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Boada SEA Eagenda 2020
TheBestof South East Asia 2020 Bangladesh, Brunei, Cambodia, Indonesia, Laos, Malaysia, Maldives, Myanmar, Philippines, Singapore, Sri Lanka, Vietnam FACULTY The American Diabetes Association (ADA) and Novo Nordisk are pleased to invite you to a series of official webinars highlighting the most important education from the American Diabetes Association Scientific Sessions. Mark your calendars now. Athena Philis-Tsimikas, MD Simon Heller, MD Jay H. Shubrook DO FACOFP, FAAFP Derek LeRoith, MD, PhD, FACP Corporate Vice President of the Scripps Whittier Professor of Clinical Diabetes Professor. Primary Care Department Director of Research Diabetes Institute at Scripps Health. Director of University of Sheffield Director of Clinical Research and Diabetes Services Division of Endocrinology, Diabetes Monday, June 22 Community Engagement at Scripps Translational Sheffield, England Touro University California College of Osteopathic and Bone Diseases Icahn School Science Institute. San Diego, California, USA Medicine, Vallejo, California, USA of Medicine, Mount Sinai, New York, USA Webinar 1: 6:00PM-7:30PM Malaysia Time Monday, June 29 Webinar 2: 6:00PM-7:30PM Malaysia Time Monday, July 6 Webinar 3: 6:00PM-7:30PM Malaysia Time Monday, July 13 Webinar 4: 6:00PM-7:30PM Malaysia Time Kenneth Cusi, M.D., Andrew JM Boulton, MD, DSc (Hon), Michelle Magee, MD, MBBCh, Richard E. Pratley, MD F.A.C.P., F.A.C.E. FACP, FICP, FRCP BAO, LRCPSI AdventHealth. Samuel E. Crockett Chair in Diabetes Research. Professor of Medicine President, International Diabetes -
“If We Could Change Ourselves, the Tendencies
10/10/17 GENDERED INEQUALITY: DECONSTRUCTING BARRIERS TO ENABLE SENSITIVE SYSTEMIC “IF WE COULD CHANGE OURSELVES, PRACTICE WITH DIVERSE PEOPLE AND THE TENDENCIES IN THE WORLD RELATIONSHIPS WOULD ALSO CHANGE.” ANNE PROUTY - MAHATMA GANDHI OCTOBER 2017 AUSTRALIAN ASSOCIATION FOR FAMILY THERAPY ANNUAL CONFERENCE ADELAIDE, AUSTRALIA GLOBAL “GENDER” (Binary) Gender Inequities DEADLY CUTTING EDGE * MISERABLE TO PROMOTE SOCIAL JUSTICE * REAL ADVOCATE FOR CLIENTS SEX AND GENDER 2007 “YogyAkArtA Principles”: 28 Principles oF the THE WORLD HEALTH ORGANISATION HAS RECOGNISED ApplicAtion oF International HumAn Rights LAw in SEX AND GENDER GLOBALLY AS CORE SOCIAL RelAtion to SexuaL Orientation DETERMINANTS OF PHYSICAL AND MENTAL HEALTH and Gender Identity 64 AND WELL-BEING 44 • LGBTI are 11% of Australians as of 20146 • www.YogyAkArtAprinciples.org • GENDER Keynote/YogyAkArtA principles_en.pdF • 1.7% oF AustrAliAns Are estimated to be Intersex (AustraliAn HumAn Rights Commission) • 2% oF people globAlly estimAted to be non-binAry gender • 34% oF LGBTI AustrAliAns hide their identity when accessing services 1 10/10/17 ApproAches to IDENTITY SociAl Justice MultiPLe CulturaL Communities • WHO DEFINES WHOM? Human Diversity within Communities/Contexts • EACH PERSON’S EXPERIENCE? Human Diversity Across LifesPans • BY INTERACTING WITH EACH OTHER? • INTERACTING BY PROXY AND VIA COMMUNITIES? INTERSECTIONALITY INTERSECTIONALITY - IDENTITIES INTERSECTIONALITY - IDENTITIES SEX &/OR GENDER ID ETHNIC ID SEX &/OR GENDER ID ETHNIC ID SEXUAL ORIENTATION SPIRITUAL -
Testicular Prosthesis in Paediatric Urology: Current Concepts and Available Alternatives
Review Article Testicular Prosthesis in Paediatric Urology: Current Concepts and Available Alternatives Nitin Sharma, M. Bajpai and Shasanka Shekhar Panda Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi-110029, India Abstract: Prosthesis is an artificial material used as a replacement for its natural counterpart. Use of testicular prosthesis in pediatric urology is limited and indications are well defined. In this review we tried to find out and summarize the current indications and available options in pediatric urology for these prosthesis. Keywords: Testicular prosthesis, Orchidometer, Anorchia Prosthesis is an artificial material used as a replacement for c). Torsion its natural counterpart. Use of testicular prosthesis in pediatric d). Dysplasia urology is limited and indications are well defined. In this e). Dysgenesis review we tried to find out and summarize the current f). Intersex disorders