January 2016 Newsletter Support EFF
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Boada SEA Eagenda 2020
TheBestof South East Asia 2020 Bangladesh, Brunei, Cambodia, Indonesia, Laos, Malaysia, Maldives, Myanmar, Philippines, Singapore, Sri Lanka, Vietnam FACULTY The American Diabetes Association (ADA) and Novo Nordisk are pleased to invite you to a series of official webinars highlighting the most important education from the American Diabetes Association Scientific Sessions. Mark your calendars now. Athena Philis-Tsimikas, MD Simon Heller, MD Jay H. Shubrook DO FACOFP, FAAFP Derek LeRoith, MD, PhD, FACP Corporate Vice President of the Scripps Whittier Professor of Clinical Diabetes Professor. Primary Care Department Director of Research Diabetes Institute at Scripps Health. Director of University of Sheffield Director of Clinical Research and Diabetes Services Division of Endocrinology, Diabetes Monday, June 22 Community Engagement at Scripps Translational Sheffield, England Touro University California College of Osteopathic and Bone Diseases Icahn School Science Institute. San Diego, California, USA Medicine, Vallejo, California, USA of Medicine, Mount Sinai, New York, USA Webinar 1: 6:00PM-7:30PM Malaysia Time Monday, June 29 Webinar 2: 6:00PM-7:30PM Malaysia Time Monday, July 6 Webinar 3: 6:00PM-7:30PM Malaysia Time Monday, July 13 Webinar 4: 6:00PM-7:30PM Malaysia Time Kenneth Cusi, M.D., Andrew JM Boulton, MD, DSc (Hon), Michelle Magee, MD, MBBCh, Richard E. Pratley, MD F.A.C.P., F.A.C.E. FACP, FICP, FRCP BAO, LRCPSI AdventHealth. Samuel E. Crockett Chair in Diabetes Research. Professor of Medicine President, International Diabetes -
Mount Sinai Health System Appoints New Chief for Division of Endocrinology, Diabetes and Bone Disease
Mount Sinai Health System Appoints New Chief for Division of Endocrinology, Diabetes and Bone Disease mountsinai.org /about-us/newsroom/press-releases/mount-sinai-health-system-appoints-new-chief-for-division- of-endocrinology-diabetes-and-bone-disease New York, NY – May 31, 2017 /Press Release/ –– Andrea Dunaif, MD, an internationally renowned diabetes and women’s health expert, has been appointed the new Chief for the Hilda and J. Lester Gabrilove Division of Endocrinology, Diabetes, and Bone Disease for the Mount Sinai Health System. Dr. Dunaif replaced Derek Leroith, MD, PhD, who has served as interim chief for the last year. In her new role, Dr. Dunaif will build on Mount Sinai’s considerable strengths in research on diabetes, metabolism, and endocrine disorders. Dr. Dunaif also plans to expand Mount Sinai’s comprehensive clinical services for patients with diabetes and other endocrine disorders, including its artificial pancreas program. Dr. Dunaif is an exceptional physician and researcher in the field of diabetes and women’s health,” said Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System. “We look forward to her help in building on our long and distinguished tradition of excellence in research and education in the field of endocrinology, diabetes and bone disease.” Dr. Dunaif comes to Mount Sinai from Northwestern University’s Feinberg School of Medicine, in Chicago, where she is the Charles F. Kettering Professor of Endocrinology and Metabolism and was the Chief of the Division of Endocrinology, Metabolism, and Molecular Medicine for 10 years. -
Highly Specific Role of the Insulin Receptor in Breast Cancer Progression
R Rostoker et al. Insulin receptor in breast cancer 22:2 145–157 Research progression Highly specific role of the insulin receptor in breast cancer progression Ran Rostoker1, Sagi Abelson2, Keren Bitton-Worms1, Inna Genkin1, Sarit Ben-Shmuel1, Maria Dakwar1, Zila Shen Orr1, Avishay Caspi1, Maty Tzukerman2 and Derek LeRoith1,3 1Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel Correspondence 2The Laboratory of Molecular Medicine, Rambam Health Care Campus and Rappaport Faculty of Medicine and should be addressed Research Institute, Technion, Haifa 31096, Israel to D LeRoith 3Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York City, Email New York, USA [email protected] Abstract Accumulating evidence from clinical trials indicates that specific targeting of the IGF1 receptor Key Words (IGF1R) is not efficient as an anti-breast cancer