" OR "tralométhrine" 150 "transfluthrin" OR "transflutrin" OR "transflutrina" OR "transfluthrine" 151 "neonicotinoids" OR "neonicotinoid" OR "néonicotinoïde" 152 "acetamiprid" OR "td-2480" OR "td-2472" OR "acétamipride" 153 "clothianidin" OR "((e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine)" OR "ti-435" OR "ti 435" OR "1 (2 chloro 1, 3 thiazol 5 ylmethyl) 3 methyl 2 nitroguanidine" OR "1 (2 chloro 5 thiazolylmethyl) 3 methyl 2 nitroguanidine" OR "clothianidine" OR "clotianidin" OR "clothianidine" OR "clotianidina" 154 "dinotefuran" OR "1-methyl-2-nitro-3-((3-tetrahydrofuryl)methyl)guanidine" OR "mti-446" OR "mti 446" OR "2 methyl 1 nitro 3 (tetrahydrofurfuryl) guanidine" OR "dinotéfurane" 155 "imidacloprid" OR "1 (6 chloro 3 pyridylmethyl) n nitroimidazolidin 2 ylideneamine" OR "1-((6-chloro-3-pyridinyl)methyl)-n-nitro-2- imidazolidinimine" OR "premise 75" OR "imidaclopride" 156 "nitenpyram" OR "capstar" 157 "nithiazine" OR "tetrahydro-2-(nitromethylene)-2h-1,3-thiazine" OR "ski-71" OR "wl-35651" OR "ls-192830" OR "sd 35651" OR "sd-35651" OR "tetrahydro 2 nitromethylene 2h 1, 3 thiazine" 158 "thiacloprid" OR "thiaclopride" OR "3-((6-chloro-3-pyridinyl)methyl)-2-thiazolidinylidene cyanamide" OR "thiaclopride"

159 "thiamethoxam" OR "actara 25 WG" OR "cga 293343" OR "cga-293343" OR "thiaméthoxame" 160 "sulfoxaflor" OR "sulfoxaflore" Appendix F: Search terms for LILACS

161 "flupyradifurone" OR "4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan-2(5h)-one" OR "sivanto" 162 "triflumezopyrim" 163 "spinosyn" OR "spinosyns" OR "a 83543a" OR "a83543a" OR "lepicidin A" 164 "spinetoram" OR "xde-175" OR "spinétorame" 165 "spinosad" OR "ly 232105" OR "ly232105" OR "natroba" OR "espinosad" OR "espinosade" 166 "avermectin" OR "avermectins" OR "aversectin" OR "aversectins" OR "milbemycin" OR "milbemycins" OR "5-o-demethylavermectin a1a" OR "22, 23 dihydroavermectin b1" OR "milbemax" OR "moxidectin" OR "avermectina" OR "avermectinas" OR "avermectine" OR "milbemycine"

167 "abamectin" OR "vertimec" OR "avermectin B1" OR "enzec" OR "abamectina" OR "abamectine" 168 "emamectin benzoate" OR "emamectine" 169 "lepimectin" OR "lépimectine" 170 "milbemectin" OR "milbémectine" 171 "pymetrozine" OR "pymétrozine" 172 "pyrifluquinazon" OR "pyrifluquinazone" 173 "flonicamid" OR "n-cyanomethyl-4-trifluoromethylnicotinamide" OR "carbine" OR "flonicamide" 174 "bensultap" OR "bancol" 175 "cartap" OR "padan" OR "cartape" 176 "n, n-dimethyl-1,2,3-trithian-5-yl amine" OR "thiocyclam" OR "thiocyclame" 177 "thiosultap" OR "thosultap" OR "molosultap" OR "monomehypo" OR "monosultap" OR "bisultap" OR "dimehypo" OR "disosultap"

