Expression Pattern of Delta-Like 1 Homolog in Developing Sympathetic Neurons and Chromaffin Cells
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The Morphology, Androgenic Function, Hyperplasia, and Tumors of the Human Ovarian Hilus Cells * William H
THE MORPHOLOGY, ANDROGENIC FUNCTION, HYPERPLASIA, AND TUMORS OF THE HUMAN OVARIAN HILUS CELLS * WILLIAM H. STERNBERG, M.D. (From the Department of Pathology, School of Medicine, Tulane University of Louisiana and the Charity Hospital of Louisiana, New Orleans, La.) The hilus of the human ovary contains nests of cells morphologically identical with testicular Leydig cells, and which, in all probability, pro- duce androgens. Multiple sections through the ovarian hilus and meso- varium will reveal these small nests microscopically in at least 8o per cent of adult ovaries; probably in all adult ovaries if sufficient sections are made. Although they had been noted previously by a number of authors (Aichel,l Bucura,2 and von Winiwarter 3"4) who failed to recog- nize their significance, Berger,5-9 in 1922 and in subsequent years, pre- sented the first sound morphologic studies of the ovarian hilus cells. Nevertheless, there is comparatively little reference to these cells in the American medical literature, and they are not mentioned in stand- ard textbooks of histology, gynecologic pathology, nor in monographs on ovarian tumors (with the exception of Selye's recent "Atlas of Ovarian Tumors"10). The hilus cells are found in clusters along the length of the ovarian hilus and in the adjacent mesovarium. They are, almost without excep- tion, found in contiguity with the nonmyelinated nerves of the hilus, often in intimate relationship to the abundant vascular and lymphatic spaces in this area. Cytologically, a point for point correspondence with the testicular Leydig cells can be established in terms of nuclear and cyto- plasmic detail, lipids, lipochrome pigment, and crystalloids of Reinke. -
I. Introduction B. Adrenal Cortex
I. Introduction Adrenal Glands • suprarenal – they sit on top of the kidneys • each is composed of 2 distinct regions: A. Adrenal Medulla - the inner region - comprises 20% of the gland - secretes epinephrine and norepinephrine - derived from ectoderm B. Adrenal Cortex 1) Zona Glomerulosa (outermost region) - produces mineralocorticoids (aldosterone) • the outer region 2) Zona Fasiculata (middle region) - produces glucocorticoids (cortisol) as well as • comprises 80% of the gland estrogens and androgens • secretes corticosteroids 3) Zona Reticularis (innermost region) • derived from mesoderm - same function as zona fasiculata DHEA – dehydroepiandrosterone • an adrenal androgen in females • responsible for growth of pubic and axillary hair C. Pathologies Associated with Adrenal II. Mineralocorticoids (Aldosterone) Androgen Hypersecretion A. Functions 1.Adrenogenital Syndrome - promotes reabsorption of Na+ and - hypersecretion of androgens or estrogens secretion of K+ from the distal portion of the a) in the adult female: nephron..primary regulator of salt balance and extracellular volume - masculinization (i.e. hirsutism) -Similar (but less important) effect on salt b) in the female embryo: transport in colon, salivary glands, and - female pseudohermaphroditism sweat glands. c) in the adult male: - no effect d) in young boys: - precocious pseudopuberty 1 II. Mineralocorticoids (Aldosterone) C. Pathologies B. Regulation of Secretion 1. Hypersecretion 1. Renin Angiotensin a. primary hyperaldosteronism - Angiotensin II stimulates aldost. secretion - Conn’s syndrome 2. Potassium - usually due to a tumor on the gland + - high levels of K induce aldost. secretion - too much secretion of gland itself 3. ACTH –no direct role b. secondary hyperaldosteronism - default in renin angiotensin system - most common in atherosclerosis of renal arteries C. Pathologies III. Glucocorticoids (Cortisol) 1. -
HYPOTHALAMUS – PITUITARY-ADRENAL AXIS Learning Objectives OVERVIEW FUNCTIONAL ANATOMY
