US 2004O175439A1 (19) (12) Patent Application Publication (10) Pub. No.: US 2004/0175439 A1 Cyr (43) Pub. Date: Sep. 9, 2004

(54) EXTRACTS AND COMPOSITIONS (52) U.S. Cl...... 424/725; 435/7.1 COMPRISING EXTRACELLULAR PROTEASE INHIBITORS (57) ABSTRACT (76) Inventor: Benoit Cyr, Desmaures (CA) Correspondence Address: The present invention provides a plant derived extract Nath & Associates comprising inhibitory activity against one or more extracel Sixth Floor 1030 15th Street NW lular proteases which degrade human tissue matrix. More Washington, DC 20005 (US) over, the amount of inhibitory activity in an extract can be increased by Stressing the plant prior to forming an extract. (21) Appl. No.: 10/469,402 These extracts are each prepared by a Standard process and demonstrate the ability to inhibit one or more extracellular (22) PCT Filed: Mar. 4, 2002 proteases which degrade human tissue matrix. Libraries of (86) PCT No.: PCT/CA02/00285 extracts can be prepared from Stressed and non-stressed , wherein each of the extracts demonstrate inhibitory (30) Foreign Application Priority Data activity against one or more extracellular protease inhibitors. Alternatively, Semi-purified and purified inhibitory com Mar. 2, 2001 (CA)...... 2,339,081 pounds can be isolated from the extracts following Standard Publication Classification procedures. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize (51) Int. Cl." ...... A61K 35/78; G01N 33/53 the degradation due to extracellular proteases. Patent Application Publication Sep. 9, 2004 Sheet 1 of 3 US 2004/0175439 A1

Potential Plant

Pre-Harvest Treatment

Harvest Solid S1

Optional Storage Treatment

Contact Solid S1 with Solvent A Extraction Process I Separate Pre-Extract A from Solid Matter S2 Potential Pre-Extract.A

Contact Solid S2 with Solvent B Extraction Process II Separate Pre-Extract B a. from Solid Matter S3 Potential Pre-Extract B

Contact Solid S3 with Solvent C Extraction Process III Separate Pre-Extract C w from Solid Matter S4 Potential Pre-Extract C

FIGURE 1 Patent Application Publication Sep. 9, 2004 Sheet 2 of 3 US 2004/0175439 A1

Potential Pre-Extract

Separation Procedure(s)

Test Aliquots against panel of 2 or more Extracellular Proteases

Does Extract Inconclusive demonstrate inhibitory Potential Extract is an activity against one or Extract of the more extracellular Invention proteases?

Potential Extract is not an Extract of the Invention

Plant remains a Potential Plant

Entire Procedure may be repeated on Potential Plant under varied conditions

FIGURE 2 Patent Application Publication Sep. 9, 2004 Sheet 3 of 3 US 2004/0175439 A1

One or More Plants of - the Invention

Pre-Harvest Treatment

Harvest Solid S1

Optional Storage Treatment

Extraction Process I, II Process may be or II sequentially repeated

Purification Procedure(s)

Quality Control

Extract Demonstrating Inhibitory Activity Against One or More Extracellular Proteases

Prepare Formulation for Use

FIGURE3 US 2004/0175439 A1 Sep. 9, 2004

PLANT EXTRACTS AND COMPOSITIONS normal tissues, the activity of extracellular proteases is COMPRISING EXTRACELLULAR PROTEASE tightly regulated and the breakdown/production of connec INHIBITORS tive tissue is in dynamic equilibrium, Such that there is a Slow and continual turnover due to degradation and resyn FIELD OF INVENTION thesis in the extracellular matrix of adult animals. 0001. The invention pertains to the field of protease 0007. In each of these cases, matrix components are inhibitors, Specifically inhibitors of extracellular proteases. degraded by extracellular proteolytic enzymes that are Secreted locally by cells. These proteases belong to one of four general classes: many are metalloproteinases, which BACKGROUND OF THE INVENTION depend on bound Ca" or Zn" for activity, while the others 0002 The cells of tissues are generally in contact with a are Serine, aspartic and cysteine proteases, which have a network of large extracellular macromolecules that occupies highly reactive Serine, aspartate or cysteine residue in their the Spaces in a tissue between the component cells and also respective active site (Vincenti et al., (1994) Arthritis and occupies the Space between adjacent tissues. This extracel Rheumatism, 37: 1115-1126). Together, metalloproteinases, lular matrix functions as a Scaffolding on which the cells and Serine, aspartate and cysteine proteases cooperate to degrade tissue are Supported and is involved actively in regulating matrix proteins Such as collagen, laminin, and fibronectin. interaction of the cells that contact it. The principal macro 0008. Several mechanisms operate to ensure that the molecules of the extracellular matrix include the collagens degradation of matrix components is tightly controlled. (the most abundant proteins in the body) and glycosami First, many proteases are Secreted as inactive precursors that noglycans (complex polysaccharides which are usually can be activated locally. Second, the action of proteases is bonded also to protein and then termed proteoglycans). The confined to specific areas by various Secreted protease macromolecules that comprise the extracellular matrix are inhibitors, Such as the tissue inhibitors of metaloproteases produced typically by the cells in contact there with, for and the Serine protease inhibitors known as Serpins. These example, epithelial cells in contact with a basement mem inhibitors are specific for particular proteases and bind brane and fibroblasts embedded in connective tissue. tightly to the activated enzyme to block its activity. Third, 0003) The glycosaminoglycan (proteoglycan) molecules many cells have receptors on their Surface that bind pro form a highly hydrated matrix (a gel) in which elastic or teases, thereby confining the enzyme to where it is needed. fibrous proteins (such as collagen fibers) are embedded. The 0009. Many pathogenic bacteria produce extracellular aqueous nature of the gel permits diffusion of metabolically metalloproteases, of which many are Zinc containing pro required Substances between the cells of a tissue and teases that can be classified into two families, the thermol between tissues. Additional proteins that may be found in ysin (neutral) proteases and the Serralysin (alkaline) pro extracellular matrix include elastin, fibronectin and laminin. teaSeS. 0004. The term “connective tissue' refers to extracellular 0010) A number of patents and publications report the matrix plus specialised cells Such as, for example, fibro inhibition of one or more extraceliular proteases by com blasts, chondrocytes, osteoblasts, macrophages and mast pounds extracted from plants. For example, Sun et al., cells found therein. The term “interstitial tissue’ is best (1996) Phytotherapy Res., 10: 194-197, reports the inhibi reserved for an extracellular matrix that Stabilizes a tissue tion in vitro of stromelysin (MMP-3) and collagenase by internally, filling the gaps between the cells thereof. There betulinic acid extracted from Doliocarpus venuculosis. are also specialized forms of extracellular matrix (connec Sazuka et al., (1997) BioSci. Biotechnol. Biochem., 6.1: tive tissue) that have additional functional roles-cornea, 1504-1506, reports the inhibition of gelatinases (MMP-2 cartilage and tendon, and when calcified, the bones and and MMP-9) and metastasis by compounds isolated from teeth. green and black teas. Kumagai et at JP 08104628 A2, Apr. 0005. A structural form of extracellular matrix is the 1, 1996 (CA 125: 67741) reports the use of flavones and basal lamina (basement membrane). Basal laminae are thin anthocyanines isolated from Scutellaris baican lensis roots Zones of extracellular matrix that are found under epithelium to inhibit collagenase. Gervasi et al., (1996) Biochem. Bio or Surrounding, for example, muscle cells or the cells that phys. Res. Comm., 228: 530-538, reports the regulation of electrically insulate nerve fibres. Generally Speaking, basal MMP-2 by some plant lectins and other saccharides. Dubois laminae Separate cell layers from underlying Zones of con et al., (1998) FEBS Lett., 427: 275-278, reports the increased nective tissue or Serve as a boundary between two cell layers secretion of deleterious gelatinase-B (MMP-9) by some wherein a basal lamina can Serve as a pathway for invading plant lectins. Nagase et al.(1998) Planta Med., 64: 216-219, cells associated with pathologic processes, or for Structural reports the weak inhibition of collagenase (MMPs) by organisation associated with tissue repair (i.e. as a blueprint delphinidin, a flavonoid isolated from Solanum melongena. from which to regenerate original tissue architecture and 0011. Other reports discuss the use of extracts to inhibit morphology). extracellular proteases. For example, Asano et al., (1998) 0006 The regulated turnover of extracellular matrix mac Immunopharmacology, 39: 117-126, reports the inhibition romolecules is critical to a variety of important biological of TNF-C. production using Tripterygium wilfordii Hook F. processes. Localised degradation of matrix components is extracts. Maheu et al., (1998) Arthritis Rheumatol., 41: required when cells migrate through a basal lamina, as when 81-91, reports the use of avocado/Soybean non-Saponifiable white blood cells migrate across the vascular basal lamina extracts in the treatment of arthritis. Makirnura etal., (1993) into tissues in response to infection or injury, or when cancer J. Periodontol., 64: 630-636, also reports the use of green tea cells migrate from their site of origin to distant organs via the extracts to inhibit collagenases in vitro. Obayashi et al., bloodstream or lymphatic vessels, during metastasis. In (1998) Nippon Keshonin Gijutsusha Kaishi, 32: 272-279 US 2004/0175439 A1 Sep. 9, 2004

(CA 130: 92196) reports the inhibition of collagenase-I organic. They are generally applied in a polar to non-polar (MMP-1) from human fibroblast and neutrophil elastase by order. They can be applied in a non-polar to polar order, plant extract from Eucalyptus and Elder. however, in each case the Solid matter must be dried prior to 0012. When a plant is stressed, several biochemical pro contacting the Solid matter with the Subsequent Solvent. ceSSes are activated and many new chemicals, in addition to 0019 FIG. 2 describes in further detail, one standard those constitutively expressed, are Synthesised as a response. procedure that is followed in order to generate the extracts These chemicals include enzymes, enzyme inhibitors (espe of the invention. cially protease inhibitors), lectins, alkaloids, terpenes, oli gosaccharides, and antibiotics. The biosynthesis of these 0020 FIG. 3 presents an overview of one example of a defense chemicals and Secondary metabolites is not yet fully commercial procedure that could be followed to prepare understood. The most Studied System is the production of extracts of the invention. protease inhibitors following pest attack or mechanical 0021 Table 1 reports the inhibition of human MMP-1 by wounding. On the other hand, Several inducible chemicals aqueous (A), ethanolic (R) and organic (S) extracts for are the products of complex biochemical pathways which exemplary Stressed and non-stressed plant Sources. require Several biosynthetic enzymes to be activated. 0022 Table 2 reports the inhibition of human MM-2 by 0013. It has been shown that many chemicals can be used aqueous (A), ethanolic (R) and organic (S) extracts for to “stress' plants and to artificially stimulate biosynthesis of exemplary Stressed and non-stressed plant Sources. Several new and constitutive defense chemicals. Also, dif ferent types of StreSS can activate distinct metabolic defense 0023 Table 3 reports the inhibition of human MMP-3 by pathways, thereby leading to production of a variety of aqueous (A), ethanolic (R) and organic (S) extracts for chemicals. Although the various biosynthetic defense path exemplary Stressed and non-stressed plant Sources. ways share Some similarities, these pathways are character 0024) Table 4 reports the inhibition of human MMP-9 by istic of Specific plant . Therefore, treating many aqueous (A), ethanolic (R) and organic (S) extracts for plants with many types of StreSS can lead to a vast number exemplary Stressed and non-stressed plant Sources. of collections of diverse chemicals from plant origin. 0025 Table 5 reports the inhibition of human Cathepsin 0.014. In addition to pests, fungi, and other pathogenic B by aqueous (A), ethanolic (R) and organic (S) extracts for attacks, Stressors include drought, heat, water and mechani exemplary Stressed and non-stressed plant Sources. cal wounding. Furthermore, many chemicals can act as StreSSors that activate gene expression; these include: hydro 0026 Table 6 reports the inhibition of human Cathepsin gen peroxide, OZone, Sodium chloride, jasmonic acid and D by aqueous (A), ethanolic (R) and organic (S) extracts for derivatives, C-linoleic acid, Y-linoleic acid, Salicylic acid, exemplary Stressed and non-stressed plant Sources. abscesic acid, Volicitin, Small oligopeptides, among others. 0027 Table 7 reports the inhibition of human Cathepsin 0.015 The use of abiotic stressors on plants has been the G by aqueous (A), ethanolic (R) and organic (S) extracts for focus of intense Studies in plant Science. Artificial Stresses exemplary Stressed and non-stressed plant Sources. have been used to Stimulate the production of natural plant protease inhibitors for insect digestive proteases, in order to 0028 Table 8 reports the inhibition of human Cathepsin enhance crop protection against certain pests and herbivores. L by aqueous (A), ethanolic (R) and organic (S) extracts for They have proven useful in combination with plants geneti exemplary Stressed and non-stressed plant Sources. cally modified to express other protease inhibitor genes. 0029) Table 9 reports the inhibition of human Cathepsin Finally, in the area of molecular farming, Stresses have been K by aqueous (A), ethanolic (R) and organic (S) extracts for used to Stimulate gene expression in plants genetically exemplary Stressed and non-stressed plant Sources. modified to include an inducible coding Sequence for a 0030 Table 10 reports the inhibition of HLE by aqueous protein of nutraceutical and/or medicinal interest (Ryan and (A), ethanolic (R) and organic (S) extracts for exemplary Farmer, U.S. Pat. No. 5,935,809). Stressed and non-stressed plant Sources. 0016. Likewise, the use of gene activators or elicitors have been described to enhance the production of volatile 0031 Table 11 reports the inhibition of bacteria Clostri chemicals in plant cell cultures. These elicitors have been pain by aqueous (A), ethanolic CR) and organic (S) extracts demonstrated to induce the activity of Several enzymes Such for exemplary Stressed and non-Stressed plant Sources. as for example phenylalanine ammonia lyase, therefore 0032 Table 12 reports the inhibition of bacteria Subtilisin leading to an increase in the production of plant volatile by aqueous (A), ethanolic (R) and organic (S) extracts for components. exemplary Stressed and non-stressed plant Sources. 0017 No one has used stress to improve or modify plants human protease inhibitor content. SUMMARY OF THE INVENTION BRIEF DESCRIPTION OF THE FIGURES AND 0033. In one aspect the invention provides n extract from a plant, which inhibits the activity of one or more extracel TABLES lular proteases, wherein the extract has been prepared by the 0.018 FIG. 1 presents an overview of one standard pro Steps of harvesting plant material, treating plant material cedure that is followed in order to generate the extracts of with a Solvent, Separating the resulting extract from the Solid the invention each of which is derived from the solid plant material. testing an aliquot of the extract against a panel of material. Solvent A, B and C generally represent Separate extracellular proteases, and retaining the extract if it inhibits classes of Solvents, for example, aqueous, alcoholic and the activity of one or more extracellular proteases an extract. US 2004/0175439 A1 Sep. 9, 2004

0034. In one aspect the invention provides a library of three or more extracellular proteases. In one embodiment, an extracts from plants wherein each extract inhibits the activ extract of the invention demonstrates inhibitory activity ity of one or more extracellular proteases. against four or more extracellular proteases. The Solvent 0035) In another aspect the invention provides a library of may be evaporated leaving a Solid embodiment of the plant extracts formed by a process comprising: contacting extract. In one embodiment, the inhibitory activity is greater plant material with either an aqueous, ethanolic, or an than about 20% when measured according to one of the organic Solvent, isolating an extract from Said plant material; assays as described herein. In one embodiment a panel of analysing Said extract for the presence of one or more extracellular proteases can be used to test the inhibitory inhibitory activities against an extracellular protease; and activity of the extract. collected together, So as to form a library of plant extracts 0045 “Panel of Extracellular Proteases” means the array wherein each extract inhibits one or more extracellular of distinct extracellular proteases that are used to perform proteases. routine assays to monitor the presence or absence of inhibi 0036). In one aspect the invention provides an extract tory activity throughout the extraction process of the inven from a plant, which inhibits the activity of one or more tion. In one embodiment, inhibitory activity against one or extracellular proteases, wherein Said plant has been Stressed more extracellular proteases is monitored; in one embodi prior to generating the extract. ment, inhibitory activity against two or more extracellular proteases is monitored; in one embodiment inhibitory activ 0037. In a further aspect the invention provides a library ity against three or more extracellular proteases is moni of extracts derived from plants wherein each extract inhibits tored; in one embodiment inhibitor activity against four or the activity of one or more extracellular proteases and more extracellular proteases is monitored; in one embodi wherein Said plants have been Stressed prior to generating ment inhibitory activity against five or more extracellular the extract. proteases is monitored. One skilled in the art would appre 0.038. In yet a further aspect provides an extracellular ciate that as high throughput Screening techniques develop, protease inhibitor derived from a plant comprising the Steps one could routinely assay the fractions of the extracts with as of contacting plant material with either an aqueous, ethan many extracellular proteases as the technology permits. In olic, or an organic Solvent, isolating an extract from Said general, the more enzymes that can be routinely tested the plant material; analysing Said extract for the presence of one more information that can be generated during this process or more inhibitory activities against a panel of extracellular that will be useful for defining extracts useful to inhibit proteases, further purifying a compound from Said extract if extracellular proteases. Said extract demonstrates the inhibition of one or more 0046 “Potential plants” includes all species of the King extracellular proteases greater than about 20%. dom Plantae, including plants under the Division Chloro 0039. In another aspect the invention provides a method phyta, Division Rhodophora, Division Paeophyta, Division for increasing the levels of extracellular protease inhibitors Bryophyta and Division Tracheophyta; Subdivision Lycop in plants comprising the Step of Stressing the plant prior to sida, Subdivision Sphenopsida, Subdivision Pteropsida and Subdivision Spermopsida; Class Gymnospermae, Class forming a plant extract. Angiospermae, Subclass Dicotyledonidae and Subclass 0040. In another aspect the invention provides for the use Monocotyledonidae. In general terms, all plants, herbs, and of Such extracts during protein purification to minimize the lower plants Such as fungi and algae. Potential plants are degradation due to extracellular proteases. those plants that can be Subjected to the methodology of the invention in order to generate an extract which.can then be DETAILED DESCRIPTION OF THE tested against a panel of extracellular proteases. Those plants INVENTION which yield an extract demonstrating inhibitory activity against an extracellular protease are considered to be plants 0041) Definitions and extracts comprising the Subject matter of the invention. 0.042 Unless defined otherwise, all technical and scien 0047. “Potential Pre-Extract” means an extract which has tific terms used herein have the same meaning as commonly not yet been determined to posess inhibitory activity against understood by one of ordinary skill in the art to which this one or more extracellular proteases. invention belongs. 0048 “Plant material” means any part of a plant taken 0.043 “Extracellular protease” means enzymes which indivudually or in group, could include but not restricted to degrade proteins (proteases) Secreted outside the cell. leafs, , roots, , Stems, and other part of a plant, Included MMPs, cathepsins, elastase, plasmin, TPA, uPA, wherein a plant may be terrestrial, aquatic or other. kallikrein, ADAMS family members, neprilysin, gingipain, cloStripain, thermolysin, Serralysin,and other bacterial and 0049) “Protease inhibitor” as used herein, refers to any Viral enzymes. compound that attenuates the proteolytic activity of pro 0044) “Extract of the invention,” means an a composition teases. “Protease inhibitor” may or may not be proteina prepared by contacting a Solvent with plant material, pro CCOS. duced following the procedures of the invention, which 0050 “Stressor” as used herein, refers to any physical demonstrates inhibitory activity against one or more extra StreSS, chemical compound, or a biological agent used to cellular proteases. In one embodiment an extract of the elicit production of extricellular protease inhibitors as a invention demonstrates inhibitory activity against two or result of activation of a defence response in a plant. Elicitors more extracellular proteases. In one embodiment an extract and inducers are also considered to be StreSSors. Any mate of the invention demonstrates inhibitory activity against rial of a plant may be contacted with a stressor, elicitor, or US 2004/0175439 A1 Sep. 9, 2004 inducer, which is a chemical compound, for example organic Species. Then a pre-harvest treatment is Selected, wherein aand inorganic acids, fatty acids, glycerides, phospholipids, either treatment with water, or water in addition to any glycolipids, orgnaic Solvents, amino acids,a nd peptides, combination of a StreSS, wherein the StreSS can be applied monosaccharides, oligosaccharides, polysaccharides and Separately from the water (if the stress is drought, then the lipopllysaccharides, phenolics, alkaloids, terpenes and ter water would not be provided for the period in which the penoids, antibiotics, detergents, polyamines, peroxides, plant is to be stressed); followed by choosing whether the ionophores, etc., or Subjected to a physical treatment, Such treated plant will be treated for Storage and Stored prior to as ultraViolet radiation, low and high temperature StreSS, contacting plant material with the first Solvent. The plant oSmotic StreSS induced by Salt or Sugars, nutritional StreSS material is treated with the first solvent and then the liquid defined as depriving the plant of essential nutrients (N, P, or is separated from the solid material (solid S2), wherein the K), in order to induce or elicit increased production of one liquid becomes Fraction F1 or Pre-Extract A. The solid S2 or more chemicals. Such chemical compound or physical is treated with the Second Solvent and then the liquid is treatment may be applied continuously or intermittently to separated from the solid material (Solid S3), wherein the the plant or plant parl In one embodiment, Such treatment liquic becomes Fraction F2 or Pre-Extract B. The solid S3 is may be accomplished by contacting the plant material with treated with the third solvent and then the liquid is separated a Solution containing the elicitor or by irradiating the plant from the solid material (Solid S4). material or exposing the plant material to other environmen 0.055 Plant Material tal StreSSes Such as temperature Stresses. 0056. In one embodiment, plants that may be employed 0051) The term “substantially purified” or “substantially in the invention comprise: AbelmOSchus esculentus, Abies pure' or "isolated,” when used in reference to a molecule balsamea, Abies lasiocarpa, Achillea millefolium, Achillea having protease inhibitor activity, means that the molecule is tomentOSa, AcOnitum napellus, Aconitum spp., Acorus cala in a form that is relatively free of proteins, nucleic acids, mus, Actaea racemosa, Actinidia arguta, Actinidia Chinen lipids, carbohydrates or other materials with which it is Sis, Adiantum pedatum, Adiantum tenerum, AeSculus hip naturally associated in a planl AS disclosed herein, a plant pOcaStanum, Aframomum melegueta, AgaricuS bisporus, extract of the invention is considered to be Substantially AgaStache foeniculum, Ageratum conyzoides, Agrimonia purified. In addition, the molecules having protease inhibitor eupatoria, Agropyron cristatum, Agropyron repenS, AgrOS activity can be further purified using routine and well known tis alba, Agrostis Stolonifera; Alcea rosea, Alchemilla mol methods as provided herein. AS Such, a Substantially pure lis, Alkanna tinctoria, Allium ampeloprasum, Allium cepa, protease inhibitor of the invention can constitute at least Allium fistulosum, Allium grande, Allium porrum; Allium about one or a few percent of a Sample, for example, at least Sativum, Allium Schoenoprasum, Allium tuberosum, Allium about five percent of a Sample, generally at least about victorialis, Aloe vera, Alpinia Oficinarum, Althaea Ofici twenty percent of a Sample, and can be further purified to nalis, Amaranthus caudatus, Amaranthus retroflexus, Ama constitute at least about fifty percent of a Sample, generally ranthus tricolor; Ambrosia artemisiifolia, Amelanchierani at least about eighty percent of a Sample, and particularly folia, Amelanchier Canadensis, Amelanchier Sanguinea, about ninety percent or ninety-five percent or more of a Amelanchier SanguineaxA. laevis, AmSOnia tabernaemon Sample. A determination that a protease inhibitor of the tana, Ananas COmoSuS, Anaphalis margaritacea, Anethum invention is Substantially pure can be made using methods as graveOlens, Angelica archangelica, Angelica dahurica, disclosed herein or otherwise known in the art, for example, Angelica Sinensis, Anthemis tinctoria, Anthoxanthum Odo by performing electrophoresis and identifying the particular ratum, Anthriscus cerefolium, Anthurium guildingii, Apium molecule as a relatively discrete band. graveOlens, Apocynum cannabinum, Arachis hypogaea, 0.052 Other chemistry terms herein are used according to Aralia cordata, Aralia nudicaulis, Arctium lappa, Arctium conventional usage in the art, as exemplified by The minus, ArctOStaphyloSuva-ursi, Armoracia rusticana, Aro McGraw-Hill Dictionary of Chemical Terms (ed. Parker, S., nia melanocarpa, Aroniaxprunifolia, Arrhenatherum ela 1985), McGraw-Hill, San Francisco, incorporated herein by tius, Artemisia abrotanum, Artemisia absinthium, Artemisia reference). dracunculus, Artemisia ludoviciana, Artemisia vulgaris, Asarum europaeum, ASclepias incarnata, Asclepias tube 0053. The subject invention involves extracts from the rOSa, Asparagus Oficinalis; ASter spp., A.Stilbexarendsii, tissueS of plant species which provide inhibitory activity AStilboides tabularis, Athyrium asperum, Atriplex horten against extracellular proteases. In one embodiment, the sis, Atropa belladonna, Avena Sativa, Averrhoa carambola, present invention relates to the use of plants to produce Baptisia tinctoria, Beckmannia erucifomis, Begonia convol extracts or Semi-purifiedlpurified compounds, compositions vulacea, Begonia emini, Begonia glabra, Begonia mannii, and formulations demonstrating an inhibitory activity Begonia polygonoides, Bellis perennis, Berberis vulgaris, against one or more proteases involved in the proteolytic Beta vulgaris, Betula alleghaniensis, Betula glandulosa, degradation of human extracellular matrix. Such extracts, Boesenbergia rotunda, Boletus edulis, Borago Oficinalis, compounds, compositions and formulations derived from Brassica cepticepa, Brassica juncea, Brassica napus, Bras plant Sources, optionally fromrk water, ethanol or organic Sica nigra, Brassica Oleracea, Brassica rapa, Bromus iner extracts prepared from Said plant tissues, and fractions mis, Buddleja davidii; Bupleurum falcatum, Butomus Separable from Said extracts by chromatography or centrifu umbellatus, Caladium spp., CalamagroStis arundiflora, gal ultra-filtration or other means. In one aspect, these Calamintha nepeta, Calendula Oficinalis, Camellia Sinen extracts with inhibitory activity can be used during protein Sis, Campanula rapunculus, Canna indica, Cantharellus purification to minimize the degradation due to extracellular cibarius, CapSella bursa-pastoris, Capsicum annuum, Cap proteases. Sicum frutescenS, Carex morrowii, Carica papaya, Cartha 0.054 With reference to FIG. 1, the process for producing muS tinctorius, Carum carvi, Carya COrdiformis; Castanea an extract of the invention begins with choosing a plant spp., Centaurea Solstitialis, CeraStium tomentOSum, US 2004/0175439 A1 Sep. 9, 2004

