RESEARCH ARTICLE SERPINE2 Inhibits IL-1α-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-κB/AP-1 Pathways Anna Santoro1,3☯, Javier Conde1☯, Morena Scotece1, Vanessa Abella1,2, Ana Lois1, Veronica Lopez1, Jesus Pino4, Rodolfo Gomez1, Juan J. Gomez-Reino5, Oreste Gualillo1* 1 SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), the NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain, 2 Department of Molecular and Cellular Biology, University of Coruña (UDC), A Coruña, Spain, 3 University of Naples Federico II, Dept. of Pharmacy, 80138, Naples, Italy, 4 SERGAS (Servizo Galego de Saude), Division of Orthopaedics Surgery and Traumatology, Santiago University Clinical Hospital, Santiago de Compostela, Spain, 5 University of Santiago de Compostela, Department of Medicine and SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), Division of Rheumatology, Santiago University Clinical Hospital, Santiago de Compostela, Spain ☯ These authors contributed equally to this work. OPEN ACCESS *
[email protected] Citation: Santoro A, Conde J, Scotece M, Abella V, Lois A, Lopez V, et al. (2015) SERPINE2 Inhibits IL- 1α-Induced MMP-13 Expression in Human Abstract Chondrocytes: Involvement of ERK/NF-κB/AP-1 Pathways. PLoS ONE 10(8): e0135979. doi:10.1371/ journal.pone.0135979 Objectives Editor: Fulvio d'Acquisto, Queen Mary University of Osteoarthritis (OA) is a chronic joint disease, characterized by a progressive loss of articular London, UNITED KINGDOM cartilage. During OA, proinflammatory cytokines, such as interleukin IL-1, induce the Received: May 20, 2015 expression of matrix metalloproteinases (MMPs) in chondrocytes, contributing thus to the Accepted: July 28, 2015 extracellular matrix (ECM) degradation.