treatment. One possible reason is that the " hyperinsulinemia mitogenic signals from the insulin receptor (IR) can be processed independently or as " insulin receptor compensation to inhibition of the IGF1R. In this study, we highlight the role of the IR in " insulin-like growth factor 1 mediating breast tumor progression in both WT mice and a hyperinsulinemic MKR mouse receptor model by induction of Ir (Insr)orIgf1r knockdown (KD) in the mammary carcinoma Mvt-1 cell " breast cancer and CD24 line. By using the specific IR antagonist-S961, we demonstrated that Igf1r-KD induces elevated responses by the IR to IGF1. On the other hand, Ir-KD cells generated significantly smaller tumors in the mammary fat pads of both WT and MKR mice, as opposed to control cells, whereas Endocrine-Related Cancer the Igf1r-KD cells did not. -
Pediatric PROGRESS
BECOMING A BETTER BOSS AT THE BENCH JULY 2019 THE LEADING MAGAZINE FOR ENDOCRINOLOGISTS INTERNATIONAL Pediatric PROGRESS The Vital Role of Endocrine Science in Advancing Children’s Health SNACK ATTACKS: Screen time’s relationship with unhealthy snacking in adolescents. GROWING PAINS & GAINS: An ENDO 2019 study shows a link between obesity and precocious puberty in boys. NEWBORN CONUNDRUM: Addressing the challenges treating infants with differences in sex development. A DELICATE BALANCE: New Society guideline on treating older patients with diabetes PAYING TRIBUTE: Remembering Lewis Braverman & Elizabeth Barrett-Connor THE LEADING MAGAZINE FOR ENDOCRINOLOGISTS 2017 – 2019 EDITORIAL ADVISORY BOARD Henry Anhalt, DO Bergen County Pediatric Endocrinology Chair, Hormone Health Network VP, Medical Affairs, Science 37 Sally Camper, PhD Department of Human Genetics University of Michigan Medical School Rodolfo J. Galindo, MD Assistant Professor of Medicine Mount Sinai School of Medicine Christian M. Girgis, MBBS, PhD, FRACP Royal North Shore and Westmead Hospitals University of Sydney, Australia Andrea Gore, PhD Division of Pharmacology and Toxicology University of Texas Daniel A. Gorelick, PhD Baylor University, Houston, Texas M. Carol Greenlee, MD, FACP Western Slope Endocrinology Grand Junction, Colo. (Faculty for Transforming Clinical Practice initiative [TCPi]) GET THE CASE Gary D. Hammer, MD, PhD STUDIES YOU NEED Millie Schembechler Professor of Adrenal Cancer, Endocrine Oncology Program OF ALL ASPECTS OF University of Michigan Robert W. Lash, MD ENDOCRINOLOGY! Chief Professional & Clinical Officer, Endocrine Society Improve patient care with cases from the Karl Nadolsky, DO popular live Meet-the-Professor sessions Diabetes Obesity & Metabolic Institute Walter Reed National Military Medical Center presented during ENDO 2019. -
Highly Specific Role of the Insulin Receptor in Breast Cancer Progression
R Rostoker et al. Insulin receptor in breast cancer 22:2 145–157 Research progression Highly specific role of the insulin receptor in breast cancer progression Ran Rostoker1, Sagi Abelson2, Keren Bitton-Worms1, Inna Genkin1, Sarit Ben-Shmuel1, Maria Dakwar1, Zila Shen Orr1, Avishay Caspi1, Maty Tzukerman2 and Derek LeRoith1,3 1Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel Correspondence 2The Laboratory of Molecular Medicine, Rambam Health Care Campus and Rappaport Faculty of Medicine and should be addressed Research Institute, Technion, Haifa 31096, Israel to D LeRoith 3Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York City, Email New York, USA [email protected] Abstract Accumulating evidence from clinical trials indicates that specific targeting of the IGF1 receptor Key Words (IGF1R) is not efficient as an anti-breast cancer treatment. One possible reason is that the " hyperinsulinemia mitogenic signals from the insulin receptor (IR) can be processed independently or as " insulin receptor compensation to inhibition of the IGF1R. In this study, we highlight the role of the IR in " insulin-like growth factor 1 mediating breast tumor progression in both WT mice and a hyperinsulinemic MKR mouse receptor model by induction of Ir (Insr)orIgf1r knockdown (KD) in the mammary carcinoma Mvt-1 cell " breast cancer and CD24 line. By using the specific IR antagonist-S961, we demonstrated that Igf1r-KD induces elevated responses by the IR to IGF1. On the other hand, Ir-KD cells generated significantly smaller tumors in the mammary fat pads of both WT and MKR mice, as opposed to control cells, whereas Endocrine-Related Cancer the Igf1r-KD cells did not. -
