E-Table 1. Mean (SD) Differences of Change Scores, Lower : Upper 95% Confidence Intervals

E-Table 1. Mean (SD) differences of change scores, lower : upper 95% confidence intervals, and significance levels.

VARIABLES CBZ - LEV CBZ - ND L

–

D Overall Composite Score -.37 (.49) -.53 (.32) -.16 (.36)

-.56 : -.19 -.66 : -.41 -.30 : -.02

p<.001 p<.0001 p<.05 SAM Exam (cognitive- -.64 (.39) -.68 (.29) -.04 (.31) neurophysiological test score) -.79 : -.49 -.79 : -.57 -.16 : .08

p<.0001 p<.0001 Standard Neuropsychological Tests by Domains Attention/Vigilance Digit Cancellation -7.6 (39.0) -5.2 (30.5) 2.4 (25.1)

-22.8 : 7.5 -17.0 : 6.6 -7.3 : 12.2 Trial 1 Visual Serial Addition Test 0.6 (4.7) -0.5 (2.6) -1.2 (3.7)

-1.2 : 2.5 -1.5 : 0.5 -2.6 : 0.3 Trial 2 Visual Serial Addition Test -1.1 (4.9) -1.9 (4.6) -0.8 (2.8)

-3.9 : 0.8 -3.7 : -0.1 -1.9 : 0.3

p<.05 Trial 3 Visual Serial Addition Test -1.0 (4.0) -1.8 (3.6) -0.8 (3.1)

-2.6 : 0.6 -3.2 : -0.4 -2.0 : 0.4

p<.01 Trial 4 Visual Serial Addition Test -2.3 (4.9) -2.9 (4.9) -0.6 (3.3) -4.2 : -3.4 -4.8 : -1.0 -1.9 : 0.7

p<.05 p<.01 Total Visual Serial Addition Test -3.6 (11.6) -7.1 (11.1) -3.5 (8.2)

-8.2 : 0.9 -11.4 : -2.8 -6.7 : -0.3

p<.01 p<.05 Memory MCG Paragraphs: Immediate Recall 1 -1.5 (12.2) -2.3 (10.7) -0.8 ( 11.9)

-6.2 : 3.1 -6.4 : 1.9 -3.4 : 3.9 MCG Paragraphs: Immediate Recall 2 -0.4 (13.7) -2.1 (9.4) -1.7 (12.4)

-5.7 : 4.9 -5.8 : 1.5 -6.6 : 3.1 MCG Paragraphs: Delay Recall 0.4 (15.8) -1.4 (11.2) -1.8 (14.3)

-5.7 : 6.5 -5.8 : 2.9 -7.4 : 3.7 Cognitive/Motor Speed Choice Reaction Time – Initiation* 15.9 (83.1) 38.3 (76.4) 16.9 (68.7)

-17.6 : 49.5 6.1 : 70.6 -11.5 : 45.2

p<.05 Choice Reaction Time – Movement* -16.7 (90.1) -22.8 (79.2) 1.5 (78.1)

-53.1 : 19.7 -56.3 : 10.7 -30.7 : 33.7 Choice Reaction Time – Total* 0.1 (97.4) 9.1 (98.0) 12.0 (104.9)

-39.3 : 39.4 -32.3 : 50.5 -31.3 : 55.3 Grooved Pegboard* 1.9 (10.5) 2.7 (6.2) 0.8 (8.8)

-2.2 : 5.9 0.2 : 5.1 -2.6 : 4.2

p<.05 Other Cognitive Stroop: Word -4.0 (7.7) -4.4 (8.3) -0.3 (5.9)

-7.0 : -1.0 -7.6 : -1.1 -2.6 : 2.0

p<.01 p<.01 Stroop: Color -4.9 (8.1) -6.0 (6.9) -1.1 (4.2)

-8.1 : -1.8 -8.7 : -3.3 -2.7 : 0.6

p<.01 p<.0001 Stroop: Word/Color -1.5 (7.9) -2.7 (6.8) -1.3 (4.5)