178 "amitraz" OR "mitaban" OR "taktic" OR "n-methyl-bis(2,4-xylyiminomethyl) amine" OR "u 36059" OR "amitraze" 179 "indoxacarb" OR "activyl" OR "dpx-mp062" OR "dpx mp 062" OR "dpx mp062" OR "dpxmp 062" OR "dpxmp062" OR "indoxacarbo" OR "indoxacarbe" 180 "metaflumizone" OR "métaflumizone" 181 "chlorantranilipole" OR "chlorantraniliprole" OR "dpx-e2y45" OR "rynaxypyr" OR "clorantraniliprol" 182 "cyantraniliprole" OR "ciantraniliprol" 183 "flubendiamide" 184 1 AND (2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31 OR 32 OR 33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 OR 45 OR 46 OR 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56 OR 57 OR 58 OR 59 OR 60 OR 61 OR 62 OR 63 OR 64 OR 65 OR 66 OR 67 OR 68 OR 69 OR 70 OR 71 OR 72 OR 73 OR 74 OR 75 OR 76 OR 77 OR 78 OR 79 OR 80 OR 81 OR 82 OR 83 OR 84 OR 85 OR 86 OR 87 OR 88 OR 89 OR 90 OR 91 OR 92 OR 93 OR 94 OR 95 OR 96 OR 97 OR 98 OR 99 OR 100 OR 101 OR 102 OR 103 OR 104 OR 105 OR 106 OR 107 OR 108 OR 109 OR 110 OR 111 OR 112 OR 113 OR 114 OR 115 OR 116 OR 117 OR 118 OR 119 OR 120 OR 121 OR 122 OR 123 OR 124 OR 125 OR 126 OR 127 OR 128 OR 129 OR 130 OR 131 OR 132 OR 133 OR 134 OR 135 OR 136 OR 137 OR 138 OR 139 OR 140 OR 141 OR 142 OR 143 OR 144 OR 145 OR 146 OR 147 OR 148 OR 149 OR 150 OR 151 OR 152 OR 153 OR 154 OR 155 OR 156 OR 157 OR 158 OR 159 OR 160 OR 161 OR 162 OR 163 OR 164 OR 165 OR 166 OR 167 OR 168 OR 169 OR 170 OR 171 OR 172 OR 173 OR 174 OR 175 OR 176 OR 177 OR 178 OR 179 OR 180 OR 181 OR 182 OR 183) Online appendix G: Draft forms for recording study data

Note: These forms are only drafts. They will be piloted and revised, and the final forms will be implemented in DistillerSR (rather than a paper form). Study characteristics form Identifying information Surname of first author + year of publication List authors Affiliation of authors Email address of corresponding author Title of article Name of journal Year of publication Journal issue Journal pages Digital object identifier (DOI) Direct link to article Study design Study design □ Cohort/follow-up □ Case-control □ Randomized trial □ Other (please specify): Study period (specify beginning and ending month) Study population Number of female study participants Number of male study participants Number of exposed participants Number of unexposed participants Country of study population Geographic location (specify as 'national' or list regions or sites) Age (specify age group or, if not age-disaggregated, state mean age & the standard deviation) Ethnicity Exposure assessment Type of exposure □ Environmental □ Occupational Specific insecticides (or classes of insecticides) assessed Mode of exposure data collection □ Pen-and-paper survey □ Face-to-face interview □ Computer survey □ Administrative records □ Biomarker: Pesticides or pesticide residues □ Biomarker: Choline esterase □ Environmental measurements □ Other (specify) If exposure determined by biomarkers Which specific biomarker? (pesticides or pesticide residues): Which specific medium? □ Whole blood □ Plasma □ Urine □ Hair □ Nails □ Other (specify) If exposure determined by biomarkers Which specific enzyme? □ Erythrocyte acetylcholine esterase (choline esterase): □ Plasma cholinesterase If erythrocyte acetylcholine esterase: □ No Normalized by haemoglobin concentration of blood? □ Yes If exposure determined by environmental Which sampling method? measurements: Which specific pesticide? If exposure determined from How were exposure metrics defined? questionnaire or interview: Type of metric □ Dichotomous □ Semi-quantitative / categorical □ Quantitative

Study results form Note: The same study may report results for a number of exposure-outcome pairs. The following information will be filled out for each exposure-outcome pair.