requiring male genitoplasty indications and available options in pediatric urology for these B). Assessment of the size of prosthesis required: prosthesis. An extensive PubMed, Medline and Google scholar search was done to see the available literature and This entirely depends upon the age at placement of the current practice. For the purpose of simplicity the subsequent prosthesis and the scrotal development. The assessment of discussion is under following heads: the volume of testis is done using an instrument called as Orchidometer/ Orchiometer. The orchidometer was introduced Indications for the first time by Swiss pediatric endocrinologist Prof. Assessment of size required Andrea Prader1 of university of Zurich in 1966. It consists of Timing a string of twelve numbered wooden or plastic beads (some Procedure time referred as Prader's balls, medical worry beads or Complications endocrine rosary) of increasing size from one to twenty-five Evolution and currently available options milliliters (Fig 1). -
Mount Sinai Health System Appoints New Chief for Division of Endocrinology, Diabetes and Bone Disease
Mount Sinai Health System Appoints New Chief for Division of Endocrinology, Diabetes and Bone Disease mountsinai.org /about-us/newsroom/press-releases/mount-sinai-health-system-appoints-new-chief-for-division- of-endocrinology-diabetes-and-bone-disease New York, NY – May 31, 2017 /Press Release/ –– Andrea Dunaif, MD, an internationally renowned diabetes and women’s health expert, has been appointed the new Chief for the Hilda and J. Lester Gabrilove Division of Endocrinology, Diabetes, and Bone Disease for the Mount Sinai Health System. Dr. Dunaif replaced Derek Leroith, MD, PhD, who has served as interim chief for the last year. In her new role, Dr. Dunaif will build on Mount Sinai’s considerable strengths in research on diabetes, metabolism, and endocrine disorders. Dr. Dunaif also plans to expand Mount Sinai’s comprehensive clinical services for patients with diabetes and other endocrine disorders, including its artificial pancreas program. Dr. Dunaif is an exceptional physician and researcher in the field of diabetes and women’s health,” said Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System. “We look forward to her help in building on our long and distinguished tradition of excellence in research and education in the field of endocrinology, diabetes and bone disease.” Dr. Dunaif comes to Mount Sinai from Northwestern University’s Feinberg School of Medicine, in Chicago, where she is the Charles F. Kettering Professor of Endocrinology and Metabolism and was the Chief of the Division of Endocrinology, Metabolism, and Molecular Medicine for 10 years. -
Testicular Volume Measurement: Comparison of Prader Orchidometer, Ultrasound Scan and Water Displacement a Dissertation Submitted By
TESTICULAR VOLUME MEASUREMENT: COMPARISON OF PRADER ORCHIDOMETER, ULTRASOUND SCAN AND WATER DISPLACEMENT A DISSERTATION SUBMITTED BY DR MBAERI, TIMOTHY UZOMA MBBS (Port Harcourt) DEPARTMENT OF SURGERY NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL, NNEWI TO THE NATIONAL POSTGRADUATE MEDICAL COLLEGE OF NIGERIA IN PART FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF THE FINAL FELLOWSHIP OF THE MEDICAL COLLEGE IN SURGERY (FMCS) JUNE 2011 1 DECLARATION I hereby declare that the research project leading to this dissertation was actually carried out by me under the guidance of my supervisors. The work has neither been presented in part nor in full to any other College for a Fellowship; also it has not been submitted elsewhere for publication. ..................................................... DR MBAERI TIMOTHY UZOMA 2 DEDICATION I DEDICATE THIS WORK TO MY DEAR WIFE AMAKA WHO BORE THE BURDEN OF MY NEGLECT IN THE COURSE OF MY PROGRAMME, HER PATIENCE, PRAYERS AND ENCOURAGEMENT. TO MY PARENTS MR. AND MRS. REUBEN IBEBUKA MBAERI WHO INSPITE OF ALL ODDS MADE ME QUALIFY AS A DOCTOR IN THE FIRST PLACE. 