AGING RESEARCH INSTITUTE NEWSLETTER Tabriz University of Medical Sciences Tabriz University of Medical Sciences (TUOMS)
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Volume 2/ Issue 1 JANUARY 2020 AGING RESEARCH INSTITUTE NEWSLETTER Tabriz University of Medical Sciences Tabriz University of Medical Sciences (TUOMS) Editorial We are delighted to offer our Message Bone loss in the craniofacial sincerest congratulations Dear colleagues and skeleton in geriatric patients friends at the Alavi center to our valued Christian in Tabriz! Tannaz Pourlak1 As we pass the winter sol- 1. Aging Research Institute, Tabriz University of colleagues and followers of stice and enter the last days of 2019, I Medical Sciences, Tabriz, Iran feel an urge to talk about the loss of the Email: [email protected] Jesus Christ, the prophet Tel: +989143116175 real world and its replacement with a Fax: +984133352078 of peace and kindness, on virtual world. The advent of the internet new year. We hope that and the subsequent introduction of so- Age-related bone loss has been little stud- cial media, along with the loss of written ied in the craniofacial skeleton exceptions the coming year will be books and printed papers, contributed to of the mandible and the maxilla. Consist- full of success, prosperity, the plunge of humanity into an artificial ent with the importance of the mandible world that exists only in people’s heads and maxilla in mastication and facial ap- and peace for all nations. and in the computers where the digitized pearance, a lot of studies focus on these We wish you a year full of instructions reside with little similarity to bones. However, because of edentulism or affinity with the world that they mimic. and periodontal disease, two commonly happiness and health. If visitors from an alien world were to encountered conditions that can inde- Happy 2020. come upon the earth at a time in the fu- pendently cause bone loss, the mandible ture when all computers and networks and maxilla have also proved to be in- Sketch: Ali Shamekh, Medical Student of TUOMS had been turned off, as in The Second volved in complex situations of aging-as- Sleep, they would have no chance to im- sociated osteopenia. Tooth loss causes to Biography: Prof. Soodabeh Davaran agine the images that these machines localized bone loss, for the reason that it once invoked in the observers of the eradicates a source of mechanical load- screens and pads and readers when ing and maybe stem cells and growth the devices were active. The interesting factors (in the periodontium) are main in question is whether the visiting aliens sustaining bone mass, predominantly in would be able to make sense of the in- the alveolar bone that surrounds the tooth structions and feed them accurately to roots. the machines that they had somehow However, the consensus of most stud- managed somehow to turn on. ies is that there is a naturally happening The dilemma reminds me of the issue of age-related loss of alveolar bone that what the world would be like if humans or arises independently of edentulism and other potential observers were not there periodontal disease. Furthermore, there to interpret the signals. Even the ques- looks to be a positive association between tion itself of what it would be “like” would osteoporosis in the postcranial skeleton be meaningless if no one were present and the osteopenia that happens in the to interpret the signals. This may happen alveolus [1]. Wactawski-Wende et al. [2] in the future but has not happened yet. compared the risk (odds ratio; OR) of loss Fortunately, there is still time during the of alveolar bone with the severity of loss Professor Soodabeh Davaran was born in 1965 in Tabriz, Iran. She received current turning of the wheel of years to in bone mineral density in another place in her PhD in Polymer Chemistry (Pharmaceutical Biomaterial) in 1996 from safely indulge in the admiration of the the body. The data display that the greater Tabriz University and getting her professor rank in chemistry department in world itself and ponder these philosoph- the systemic osteoporosis, the higher the 2008 from the Faculty of Pharmacy at the Tabriz University of Medical Scienc- ical questions, even without the aid of risk of alveolar bone loss. For example, es (TUOMS). At present, she is the head of nanomedicine department in the internet and networks and social media, after adjustment for different co-factors School Of Advanced Medical Sciences, TUOMS. Professor Davaran has pub- other than those our brains are equipped containing age, weight, hormone use and lished about 200 papers in international journals. She has also registered 15 with, courtesy of the generosity of evolu- education, the OR for alveolar crest bone national patents in the field of novel drug delivery systems and nanomedicine. tion and Nature, whomever she or he or loss for an osteoporotic woman (T score She has supervised more than 60 thesis in