Parameter Example data (fictional) Identifying information Surname of first author + year of publication Smith 1982 Information on exposure-outcome pair Ever/never agricultural exposure to any Exposure definition organophosphate insecticides Diabetes mellitus, defined as a single Outcome (with definition / diagnostic criteria, if applicable) fasting plasma glucose value ≥ 8 mmol/liter □ Type 1 □ Type 2 If outcome is diabetes mellitus: Which type? □ Gestational □ Unspecified Statistical modelling Statistical methods used to produce estimate Logistic regression □ No Adjusted for ethnicity? □ Yes □ No Adjusted for HLA genotype? □ Yes □ No Adjusted for age? □ Yes □ No Adjusted for sex? □ Yes □ No Adjusted for family history of diabetes? □ Yes □ No Adjusted for weight status? □ Yes Adjusted for diet? □ No □ Yes Total calorie consumption from 24-hour If adjusted for diet, please indicate how dietary diary List any other confounders adjusted for Household income, smoking Results Odds ratio for diabetes for ever-exposed Effect measure type persons compared to never-exposed persons Point estimate 1.8 Lower confidence limit 1.5 Upper confidence limit 2.2 Unit for point estimate (if applicable) p-value for estimate (only if confidence interval is missing) Missing data Do we need to request crucial any missing data from study □ No authors? □ Yes If yes, what data do we need to request? Comments Write any comments here

Online appendix H: Instructions for assessment of risk of bias in individual studies Manuscript title: “Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis“

Modified from supplementary materials of the following systematic review: Johnson, Paula I., et al. "Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan." Environment International 92 (2016): 716-728. https://doi.org/10.1016/j.envint.2016.03.009

A. Domains relevant to experimental studies only

1. SEQUENCE GENERATION

Adequate sequence generation minimizes bias by using a random component to ensure the sequence is unpredictable.

Was the allocation sequence adequately generated?

Criteria for a judgment of LOW risk of bias: The investigators describe a random component in the sequence generation process such as: • Referring to a random number table; • Using a computer random number generator; • Coin tossing; • Shuffling cards or envelopes; • Throwing dice; • Drawing of lots.

Note that use of minimization (e.g., ensuring similar participant weights for all groups) does not put the study at risk of bias if combined with a random component.

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information about the sequence generation process to permit a judgment of low risk of bias, but there is indirect evidence that suggests the sequence generation process was random, as described by the criteria for a judgment of low risk of bias, such as: • Study authors make a simple statement such as ‘we randomly allocated’, but do not provide details regarding specific random component used in the sequence generation process; or

Page 1 of 13 • Study authors describe randomization for one experiment, and the methods for a second experiment are similar but do not specifically mention randomization.

Criteria for the judgment of PROBABLY HIGH risk of bias:

There is insufficient information about the sequence generation process to permit a judgment of high risk of bias, but there is indirect evidence that suggests a non-random component in the sequence generation process or that a random component, as described by the criteria for a judgment of low risk of bias, was not used such as: • Study authors do not make any statement about sequence generation and the review author does not find indirect evidence suggesting random sequence generation.

Criteria for the judgment of HIGH risk of bias:

The investigators state clearly that a random component was not used or describe a non-random component in the sequence generation process. Usually, the description would involve some systematic, non-random approach, for example: • Sequence generated by date of birth; • Sequence generated by some rule based on date (or day) of arrival at facility; • Sequence generated by some rule based on record number. Other non-random approaches happen much less frequently than the systematic approaches mentioned above and tend to be obvious. They usually involve judgment or some method of non-random categorization of participants, for example: • Allocation by judgment of the investigator; • Allocation by availability of the intervention; • Alternate allocation.

2. ALLOCATION CONCEALMENT

Adequate allocation concealment minimizes bias by protecting the allocation sequence before and until assignment.

Was allocation adequately concealed?

Criteria for a judgment of LOW risk of bias:

Investigators could not foresee assignment because one of the following, or an equivalent method, was used to conceal allocation: • Sequentially numbered treatment containers of identical appearance to control; or

Page 2 of 13 • Sequentially numbered prepared route of administration (e.g., pre-prepared water dosed with chemical) of identical appearance; or • Study personnel assigned allocation, and separate study personnel administered treatment without knowledge of assignments; or • Sequentially numbered, opaque, sealed envelopes.

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information about allocation concealment to permit a judgment of low risk of bias, but there is indirect evidence that suggests the allocation was adequately concealed, as described by the criteria for a judgment of low risk of bias such as: • Review author finds indirect evidence suggesting allocation concealment, but study authors do not provide details about how investigators were prevented from foreseeing assignment; or • Study authors state that participants were given identification numbers prior to treatment, or authors describe allocation concealment for one experiment, and the methods for a second experiment are similar but do not specifically mention allocation concealment.