Chaerophyllum bulbOSum; Chamaemelum nobile, Chelido Melissa Oficinalis, Mentha arvensis, Mentha pullegium, nium majus, Chenopodium album, Chenopodium bonus Mentha Spicata, Mentha Suaveolens, Menthaxpiperita, henricus, Chenopodium quinoa, Chrysanthemum coro Menyanthes trifoliata, Microlepia platyphylla, Miscanthus narium, Cicer arietinum, Cichorium endivia Subsp. endivia, Sacchariflorus, Miscanthus Sinensis, Momordica charantia, Monarda didyma, Monarda fistulosa; Monarda spp., MuSax Cichorium intybus, Cinnamomum verum, Cirsium arvense, paradisiaca, Myrica pensylvanica, NaSturtium Oficinale, Cissus discolor, Citrullus colocynthis, Citrullus lanatus, Nepeta cataria, Nicotiana rustica, Nicotiana tabacum, Citrus limettoides; Citrus limon, Citrus reticulata, Citrus Nigella Sativa, Ocimum Basilicum, Oenothera biennis, Sinensis, Citrusxparadisi; Clematisarmandii; Clematis chi Onobrychis viciifolia, Ophiopogon japonicus, Opuntia spp.; isanensis, caracasana, COCOS nucifera, Coix Origanum majorana, Origanum vulgare, Oryza Satival, lacryma-jobi, Colocasia spp., Convallaria majalis, Conyza Oxalis deppei; Oxyria digyna, Paeonia rubra, Paeonia spp.; canadensis, Corchorus Olitorius; Coriandrum Sativum, Cor Panax quinquefolius, Panicum miliaceum, Passiflora cae nus Canadensis, Cornus maS, COSmoS Sulphureus, CotinuS rulea, Passiflora spp., Pastinaca Sativa, Pennisetum alope coggygria, Crataegus Sanguinea; Crataegus spp., Cratae curoides; Perilla frutescens, Persea americana, Petasites japonicus, PetroSelinum crispum, Peucedanum cervaria, guS Submollis, Crithmum maritimum, Cryptotaenia Peucedanum Oreaselinum, Pfafia paniculata, Phacelia tan canadensis, Cucumis anguria, Cucumis melo, Cucumis acetifolia, Phalaris arundinacea, Phalaris canariensis, metuliferus, Cucumis Sativus, Cucurbita maxima, Cucur Phaseolus acutifolius; Phaseolus coccineus; Phaseolus vul bita text missing or illegible when filed Curcuma garis, Philadelphus coronarius; Phleum pratense, Phlox Zedoaria, Cydonia Oblonga, Cymbopogon citratus, Cymbo paniculata, Phoenix dactylifera; Physalis grisea; Physalis pogon martinii, Cynara cardunculus Subsp. cardunculus, philadelphica; Physalis spp., Physostegia virginiana, Phy Cyperus esculentus, Dactylis glomerata, Datisca canna tolacca americana, Pimpinella anisum, Pisum Sativum, bina, Datura metel Datura Stramonium, Daucus carota, Plantago coronopus, Plantago major, Plectranthus frutico Digitalis purpurea, Dimocarpus longan, DioSCOrea batatas, SuS; Plectranthus spp., Pleurotus spp., Plumbago zeylanica, Diospyros kaki, Dipsacus sativus, Dirca palustris, DolichoS Poa compressa, Poa pratensis, Podophyllum peltatum, lablab, Dryopteris filix-mas, Echinacea purpurea, Echi Polygonatum Odoratum, Polygonum aviculare, Polygonum nochloa frumentacea, Eleusine coracana, Equisetum hye chinense, Polygonum pensylvanicum, Polygonum persi male, ErigerOn Speciosus, Eriobotrya japonica, Eruca veSi caria, Pongamia pinnata, Pontederia Cordata, Populus caria, Erysimum perofskianum, Eschscholzia californica, incrasSata, Populus tremula, Populusxpetrowskyana, Fagopyrum esculentum, Fagopyrum tataricum, Festuca Portulaca oleracea, Potentila anSerina, Poterium San rubra, rubra, Filipendula ulmaria, Filipen guisorba, Primula veris, Prunella vulgaris, Prunus arne dulla vulgaris, Foeniculum vulgare, Forsythiaxintermedia; niaca, Prunus cerasus, Prunus persica; Prunus spp., Prunus Fortunella spp.; Fragariaxananassa, Frangula alnus, tomentOSa; PsathyroStachys juncea, Psidium guajava, Fucus vesiculosus, Fumaria Oficinalis, Galin Soga quadr Psidium spp.; Pteridium aquilinum, Pulmonaria Oficinalis, iradiata, Galium Odoratum, Gaultheria hispidula, Gaulth Pulmonaria Saccharata, Punica granatum, Pyrus commu eria procumbens, Genista multibracteata, Gentiana lutea, nis, Pyrus pyrifolia, Raphanus raphanistrum, Raphanus Gentiana macrophylla, Geum rivale, Ginkgo biloba; Sativus, Rehmannia glutinosa, Reseda luteola, Reseda Odo Glechoma hederacea, Glyceria maxima, Glycine max; Gly rata, Rheum Oficinale, Rheum palmatum, Rheumxhybri cyrrhiza glabra, Gossypium herbaceum, Guizotia abys dum, Rhus aromatica; Rhus trilobata, Ribes grossularia, Sinica, Hamamelis virginiana, HedeOma pullegioides, Hedy Ribes nigrum, Ribes rubrum; Ribes SylveStre, Ribes uva chium spp., Helianthus annuus, Helianthus Strumosus, crispa, RibeSXnidigrOlaria, Ricinus communis, Rosa rug Helianthus tuberosus, Helichrysum angustifolium, Heli Osa, Rosmarinus officinalis, Rubus allegheniensis, Rubus chrysum thianschanicum, Heliotropium arborescens, Helle canadensis, Rubus idaeus, Rubus Occidentalis, Rubus thi borus niger, Herba Schizonepetae, Hibiscus cannabinus; betanus, Rumex acetosa, Rumex acetoSella, Rumex crispus, Hordeum hexaStichon, Hordeum vulgare, Hordeum vulgare Rumex patientia, Rumex Scutatus, Ruta graveolens, Sac Subsp. vulgare, Houttuynia cordata, Humulus lupulus, charum Officinarum, Salix purpurea, Salvia elegans, Salvia Hydrastis Canadensis; Hylotelephium spp., HymenoxyS Oficinalis, Salvia Sclarea, Salvia Sylvestris, Sambucus hoopesi, HyOScyamus niger, Hypericum henryi, Hypericum canadensis, Sambucus ebulus, Sambucus nigra, San perforatum, Hypericum spp., Hypomyces lactifluorum, HyS guisorba minor, Sanguisorba Oficinalis, Santolina chamae Sopus officinalis, Iberis amara, Iberis Sempervirens, Inula cyparissus, Saponaria Oficinalis, Satureja hortensis, Sat helenium, Ipomoea batatas; Iris versicolor, Isatistinctoria, ureja montana, Satureja repandra, Scolymus hispanicus, JefferSonia diphylla, Juglans nigra, Juniperus communis, Scorzonera hispanica, Scrophularia nodosa, Scutellaria Kochia Scoparia, Koeleria glauca, Kolkwitzia amabilis, lateriflora, Secale cereale, Sechium edule, Senecio vul Krameria lappacea, Lactuca Sativa, Lactuca Serriola, garis, Serenoa repenS, Serratula tinctoria, Sesamum indi Laportea Canadensis, LaSerpitium latifolium, Lathyrus Sati cum, Setaria italica, Sidalcea spp., Silene vulgaris, Silybum vus, Lathyrus SylveStris, Laurus nobilis, Lavandula angus marianum, Sinapis alba Subsp. alba, Sium Sisarum, tifolia, Lavandula latifolia, Ledum groenlandicum, Lens Solanum dulcamara, Solanrum melongena, Solanum Sca culinaris Subsp. culinaris, LentinuS edodes, Leonurus car brum, Solanum tuberOSum, Solidago Canadensis; Solidago diaca, Lepidium Sativum, Leucanthemum vulgare, Levisti spp., Solidago virgaurea, Solidagoxhybrida, Sonchus Olera cum Oficinale, Ligularia dentata, LiguStrum vulgare, ceus, Sorghum bicolor, Sorghumx.drummondii; Spinacia Linaria vulgaris, Lindera benzoin, Linum usitatis.Simum, Oleracea, Stachys affinis, Stachys byzantina, Stachys mac Litchi chinensis, Lolium multiflorum, Lolium perenne, rantha, Stellaria graminea, Stellaria media, Stipa capillata, LOnicera ramOSissima, LOnicera Syringantha, Lotus cor Symphytum officinale, Tamarindus indica, Tanacetum bal niculatus, Lotus tetragonolobus, Lunaria annua, Lupinus Samita, Tanacetum balsamita Subsp. balsamita, Tanacetum polyphyllus, Luzula Sylvatica, Lychiis chalcedonica, Lyco cinerariifolium, Tanacetum parthenium, Tanacetum vul persicOn eSculentum, LycopersicOn pimpinellifolium, Lysi gare, Taraxacum Oficinale, Tetradenia riparia, Teucrium machia clethroides, Lythrum Salicaria, Madia Satiya, Mag chamaedrys, Thalictrum aquilegiifolium, Thlaspi arvense, nolia Stellata, Malus hupehensis, Malus prunifolia; Malus Thuja Occidentalis, Thymus fragantissimus, Thymus herba spp.; Malva text missing or illegible when filed Ma barona, Thymus praecox. Subsp. arcticus, Thymus pseudola tricaria recutita; Matricaria spp., Medicago Sativa, Mela nuginosus, Thymus Serpyllum, Thymus vulgaris, ThymusX leuca alternifolia, Melilotus albus, Melilotus officinalis, citriiodorus, Tiarella cordifolia; Tiarella spp., Tragopogon US 2004/0175439 A1 Sep. 9, 2004 porrifolius, Tragopogon spp., TrichoSanthes kirilowii; Tri taceae-Water-poppy family Order Hydrocharitales Family folium hybridum, Trifolium incarnatum, Trifolium pannoni Hydrocharitaceae-Tape-grass family Order Najadales cum, Trifolium pratense, Trifolium repens, Trigonella foe Family Aponogetonaceae-Cape-pondweed family Family num-graecum, Triticum aestivum, Triticum aestivum Subsp. Cymodoceaceae-Manatee-grass family Family Juncagi spelta, Triticum turgidium, TrolliusXcultorum, Tropaeolum majus, Tsuga Canadensis, Tsuga diversifolia, Tsuga merten naceae-Arrow-grass family Family Najadaceae-Water Siana, TuSSilago farfara, Typha latifolia, Ulmus americana, nymph family Family Posidoniaceae-Posidonia family Urtica dioica, Uvularia perfoliata, Vaccinium angustifo Family Potamogetonaceae-Pondweed family Family Rup lium, Vaccinium corymbosum, Vaccinium macrocarpOn, piaceae-Ditch-grass family Family Scheuchzeriaceae Valeriana Oficinalis, Valerianella locusta, Veratrum viride, Scheuchzeria family Family Zannichelliaceae-Horned Verbascum thapsus, Verbena Oficinalis, Veronica Oficina pondweed family Family Zosteraceae-Eel-grass family lis, Viburnum opulus, Vicia faba, Vicia Satiya, Vicia villosa, Vigna angularis, Vigna mungo, Vigna unguiculata, Vinca Subclass Arecidae Order Arales Family Acoraceae-Cala minor; Vitis spp., Weigela coraeensis, Weigela hortensis, mus family Family Araceae-Arum family Family Lem Withania Somnifera;xTriticosecale spp.; Xanthium Sibiri naceae-Duckweed family Order Arecales Family cum, Xanthium Strumarium, Yucca filamentOSa; Zea mayS, Arecaceae-Palm family Order Cyclanthales Family Cycla Zingiber Oficinale, Achillea ptarmica, Ajuga reptans; ASter nthaceae-Panama Hat family Order Pandanales Family spp.; AStilbe chinensis, BergeniaxSchmidtii, Brassica chin Pandanaceae-Screw-pine family Subclass Commeinidae ensis, Butomus umbellatus, Buxus microphylla, Carpinus Order Commelinales Family Commelinaceae-Spiderwort caroliniana, Centaurea dealbata, ChaenomeleSXSuperba, family Family Mayacaceae-Mayaca family Family Xyri Clematis alpina, Coreopsis verticillata, Comus alba, Comus Sericea, Corylus maxima, Crambe COrdifolia, Cype daceae-Yellow-eyed Grass family Order Cyperales Family rus altemifolius, Dahlia spp.; Euphorbia amygdaloides; Cyperaceae-Sedge family Family Poaceae-Grass family Fuchsia spp., Fuchsia magellanica, Galium aparine, Gera Order Eriocaulales Family Eriocaulaceae-Pipewort family nium Sanguineum, Geranium phaeum, Geranium pratense, Order Juncales Family Juncaceae-Rush family Order Res Geranium Sanguineum, Geraniumxcantabrigiense, Glaux tionales Family Joinvilleaceae-Joinvillea family Order Maritima, Hamamelis mollis, Hedychium coronarium; Typhales Family Sparganiaceae-Bur-reed family Family Helenium spp.; Herba Schizonepetae, Hosta Sieboldiana, Typhaceae-Cat-tail family Subclass Liliidae Order Hydrangea quercifolia, Ipomoea aquatica, LamiaStrum Family Agavaceae-Century-plant family Family galeobdolon, Magnoliaxloebneri; Malva verticillata, Mat teuccia pensylvanica, Microbiata decuSSata, Montia perfo Aloeaceae-Aloe family Family DioScoreaceae-Yam fam liata, Ocimum tenuiflorum, Oenothera fruticosa Subsp fru ily Family Haemodoraceae Bloodwort family Family ticosa, Onoclea Sensibilis, paeonia Suffruticosa, Penstemon Hanguanaceae-Hanguana family Family Iridaceae-Iris digitalis, Petasites japonicus, Physalis alkekengi; Pinus family Family -Lily family Family Phily cembra, Pinus mugo, Potentilla fruticosa; Rhododendron draceae-Philydraceae family Family Pontederiaceae-Wa spp., ribes americanum; Rodgersia spp., Rodgersia podo ter-Hyacinth family Family Smilacaceae-Catbrier family phylla, Rubus arcticus, Rubus phoenicolasius, Rubus pube Family Stemonaceae-Stemona family Family Taccaceae Scens; Rudbeckia maxima, Sempervivum tectorum, Soleiro Tacca family Order Orchidales Family Burmanniaceae lia Soleirolii; Solidago caesia, Staphylea trifolia, Burmannia family Family Orchidaceae-Orchid family Stephanandra incisa; Stewartia pseudocamellia, Strelitzia reginae, SymphoricarpOS Orbiculatus, SymphoricarpOS Subclass Zingiberidae Order Bromeliales Family Bromeli albus, TaxusXmedia, Vernonia gigantea, Veronica austriaca aceae-Bromeliad family Order Zingiberales Family Can Ssp teucrium, Veronica beccabunga, Viburnum plicatum. naceae -Canna family Family Costaceae-Costus family Family Heliconiaceae-Heliconia family Family Maranta 0057. It is further contemplated by this invention that any ceae-Prayer-Plant family Family Musaceae-Banana fam plant may be employed in the method as a potential plant. ily Family Zingiberaceae-Ginger family Class Magnoli For example, plants belonging to the following classifica opsida-Dicotyledons Subclass Asteridae Order tions may optionally be employed in order to prepare an Family -Aster family Order Callitrichales Fam extract of the invention when Such extracts are demonstrated ily Callitrichaceae-Water-starwort family Family Hippuri to poseSS inhibitory activities against extracellular proteases: daceae-Mare's-tail family Order Calycerales Family Superdivision Spermatophyta- plants Division Conif Calyceraceae-Calycera family Order Campanulales Fam erophyta- Class Pinopsida Order Family ily Campanulaceae-Beilflower family Family Goodeni Araucariaceae-Araucaria family Family Cephalotax aceae-Goodenia family Family Sphenocleaceae-Speno aceae-Plum Yew family Family Cupressaceae-Cypress clea family Order Dipsacales Family Adoxaceae family Family -Pine family Family Podocar Moschatel family Family Caprifoliaceae-Honeysuckle paceae-Podocarpus family Family Taxodiaceae-Red family Family Dipsacaceae-Teasel family Family Valeri wood family Order Taxales Family Taxaceae-Yew family anaceae-Valerian family Order Gentianales Family Apo Division Cycadophyta-Cycads Class Cycadopsida Order cynaceae-Dogbane family Family ASclepiadaceae-Milk Cycadales Family Cycadaceae-Cycad family Family weed family Family Gentianaceae-Gentian family Family Zamiaceae-Sago-palm family Division Ginkgophyta Loganiaceae-Logania family Order Lamiales Family Bor Ginkgo Class Ginkgoopsida Order Ginkgoales Family aginaceae-Borage family Family Lamiaceae-Mint family Ginkgoaceae-Ginkgo family Division Gnetophyta-Mor Family Lennoaceae-Lennoa family Family Verbenaceae mon tea and other gnetophytes Class Gnetopsida Order Verbena family Order Plantaginales Family Plantagi Ephedrales Family Ephedraceae-Mormon-tea family naceae-Plantain family Order Rubiales Family Rubi Order Gnetales Family Gnetaceae-Gnetum family Divi aceae-Madder family Order Scrophulariales Family Sion Magnoliophyta-Flowering plants Class Liliopsida Acanthaceae-Acanthus family Family Bignoniaceae Subclass Alismatidae Order Alismatales Trumpet-creeper family Family Buddlejaceae-Butterfly Family Alismataceae-Water-plantain family Family bush family Family Gesneriaceae-Gesneriad family Fam Butomaceae-Flowering Rush family Family Limnochari ily Lentibulariaceae-Bladderwort family Family US 2004/0175439 A1 Sep. 9, 2004

Myoporaceae-Myoporum family Family Oleaceae-Olive Family Cercidiphyllaceae-Katsura- family Family family Family Orobanchaceae-Broom-rape family Family Hamamelidaceae-Witch-hazel family Family Platan Pedaliaceae-Sesame family Family Scrophulariaceae aceae-Plane-tree family Order Juglandales Family Juglan Figwort family Order Solanales Family Convolvulaceae daceae-Walnut family Order Leitneriales Family Leitneri Morning-glory family Family Cuscutaceae-Dodder family aceae-Corkwood family Order Myricales Family Family Fouquieriaceae-Ocotillo family Family Hydro Myricaceae-Bayberry family Order Urticales Family Can phyllaceae-Waterleaf family Family Menyanthaceae nabaceae-Hemp family Family Cecropiaceae-Cecropia Buckbean family Family Polemoniaceae-Phlox family family Family Moraceae-Mulberry family Family Family Solanaceae-Potato family Subclass Caryophyllidae Ulmaceae-Elm family Family Urticaceae-Nettle family Order Family Achatocarpaceae-Achato Subclass Magnoliidae Order Aristolochiales Family Aris carpus family Family Aizoaceae-Fig-marigold family tolochiaceae-Birthwort family Order Illiciales Family Illi Family Amaranthaceae-Amaranth family Family Basel ciaceae-Star-anise family Family Schisandraceae laceae-Basella family Family Cactaceae-Cactus family Schisandra family Order Laurales Family Calycanthaceae Family Caryophyllaceae-Pink family Family Chenopodi Strawberry-shrub family Family Hernandiaceae aceae-Goosefoot family Family Molluginaceae-Carpet Hernandia family Family Lauraceae-Laurel family Family weed family Family -Four o'clock family Monimiaceae-Monimia family Order Magnoliales Family Family Phytolaccaceae-Pokeweed family Family Portula Annonaceae-Custard-apple family Family Canellaceae caceae-Purslane family Order Plumbaginales Family Canella family Family Magnoliaceae-Magnolia family Plumbaginaceae-Leadwort family Order Polygonales Family Myristicaceae-Nutmeg family Family Sonnerati Family -Buckwheat family Subclass Dille aceae-Sonneratia family Family Winteraceae-Wintera niidae Order Batales Family Bataceae-Saltwort family family Order Nymphaeales Family Cabombaceae-Water Order Capparales Family Brassicaceae-Mustard family shield family Family Ceratophyllaceae-Hornwort family Family Capparaceae-Caper family Family Moringaceae Family Nelumbonaceae-Lotus-lily family Family Nym Horse-radish tree family Family Resedaceae-Mignonette phaeaceae-Water-lily family Order Papaverales Family family Order Diapensiales Family Diapensiaceae-Diapen Fumariaceae-Fumitory family Family Papaveraceae sia family Order Dilleniales Family Dilleniaceae-Dillenia Poppy family Order Piperales Family Chloranthaceae family Family Paeoniaceae-Peony family Order Ebenales Chloranthus family Family Piperaceae-Pepper family Family Ebenaceae-Ebony family Family Sapotaceae Family Saururaceae-Lizard's-tail family Order Ranuncu Sapodilla family Family Styracaceae-Storax family Fam lales Family Berberidaceae-Barberry family Family ily Symplocaceae-Sweetleaf family Order Ericales Family Lardizabalaceae-Lardizabala family Family Menisper Clethraceae-Clethra family Family Cyrillaceae-Cyrilla maceae-Moonseed family Family Ranunculaceae-But family Family Empetraceae-Crowberry family Family tercup family Family Sabiaceae-Sabia family Subclass Epacridaceae-Epacris family Family Ericaceae-Heath Rosidae Order Apiales Family Apiaceae-Carrot family family Family Monotropaceae-Indian Pipe family Family Family Araliaceae-Ginseng family Order Celastrales Fam Pyrolaceae-Shinleaf family Order Lecythidales Family ily Aquifoliaceae-Holly family Family Celastraceae-Bit Lecythidaceae-Brazil-nut family Order Family terSweet family Family Corynocarpaceae-Karaka family Bombacaceae-Kapok-tree family Family Elaeocar Family Hippocrateaceae-Hippocratea family Family Icaci paceae-Elaeocarpus family Family Malvaceae-Mallow naceae-Icacina family Family Stackhousiaceae-Stack family Family Sterculiaceae-Cacao family Family Tili housia family Order Family Cornaceae-Dog aceae-Linden family Order Nepenthales Family Droser wood family Family Garryaceae-Silk Tassel family Family aceae-Sundew family Family Nepenthaceae-East Indian Nyssaceae-Sour Gum family Order Euphorbiales Family Pitcher-plant family Family Sarraceniaceae-Pitcher-plant Buxaceae-Boxwood family Family Euphorbiaceae family Order Primulales Family Myrsinaceae-Myrsine Spurge family Family Simmondsiaceae-Jojoba family family Family Primulaceae-Primrose family Family Theo Order Fabales Family Fabaceae-Pea family Order Gerani phrastaceae-Theophrasta family Order Salicales Family ales Family Balsaminaceae-Touch-me-not family Family Salicaceae-Willow family Order Theales Family Actinidi Geraniaceae-Geranium family Family Limnanthaceae aceae-Chinese Gooseberry family Family Caryocar Meadow-Foam family Family Oxalidaceae-Wood-Sorrel aceae-Souari family Family Clusiaceae-Mangosteen family Family Tropaeolaceae-Nasturtium family Order family Family Dipterocarpaceae-Meranti family Family Haloragales Family Gunneraceae-Gunnera family Family Elatinaceae-Waterwort family Family Marcgraviaceae Haloragaceae-Water Milfoil family Order Linales Family Shingle Plant family Family Ochnaceae-Ochna family Erythroxylaceae-Coca family Family Linaceae-Flax Family Theaceae-Tea family Order Violales Family Bego family Order Myrtales Family Combretaceae-Indian niaceae-Begonia family Family -Lipstick-tree Almond family Family Lythraceae-Loosestrife family family Family Caricaceae-Papaya family Family Cista Family Melastomataceae-Melastome familyFamily ceae-Rock-rose family Family Cucurbitaceae-Cucumber Myrtaceae-Myrtle family Family Onagraceae-Evening family Family Datiscaceae-Datisca family Family Fla Primrose family Family Punicaceae-Pomegranate family courtiaceae-Flacourtia family Family Frankeniaceae Family Thymelaeaceae-Mezereum family Family Tra Frankenia family Family -Loasa family Family paceae-Water Chestnut family Order Podostemales Family Passifloraceae-Passion- family Family Tamari Podostemaceae-River-weed family Order Polygalales caceae-Tamarix family Family Turneraceae-Tumera Family Krameriaceae-Krameria family Family Malpighi family Family Violaceae-Violet family Subclass Hama aceae-Barbados Cherry family Family Polygalaceae melidae Order Casuarinales Family Casuarinaceae-She MiLlwort family Order Proteales Family Proteaceae-Pro oak family Order Fagales Family Betulaceae-Birch family tea family Order Rafflesiales Family Rafflesiaceae Family Fagaceae-Beech family Order Hamamelidales Rafflesia family Order Rhamnales Family Elaeagnaceae US 2004/0175439 A1 Sep. 9, 2004

Oleaster family Family Rhamnaceae-Buckthom family Crataegus praegophyrum, Larix dedidua, Tuja Orientalis Family Vitaceae-Grape family Order Rhizophorales Fam "eligantissima', Tula Ocidentalis “columbia', XeupreSSOcy ily Rhizophoraceae-Red Mangrove family Order paris deylandii, Pseudotsuga menzisia, Abies firma, Fau Family Brunelliaceae-Brunellia family Family Chrysobal tenousus qualiqualia, Alium Cernum (wild), Juniperus "blue anaceae-Cocoa-plum family Family Connaraceae-Can pacific', Taraxacum Officinalis, Juca sp., Ilex agnifolium, narus family Family Crassulaceae-Stonecrop family Fam Tsuga Canadensis “penola, Ilex cornuta, Taxus hiksii, Taxus ily CroSSOSomataceae-CrOSSOSoma family Family media, MetaSequoia glyptotrobioldes, Pinus bungiana, Cunoniaceae-Cunonia family Family GroSSulariaceae Boxus Sempervirens, Stevartia Coreana, Prunus xOcane, Currant family Family Hydrangeaceae-Hydrangea family Betula daurica, Plantago minor; Acer palmatum “bur Family Pittosporaceae-Pittosporum family Family gundy, Acer campestre, CotynuS COgygria, Quercus robur -Rose family Family Saxifragaceae-Saxifrage “fastigiata', Acer truncatum, Archirantus bidentata, Alum family Family Surianaceae-Suriana family Order Santala japonica, Carum capsicum, AgaStache mexuicana, Prunella les Family Balanophoraceae-Balanophora family Family vulgaris, Tagetes minuta, Nepeta cataria, Ratibiunda col Eremolepidaceae-Catkin-mistletoe family Family Loran umnus-Fera, Aster-Nova anglicae, Mirica certifera, Pit thaceae-Showy Mistletoe family Family Olacaceae-Olax tisporum tibica, Taxodium dixticum (HO), Taxodium dixti family Family Santalaceae-Sandalwood family Family cum (Acetic acid), Plantago major, Scotch pine, ASOrum Viscaceae-Christmas Mistletoe family Order Sapindales canadensis, Pieras japonica, Pinus Sirtrobus, Trifolium Family Aceraceae-Maple family Family Anacardiaceae pratense, Prunus Serotica, Darura Stramonium, Geranium Sumac family Family Burseraceae-Frankincense family maculata, HydrocOtile asiatica, AStragulus Sinicus, Centau Family Hippocastanaceae-Horse-chestnut family Family ria maculata, RuSchia indurata, Myrthus comunis, Platanus Meliaceae-Mahogany family Family Rutaceae-Rue fam acidentalis, Liclum barbatum, Lavandula Oficinalis, ily Family Sapindaceae-Soapberry family Family Sima Gravilea robusta, Hyppoach rhamnoides, Filipendula roubaceae-Quassia family Family Staphyleaceae-Blad ulmaria, Betula pendula, Polygonium Odoratum, Brugmansi demut family Family Zygophyllaceae-Creosote-bush graveolens (ralf), Rhus toxicodenta, Armoraica ristica, family. Ficus benjaminii, Sluffera sp., Pelagonium zonale, Allium 0.058. In one embodiment, potential plants comprise: sp., A.Simina triloba, Lippa dulcis, Epilobium augustifolium, Atropa Belladonna, Erythrinia glabeliferus, Ipomea tricolor, Brugmansia Suaveolens (old), Brugmansia Suaveolens Erythrinia crista, Celosia cristata, Gallium sporiurn, Laurus (young), Xanthosoma Sagittifolium (), Xanthosoma Sag nobilis, Vitis labrissa, Gratiola officinalis, Symphitium off ittifolium (stem), Monstera deliciosa, Aglaonema commuta cinalis, Hosta fortuna, Casia hebecarpa, Thalictum flavum, tus, Diefenbachia leopoldii, Anthurium andreanum, Syngo Scutellarian altissima, Portulaca oleacea, Scutellaria certi niurn podophyllum, Dracaena fragranS, Ananas COmoSuS, cola, Physalis creticola, Geum fanieri, Gentiana tibetica, Strelitzia regiinae, Diefenbachia Segiunae, SyngOnium Linium hirsutum, Aconitum napellus, Podophyllum amodii aurutum, Dracaena sp., Hhaemanthus katharina, Anthurium Thymus cretaceus, Hosta fortunaea, Carlina acaulis, altersianum, Spathiphyllum grandiflorum, Spathiphyllum Chamaechrista fasciculata, Pinus pinea, Pegamun hamalis, cochlearispatum, Monstera pertusa, Anthurium magnificum, Tamarindus india, Carica papaya, Cistus incanus, Capparis Anthurium hookeri, Anthurium elegans, Calathea zebrina, Spinosa inernis, CupreSS lusitanica, Diopiros kaka, Yucca elephantipes, Bromelia balansae, Musa textilis Erungium campestre, Aesculus Woerlitzenis, Aesculus hip (Leaf), Musa textilis (Stem), Myrtius communis, Olea pocastianum, CupreSSuS Sempervirens, Celtis occidentalis, Olcaster, Olea europaea, Verium Oleander, COcculus lauri Polygonum cuspidatum, Eleagnus angustifolia, Eleagnus folius, MicroSOrium punctatum, Ficus sp., Senseviera sp., cemutata, Gentiana macrophilla, Brassica napa, Sesbania Adansonia digitata, Boechimeria boloba, Piper nigrum, exaltata, Sesbania Speciosa, Spartina potentiflora, Brassica Phymatosorus Scolopendria, Turnera ulrnifolia, Nicodemia juncea, Helianthus annus, Puansetia sp., PelargOniurn ZOn diversifolia, Tapeinochilos spectabilis, Rauwolfia tetra ale, Sundapsis spp., Leontopodium alpinum, Lupinus phylla, Ficus elastica, Cycas Cirinalis, Caryota ureus, Cyn luteaus, Buxus microphilla "japonica, Liatris Spinata, namonum zeylonicum, Aechmea luddemoniana, Foenix zeu Rimula japonica, Betula nigra, Filipendula vulgrais, Lobe lonica, Ficus benjamina, Ficus purnila, Murraya exotica, lia Siphitica, Gravilia robusta, Reseda luteola, Gentiana Trevesia Sungaica, Clerodendrum SpecioSSicum, Actinidi littorala, Campanula carpatica, AeSculus hypoca Stanum, colonicta, Paeonia lactiflora, Paeonia Suffructicisa, Quer AeSculus waertilensis, Ageratum conizoides, Psidium gua cus imbricaria, Iris alida, Portulaca Olleracea, Poligonum java, Ailantus altissima, Buxus microphylla "japonica', aviculare, Iris pseudocarpus, Allium nutans, Allium fistulo HydrocOtile asiatica, Gravilea robusta, Brugmansia SuaveO Sum, Antericum ramOSum, Veratrum nigrum, Poligomun lens, Thymus pulliglodes, Thymus lemabarona, Thymus Ser latifolia, Hosta lancefolia, Hosta zibalda, Echinops Sphae, phylum (wild), Gaultheria procumbens, Thymus Serphylum, Paeonia daurica, Inula hilenium, Trambe pontica, Digitalis Thymus camosus, Thymus thrasicus, Caicatus floridus, Zin lutea, Bactisia australis, AuStolachia australis, His SopuS giber Oficinalis, Lapia dulcis, Thymus vulgaris "argen zeraucharicus, Feucrium hamedris, Sedum album, Heracle teus', Thymus praecox "arcticus', Thymus pulleglodes lum pubescens, Origanum vulgare, Cachris alpina, Haser "lemons', Thymus speciosa, Thymus camosus, Thymus trilobum, text missing or illegible when pseudolamginosus, Thymus praecox, Thymus vulgaris filed Anemona japonica, Clematis rectae, Talictrum sp., Alchemilla sp., Potentilla alba, Poterium Sangiusorba, "Oregano”, Ficus religiosa, ForSithsia Suspensa, Chelido Minispermum dauricum, Oxobachus nictogenea, Armora nium majus, Thymus wooly, Thymus portugalense, Nicoti cea rusticana, Cramble cardifolia, Agrimonia eupatora, ana tabacum, Thymus cytridorus "aureus', Thymus vul USchusa sp., Polymonium ceruleum, Valeriana Oficinalis, garis, Cactus Oficinalis, Lal lab purpurea, Juglands regia, Pulmonaria molissima, Stachis lanata, Coronolla varia, Actinidia chinensis, Hemerocalis spp., Betula pendula, Gar Platicada grandiflora, Lavandula Oficinalis, Vincetoesicum denia jasminoides, Taxodium dixticum, Magnolia loebheril, Oficinalis, Acolypha hispida, Gnetum guemon, Psychotria US 2004/0175439 A1 Sep. 9, 2004

