Rita Levi-Montalcini
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James D. Watson Molecular Biologist, Nobel Laureate ( 1928 – )
James D. Watson Molecular biologist, Nobel Laureate ( 1928 – ) Watson is a molecular biologist, best known as one of the co-discoverers of the struc- ture of DNA. Watson, Francis Crick, and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine. Watson was born in Chicago, and early on showed his brilliance, appearing on Quiz Kids, a popular radio show that challenged precocious youngsters to answer ques- tions. Thanks to the liberal policy of University of Chicago president ROBERT HUTCHINS, Watson was able to enroll there at the age of 15, earning a B.S. in Zoology in 1947. He was attracted to the work of Salvador Luria, who eventually shared a Nobel Prize with Max Delbrück for their work on the nature of genetic mutations. In 1948, Watson began research in Luria’s laboratory and he received his Ph.D. in Zoology at Indiana University in 1950 at age 22. In 1951, the chemist Linus Pauling published his model of the protein alpha helix, find- ings that grew out of Pauling’s relentless efforts in X-ray crystallography and molecu- lar model building. Watson now wanted to learn to perform X-ray diffraction experi- ments so that he could work to determine the structure of DNA. Watson and Francis Crick proceeded to deduce the double helix structure of DNA, which they submitted to the journal Nature and was subsequently published on April 25, 1953. Watson subsequently presented a paper on the double helical structure of DNA at the Cold Spring Harbor Symposium on Viruses in early June 1953. -
Jewels in the Crown
Jewels in the crown CSHL’s 8 Nobel laureates Eight scientists who have worked at Cold Max Delbrück and Salvador Luria Spring Harbor Laboratory over its first 125 years have earned the ultimate Beginning in 1941, two scientists, both refugees of European honor, the Nobel Prize for Physiology fascism, began spending their summers doing research at Cold or Medicine. Some have been full- Spring Harbor. In this idyllic setting, the pair—who had full-time time faculty members; others came appointments elsewhere—explored the deep mystery of genetics to the Lab to do summer research by exploiting the simplicity of tiny viruses called bacteriophages, or a postdoctoral fellowship. Two, or phages, which infect bacteria. Max Delbrück and Salvador who performed experiments at Luria, original protagonists in what came to be called the Phage the Lab as part of the historic Group, were at the center of a movement whose members made Phage Group, later served as seminal discoveries that launched the revolutionary field of mo- Directors. lecular genetics. Their distinctive math- and physics-oriented ap- Peter Tarr proach to biology, partly a reflection of Delbrück’s physics train- ing, was propagated far and wide via the famous Phage Course that Delbrück first taught in 1945. The famous Luria-Delbrück experiment of 1943 showed that genetic mutations occur ran- domly in bacteria, not necessarily in response to selection. The pair also showed that resistance was a heritable trait in the tiny organisms. Delbrück and Luria, along with Alfred Hershey, were awarded a Nobel Prize in 1969 “for their discoveries concerning the replication mechanism and the genetic structure of viruses.” Barbara McClintock Alfred Hershey Today we know that “jumping genes”—transposable elements (TEs)—are littered everywhere, like so much Alfred Hershey first came to Cold Spring Harbor to participate in Phage Group wreckage, in the chromosomes of every organism. -
Happy Birthday to Renato Dulbecco, Cancer Researcher Extraordinaire