3 CERTIFICATION This is to certify that I supervised Dr Mbaeri Timothy Uzoma in carrying out the research project leading to this dissertation titled “Testicular volume measurement: Comparison of Prader orchidometer, ultrasound scan and water Displacement” Signed ......................................................................................... Prof. Mbonu O.O. MB (Lond), FRCS(Ed), FRCS(C), FWACS, FMCS. Consultant Urologist Department of Surgery Nnamdi Azikiwe University Teaching Hospital Nnewi. Signed ............................................................................................ Prof. Orakwe J.C. FMCS, FWACS Consultant Urologist Head Department of Surgery Nnamdi Azikiwe University Teaching Hospital Nnewi. Signed............................................................................................. Prof. Nwofor A.M.E. FMCS, FWACS Consultant Urologist Dean Faculty of Medicine Nnamdi Azikiwe University . -
Guidelines on Paediatric Urology S
Guidelines on Paediatric Urology S. Tekgül (Chair), H.S. Dogan, E. Erdem (Guidelines Associate), P. Hoebeke, R. Ko˘cvara, J.M. Nijman (Vice-chair), C. Radmayr, M.S. Silay (Guidelines Associate), R. Stein, S. Undre (Guidelines Associate) European Society for Paediatric Urology © European Association of Urology 2015 TABLE OF CONTENTS PAGE 1. INTRODUCTION 7 1.1 Aim 7 1.2 Publication history 7 2. METHODS 8 3. THE GUIDELINE 8 3A PHIMOSIS 8 3A.1 Epidemiology, aetiology and pathophysiology 8 3A.2 Classification systems 8 3A.3 Diagnostic evaluation 8 3A.4 Disease management 8 3A.5 Follow-up 9 3A.6 Conclusions and recommendations on phimosis 9 3B CRYPTORCHIDISM 9 3B.1 Epidemiology, aetiology and pathophysiology 9 3B.2 Classification systems 9 3B.3 Diagnostic evaluation 10 3B.4 Disease management 10 3B.4.1 Medical therapy 10 3B.4.2 Surgery 10 3B.5 Follow-up 11 3B.6 Recommendations for cryptorchidism 11 3C HYDROCELE 12 3C.1 Epidemiology, aetiology and pathophysiology 12 3C.2 Diagnostic evaluation 12 3C.3 Disease management 12 3C.4 Recommendations for the management of hydrocele 12 3D ACUTE SCROTUM IN CHILDREN 13 3D.1 Epidemiology, aetiology and pathophysiology 13 3D.2 Diagnostic evaluation 13 3D.3 Disease management 14 3D.3.1 Epididymitis 14 3D.3.2 Testicular torsion 14 3D.3.3 Surgical treatment 14 3D.4 Follow-up 14 3D.4.1 Fertility 14 3D.4.2 Subfertility 14 3D.4.3 Androgen levels 15 3D.4.4 Testicular cancer 15 3D.5 Recommendations for the treatment of acute scrotum in children 15 3E HYPOSPADIAS 15 3E.1 Epidemiology, aetiology and pathophysiology -
Highly Specific Role of the Insulin Receptor in Breast Cancer Progression
R Rostoker et al. Insulin receptor in breast cancer 22:2 145–157 Research progression Highly specific role of the insulin receptor in breast cancer progression Ran Rostoker1, Sagi Abelson2, Keren Bitton-Worms1, Inna Genkin1, Sarit Ben-Shmuel1, Maria Dakwar1, Zila Shen Orr1, Avishay Caspi1, Maty Tzukerman2 and Derek LeRoith1,3 1Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel Correspondence 2The Laboratory of Molecular Medicine, Rambam Health Care Campus and Rappaport Faculty of Medicine and should be addressed Research Institute, Technion, Haifa 31096, Israel to D LeRoith 3Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York City, Email New York, USA [email protected] Abstract Accumulating evidence from clinical trials indicates that specific targeting of the IGF1 receptor Key Words (IGF1R) is not efficient as an anti-breast cancer treatment. One possible reason is that the " hyperinsulinemia mitogenic signals from the insulin receptor (IR) can be processed independently or as " insulin receptor compensation to inhibition of the IGF1R. In this study, we highlight the role of the IR in " insulin-like growth factor 1 mediating breast tumor progression in both WT mice and a hyperinsulinemic MKR mouse receptor model by induction of Ir (Insr)orIgf1r knockdown (KD) in the mammary carcinoma Mvt-1 cell " breast cancer and CD24 line. By using the specific IR antagonist-S961, we demonstrated that Igf1r-KD induces elevated responses by the IR to IGF1. On the other hand, Ir-KD cells generated significantly smaller tumors in the mammary fat pads of both WT and MKR mice, as opposed to control cells, whereas Endocrine-Related Cancer the Igf1r-KD cells did not. -
From Prenatal Life Into Senescence, Testosterone Is Essential Requirement for Manhood