nigropunctata, Psychotria metbacteriodomaSica, Cobiaeum huminstratus, Krameria parvifolia, Parkinsonia aculeata, variarturn, Phyllanthus grandifolium, Pterigota alata, Calliendia eriophylla, Lupinus arizonicus, Olyneya teSOta, Pachyra afinis, Sterulia elata, Phylidendron speciosus, AStragalus lentiginosus, PSOrOthamunuS SpinOSuS and Lupi Pithecelobium unguis, Sanchezia nobilis, Oreopanax capi tata, Ficus triangularis, Pigelia pennata, Piper Chaba, Lau nus sparsiflorus; members of the loasa family, Loasaceae, rus nobilis, Erythrinia cafra, MetroSideros excelsa, Osman including involucrata, M. pumila and Mohavea thus spp., CupreSSuS Sempervirens, Jacobinia sp., Senecio Confertiflora; members of the cactus, Cactaceae, family, platifilla, LivistOna fragranS, Tetraclinis articulata hinensis, Such as Camegiea gigantia, Opuntia leptocaulis, FerocactuS Eucaliptus rudis, Podocarpus Spinulosus, EriobOtria wisiizenii, O. bigelovii, O. pheacantha, O. versicolor, O. japonica, Gingko biloba, Rhododendron spp., Thuja Occi fulgida, Echinocereus engelmannii, Mammillaria micro dentalis, Fagopyrum Suffruticosum, Geum macrophyllum, carpa, O. basilaris, Stenocereins thurberi, O. violacea, M. Magnolia cobus, Vinca minor, Convalaria majalis, Corylus tetrancistra, O. ramOSissima, O. acanthocarpa, E. pectin avelana, Barbaric sp., ROSa multiflora, Ostrea carpinifolia, atins and O. arbuscula; members of the evening primrose, Ostrea connote, Quercus rubra, Tulip tree, Sorbus aucu paria, Betula nigra (leaf), Betula nigra (flower), CaStanea Onagraceae, family, Such as Oenothera deltoides, Camis.SO Sativa, Bergenia crassifolia, Artemisia dracunculus, Ruta nia claviformis and Oe. primiveris; members of the milk graveOlens, Quercus nigra, Schisandra Chinensis, Betula weed, ASclepiadaceae, family, including ASclepias erosa, A. alba, Sambucus niora, Gentiana cruciata, Encephalaris Sublata and SarcoStemma cynanchoides; members of the horridum, Phebodium aureum, Microlepia plaiphylla, Cera borage, Boraginaceae, family, Such as Cryptantha augusti toramia mexicana, StepOchlaena tenuifolia, Adianthum tra folia and Amsinckia intermedia; members of the Sunflower, pezieformis, Adianthum radiatum, Lycodiumjaponicum, Compositae, family, including Baccharis Sarothroides, AeSSopteria crasifolia, Asplenium australasicum, Agatis Monoptilon belloides, Erieron divergens, acerosa, robusta, Osmunda regalis, OsmundaStrum claytonionum, Melampodium leucanthan, Chaenactis fremontii, CalycOS Phyllitis Scolopendrium, Polyschium braunii, Crytomium eris wrightii, Malacothrix californica, Helianthus annus, H. fortunei, Dryopteris filis-max, Equisetum variegatum, niveus, Geraea canescens, Hymenothrix wisiizenii, Encelia Anthyrium nopponicum, Anthyrium filis-femina, Partheno text missing or illegible when filed californica, SicuS tricuspidata, LiguStum vulgare, Charnaeciparis Machaeranthera tephrodes, Xylorhiza tortifolia, Cirsinn pisifera, Rosa COcanica, Citinis Coggriaria, Pinus Strobus, neomexicanum, Antennaria parviflora and Ch. douglasii; Celtis Occidentalis, Picea Schrenkiana, Cydonia Oblonga, members of the caltrop, Zygophyllaceae, family, including Ulmus punriila, EuOnomus verrucosa, Deutria Scabra, Larrea tridentata and Kallstroemia grandiflora; members of Mespilus germanica, Quercus caStanufolia, EuOnOmuS the mallow, Malvaceae, family, including Hibiscus coulteri, europea, Seruginea Suffruticisa, Keyleiteria paniculata, H. denudatus and Sphaeralcea ambigua, members of the Seringa josiceae, Zelcova, carpinifolia, Abies cephalonica, phlox, Polemoniaceae, family, Such as Luanthus aureus; Taccus bacata, Taxus cuspidata, Salis babilonics, Thuja members of the unicom plant, Martyniaceae, family, Such as Occidentalis, Actinidia Colomicta, Magonia agrifolia, Aralis Proboscidiea altheaefolia; members of the gourd, Cucurbi mandshurica, Luglands nigra, EuOnimus elata, Princepia taceae, family, Such as Cucurbita digitata; members of the sp., ForSitsia europea, Sorbocotoneaster sp., Morus alba, lily, Lilaceae, family, including kennedyi, Dich Crategus macrophyllum, Eucomia ulurifolia, Sorbus comin eloStemma pulchellum, Allium macropetalum and Hespero icta, Philodendron amurense, Comus mass, Korria callis indulata; members of the Ocotillo, Fouquieriaceae, japonica, Parrotia persica, Jasminum frutocarus, Sulda family, including Fouquieria Splendens; members of the Sanganea, Pentaphylloides fruticOSa, Sibirea altaiensis, figwort, Scrophulariaceae, family, Such as Castilleja sp., CeraSuS japonica, Kolkwitzia amabilis, Amigalalu.S. nana, PenstemOn parryi and Orthocarpus purpuraScens; members Acer mandshurica, Salix tamarisifolia, Amelanchier Spi of the acanthus, Acanthaceae, family, including Anisacan cata, CeraSuS maghabab, Prunus cerasifera, Corvillus ave thus thurberi, Justicia califonica and Ruellia nudiflora; lana, Acer tataricum, Viburnum opulus, Siringa vulgaris, members of the four o'clock, Nyctaginaceae, family, Such as Fraxinus exelsior, Quercus trojana, Chaemomelis Superba, Allionia incarnata, villosa and Mirabilis multiflora; Pinus Salinifolia, Berberis vulgaris, Cotoneaster horisonta members of the geranium, Geraniaceae, family, including lis, Cotoneaster fangianus, Fagus Silvatica, Pinus pumila, Erodium cicutarium; members of the waterleaf, Hydrophyl Pinus SilveStris and Berberis thungergi. laceae, family, Such as Nama demissium, Phacelia bomby 0059 Another interesting group of plants that can be cina and Ph. distans, members of the bignonia, Bignoni considered as plants and/or potential plants of the invention aceae, family, Such as Chilopsis linearis, members of the comprise the plants that are indigenous to arid regions, for Vervain, Verbenaceae, family, including Glandularia good dugii and Verbena neomexicana; members of the mint, example, those located between 35 north latitude and 35 Labiatae, family, Such as Hyptis emoryi and Salvia colum South latitude. In accordance with the present invention bariae; members of the broomrape, Orobanchaceae, family, potential extracts and extracts of the invention can be Such as Orobanche cooperi; members of the portulaca, obtained from from plants Selected from the group compris Portulaceae, family, Such as Talinum auriantiacum; mem ing: the agave, Agavaceae, family including Such members bers of the carpet-weed, Aizoaceae, family, Such as SeSu as: Yucca elata, Y, breviflora, Agave deserti, A. chrysantha, vium verrucosum, members of the flax, Linaceae, family, Dasylirion wheeleri; the buckwheat, Polygonaceae, family, Such as Linum lewisii; members of the potato, Solanaceae, Such as Eriogonum fasciculatum; the crowfoot, Ranuncu family, including Nicotiana trigonophylla and Physalis laceae, family, Such as Delphinium Scaposum, Anemone lobata, and members of the cochlospermum, Cochlosper tuberOSa and D. parishii; the poppy, Papaveraceae, family, maceae, family, Such as palmatifida. including PlatystemOn Caifomicus, Argemone pleiacantha, 0060 Pre-Harvest Treatment Corydalis aurea, Eschschoizia californica and Ar. corym bOSa; members of the mustard, Cruciferae, family, Such as 0061. Once a potential plant is selected, a pre-harvest Dithyrea Californica, Sireptanthus carinatus and Lesquer treatment is Selected, wherein the treatment can be water or ella gordoni; members of the legume, Leguminosae, family, water in combination with a stressor, elicitor, or inducor. Such as Acacia greggii, PrOSopis velutina, A. COnStrica, One skilled in the art would appreciate to perform the Senna covesii, Cercidium floridum, C. microphyllum, Lotus procedure with water and then with a Series of Stressors in US 2004/0175439 A1 Sep. 9, 2004

order to determine whether the potential plant becomes an production or enhanced production of one or more extra extract of the invention which demonstrates inhibitory activ cellular proteases. One skilled in the art would be able to ity against one or more extracellular proteases. determine from the results of the assay against the panel of 0.062. In one embodiment this invention relates to altering extracellular proteases whether it is desirable to follow one the amount and/or composition of extracellular protease or more of the StreSSor regiemes. inhibitory activity by Stressing a plant by chemical elicitors 0069 Harvesting the Plant Material for Extraction and which act as Stressor agent and activated defence plants Optional Storage Treatment pathways as mechanical wounding, drought, heat, or cold before tissue collection and extraction. 0070 The plant material may be used immediately after pre-harvest treatment, or it may be desirable to Store the 0.063. In one embodiment, stress involves exposing plants plant material for a period of time, prior to performing the to a Solution of one or more chemical elicitors to induce extraction procedure(s). In one embodiment, the plant mate defense metabolic pathways and Secondary metabolites rial could be treated prior to Storage. In Such cases, the prior to collection of plant tissues. Known chemical elicitors treatment could include drying, freezing, lyophilisizing, or reported in the literature include OZone, hydrogen peroxide, Some combination thereof. jasmonic acid and its derivatives, arachidonic acid, Salicylic acid and ester derivatives, alpha-and gamma-linoleic 0071. Following treatment to prepare the plant material acids, Volicitin, peptides, oligopeptides, Saccharides, oli for Storage, the plant material may be Stored for an extended gosaccharides Such as chitosan, and Synthetic chemicals period of time, prior to contacting the plant material with the Such as BenZO-1,2,3-thiadiazole-7-carbathioic acid S-me first Solvent. In one embodiment the plant material is Stored less than one week. In one embodiment the plant material is thyl ester (BTH). Stored from one week to one month. In one embodiment the 0064. A stressor may be one or more organic compounds. plant material is Stored from one month to Six months. In one Some exemplary compounds that may be used as a stressor embodiment the plant material is stored from four months to include Jasmonic acid, Jamonic acid lower alkyl esters, one year. In one embodiment the plant material is Stored O-linoleic acid, C-linoleic acid lower alkyl esters, Y-linoleic longer than one year. acid, Y-linoleic acid lower alkyl esters, Arachidonic acid, Arachidonic acid lower alkyl esters, Salicylic acid. 0072 The Extraction Process 0065. A stressor may be able to induce abiotic stresses in 0073. As depicted in FIG. 1, there are generally three plants. Thus, for example, plants can be treated with one or basic extraction processes which can be performed in more chemical or mechanical Stresses prior to tissue collec Sequence to generate potential pre-extracts. The procedure tion. Mechanical StreSS can be performed twelve hours to ten for each Extraction process entails contacting the Solid plant days prior to tissue collection. In one embodiment, mechani material with a Solvent with adequate mixing and for an cal StreSS can be performed one day to three days prior to amount of time to ensure adequate exposure of the Solid tissue collection. In one embodiment, mechanical StreSS can material to the solvent to enable inhibitory activity to be be performed three to Six days prior to tissue collection. In taken up by the solvent. Solvent A, B and C generally one embodiment, mechanical StreSS can be performed four to represent Separate classes of Solvents, for example, aqueous, eight days prior to tissue collection. In one embodiment, alcoholic and organic. They are generally applied in a polar mechanical StreSS can be performed six to ten days prior to to non-polar order. They can be applied in a non-polar to tissue collection. polar order, however, in each case the Solid matter must be dried prior to contacting the Solid matter with the Subsequent 0.066 Chemical stress can be induced by spraying plant solvent. The liquid is then separated from the solid material once or more than once with an aqueous or alco (insoluble) matter by a process known to those skilled in the holic solution of the chemical elicitor one hour to 10 days art, to generate two fractions: the liquid fraction which is a prior to tissue collection. In one embodiment, chemical potential pre-extract and a Solid fraction. StreSS can be induced one day to three days prior to har vesting the plant tissue; in one embodiment, chemical StreSS 0074 The term “liquid” is used to denote a distinction can be induced two to four days prior to harvesting the plant from the Solid, insoluble matter. Thus, a liquid, which may tissue; in one embodiment, chemical StreSS can be induced be converted to a gas or function in a gaseous form, as in the five to ten days prior to harvesting the plant tissue. case with Steam, for example can Serve as a Solvent. Like wise, other non-Solid Solvents may be used Such as highly 0067. A chemical stress can be added by feeding a plant Viscous liquids or other gaseous Solvents, Some of which can with an aqueous or alcoholic Solution of the chemical. then be converted into a liquid phase. Likewise, the plants can be stressed by airborne transport of the chemical agents one hour to ten days prior tissue 0075 Aliquid solvent may also indicate a composition or collection. In one embodiment, plants can be treated by a mixture of Solvents. Common examples include a buffered Spray one day before collection. In one embodiment, Such acqueous solution, such as a TRIS-HCl buffer, or an ethanol/ chemical StreSS can be induced one hour to three days prior methanol combination. to harvesting the plant tissue, in one embodiment, Such 0076. In one embodiment, selected parts of a plant chemical StreSS can be induced two to eight days prior to (which can be fresh, dried or frozen) can be crushed either harvesting the plant tissue; in one embodiment, Such chemi mechanically, using a grinder or any device to break plant cal StreSS can be induced five to ten days prior to harvesting parts into Small particles, or by freezing them in liquid the plant tissue. nitrogen. In another embodiment, plant particles can be 0068 Any combination of the above-mentioned stressors extracted with an aqueous TRIS-HCl buffer at pH 6-8, in one and treatment regiemes can be employed to induce the embodiment pH 7, from 30 minutes to 8 hours, in one US 2004/0175439 A1 Sep. 9, 2004

embodiment 30 min to 2 hours, at a temperature between 4 would appreciate that there are numerous methods and to 50 C., in one embodiment 4 to 25 C.; in one embodi techniques for measuring Such activity, that can be used to ment, 4-10 C. In one embodiment, extraction can be determine, for example, which extracts are of interest and to performed at 4 C. for 30 minutes. follow the processing of the active ingredient(s) giving rise 0077. The solid material can be separated from the sol to Such activity. vent by centrifugation, filtration or any other means known 0084 Currently, there are several assays to measure to those of Skill in the art to Separate Solids from a Solution, MMP, elastase andcathepsins activity (for a review of these to yield aqueous, alcoholic or organic extract, a potential methods, see Murphy and Crabbe, In Barrett (ed.) Methods pre-extract. These potential pre-extracts can can be tested in Enzymology. Proteolytic Enzymes. Aspartic Acid and directly by a panel of extracellular proteases for the ability Metallopeptidases (New York: Academic Press, 1995)-248: to inhibit extracellular protease activity, and/or Subjected to 470. One method, the gelatinolytic assay, is based on the further Separation procedures to generate a potential extract degradation of radio-labelled type I collagen. Although this as described below. method is relatively Sensitive, it requires the use of radio 0078. The remaining solid can be contacted with a second labelled Specific Substrates. Solvent, Such as an alcoholic Solvent and a coSolvent, 0085 Another widely-used technique is the zymography methanol or water In one embodiment, ethanol is used as assay. In this assay, MMP, elastase and cathepsins activity is alcoholic Solvent, wherein the range of ethanol:methanol, detected by the presence of negatively-stained bands fol ranges from 50:50 to 85:15, and 10 minute to one hour, in lowing electrophoresis in Substrate-impregnated SDS poly one embodiment 15 to 30 minute extraction time, at a acrylamide gels. The Zymography assay is a Sensitive and temperature range of 4 to 25 C. in one embodiment, 4 to 10 quantitative method for the detection of various MMPs, C. in one embodiment, and 4 C. in another embodiment. elastase, cathepsins and TACE in biological Samples, none Adequate contact of the Solvent with the plant material can theless, it is labour intensive and has a low dynamic range. be encouraged by Shaking the Solid Suspension for 15 minto Zymography, moreover, is not Suitable to measure the intrin 24 hour at a temperature ranging from 4 to 50° C. sic net activity in biological Samples: SDS dissociates 0079 The alcoholic extract is recovered and separated MMP-TIMP complexes and activates latent enzyme forms. from the solids by centrifugation (the material which is This is particularly important Since matrix degradation ulti insoluble in alcohol is used for organic extraction(s)). The mately depends on the ratio of free active gelatinase to latent potential pre-extract can be dried using a lyophilizer, a Speed proenzyme or TIMP-complexed forms. vac, a rotary evaporator, or a vacuum pump and dried under 0086 A microtitreplate assay has been developed Vacuum in order to remove the Solvent. The dried extract can recently (Pacmen et al., (1996) Biochem. Pharm. 52: 105 be dissolved in Tis-HCl buffer wherin the pH is between pH 111). This assay provides measurement of net biological 6 to pH 8, in one embodiment and at pH 7 in one embodi enzymatic activity of MMP, does not require a radioisotope ment, and assayed against the panel of extracellular pro Safety environment, and could be used efficiently for routine teases for its bioactivity or, as in the case of the aqueous measurement of inhibitory activity of MMP; however, it is extract, the alcoholic extract can be treated to obtain purified not likely to be highly efficient as a diagnostic test Since the extracts, as described below. incubation times are long and the Sensitivity is much lower 0080. The organic extract can be obtained by shaking the than that obtained by Standard Zymography and radio residual solid for one to twenty-four hours in one embodi labelled Substrate assayS. ment, for one to fifteen hours in one embodiment, one to 0087. Other methods used auto-quenched flourogenic eight in one embodiment, one to four in one embodiment, Substrates. Many flourogenic Substrates have been designed with an organic Solvent Such as diethylether, hexane, dichlo for the quantification of MMPs, elastase, and cathepsins romethane, or ethylacetate. The Solid can be separated by activity throught fluorescent level variation meSuring centrifugation or by filtration (regular or Suction) and the (reviewed by Nagase and Fields (1996) Biopolymers 40: organic Solvent removed by distillation or by using a rotating 399-416), evaporator. The organic extract can be dissolved in an aqueous buffer, or a mixture of an aqueous buffer and a 0088 Fluorescence polarization assays were based on the Suitable Solvent (Such as dimethylsulfoxide), to evaluate its principle that when fluorescent molecules are excited with bioactivity. In one embodiment the organic extracts are plane polarized light, they will emit light in the same prepared using dichloromethane as the Solvent of extraction, polarized plane provided that the molecule remains Station and the extraction is performed at room temperature for 2 ary throughout the excited State. However, if the excited hours. molecule rotates or tumbles during the excited State, then light is emitted in a plane different from the excitation plane. 0.081 Are included in the invention extracts prepared by If Vertically polarized light is used to excite the fluorophore, all known large, medium and Small-scale methods to prepare the emission light intensity can be monitored in both the eXtractS. original vertical plane and also the horizontal plane. The degree to which the emission intensity moves from the 0082) Determination of Extracellular Protease Inhibitory vertical to horizontal plane is related to the mobility of the Activity in an Extract fluorescently labeled molecule. If fluorescently labeled mol 0.083. In order to prepare various embodiments of the ecules are very large, they move very little during the excited invention, (i.e., extracts, compositions and formulations State interval, and the emitted light remains highly polarized with extracellular protease inhibitory activity) one requires with respect to the excitation plane. If fluorescently labeled techniques for measuring qualitatively and/or quantitatively molecules are Small, they rotate or tumble faster, and the the presence of such inhibitory activity. One skilled in the art resulting emitted light is depolarized relative to the excita US 2004/0175439 A1 Sep. 9, 2004