Of Mount Sinai School of Medicine
the hilda & J. lester Gabrilove division of endoCrinoloGy, diabetes, and bone disease of Mount Sinai School of Medicine researCh eduCation Patient Care Community innovation AND the Future vision statement Gaining national and international recognition as the leading endocrine division in the treatment, prevention, and care of diabetes, endocrine, and metabolic disorders . mission statement to provide the highest quality care to our patients, and to improve the outcomes of patients with diabetes, endocrine, and metabolic disorders. to be at the forefront and cutting edge of research on endocrine diseases and diabetes and to excel in providing the best educational programs to trainees and patients. to develop innovative quality improvement programs to achieve the highest quality standards in patient care. Yaron Tomer, MD, FACP Chief, hilda & J. lester Gabrilove division of endocrinology, diabetes, and bone disease dear friends and colleagues, it gives me great pleasure and pride to present an overview of the hilda & J. lester Gabrilove division of endocrinology, diabetes, and bone disease, one of the top ranked divisions in the nation. it was at mount sinai training as a fellow, at the bedside and at the bench-side, that i was first introduced to, and enchanted by, the wonders of endocrinology. i began my lifelong work on the mechanisms leading to the development of autoimmune thyroiditis and type 1 diabetes under the astounding mentorship of former division Chief terry F. davies, md, FrCP. under his leadership, the division established outstanding research, clinical, and training programs. i am humbled by the fact that i will be leading the division that is the home of my remarkable mentors and teachers. -
Derek Leroith MD Phd Director of the Metabolism
1 CURRICULUM VITAE Derek LeRoith, M.D., Ph.D., F.A.C.P. ADDRESS: Derek LeRoith MD PhD Director of the Metabolism Institute Chief of the Division of Endocrinology, Diabetes and Bone Diseases Director of the Metabolism Institute Mt.Sinai School of Medicine 1 Gustave Levy Place-Box 1055 Atran B4-36 New York NY 10029-6574 Tel 212 241 6306 Fax 212 241 4159 [email protected] Date of Birth: January 3, 1945 Education: Sea Point Boy's High School, Cape Matriculation in 1961, with distinction in mathematics Degrees: 1967 M.B. Ch.B (M.D. equivalent) University of Cape Town 1973 Ph.D. Thesis University of Cape Town 1974 F.C.P. (S.A.) Fellow, College of Physicians of S. Africa 1975 M.R.C.P. (U.K.) Member of the Royal College of Physicians of the United Kingdom Postgraduate Training and Career: 2 1968 House Physician Professorial, Medical and Surgical Units, Groote Schuur Hospital, University of Cape Town 1969 Resident Department of Pediatrics, Kaplan Hospital, Rehovot, Israel (6 months) Family Doctor Kibbutzim - Galil Elyon (6 months) 1970-72 Research Fellow Ph.D. Student in Research Laboratory of Professor B.L. Pimstone, Department of Medicine, University of Cape Town 1972-74 Resident and Tutor Department of Medicine, Groote Schuur Hospital, University of Cape Town (9 months Endocrine Fellow) 1975 Senior Resident The Middlesex (teaching) Hospital, London, Departments of Medicine and Geriatrics 1976 Attending (6 months) Renal Unit and Endocrine Clinics, Meir Hospital, Kfar Saba, Israel 1976 Attending in Medicine and Endocrinology Department of Medicine, Soroka Medical Center, Beersheva, Israel. -
Mountsinaiar2015.Pdf
ONE DEPARTMENT, ONE MISSION Department of Medicine TABLE OF CONTENTS From the Chair 1 Our Missions 2 Our Divisions 7 Leadership Appointments 46 Outstanding Achievements 50 Advisory Board 52 onevision novel, flexible, proactive department To say that the past year was complex is an understatement. Recently, the Icahn School of Medicine at Mount Sinai merged with the Beth Israel Medical Center, Beth Israel Brooklyn, St. Luke’s and Roosevelt Hospitals, and New York Eye and Ear Infirmary to become one academic medical center. Today, this newly unified Department of Medicine is an integral and vital part of the expanded Mount Sinai Health System. The Department of Medicine is now one