pbs.org http://www.pbs.org/newshour/updates/happy-birthday-renato-dulbecco-cancer-researcher-extraordinaire/ Happy birthday to Renato Dulbecco, cancer researcher extraordinaire Photo of Renato Dulbecco (public domain) Every elementary school student knows that Feb. 22 is George Washington’s birthday. Far fewer (if any) know that it is also the birthday of the Nobel Prize-winning scientist Renato Dulbecco. While not the father of his country — he was born in Italy and immigrated to the United States in 1947 — Renato Dulbecco is credited with playing a crucial role in our understanding of oncoviruses, a class of viruses that cause cancer when they infect animal cells. Dulbecco was born in Catanzaro, the capital of the Calabria region of Italy. Early in his childhood, after his father was drafted into the army during World War I, his family moved to northern Italy (first Cuneo, then Turin, and thence to Liguria). A bright boy, young Renato whizzed through high school and graduated in 1930 at the age of 16. From there, he attended the University of Turin, where he studied mathematics, physics, and ultimately medicine. Dulbecco found biology far more fascinating than the actual practice of medicine. As a result, he studied under the famed anatomist, Giuseppe Levi, and graduated at age 22 in 1936 at the top of his class with a degree in morbid anatomy and pathology (in essence, the study of disease). Soon after receiving his diploma, Dr. Dulbecco was inducted into the Italian army as a medical officer. Although he completed his military tour of duty by 1938, he was called back in 1940 when Italy entered World War II. -
Renato Dulbecco
BIOLOGIE ET HISTOIRE Renato Dulbecco Renato Dulbecco : de la virologie à la cancérologie F.N.R. RENAUD 1 résumé Né en Italie, Renato Dulbecco fait de brillantes études médicales mais est plus intéressé par la recherche en biologie que par la pratique médicale. Accueilli par Giuseppe Levi, il apprend l’histologie et la culture cellulaire avant de rejoindre le laboratoire de S.E. Luria puis celui de M. Delbrück pour travailler sur les systèmes bactéries-bactériophages puis sur la relation cellules-virus. Il met au point la méthode des plages de lyse virales sur des cultures cellulaires. Il est aussi à l’origine de la virologie tumorale moléculaire. D. Baltimore, HM Temin et lui-même sont récompensés par le prix Nobel de médecine et physiologie en 1975 pour leurs travaux sur l'interaction entre les virus tumoraux et le matériel génétique du matériel cellulaire. Très tourné vers les aspects pratiques et expérimentaux de la recherche, il est resté le plus long - temps possible à la paillasse et a initié un très grand nombre de jeunes chercheurs. mots-clés : culture cellulaire, virologie tumorale, plages de lyse, bactériophages. I. - LA JEUNESSE DE RENATO DULBECCO C'est à Catanzaro, capitale régionale de la Calabre en Italie, que naît Renato Dulbecco le 22 février 1914. Sa mère est Calabraise et son père Ligurien. Il ne reste que très peu de temps dans le sud de l’Italie, car son père est mobilisé et sa famille doit déménager dans le nord à Cuneo, puis à Turin. À la fin de la guerre, la famille Dulbeco s'ins - talle à Imperia en Ligurie. -
The Eighth Day of Creation”: Looking Back Across 40 Years to the Birth of Molecular Biology and the Roots of Modern Cell Biology
“The Eighth Day of Creation”: looking back across 40 years to the birth of molecular biology and the roots of modern cell biology Mark Peifer1 1 Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA * To whom correspondence should be addressed Email: [email protected] Phone: (919) 962-2272 1 Forty years ago, Horace Judson’s “The Eight Day of Creation” was published, a book vividly recounting the foundations of modern biology, the molecular biology revolution. This book inspired many in my generation. The anniversary provides a chance for a new generation to take a look back, to see how science has changed and hasn’t changed. Many central players in the book, including Sydney Brenner, Seymour Benzer and Francois Jacob, would go on to be among the founders of modern cell, developmental, and neurobiology. These players come alive via their own words, as complex individuals, both heroes and anti-heroes. The technologies and experimental approaches they pioneered, ranging from cell fractionation to immunoprecipitation to structural biology, and the multidisciplinary approaches they took continue to power and inspire our work today. In the process, Judson brings out of the shadows the central roles played by women in many of the era’s discoveries. He provides us with a vision of how science and scientists have changed, of how many things about our endeavor never change, and how some new ideas are perhaps not as new as we’d like to think. 2 In 1979 Horace Judson completed a ten-year project about cell and molecular biology’s foundations, unveiling “The Eighth Day of Creation”, a book I view as one of the most masterful evocations of a scientific revolution (Judson, 1979). -