tion plane. Therefore, FP can be used to follow any bio 0096 Liquid-liquid extraction means include the use of chemical reaction which results in a change in molecular any mixture of Solvents known from those in the art, size of a fluorescently labeled molecule (e.g. protein-DNA including Solvents under Supercritical conditions. Typical interactions, immunoassays, receptor-ligand interactions, Solvents include, but are not limited to, hydrocarbon, chlo degradation reactions). (Adapted from Bolger R, Checovich rinated Solvents, organic esters, organic ethers, alcohols, W. (1994) Biotechniques 17(3):585-9.). water, and all possible aqueous Solutions. The liquid-liquid extraction can be effected manually, Semi-automated or 0089 Another method uses the fluorescent activated Sub completely automated, and the Solvent can be removed or strate conversion (FASC) assay described in Canadian concentrated by any usual techniques known from those in Patent No. 2,189,486 (1996) and in St-Pierre et al., (1996) the art (S. Ahuja, Handbook of BioSeparations, Academic Cytometry 25:374-380. Press, 2000). 0090 The Commercial Process for Preparing Extracts of 0097 Solid-phase extraction (SPE) means include tech the Invention niques using cartridges, columns or any other devices used 0.091 Extracts of the invention can be prepared on a in this technique and known in the art. The Sorbents that may commercial Scale by repeating the extraction process that be used with this method include but are not limited to silica results in an optimal composition of extracts demonstrating gel (normal phase), reverse phase Silica gel (modified silica an inhibitory activity of interest. As demonstrated in FIG. 3, gel), ion-exchange resins, and fluorisil. The invention also one would simply Scale-up the procedure and include Steps includes the use of Scavenger resins or any others trapping of quality control to ensure reproducible results for the reagents attached to Solid Supports derived from organic or resulting extracts. inorganic macromolecular materials to remove Selectively active ingredients or any constituents from Said extracts. 0092 Methods of Purifying or Fractionating Active Ingredients from Plant Extracts 0098 Membrane, reverse osmosis and ultrafiltration means include the use of all types of membranes known 0093. There are a number of techniques well known in from those in the art, as well as the use of preSSure, vacuum, the art for isolating protease inhibitors from natural Sources centrifugal force, and/or any other means that can be utilized For example, For example, purifications can be performed in membrane and ultrafiltration processes (S. Ahuja, Hand using centrifugation, ultracentrifugation, filtration, liquid or book of Bioseparations, Academic Press, 2000). gas phase chromatography (including size exclusion, affin ity, etc.) with or without high pressure, lyophylisation, 0099 Dialysis means includemembranes having molecu evaporation, precipitation with various “carriers” (PVPP, lar weight cut-offs varying from less than 0.5 KDa to larger carbon, antibody, etc.), or any combination thereof. One than 50 KDa. The invention also covers the recovery of skilled in the art, would appreciate how to use the following purified and/or fractionated extracts from either the dialysate options, in a Sequential fashion, in order to enrich each or the retentate by any means known in the art including but Successive fraction in the activity of interest by following its not limited to evaporation, reduced pressure evaporation, activity throughout the purification procedure, using one of distillation, Vacuum distillation, and lyophilization. the assays for the inhibitory activity against an extracellular 0100 Chromatographic means include all means of car protease of interest, as defined above. rying out chromatography known by those skilled in the art 0094. The present invention also includes compounds, and described in G. Sofer, L. Hagel, Handbook of Process chemicals, active principles, and purified or concentrated Chromatography, Academic Press, 1997 . Fractionation, extracts that could be obtained by purification, partial puri partial purification, and/or purification can be carried out by fication, and/or fractionation of plant extracts that are Subject but not limited to regular column chromatography, flash of the invention. Purification, partial purification, and/or chromatography, high performance liquid chromatography fractionation can be achieved by any methods known by (HPLC), medium pressure liquid chromatography (MPLC), those skilled in the art. These methods include, but are not Supercritical fluid chromatography (SFC), countercurrent limited to: Solid-liquid extraction, liquid-liquid extraction, chromatography (CCC), moving bed chromatography, Simu solid-phase extraction (SPE), membrane and ultrafiltration, lated moving bed chromatography, expanded bed chroma dialysis, chromatography, Selective precipitation, electro tography, and planar chromatography. With every chromato phoresis, and Solvent concentration. graphic methods, Sorbents that may be used include but is not limited to Silica gel, alumina, fluorisil, cellulose and 0.095 Solid-liquid extraction means include the use of all modified celluloses, all possible modified Silica gels, all possible Solvents known from those in the art, and covers the types of ion-exchange resins, all types of size exclusion gels use of Supercritical Solvents, SOXhlet eXtractors, Vortex and any other sorbents known from those skilled in the art Shaker, ultrasounds and any other means to enhance extrac and described in T. Hanai, HPLC: A Practical Guide, RSC tion, as well as recovery by filtration, centrifugation and any Press, UK 1999. The present invention also includes the use related methods as described in the literature (R. J. P. of two or more Solvent gradients to effect the fractionation, Cannell, Natural Products Isolation, Humana Press, 1998). partial purification, and/or purification of Said active extracts The Solvent is Selected from the group consisting of, but not in any chromatographic methods. The Solvents that may be limited to, hydrocarbon, chlorinated Solvents, organic esters, utilized include but are not limited to hexanes, pentane, organic ethers, alcohols, water, and mixtures thereof. In the petroleum ethers, cyclohexane, heptane, diethyl ether, case of Supercritical fluid extraction, the invention also methanol, ethanol, isopropanol, propanol, butanol, isobu covers the use of modifiers as described in V. H. Bright, M. tanol, tert-butanol, water, dichloromethane, dichloroethane, Eé Pé McNally, Supercritical Fluid Technology, ACS Symp. ethyl acetate, tetrahydrofurane, dioxane, tert-butyl methyl Ser. Vol. 488, ch. 22, 1999. ether, acetone, and 2-butanone. When water or and aqueous US 2004/0175439 A1 Sep. 9, 2004 phase is used, it may contains certain amounts of iorganic or evaporation, distillation (normal and reduced pressure), cen organic Salts and the pH may be adjusted to different values trifugal vacuum evaporation (speed-vac), and lyophilizatiorl with an acid or a base to enhance fractionation and/or purification. 0109 To get a better understanding of the invention described herein, the following examples are Set forth. It 0101. In the case of planar chromatography, the present should be understood that these examples are for illustrative invention includes the use of all variants of this type of purposes only. Therefore, they should not limit the Scope of chromatography including but not limited to one- and two this invention in any way. dimension thin-layer chromatography (1D- and 2D-TLC), high performance thin-layer chromatography (HPLC), and EXAMPLES centrifugal thin-layer chromatography (centrifugal TLC). Example I 0102) In the case of countercurrent chromatography (CCC), the present invention includes the use of manual, 0110 Preparation of Stressed and Non-Stressed Plant Semi-automated, and automated Systems, and the use of all Extracts Pre-Harvest Treatment Aerian parts of a living plant possible Solvents and Solvent combinations necessary to are sprayed with an aqueous Solution of gamma linolenic effect fractionation and/or purification of Said active extracts acid (6,9,12-Octadecatrienoic acid, Sigma L-2378) (stress as described in W. D. Conway, R. J. Petroski, Modern G) or arachidonic acid (5,8,11,14-Eicosatetraenoic acid, Countercurrent Chromatography, ACS Symp. Ser. Vol. 593, Sigma A-3925) (stress A) (400 uM in water with 0.125% 1995. Solvent removal and/or concentration can be effected (v/v) Triton X-100) to completely cover the . by any means known by those skilled in the art, including but not limited to reduced pressure evaporation, evaporation, 0111 Harvest Solid S1 and Optional Storage Treatment reduced pressure distillation, distillation, and lyophilization. 0112 Twenty to twenty-four hours after the stress, more than 4 grams of leaves, Stems, , flowers, Seeds or other 0103) The present invention includes the fractionation, plant parts are harvested and frozen immediately in dry ice, partial purification, and purification of Said active plant then transferred as soon as possible to a -20°C. freezer until extracts by expanded bed chromatography, moving and use. Plant materials may be stored at -20° C. for a long Simulated moving bed chromatography, and any other period of time, more than a year, without losing inhibitory related methods known by those skilled in the art and described in G. Sofer, L. Hagel, Handbook of Process activity. Temperature is monitored to ensure a constant Chromatography, Academic Press, 1997 and S. Ahuja, condition. Handbook of Bioseparations, Academic Press, 2000. 0113 Stressed and non-stressed plant specimens are col lected as wet samples and stored at -20° C. for various 0104 Selective precipitation means includes the use of periods of time, and are Submitted to a process which all possible Solvents and Solvent combinations, the use of generats 3 Subfractions: aqueous, ethanolic and organic temperature changes, the addition of precipitent and/or fractions. Complete extraction process are performed in a modifiers, and/or modifying the pH by adding a base or an continuous cycle using the following Steps. An initial 5 g of acid to effect a Selective precipitation of active principles or plant Specimen is homogenized in liquid nitrogen with a any other constituents. blender. The resulting powder is weighed. 0105. Further, the present invention covers the fraction 0114 Extraction Process I: Aqueous Extraction ation, partial purification, and purification of Said active plant extracts by electrophoresis and other related tech 0115) To each 4.5 grams of plant powder, 12 ml of a cold niques known tothose skilled in the art. solution of 100 mM Tris, pH 7.0 is added. The mixture is thoroughly Vortexed for 2 minutes. The mixture is kept on 0106 The invention also includes the fractionation, par ice for 30 minutes and vortexed after each 10 minute period tial purification, and/or purification of Said active plant of time. The sample is centrifuged in a CorexTM 30 ml tube extracts by Steam distillation, hydrodistillation, or any other for 5 minutes at 4500 rpm. The resulting Supernatant is related methods of distillation known from those in the art decanted in a 15 ml tube after filtration with a Miracloth TM (L. M. Harwood, C.J. Moody, Experimental Organic Chem filter. This extract is therefore referred as the Potential istry, Blackwell Scientific Publications, UK, 1989). Pre-Extract A. The pellet, referred as Solid S2, is kept for 0107 The process of purifying the active component(s) ethanolic extraction. also includes the concentration of purified or partially puri 0116. The aqueous extract (Potential Pre-Extract A) is fied chemicals, active ingredients, active principles by Sol further purified in order to determine its extracellular pro vent removal of Said plant extracts and/or fractionated plant tease inhibition capability. The Potential Pre-Extract A is extracts, and/or purified plant extracts. The techniques of purified by by size-exclusion chromatography, wherein the Solvent removal are known to those skilled in the art and aqueous extract is chromatographed on a calibrated Sepha include but are not limited to rotary evaporation, distillation dex G-25 column (1x10 cm) using a 20 mM Tris-HCl, 150 (normal and reduced pressure), centrifugal vacuum evapo mM NaCl, pH 7.5 buffer as eluant. Fractions corresponding ration (speed-vac), and lyophilization. to compounds that seem to have a molecular weight (MW) 0108. One embodiment of the invention includes the less than 1500 daltons (D) are pooled to constitute the concentration of chemicals, active ingredients, active prin purified acqueous extract that is tested for inhibitory activity ciples by Solvent removal of Said plant extracts and/or in an assay as described in Example II. fractionated plant extracts, and/or purified plant extracts. 0117 Prior to this analysis, the extract is treated with The techniques of Solvent removal are known to those 10% gelatin-Sepharose (Pharmacia Biotech, Uppsala, Sw.) skilled in the art and include but are not limited to rotary in order to remove unspecific enzyme ligands. To 1 mL of US 2004/0175439 A1 Sep. 9, 2004 extract, 100 till of gelatin-Sepharose resin is added in a Example II microassay tube, the Solution in the tube is mixed, kept on ice for 30 minutes, and then centrifuged 5 minutes at 5,000 0.124. In Vitro Enzyme Inhibition Assays rpm. The Supernatant is removed and used directly for 0.125 The inhibitory activity of sample compositions asSayS. towards human MMP-1, human MMP-2, human MMP-3, 0118. Extraction Process 11 Alcholic Extraction human MMP-9, human cathepsin-B, human cathepsin-D, human cathepsin-G, human cathepsin-L, human cathepsin 0119) To the pellet, Solid S2, collected from the previous K, human leukocyte elastase (HLE), bacteria cloStripain and aqueous extraction, 12 ml of cold ethanol:methanol (85:15) bacteria Subtilisin can be determined using either fluoro is added and the mixture is thoroughly vortexed for 2 genic Substrates or the FASC assay. minutes. The mixture is kept on ice for 30 minutes and Vortexed every 10 minutes. The Sample is centrifuged in a 0126. Measurement of Human MMP-1, -2, -3 and -9 CorexTM 30 ml tube for 5 minutes at 4,500 rpm. The Activity with Fluorogenic Peptidic Substrates resulting Supernatant is decanted in a 15 ml tube after 0127 MMP-1, -2, -9 are purified from natural sources filtration with a MiraclothTM filter. The pellet, referred as (human immortalized cell lines: 8505C (Deutsche Sam Solid S3 is kept for the Subsequent organic extraction. This mlung von Mikroorganismen und Zellkulturen GmbH) for extract is therefore referred as the Potential Pre-Extract B. MMP-1, HT-1080 (ATCC, Manassas, Va.) for MMP-2 and 0120) The ethanolic extract, Potential Pre-Extract B, is THP-1 (ATCC, Manassas, Va.) for MMP-9) as described in purified by liquid/liquid extraction prior to analysis by literature and based on protocols found in L. M. Clark: enzymatic assay. For this purpose, 1 ml of ethanolic extract <>, Humana Press is evaporated under vacuum, dissolved in 150 ul of dimeth (2001). Recombinant human MMP-3 is overexpressed in E. ylsulfoxide (DMSO), and completed to a final volume of 1.5 Coli and purified according to Windsor L J, Steele D L ml with Tris buffer (final concentration: Tris-HCl 20 mM; (2001), Methods Mol Biol 151:191-205. Proteolytic activity pH 7.5). Four ml of hexane is added to the Tris phase in a of these proteases is evaluated with the assay based on the glass tube and the tube is thoroughly vortexed, then allowed cleavage of auto-quenched peptide Substrate: (MCA-Pro to form a biphasic liquid. The organic phase is removed and Leu-Glv-Leu-Dpa-Ala-Arg-NH.TFAIDpa=N-3-(2,4-dini the extract is Submitted to a Second round of liquid/liquid trophenyl)-L-2,3-diaminopropionyl) for MMP-1, -2, and extraction. The aqueous phase is removed and treated with -9; and, MCA-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys 10% gelatin-Sepharose (Pharmacia Biotech, Uppsala, Sw.) (DNP)-NH. (DNP=2,4-dinitrophenyl; Nva=L-norvaline) for to remove unspecific enzyme ligands prior to conducting MMP-3 (Calbiochem, San Diego, Calif.). In the intact Subsequent assayS. To 1 ml of extract, 100 till of gelatin peptide, Dpa or DNP quenches the MCA fluorescence. Sepharose resin is added in a microassay tube, the tube is Cleavage of the peptide causes release of the fluorescent mixed, kept on ice for 30 minutes, and then centrifuged 5 MCA group which is then quantitated on a fluorometer minutes at 5,000 rpm. Supernatant is removed and used (Gemini XS, Molecular Devices, Sunnyvale, Calif.). The directly for assays as described in Example IL. assay is performed in TNCZ assay buffer (20 mM Tris-HCl; NaCl 150 mM; CaCL 5 mM; ZnCl2 0.5 mM; pH 7.5) with 0121 Extraction Process III: Organic Extraction human purified proteases (I. M. Clark: <>, Humana Press (2001). The Sub nolic extraction. 12 ml of cold dichloromethane is added and strate, primarily dissolved in DMSO is then redissolved in the mixture is thoroughly vortexed for 2 minutes. The TNCZ buffer for the assay. In a typical assay, 10 ul of mixture is kept on ice for 30 minutes and Vortexed after each purified enzyme (1-50 ng) and 5 ul of dissolved substrate 10 minutes period. The sample is centrifuged in a CorexTM (final concentration of 10 uM) is mixed in a final volume of 30 ml tube for 5 minutes at 4,500 rpm. The resulting 75ul (completed with TNCZ). All assays were performed in Supernatant is decanted in a 15 ml glass tube after filtration 96 well plate and the reaction is started by the addition of with a MiraclothTM filter. The final pellet is discarded. The Substrate. ASSays are measured (excitation 325 nm, emission organic Solvent is evaporated under vacuum and the phase is 392 nm) for 20, 40 and 60 minutes. dissolved with dimethylsulfoxide (DMSO). This extract is 0128. Measurement of Human Cathepsin Land KActiv therefore referred as the Potential Pre-Extract C, which was ity with Fluorogenic Peptidic Substrate. further purified by Solid phase extraction prior to analysis by enzymatic assay. 0.129 Human recombinant cathepsins L and K are over expressed in P. Pastoris according to Krupa J C, Mort J S. 0123. In order to assay the Potential Pre-Extract C, the (2000), Anal Biochem 283(1):99-103. The assay is similar to organic extract is diluted 1:10 in a Solution of the previous except for the auto-quenched peptidic Substrate: DMSO:Methanol:Tris (20 mM, pH 7.5) (10:50:40) (Solu Z-Arg-Phe-AMC, 2HCl (Bachem , Torrance, tion A), ie, 220 ul of extract is added to 2.0 ml of solution Calif.) and reaction buffer. Assays for Cathepsin L are A. After 10 Seconds of vigorous Vortex, the mix is Sonicated performed in 20 mM acetate pH 5.5, 1 mM EDTA buffer and for 10 Seconds. Dissolved extracts are Subsequently applied assays for Cathepsin K in 20 mM acetate pH 4.2, 1 mM to a solid phase extraction plate (Discovery SPE-96, Sigma EDTA. Assays are monitored with fluorometer settled at Chemical Co., St-Louis, Mo.). After initial conditioning of excitation 380 nm/emission 460 nm wavelengths (Krupa J the columns with 1 ml of methanol, columns are equilibrated with Solution A, and extract Samples are deposited on the C, Mort J S. (2000), Anal Biochem 283(1):99-103). columns. Elution is completed with Solution A (final volume 0130. Measurement of Human MMP-9, Cathepsin B, of 2 ml) and this fraction is used directly in assays as Cathepsin G, and Human Leukocyte Elastase (HLE) Activ described in Example II. ity. Using the FASC Assay US 2004/0175439 A1 Sep. 9, 2004

0131 Human Cathepsin B and G and human leukocyte 0138 Extract Inhibition Assay elastase are obtained from Calbiochem (San Diego, Calif.). 0.139. Before a typical assay, aqueous extractsprepared as Human MMP-9 is purified as previously described. The described in Example I are preincubated with 1:10 of assay is based on the method described in Canadian Patent gelatin-Sepharose 4BTM for 30 minutes to remove fluores No. 2,189,486 (1996) and in St-Pierre et al., (1996) Cytom cence quenching. For the ethanolic extract, an initial hexane etry 25:374-380. For the assay, 5 uI of the purified enzyme extraction is performed and Samples are treated with 1:10 of (1-100 ng), 5 ul of concentrated buffer solution (20 mM gelatin-Sepharose 4B' to remove quenching. Tris-HCl, NaCl 150 mM; CaCL 5 mM; ZnCl2 0.5 mM; pH 7.5),and 5ul of gelatin-FITC beads are typically used in a 0140. In a typical fluorescent assay, 10 ul of purified final volume of 100 uI. The assay is performed by incubation enzyme at concentrations previously mentioned for the of the reaction mixture for 90 minutes at 37 C. The reaction enzymatic assay, 5 ul of dissolved fluorogenic peptid or 10 is stopped by the transfer of the mix in 0.5 ml of 20 mM Tris, All of dissolved fluorescent proteic Substrate (final concen 150 mM NaCl; pH 9.5 buffer. This tube is analyzed in a flow tration of 10 uM) and 40 ul of the aqueous, ethanolic or cytometer (Epics MCL, Beckman Coulter, Mississauga, organic extract to be tested and prepared as described in Ontario) as described in Canadian Patent No. 2,189,486 Example I are mixed in a final volume of 75 ul (completed (1996). with TNCZ for fluorogenic peptide substrate assay or 20 mM citrate pH 3.3 buffer for fluorescent protein substrate 0132) Measurement of Human Cathepsin D, Cathepsin B, assay). All assays are performed in 96 well plate and the Cathepsin G and HLE Activity with a Fluorogenic Proteic reaction is started by the addition of Substrate. ASSays are Substrate measured (excitation 325 nm, emission 392 nm for peptide 0133) Cathepsin D is purified from human MCF-7 cells and excitation 488 mm/emission 525 nm wavelengths for according to Stewart AJ, Piggott NH, May F E, Westley B protein) for 20, 40 and 60 minutes. Activity and inhibition R. (1994), IntJ Cancer 57(5):715-8. Cathepsin B, Cathepsin values are determined from the increase in fluorescence G and HLE are obtained as previously described. The 0141 For the FASC assay, 35 ul of the treated extract activities of Cathepsin D, Cathepsin B, Cathepsin G and prepared as described in Exampla I, 5 ul of the purified HLE are measured by an assay based on the increase of enzyme prepared as described previously, 5 ul of concen fluorescence of a proteic Substrate (Haemoglobin in the case trated buffer solution (TNCZ), and 5 ul of gelatin-FITC of Cathepsin D and B and beta-casein in the case of beads are typically used. The initial Step of the assay is the Cathepsin G and HLE) heavily labelled with Alexa-488 dye incubation of the reaction without beads for a 30 minutes (Molecular Probes, Eugene, Oreg.). The substrate, when period on ice to allow the binding of inhibitors to enzyme. highly labelled with the dye, will almost quench the dye Fluorescent beads are added and the reaction mix is incu fluorescence. Cleavage of the Substrate will result in an bated for 90 minutes at 37 C. The reaction isstopped by increase of the fluorescence which can be measured with a transfer of the mix in 0.5 ml of 20 mM Tris, 150 mM NaCl; Spectrofluorometer, and which is proportional to protease pH 9.5 buffer. This tube isanalyzed in the flow cytometer activity. Typically, 10 ul of purified human Cathepsin D, (Epics MCL. Beckman Coulter, Mississauga, Ontario) as Cathepsin B, Cathepsin G or HLE (10-50 ng) and 10 uIl of described in Canadian Patent Application No. 2,189,486 Hemoglobin-Alexa488 or beta-casein-Alexa488 (100 ng) (1996). are assayed in final volume of 75 ul adjusted with 20 mM citrate pH 3.3 buffer in the case of Cathepsins D and B or 0.142 Results of the inhibition studies are shown in TNCZ buffer in the case of Cathepsin G and HLE. The Tables 1-13. Table 2 reports the inhibition of human MMP-1 reaction is performed as already described except that the by aqueous (A), ethanolic (R) and organic (S) extracts for fluorescence is read at excitation 488 nm ?emission 525 nm. exemplary stressed (A and G) and non-stressed (T) plant wavelengths. Sources. Table 3 reports the inhibition of human MMP-2 by aqueous (A), ethanolic (R) and organic (S) extracts for 0134) Subtilisin Assay exemplary stressed (A and G) and non-stressed (T) plant Sources. Table 4 reports the inhibition of human MMP-3 by 0135 Subtilisin (isolated from B. Subtilisis) is purchased aqueous (A), ethanolic (R) and organic (S) extracts for from Fluka. ASSays are performed with a fluorogenic peptide exemplary stressed (A and G) and non-stressed (T) plant (Z-Gly-Gly-Leu-AMC, Bachem California, Torrance, Sources. Table 5 reports the inhibition of human MMP-9 by Calif.) as already described for MMPs with the following aqueous (A), ethanolic (R) and organic (S) extracts for modification: the assay is buffered with 20 mM Tris, 150 exemplary stressed (A and G) and non-stressed (T) plant mM NaCl; pH 7.5 and the results are read at excitation 380 Sources. Table 6 reports the inhibition of human Cathepsin nm/emission 460 nm wavelengths. B by aqueous (A), ethanolic (R) and organic (S) extracts for 0.136 Clostripain Assay exemplary stressed (A and G) and non-stressed (T) plant Sources. Table 7 reports the inhibition of human Cathepsin 0137 Clostripain from Clostridium histolyticum (Wor D by aqueous (A), ethanolic (R) and organic (S) extracts for thington Lakewood, N.J.) is prepared and activated as exemplary stressed (A and G) and non-stressed (T) plant described by manufacturer's protocol. The activity is deter Sources. Table 8 reports the inhibition of human Cathepsin mined by using Z-Arg-Arg-AMC, 2HCl (Calbiochem, San G by aqueous (A), ethanolic (R) and organic (S) extracts for Diego, Calif.) as a fluorogenic peptidic Substrate and the exemplary stressed (A and G) and non-stressed (T) plant incubation buffer is 75 mM phosphate, pH 7.6. The reaction Sources. Table 9 reports the inhibition of human Cathepsin is performed as already described except that the fluores L by aqueous (A), ethanolic (R) and organic (S) extracts for cence is read at excitation 380 nm ?emission 460 nm wave exemplary stressed (A and G) and non-stressed (T) plant lengths. Sources. Table 10 reports the inhibition of human Cathepsin US 2004/0175439 A1 Sep. 9, 2004 16

K by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant TABLE 1-continued Sources. Table 11 reports the inhibition of HME by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary MMP-1. Inhibition stressed (A and G) and non-stressed (T) plant Sources. Table Nom latin Stress extrait 12 reports the inhibition of bacteria Subtilisin by aqueous Inhibition (%) (A), ethanolic (R) and organic (S) extracts for exemplary Beckmannia eruciformis A. O 24.1 stressed (A and G) and non-stressed (T) plant Sources. Table BetaB vulgaris A. R 41.2 13 reports the inhibition------of bacterial cloStripain by aqueous Brassicaeta vulgaris napus spp. Maritina A. O 44.126.3 (A), ethanolic (R) and organic (S) extracts for exemplary Brassica oleracea A. S 28.6 stressed (A and G) and non-stressed (T) plant Sources. The Brassica oleracea A. R 33.8 inhibition------is reported as percentage (%) of inhibition------of Brassica Oileracearapa A. OR 1OO.O61.4 Substrate degradation as compared with the degradation Civinific peta A. R 40.2 without extract. The inhibition is reported as percentage (%) Cannelia Sinensis A. O 39.3 of inhibition of Substrate degradation as compared with the C ciliili A . apsicum annuum degradation without extract. Capsicum fruitesCens A. R 39.4 Chenopodium bonus-henricus A. O 1OO.O Example III Chenopodium bonus-henricus A. R 37.3 Chenopodium quinoa A. O 66.3 0143. Examplary Purification of Inhibitory Activity Chrysanthenum coronarium A. R 37.4 Found in an Extract Cichorium intybus A. R 22.0 Cichorium intybus A. S 66.9 0144) Extracts were separated by HPLC on an Agilent C. A g 4. 1100 system (San Fernando, Calif.). Briefly, 100 uL of a Crataegus sp A. O 1OO.O crude extract prepared as described in Example I was Cucunnis Anguria A. S 34.2 applied on a C18 reverse-phase column (Purospher RP-185 Cucurbita moschata A. O 27.3 um, 40x125 mm (HP), Agilent, San Fernando, Calif.). ymbopognthis pepo citratus A. O 1OO.O84.9 Elution of compounds was achieved with a linear gradient of Cymbopogon citratus A. R 22.1 10-85% acetonitrile. Fractions were collected, evaporated, Cyperus esculentius A. R 25.8 resuspended in aqueous buffer and then reanalysed for their Cyperts eculents A. O 28.1 ------Dactylis glomerata A. O 25.5 inhibition activity on Specific enzymes as already described. Dciticii.S Cairoid A. O 43.4 Fractions of interest (demonstrating a biological activity) Daucus Carota A. R 1OO.O where then reisolated at a larger Scale for further analysis Dipsacus Sativus A. O 35.3 and characterization. Dirca palustris A. S 47.9 Eruca weSicaria A. R 33.7 0145 The invention being thus described, it will be Eschscholzia Californica A. O 61.1 Eschscholzia californica A. R 74.1 obvious that the same may be varied in many ways. Such Fiilipendula rubra A. O 51.7 variations are not to be regarded as a departure from the Foeniculum vulgare A. O 86.2 Spirit and Scope of the invention, and all Such modifications Fragaria x ananassa A. O 23.7 as would be obvious to one skilled in the art are intended to fragaria Xananassa A i g be included within the scope of the following claims. GainSogaragariax ananassaciliata A. R 29.7 Gallium odoratum A. O 48.8 TABLE 1. Gaultheria hispidula A. R 23.9 Glycine max A. R 24.7 MMP-1. Inhibition Glycine max A. S 29.6 Glycine max A. O 1OO.O Nom latin Stress extrait Inhibition (%) Guizotia abyssinica A. S 39.4 Hamamelis virginiana A. R 49.1 Achillea millefolium A. O 22.2 Helianthus Tuberosus A. O 95.9 Acorus Caianus A. O 1OO.O Heitotropium arborescens A. R 25.0 Actinidia arguta A. O 56.4 Hordeum hexastichon A. O 1OO.O Agastache foeniculum A. S 30.4 Hordeum vulgare A. O 46.2 Alchemilia mollis A. 4 36.4 Vulgare A. O 43.8 Allium cepa A. O 61.4 Inula helenium A. O 25.8 Allium grande A. R 46.5 Lathyrus Sativus A. O 27.1 Allium porrum A. R 25.0 Leonurus cardiaca A. O 34.4 Allium porrum A. O 98.9 Levisticum officinale A. R 31.7 Allium Sativum A. O 42.5 Lolium multiflorum A. O 39.0 Allium Sativum A. R 98.7 Lotus coniculatus A. O 1OO.O Allium SchoenopraSun A. R 22.3 Malva Sylvestris A. R 22.8 Ailium TuberoSun A. R 29.9 Matricaria recutita A. O 25.1 Allium TuberoSun A. O 1OO.O Matteucia pensylvanica A. R 48.1 Althaea officinalis A. S 21.6 Medicago Sativa A. R 25.1 Angelica archangelica A. S 45.9 Melissa officinalis A. O 1OO.O Anthenis nobilis A. R 34.5 Mentha piperita A. O 60.1 Aralia nudicaulis A. O 1OO.O Mentha Suaveolens A. O 35.1 Annoracia rusticana A. O 31.2 Nepeta cataria A. O 1OO.O Arnoracia rusticana A. S 39.7 Nicotiana rustica A. R 20.7 Aronia melanocarpa A. R 39.8 Origanum vulgare A. R 60.5 Aster sp A. O 67.6 Origanum vulgare A. O 73.2 US 2004/0175439 A1 Sep. 9, 2004 17

TABLE 1-continued TABLE 1-continued

MMP-1. Inhibition MMP-1. Inhibition Nom latin Stress extrait Inhibition (%) Nom latin Stress extrait Inhibition (%) Perilla frutescens A. R 74.4 Allium Sativum G R 53.2 Perilla frutescens A. O 92.4 Allium tuberoSun G R 68.3 Petroselinum crispum A. R 77.4. Althaea officianalis G O 47.7 Phacelia tanacetifolia A. R 52.8 Althaea officinalis G S 3O.7 Phaseolus coccineus A. R 2O.9 Althaea officinalis G S 44.3 Phaseolus coccineus A. S 34.2 Althea officinalis G R 83.6 Phaseolus Vulgaris A. S 29.2 Anethum graveolens G S 44.3 Phaseolus vulgaris A. R 56.1 Apium graveolens G R 27.7 Phaseolus Vulgaris A. R 6O.O Arnoracia rusticana G O 51.8 Phaseolus Vulgaris A. O 1OO.O Arnoracia rusticana G S 47.1 Phlox paniculata A. O 1OO.O Aronia melanocarpa G S 66.5 Pimpinella anisum A. S 1OO.O Artemisia dracunculus G S 79.0 Pimpinella anisum A. R 72.2 Artemisia dracunculus G R 50.3 Plantago Coronopus A. R 23.7 Asparagus Officinalis G O 96.4 Plectranthus sp. A. O 25.0 Bellis perennis G R 44.1 Poa compressa A. O 31.5 Beta vulgaris spp. Maritima G R 43.7 Potentilla anSerina A. R 71.2 Beta vulgaris spp. Maritima G O 34.9 Pysalis ivocarpa A. R 32.1 Betula glandulosa G S 40.8 Raphanus raphanistrum A. O 31.5 Borago officinalis G O 30.3 Raphanus Sativus A. O OO.O Borago officinalis G R 29.7 Raphanus Sativus A. O 30.2 Brassica cepticepa G R 21.9 Rheum officinale A. O 79.1 Brassica oleracea G O 33.6 Rheum rhabarbarium A. R 22.9 Brassica oleracea G O 1OO.O Rheum rhabarbarium A. R 32.8 Brassica rapa G O 42.5 Ribes nigrum A. O OO.O Brassica rapa G R 40.2 Ribes nigrum A. R OO.O Calamintha nepeta G O 28.7 Ribes Saiivum A. R 48.6 Calendula officinalis L G O 1OO.O Ribes Sylvestre A. S 26.5 Cannelia Sinensis G O 46.4 Ribes uva-crispa A. R OO.O Campanula rapuncutus G R 27.2 Rubus Canadensis A. R 46.1 CapSella bursa-pastoris G R 24.1 Rubus Canadensis A. R 53.1 Capsicum annum G O 36.0 Rubus idaeus A. R OO.O Chaerophyllum bulbosum G R 38.9 Salvia Officianalis A. O OO.O Chenopodium quinoa G O 1OO.O Saivia Sciarea A. S 43.8 Cichorium intybus G S 44.6 Satureia montana A. R OO.O Circium arvense G R 30.3 Soianum dulcanara A. S 43.8 Citrulius ianatus G R 21.2 Soianum melanoceraSun A. R 37.2 Cucurbita pepo G O 59.5 Soianum tuberosum A. R OO.O Cucurbita Pepo G O 40.2 Sorghum dochna A. O OO.O Cuminum cyninum G R 25.5 Stachys byzantina A. S 28.9 Cymbopogon citratus G R 33.7 Stellaria media A. S 33.1 Datura Stranonium G O 73.5 Tanacetum parthenium A. O 28.9 Daucus Carota G O 86.0 Tanacetum vulgare A. R 76.O Daucus Carota G O 27.9 Taraxacum officinale A. O 65.7 Dryopteris filix-mas G O 21.9 Thymus praecox subsp arcticus A. O 64.2 Erysimum perofskianum G O 24.4 Thymus praecox subsp arcticus A. R 88.2 Fagopyrun esculentum G O 1OO.O Thymus vulgaris A. R 42.7 Foeniculum vulgare G O 28.0 Thymus x citriodorus A. O 34.7 Foeniculum vulgare G R 57.3 Trichosanthes kirillowii A. R 31.8 Gaultheria hispidula G O 44.2 Trifolium hybridum A. R 96.O Gaultheria procumbens G R 94.8 Trifolium incamatum A. R 1OO.O Giechona hederacea G O 25.5 Trifolium pannonicum A. R 27.7 Glycine max G S 1OO.O Trifolium repens A. R 79.5 Glycyrrhiza glabra G O 24.9 Vaccinium augustifolium A. R 52.5 Guizotia abyssinica G R 30.3 Vaccinium macrocarpon A. O 64.5 Helenium hoopesii G O 28.6 Vicia Satiya A. O 60.8 Helianthus annuus G O 33.6 Vicia Satiya A. R 28.6 Helianthus tuberosus G O 54.4 Vicia villosa A. R 64.7 Hordeum vulgare G O 28.8 Vicia villosa A. O 57.3 Vulgare G R 28.1 Vigna Sesquipedalis A. O 33.O Hypericum henryi G R 8O.O Vigna Sesquipedalis A. R 24.4 Iberis anara G O 44.6 Vigna unguiculata A. R 20.6 Lactuca Sativa G R 25.3 Vitia spp A. R 72.6 Lathyrus Sylvestris G O 90.2 Vitia spp A. O 1OO.O Lavandula angustifolia G R 22. Zea Mays A. R 99.2 Lepidium Sativum G S 29.5 Zea Mays A. O 1OO.O Levisticum officinale G O 1OO.O Abelnochus escutenius G R 37.6 Lolium multiflorum G O 24.9 Aconitun napeius G O 1OO.O Lolium multiflorum G R 27.1 Allium anpeiopraSun G R 33.4 Lotus corniculatus G O 52.2 Allium ascaionicum G R 31.5 Lycopersicon eSculentum G R 24.4 Allium cepa G O 34.4 Lycopersicon pimpinellifolium G R 30.3 Allium cepa G R 36.4 Maius hupehensis G R 65.8 US 2004/0175439 A1 Sep. 9, 2004 18