Special Article From Prenatal Life into Senescence, Testosterone is Essential Requirement for Manhood Wisuit Pradidarcheep PhD*, Udomsri Showpittapornchai PhD* * Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand Prenatally, organisms have the bipotentiality to differentiate along either male or female lines, a process with different stages, each with a narrow window of time, during which testosterone plays a pivotal role in the case of male sexual differentiation. During puberty, the body directs the masculinization process with growth of the genitalia and prostate. Body contours become male, with an average height of 10-15 centimeters greater than that of females, a greater bone and muscle mass, a male hair pattern and a male-type fat distribution. These pubertal developments, largely reversible in case of severe androgen deficiency, require adult levels of testosterone throughout life. A new area of interest is in exploring how far age-related body changes (loss of bone and muscle mass, a shift into a higher ratio of body fat/lean body mass) are part of an age-related decline of testicular testosterone production. Therefore, throughout life, testosterone is essential for a normal male life. Keywords: Aging, Bone, Penis, Sex differentiation, Skin J Med Assoc Thai 2009; 92 (4): 573-87 Full text. e-Journal: http://www.mat.or.th/journal If, as Freud stated ‘anatomy is destiny’(1), produced by the adrenal gland and in women by the then the hormone testosterone, is a key player in our ovary. In some target organs, testosterone is a pro- destinies. Indeed, testosterone determines whether hormone and its action is not mediated by testosterone we are born as a boy or a girl, and whether the former itself but by its local conversion products, 5α-dihydro- further successfully transitions from boyhood to testosterone (DHT) and/or estradiol (E2). -
EAU Guidelines on Paediatric Urology 2017
EAU Guidelines on Paediatric Urology S. Tekgül (Chair), H.S. Dogan, R. Kocvara, J.M. Nijman (Vice-chair), C. Radmayr, R. Stein Guidelines Associates: M.S. Silay, S. Undre, J. Quaedackers European Society for Paediatric Urology © European Association of Urology 2017 TABLE OF CONTENTS PAGE 1. INTRODUCTION 8 1.1 Aim 8 1.2 Panel composition 8 1.3 Available publications 8 1.4 Publication history 8 1.5 Summary of changes 8 1.5.1 New and changed recommendations 9 2. METHODS 10 2.1 Peer review 10 2.2 Future goals 10 3. THE GUIDELINE 10 3.1 Phimosis 10 3.1.1 Epidemiology, aetiology and pathophysiology 10 3.1.2 Classification systems 10 3.1.3 Diagnostic evaluation 10 3.1.4 Management 10 3.1.5 Follow-up 11 3.1.6 Summary of evidence and recommendations for the management of phimosis 11 3.2 Management of undescended testes 11 3.2.1 Background 11 3.2.2 Classification 12 3.2.2.1 Palpable testes 12 3.2.2.2 Non-palpable testes 13 3.2.3 Diagnostic evaluation 13 3.2.3.1 History 13 3.2.3.2 Physical examination 13 3.2.3.3 Imaging studies 13 3.2.4 Management 13 3.2.4.1 Medical therapy 13 3.2.4.1.1 Medical therapy for testicular descent 14 3.2.4.1.2 Medical therapy for fertility potential 14 3.2.4.2 Surgical therapy 14 3.2.4.2.1 Palpable testes 14 3.2.4.2.1.1 Inguinal orchidopexy 14 3.2.4.2.1.2 Scrotal orchidopexy 15 3.2.4.2.2 Non-palpable testes 15 3.2.4.2.3 Complications of surgical therapy 16 3.2.4.2.4 Surgical therapy for undescended testes after puberty 16 3.2.5 Undescended testes and fertility 16 3.2.6 Undescended testes and malignancy 17 3.2.7 Summary -
“We're Not Invincible”
YEAR IN REVIEW 2018 “WE’RE NOT INVINCIBLE” page 8 HORMONES AND HEALTH Thinking about the bigger picture page 14 FROM SMOKO BREAKS TO GP VISITS Andrology Australia talks prompt Lismore men to act on their health page 26 YEAR IN REVIEW 2018 Minister's foreword It is with much pleasure that I am writing the foreword for Features : Andrology Australia’s 2018 Annual Review. In 2018, I proposed - 05 - Building a leading organisation for the development of a new strategy for men’s health, the men’s health National Men’s Health Strategy 2020 -2030, to build on the National Male Health Policy released in 2010. Andrology - 05 - Spreading the message Australia led the research and development of the strategy, working in conjunction with experts from all sectors of health. - 06 - From evidence to engagement The resultant strategy is one that will act as a blueprint to ensure every man and boy in Australia is supported