Balcomk41251.Pdf (558.9Kb)
Copyright by Karen Suzanne Balcom 2005 The Dissertation Committee for Karen Suzanne Balcom Certifies that this is the approved version of the following dissertation: Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine Committee: E. Glynn Harmon, Supervisor Julie Hallmark Billie Grace Herring James D. Legler Brooke E. Sheldon Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine by Karen Suzanne Balcom, B.A., M.L.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August, 2005 Dedication I dedicate this dissertation to my first teachers: my father, George Sheldon Balcom, who passed away before this task was begun, and to my mother, Marian Dyer Balcom, who passed away before it was completed. I also dedicate it to my dissertation committee members: Drs. Billie Grace Herring, Brooke Sheldon, Julie Hallmark and to my supervisor, Dr. Glynn Harmon. They were all teachers, mentors, and friends who lifted me up when I was down. Acknowledgements I would first like to thank my committee: Julie Hallmark, Billie Grace Herring, Jim Legler, M.D., Brooke E. Sheldon, and Glynn Harmon for their encouragement, patience and support during the nine years that this investigation was a work in progress. I could not have had a better committee. They are my enduring friends and I hope I prove worthy of the faith they have always showed in me. I am grateful to Dr. -
Export / Import: the Promotion of Contemporary Italian Art in the United States, 1935–1969
City University of New York (CUNY) CUNY Academic Works All Dissertations, Theses, and Capstone Projects Dissertations, Theses, and Capstone Projects 2-2016 Export / Import: The Promotion of Contemporary Italian Art in the United States, 1935–1969 Raffaele Bedarida Graduate Center, City University of New York How does access to this work benefit ou?y Let us know! More information about this work at: https://academicworks.cuny.edu/gc_etds/736 Discover additional works at: https://academicworks.cuny.edu This work is made publicly available by the City University of New York (CUNY). Contact: [email protected] EXPORT / IMPORT: THE PROMOTION OF CONTEMPORARY ITALIAN ART IN THE UNITED STATES, 1935-1969 by RAFFAELE BEDARIDA A dissertation submitted to the Graduate Faculty in Art History in partial fulfillment of the requirements for the degree of Doctor of Philosophy, The City University of New York 2016 © 2016 RAFFAELE BEDARIDA All Rights Reserved ii This manuscript has been read and accepted for the Graduate Faculty in Art History in satisfaction of the Dissertation requirement for the degree of Doctor of Philosophy ___________________________________________________________ Date Professor Emily Braun Chair of Examining Committee ___________________________________________________________ Date Professor Rachel Kousser Executive Officer ________________________________ Professor Romy Golan ________________________________ Professor Antonella Pelizzari ________________________________ Professor Lucia Re THE CITY UNIVERSITY OF NEW YORK iii ABSTRACT EXPORT / IMPORT: THE PROMOTION OF CONTEMPORARY ITALIAN ART IN THE UNITED STATES, 1935-1969 by Raffaele Bedarida Advisor: Professor Emily Braun Export / Import examines the exportation of contemporary Italian art to the United States from 1935 to 1969 and how it refashioned Italian national identity in the process. -
Jewish Nobel Prize Laureates