TABLE 1-continued TABLE 1-continued

MMP-1. Inhibition MMP-1. Inhibition Nom latin Stress extrait Inhibition (%) Nom latin Stress extrait Inhibition (%) Maiva verticiliata G R 43.1 articus G R 73.1 Matricaria reciutita G S 1OO.O Thymus x citriodorus G O 52.2 Matteucia pensylvanica G R 57.5 TrichoSanthes kirillowii G O 35.9 Melissa officinalis G O 28.5 Trifolium hybridum G R 76.O Mentha piperita G O 36.O Trifolium incarnatum G R 73.4 Mentha Spicata G S 20.3 Trifolium pannonicum G R 24.8 Mentha Spicata G S 26.O Trifolium repens G R 48.5 Mentha Suaveolens G O 60.5 Triticosecale spp. G R 48.5 Nepeta cataria G O 24.1 Triticum spelta G R 22.9 Nicotiana rustica G R 28.1 Tropaeoium nails G S 23.4 Nicotiana tabacunn G R 40.6 Urtica dioica G O 96.4 Oenothera biennis G R 28.4 Vaccinium corymbosum G S 6O.7 Oenothera biennis G O 1OO.O Vaccinium corybosum G R 61.4 Origanum vulgare G S 1OO.O Vaccinium angustifolium G R 54.7 Origanum vulgare G O 20.1 Vicia Satiya G R 68.8 Origanum vulgare G O 85.4 Vicia Satiya G R 31.5 Oryza Sativa G R 53.3 Vicia villosa G O 1OO.O Panax quinquefolius G S 1OO.O Vicia cillosa G R 35.5 Panicum miliaceum G S 1OO.O Vigna Sesquipedalis G R 23.O Passiflora caerula G O 2O.9 Vitia spp G R 36.9 Pastinaca Satiya G R 68.4 Withania Sonnifera G O 44.0 Pastinaca Satiya G O 1OO.O Xanthium Strunnarium G R 37.6 Pennisetum alopecuroides G R 1OO.O Zea mayS G O 1OO.O Petroselinum crispum G R 73.O Aconitum napeius T R 1OO.O Phaiaris canariensis G O 1OO.O Agaricus bisporus T R 58.9 Phaseolus coccineus G R 29.9 Agaricus bisporus T O 1OO.O Phaseolus coccineus G R 67.6 Allium anpeiopraSun T R 43.3 Phaseolus coccineus G O 32.4 Allium ascaionicum T R 34.5 Phaseolus vulgaris G R 33.4 Allium Cepa T R 53.5 Phaseolus vulgaris G R 6O2 Allium cepa T O 45.8 Phaseolus vulgaris G R 22.3 Allium grande T R 43.2 Phaseolus vulgaris G O 87.7 Allium Schoenopra Sun T R 47.1 Phlox paniculata G O 89.3 Allium tuberoSun T R 74.6 Physalis pruinosa G O 37.O Allium tuberoSun T O 33.6 Plantago Coronopus G R 48.1 Aloe vera T R 34.1 Plantago major G O 47.O Althaea officinalis T S 47.8 Plectranthus sp. G O 97.2 Amelanchier alnifolia T R 59.1 Potentilla anSerina G R 22.O Ananas COmoSuS T O 1OO.O Prunella vulgaris G O 21.2 Anthenis nobilis T O 22.7 Raphanus Raphanistrum G O 95.9 Anthriscus cerefolium T O 56.8 Raphanus Sativus G O 67.7 Apium graveolens T R 29.8 Reseda Odorata G O 40.6 Aralia nudicaulis T O 1OO.O Rheum officinale G O 82. Arnoracia rusticana T O 58.9 Rheum rhabarbarium G R 48. Artemisia dracunculus T O 1OO.O Ribes Nigrum G R 1OO.O Asparagus Officinalis T R 25.2 Ribes Sylvestre G O 42.9 Atriplex hortensis T R 44.7 Ricinius communis G O 73.5 Bellis perennis T R 58.1 Rubus Phoenicalasius G R 31.4 Beta vulgaris T R 37.3 Ruta graveolens G R 1OO.O Betula glandulosa T O 23.5 Salvia Officinalis G R 1OO.O Boletus edulis T S 64.2 Santolina G R 28. Brassica iuncea T R 35.6 Satureia hortensis G R 1OO.O Brassica napus T O 1OO.O Satureia repandra G O 57. Brassica oleracea T R 33.2 Scrophularia nodosa G R 41.6 Brassica oleracea T O 49.7 Scutelaria laterifiora G S 72. Cannelia Sinensis T O 24.7 Sium Sisarun G O 99.7 Cannelia Sinensis T R 45.7 Soianum dulcanara G R 65.4 Canna edulis T R 26.2 Soianum melanoceraSun G R 32.4 Carium carvi T O 1OO.O Solanum melongene G O 1OO.O Chaerophyllum bulbosum T R 40.9 Soianum tuberosum G S 46.4 Chrysanthemun coronarium T R 48.1 Sorghum caffronun G R 1OO.O (Chip Suey) Sorghum dochna G R 51.4 Chrysanthenum coronarium T R 29.9 Sorghum dochna G R 39.6 Chrysanthenum coronarium T R 1OO.O Sorghum Sudanense G O 97.4 Cichorium endivia T R 20.5 Stachys byzantina G O 41.4 Cichorium endivia T R 21.9 Stellaria media G O 33.8 Cichorium intybus T S 50.6 Symphytum officinale G O 52.O Cichorium intybus T R 31.7 Tanacetum parthenium G O 79. Cichorium intybus T R 52.9 Tanacetum vulgare G O 1OO.O Citrulius ianatus T O 1OO.O Taraxacum officinale G S 25.9 Citrus paradisi T O 40.6 Teucrium chamaedrys G O 1OO.O Cocos nucifera T O 27.2 Teucrium chamaedrys G R 48.0 Conus Canadensis T S 44.9 US 2004/0175439 A1 Sep. 9, 2004 19

TABLE 1-continued TABLE 1-continued

MMP-1. Inhibition MMP-1. Inhibition Nom latin Stress extrait Inhibition (%) Nom latin Stress extrait Inhibition (%) Crithmun maritinum T R 32.3 pour pre T R 28.9 Cucunnis anguria T O 22.6 Phytolacca americana T O OO.O Cucurbita noSchata T O 33.5 Plectranthus sp. T O 73.8 Cucurbita noSchata T R 32.3 Pleurotus spp. T O OO.O (Early Butternut) Poa compressa T O 22.3 Cucurbita pepo T O 89.0 Poa pratensis T O 73.1 Cuminum cyninum T R 543 Populus Tremula T O OO.O Curcuna zedoaria T S 1OO.O Prunella vulgaris T O 38.0 Cymbopogon citratus T O 42.6 Psoralea corylifolia T S 96.4 Datura metel T O 24.8 Pteridium aquilinum T R OO.O Datura metel T R 25.5 Raphanus raphanistrum T O OO.O DioScorea batatas T R 1OO.O Raphanus Sativus T R 33.7 Dipsacus Sativus T O 85.O Dryop teris filix-mas T O 46.4 Raphanus Sativus T R 28.0 Erigeron Canadensis T O 1OO.O Raphanus Sativus T O OO.O Eruca weSicaria T R 30.9 Reseda luteola T S 69.6 Erysimum perofskianum T O 23.O Reseda Odorata T O 51.8 Eschscholzia californica T O 37.8 Rheum officinale T O 46.7 Eschscholzia californica T R 20.8 Rheum officinale T S OO.O Fagopyrun eSculentum T O 1OO.O Ribes nigrum T R 3O.O Fagopyrun tartaricum T R 78.5 Ribes Sativum T R 61.7 Foeniculum vulgare T O 63.4 Ribes Sylvestre T R 75.4 Foeniculum vulgare T O 27.2 Ricinius communis T S OO.O Forsythia x intermedia T S 32.O RoSmarinus officinalis T R 29.0 Fragaria x ananassa T S 33.O Rubus canadensis T R 86.1 GainSoga ciliata T R 25.8 Sabal Serrulata T R OO.O Gaultheria procumbens T O 46.8 Salvia Officinalis T O OO.O Hedeoma pullegioides T O 73.6 Sambucus Canadensis T O 24.8 Helianthus tuberosus T O 39.3 Hordeum vulgare T O 32.4 Satureja nontana T R OO.O Huniulus lupulus T O 21.1 Satureia repandra T S 27.2 Hypericum henryi T R 29.3 Satureja repandra T O 36.4 Hypericum perforatum T R 42.7 Satureia repandra T R 42.O Iberis anara T O 29.5 Scrophularia nodosa T R 68.8 Iponea aquatica T R 22.9 Secale cereale T O 1OO.O Lathyrus Sativus T R 69.4 Setaria italica T R 23.2 Laurus nobilis T O 70.2 Silybum marianum T O 73.5 Lavandula latifolia T O 1OO.O Soianum melongena T R 20.1 Culinaris T O 70.2 Soianum tuberosum T S 24.4 Lepidium Sativum T O 1OO.O Solidago virgaurea T R 71.4 Levisticum officinale T O 1OO.O Sorghum dochna T O 22.5 Lolium multiflorum T O 35.1 Stachys byzantina T O 39.2 Lunaria annua T O 1OO.O Stellaria media T O 43.3 pimpinellifolium T R 24.4 Symphytum officinale T O 58.7 Maius hupehensis T R 73.1 T heni T O 1OO.O Malus sp. T R 80.9 anacetum parthenium Tanacetum vulgare T O 32.5 Malva Sylvestris T R 34.7 T inal T S 27.8 Malva Sylvestris T O 1OO.O araxacum officinale Manihot esculenta T R 33.O Teucrium chamaedrys T R 62.9 Melissa officinalis T O 1OO.O Teucrium chamaedrys T O 1OO.O Melissa officinalis T O 1OO.O Thalpsi arvense T O 21.2 Mentha Suaveolens T S 39.7 Thymus praecox subsp arcticus T R 60.9 Nigella Sativa T R 58.9 Tragopogon porrifolium T R 24.6 Nigella Sativa T R 1OO.O Trifolium incamatum T R 33.7 Ocinum Basilicum T R 1OO.O Trifolium pannonicum T R 72.4 Origanum majorana T O 41.5 Trifolium repens T R 72.4 Origanum vulgare T O 29.8 Triticosecale spp. T R 33.7 Origanum vulgare T R 33.1 Tropaeoium nails T R 1OO.O Panay quinquefolius T R 75.2 Tropaeoium nails T O 31.5 Passiflora spp. T S 32.O Vaccinium angustifolium T O 1OO.O Pastinaca sativa T R 20.8 Vaccinium angustifolium T S 42.1 Perroselinum crispum T R 55.4 Vaccinium macrocarpon T S 30.9 Petroselinum crispum T R 76.1 Vicia villosa T R 35.5 Petroselinum crispum T O 24.1 Peucedanum oreaselinum T O 21.0 Vigna sesquipedalis T R 24.0 Phacelia tanacetifolia T R 48.6 Vigna unguiculata T R 31.6 Phaiaris canariensis T O 56.4 Vinca minor T O 28.7 Phaseolus coccineus T R 22.7 Withania Sonnifera T O 26.9 Phaseolus nungo T R 47.4 Xanthium Strunnarium T O 30.9 Phaseolus vulgaris T R 40.O Zea mayS T R 20.1 Phaseolus vulgaris T O 29.4 Zea mayS T O 32.2 Phoenix dactylifera T R 46.3 US 2004/0175439 A1 Sep. 9, 2004

0146) -continued

MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Chrysanthemum coronarium 49.7 Achillea millefolium 21.9 Critrysanthemun coronarium 47.3 Achillea millefolium 63.0 Chrysanthenum coronarium 26.7 Achillea millefolium 1OO.O Cicer arietinium 22.0 Aconitun napeius 71.O Cicer arietinium 23.6 Alcea rosea 67.9 Cichorium intybus 21.1 Alchemilia mollis 64.4 Cichorium intybus 1OO.O Allium ascaionicum 2O.9 Citrulius ianatus 65.5 Allium cepa 84.3 Citrufius lanatus 96.3 Allium grande 36.7 Citrulius ianatus 1OO.O Allium porrum 1OO.O Coix Lacryma-Jobi 32.2 Allium porum 51.9 Conus Canadensis 52.8 Allium porum 66.7 CoSnoS Sulphureus 72.5 Allium Sativum 1OO.O Crataegus spp 1OO.O Allium SchoenopraSun 73.5 Cryptotaenia Canadensis 50.6 Allium TuberoSun 24.3 Cryptotaenia Canadensis 51.3 Allium TuberoSun 83.6 Cucumis anguria 53.4 Allium TuberoSun 89.3 Cucunnis Anguria 84.9 Aloe vera 69.7 Cucunnis melo 91.7 Althaea officinalis 27.6 Cucurbita Maxina 34.9 Althaea officinalis 64.7 Cucurbita Maxina 41.7 Anaranthus gangeticus 29.4 Cucurbita noSchata 36.8 Anethum graveolens 1OO.O Cucurbita noSchata 37.4 Apium graveolens 25.1 Cucurbita pepo 48.1 Apium graveolens 52.1 Cucurbita pepo 85.7 Aralia cordata 66.4 Curcuna zedoaria 21.0 Aralia cordata 92.2 Curcuna zedoaria 32.1 Aralia nudicaulis 29.4 Curcurbita maxina 27.0 Arctium minus 28.4 Cymbopogon citratus 34.5 Arnoracia rusticana 2O2 Cymbopogon citratus 1OO.O Arnoracia rusticana 55.0 Cymbopogon martinii 47.4 Arrhenatherun elatius 40.2 Dactylis glomerata 20.6 Artemisia dracunculus 39.7 Dactylis glomerata 75.0 Asparagus Officinalis 29.3 Daucus Carota 44.5 Atriplex hortensis 33.6 Daucus Carota 70.5 Avena Sativa 37.2 Dipsacus Sativus 40.4 Beta vulgaris 45.4 Dirca palustris 27.2 Beta vulgaris 95.9 DolichoS Labiab 54.2 Beta vulgaris spp. Maritima 1OO.O Dryopteris filix-mas 76.3 Brassica chinensis 49.6 Echinacea purpurea 42.9 Brassica napus 28.5 Eleusine Coracana 37.5 Brassica Napus 52.4 Eleusine Coracana 1OO.O Brassica Napus 82.4 Erigeron Canadensis 45.7 Brassica nigra 29.2 Eruca weSicaria 80.2 Brassica oleracea 31.2 Eschscholzia californica 42.4 Brassica Oileracea 31.4 Cana edulis 45.5 Brassica oleracea 64.O Canna edulis 2O2 Brassica oleracea 68.7 CapSella bursa-pastoris 35.5 Brassica oleracea 75.3 capsicum annuum 61.5 Brassica oleracea 1OO.O Capsicum annuum 89.8 Brassica rapa 27.6 Fagopyrun tartaricum 71.0 Brassica rapa 33.4 Filipendula rubra 36.3 Brassica rapa 57.6 Foeniculum vulgare 41.6 Brassica rapa 58.1 Foeniculum vulgare 84.4 Brassica rapa 84.5 Foeniculum vulgare 1OO.O Calamintha nepeta 65.O Forsythia intermedia 35.8 Cannelia Sinensis 21.9 Fragaria x ananassa 97.2 Cannelia Sinensis 26.5 GainSoga ciliata 54.O Cannelia Sinensis 79.O Galium odoratum 34.3 Capsicum annuum 1OO.O Galium odoratum 1OO.O Capsicum frutescens 66.6 Gaultheria hispidula 35.8 1OO.O Gaultheria hispidula 1OO.O Capsicum frutescens Giaux maritina 46.5 Carthanus tinctorius 21.3 Glycine max 27.0 Carthanus tinctorius 21.5 Glycine Max 43.1 Chaerophyllum bulbosom 57.2 Glycine max 1OO.O Chelidonium maius 34.4 Guizotia abyssinica 29.8 Chenopodium bonus - henricus 43.5 Guizotia abyssinica 32.5 Chenopodium bonus - henricus 1OO.O Hamamelis virginiana 75.7 Chenopodium bonus-henricus 76.4 Helianthus annuus 69.0 Chenopodium quinoa 92.0 Helianthus Tuberosus 22.2 Chrysanthemum coronarium 48.6 Helianthus tuberosus 69.7 US 2004/0175439 A1 Sep. 9, 2004 21

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MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Helianthus Tilberosus 1OO.O Pimpinella anisum 1OO.O Hordeum hexaStichon 22.3 Plantago Coronopus 36.0 Hordeum hexaStichon 34.9 Plantago Coronopus 38.4 Hordeum hexaStichon 86.9 Plantago Coronopus 53.6 Hordeum vulgare 74.8 Plantago major 65.3 Hordeum vulgare subsp. Vulgare 34.5 Plectranthus sp. 74.2 Hordeum vulgare subsp. Vulgare 74.2 Poa compressa 37.3 HySSopus officinalis 57.5 Poa compressa 49.8 Inula helenium 26.8 Poa compressa 1OO.O Ipomoea Batatas 20.1 Polygonum pensylvanicum 63.5 Lathyrus Sativus 28.7 Polygonum pensylvanicum 72.9 Lathyrus Sativus 1OO.O Polygonum persicaria 27.5 Lathyrus Sylvestris 42.4 Polygonum persicaria 43.0 Lavandula latifolia 39.1 Poterium Sanguisorba 1OO.O Lepidium Sativum 20.1 Poterium Sanquisorba 84.2 Lepidium Sativum 49.O Pteridium aquilinum 45.1 Levisticum officinale 23.O Pteridium aquilinum 1OO.O Levisticum officinale 29.8 Pysalis ivocarpa 87.3 Linum usitatis.Simum 56.9 Raphanus raphanistrum 32.2 Lolium multiflorum 41.5 Raphanus Sativus 25.3 Lolium multiflorum 92.3 Raphanus Sativus 47.5 Lotus corniculatus 95.5 Melilotus albus 50.7 Lotus tetragonolobus 76.7 Melilotus albus 1OO.O Lycopersicon eSculentum 35.3 Melissa officinalis 42.4 Lycopersicon eSculentum 78.1 Mentha pullegium 88.3 Lycopersicon eSculentum 85.6 Mentha Spicata 94.8 Lycopersicon pinpinoliifolium 74.9 Mentha Suaveolens 82.9 Maiva noSchata 21.5 Nepeta cataria 1OO.O Maiva noSchata 44.5 Nicotiana rustica 24.0 Maiva verticiliata 22.O Nicotiana rustica 1OO.O Matricaria reciutita 40.9 Rosa rugosa 83.2 Matricaria reciutita 67.3 RoSmarinus officinalis 68.2 Melaleuca alternifolia 65.O Rubus idaeus 81.9 Eschscholzia californica 75.O Rubus ideaus 73.4 Eschschotzia californica 88.8 Runnex Acetosa 24.2 Fagopyrun eSculentum 1OO.O Runnex Acetosa 85.5 Fagopyrun tartaricum 38.6 Runnex Acetosa 1OO.O Fagopyrun tartaricum 40.3 Rumex crispus 46.7 Nicotiana tabacunn 42.5 Rumex crispus 1OO.O Nicotiana tabacunn 61.1 Ruta graveolens 1OO.O Nigella Sativa 81.7 Saccharum officinarum 80.8 Ocimum tenuiflorum 23.1 Salix purpurea 56.7 Oenothera biennis 28.6 Salvia Officinalis 24.1 Origanum majorana 52.9 Salvia Officinalis 91.8 Origanum majorana 1OO.O Saivia Sciarea 99.7 Origanum vulgare 66.8 Santolina Chamaecyparissus 83.8 Panax quinquefolius 31.8 Satureia hortensis 79.1 Pastinaca Satiya 27.7 Satureia hortensis 1OO.O Pastinaca Satiya 33.8 Satureia montana 60.4 Petasites japonicus 26.2 Satureia montana 76.1 Petroselinum crispum 69.1 Scorzonera hispanica 22.1 Phaiaris canariensis 28.4 Secale cereale 47.2 Phaiaris canariensis 29.7 Secale cereale 67.2 Phaiaris canariensis 94.3 Senecio vulgaris 23.2 Phaseolus coccineus 30.8 Senecio vulgaris 76.6 Phaseolus coccineus 79.5 Sesamun indicum 1OO.O Phaseolus coccineus 80.9 Sesamun indicum 1OO.O Phaseolus nungo 59.8 Soianum dulcanara 54.5 Phaseolus vulgaris 47.3 Soianum melanoceraSun 45.4 Phaseolus Vulgaris 74.4 Soianum melanoceraSun 85.2 Phaseolus vulgaris 83.2 Soianum melanoceraSun 88.7 Phaseolus Vulgaris 1OO.O Soianum melongena 42.5 Phlox paniculata 23.7 Soianum melongena 85.9 Phlox paniculata 81.7 Sonchus oleraceus 25.6 Physalis alkekengi 23.5 Sorghum caffronun 39.6 Physalis Ixocarpa 85.8 Sorghum dochna 3O.O Physalisixocarpa 91.5 Sorghum dochna 48.0 Physalis Pruinosa 25.7 Sorghum dochna 62.O Physalis Pruinosa 83.5 Sorghum durra 72.1 Phytolacca decandra 31.5 Sorghum durra 94.6 Phytolacca decandra 38.5 Sorghun Sudanense 1OO.O Pimpinella anisum 1OO.O Spinacia Oileracea 23.6 US 2004/0175439 A1 Sep. 9, 2004 22

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MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Stachys affinis A. R 74.4 Taraxacum officinale A. R 59.1 Stachys byzantina A. R 48.4 Thymus praecox subsp arcticus A. R 43.5 Stachys byzantina A. O 1OO.O Thymus vulgaris A. S 30.1 Stellaria graminea A. S 20.8 Thymus x citriodorus A. R 1OO.O Stellaria graminea A. R 37.5 TrichoSanthes kirillowii A. S 29.2 Stellaria media A. R 49.O TrichoSanthes kirillowii A. O 42.1 Stellaria media A. S 50.7 Trigonelia foenungraecum A. O 53.4 Symphytum officinale A. R 44.2 Triticosecal spp. A. R 44.8 Tanacetum cinerariifolium A. R 1OO.O Triticium aestivium A. R 65.5 Raphanus Sativus A. R 83.5 Triticum durum A. O 53.9 Raphanus Sativus A. R 84.7 Apium graveolens G S 54.1 Raphanus Sativus A. O 1OO.O Apium graveolens G R 84.1 Rheum officinale A. O 44.0 Aralia nudicaulis G R 51.8 Ribes nigrum A. O 1OO.O Arctium minius G S 25.4 Ribes nigrum A. R 1OO.O Arnoracia rusticana G O 52.1 Ricinius communis A. O 1OO.O Aronia melanocarpa G S 22.5 Rosa rugosa A. R 25.2 Aronia melanocarpa G R 82.3 Rosa rugosa A. S 26.6 Artemisia dracunculus G R 53.6 Triticum spelta A. R 26.4 Artemisia dracunculus G R 58.8 Triticum spelta A. S 36.7 Artemisia dracunculus G S 1OO.O Triticum spelta A. O 51.9 Artemisia dracunculus G O 1OO.O Tropaediurn nails A. R 25.8 Asclepias incarnate G S 26.9 Urtica dioica A. O 22.9 Asparagus Officinalis G S 24.0 Urtica dioica A. S 30.6 Asparagus Officinalis G R 65.9 Vaccinhim Corymbosum A. R 1OO.O Asparagus Officinalis G O 95.0 Veratrun viride A. R 33.2 Aster spp G O 48.4 Verbascum thapsus A. S 22.9 Beckmannia eruciformis G O 24.8 Veronica beccabunga A. R 52.8 Bellis perennis G O 52.6 Veronica officinalis A. R 84.2 Beta vulgaris G S 45.3 Vicia Satiya A. R 1OO.O Beta vulgaris G R 1OO.O Vicia villosa A. S 32.9 Beta vulgaris spp. Maritima G R 1OO.O Vicia villosa A. R 1OO.O Brassica cepticepa G R 52.9 Vigna angularis A. R 54.O Brassica chinensis G R 41.9 Vigna Sesquipedalis A. S 48.3 Brassica iuncea G R 22.8 Vigna Sesquipedalis A. R 73.O Brassica Napus G S 22.9 Vigna Sesquipedalis A. O 96.6 Brassica oleracea G R 45.5 Vigna unguiculata A. R 70.7 Brassica oleracea G R 47.1 Vinca minor A. S 22.1 Brassica oleracea G S 62.9 Vinca minor A. R 88.4 Brassica oleracea G R 77.9 Vitis sp. A. S 2O.9 Brassica oleracea G O 1OO.O Vitis sp. A. R 30.4 Brassica rapa G S 26.5 Xanthium Sibiricum A. S 39.2 Brassica rapa G R 38.9 Xanthium Sibiricum A. R 47.8 Brassica Rapa G R 53.6 Xanthium Sibiricum A. O 70.1 Calamintha nepeta G S 20.4 Zea mayS A. R 1OO.O Calamintha nepeta G O 78.0 Zea Mays A. O 1OO.O Cannelia Sinensis G O 1OO.O Abelnochus esculentus G S 21.6 Campanula rapunculus G R 60.6 Abelnochus esculentus G R 79.3 Canna edulis G O 78.1 Achillea millefolium G O 62.7 CapSella bursa-pastoris G S 3O.7 Aconitun napeius G O 82.O CapSella bursa-pastoris G R 60.6 Acorus Caianus G S 1OO.O Capsicum annuum G S 70.8 Ageratun Conyzoides G S 49.3 Capsicum annuum G O 8O.O Alcea rosea G R 64.4 Capsicum annuum G R 1OO.O Alchemilia mollis G S 21.5 Capsicum fruitesCens G S 63.2 Alchemilia mollis G R 30.2 Capsicum fruitesCens G R 1OO.O Alchemilia mollis G O 55.7 Carthamus tinctorius G R 1OO.O Allium anpeiopraSun G O 36. Centaurea Solstitialis G S 46.4 Allium anpeiopraSun G R 52.8 Allium tuberoSun G O 54.5 Allium ascaionicum G O 68.9 Allium tuberoSun G R 85.9 Allium cepa G S 40.2 Aloe vera G R 53.6 Allium cepa G R 66.4 Althaea officinalis G S 37.4 Allium cepa G O 1OO.O Altheaa officinalis G S 42.4 Allium grande G R 36.4 Anaranthus caudathus G S 30.9 Allium Sativum G S 29.5 Anaranthus caudathus G O 56.7 Allium Sativum G R 68.4 Anaranthus gangeticus G S 23.1 Allium Sativum G O 1OO.O Anethum graveolens G S 23.9 Allium SchoenopraSun G S 47. Angelica archangelica G S 22.0 Allium SchoenopraSun G R 61.7 Angelica archangelica G S 24.9 Allium tuberoSun G S 23.8 Apium graveolens G O 33.O Tanacetum parthenium A. S 30.4 Apium graveolens G R 44.8 Tanacetum vulgare A. S 28.6 CoSnoS Sulphureus G S 79.4 Tanacetum vulgare A. R 1OO.O Cucunnis Sativu.S. G S 39.9 US 2004/0175439 A1 Sep. 9, 2004 23

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MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Cucunnis Sativus 39.9 Levisticum officinale 80.7 Cucurbita maxina 33.9 Lolium multiflorum 34.5 Cucurbita maxina 43.4 Lotus corniculatus 32.9 Cucurbita maxina 1OO.O Lotus corniculatus 1OO.O Cucurbita noSchata 41.3 Lotus tetragonolobus 79.9 Cucurbita pepo 42.8 Lycoparsicon eSculentum 28.2 Cucurbita pepo 45.4 Lycopersicon eSculentum 75.4 Cucurbita Pepo 83.O Lycopersicon pimpinellifolium 81.4 Cuminum cyninum 66.2 Maius hupehensis 32.5 Curcuna zedoaria 33.9 Maius hupehensis 41.2 Cymbopogon citratus 65.8 Maiva noSchata 47.1 Cymbopogon martini motia 41.4 Malva Sylvestris 23.1 Cymbopogon martini motia 60.5 Maiva verticiliata 39.9 Dactylis glomerata 21.9 Matricaria recutita 3O.O Dactylis glomerata 61.2 Matricaria recutita 71.3 Datura Stranonium 27.0 Melaleuca attemifolia 58.3 Daucus carota 21.3 Melilotus aba 41.1 Daucus carota 31.O Melilotus albus 88.8 Daucus carota 1OO.O Melilotus abus 1OO.O Digitalis purpurea 30.9 Melissa officinalis 47.8 Dipsacus Sativus 63.6 Mentha arvensis 33.9 Dirca palustris 23.1 Mentha arvensis 6.3.3 DolichoS Labiab 33.O Mentha piperita 32.3 Dryopteris filix-mas 1OO.O Mentha piperita 85.9 Echinacea purpurea 93.4 Mentha piperita 1OO.O Eleusine Coracana 3O.O Mentha Spicata 28.9 Erigeron Speciosus 28.9 Mentha Spicata 37.5 Errhenatherunn elatius 55.6 Mentha Suaveotens 25.6 Eruca weSicaria 54.7 Mentha Suaveotens 70.3 Eschscholzia californica 47.9 Monnordica charantia 52.9 Eschscholzia californica 75.9 Monarda didyma 22.0 Fagopyrun tartaricum 41.1 Monarda didyma 1OO.O Filipendula rubra 38.5 Monarda fistulosa 26.0 Foeniculum vulgare 7O.O Guizotia abyssinica 36.8 Foeniculum Vulgare 1OO.O Guizotia abyssinica 1OO.O GainSoga ciliata 34.6 Hedeoma pullegioides 94.6 GainSoga ciliata 48.2 Helianthus annuus 35.5 Gaultheria hispidula 60.5 Helianthus annuus 75.0 Gaultheria hispidula 1OO.O Helianthus annuus 79.9 Gaultheria hispidula 1OO.O Helianthus Strunosus 1OO.O Giaux maritina 59.3 Helianthus tuberosus 64.2 Glycine max 21. Helichrysum thianschanicum 61.1 Glycine max 24.4 Helleborus niger 48.0 Glycine max 28. Hordeum hexastichon 26.8 Guizotia abyssinica Hordeum vulgare 65.4 Cerastium tonentOSun Hordeum vulgare subsp. Vulgare 75.8 Chenopodium bonus-henricus Huniulus lupulus 26.0 Chenopodium quinoa Hypericum henryi 2O2 Chenopodium quinoa Hypericum henryi 71.1 ChrysanthSmun coronarium HySSopus officinalis 1OO.O Chrysanthenum coronarium Pastinaca Satiya 24.3 Cioer arietinium Pastinaca Satiya 90.2 Cichorium endivia subspendivia Petroselinum crispum 87.6 Cichorium endivia subspendivia Petroselinum crispum 1OO.O Cichorium intybus Phaiaris canariensis 1OO.O Cichorium intybus Phaiaris canariensis 1OO.O Circium arvense Phaseolus acutifolius 79.6 Circium arvense Phaseolus coccineus 28.3 Citrulius ianatus Phaseolus coccineus 80.4 Citrulius ianatus Phaseolus nungo 37.2 Citrulius ianatus Phaseolus vulgaris 64.3 CoSnoS Sulphureus Phaseolus vulgaris 59.0 Iberis anara Phaseolus vulgaris 73.7 Inula helenium Phaseolus vulgaris 1OO.O Lactuca Sativa Phlox paniculata 37.7 Lactuca Serrioia Phlox paniculata 77.0 Laportea Canadensis Phlox paniculata 80.8 Lathyrus Sylvestris Physalisixocarpa 30.5 Lavandula angustifolia Physalisixocarpa 78.3 Lavandula latifolia Physalisixocarpa 80.9 Lepidium Sativum Physalis pruinosa 63.2 Lepidium Sativum Phytolacca americana 36.1 US 2004/0175439 A1 Sep. 9, 2004 24