Introductory Human Physiology ©copyright Emma Jakoi HYPOTHALAMUS – PITUITARY-ADRENAL AXIS Emma R. Jakoi, Ph.D. Learning objectives • Describe the structural and functional organization of the adrenal gland. • Describe the synthesis and secretion of cortical adrenal hormones. • Describe the mechanism of action and physiologic effects of adrenal hormones. • Explain the control of adrenal hormone synthesis and secretion. Describe the major feedback loops that integrate the hypothalamic axis and body homeostasis. • Explain the physiologic roles of the adrenal hormones in normal physiology. OVERVIEW The adrenal glands maintain homeostasis in response to stress. Three major classes of hormones are secreted by these glands: aldosterone (mineralocorticoid), cortisol (glucocorticoid), DHEA (weak androgen), and catecholamines (epinephrine and norepinephrine). FUNCTIONAL ANATOMY The adrenal gland is located on top of the kidney. Like the pituitary, two distinct tissues merge during development to form the adrenal cortex (glandular tissue) and medulla (modified neuronal tissue) (Fig 1). 1 2 cortex 3 medulla Figure 1. Structure of the adrenal gland. The cortex secretes three steroid hormones: 1. aldosterone, 2. cortisol, 3. a weak androgen, DHEA. The medulla secretes epinephrine (Epi) and norepinephrine (NorEpi). 1 Introductory Human Physiology ©copyright Emma Jakoi MINERALOCORTICOIDS The major mineralocorticoid in humans is aldosterone. Aldosterone is NOT under the hypothalamus- pituitary control and does not mediate a negative feedback to this axis. Aldosterone secretion is increased by the vasoconstrictor, angiotensin II, and by elevated plasma K+ concentration. Elevated plasma Na+ inhibits the secretion of aldosterone. Aldosterone, acts in the kidney to promote secretion of K+ into the urine from the blood and the reabsorption of Na+ from the urine into the blood. -
Novel Autocrine Feedback Control of Catecholamine Release a Discrete Chromogranin a Fragment Is a Noncompetitive Nicotinic Cholinergic Antagonist Sushil K
Novel Autocrine Feedback Control of Catecholamine Release A Discrete Chromogranin A Fragment is a Noncompetitive Nicotinic Cholinergic Antagonist Sushil K. Mahata,* Daniel T. O’Connor,* Manjula Mahata,* Seung Hyun Yoo,‡ Laurent Taupenot,* Hongjiang Wu,* Bruce M. Gill,* and Robert J. Parmer* *Department of Medicine and Center for Molecular Genetics, University of California, San Diego, California 92093 and Department of Veterans Affairs Medical Center, San Diego, California 92161, and ‡National Institute of Deafness and Communicative Disorders, National Institutes of Health, Bethesda, Maryland 20892 Abstract completely established, recent evidence implicates chromogra- nin A as a precursor of several small biologically active secre- Catecholamine secretory vesicle core proteins (chromog- tion-inhibitory peptides that may play an autocrine regulatory ranins) contain an activity that inhibits catecholamine re- role in neuroendocrine secretion from a variety of cell types (3, lease, but the identity of the responsible peptide has been 7–10). The primary structure of chromogranin A reveals 8–10 elusive. Size-fractionated chromogranins antagonized nico- conserved pairs of basic amino acids that represent potential tinic cholinergic-stimulated catecholamine secretion; the in- proteolytic cleavage sites for the generation of such peptides hibitor was enriched in processed chromogranin fragments, (11–17), and chromogranin A is a substrate for the prohor- and was liberated from purified chromogranin A. Of 15 syn- mone convertases (18–20). of chromogranin A, one To date, several chromogranin A–derived peptides have %80 ف thetic peptides spanning (bovine chromogranin A344–364 [RSMRLSFRARGYGFRG- been identified that affect the secretory function of the parent PGLQL], or catestatin) was a potent, dose-dependent (IC50 cells. -
Radiotherapy of Malignant Pheochromocytoma—A Case Report
Case Report Page 1 of 7 Radiotherapy of malignant pheochromocytoma—a case report Chi-Yuan Yeh Department of Radiation Oncology, Tungs’ Taichung Metroharbor Hospital, Taichung, Taiwan Correspondence to: Department of Radiation Oncology, Tungs’ Taichung Metroharbor Hospital, No.699, Sec. 8, Taiwan Blvd., Taichung City 435, Taiwan. Email: [email protected]. Abstract: Pheochromocytomas (PCC) are rare tumors with an estimated incidence of 0.4 to 9.5 cases per 1 million per year. About 5–26% of PCC are malignant and presents with metastasis, for which there is currently no effective therapy. The treatment of choice is for PCC is radical surgery to reduce tumor burden, to provide symptomatic relief of catecholamine excess although complete eradication of the lesions is often not feasible. A number of case reports have been published on the role of radiotherapy for the treatment of PCC. Here we present a 53-year-old male stage III malignant PCC patient who received postoperative adjuvant radiotherapy. A review of