Criteria for the judgment of PROBABLY HIGH risk of bias:

There is insufficient information about allocation concealment to permit a judgment of high risk of bias, but there is indirect evidence that suggests the allocation was not adequately concealed, as described by the criteria for a judgment of high risk of bias such as: • Study authors do not make any statement about allocation concealment and the review author does not find indirect evidence suggesting allocation concealment.

Criteria for the judgment of HIGH risk of bias:

Investigators interacting with participants could possibly foresee assignments and thus introduce bias, such as allocation based on: • Using an open random allocation schedule (e.g. a list of random numbers); or • Alternation or rotation; or • Non-random and known criteria, such as date of birth; or • Same study personnel performed sequence generation and administered initial treatment; or • Any other explicitly unconcealed procedure.

Page 3 of 13 B. Domains relevant to epidemiological studies only

1. Baseline differences (Are the study groups free from baseline differences?) Criteria for a judgment of LOW risk of bias:

There were no baseline differences among study groups or adjustment techniques were used to correct for the differences.

Examples of baseline differences: • Protocols for recruitment or inclusion/exclusion criteria were applied differently across study groups • Study participants were recruited at different times • Study participants were recruited from different populations and proportions of participants from each population in each study group are not uniform • Participation rates were inadequate or not comparable across study groups

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information about participant selection to permit a judgment of low risk of bias, but there is indirect evidence that suggests that participant recruitment and inclusion/exclusion criteria was consistent, as described by the criteria for a judgment of low risk of bias.

Criteria for the judgment of PROBABLY HIGH risk of bias:

There is insufficient information about participant selection to permit a judgment of high risk of bias, but there is indirect evidence that suggests that participant recruitment or inclusion/exclusion criteria was inconsistent, as described by the criteria for a judgment of high risk of bias.

Criteria for the judgment of HIGH risk of bias:

There were baseline differences among study groups and no adjustment was used to correct for the differences, such as: • Protocols for recruitment or inclusion/exclusion criteria were applied differently across study groups • Study participants were recruited at different times • Study participants were recruited from different populations and proportions of participants from each population in each study group are not uniform • Participation rates were inadequate or not comparable across study groups

Criteria for the judgment of NOT APPLICABLE (risk of bias domain is not applicable to study):

Page 4 of 13 There is evidence that participant selection is not an element of study design capable of introducing risk of bias in the study.

C. Domains relevant to both experimental and epidemiological studies

2. Blinding (Was knowledge of the exposure groups adequately prevented during the study?)

Criteria for a judgment of LOW risk of bias:

Any one of the following: • No blinding, but the review authors judge that the outcome and the outcome measurement are not likely to be influenced by lack of blinding; or • Blinding of key study personnel was ensured, and it is unlikely that the blinding could have been broken; or • Some key study personnel were not blinded, but outcome assessment was blinded and the non- blinding of others is unlikely to introduce bias.

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information about blinding to permit a judgment of low risk of bias, but there is indirect evidence that suggests the study was adequately blinded, as described by the criteria for a judgment of low risk of bias. For example, investigators were effectively blinded to the exposure and outcome groups, as the exposure was measured separately and the outcome was obtained from a hospital record.

Criteria for the judgment of PROBABLY HIGH risk of bias:

There is insufficient information about blinding to permit a judgment of high risk of bias, but there is indirect evidence that suggests the study was not adequately blinded, as described by the criteria for a judgment of high risk of bias.

Criteria for the judgment of HIGH risk of bias:

Any one of the following: • No blinding or incomplete blinding, and the outcome or outcome measurement is likely to be influenced by lack of blinding; or • Blinding of key study personnel attempted, but likely that the blinding could have been broken; or • Some key study personnel were not blinded, and the non-blinding of others likely to introduce bias.

Page 5 of 13

Criteria for the judgment of NOT APPLICABLE (risk of bias domain is not applicable to study):

There is evidence that blinding is not an element of study design capable of introducing risk of bias in the study.

3. Exposure assessment (Were exposure assessment methods robust?)

Criteria for a judgment of LOW risk of bias:

The reviewers judge that there is low risk of exposure misclassification and: • There is high confidence in the accuracy of the exposure assessment methods, such as direct measurements of external insecticide exposure levels, or biomarkers of internal insecticide dose that have been tested for validity and reliability in measuring the targeted compound(s); or • Less-established or less direct exposure measures are validated against direct measurements (as described above) AND, if direct measurements are used, appropriate QA/QC for methods are described and are satisfactory, with at least three of the following items reported, or at least two of the following items reported plus evidence of satisfactory performance in a high quality inter-laboratory comparison:

• Limit of detection or quantification; • standards recovery; • measure of repeatability; • investigation and prevention of blanks contamination.