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MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Phytolacca americana G O 1OO.O Sesamun indicum G S 34.3 Pimpinella anisum G S 26.1 Sesamun indicum G R 44.5 Pimpinella anisum G R 3O.O Silene vulgaris G S 34.1 Pisun Sativium G S 28.4 Sium Sisarun G O 1OO.O Plantago Coronopus G R 27.8 Solarium melanoceraSun G S 40.6 Plantago Coronopus G O 51.1 Soianum melanoceraSun G R 85.4 Plantago Coronopus G R 67.5 Soianum melongena G S 58.2 Plantago major G S 30.3 Soianum melongena G O 83.O Plantago major G O 64.6 Soianum melongena G R 85.6 Poa compressa G O 63.0 Poterium Sanguisorba G R 1OO.O Poa compressa G S 67.4 Poterium Sanquisorba G S 23.7 Poa compressa G R 89.0 Prunella vulgaris G S 26.7 Poa pratensis G S 28.2 Prunus cerasifera G R 95.3 Polygonum aviculare G R 1OO.O Raphanus Raphanistrum G R 41.7 Polygonun pensylvanicum G S 27.7 Raphanus Raphanistrum G S 43.5 Polygonun pensylvanicum G O 54.1 Raphanus Sativus G R 41.O Polygonun perSicaria G S 32.O Raphanus Sativus G S 44.6 Polygonun perSicaria G O 35.7 Raphanus Sativus G R 50.5 Polygonun perSicaria G R 1OO.O Raphanus Sativus G R 86.1 Portulaca oleracera G R 51.5 Raphanus Sativus G O 1OO.O Poterium Sanguisorba G O 89.9 Reseda Odorata G O 58.3 Nepeta cataria G S 23.4 Rheum officinale G O 3O.7 Nicotiana tabacunn G S 45.2 Ribes nigrum G O 543 Nigella Sativa G R 94.7 Ribes nigrum G R 63.8 Ocinum basilicum G S 23.O Ribes Sylvestre G R 1OO.O Ocinum basilicum G O 1OO.O Ricinius communis G R 41.5 Ocimum tenuiflorum G R 45.3 Ricinius communis G O 1OO.O Oerothera biennis G R 543 RoSmarinus officinalis G R 90.0 Origanum majorana G O 1OO.O Rubus idaeus G S 37.1 Origanum majorana G R 1OO.O Rubus ideaus G R 26.6 Origanum vulgare G R 93.3 Thymus vulgaris G S 23.3 Origanum vulgare G O 93.5 Thymus vulgaris G R 86.4 Origanum vulgare G S 97.4 Thymus x citriodorus G R 97.6 Oxalis Deppei G S 28.7 Tragopogon porrifolius G R 76.2 Oxalis Deppei G R 87.2 TrichoSanthes kirillowii G O 87.7 Oxalis Deppei G O 1OO.O Trigonelia foenungraecum G S 31.0 Oxyria digyna G R 54.5 Trigonelia foenungraecum G O 84.O Panicum miliaceum G O 71.1 Triticosecale spp G S 26.5 Panicum miliaceum G R 1OO.O Triticosecale spp G O 73.5 Panicum miliaceum G S 1OO.O Triticium aestivium G R 62.4 Passiflora caerula G S 26.3 Triticum durum G O 51.9 Passiflora caerula G R 72.1 Triticum spelta G S 24.5 Rubus Occidentalis G R 35.1 Triticum spelta G O 32.9 Rumex crispus G R 30.3 Triticum turgidium G O 25.1 Rumex crispus G S 1OO.O Tropaeoium nails G S 21.3 Rumex patientia G R 41.O Tropaeoium nails G R 45.6 Rumex patientia G S 41.9 Urtica dioica G S 21.3 Ruta graveolens G S 47.9 Urtica dioica G O 1OO.O Ruta graveolens G R 82.1 Valerianella locusta G O 32.2 Saccharum officinarum G R 1OO.O Veratrun viride G R 77.7 Salvia elegens G O 1OO.O Verbascum thapsus G S 34.O Salvia Officinalis G S 35.3 Veronica beccabunga G R 44.1 Salvia Officinalis G O 1OO.O Veronica officinalis G S 38.8 Salvia Officinalis G R 1OO.O Veronica officinalis G R 87.5 Sambucus ebulus G R 53.9 Viburnum trilobum G O 62. Santolina Chamaecyparissus G S 36.4 Vicia faba G S 22.2 Santolina Chamaecyparissus G O 69.5 Vicia Satiya G O 748 Santolina Chamaecyparissus G R 1OO.O Vicia Satiya G R 1OO.O Saponaria Oficinalis G S 29.8 Vicia villosa G R 1OO.O Satureia hortensis G O 97.4 Vigna angularis G R 65.2 Satureia hortensis G R 1OO.O Vigna Sesquipedalis G S 35.1 Satureia montana G O 59.2 Vigna Sesquipedalis G R 73.8 Satureia repandra G S 35.3 Vigna Sesquipedalis G O 1OO.O Satureia repandra G O 66.2 Vigna unguiculata G S 65.9 Scorzonera hispanica G S 24.5 Vigna unguiculata G R 84.5 Scrophularia nodosa G S 24.5 Vinca minor G S 22.1 Scrophularia nodosa G O 3O.O Vitis sp. G R 40.1 Scrophularia nodosa G R 55.6 Vitis sp. G O 74.7 Scutellaria lateriflora G S 20.3 Withania Sonnifera G S 37.3 Scutellaria lateriflora G R 83.1 Solarium tuberoSun G O 40.2 Secale cereale G O 51.1 Sonchus oleraceus G R 41.1 Senecio vulgaris G R 42.5 Sorghum dochna G S 25.0 US 2004/0175439 A1 Sep. 9, 2004 25

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MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Sorghum dochna 64.3 Adiantum pedatun 1OO.O Sorghum dochna 1OO.O Agaricus bisporus 52.1 Sorghun durira 60.1 Agaricus bisporus 65.6 Sorghum durra 1OO.O Ageratum conyzoides 26.7 Sorghum Sudanense 98.0 Agropyron repenS 30.2 Spinacia oleracea 24.9 Agrostis Stolonifera 1OO.O Spinacia oleracea 1OO.O Alcea rosea 63.7 Stachys byzantina 78.8 Alchemilia mollis 28.6 Stellaria graminea 29.3 Allium anpeiopraSun 55.9 Stellaria media 33.4 Allium anpeiopraSun 60.4 Stellaria media 45.4 Cannelia Sinensis 43.8 Symphytum officinale 57.5 Cannelia Sinensis 66.2 Tanacetum cinerariifolium 1OO.O Canna edulis 1OO.O Tanacetum parthenium 28.2 Cantha relius cibariaS 26.0 Tanacetum vulgare 25.2 Capsicum annuum 54.6 Tanacetum vulgare 39.3 Capsicum annuum 1OO.O Tanacetum vulgare 81.2 Capsicum fruitesCens 60.9 Taraxacum officinale 51.1 Capsicum fruitesCens 1OO.O Thymus fragantissinus 29.9 Carex morrowii 24.4 Thymus fragantissinus 55.3 Carica papaya 20.8 Thymus praecox subsp arcticus 27.7 Carthamus tinctorius 39.6 Thymus serpyllum 74.9 Carya cordiformis 1OO.O Allium ascaionicum 20.4 Cerastium tonentOSun 54.8 Allium ascaionicum 73.4 Chaerophylium bulbosum 42.2 Allium cepa 33.8 Chaerophylium bulbosum 74.3 Allium cepa 35.6 Chelidonium maius 20.3 Allium cepa 48.0 Chenopodium quinoa 76.O Allium cepa 78.6 Chrysanthemum coronarium 30.6 Allium grande 32.4 Chrysanthemum parthenium 57.2 Allium SchoenopraSun 67.7 chrysanthemun coronarium 56.5 Allium tuberoSun 38.8 Chrysanthenum coronarium 81.6 Allium tuberoSun 82.5 Cicer arietinium 32.2 Allium tuberoSun 85.2 Cichorium endivia subspendivia 27.1 Aloe vera 74.6 Cichorium endivia subsp. Endivia 26.9 Althaea officianalis 37.7 Cichorium endivia subsp. Endivia 64.5 Althaea officinalis 55.3 Cichorium intybus 22.7 Althaea officinalis 72.3 Cichorium intybus 53.5 Anaranthus caudathus 53.5 Cinicifuga racenOSa 41.1 Anaranthus gangeticus 28.1 Cinicifuga racenOSa 68.4 Ananas COmoSuS 37.9 Circium arvense 42.5 Ananas COmoSuS 1OO.O Circium arvense 64.5 angelica archangelica 41.3 Citrulius ianatus 72.4 Anthenis nobilis 1OO.O Citrulius ianatus 92.2 Anthenis nobilis 1OO.O Citrulius ianatus 1OO.O Antnriscus cerefolium 21.9 Citrus innettoides 77.1. Anthriscus cerefolium 67.1 Atriplex hortensis 28.4 Apium graveolens 35.5 Avena Sativa 31.3 Apium graveolens 52.1 Avena Sativa 70.6 Aralia cordata 1OO.O Avena Sativa 1OO.O Aralia nudicaulis 31.2 Averrhoa caramboia 44.0 Arctium minus 31.3 Bellis perennis 82.O Arctium minus 73.7 Beta vulgaris 33.7 Arnoracia rusticana 49.8 Beta vulgaris 1OO.O Arrhenatherun elatius 1OO.O Betula glandulosa 53.5 Artemisia dracunius 1OO.O Boletus edulis 21.8 Asclepias incarnata 32.3 Borago officinalis 42.3 Asparagus Officinalis 48.2 Borago officinalis 78.5 Withania Sonnifera 91.O Brassica hirta 53.1 Xanthium Sibiricum 38.4 Brassica hirta 68.9 Xanthium Sibiricum 1OO.O Brassica Napus 45.1 Xanthium Strunnarium 37.7 Brassica Napus 82.9 Xanthium Strunnarium 39.6 Brassica oleracea 38.8 Xanthium Strunnarium 40.O Brassica oleracea 49.7 Zea mayS 43.3 Brassica oleracea 75.5 Zea mayS 64.4 Brassica oleracea 77.0 Zea mayS 68.3 Brassica oleracea 77.2 Perilla frutescens 1OO.O Brassica rapa 25.4 Abies lasiocarpa 2O2 Brassica rapa 37.9 Abies lasiocarpa 59.1 Brassica rapa 47.7 Achillea millefolium 84.7 Brassica rapa 64.7 Aconitun napeius 22.O Brassica rapa 81.8 Aconitun napeius 1OO.O Calamintha nepeta 57.6 US 2004/0175439 A1 Sep. 9, 2004 26

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MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Calendula officinalis 32.6 HySSopus officinalis 1OO.O Cannelia Sinensis 21.0 Iberis anara 1OO.O Cucurbita pepo 98.9 Juniperus communis 1OO.O Cuminum cyninum 54.O Kochia Scoparia 25.2 Curcuna zedoaria 1OO.O Koeleria glauca 23.1 Cymbopogon citratus 21.0 Lactuca Sativa 70.5 Cymbopogon martini motia 27.5 Lactuca Serrioia 34.1 Cynara Scolynus 23.1 Laportea Canadensis 61.3 Cynara Scolynus 83.4 Lathyrus Sylvestris 48.6 Cyperus esculentius 1OO.O Laurus nobilis 73.6 Dactilis Gionerata 30.8 Lavandula angustifolia 35.O Dactilis Gionerata 34.5 Lavandula angustifolia 1OO.O Daucus carota 27.1 Lavandula latifolia 77.1. Daucus carota 56.8 Lepidium Sativum 35.2 Daucus Carota 1OO.O Lepidium Sativum 48.1 Digitalis purpurea 38.4 Lepidium Sativum 72.9 Dirca palustris 45.9 Levisticum officinale 38.7 DolichoS labiab 46.6 Levisticum officinale 60.3 Dryopteris filix-mas 29.5 Linum usitatis.Simum 24.7 Dryopteris filix-mas 1OO.O Lolium multiflorum 39.8 Echinacea purpurea 59.3 Lolium multiflorum 74.1 Echinacea purpurea 87.8 Fagopyrun tartaricum 1OO.O Eleusine Coracana 28.6 Festuca rubra 51.6 Eleusine Coracana 8O.O Festuca rubra 56.6 Erigeron Canadensis 1OO.O Festuca rubra 71.7 Eruca weSicaria 60.5 Foeniculum vulgare 36.5 Erysimum perofskianum 28.2 Foeniculum vulgare 41.4 Erysimum perofskianum 85.2 Foeniculum vulgare 1OO.O Eschscholzia californica 49.9 Fortunella spp 53.9 Eschscholzia californica 74.5 Fragaria xananassa 28.1 Fagopyrun eSculentum 52.9 GainSoga ciliata 43.2 Fagopyrun tartaricum 25.6 GainSoga ciliata 73.3 Fagopyrun tartaricum 68.4 Galium odoratum 42.O Citrus innon 43.6 Galium odoratum 94.2 Citrus paradisi 21.8 Giaux Maritina 24.8 Citrus paradisi 90.9 Glycine max 37.2 Citrus Sinensis 46.7 Glycine max 1OO.O Colocasia sp 43.4 Glycine max 1OO.O Colocasia sp 84.3 Glycine max 1OO.O Conchorus oitorius 22.7 Gossypium herbaceum 48.7 Coriandrum Sativum 20.4 Guizotia abyssinica 26.8 Cornus Canadensis 66.O Guizotia abyssinica 1OO.O CoSnoS Sulphureus 47.1 Hedeoma pullegioides 20.3 Crataegu.S. Subnois 21.2 Hedeoma pullegioides 72.7 Crataegu.S. Subnois 94.3 Helianthus annuus 56.1 Cucunnis anguria 49.4 Helianthus Strunosus 1OO.O Cucunnis anguria 84.1 Helianthus tuberosus 25.3 Cucunnis meio 56.6 Helianthus tuberosus 28.1 Cucunnis meio 92.4 Helianthus tuberosus 78.6 Cucunnis meio 1OO.O Helianthus tuberosus 91.5 Cucumis metuliferus 29.5 Helichrysum angustifolium 83.4 Cucunnis Sativus 28.3 Helichrysum angustifolium 88.3 Cucurbita maxina 26.7 Helichrysum thianschanicum 26.0 Cucurbita maxina 34.7 Heliotropium arborescens 1OO.O Cucurbita maxina 62.1 Nepeta cataria 69.0 Cucurbita noSchata 3O.7 Nepeta cataria 1OO.O Cucurbita noSchata 33.4 Nicotiana rustica 52.8 Cucurbita noSchata 48.3 Nicotiana rustica 88.1 Cucurbita noSchata 98.8 Nicotiana tabacunn 50.3 Cucurbita noSchata 1OO.O Nicotiana tabacunn 91.5 Cucurbita pepo 45.8 Nigella Sativa 34.2 Cucurbita pepo 80.2 Nigella Sativa 90.3 Helleborus niger 23.O Nigella Sativa 1OO.O Hibiscus cannabinus 37.9 Ocinum Basilicum 21.6 Hordeum vulgare 75.9 Ocinum Basilicum 1OO.O Hordeum vulgare supsp vulgare 20.5 Ocimum tenuiflorum 44.5 Hordeum vulgare supsp vulgare 62.3 Oenothera biennis 48.2 Huniulus lupulus 44.7 Onobrychis viciifolia 34.4 Huniulus lupulus 70.6 Onobrychis viciifolia 35.6 Hypericurn henryi 76.8 Opuntia sp. 23.5 Hypericurn henryi 99.8 Origanum vulgare 20.7 Hypericurn perforatum 38.8 Origanum vulgare 76.7 US 2004/0175439 A1 Sep. 9, 2004 27

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MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Origanum vulgare T O 1OO.O Petasites Japonious T S 21.9 Oryza Sativa T R 60.8 Petroselinum crispum T R 52.8 Oxalis Deppei T S 22.2 Peucedanum Oreaselinum T R 41.9 Oxalis Deppei T R 81.4 Phaiaris canariensis T R 41.1 Passiflora caerulea T S 36.9 Phaiaris canariensis T O 1OO.O Passiflora caerulea T R 87.O Phaseolus acutifolius T R 88.2 Passiflora spp T R 54.6 Phaseolus coccineus T S 22.2 Pastinaca Satiya T S 24.8 Phaseolus coccineus T R 36.4 Pastinaca Satiya T R 74.7 Phaseolus coccineus T R 86.7 Lonicera ranosissina T S 34.4 Phaseolus coccineus T O 1OO.O Lonicera ranosissina T O 80.5 Phaseolus nungo T S 43.0 Lonicera Syringantha T R 58.4 Phaseolus vulgaris T S 62.9 Lotus corniculatus T S 36.O Phaseolus vulgaris T R 71.9 Lotus corniculatus T O 1OO.O Phaseolus vulgaris T R 73.O Lotus tetragonolobus T R 76.1 Phaseolus vulgaris T O 1OO.O Lunaria annua T R 47.4 Phlox paniculata T R 23.1 Lycopersicon eSculentum T R 69.7 Phlox paniculata T R 92.8 Lycopersicon pimpinellifolium T R 58.7 Physalis alkekengi T R 39.5 Maius hupehensis T R 53.1 Physalisixocarpa T R 36.7 Maius hupehensis T S 1OO.O Physalisixocarpa T R 75.9 Malus sp. T R 72.6 Physalis pruinosa T R 65.6 Maiva noSchata T O 96.7 Physalis pruinosa T R 71.0 Maiva verticiliata T R 35.8 Physalis pruinosa T O 1OO.O Manihot esculenta T R 53.7 Physalis pruinosa T O 1OO.O Melaleuca altenifolia T S 21.5 Phytolacca decandra T S 39.3 Melaleuca attemifolia T O 78.7 Phytolacca decandra T O 42.O Melilotus albus T R 79.7 Pimpinella anisum T S 27.9 Melilotus officinalis T S 34.6 Pimpinella anisum T R 35.8 Melilotus officinalis T R 1OO.O Pimpinella anisum T O 49.9 Melissa officinalis T O 1OO.O Pimpinella anisum T R 55.5 Mentha piperita T S 24.5 Pisun Stativum T S 22.3 Mentha pullegium T O 1OO.O Plantago Coronopus T R 35.2 Mentha Suaveolens T O 2O.9 Plantago Coronopus T R 46.0 Miscanthus Sinensis Andress T S 69.1 Plantago Coronopus T O 73.5 Monnordica charantia T R 54.9 Scolynus hispanicus T R 35.8 Monarda didyma T S 31.3 Scorzorera hipanica T R 99.4 Monarda fistulosa T S 21.3 Scrophularia nodosa T S 29.1 Monarda fistulosa T O 1OO.O Scrophularia nodosa T R 90.1 Montia perfoliata T R 67.2 Scrophularia nodosa T O 1OO.O Musa paradisiaca T R 47.3 Scutellaria laterifiora T S 30.9 nasturtium officinale T S 55.7 Scutellaria laterifiora T R 63.9 Nepeta cataria T S 20.7 Secale cereale T O 1OO.O Plantago major T S 22.3 Senecio vulgaris T S 24.7 Plectranthus sp. T S 59.2 Senecio vulgaris T R 32.2 Pleurotus spp T R 26.6 Sesamun indicum T R 1OO.O Poa compressa T S 33.4 Silene vulgaris T S 25.6 Poa compressa T R 75.7 Sium Sisarun T O 81.4 Poa compressa T O 1OO.O Sium Sisarun T O 1OO.O Poa pratensis T S 25.4 Soianum melanoceraSun T S 28.0 Polygonun pensylvanicum T O 66.8 Soianum melanoceraSun T R 78.8 Polygonun pensylvanicum T R 73.3 Soianum melanoceraSun T R 99.6 Polygonun perSicaria T S 27.1 Soianum melongena T S 70.5 Polygonun perSicaria T O SO.8 Sorghum caffronun T S 28.1 Populus incrassata T O 74.3 Sorghum dochna T R 40.6 Populus incrassata T S 1OO.O Sorghum dochna T O 1OO.O Prunus armeniaca T R 55.0 Sorghum durra T R 29.7 Prunus ceraSils T O 1OO.O Sorghum durra T O 73.9 Prunus persica T S 26.O Reseda Odorata T O 71.3 Prunus persica T R 46.2 Rhamnus franguia T O 44.6 Psoralea corylifolia T S 47.4 Rhamnus franguia T R 74.4 Pteridium aquilinum T R 1OO.O Rheum officinale T O 73.9 Pyrus communis T R 42.8 Rheum officinale T S 1OO.O Raphanus raphanistrum T S 24.4 Ricinius communis T O 1OO.O Raphanus raphanistrum T R 56.9 RoSmarinus officinalis T O 1OO.O Raphanus raphanistrum T O 62.1 RoSmarinus officinalis T R 1OO.O Raphanus raphanistrum T O 1OO.O Rubus ideaus T R 78.1 Raphanus Sativus T R 48.9 Runnex acetoSella T R 42.2 Raphanus Sativus T S 59.8 Rumex crispus T O 73.1 Raphanus Sativus T R 81.6 Rumex patientia T S 52.0 Perroselinum crispum T R 85.2 Ruta graveolens T S 34.7 Perroselinum crispum T O 1OO.O Ruta graveolens T O 1OO.O PerSea annericana T R 43.1 Saccharum officinarum T S 59.6 US 2004/0175439 A1 Sep. 9, 2004 28

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MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Saccharum officinarum T R 66.1 Tragopogon sp. T R 2O.O Saivia elegans T S 36.3 Trifolium repens T R 79.7 Saivia elegans T O 44.3 Trigonelia foenium graecum T O 28.4 Salvia Officinalis T S 28.2 Trigonelia foenium graecum T S 34.8 Salvia Officinalis T O 1OO.O Triticosecale spp T S 28.5 Saivia Sciarea T R 38.6 Triticosecale spp T O 1OO.O Sambucus Canadensis T S 36.3 Triticium aestivium T R 32.9 Sambucus Canadensis T R 64.5 Triticium aestivium T O 67.7 Sambucus Canadensis T O 1OO.O Triticum durum T O 47.7 Sanguisorba minor T O 73.1 Triticum spelta T O 37.1 Sanguisorba minor T R 1OO.O Triticum turgidiumn T O 41.2 Santolina Chamaecyparissus T O 27.7 Tropaeoium nails T S 42.7 Santolina Chamaecyparissus T R 1OO.O Tropaeoium nails T R 77.6 Saponaria Oficinalis T R 1OO.O Tsuga diversifolia T R 53.4 Satureia hortensis T O 62.2 Vitis sp. T S 36.3 Satureia hortensis T R 1OO.O Vitis sp. T O 72.2 Satureia montana T S 34.7 Weigela coraeensis T S 32.9 Satureia montana T O 36.3 Weigela coraeensis T R 61.5 Satureia montana T R 1OO.O Withania Sonnifera T S 36.1 Satureia repandra T O 47.O Withania Sonnifera T O 83.3 Satureia repandra T S 47.6 Xanthium Sibiricum T S 32.1 Satureia repandra T R 846 Xanthium Sibiricum T R 33.2 Typha latifolia T S 29.2 Xanthium Sibiricum T O 62.4 Urtica dioica T S 29.5 Xanthium Strunnarium T S 47.2 Vaccinium angustifolium T R 59.4 Xanthium Strunnarium T O 74.3 Vaccinium angustifolium T R 1OO.O Zea mayS T R 55.7 sin macrocarpon T Zea mayS T O 1OO.O CCili PiccGee Waterianella EP T S 22.7 Zingiber officinale T R 79.0 Valerianella locusta T O 24.8 Veronica beccabunga T R 33.3 Veronica officinalis T R 59.2 Veronica officinalis T O 1OO.O 0147) Viburnum trilobum T O 71.2 Vicia faba T S 25.5 TABLE 3 Vicia faba T R 27.0 Vicia Satiya T O 56.6 MMP-3 Vicia villosa T R 1OO.O Vigna angularis T R 49.2 Nom latin Stress Extrait Inhibition (%) Vigna Sesquipedalis T R 77.4. Vigna Sesquipedalis T O 1OO.O Achillea millefolium A. O 21.4 Vigna unguiculata T S 27.2 Allium TuberoSun A. S 32.5 Vigna unguiculata T R 59.0 Anethum graveolens A. S 26.0 Vinca minor T R 39.2 Anthenis nobilis A. R 20.3 Vitis sp. T R 31.9 Anthenis tinctoria A. R 58.0 Sorghum Sudanense T R 74.6 Apium graveolens A. R 34.1 Sorghum Sudanense T O 1OO.O Arctium minius A. R 53.9 Spinacia oleracea T S 28.5 Arctium minius A. O 1OO.O Spinacia oleracea T O 62.7 ArctostaphyloS uva-ursi A. S 58.6 Stachys byzantina T R 68.9 Aronia melanocarpa A. R 32.2 Stachys byzantina T O 1OO.O Artemisia Absinthium A. O 1OO.O Stellaria media T S 21.4 Artemisia dracunculus A. R 23.4 Stellaria media T R 87.1 Artemisia dracunculus A. S 63.O Stipa capiliata T R 37.5 Aster sp A. O 42.4 Symphytum officinale T O 58.5 Atropa belladonna A. O 23.8 Tanacetum cinerariifolium T O 1OO.O Beta vulgaris A. S 24.1 Tanacetum cinerariifolium T R 1OO.O Beta vulgaris A. O 42.9 Tanacetum parthenium T R 1OO.O Beta vulgaris A. O 94.3 Tanacetum vulgare T R 20.8 Beta vulgaris A. R 97.9 Taraxacum officinale T R 76.3 Beta vulgaris var. Condiwata A. O 21.2 Teucrium chamaedrys T O 75.6 Brassica napus A. S 25.0 Thalpsi arvense T O 64.1 Brassica napus A. O 1OO.O Thymus fragantissinus T S 21.4 Brassica oleracea A. S 39.9 Thymus praecox subsp arcticus T S 36.4 Canna edulis A. S 39.6 Thymus pseudoianuginosus T S 21.1 Capsicum annuum A. S 35.4 Thymus pseudoianuginosus T O 75.4 Capsicum fruitesCens A. S 27.2 Thymus serpyllum T O 64.2 Cichorium intybus A. O 2O2 Thymus vulgaris T R 71.5 Cichorium intybus A. R 26.5 Thymus X citriodorus T S 27.6 Cichorium intybus A. S 28.2 Tragopogon porrifolium T S 44.8 Citrulius ianatus A. S 21.7 Tragopogon porrifolius T O 39.1 Citrulius ianatus A. O 27.8 Tragopogon porrifolius T R 57.9 Citrulius ianatus A. R 34.4 US 2004/0175439 A1 Sep. 9, 2004 29