current literature is also presented. Keywords: Radiotherapy; pheochromocytoma (PCC); malignant pheochromocytoma; hypertension Received: 12 December 2018; Accepted: 12 August 2019; Published: 27 August 2019. doi: 10.21037/tro.2019.08.02 View this article at: http://dx.doi.org/10.21037/tro.2019.08.02 Introduction reaction confirmed PCC. The term PCC was derived from the Greek words Pheochromocytomas (PCC) and paragangliomas (PGL) phaios (“dusky”), chroma (“color”), and cytoma (“tumor”). are rare catecholamine-secreting tumors that arise from The dark staining reaction of PCC tumor was caused by the chromaffin cells of the adrenal medulla and the sympathetic oxidation of intracellular catecholamines when stained with ganglia respectively. -
Some Fundamentals of Gonadal Development and Function Richmond W
Henry Ford Hospital Medical Journal Volume 8 | Number 3 Article 8 9-1960 Some Fundamentals Of Gonadal Development And Function Richmond W. Smith Jr. Raymond C. Mellinger Follow this and additional works at: https://scholarlycommons.henryford.com/hfhmedjournal Part of the Life Sciences Commons, Medical Specialties Commons, and the Public Health Commons Recommended Citation Smith, Richmond W. Jr. and Mellinger, Raymond C. (1960) "Some Fundamentals Of Gonadal Development And Function," Henry Ford Hospital Medical Bulletin : Vol. 8 : No. 3 , 324-344. Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol8/iss3/8 This Article is brought to you for free and open access by Henry Ford Health System Scholarly Commons. It has been accepted for inclusion in Henry Ford Hospital Medical Journal by an authorized editor of Henry Ford Health System Scholarly Commons. For more information, please contact [email protected]. SOME FUNDAMENTALS OF GONADAL DEVELOPMENT AND FUNCTION* RICHMOND W. SMITH, JR., M.D.** AND RAYMOND C. MELLINGER, M.D.** The traditional division of animal life into male and female forms is based on obvious biological differences, but these distinctions become less striking when we realize that life, in a sheer physico-chemical sense, is a spectrum of sexuality that maleness and femaleness are relative terms. Our conceptual devotion to a two compartment universe is apparent in many areas of life, sociologic, moral, legal, spiritual or biologic. Although reproductive obligations remain clear, albeit increasingly restricted, man's greater social sophistication is molding an order in which underlying biological distinctions of the two sexes are sometimes obscured by the potent solvents of culture, leisure and intellect. -
Dream Recall/Affect and the Hypothalamic–Pituitary–Adrenal Axis
Review Dream Recall/Affect and the Hypothalamic–Pituitary–Adrenal Axis Athanasios Tselebis 1, Emmanouil Zoumakis 2 and Ioannis Ilias 3,* 1 Department of Psychiatry, Sotiria Hospital, 115 27 Athens, Greece; [email protected] 2 First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Aghia Sophia Children’s Hospital, 115 27 Athens, Greece; [email protected] 3 Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, 115 21 Athens, Greece * Correspondence: [email protected]; Tel.: +30-213-205-1389 Abstract: In this concise review, we present an overview of research on dream recall/affect and of the hypothalamic–pituitary–adrenal (HPA) axis, discussing caveats regarding the action of hormones of the HPA axis (mainly cortisol and its free form, cortisol-binding globulin and glucocorticoid receptors). We present results of studies regarding dream recall/affect and the HPA axis under physiological (such as waking) or pathological conditions (such as in Cushing’s syndrome or stressful situations). Finally, we try to integrate the effect of the current COVID-19 situation with dream recall/affect vis-à-vis the HPA axis. Keywords: dreams; cortisol; stress; memory; sleep; HPA axis 1. Introduction—Dream Recall Almost all humans dream (indeed, there may be 0.5% of people who do not do so) [1]. Dreams are a series of images, thoughts and senses and are considered a specific type Citation: Tselebis, A.; Zoumakis, E.; of experience that occurs in our brain during sleep. During the dream, there is limited Ilias, I. Dream Recall/Affect and the control of the dream content, visual images and memory activation. -
Downloaded from Bioscientifica.Com at 09/30/2021 12:01:31AM Via Free Access 706 D BARON and Others · Foxl2 and Rainbow Trout Gonad Differentiation