-4.5 : 1.6 -5.4 : -0.1 -3.0 : 0.5

p<.05 Symbol Digit Modalities Test -1.5 (6.9) -3.8 (5.1) -2.4 (5.6)

-4.1 : 1.2 -5.8 : -1.9 -4.5 : -0.2

p<.0001 p<.05 Subjective Measures AB Neurotoxicity* 4.9 (10.1) 8.2 (8.5) 3.2 (5.8)

1.0 : 8.8 4.9 : 11.5 0.1 : 5.5

p<.05 p<.0001 p<.01 POMS – Tension* 0.8 (6.0) 2.3 (4.4) 1.5 (4.2)

-1.5 : 3.1 0.7 : 4.0 -0.1 : 3.2

p<.01 POMS – Depression* 2.5 (7.7) 3.0 (6.5) 0.4 (4.1)

-0.5 : 5.5 0.4 : 5.5 -1.2 : 2.0

p<.05 POMS – Anger* 2.1 (8.7) 2.6 (5.5) 0.6 (6.1)

-1.3 : 5.4 0.5 : 4.8 -1.8 : 2.9

p<.05 POMS – Vigor -3.5 (5.4) -5.1 (6.0) -1.6 (5.1)

-5.6 : -1.4 -7.5 : 2.8 -3.6 : 0.4

p<.01 p<.0001 POMS – Fatigue* 3.8 (6.7) 5.6 (5.0) 1.8 (5.3)

1.2 : 6.4 3.6 : 7.5 -0.3 : 3.8

p<.01 p<.0001 POMS – Confusion* 2.1 (5.2) 3.4 (4.0) 1.4 (3.7)

0.04 : 4.1 1.9 : 5.0 -0.1 : 2.8

p<.05 p<.0001 POMS – Total* 14.8 (28.5) 22.4 (24.0) 7.5 (21.6)

3.8 : 25.9 13.1 : 31.7 -0.8 : 15.9

p<.01 p<.0001 QOLIE – Attention/Concentration -7.3 (15.6) -9.6 (13.9) -2.3 (8.5)

-13.3 : -1.2 -15.0 : 4.2 -5.6 : 1.0

p<.05 p<.001 QOLIE – Language -4.4 (11.0) -5.2 (8.7) -0.8 (5.3)

-8.7 : -0.2 -8.6 : -8.2 -2.8 : 1.3

p<.05 p<.01 QOLIE – Memory -11.9 (17.5) -13.5 (12.1) -1.7 (11.0)

-18.6 : -5.1 -18.2 : -8.8 -6.0 : 2.6

p<.001 p<.0001 SEALS – Dysphoria* 1.9 (3.3) 2.2 (2.8) 0.2 (1.6)

0.6 : 3.1 1.1 : 3.2 -0.4 : 0.9

p<.01 p<.0001 SEALS – Tiredness* 1.4 (2.6) 2.1 (2.0) 0.7 (1.5)

0.4 : 2.4 1.3 : 2.8 0.1 : 1.3

p<.01 p<.0001 p<.05 SEALS – Temper* 0.3 (1.5) 0.5 (1.2) 0.4 (1.2)

-0.3 : 0.8 0.04 : 1.0 -0.2 : 0.7

p<.05 SEALS – Cognition* 3.0 (4.4) 3.5 (4.3) 0.5 (2.7)

1.3 : 4.8 1.8 : 5.1 -0.6 : 1.5

p<.001 p<.0001 SEALS – Worry* 0.2 (1.8) 0.2 (1.5) -0.2 (1.11)

-0.5 : 1.0 -0.3 : 0.8 -0.4 : 0.4 *Variables for which a positive mean difference indicates poorer performance for

first condition in pair (e.g., CBZ vs LEV); otherwise, a negative mean difference indicates poorer performance for first item in pair. Carbamazepine = CBZ;

Levetiracetam = LEV; ND = non-drug; MCG = Medical College of Georgia;

POMS = Profile of Mood States; QOLIE-89 = Quality of Life in Epilepsy-89;

SEALS = Side Effects and Life Satisfaction Scale.