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information about the exposure assessment methods to permit a judgment of low risk of bias, but there is indirect evidence that suggests that methods were robust, as described by the criteria for a judgment of low risk of bias. Studies only reporting that the QA/QC items above were satisfactory but not reporting all of the actual numbers may receive a judgment of “probably low risk of bias.”

Criteria for the judgment of PROBABLY HIGH risk of bias):

There is insufficient information about the exposure assessment methods to permit a judgment of high risk of bias, but there is indirect evidence that suggests that methods were not robust, as described by the criteria for a judgment of high risk of bias.

Criteria for the judgment of ‘NO’ (i.e. high risk of bias):

Page 6 of 13

The reviewers judge that there is high risk of exposure misclassification and any one of the following: • Uncertain how exposure information was obtained, or • There is low confidence in the accuracy of the exposure assessment methods; or • Less-established or less direct exposure measurements are not validated and are suspected to introduce bias that affects the outcome assessment. Examples: o Participants self-report exposure status, subject to recall bias. o Use of job titles and job tasks (whether self-reported or not) as surrogate measures of exposure. While such surrogate measures are unlikely to suffer from systematic misclassification, and as such will not be biased themselves, non-systematic misclassification of exposure is likely and will bias exposure-response relationships towards the null.

Criteria for the judgment of NOT APPLICABLE (risk of bias domain is not applicable to study):

There is evidence that exposure assessment methods are not capable of introducing risk of bias in the study.

4. Outcome assessment (Were outcome assessment methods robust?)

Criteria for a judgment of LOW risk of bias:

The reviewers judge that there is low risk of outcome misclassification and: • Outcomes were assessed and defined consistently across all study participants, using measurements of fasting plasma (or whole blood) glucose, oral glucose tolerance test, glycosylated hemoglobin A (HbA1c) or measurement of insulin production, o Optionally in combination with patient self-reported diabetes mellitus, • AND, if applicable, appropriate QA/QC for methods are described and are satisfactory.

As described elsewhere, studies relying solely on self-reported diagnosis of diabetes mellitus will not be included in the systematic review.

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information about the outcome assessment methods to permit a judgment of low risk of bias, but there is indirect evidence that suggests that methods were robust, as described by the criteria for a judgment of low risk of bias. Appropriate QA/QC for methods are not described but the review authors judge that the outcome and the outcome assessment are objective and uniform across study groups.

Page 7 of 13 Criteria for the judgment of PROBABLY HIGH risk of bias:

There is insufficient information about the outcome assessment methods to permit a judgment of high risk of bias, but there is indirect evidence that suggests that methods were not robust, as described by the criteria for a judgment of high risk of bias.

Criteria for the judgment of HIGH risk of bias:

The reviewers judge that there is high risk of outcome misclassification and any one of the following:

• There is low confidence in the accuracy of the outcome assessment methods; or • Uncertain how outcome information was obtained; or • The outcome was diabetes mellitus, based on register information.

Criteria for the judgment of NOT APPLICABLE (risk of bias domain is not applicable to study):

There is evidence that outcome assessment methods are not capable of introducing risk of bias in the study.

5. Confounding (Were confounding and effect modification adequately addressed?)

Depending on the specific type of diabetes mellitus studies, the following confounders will be considered important: • Type 1 diabetes mellitus: Ethnicity, HLA (Human Leukocyte Antigen) genotype or family history of diabetes mellitus. • Type 2, gestational and non-specified diabetes mellitus: Ethnicity, age, sex, family history of diabetes mellitus, diet, weight status and physical activity level.

Criteria for a judgment of LOW risk of bias:

The study appropriately assessed and accounted for (i.e., matched, stratified, multivariate analysis or otherwise statistically controlled for) important potential confounders, or reported that potential confounders were evaluated and omitted because inclusion did not substantially affect the results. The determination of specific confounders may be informed by, but not limited to, the studies included in the review. Potential interaction or effect modification was evaluated and adequately addressed. AND the important potential confounders and effect modifiers were measured consistently across study groups using valid and reliable methods.