705 An evolutionary and functional analysis of FoxL2 in rainbow trout gonad differentiation Daniel Baron1, Julie Cocquet2, Xuhua Xia3, Marc Fellous2, Yann Guiguen1 and Reiner A Veitia2 1INRA-SCRIBE, Campus de Beaulieu, 35042 Rennes Cedex, France 2INSERM E0021 & V361, Génomique fonctionnelle du Développement, Hôpital Cochin, 123 Bd de Port Royal, Paris, France 3Department of Biology and the Center for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, Canada (Requests for offprints should be addressed to R A Veitia; Email: [email protected]) Abstract FOXL2 is a forkhead transcription factor involved in ovarian development and function. Here, we have studied the evolution and pattern of expression of the FOXL2 gene and its paralogs in fish. We found well conserved FoxL2 sequences (FoxL2a) and divergent genes, whose forkhead domains belonged to the class L2 and were shown to be paralogs of the FoxL2a sequences (named FoxL2b). In the rainbow trout, FoxL2a and FoxL2b were specifically expressed in the ovary, but displayed different temporal patterns of expression. FoxL2a expression correlated with the level of aromatase, the key enzyme in estrogen production, and an estrogen treatment used to feminize genetically male individuals elicited the up-regulation of both paralogs. Conversely, androgens or an aromatase inhibitor down-regulated FoxL2a and FoxL2b in females. We speculate that there is a direct link between estrogens and FoxL2 expression in fish, at least during the period where the identity of the gonad is sensitive to hormonal treatments. Journal of Molecular Endocrinology (2004) 33, 705–715 Introduction been detected (Cocquet et al. 2002, Pannetier et al. -
Pig Gonads, Adrenal Glands and Brain C
Immunoreactive cytochrome P-45017\g=a\in rat and guinea- pig gonads, adrenal glands and brain C. Le Goascogne1, N. Sanan\l=e'\s1, M. Gou\l=e'\zou1, S. Takemori2, S. Kominami2, E. E. Baulieu1 and P. Robel1 1INSERM U33, Communications Hormonales, and Faculté de Médecine, Université Paris-sud, Lab Hormones F-94275 Bicêtre Cedex France 2 Faculty of Integrated Arts and Sciences, Hiroshima University, Hiroshima 730, Japan Summary. The cytochrome P-45017\g=a\-hydroxylase, 17\ar=r\20lyase (P-45017\g=a\) is the key enzyme responsible for the biosynthesis of androgens in steroidogenic organs. Its cellular localization has been examined with an immunohistochemical technique. In immature rat ovary, P-45017\g=a\was first detected in sparse interstitial cells on postnatal Day 8. The number of immunoreactive interstitial cells increased thereafter and the intensity of P-45017\g=a\staining in these cells was highest at 3 weeks of age. The intensity of staining then started to decline and was very faint at Day 35. From 6 weeks on, the distribution of immunoreactive P-45017\g=a\was of the adult type: it was detected exclusively in the thecal cells of the large antral, preovulatory, follicles. P-45017\g=a\was not detectable during pregnancy except on the day of parturition, when thecal cells were transiently immunoreactive. The staining had vanished 24 h after delivery. Human chorionic gonadotrophin (hCG), injected into immature females on Days 24 to 26, induced P-45017\g=a\prematurely in thecal cells. When injected on Days 12 to 14 of pregnancy, hCG also induced P-45017\g=a\in the thecal cells surrounding the largest follicles, whereas the interstitial and luteal cells were not immunostained. -
Extra-Adrenal Chromaffin Cells of the Zuckerkandl´S Paraganglion: Morphological and Electrophysiological Study
275 Extra-adrenal chromaffin cells of the Zuckerkandl´s paraganglion: morphological and electrophysiological study. Beatriz Galán-Rodríguez, M. Pilar Ramírez-Ponce, Fadwa El Banoua, Juan A. Flores, Juan Bellido and Emilio Fernández-Espejo. Departamento de Fisiología Médica y Biofísica. Universidad de Sevilla. Spain. Correspondence: Dra. Beatriz Galán Rodríguez or Dr. Emilio Fernández-Espejo, Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, 41009. Sevilla. Spain. Phone: 34-954-556584; Fax: 34-954-551769; Email: [email protected] ; [email protected] Cell Biology of the Chromaffin Cell R. Borges & L. Gandía Eds. Instituto Teófilo Hernando, Spain, 2004 Cell Biology of the Chromaffin Cell 276 Parkinson´s disease is one of the most important neurodegenerative disorders that affects to one out of a hundred of the world population elder than 65. It has been observed in our laboratory, for the first time, that intrabrain transplantation of chromaffin cell aggregates from the Zuckerkandl´s organ, an extraadrenal paraganglion