to live a - 08 - “We’re not invincible” long, healthy and fulfilling life. - 10 - Research & Throughout the year, Andrology Australia continued to drive an evidence- publications based approach to men’s health with high-quality education and training programs for health professionals and the provision of information to men on a range of reproductive health issues. -12 - Advisors Andrology Australia’s campaign in Men’s Health Week based on the -14 - Hormones and health theme “it’s healthy to talk” was particularly successful in engaging Thinking about the bigger picture and encouraging men to have a conversation about their health and wellbeing with someone they trust. -
Highly Specific Role of the Insulin Receptor in Breast Cancer Progression
R Rostoker et al. Insulin receptor in breast cancer 22:2 145–157 Research progression Highly specific role of the insulin receptor in breast cancer progression Ran Rostoker1, Sagi Abelson2, Keren Bitton-Worms1, Inna Genkin1, Sarit Ben-Shmuel1, Maria Dakwar1, Zila Shen Orr1, Avishay Caspi1, Maty Tzukerman2 and Derek LeRoith1,3 1Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel Correspondence 2The Laboratory of Molecular Medicine, Rambam Health Care Campus and Rappaport Faculty of Medicine and should be addressed Research Institute, Technion, Haifa 31096, Israel to D LeRoith 3Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York City, Email New York, USA [email protected] Abstract Accumulating evidence from clinical trials indicates that specific targeting of the IGF1 receptor Key Words (IGF1R) is not efficient as an anti-breast cancer treatment. One possible reason is that the " hyperinsulinemia mitogenic signals from the insulin receptor (IR) can be processed independently or as " insulin receptor compensation to inhibition of the IGF1R. In this study, we highlight the role of the IR in " insulin-like growth factor 1 mediating breast tumor progression in both WT mice and a hyperinsulinemic MKR mouse receptor model by induction of Ir (Insr)orIgf1r knockdown (KD) in the mammary carcinoma Mvt-1 cell " breast cancer and CD24 line. By using the specific IR antagonist-S961, we demonstrated that Igf1r-KD induces elevated responses by the IR to IGF1. On the other hand, Ir-KD cells generated significantly smaller tumors in the mammary fat pads of both WT and MKR mice, as opposed to control cells, whereas Endocrine-Related Cancer the Igf1r-KD cells did not. -
Testicular Cancer, Patients
Step-by-Step Male Genital Examination Testicular volume Testicular volume is assessed using an orchidometer; a sequential series of beads ranging in size from 1 mL to 35 mL (see Image 1). Conduct the examination in a warm environment, with the patient lying on their back. 1. Gently isolate the testis and distinguish it from the epididymis. Then stretch the scrotal skin, without compressing the testis. 2. Use your orchidometer to make a manual side-by-side comparison between the testis and beads (see Image 2). 3. Identify the bead most similar in size to the testis, while making allowance not to include the scrotal skin. Normal testicular volume ranges Childhood Puberty Adulthood < 3 mL 4-14 mL 15-35 mL Image 1 – Orchidometer Clinical notes • Asymmetry between testes is common (e.g. 15 mL versus 20 mL) and not medically significant. Why use an orchidometer? • Asymmetry is sometimes more marked following unilateral Testicular volume is important in the diagnosis of androgen testicular damage. deficiency, infertility and Klinefelter syndrome. • Testes are roughly proportional to body size. • Low testicular volume suggests impaired spermatogenesis1. • Small testes (< 4 mL) from mid puberty are a consistent feature of Klinefelter syndrome2. Examination of secondary sexual characteristics Gynecomastia • Gynecomastia is the excessive and persistent development of benign glandular tissue evenly distributed in a sub-areolar position of one or both breasts (see Image 3)3. • Can cause soreness and considerable embarrassment. • Common during puberty, usually resolves in later adolescence3. Image 2 – Example of 30 mL and 4 mL adult testis • Causes include increased estrogen, low testosterone, various medications, marijuana, androgen abuse and abnormal liver function3, 4, 5.