Criteria for the judgment of PROBABLY LOW risk of bias:

The study accounted for most but not all of the important potential confounders and effect modifiers

Page 8 of 13 AND this lack of accounting is not expected to introduce substantial bias.

Criteria for the judgment of PROBABLY HIGH risk of bias:

The study accounted for some but not all of the important potential confounders and effect modifiers AND this lack of accounting may have introduced substantial bias.

Criteria for the judgment of HIGH risk of bias: The study did not account for or evaluate important potential confounders or effect modifiers. OR the important potential confounders and effect modifiers were not measured consistently across study groups using valid and reliable methods.

6. Incomplete outcome data (Were incomplete outcome data adequately addressed?)

Criteria for a judgment of LOW risk of bias:

Participants were followed long enough to obtain outcome measurements and: • No missing outcome data; or • Reasons for missing outcome data unlikely to be related to true outcome (for survival data, censoring unlikely to introduce bias); or • Attrition or missing outcome data balanced in numbers across exposure groups, with similar reasons for missing data across groups; or • For dichotomous outcome data, the proportion of missing outcomes compared with observed event risk not enough to have a relevant impact on the intervention effect estimate; or • For continuous outcome data, plausible effect size (difference in means or standardized difference in means) among missing outcomes not enough to have a relevant impact on the observed effect size; or • Missing data have been imputed using appropriate methods

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information about incomplete outcome data to permit a judgment of low risk of bias, but there is indirect evidence that suggests incomplete outcome data was adequately addressed, as described by the criteria for a judgment of low risk of bias.

Criteria for the judgment of PROBABLY HIGH risk of bias:

There is insufficient information about incomplete outcome data to permit a judgment of high risk of bias, but there is indirect evidence that suggests incomplete outcome data was not adequately addressed, as described by the criteria for a judgment of high risk of bias.

Page 9 of 13 Criteria for the judgment of HIGH risk of bias:

Participants were not followed long enough to obtain outcome measurements OR Any one of the following: • Reason for missing outcome data likely to be related to true outcome, with either imbalance in numbers or reasons for missing data across exposure groups; or • For dichotomous outcome data, the proportion of missing outcomes compared with observed event risk enough to induce biologically relevant bias in intervention effect estimate; or • For continuous outcome data, plausible effect size (difference in means or standardized difference in means) among missing outcomes enough to induce biologically relevant bias in observed effect size; or • Potentially inappropriate application of imputation.

Criteria for the judgment of NOT APPLICABLE (risk of bias domain is not applicable to study):

There is evidence that incomplete outcome data is not capable of introducing risk of bias in the study.

7. Selective outcome reporting (Are reports of the study free of suggestion of selective outcome reporting?)

Criteria for a judgment of LOW risk of bias:

All of the study’s pre-specified (primary and secondary) outcomes outlined in the protocol, methods, abstract, and/or introduction that are of interest in the review have been reported in the pre-specified way.

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information about selective outcome reporting to permit a judgment of low risk of bias, but there is indirect evidence that suggests the study was free of selective reporting, as described by the criteria for a judgment of low risk of bias.

Criteria for the judgment of PROBABLY HIGH risk of bias:

There is insufficient information about selective outcome reporting to permit a judgment of high risk of bias, but there is indirect evidence that suggests the study was not free of selective reporting, as described by the criteria for a judgment of high risk of bias.

Criteria for the judgment of HIGH risk of bias:

Page 10 of 13 Any one of the following: • Not all of the study’s pre-specified primary outcomes (as outlined in the protocol, methods, abstract, and/or introduction) have been reported; or • One or more primary outcomes is reported using measurements, analysis methods or subsets of the data (e.g. subscales) that were not pre-specified; or • One or more reported primary outcomes were not pre-specified (unless clear justification for their reporting is provided, such as an unexpected effect); or • One or more outcomes of interest are reported incompletely

Criteria for the judgment of NOT APPLICABLE (risk of bias domain is not applicable to study):

There is evidence that selective outcome reporting is not capable of introducing risk of bias in the study.