Jewish Nobel Prize Laureates In December 1902, the first Nobel Prize was awarded in Stockholm to Wilhelm Roentgen, the discoverer of X-rays. Alfred Nobel (1833-96), a Swedish industrialist and inventor of dynamite, had bequeathed a $9 million endowment to fund significant cash prizes ($40,000 in 1901, about $1 million today) to those individuals who had made the most important contributions in five domains (Physics, Chemistry, Physiology or Medicine, Literature and Peace); the sixth, in "Economic Sciences," was added in 1969. Nobel could hardly have imagined the almost mythic status that would accrue to the laureates. From the start "The Prize" became one of the most sought-after awards in the world, and eventually the yardstick against which other prizes and recognition were to be measured. Certainly the roster of Nobel laureates includes many of the most famous names of the 20th century: Marie Curie, Albert Einstein, Mother Teresa, Winston Churchill, Albert Camus, Boris Pasternak, Albert Schweitzer, the Dalai Lama and many others. Nobel Prizes have been awarded to approximately 850 laureates of whom at least 177 of them are/were Jewish although Jews comprise less than 0.2% of the world's population. In the 20th century, Jews, more than any other minority, ethnic or cultural, have been recipients of the Nobel Prize. How to account for Jewish proficiency at winning Nobel’s? It's certainly not because Jews do the judging. All but one of the Nobel’s are awarded by Swedish institutions (the Peace Prize by Norway). The standard answer is that the premium placed on study and scholarship in Jewish culture inclines Jews toward more education, which in turn makes a higher proportion of them "Nobel-eligible" than in the larger population. -
Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research
A Service of Leibniz-Informationszentrum econstor Wirtschaft Leibniz Information Centre Make Your Publications Visible. zbw for Economics Hollingsworth, Joseph Rogers Working Paper Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research WZB Discussion Paper, No. P 02-003 Provided in Cooperation with: WZB Berlin Social Science Center Suggested Citation: Hollingsworth, Joseph Rogers (2002) : Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research, WZB Discussion Paper, No. P 02-003, Wissenschaftszentrum Berlin für Sozialforschung (WZB), Berlin This Version is available at: http://hdl.handle.net/10419/50229 Standard-Nutzungsbedingungen: Terms of use: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Documents in EconStor may be saved and copied for your Zwecken und zum Privatgebrauch gespeichert und kopiert werden. personal and scholarly purposes. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle You are not to copy documents for public or commercial Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich purposes, to exhibit the documents publicly, to make them machen, vertreiben oder anderweitig nutzen. publicly available on the internet, or to distribute or otherwise use the documents in public. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, If the documents have been made available under an Open gelten abweichend von diesen Nutzungsbedingungen die in der dort Content Licence (especially Creative Commons Licences), you genannten Lizenz gewährten Nutzungsrechte. may exercise further usage rights as specified in the indicated licence. www.econstor.eu P 02 – 003 RESEARCH ORGANIZATIONS AND MAJOR DISCOVERIES IN TWENTIETH-CENTURY SCIENCE: A CASE STUDY OF EXCELLENCE IN BIOMEDICAL RESEARCH J. -
Uncannily Real Italian Painting of the 1920S 28 September 2018 – 13 January 2019 Opening: 27 September, 7 P.M
Press materials Uncannily Real Italian Painting of the 1920s 28 September 2018 – 13 January 2019 Opening: 27 September, 7 p.m. Content 1. Press release 2. Biographies – a selection 3. Wall texts 4. General information 5. Catalogue 6. Press images 7. Fact sheet Museum Folkwang Press Release Uncannily Real – a major special exhibition on Italian painting of the 1920s on display at Museum Folkwang from 28 September. Essen, 27.9.2018 – The exhibition Uncannily Real: Italian Painting of the 1920s presents more than 80 paintings from Realismo Magico. This artistic movement emerged in Italy in the wake of the First World War, parallel to Neue Sachlichkeit in Germany. Outstanding works by key protagonists such as Felice Casorati, Antonio Donghi and Ubaldo Oppi are featured alongside influential paintings by Giorgio de Chirico and Carlo Carrà. This represents the first comprehensive presentation of these works in Germany, allowing visitors to rediscover this strand of Modernism. After the experiences of the First World