located adjacent to the lower abdominal aorta, induced gradual improvement of functional deficits in animal models of Parkinson´s disease1. This functional regeneration was likely caused by long-survival of grafted cells and chronic trophic action of dopaminotrophic factors, glial cell line-derived 2,3 4,5 factor (GDNF) and transforming growth factor beta1 (TGF-b1) , which are expressed and delivered by long-surviving grafted chromaffin cells. The objective of this study is to discern the morphological and cytological characteristics of extra-adrenal cells of the Zuckerkandl’s organ. On the other hand, long survival of extra-adrenal chromaffin cells could be related to resistance to hypoxia, since it is certainly know that hypoxia is a primary factor involved in cell death after intrabrain grafting. -
Adrenal Gland Hormones
CHAPTER 8 Adrenal Gland Hormones Devra K. Dang, PharmD, BCPS, CDE, FNAP | Trinh Pham, PharmD, BCOP | Jennifer J. Lee, PharmD, BCPS, CDE LEARNING OBJECTIVES KEY TERMS AND DEFINITIONS After completing this chapter, you should be able to ACTH (adrenocorticotropic hormone) — a hormone produced 1. Identify the hormones produced by the adrenal glands by the pituitary gland that stimulates 2. Describe the functions of mineralocorticoids and glucocorticoids in the body the adrenal cortex to produce glucocorticoids, mineralocorticoids, 3. Recognize the signs and symptoms of adrenal insuffi ciency and androgens. PART 4. Describe the pharmacological treatment of patients with acute and chronic adrenal Addison ’ s disease — a disorder insuffi ciency in which the adrenal glands do not produce enough steroid hormones. 3 5. Recognize the signs and symptoms of Cushing ’ s syndrome and the result of too Adenoma — a benign much cortisol (noncancerous) tumor of glandular 6. Describe the pharmacologic and nonpharmacologic management of patients with origin. Cushing ’ s syndrome Adrenal insuffi ciency — a term 7. List management strategies for administration of glucocorticoid and mineralocorti- referring to a defi ciency in the levels of adrenal hormones. coid therapy to avoid development of adrenal disorders Aldosterone — the hormone produced by the adrenal glands that regulates the balance of sodium, he adrenal glands are an integral part of the endocrine system, secreting water, and potassium concentrations in the body. T hormones that act throughout the body to regulate functions and promote Corticotropin-releasing homeostasis. In addition to the neurotransmitters epinephrine and norepineph- hormone (CRH) — a hormone rine, the corticosteroids secreted by the adrenal glands are vital to a wide released by the hypothalamus that variety of physiological processes. -
Role of Thyroid Hormones in the Development of Gonadal Sex, External Morphology and Intestinal System of Zebrafish (Danio Rerio)
ROLE OF THYROID HORMONES IN THE DEVELOPMENT OF GONADAL SEX, EXTERNAL MORPHOLOGY AND INTESTINAL SYSTEM OF ZEBRAFISH (DANIO RERIO) by PRAKASH SHARMA, B.S., M.S. A Dissertation In BIOLOGY Submitted to the Graduate Faculty of Texas Tech University in Partial Fulfillment of the Requirements for the Degree of DOCTOR OF PHILOSOPHY Approved Dr. Reynaldo Patiño Chair of Committee Dr. Gregory D. Mayer Dr. James Carr Dr. Lauren Gollahon Dr. Nathan Collie Dr. Richard Strauss Dominick Joseph Casadonte Dean of the Graduate School December, 2012 Copyright 2012, Prakash Sharma Texas Tech University, Prakash Sharma, December 2012 ACKNOWLEDGMENTS First, I am privileged to thank Dr. Reynaldo Patiño, my major advisor and mentor for his guidance and encouragement which have been of immense support. He has been there to help and extend his guidance, anywhere, anytime, even at wee hours despite his busy schedule. Through him, I have not only picked up skills and a sense of responsibility, but also a whole new level of dedication. It is definitely a lifetime opportunity to have worked with an efficient and resourceful scientist like him. I am honored to thank my Committee Members for their enthusiasm to scrutinize my research. Thanks to Drs. Gregory D. Mayer, James Carr, Lauren Gollahon, Nathan Collie, and Richard Strauss. Their suggestions, ideas and information on the analysis of my study were of great significance. I could not have asked for a better cooperating team. Also, a million thanks to Dr. Gregory D. Mayer for supporting and guiding me immensely throughout my research program and for allowing me the opportunity to work in his lab.