8. Conflict of interest (Was the study free from both financial and non-financial sources of potential conflicts of interest?) The International Committee of Medical Journal Editors (ICMJE) has published a widely used form for reporting potential conflicts of interests in scientific studies (http://www.icmje.org/conflicts-of-interest/, accessed 2019- 01-20). On the ICMJE form, study authors are requested to report four types of potential conflicts of interest. Excerpts from the form are listed below, along with selected examples of what could constitute such a conflict of interests.

1. "The work under consideration for publication": (...) "The requested information is about resources that you received, either directly or indirectly (via your institution), to enable you to complete the work." Examples: • Authors are employees of a company with a financial interest in the outcome of the study, or received any kind of support for the study from such (e.g., funding, design, conduct, analysis or reporting). Any companies within the agrochemical, agricultural or food industries will be considered to have a financial interest in study results. • Authors received grants specifically for the work in question (even if from government or other non-commercial sources).

2. "Relevant financial activities outside the submitted work": "This section asks about your financial relationships with entities in the bio-medical arena that could be perceived to influence, or that give the appearance of potentially influencing, what you wrote in the submitted work." (...) "Report all sources of revenue paid (or promised to be paid) directly to you or your institution over the 36 months prior to the submission of the work. Examples: • Grants for conference participation • Speaker or consultancy fees

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3. "Intellectual property": "This section asks about patents and copyrights, whether pending, issued, licensed and/or receiving royalties."

4. "Relationships not covered above": "(...) other relationships or activities that readers could perceive to have influenced, or that give the appearance of potentially influencing, what you wrote in the submitted work." Examples: • Authors are affiliated with entities with an interest in the outcome of the study, e.g. board membership in non-governmental organizations promoting organic farming. • Authors have participated in research training activities sponsored by agrochemical industry.

Criteria for a judgment of LOW risk of bias: Study authors make a claim denying both financial and non-financial conflicts of interests as outlined above, and no potential conflicts of interest are declared in other papers by the same authors, or identified from their curricula vitae.

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information to permit a judgment of low risk of bias, but there is indirect evidence to suggest this; or the only potential conflict of interests identified is funding from governments or other non-commercial sources without a clear financial or ideological interest in the study findings.

Criteria for the judgment of PROBABLY HIGH risk of bias: There is insufficient information to permit a judgment of high risk of bias, but there is indirect evidence that suggests the study might have been influenced by conflicts of interests, as described by the criteria for a judgment of high risk of bias.

Criteria for the judgment of HIGH risk of bias: Study authors have declared any financial or non-financial conflicts of interest as described in the ICMJE form; or a conflict of interest is declared in authors’ other articles or identified from their curricula vitae. Excepted are studies where the only potential conflict of interests is funding from sources without a clear financial or ideological interest in the findings – such studies will instead be categorized as “probably low risk or bias”, see above.

Criteria for the judgment of NOT APPLICABLE (risk of bias domain is not applicable to study):

There is evidence that conflicts of interest are not capable of introducing risk of bias in the study.

We will not consider it a source of risk of bias if stakeholders with financial interests in the study findings were involved in the problem formulation of the study, as long as they did not participate in or support the study in

Page 12 of 13 any other way. If we are in doubt about how to assess the risk of bias due to conflicts of interests in a study, non-disclosed conflicts of interest will be seen as more severe than disclosed ones.

9. Other bias (Was the study apparently free of other problems that could put it at a risk of bias?)

Criteria for a judgment of LOW risk of bias:

The study appears to be free of other sources of bias.

Criteria for the judgment of PROBABLY LOW risk of bias:

There is insufficient information to permit a judgment of low risk of bias, but there is indirect evidence that suggests the study was free of other threats to validity.

Criteria for the judgment of PROBABLY HIGH risk of bias:

There is insufficient information to permit a judgment of high risk of bias, but there is indirect evidence that suggests the study was not free of other threats to validity, as described by the criteria for a judgment of high risk of bias.

Criteria for the judgment of HIGH risk of bias: There is at least one important risk of bias. For example, the study: • Had a potential source of bias related to the specific study design used; or • Stopped early due to some data-dependent process (including a formal-stopping rule); or • The conduct of the study is affected by interim results (e.g. recruiting additional participants from a subgroup showing greater or lesser effect); or • Has been claimed to have been fraudulent; or • Had some other problem

To ensure consistent evaluation of all included studies, if we identify any “other” source of risk of bias in a single study, we will assess the entire evidence base for this potential source of bias.

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