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Uva-DARE (Digital Academic Repository) UvA-DARE (Digital Academic Repository) Mycobacterium tuberculosis and human immunodeficiency virus type 1 interaction: Pathogenesis and disease modulation in dual infection Mayanja-Kizza, H. Publication date 2014 Link to publication Citation for published version (APA): Mayanja-Kizza, H. (2014). Mycobacterium tuberculosis and human immunodeficiency virus type 1 interaction: Pathogenesis and disease modulation in dual infection. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:30 Sep 2021 Europe (Netherlands, Germany, Sweden, European-Developing Country Trials Partnership) as Acknowledgements well as North America (USA, Canada). I owe my gratitude to the numerous persons who have contributed towards this work, my training She continues her research activities specifically in the areas of tuberculosis immune- and career over the years. pathogenesis, vaccine trials preparation, tuberculosis biomarkers and clinical trials as well as The patients and persons in Uganda who have participated in this research, specifically at Mulago malaria immunology, with rapid tuberculosis immune-diagnosis as a major area of focus. She hospital, the tuberculosis wards and clinics, The AIDS Support Organization, AIDS Information continues to supervise and mentor junior and mid level researchers, as well as steer the Makerere Center, Infectious Disease Institute, Kampala City Council Clinics and the Kawempe division University School of Medicine to further growth and development community as a whole. These patients and persons who willingly contributed towards this work for the benefit of human kind are highly appreciated. Mentors are an important aspect of career development, and my gratitude to my many mentors. Prof Roy Mugerwa for his guidance and encouragement towards the discipline of immunology. He was always willing to listen and advise me, sometimes pushing me beyond my own expectations. Prof Jerry Ellner, from the time I met him on the steps of the tuberculosis clinics in 1993, he believed in me, encouraged me, and provided guidance in research. He has always been available to offer advice and listen to my thoughts and provide invaluable ideas and direction. He offered me an opportunity towards my initial training and research in immunology; providing me the option of using resources at the Tuberculosis Research Unit and immunology laboratories at Case Western Reserve University as well as the Uganda research laboratories. My utmost gratitude goes to Prof Zahra Toossi. She introduced me to laboratory work and gently guided me in the initial stages where I seemed to be making more errors than progress. She was tolerant when I repeated experiments over and over again, guided me in scientific writing and thinking, always prodding and encouraging me to do more. I owe a great part of this work to her support, guidance, motivation and encouragement. Prof Christopher Whalen for the opportunity he offered me as an AIDS International Training and Research Program (AITRP) Fogarty scholar to train at Case Western Reserve University (CWRU). He set the pace for this work. After my Masters in immunology, he encouraged me to continue with research and training. Prof Henry Boom; who provided guidance to me since the time of my Master’s studies. He was my dissertation supervisor who progressed to become a colleague in tuberculosis immunology research. He always believed in me as a person and the Ugandan people as a whole – reminding others that Ugandans are okay; they always deliver as needed. Thank you for supporting my research and academic career up to this time. 122 123 Prof John Johnson with his meticulous work approach and emphasis to detail, especially as I to develop academically, publish and conduct relevant research, treating every new publication gained skills in tuberculosis clinical trials. I have learnt a lot from him in optimal and methodical as a success of not only the individual but the College of Health Sciences, and Makerere management of tuberculosis clinical trials and how to always strive for perfection. university a whole. I am grateful to the various persons who assisted and trained me in both immunology assays and Lastly my utmost gratitude goes to my husband Dr Ian Kizza and children Diana, Doreen, Keith, research principles. Dr Christina Hirsch who taught me various assays in the laboratory, and lead Kevin and Jonathan. Ian has always shared in the joy of my successes, and encouraged me on me to always aim for top quality work; Dr Hai Shao, Dr Theresa Hertgho - I thank you all Mr. towards the next step; the children for their tolerance as we all moved together along the Pierre Peters for his support and patience as he trained me in the early days of bench work. He academic path albeit at different levels. My siblings for their humorous closely knit relationship. would willingly stay behind after working hours to guide and assist me complete assays and My parents Mr. Morrison and Mrs. Ida Mayanja – from the beginning they instilled in us helped in various aspects in the Uganda Joint clinical Research center (JCRC) immunology children the importance of education, something they considered as a major key to our future research laboratory. I am grateful to Ms Joy Baseke for her support over the years in the JCRC success. I dedicate this doctorate to both of them – they always knew I would make it. Thank you laboratory. for all. Prof Stephan Kaufmann at the Max Planck Institute for Infection Biology (MPIIB) in Berlin, for all that I have learnt from him in the area of tuberculosis biomarkers and related research. Prof Gerhard Walzl at Stellenbosch University (SUN) and Prof Willem Hanekom at the University of Cape Town I have learnt a lot from both of you, and your interaction has boosted my confidence especially- at times when I needed this moral boost. The various colleagues and staff at the Uganda Case research clinic; Dr Alphonse Okwera, Dr Anne Wajja, Dr Henry Luzze, Dr Mary Nsereko, the nurses, counselors, home visitors, administrators and all the staff over the years. Their support and help has been invaluable and highly appreciated. My utmost gratitude to Prof Joep Lange for the encouragement you gave me towards starting and completing this work. My appreciation also goes to the staff at the Amsterdam Institute for- Global Health and Development (AIGHD) foundation, the Academic Medical Center and the University of Amsterdam for all the support and cooperation. It was at the INTERACT meeting in Kigali, Rwanda where Nadine Pakkar and Kimberly Boer first mooted the idea of doctoral studies to me; the seed was planted and well watered to fuitation; thank you. I cannot forget my “sparring partners” colleagues with whom we have held discussions compared notes and encouraged each other over the years including Prof Moses Kamya, Prof Elly Katabira, Prof David Serwadda, Prof Fred Wabwire, Prof Phillipa Musoke and others. Prof Nelson Sewankambo, who has always given us space to develop while keeping his “finger on the pulse” he believed in, and encouraged all at the Makerere College of Health Sciences (MakCHS) 124 125 Prof John Johnson with his meticulous work approach and emphasis to detail, especially as I to develop academically, publish and conduct relevant research, treating every new publication gained skills in tuberculosis clinical trials. I have learnt a lot from him in optimal and methodical as a success of not only the individual but the College of Health Sciences, and Makerere management of tuberculosis clinical trials and how to always strive for perfection. university a whole. I am grateful to the various persons who assisted and trained me in both immunology assays and Lastly my utmost gratitude goes to my husband Dr Ian Kizza and children Diana, Doreen, Keith, research principles. Dr Christina Hirsch who taught me various assays in the laboratory, and lead Kevin and Jonathan. Ian has always shared in the joy of my successes, and encouraged me on me to always aim for top quality work; Dr Hai Shao, Dr Theresa Hertgho - I thank you all Mr. towards the next step; the children for their tolerance as we all moved together along the Pierre Peters for his support and patience as he trained me in the early days of bench work. He academic path albeit at different levels. My siblings for their humorous closely knit relationship. would willingly stay behind after working hours to guide and assist me complete assays and My parents Mr. Morrison and Mrs. Ida Mayanja – from the beginning they instilled in us helped in various aspects in the Uganda Joint clinical Research center (JCRC) immunology children the importance of education, something they considered as a major key to our future research laboratory. I am grateful to Ms Joy Baseke for her support over the years in the JCRC success. I dedicate this doctorate to both of them – they always knew I would make it. Thank you laboratory. for all. Prof Stephan Kaufmann at the Max Planck Institute for Infection Biology (MPIIB) in Berlin, for all that I have learnt from him in the area of tuberculosis biomarkers and related research.
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