TABLE 3-continued TABLE 3-continued

MMP-3 MMP-3 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Coix Lacryma-Jobi A. S 37.3 Salvia Officinalis A. R 43.2 Coix Lacryma-Jobi A. O 78.1 Santolina Chamaecyparissus A. R 27.0 CoSnoS Sulphureus A. R 26.8 Scutellaria laterifiora A. R 53.5 Crataegu.S. Subnois A. S 22.3 Solarium melongena A. S 21.8 Crataegu.S. Subnois A. R 61.6 Solidago Canadensis A. S 27.4 Cucunnis anguria A. S 27.8 Stachys affinis A. S 1OO.O Cucurbita Maxina A. S 28.9 Stellaria media A. O 24.4 Cucurbita noSchata A. S 32.9 Tanacetum vulgare A. R 62.1 Cucurbita pepo A. S 50.9 Thymus praecox subsp arcticus A. S 28.4 Datisca cannabina A. R 43.3 Thymus praecox subsp arcticus A. O 31.8 Datisca cannabina A. S 1OO.O TrichoSanthes kirillowii A. S 23.2 Digitalis purpurea A. R 2O.O Vaccinium Corymbosum A. R 1OO.O Dipsacus Sativus A. R 64.8 Vaccinium macrocarpon A. S 48.6 Dirca palustris A. S 29.6 Vaccinium augustifolium A. R 56.6 Dryopteris filix-mas A. R 22.O Hedeoma pullegioides A. O 51.7 Dryopteris filix-mas A. O 32.8 Helianthus tuberosus A. O 22.9 Echinacea purpurea A. O 1OO.O Hordeum vulgare subsp. vulgare A. S 36.0 Fagopyrun tataricum A. R 28.3 Hypericum henryi A. R 67.2 Fagopyrun tataricum A. O 29.7 Vitis sp. A. S 20.8 Filipendula rubra A. S 43.7 Vitis sp. A. O 21.5 Filipendula rubra A. R 63.2 Vitis sp. A. R 33.6 Fragaria x ananassa A. R 41.5 Xanthium Sibiricum A. S 27.3 Fragaria x ananassa A. S 67.1 Aconitum napeius G O 59.0 Fragaria x ananassa A. O 99.6 Agropyron repenS G O 69.4 Fragariax ananassa A. R 31.7 Alchemilia mollis G S 30.6 Gaultheria hispidula A. R 50.5 Alchemilia mollis G O 73.3 Glycyrrhiza glabra A. R 56.2 Allium grande G O 33.4 Hypericum perforatum A. R 31.7 Anethum graveolens G S 40.5 Hyssopus officinalis A. R 21.6 Aronia melanocarpa G O 1OO.O Iris versicolor A. R 53.6 Artemisia absinthium G S 31.3 Satistinctoria A. S 32.9 Artemisia absinthium G O 67.9 Levisticum officinale A. O 46.7 Artemisia dracunculus G S 1OO.O Lotus tetragonolobus A. R 26.2 Atropa belladonna G S 41.2 Matricaria reciutita A. S 43.5 Bellis perennis G S 48.4 Matteucia pensylvanica A. R 24.7 Brassica oleracea G S 26.4 Melissa officinalis A. S 30.3 Brassica oleracea G O 40.6 Mentha Suaveolens A. R 91.7 Brassica rapa G S 21.4 Nepeta cataria A. S 30.3 Capsicum annuum G S 35.O Nigella Sativa A. O 26.O Capsicum annuum G S 35.7 Ocinum tenuiflorum A. O 33.O Capsicum fruitesCens G S 27.5 Ocinum tenuiflorum A. R 49.8 Chelidonium maius G O 34.7 Perilla frutescens A. R 34.8 Cichorium intybus G R 34.4 Petasites japonicus A. R 38.0 Coix Lacryma-Jobi G S 2O2 Phaseolus nungo A. O 62.6 CoSnoS Sulphureus G O 32.9 Phaseolus vulgaris A. S 21.2 Crataegu.S. Subnois G S 2S6 Phaseolus vulgaris A. O 50.6 Crataegu.S. Subnois G R 28.6 Phaseolus Vulgaris A. R 1OO.O Cucumis anguria G S 33.6 Phlox paniculata A. S 46.4 Cucurbita maxina G S 44.6 Physalis alkekengi A. O 37.5 Cucurbita noSchata G S 33.4 Plantago major A. O 27.3 Cucurbita pepo G S 25.3 Polygonum aviculare linné A. S 24.8 Cymbopogon citratus G S 30.3 Polygonun perSicaria A. S 59.1 Cymbopogon martinii G S 61.1 Potentilia anSerina A. R 40.1 Daucus Carota G O 3O.O Poterium Sanguisorba A. R 75.7 Dryopteris filix-mas G S 26.0 Prunus cerasifera A. R 8O.O Dryopteris filix-mas G R 45.3 Ptaridium aquilinus A. R 39.6 Echinacea purpurea G O 51.8 Raphanus raphanistrum A. S 28.2 Echinochloa frumentacea G S 30.3 Raphanus Sativus A. S 64.4 Fagopyrun esculentum G R 50.9 Ribes nigrum A. O 47.6 Fagopyrun tartaricum G O 44.0 ribes uva-crispa A. R 21.0 Fagopyrun tartaricum G R 46.0 ribes uva-crispa A. O 1OO.O Filipendula rubra G S 53.1 Rosa rugosa A. S 21.4 Filipendula rubra G R 58.7 RoSmarinus officinalis A. R 27.3 Forsythia intermedia G O 52.9 Rubus allegheniensis A. R 81.0 Fragaria x ananassa G R 40.7 Rubus arcticus A. R 51.O Fragariax ananassa G R 28.1 Rubus Canadensis A. R 48.8 Gaultheria hispidula G R 72.8 Rubus idaeus A. S 28.5 Gaultheria hispidula G O 1OO.O Rubus idaeus A. R 35.1 Gaultheria procumbens G R 24.1 Rubus pubescens A. O SO.4 Glycine max G S 31.2 Rubus thibetanus A. O 39.1 Glycyrrhiza glabra G R 37.1 Rumex patientia A. S 24.8 Guizotia abyssinica G R 35.4 Ruta graveolens A. O 56.1 Hamamelis virginiana G S 29.1 US 2004/0175439 A1 Sep. 9, 2004 30

TABLE 3-continued TABLE 3-continued

MMP-3 MMP-3 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Hamamelis virginiana G R 67.1 Triticum turgidium G O 80.2 Helenium hoopesii G R 39.8 Vaccinium angustifolium G R 47.6 Vigna angularia A. O 23.1 Vaccinium angustifolium G R 48.1 Vigna Sesquipedalis A. O 37.8 Vaccinium angustifolium G R 71.0 Vigna unguiculata A. S 52.5 Vaccinium corymbosum G R 60.6 Vinca minor A. O 23.2 Vaccinium corymbosum G R 61.7 Iris versicolor G R 47.O Vaccinium corymbosum G O 99.4 Satistinctoria G S 32.1 Vaccinium macrocarpon G R 1OO.O Lavandula angustifolia G S 43.9 Vaccinium angustifolium G O 24.4 Levisticum officinale G O 51.4 Vaccinium angustifolium G R 41.5 Maius hupehensis G S 24.2 Valeriana officinalis G R 33.5 Maius hupehensis G R 37.2 Veronica officinalis G S 27.0 Malva Sylvestris G O 73.7 Vicia faba G O 31.2 Matricaria reciutita G S 31.5 Vicia faba G R 44.7 Melaleuca alternifolia G S 21.5 Vigna angularia G O 40.8 Melissa officinalis G S 32.8 Vigna angularis G S 39.4 Melissa officinalis G R 44.8 Vigna unguiculata G O 26.1 Melissa officinalis G O 82.4 Vitis sp. G R 62.4 Mentha piperita G R 77.3 Vitis sp. G S 6.3.3 Mentha pullegium G R 41.1 Vitis sp. G O 82.O Monarda didyma G S 31.8 Withania Sonnifera G S 22.4 Nepeta cataria G R 25.8 Xanthium Strunnarium G S 20.7 Nepeta cataria G O 84.9 Zea mayS G S 26.1 Nigella Sativa G O 44.9 Zea mayS G R 67.5 Ocinum tenuiflorum G R 23.7 Abies lasiocarpa T R 46.2 Oenothera biennis G S 25.6 Acorus Caianus T R 21.8 Origanum vulgare G S 28.6 Actinidia arguta T R 64.6 Origanum vulgare G R 31.2 Agropyron repenS T O 48.3 Pennisetum alopecuroides G S 49.9 Alchemilia mollis T R 1OO.O Petroselinum crispum G S 31.5 Alchemilia mollis T O 1OO.O Peucedanum oreaselinum G R 68.3 Allium cepa T R 39.8 Phaseolus acutifolius G R 25.4 Allium cepa T O 45.2 Phaseolus acutifolius G O 618 Allium tuberoSun T R 28.2 Phaseolus vulgaris G O 24.4 Allium tuberoSun T S 28.8 Phaseolus vulgaris G S 35.6 Alpinia officinarum T S 26.4 Phlox paniculata G S 27.2 Anelanchier alnitolia T R 78.3 Physalis alkekengi G R 26. Anelanchier Sanguinea x A. laevis T R 66.5 Physalis alkekengi G O 54.9 angelica archangelica T S 25.2 Plantago major G O 55.9 Apium graveolens T R 43.3 Plectranthus sp. G R 23.O Aralia cordata T S 31.5 Polygonun perSicaria G S 41. Aralia nudicaulis T S 37.7 Potentilla anSerina G R 55.4 Aralia nudicaulis T R 48.5 Poterium Sanguisorba G R 76.4 Aronia melanocarpa T S 26.0 Prunus cerasifera G R 55.3 Aronia melanocarpa T O 53.3 Ptaridium aquilinus G R 44.5 Aronia prunifolia T R 79.2 Rhaphanus Sativus G O 98. Artemisia absinthium T O 1OO.O Rheum X cultorum G R 27.0 Artemisia dracunius T S 42.O Ribes nidigrolaria G R 22.O Ayperus esculentius T O 67.8 Ribes SilveStris G R 88.8 Beta vulgaris T R 27.9 RoSmarinus officinalis G R 39.4 Beta vulgaris T S 33.2 Rubus idaeus G S 1OO.O Soianum melongena G S 21.1 Rubus ideaus G O 37.O Soianum tuberosum G S 27.6 Rubus Phoenicalasius G R 24.9 Sorghum dochna G S 23.7 Rubus pubescens G O 23.O Sorghum dochna G R 56.3 Rubus thibetanus G O 41.2 Symphytum officinale G S 25.2 Rumex patientia G S 36.2 Teucrium chamaedrys G S 75.4 Salvia Officinalis G O 34.5 Thymus praecox subsp arcticus G S 28.4 Salvia Officinalis G R 89.5 Thymus praecox subsp arcticus G O 52.1 Sanguisorba Officinalis G S 46.8 Carya cordiformis T R 27.5 Santolina Chamaecyparissus G R 33.7 Chaerophyllum bulbosum T S 27.1 Secale cereale G S 24.4 Chaerophyllum bulbosum T O 1OO.O Senecio vulgaris G R 37.6 Chelidonium maius T O 54.O Helianthus tuberosus G O 32.8 Chrysanthemum parthenium T S SO.4 Hordeum hexaStichon G S 60.9 Chrysanthenum coronarium T S 25.8 Huniulus lupulus G R 61.2 Cichorium intybus T R 23.9 Huniulus lupulus G S 90.5 Citrulius ianatus T S 33.2 Hypericum henryi G R 1OO.O Citrulius lanatus (Garden baby) T S 21.4 Hypericum perforatum G R 43.4 Citrus innettoides T O 39.2 HySSopus officinalis G S 25.1 Citrus innon T O 60.4 HySSopus officinalis G O 48.2 Conchorus oitorius T S 28.6 Thymus x citriodorus G R 25.3 Cornus Canadensis L T O SO.O Triticum durum G S 21.9 Cornus Canadensis L T R 80.6 US 2004/0175439 A1 Sep. 9, 2004 31

TABLE 3-continued TABLE 3-continued

MMP-3 MMP-3 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) CoSnoS Sulphureus T R 20.5 Nicotiana tabacunn T R 27.3 CoSnoS Sulphureus T S 27.0 Nigella Sativa T R 25.1 Crataegus sp T S 43.9 Ocinum Basilicum T R 2O2 Crataegu.S. Subnois T O 24.2 Ocnothera biennis T S 37.8 Crataegu.S. Subnois T R 55.1 Origanun nationara T R 45.2 Cucunnis anguria T S 33.2 Origanum vulgare T S 21.3 Cucumis Sativus Fanfare T S 35.4 Origanum vulgare T O 23.3 Cucurbita noSchata T S 30.4 Origanum vulgare T R 23.6 Cucurbita pepo T R 23.8 Origanum vulgare T O 37.2 Cucurbita pepo T S 46.6 Panicum miliaceum T S 20.6 Cuminum cyninum T S 23.1 Panicum miliaceum T S 3O.7 Curcuna zedoaria T S 20.8 Pastinaca Saiva T R 26.1 Cymbopogon citratus T S 39.7 Pastinaca Satiya T O 1OO.O Dolichus labiab T S 25.8 Peucedanum Oreaselinum T S 39.6 Dryopteris filix-mas T O 54.O Peucedanum Oreaselinum T R 53.4 Echinacea purpurea T S 20.4 Phaseolus vulgaris T S 21.8 Eriobotrya japonica T O 34.8 Phaseolus vulgaris T O 23.6 Eriobotrya japonica T S 42.9 Phaseolus vulgaris T O 59.8 Foericulum vulgare T O 33.1 Physalis alkekengi T O 55.5 Fragaria x ananassa T S 20.3 Physalis pruinosa T S 24.8 Fragaria x ananassa T R 42.8 Plantago major T O 77.1. Glycine max T O 26.3 Poa compressa T R 54.4 Glycine max T O 30.5 Polygonium chinense T O 36.3 Gossypium herbaceum T R 22.5 Polygonium chinense T R 61.4 Guizotia abyssinica T R 46.6 Polygonum persicaria T S 21.3 Hamamelis virginiana T S 33.1 Populus incrassata T S 50.7 Hamamelis virginiana T S 33.1 Populus incrassata T S 50.7 Hamamelis virginiana T R 44.8 Huniulus lupulus T R 77.6 Hedeona pullegiodes T O 46.8 Humulus lupulus T S 79.1 Helenium hoopesii T R 27.9 Huniulus lupulus T S 1OO.O Helianthus annus T S 22.7 Huniulus lupulus T R 1OO.O Helianthus Strunosus T O 3O.O Huniulus lupulus T S 1OO.O Heliotropium arborescens T O 53.7 Hypericum henryi T R 1OO.O Helleborus niger T S 40.5 Hypericum perforatum T O 99.3 Hibiscus cannabinus T O 34.O Hypomyces lactiflorum T O 20.5 Hordeum vulgare subsp. Vulgare T O 1OO.O Iris versicolor T R 48.5 Huniulus lupulus T S 24.9 Juniperus communis T R 33.8 Huniulus lupulus T R 55.1 Lactuca Serrioia T R 21.5 Beta vulgaris T O 53.0 Laportea Canadensis T S 37.7 Borago officinalis T O 55.7 RoSmarinum officinalis T R 48.2 Brassica Napus T O 71.9 Rubus arcticus T R 59.1 Brassica oleracea T O 37.O Rubus ideaus T O 21.5 Brassica oleracea T S 46.9 Rubus pubescens T O 51.8 Brassica rapa T S 36.7 Rubus thibetanus T O 33.7 Bronius inermis T R 42.8 Rumex patientia T S 34.4 Calendula officinalis L T S 28.4 Ruta graveolens T O 24.3 Camelia Sinensis syn. T R 86.4 Salvia (elegens) T O 37.2 Thea Sinensis Salvia (elegens) T R 42.9 Capsicum annus T S 29.7 Salvia Officinalis T R 67.3 Capsicum annus T R 43.7 Sambucus Canadensis T S 30.2 Capsicum frutescens (tabasco) T S 22.O Sanguisorba minor T R 21.0 Lavendula angustifolia T S 91.7 Sanguisorba minor T R 29.9 Lepidium Sativum T R 24.7 Sanguisorba minor T R 30.8 Levisticum officinale T O 24.9 Sanguisorba minor T R 44.5 Lolium perenne T S 22.3 Santolina T R 43.8 Lonicera ranosissina T R 42.5 Sarratula tinctoria T S 37.7 Lonicera Syringantha T R 21.1 Satureia montana T R 45.O Malus T O 53.1 Satureia repandra T S 46.3 Malus hupehensis (Pamp.) Rehd. T R 76.5 Scorzorera hipanica T R 25.7 Malus sp. T R 39.8 Scuttellaria lateriflora T S 41.2 Malus sp. T R 45.7 Setaria italica T S 33.4 Maiva noSchata T S 22.8 Solidago Canadensis T S 78.5 Malva Sylvestris T O 57.6 Stachys affinis T S 1OO.O Matteucia pensylvanica T R 20.1 Stachys byzantina T O 1OO.O Melissa officinalis T O 55.0 Stellaria media (linne)Cyrillo T O 51.2 Mentha piperita T R 35.5 Tanacetum vulgare T R 30.5 Mentha piperita T O 43.9 Tepary T R 31.7 Mentha piperita T R 56.6 Tepary T O 39.7 Mentha pullegium T O 33.3 Thymus Serpyllum T O 29.9 Mentha pullegium T R 56.2 Thymus Serpyllum T R 32.8 Mentha Spicata T O 43.4 Thymus X citriodorus T S 22.1 Mentha Spicata T O 58.0 Tiarella cordifolia T R 46.8 US 2004/0175439 A1 Sep. 9, 2004 32

TABLE 3-continued TABLE 4-continued

MMP-3 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Tragopogon porrifolium T R 26.3 Agrostis Stofonifera A. R 35.4 Tragopogon porrifolium T R 29.8 Alcea rosea A. S 45.8 Tragopogon porrifolium T O 58.0 Alkanna tinctoria A. S 42.5 Triticale sp. T O 25.3 Allium cepa A. O 49.7 Tropaedium nails T O 46.9 Allium grande A. R 71.4 Tropaedium nails T O 55.8 Allium porrum A. S 28.0 Tropaedium nails T R 64.7 Allium porrum A. O 82.O TSuga canOadensis T R 39.2 Allium Sativum A. S 23.7 Vaccinium angustifolium T R 28.0 Allium Schoenopra Sun A. O 45.5 Vaccinium angustifolium T S 29.6 Allium tuberoSun A. V 2O. Vaccinium angustifolium T R 33.3 Allium TuberoSun A. O 91.5 Vaccinium angustifolium Ait T R 1OO.O Althaea officinalis A. S 29.6 Vaccinium macrocarpon T S 25.1 Anaranthus gangeticus A. O 25. Vaccinium macrocarpon T R 27.4 Anaranthus gangeticus A. R 31. Vaccinium macrocarpon T O 35.4 Anaranthus gangeticus A. S 73.2 Populus X petrowskyana T R 66.7 Amaranthus retroflexus A. S 20.4 Prunus cerasifera T O 26.1 Ambrosia artemisiifolia A. R 50. Prunus cerasifera T R 64.2 Anelanchier Sanguinea A. W 37.6 Psidium guajaba T S 22.9 Anthenis nobilis A. O 40.4 Ptaridium aquilinus T R 43.O Anthenis nobilis A. R 66.7 Pyrus pyrifolia T S 28.2 Anthenis tinctorium A. S 30.3 Rahminus franguia T R 25.9 Apium graveolens A. R 71.2 Raphanus Sativus T R 21.4 Arachis hypogaea A. V 23.5 Raphanus Sativus T O 36.9 Aralia cordata A. S 21.2 Rhamnus franguia T O 43.2 Aralia cordata A. S 56.3 Rheum rhabarbarium T O 28.5 Arctium minius A. R 31.1 Rheum X cultorum T R 28.2 ArctostaphyloS uva-ursi A. S 31.2 Rianus communis T S 32.4 ArctostaphyloS uva-ursi A. O 31.2 Ribes nidigrolaria T S 28.5 Arctostaphylos uva-ursi A. R 59.7 Ribes nigrum T R 49.9 Arnoracia rusticana A. W 25.1 Rosa rugosa T S 29.1 Arnoracia rusticana A. S 56.2 Weigela hortensis T R 54.9 Aronia melanocarpa A. S 26.8 Zea mayS T O 74.3 Aronia melanocarpa A. S 41.3 Vaccinium macrocarpon T R 80.5 Aronia melanocarpa A. O 44.8 Vaccinium macrocarpon T O 90.5 Aronia melanocarpa A. W 47.7 Valeriana officinalis T O 33.O Aronia melanocarpa A. R 55.7 Veratrun wide T S 46.8 Aronia melanocarpa A. V 1OO.O Verbascum thapsus T O 33.4 Arrhenatherun elatius A. R 40.4 Vicia faba T R 26.6 Artemisia dracunculus A. S 51.1 Vicia faba T O 35.8 Asparagus Officinalis A. S 2O.9 Vigna angularia T S 29.3 Asparagus Officinalis A. S 32.6 Vigna angularia T O 54.O Aster sp A. O 29.5 Vigna Sesquipedalis T O 1OO.O Aster sp A. R 8O.O Vigna unguiculata T S 49.5 Atropa belladonna A. S 47.4 Vitia sp. T O 99.6 Beta vulgaris A. S 25.3 Vitis sp T R 50.9 Beta vulgaris A. R 26.6 Vitis sp. T R 75.8 Beta vulgaris A. W 34.O Weigela coracensis T S 22.8 its C. A 2. Weigela coracensis T S 22.8 Brassica napus A. R 53.1 Brassica napus A. O 1OO.O Brassica nigra A. S 24.2 Brassica oleracea A. R 33.O 0148 Brassica oleracea A. R 36.0 Brassica oleracea A. W 36.2 TABLE 4 Brassica oleracea A. S 73.1 Brassica Oileracea A. O 1OO.O MMP-9 Brassica rapa A. R 31.0 Brassica rapa A. W 38.6 Nom latin Stress Extrait Inhibition (%) Brassica rapa A. V 42.8 Brassica rapa A. R 48.8 Abelnochus esculentus A. S 26.8 Brassica rapa A. S 68.2 Achillea millefolium A. S 41.6 Brassica rapa A. O 89.2 Aconium napeius A. O 47.7 Bronius inermis A. R 51.4 Acorus Caianus A. O 83.2 Campanula rapunculus A. O 25.1 Actinidia arguta A. S 26.8 Canna edulis A. S 31.1 Adiantum pedatun A. O 20.7 Canna edulis A. O 47.6 Agastache foeniculum A. S 1OO.O Canna edulis A. R 68.9 Agrinonia eupatoria A. W 21.4 CapSella bursa-pastoris A. R 32.5 Agropyron cristatun A. R 51.4 Capsicum annuum A. O 22.0 Agropyron repenS A. S 27.3 Capsicum annuum A. R 24.0 AgroStis aiba A. R 40.6 capsicum annuum A. S 55.7 US 2004/0175439 A1 Sep. 9, 2004 33

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Capsicum frutescens A. S 30.3 Giechona hederacea A. S 37.6 Capsicum frutescens A. O 34.7 Glycine max A. R 38.1 Carthanus tinctorius A. R 28.5 Glycine Max A. O 56.4 Carium carvi A. S 38.6 Glycine max A. S 71.4 Chelidonium maius A. O 27.9 Glycyrrhiza glabra A. S 62.6 Chenopodium bonus-henricus A. R 47.4 Glycyrrhiza glabra A. W 1OO.O Chenopodium bonus-henricus A. O 20.7 Guizotia abyssinica A. R 91.9 Chenopodium bonus-henricus A. W 23.2 Hamamelis virginiana A. S 41.O Chenopodium bonus-henricus A. S 62.8 Hamamelis virginiana A. R 74.6 Chenopodium quinoa A. V 23. Hedeoma pullegioides A. O 22.0 Chenopodium quinoa A. W 34.7 Helianthus tuberosus A. W 21.2 Chrysanthemum leucanthemum A. O 20.6 Helianthus tuberosus A. W 51.5 Chrysanthemum leucanthemum A. R 30.9 Helichrysum angustifolium A. V 21.0 Chrysanthemun coronarium A. R 26.4 Heliotropium arborescens A. S 54.1 (Chip Suey) Helleborus niger A. S 37.8 Chrysanthenum coronarium A. S 66.6 Hordeum hexastichon A. W 38.0 Cichorium intybus A. S 44.7 HySSopus officinalis A. O 25.1 Citrulius ianatus A. S 62. Inula helenium A. S 29.7 Citrulius ianatus A. O 70.6 Satistinctoria A. S 41.5 Cornus Canadensis A. S 48.5 Lactuca Seria A. R 41.3 CoSnoS Sulphureus A. S 23.4 Lactuca Serrioia A. S 46.6 CoSnoS Sulphureus A. O 37.O Laportea Canadensis A. S 26.3 Crataegus sp A. V 32.4 Lathyrus Sativus A. O 22.2 Crataegus sp A. S 45.5 Lathyrus Sativus A. R 50.2 Crataegus sp A. R 1OO.O Lathyrus Sylvestris A. V 31.3 Crataegu.S. Subnois A. S 45.5 Lathyrus Sylvestris A. W 31.8 Cryptotaenia Canadensis A. W 26.4 Laurus nobilis A. S 25.7 Cucunnis Anguria A. R 27.2 Curburbita pepo A. R 41.O Cucumis anguria A. S 36.6 Curburbita pepo A. S 43.9 Cucunnis anguria A. O 38.5 Curcuna zedoaria A. S 67.6 Cucunnis meio A. O 59.2 Levisticum officinale A. O 44.9 Cucunnis Sativus A. R 39.8 Linaria vulgaris miller A. O 23.6 Cucunnis Sativus A. O 49.4 Linum usitatis.Simum A. R 33.3 Cucunnis Sativus A. S 54.4 Lolium multiflorum A. S 29.0 Cucurbita Maxina A. O 46.7 Lolium perenne A. R 52.0 Cucurbita noSchata A. S 32.1 Lotus corniculatus A. R 62.9 Cucurbita pepo A. O 37.O Lotus tetragonolobus A. S 62.9 Beta vulgaris spp. Maritima A. R 44.0 Lycopersicon eSculentum A. S 26. Beta vulgaris var. Condiwata A. R 35.4 Lycopersicon eSculentum A. W 33.O Brassica napus A. S 24.6 Maiva noSchata A. S 31.8 Curcurbita maxina A. S 25.8 Malva Sylvestris A. S 21.4 Cymbopogon citratus A. O 26.7 Maiva verticiliata A. R 43.4 Dactylis glomerata A. R 27.2 Matteucia pensylvanica A. R 26.9 Datisca cannabina A. S 26.9 Medicago Sativa A. V 20.4 Datisca cannabina A. O 38.0 Melilotus albus A. R 53.9 Daucus carota A. R 30.8 Melissa officinalis A. S 21.4 Daucus carota A. O 31.9 Melissa officinalis A. O 36.8 Dirca palustris A. O 27.3 Melissa officinalis A. R 53.7 Dirca palustris A. S 34.2 Mentha piperita A. S 57.7 Dolicos Labiab A. S 22.O Mentha pullegium A. S 66. Dolicos Labiab A. R 25.3 Mentha Spicata A. S 67.7 Dryopteris filix-mas A. S 24.9 Mentha Suaveolens A. S 51.8 Dryopteris filix-mas A. R 40.6 Monnordica charantia A. R 29.7 Eleusine Coracana A. S 2O2 Monnordica charantia A. S 72. Eleusine Coracana A. R 2O.9 Nicotiana rustica A. O 30.3 Eleusine Coracana A. O 71.1 Nicotiana rustica A. S 59. Elymus iunceus A. R 45.4 Nicotiana tabacunn A. S 39.0 Erigeron Canadensis A. S 35.7 Nicotiana tabacunn A. W 47.6 Eruca weSicaria A. R 59.9 Nicotiana tabacunn A. O 1OO.O Fagopyrun eSculentum A. V 20.7 Nigella Sativa A. R 59.4 Fagopyrun tartaricum A. W 30.3 Oenothera biennis A. O 21.3 Fagopyrun tartaricum A. O 33.2 Oenothera biennis A. O 36.7 Festuca rubra A. R 31.8 Origanum vulgare A. W 21.3 Foeniculum Vulgare A. W 27.4 Origanum vulgare A. V 42.7 Foeniculum vulgare A. O 50.6 Oryza Sativa A. W 56.5 Forsythia intermedia A. O 1OO.O Oxyria digyna A. W 35.1 Fragaria x ananassa A. V 3O.O Oxyria digyna A. V 76.4 Fragaria x ananassa A. S 36.3 Pastinaca Satiya A. V 20.3 Galium odoratum A. R 26.9 Pastinaca Satiya A. W 23.2 Gaultheria hispidula A. R 28.4 Pastinaca Satiya A. O 42.1 Gaultheria hispidula A. S 40.7 Pastinaca Satiya A. R 46.9 Gentiana lutea A. R 34.7 Phaiaris canariensis A. R 20.3 US 2004/0175439 A1 Sep. 9, 2004 34

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Phaiaris canariensis 80.5 Ruta graveolens 27.1 Phaseolus nungo 51.3 Salix purpurea 22.1 Phaseolus nungo 74.1 Salix purpurea 33.8 Phaseolus vulgaris 23.O Saivia elegans 23.7 Phaseolus vulgaris 51.4 Salvia Officinalis 20.8 Phaseolus vulgaris 62.6 Salvia Officinalis 31.4 Phlox paniculata 41.O Saivia Sciarea 28.0 Physalis alkekengi 31.6 Poa compressa 22.4 Physalisixocarpa 45.2 Poa compressa 49.3 Physalis Ixocarpa 65.3 Poa pratensis 22.4 Physalis Pruinosa 87.3 Polygonum pensylvanicum 43.3 Phytolacca americana 49.6 Polygonum persicaria 21.6 Phytolacca americana 89.8 Sium Sisarium 32.6 Pimpinella anisum 1OO.O Sium Sisarium 42.7 Plantago Coronopus 48.3 Solarium dulcanara 43.3 Plantago Coronopus 89.3 Soianum dulcanara 48.6 Plantago major 21.8 Soianum melanoceraSun 21.3 Laurus nobilis 3O.O Soianum melongena 20.5 Lavandula latifolia 40.3 Soianum melongena 35.6 Leonurus cardiaca 27.0 Soianum melongena 49.4 Lepidium Sativum 4.1.8 Soianum melongena 65.2 Levisticum officinale 29.0 Solidago sp 32.7 Polygonum persicaria 38.5 Spinacia Oileracea 41.O Potentilla anSerina 26.3 Stachys affinis 22.5 Potentilla anSerina 31.2 Stachys affinis 43.9 Poterium Sanquisorba 29.2 Stachys affinis 92.0 Pteridium aquilinum 27.3 Symphytum officinale 28.0 Raphanus Sativus 22.7 Tanacetum cinerariifolium Raphanus Sativus 30.8 Tanacetum cinerariifolium Raphanus Sativus 40.2 Tanacetum vulgare Raphanus Sativus 71.5 Tanacetum vulgare Raphanus Sativus 1OO.O Teucrium chamaedrys Rheum rhabarbarium 21.3 Teucrium chamaedrys Rheum rhabarbarium 67.9 Thymus Serpyilum Rheum rhabarbarium 72.4 Thymus vulgaris Ribes nidigrolaria 32.6 Thymus x citriodorus 27. Ribes nidigrolaria 64.6 Tragopogon porrifolius Ribes nigrum 23.6 Tragopogon porrifolius Ribes nigrum 27.2 Trifolium hybridum Ribes nigrum 41.O Trifolium pannonicum Ribes nigrum 65.8 Trifolium repens Ribes Nigrum 1OO.O Trigonelia foenium graecum Ribes Saiivum 75.4 Triticum spelta Ribes Sylvestre 27.7 Triticum turgidium Ribes Sylvestre 1OO.O Typha latifolia ribes uva-crispa 24.4 Urtica dioica Ribes Uva-crispa 36.6 Urtica dioica Ricinius communis 21.6 Vaccinium Corymbosum Rosa rugosa 30.6 Vaccinium Corymbosum 64 Rosa rugosa 36.2 Vaccinium augustifolium 44. Rosa rugosa 39.3 Vaccinium macrocarpon RoSmarinus officinalis 27.2 Veratrun viride RoSmarinus officinalis 45.7 Veratrun viride Rubus allegheniensis 53.7 Verbascum thapsus Rubus Canadensis 27.0 Verbascum thapsus Rubus Canadensis 41.O Viburnum trilobum Rubus Canadensis 41.2 Vicia Satiya Rubus Canadensis 45.1 Vicia villosa Rubus idaeus 24.3 Vigna unguiculata Rubus idaeus 39.7 Vigna unguiculata Rubus idaeus 62.2 Vigna unguiculata Rubus ideaus 37.O Vinca minor Runnex acetoSella 75.8 Vitis sp. Rumex acotosa 25.5 Vitis sp. Rumex crispus 73.3 Vitis sp. Rumex crispus 60.5 Xanthium Sibiricum Rumex patientia 49.4 Zea mayS Rumex patientia 65.8 Zea mayS Runnex Sciutatus 25.5 Zea Mays Runnex Sciutatus 61.9 Satureia montana Runnex Sciutatus 93.8 Scuttellaria lateriflora Ruta graveolens 25.8 Secale cereale US 2004/0175439 A1 Sep. 9, 2004 35