War, in Europe and beyond, many artists returned to a realistic form of representation, definitively abandoning Expressionism. Picking up on the metaphysical painting of Giorgio de Chirico and Carlo Carrà and the rappel à l’ordre (call for a return to order) issued by Parisian Neo-Classicism, the artists cause time to stand still in their paintings. They imbue their realistic depictions with dream-like, uncanny, at times disturbing elements. The paintings depict their subject matter clearly and precisely, while retaining a cryptic quality to their atmospheres and themes. The result is the production of evocative works of outstanding painterly quality, often in dazzling colours. -
Salvador Luria and Max Delbrück on Random Mutation and Fluctuation Tests
| CLASSIC Salvador Luria and Max Delbrück on Random Mutation and Fluctuation Tests Andrew Murray1 Molecular and Cellular Biology and Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138 ORIGINAL CITATION Mutations of Bacteria from Virus Sensitivity to Virus Resistance Salvador Edward Luria and Max Delbrück GENETICS November 20, 1943 28: 491–511 o mutations arise randomly over time? Or are they induced The Luria–Delbrück article had three important impacts Dby unfavorable environments? By addressing these crucial beyond its direct conclusion: it showed that elegant statistical evolutionary questions, Salvador Luria and Max Delbrück won a analysis could illuminate biological processes that could not NobelPrizeandhelpedtostartthefield of bacterial genetics. be directly observed, it contributed to Luria and Delbrück In 1943, it had long been known that bacterial cultures winning the 1969 Nobel Prize in Medicine or Physiology rapidly develop resistance to viral infection. Some biologists (shared with Alfred Hershey), and it led, indirectly, to a con- argued that viruses directly induced resistance mutations, tinuing debate about whether organisms exert physiological while others believed the mutations arose spontaneously control over their mutation rates. before exposure to the virus. But when Luria and Delbrück Communicating editor: C. Gelling first attempted to distinguish between these two hypotheses, they were frustrated by what appeared to be irritatingly in- consistent mutation rates. Then, after watching a colleague Further Reading in GENETICS win a jackpot ($3 in dimes!) at a slot machine, Luria realized Bertani, G., 1992 Salvador Edward Luria (1912–1991). Genetics this inconsistency was telling him something: the number of 131: 1–4. -
Michela Scolaro Felice Casorati. Note Biografiche
Michela Scolaro Felice Casorati. Note biografiche “La mia vita non è intessuta di avvenimenti straordinari che possano pingo delle povere vecchie con i loro vecchi scialli sbiaditi e il fardello dei lo- suggerirmi una favola interessante e i fatti che sono stati per me di grande ro dolori, dei loro ricordi” (lettera a Tersilla Guadagnini, 19 dicembre). Alla importanza parrebbero a Voi, se ve li palesassi, insignificanti e banali. II Quadriennale di Torino espone il Ritratto di Don Pedro de Consedo. Questa reticenza che provo a parlare di me, parrebbe derivare da uno Trascorre il maggio del 1909 a Firenze, un soggiorno di studio che gli consen- scarso amore per me stesso … il pittore manifesta questo amore dipingendo te di allontanarsi dalla poco congeniale atmosfera partenopea. Invitato a spesso e volentieri il proprio ritratto e facendo apparire i propri tratti nelle esporre a Venezia, presenta Le vecchie e Le figlie dell’attrice. Con Vecchie co- figure dei suoi quadri. Ebbene io non ho mai dipinto un autoritratto e non mari, partecipa all’Esposizione nazionale di Rimini. È presente, inoltre, alla mi sembra che le figure dei miei quadri mi rassomiglino…”1. mostra romana della Società Amatori e Cultori. Al termine della manifesta- zione la Galleria d’Arte Moderna compera Le vecchie. I luoghi e i tempi Le ereditiere lo rappresenta alla Biennale del 1910, edizione anticipata per Novara, 4 dicembre 1883. Felice nasce da Carolina Borgarelli, d’origine ver- non coincidere con le celebrazioni romani del Cinquantesimo dell’Unità cellese, e da Francesco, pavese, militare di carriera e pittore dilettante.