the field of pharmacy, nanotechnol- it is. <−2.5) aging 70 years or older is about ogy, and biomaterial. She has the highest h index among the female academic The word “wheel” of the wheel of years 3.6[2]. staff in the northwest of Iran. The fields of her research include biomaterial is “hjul” in Danish that also gave rise to As stated by a correlation between the development for drug delivery systems in particular anticancer therapies and the word “jul” for solstice or “Yule” in degree of systemic osteopenia or osteo- tissue engineering especially skin, bone, and cartilage. English, a word that is equally useful to porosis and the loss of alveolar bone, it is She has been involved in the establishment of two research center and set all inhabitants of the world, regardless of not surprising that hormone replacement up of three laboratories at Medical Institute of Tabriz University of Medical which of the many past, present or future therapy (HRT) is efficient in curtailing Sciences. At present, she is the head of nanomedicine department in the Fac- events and changes at the times of the bone loss in both circumstances. ulty of Advanced Medical Sciences. She is the advisor of the East Azerbaijan solstices we focus on as individuals or In a double-blinded, placebo controlled Province Governor-General in research and development of women’s affairs. as members of diverse groups. As such, trial done by Civitelli et al. [3] postmeno- In recent years, she has been awarded several prizes. She is also a member of jul or Yule refers to the general solstice, pausal women with no evidence of mod- the editorial board of three scientific journals and a member of the American whether Winter or Summer, depending erate or severe periodontal disease were Chemical Society. Some of her national and international achievements are as on where you live. It is everywhere the treated with conjugated oestrogen (alone follows: season for giving and receiving and re- or in combination with medroxyproges- • The UNESCO Medal for development of Nanosciences and Nanotechnolo- membering, unaided by mindless com- terone) or placebo, and were followed gies. puters, and bringing to mind the togeth- for three years. The results displayed that • First rank in National Razi Festival in Basic Sciences among more than 60 erness that we as humankind depend on. HRT increased alveolar bone mass and universities of medical sciences. Therefore, this letter is for you! perhaps height in parallel with increases • Entitled as “Women Elites of Iran and All Elites around the Islamic World”. May you all enjoy a merry yuletide and a in postcranial bone density in the femur. • Selected as “The world’s top scientist by International biographical canter of happy new turn of the wheel! As noted above, although oral bone loss Cambridge”. Prof. Albert Gjedde arises in most individuals as a part [Cont.] • Top Researcher in Tabriz University of Medical Sciences. 1 2 3 4 5 6 7 8 Editorial Biography Messages The International Mini Review Top Article Student Letter International Healthy Aging Projects Network (iHAN) 1 Volume 2/ Issue 1 AGING RESEARCH INSTITUTE NEWSLETTER JANUARY 2020 Editorial [cont.] of the aging process, the loss of teeth method for maintaining alveolar bone the craniofacial skeleton in geriatric patients. Ag- cranial bone density in postmenopausal women re- remains a very significant factor in de- seems to be the dental implant, provided ing research institute newsletter. 2020 Jan; 2 (1):1 ceiving hormone/estrogen replacement therapy: a References: randomized, double-blind, placebo-controlled trial. termining the extent and location of oral that the associated restoration lets for 1. Jeffcoat, M. (2005) The association between os- Archives of Internal Medicine, 162, 1409–1415. osteopenia. After the loss of teeth, there balanced occlusal loading on mastica- teoporosis and oral bone loss. Journal of Periodon- 4. Bodic, F., Hamel, L., Lerouxel, E., Baslé, M.F. & is an accelerated resorption of residual tion and that following care controls per- tology, 76(Suppl 11), 2125–2132. Chappard, D. (2005) Bone loss and teeth. Joint, 2. Wactawski-Wende, J., Hausmann, E., Hovey, K., Bone, Spine, 72, 215–221. alveolar bone that keep on for numer- iodontal disease at the implant site. Trevisan, M.,Grossi, S. & Genco, R.J. (2015) The 5. Kingsmill, V.J. (2011) Post-extraction remodeling ous months followed by a slower rate of association between osteoporosis and alveolar of the adult mandible. Critical Reviews in Oral Biol- localized osteopenia that may continue Received: 26 October 2019 crestal height in postmenopausal women. Journal ogy & Medicine, 10, 384–404. of Periodontology, 76(Suppl 11), 2116–2124. 6. Wyatt, C.C. (2010) The effect of prosthodontic for many years, even in the existence Revised: 20 November 2019 Accepted: 7 December 2019 3. Civitelli, R., Pilgram, T.K., Dotson, M., Mucker- treatment on alveolar bone loss: a review of the literature.