of the largest, multidimensional academic training grounds in the country, encompassing 12 divisions across seven campuses. We have more than 2,000 physicians, 400 residents, 300 fellows and 1,000 employees in our department and a budget of nearly $350 million. But don’t be intimidated by our enormous size or big numbers; rather, be inspired by the possibilities that such a dynamic and evolving department can create. Although it has been challenging, this merger has given us an opportunity to create one novel, flexible, and proactive department dedicated to excellence in all disciplines. We are in a unique position of being able to fulfill our tripartite mission of providing excellent care; driving change in health care delivery through scientific innovation; and training tomorrow’s physicians to provide that care. And we should now reexamine all of our assumptions about how patient care is provided; how we train future physicians; and how we turn the phrase “bench-to-bedside” into a reality rather than just a clever marketing expression. -
Bestof South East Asia 2020
TheBestof South East Asia 2020 Bangladesh, Brunei, Cambodia, Indonesia, Laos, Malaysia, Maldives, Myanmar, Philippines, Singapore, Sri Lanka, Vietnam FACULTY The American Diabetes Association (ADA) and Novo Nordisk are pleased to invite you to a series of official webinars highlighting the most important education from the American Diabetes Association Scientific Sessions. Mark your calendars now. Athena Philis-Tsimikas, MD Simon Heller, MD Jay H. Shubrook DO FACOFP, FAAFP Derek LeRoith, MD, PhD, FACP Monday, June 29 Corporate Vice President of the Scripps Whittier Professor of Clinical Diabetes Professor. Primary Care Department Director of Research Webinar 2: 6:00PM-7:30PM Malaysia Time Diabetes Institute at Scripps Health. Director of University of Sheffield Director of Clinical Research and Diabetes Services Division of Endocrinology, Diabetes Community Engagement at Scripps Translational Sheffield, England Touro University California College of Osteopathic and Bone Diseases Icahn School Science Institute. San Diego, California, USA Medicine, Vallejo, California, USA of Medicine, Mount Sinai, New York, USA Monday, July 6 Webinar 3: 6:00PM-7:30PM Malaysia Time Monday, July 13 Webinar 4: 6:00PM-7:30PM Malaysia Time Monday, July 20 Webinar 1: 6:00PM-7:30PM Malaysia Time Kenneth Cusi, M.D., Andrew JM Boulton, MD, DSc (Hon), Michelle Magee, MD, MBBCh, Richard E. Pratley, MD F.A.C.P., F.A.C.E. FACP, FICP, FRCP BAO, LRCPSI AdventHealth. Samuel E. Crockett Chair in Diabetes Research. Professor of Medicine President, International Diabetes -
ADA Standards of Medical Care in Diabetes 2018
THE JOURNAL OF CLINICAL AND APPLIED RESEARCH AND EDUCATION VOLUME 41 | SUPPLEMENT 1 WWW.DIABETES.ORG/DIABETESCARE JANUARY 2018 PLE M E P N U T S 1 AMERICAN DIABETES ASSOCIATION STANDARDS OF MEDICAL CARE IN DIABETES—2018 ISSN 0149-5992 January 2018 Volume 41, Supplement 1 [T]he simple word Care may suffice to express [the journal’s] philosophical mission. The new journal is designed to promote better patient care by serving the expanded needs of all health professionals committed to the care of patients with diabetes. As such, the American Diabetes Association views Diabetes Care as a reaffirmation of Francis Weld Peabody’s contention that “the secret of the care of the patient is in caring for the patient.” —Norbert Freinkel, Diabetes Care, January-February 1978 EDITOR IN CHIEF Matthew C. Riddle, MD ASSOCIATE EDITORS EDITORIAL BOARD George Bakris, MD Nicola Abate, MD Maureen Monaghan, PhD, CDE Lawrence Blonde, MD, FACP Vanita R. Aroda, MD Kristen J. Nadeau, MD, MS Andrew J.M. Boulton, MD Geremia Bolli, MD Kwame Osei, MD David D’Alessio, MD John B. Buse, MD, PhD Kevin A. Peterson, MD, MPH, FRCS(Ed), Mary de Groot, PhD Robert J. Chilton, DO, FACC, FAHA FAAFP Eddie L. Greene, MD Kenneth Cusi, MD, FACP, FACE Jonathan Q. Purnell, MD Frank B. Hu, MD, MPH, PhD Paresh Dandona, MD, PhD Peter Reaven, MD Steven E. Kahn, MB, ChB J. Hans DeVries, MD, PhD Ravi Retnakaran, MD, MSc, FRCPC Sanjay Kaul, MD, FACC, FAHA Ele Ferrannini, MD Helena Wachslicht Rodbard, MD Derek LeRoith, MD, PhD Franco Folli, MD, PhD Elizabeth Seaquist, MD Robert G. -
Is Male Hormonal Contraception Finally Within Reach?
NIH’S FRANCIS S. COLLINS OPENS ENDO 2019 JUNE 2019 THE LEADING MAGAZINE FOR ENDOCRINOLOGISTS INTERNATIONAL One Step CLOSER: Is Male Hormonal Contraception Finally Within Reach? New research presented at ENDO 2019 in New Orleans has reignited anticipation of a potential novel male hormonal contraceptive. After recent scientific breakthroughs, how long before men are “on the pill” or another means of hormonal contraceptive? THE LONG HAUL: Testosterone treatment & men with obesity. TAKING LEAVE: Handling medical or parental leave and your practice. THE LEADING MAGAZINE FOR ENDOCRINOLOGISTS 2017 – 2019 EDITORIAL ADVISORY BOARD Henry Anhalt, DO Bergen County Pediatric Endocrinology Chair, Hormone Health Network VP, Medical Affairs, Science 37 Sally Camper, PhD Department of Human Genetics University of Michigan Medical School Rodolfo J. Galindo, MD Assistant Professor of Medicine Mount Sinai School of Medicine Christian M. Girgis, MBBS, PhD, FRACP Royal North Shore and Westmead Hospitals University of Sydney, Australia Andrea Gore, PhD Division of Pharmacology and Toxicology University of Texas CLINICAL ENDOCRINOLOGY UPDATE Daniel A. Gorelick, PhD IS BACK IN TWO LOCATIONS FOR 2019: Baylor University, Houston, Texas MIAMI, FLORIDA AND SEATTLE, WASHINGTON! M. Carol Greenlee, MD, FACP Western Slope Endocrinology Grand Junction, Colo. REGISTER NOW (Faculty for Transforming Clinical Practice initiative [TCPi]) Gary D. Hammer, MD, PhD Millie Schembechler Professor of Adrenal Cancer, Endocrine Oncology Program University of Michigan Robert W. Lash, MD Chief Professional & Clinical Officer, Endocrine Society Karl Nadolsky, DO Diabetes Obesity & Metabolic Institute Walter Reed National Military Medical Center; Uniformed Services University Joshua D. Safer, MD, FACP Center for Transgender Medicine and Surgery, Endocrinology Fellowship Training Boston Medical Center; Boston University School of Medicine Shehzad Topiwala, MD, FACE EARLY REGISTRATION DEADLINE: Endocrinology Department SevenHills Hospital, Mumbai, India AUGUST 1, 2019 Kristen R. -
The News of the Year the Work of Decades
1 Medical Education dean’s report the news of the year the work of decades An insight into the vision and methodology of some of the world’s most widely respected scientists and physicians table of contents 02 Dean’s Message 10 President’s Message 12 Chairman’s Message 14 Virology 20 Stem Cell Biology 26 Community Health 32 Head and Neck Surgery 38 Cardiovascular 52 Adolescent Health 58 Medical Education 64 Graduate Education 70 Financial Overview 74 Mount Sinai Affiliates 75 Select Centers, Programs, and Projects 76 Select Faculty Honors and Awards 86 Leadership 88 Boards of Trustees This report, The News of the Year – The Work of Decades, offers an insight into the vision and methodology of some of the world’s most widely respected scientists and physicians and the global impact of their achievements. National Institutes of Health, which named Mount Sinai a Center of Excellence for Influenza Research and Surveillance. World-famous stem cell biologist Dr. Ihor Lemischka has moved Mount Sinai into the forefront of stem cell research. Under his direction, the Black Family Stem Cell Institute dennis s. charney, md is poised to be a major recipient of New York State’s recently announced $100 million dean of mount sinai school of medicine, executive vice president for academic affairs of the mount sinai medical center, and the anne and joel ehrenkranz professor in the departments of commitment in 2008 to stem cell research. psychiatry, neuroscience, pharmacology, and systems therapeutics When environmental health pioneer Dr. Philip Landrigan stood up for the heroes of 9/11 with the definitive study of their ongoing health problems, the public, Senator Hillary Clinton, and her congressional colleagues took note.