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Secale cereale 22.9 Campanula rapunculus 59.9 Secale cereale 26.9 Canna edulis 20.8 Sesamun indicum 21.2 Canna edulis 83.1 Setaria italica 27.0 Capsicum annuum 2O2 Adiantum pedatun 31.7 Capsicum annuum 29.6 Ageratun Conyzoides 23. Capsicum annuum 51.5 Agropyron cristatun 64. Capsicum annuum 60.8 Agropyron repenS 29.2 Capsicum fruitesCens 32.8 Agropyron repenS 32.6 Carthamus tinctorius 29.8 Agrostis Stolonifera 34.4 Carium carvi 30.4 Alcea rosea 22.7 Chelidonium maius 39.9 Alchemilia mollis 30.5 Chenopodium bonus-henricus 63.O Alchemilia mollis 33.2 Chenopodium quinoa 34.1 Allium anpeiopraSun 53.4 Chenopodium quinoa 42.8 Allium cepa 22.5 Chenopodium quinoa 46.1 Allium cepa 6O.7 Chichorium endivia subspendivia 22.0 Allium SchoenopraSun 21. Chichorium endivia subspendivia 22.9 Allium SchoenopraSun 60.4 Chrysanthemum coronarium 23.2 Allium tuberoSun 38.8 Chrysanthemum coronarium 68.4 Allium tuberoSun 74.4 Chrysanthemum leucanthemum 20.5 Althaea officianalis 54.9 Cicer arietinium 25.7 Anaranthus candathus 42.6 Cichorium intybus 51.1 Anaranthus caudathus 27. Cichorium intybus 53.4 Anaranthus gangeticus 56.8 Citrulius ianatus 36.5 Anaranthus gangeticus 74.4 Citrulius ianatus 71.5 Ambrosia artemisiifolia 49.O Coix Lacryma-Jobi 21.0 Anelanchier Sanguinea 45.2 Conus Canadensis 34.8 Angelica archangelica 2O.9 Crataegus sp 54.O Anthenis nobilis 58.9 Crataegus Submolis 31.3 Apium graveolens 30.4 Cryptotaenia Canadensis 32.1 Apium graveolens 36.4 Cucumis anguria 27.3 Apium graveolens 60.6 Cucumis anguria 32.5 Arachis hypogaea 26.O Cucunnis Sativu.S. 39.4 Aralia cordata 66.O Cucunnis Sativu.S. 69.4 Arctium minus 26.6 Cucurbita maxina 34.1 Arctium minus 30.8 Cucurbita maxina 42.6 ArctostaphyloS uva-ursi 29.3 Cucurbita noSchata 32.O ArctostaphyloS uva-ursi 38.8 Cucurbita noSchata 39.2 ArctostaphyloS uva-ursi 80.2 Cucurbita pepo 28.8 Arnoracia rusticana 62.7 Cucurbita pepo 32.6 Aronia melanocarpa 26.7 Curcuna zedoaria 23.3 Aronia melanocarpa 1OO.O Curcuna zedoaria 57.6 Aronia melanocarpa 1OO.O Cymbopogon citratus 70.1 Aronia melanocarpa (Michx.) Ell. 39.1 Cynara Scolynus 2O2 Artemisia dracunculus 44.3 Cynara Scolynus 37.5 Artemisia dracunculus 65.4 Cynara Scolynus 88.7 Asclepias incarnata 20.3 Cyperus esculentius 66.7 Asparagus Officinalis 22.3 Datura metel 29.2 Asparagus Officinalis 26.6 Datura Stranonium 27.6 Asparagus Officinalis 28.7 Brassica iuncea 45.O Aster sp 34.3 Brassica iuncea 66.1 Aster sp 62.6 Brassica Napus 27.5 Atropa belladonna 34.9 Brassica Napus 37.6 Beta vulgaris 28.3 Brassica napus 94.8 Beta vulgaris 42.2 Brassica nigra 36.4 Beta vulgaris 47.C Brassica oleracea 38.7 Beta vulgaris spp. Maritima 46.7 Brassica oleracea 39.0 Brassica cepticepa 26.7 Brassica oleracea 49.4 Brassica cepticepa 68.3 Echinochloa frumentacea 68.4 Achillea millefolium 45.5 Eleusine Coracana 47.8 Aconitun napeius 24.O Elymus iunceus 42.7 Aconitun napeius 53.9 Erigeron Canadensis 37.8 Acorus Caianus 87.6 Erigeron Speciosus 34.6 Acorus Caianus 1OO.O Errhenatherunn elatius 34.4 Actinidia arguta 33.8 Fagopyrun tartaricum 31.4 Adiantum pedatun 31.6 Foeniculum vulgare 28.0 Brassica oleracea 76.1 Foeniculum vulgare 44.6 Brassica oleracea 1OO.O Foeniculum vulgare 68.9 Brassica rapa 21.1 Foeniculum Vulgare 1OO.O Brassica rapa 64.O Forsythia intermedia 1OO.O Brassica rapa 1OO.O Forsythia x intermedia 79.5 Bronius inermis 36.7 Galium odoratum 32.4 US 2004/0175439 A1 Sep. 9, 2004 36

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Galium odoratum 1OO.O Nicotiana tabacunn 1OO.O Gaultheria hispidula 48.4 Nigella Sativa 24.2 Gaultheria hispidula 80.4 Ocinum basilicum 30.6 Gaultheria hispidula 1OO.O Oenothera biennis 48.0 Gaultheria procumbens 26.9 Oenothera biennis 76.6 Gaultheria procumbens 543 Origanum vulgare 41.3 Giechona hederacea 26.6 Oryza Saliva 22.1 Glycine max 52.5 Oxyria digyna 26.5 Glycine max 67.9 Oxyria digyna 70.3 Glycine max 75.8 Panicum miliaceum 94.4 Glycyrrhiza glabra 21.4 Pastinaca Satiya 29.4 Glycyrrhiza glabra 21.6 Pastinaca Satiya 79.2 Glycyrrhiza glabra 1OO.O Pennisetum alopecuroides 22.0 Guizotia abyssinica 91.4 Petasites japonicus 29.2 Hamamelis virginiana 39.8 Peucedanum Oreaselinum 21.3 Hamamelis virginiana 78.8 Phacelia tanacetifolia 23.5 Hamamelis virginiana 96.6 Phaiaris arundinacea 47.5 Hedeoma pullegioides 45.4 Phaiaris canariensis 23.1 Helenium hoopesii 22.6 Phaiaris canariensis 1OO.O Helenium hoopesii 52.8 Phaseolus coccineus 37.O Helianthus annuus 22.O Phaseolus coccineus 74.1 Helianthus annuus Phaseolus nungo 42.2 Helianthus Strunosus Phaseolus nungo 52.2 Helianthus Strunosus Phaseolus vulgaris 35.5 Helianthus tuberosus Phaseolus vulgaris 48.0 Helianthus tuberosus OO Phaseolus vulgaris 58.1 Helianthus tuberosus L Phlox paniculata 32.2 Heliotropium arborescens Phlox paniculata 40.1 Heliotropium arborescens Physalis ixocarpa 20.6 Helleborus niger Lachica Serroia 53.0 Hordeum vulgare Lactuca Sativa 24.5 Huniulus lupulus Laportea Canadensis 36.0 Hypericum sp Laportea Canadensis 81.7 HySSopus officinalis Lathyrus Sativus 37.8 Iberis anara Lathyrus Sylvestris 40.7 Iberis anara Lathyrus Sylvestris 79.1 Inula helenium Laurus nobilis 22.7 Ipomoea batatas 3 Lavandula angustifolia 31.7 Satistinctoria Lavandula latifolia 27.2 Daucus carota s 2 Ledum groenlandicum 61.1 Daucus carota Poa compressa 22.1 Dipsacus Sativus i 3 Poa compressa 45.5 Dirca palustris 29. Poa pratensis 35.7 Dirca palustris 36.4 Polygonum pensylvanicum 38.3 DolichoS Labiab 35.8 Polygonum persicaria 31.0 DolichoS Labiab 74.5 Potentilla anSerina 46.8 Dryopteris filix-mas 27.9 Poterium Sanquisorba 24.7 Dryopteris filix-mas 42.6 Poterium Sanquisorba 30.6 Leonurus cardiaca 22.6 Prunus cerasifera 45.9 Lepidium Sativum 23.3 Pteridium aquilinum 22.4 Levisticum officinale 23.1 Raphanus Raphanistrum 36.5 Levisticum officinale 27.5 Raphanus Raphanistrum 75.0 Levisticum officinale 41.3 Raphanus Sativus 20.8 Linum usitatis.Simum 21.4 Raphanus Sativus 27.5 Lolium perenne 32.7 Raphanus Sativus 35.4 Lotus corniculatus 54.2 Rheum rhabarbarium 27.0 Maius hupehensis 26.4 Ribes GroSSularia 33.7 Maiva verticiliata 37.9 Ribes nidigrolaria 3O.7 Matricaria reciutita 50.3 Ribes nidigrolaria 40.5 Medicago Sativa 29.1 Ribes nigrum 35.9 Melilotus albus 52.1 Ribes nigrum 58.6 Melissa officinalis 22.7 Ribes SilveStris 26.9 Melissa officinalis 35.9 Ribes SilveStris 1OO.O Melissa officinalis 38.6 Ricinius communis 21.8 Mentha piperita 64.4 RoSmarinus officinalis 24.7 Mentha Suaveolens 22.5 RoSmarinus officinalis 30.9 Monnordica charantia 29.3 RoSmarinus officinalis 60.3 Monnordica charantia 90.6 Rubus ideaus 32.5 Nepeta cataria 50.5 Rubus ideaus 47.O Nicotiana rustica 35.3 Rubus occidentalis 39.4 Nicotiana rustica 1OO.O Rubus occidentalis 74.1 Nicotiana tabacunn 31.6 Rumex acetosa 45.6 US 2004/0175439 A1 Sep. 9, 2004 37

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Runnex acetoSella 22.8 Tropaeoium nails 76.1 Runnex acetoSella 31.5 Typha latifolia 43.3 Rumex crispus 25.S Urtica dioica 40.3 Rumex crispus 70.3 Vaccinium angustifolium 42.4 Rumex patientia 39.8 Vaccinium corymbosum 61.5 Rumex patientia 54.2 Vaccinium macrocarpon 43.7 Rumex Sciutatus 23.8 Vaccinium angustifolium 23.1 Rumex Sciutatus 69.9 Veratrun viride 43.6 Rumex Sciutatus 78.8 Verbascum thapsus 37.8 Ruta graveolens 3O.7 Santolina Chamaecyparissus 25.2 Ruta graveolens 61.5 Satureia montana 21.2 Saivia elagens 25.4 Scuttellaria lateriflora 37.O Saivia elegans 31.1 Secale cereale 26.7 Sambucus Canadensis 80.6 Secale cereale 27.3 Sambucus ebulus 26.1 Serratula tinctoria 38.2 Sambucus ebulus 34.4 Serratula tinctoria 70.3 Sambucus ebulus 37.8 Sesamun indicum 27.6 Sanguisorba Officinalis 1OO.O Sesamun Indicum 44.3 Santolina Chamaecyparissus 21.7 Silybum marianum 34.7 Physalis pruinosa 8O.O Sium Sisarun 79.0 Phytolacca americana 62.O Soianum dulcanara 25.2 Phytolacca americana 1OO.O Soianum dulcanara 64.6 Pimpinella anisum 37.3 Vinca minor 33.6 Pisun Sativium 34.4 Vinca minor 34.3 Pisun Sativium 6.3.3 Vitis sp. 29.0 Plantago Coronopus 42.7 Vitis sp. 50.2 Plantago Coronopus 46.4 Vitis sp. 53.3 Plantago major 28.3 Vitis sp. 63.O Plantago major 41.4 Vitis sp. 86.6 Plectranthus sp. 29.3 Withania Sonnifera 20.3 Solarium melongena 36.6 Xanthium Sibiricum 34.7 Soianum melongena 40.1 Xanthium Strunnarium 23.2 Soianum melongena SO.O Zea mayS 20.1 Soianum melongena 74.9 Zea mayS 45.9 Soianum tuberosum 39.1 Zea mayS 97.5 Soianum tuberosum 39.2 Abelnochus esculentus 24.8 Solidago sp 3O.7 Abies lasiocarpa 44.7 Sorghum caffronun 87.9 Achillea millefolium 24.1 Sorghum dochna 20.6 Achillea millefolium 59.2 Sorghum dochna 20.6 Aconitum napeius 40.6 Sorghum dochna 34.1 Aconitum napeius 41.6 Sorghum dochna 97.0 Acorus Caianus 47.1 Sorghum durra 30.6 Actinidia arguta 21.8 Sorghun durira 30.6 Adiantum pedatun 26.8 Sorghun durira 48.0 Adiantum pedatun 45.8 Sorghum Sudanense 21.7 Adiantum pedatun 86.0 Sorghum Sudanense 24.6 Agaricus bisporus 26.3 Sorghum Sudanense 32.1 Agaricus bisporus 29.8 Spinacia oleracea 53.2 Agaricus bisporus 36.9 Stachys Affinis 25.0 Agaricus bisporus 44.0 Stachys Affinis 27.8 Agaricus bisporus 46.0 Stachys Affinis 1OO.O Agastache foeniculum 7O.O Symphytum officinale 21.7 Ageratum conyzoides 31.7 Symphytum officinale 25.2 Agropyron cristatun 86.9 Symphytum officinale 34.6 Agropyron repenS 49.6 Tanacetum cinerariifolium 52.4 Agrostis aiba 21.9 Tanacetum vulgare 27.1 Agrostis Stolonifera 35.8 Tanacetum vulgare 72.7 Alcea rosea 35.2 Teucrium chamaedrys 24.6 Alchemilia mollis 37.9 Teucrium chamaedrys 52.8 Allium anpeiopraSun 48.0 Thymus fragantissuinus 1OO.O Allium ascaionicum 26.2 Thymus vulgaris 24.2 Allium ascaionicum 77.2 Thymus x citriodorus 23.7 Allium cepa 92.6 Tiarella cordifolia 20.8 Allium grande 60.4 Tiarella cordifolia 30.8 Allium SchoenoporaSun 65.8 Tragopogon porrifolius 22.8 Allium Schoenopra Sun 31.0 Trifolium hybridum 24.7 Allium tuberoSun 22.8 Trifolium pannonicum 65.5 Allium tuberoSun 99.7 Trifolium repens 57.5 Althaea officianalis 22.8 Trigonelia foenungraecum 37.6 Althaea officinalis 22.1 Triticum furgidium 56.5 Anaranthus candathus 43.9 Triticum spelta 40.8 Verbascum thapsus 87.O US 2004/0175439 A1 Sep. 9, 2004 38

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Veronica officinalis G S 30.5 Anthenis nobilis T R 72.8 Viburnum trilobum G S 49.4 Anthenis tinctorium T S 27.3 Viburnum trilobum G R 1OO.O Anthemis cerefolium T W 35.8 Viburnum trilobum G V 1OO.O Apium graveolens T S 31.7 Vicia faba G R 50.5 Brassica rapa T R 33.9 Vicia Satiya G R 42.4 Brassica rapa T R 56.O Vicia villosa G R 89.2 Brassica rapa T S 69.7 Vigna angularia G R 28.1 Brassica rapa T O 1OO.O Vigna angularia G S 71.5 Bronius inermis T R 57.3 Vigna unguiculata G R 21.0 Campanula rapunculus T O 77.5 Vigna unguiculata G O 38.7 Canna edulis T O 75.6 Vigna unguiculata G S 61.1 Canthareilus ciparium T O 52.5 Apium graveolens T W 32.4 CapSella bursa-pastoris T O 35.9 Apium graveolens T R 56.6 Capsicum annus T S 43.9 Aralia cordata T R 29.2 Capsicum annuum T S 50. Aralia cordata T S 45.O Capsicum fruitesCens T S 28.9 Arctium minus T R 25.8 Carica papaya T W 31. ArctostaphyloS uva-ursi T O 31.O Carthamus tinctorius T R 37.3 ArctostaphyloS uva-ursi T S 35.2 Carium carvi T S 3O. ArctostaphyloS uva-ursi T R 58.6 Castanea spp. T W 21.7 Arnoracia rusticana T W 24.9 Chaerophyllum bulbosum T S 46.0 Arnoracia rusticana T S 52.9 Channaenelun nobile T W 36.8 Aronia melanocarpa T W 40.O Channaenelun nobile T W 48.4 Aronia melanocarpa T V 91.9 Chelidonium maius T O 46.6 Aronia prunifolia T W 1OO.O Chenapodium bonus-henricus T R 22.4 Arrhenatherun elatius T R 22.8 Chenopodium bonus-henricus T S 57.6 Artemisia draculus T S 74.9 Chenopodium quinoa T V 35.5 Artemisia dracunculus T S 47.8 Chenopodium quinoa T W 54.4 Asclepias incarnata T R 20.5 Chrysanthemum leucanthemum T R 26.5 ASctinidia chinensis T V 43.4 Chrysanthemun coronarium T R 48.4 ASctinidia chinensis T O 66.4 (Chip Suey) Asparagus Officinalis T O 91.3 Chrysanthenum coronarium T R 38.2 Asparagus Officinalis T R 23.3 Chrysanthenum coronarium T S 63.9 Asparagus Officinalis T S 44.7 Cicer arietinium T S 2O.O Aster Linné T S 47.5 Cichorium endivia T S 25.6 Aster sp T R 62.O Cichorium endivia crispa T O 38.4 Atriplex hortensis T R 54.6 Cichorium intybus T S 30.2 Atropa belladonna T R 20.1 Cinicifuga racenOSa T S 33.7 Atropa belladonna T S 51.O Citrullus colocynthus T S 20.4 Avena Sativa T R 24.8 Citrulius ianatus T O 68.3 Avena Sativa T W 26.4 Citrulius ianatus T S 31.9 Averrhoa caramboia T W 23.4 Citrus innettoides T W 20.4 Ayperus esculentius T S 46.2 Citrus innettoides T V 37.5 Beta vulgaris T R 28.2 Citrus innon T V 47.7 Beta vulgaris T S 30.4 Citrus innon T O 72.4 Beta vulgaris T O 56.8 Citrus paradisi T W 23.8 Beta vulgaris spp. Maritima T R 23.6 Citrus paradisi T V 33.4 Betula glandulosa T O 22.2 Citrus reticulata T V 20.4 Betula glandulosa T V 22.2 Citrus reticulata T V 2O.9 Betula glandulosa T S 25.7 Citrus reticulata T W 26.0 Betula glandulosa T W 32.9 Citrus reticulata T S 40.4 Boletus edulis T S 36.2 Citrus reticulata T O SO.O Boletus edulis T O 90.2 Citrus reticulata T O 79.2 Borago officinalis T S 27.9 Brassica Napus T S 22.0 Borago officinalis T O 76.1 Brassica Napus T R 34.O Brassica cepticepa T O 65.4 Brassica Napus T O 1OO.O Brassica cepticepa T S 71.5 Brassica nigra T S 26.7 Brassica Chineusis T R 27.1 Brassica nigra T O 27.4 Brassica iuncea T O 51.O Brassica nigra T R 82.5 Brassica iuncea T R 66.O Brassica oleracea T O 21.2 Brassica iuncea T S 74.1 Brassica oleracea T S 22.1 Anaranthus gangeticus T O 30.3 Brassica oleracea T W 26.2 Anaranthus gangeticus T S 66.O Brassica oleracea T R 27.2 Ambrosia artemisiifolia T R 58.7 Brassica oleracea T O 31.3 Anelanchier alnitolia T R 70.5 Brassica oleracea T W 46.5 Anelanchier Sanguinea T W 37.3 Brassica oleracea T S 71.2 Ananas COmoSuS T W 23.8 Brassica oleracea T O 93.5 Ananas COmoSuS T V 95.0 Brassica rapa T R 25.6 Ananas COmoSuS T O 99.6 Cucunnis melo T O 46.2 angelica archangelica T S 30.5 Cucumis metuliferus T W 32.O angelica archangelica T R 38.9 Cucumis Sativus Fanfare T O 40.3 Anthenis nobilis T O 41.4 Cucurbita maxina T S 23.6 US 2004/0175439 A1 Sep. 9, 2004 39

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Cucurbita maxina 33.1 Helichrysum angustifolium 67.O Cucurbita maxina 55.2 Heliotropium arborescens 58.9 Cucurbita noSchata 20.1 Helleborus niger 31.9 Cucurbita noSchata 26.7 Hibiscus cannabinus 48.9 Cucurbita noSchata 4 7 Hordeum vulgare 29.2 Cucurbita pepo Huniulus lupulus 22.4 Cucurbita pepo Huniulus lupulus 39.1 Curcuna zedoaria Huniulus lupulus 63.1 Cydonia oblonga Huniulus lupulus 1OO.O Cynara Scolynus Hydrastis canadensis 2O2 Cynara Scolynus Hydrastis canadensis 31.0 Dactilis Gionerata HyOScyanus niger 56.8 Datura Stranonium Hypericum henryi 48.8 Daucus carota Hypericum perforatum 48.1 DioScorea batatas Hypericum perforatum 63.7 DioScorea batatas Hypomyces lactiflorum 44.8 DioSpiros Kaki 34 Hypomyces lactiflorum 60.9 Dirca palustris Hyssops officinalis 22.9 Dirca palustris Inula helenium 24.6 Dolichus labiab Juniperus communis 33.O Dolichus labiab Juniperus communis 38.2 Dryopteris filix-mas Lactuca Sativa 44.5 Dryopteris filix-mas Lactuca Sativa 50.7 Echinacea purpurea Laportea Canadensis 30.2 Eleusine Coracana Lathyrus Sativus 20.4 Elymus iunceus Lathyrus Sativus 52.5 Erigeron Canadensis Lathyrus Sylvestris 27.7 Eriobotrya japonica Lathyrus Sylvestris 36.8 Eruca weSicaria 44 9 Laurus nobilis 52.0 Fagopyrun eSculentum Lavendula angustifolia 26.4 Fagopyrun tartaricum Lavendula angustifolia 53.2 Festuca rubra Lavendula latifolia 51.3 Festuca rubra Ledum groenlandicum 44.4 Foeniculum vulgare Lentinus edodes 42.1 Foericulum vulgare Fragaria x ananassa 29.3 Foericulum vulgare Galium odoratum 26.C Forsythia intermedia Gaultheria hispidula 40.3 Forsythia x intermedia Ginkgo biloba 27.C Fortunella spp Ginkgo biloba 68.9 Fortunella spp Giechona hederacea 20.4 Fortunella spp Giechona hederacea 30.4 Fragaria Glycine max 26.6 Fragaria Glycine max 47.4 Fragaria Glycine max 82.O Citrus Sinensis Glycyrrhiza glabra 35.4 Citrus Sinensis Glycyrrhiza glabra 40.5 Coix Lacryma-Jobi Glycyrrhiza glabra 1OO.O Conchorus oitorius Gossypium herbaceum 36. Cornus Canadensis Guizotia abyssinica 28.9 CoSnoS Sulphureus Guizotia abyssinica 40.4 Crataegus sp Maius 44.4 Crataegus sp Malus hupehensis (Pamp.) Rehd. 26.3 Crataegu.S. Subnois Malus hupehensis (Pamp.) Rehd. 67.O Crithmun maritina Malus sp. 65.3 Cryptotaenia Canadensis Maiva noSchata 41. Cryptotaenia Canadensis Malva Sylvestris 36.4 Cryptotaenia Canadensis Malva Sylvestris 47.4 Cucunnis anguria Maiva verticiliata 42.7 Cucunnis anguria Mangifera indica 30.5 Cucunnis meio Manihot esculenta syn. 38.3 Hamamelis virginiana M. utilissina Hamamelis virginiana Manihot esculenta syn. T S SO.4 Hamamelis virginiana M. utilissina Hedeona pullegiodes Manihot esculenta syn. T O 86.5 Helenium hoopesii M. utilissina Helenium hoopesii Melilotus aba 30.4 Helianthus annus Melilotus officinalis 68.1 Helianthus Strunosus Melissa officinalis 33.7 Helianthus Strunosus Melissa officinalis 34.7 Helianthus tuberosa mentha arvensis 53.7 Helianthus tuberosus L Mentha Suaveolens 26.8 Helianthus tuberosus L Menyanthes trifoliata 32.8 US 2004/0175439 A1 Sep. 9, 2004 40

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Miscanthus Sinensis Andress 22.7 Plantago Coronopus 48.6 Monnordica charantia 55.5 Plantago Coronopus 66.8 Monarda didyma 26.8 Plantago major 35.1 Monarda fistulosa 21.5 Pleurotus spp 25.3 Montia perfoliata 26.6 Pleurotus spp 59.3 Musa paradisiaca 29.0 Pleurotus spp 85.2 nasturtium officinale 35.4 Poa compressa 26.2 Nepeta cataria 26.5 Poa pratensis 21.5 Nepeta cataria 27.5 Poa pratensis 3O.O Nepeta cataria 41.9 Podophyllum peltatum 33.9 Nephelium longana Ou 43.4 Podophyllum peltatum 50.2 Euphoria longana Polygonum aviculare linné 31.0 Nicotiana rustica 26.O Polygonum pennsylvanicum 56.6 Nicotiana rustica 32.7 Polygonum persicaria 20.1 Nicotiana tabacunn 25.1 populus incrassata 54.9 Nicotiana tabacunn 77.7 populus Trenitia 31.0 Nigella Sativa 59.3 Populus X petrowskyana 1OO.O Nigella Sativa 1OO.O Potentilla anSerina 22.1 Ocinum Basilicum 2O2 Potentilla anSerina 41.1 Ocinum Basilicum 2O2 Oxyria digyna 57.0 Ocinum Basilicum 32.8 Oxyria digyna 77.9 Oenothera biennis linné 1OO.O Panax quinquefolius L. 23.5 Onobrychis viciafolia 45.O Panicum miliaceum 36.5 Optunia sp. 33.4 Passiflora spp 35.8 Origanun nationara 20.5 Passiflora spp 38.3 Origanum vulgare 20.8 Passiflora spp 46.2 Origanum vulgare 21.6 Passiflora spp 1OO.O Oryza Sativa 42.4 Pastinaca Satiya 21.7 Lentinus edodes 1OO.O Pastinaca Satiya 38.6 Lepidium Sativum 44.2 Pastinaca Satiya 39.2 Levisticum officinale 20.8 PerSea annericana 32.5 Levisticum officinale 39.4 PerSea annericana 38.6 Linum usitatis.Simum 42.3 Petasites Japonicus 26.2 Litchi chinensis 25.7 Phaiaris canariensis 8O.O Lolium multiflorum 20.6 Phaseolus coccineus 44.4 Lolium perenne 28.7 Phaseolus coccineus 79.1 Lonicera ranosissina 26.3 Phaseolus nungo 27.0 Lonicera ranosissina 40.4 Raphanus Sativus 38.1 Lonicera ranosissina 53.2 Raphanus Sativus 63.6 Lonicera Syringantha 95.8 Raphanus Sativus 93.4 Lotus corniculatus 1OO.O Reseda luteola 22.5 Lotus tetragonoiubus 65.4 Rharninus frangula 34.2 Lunaria annua 55.7 Rhamnus franguia 39.5 Lunaria annua 67.3 Rheum officinale 1OO.O Lycopersicon eSculentum 37.6 Rheum palmatum 2O2 Malus 31.8 Rheum rhabarbarium 33.8 Phaseolus nungo 37.9 Rianits communis 2O.9 Phaseolus vulgaris 20.1 Ribes nidigrolaria 44.5 Phaseolus vulgaris 51.9 Ribes nidigrolaria 53.1 Phaseolus vulgaris 61.7 Ribes nigrum 40.7 Phlox paniculata 22.9 Ribes nigrum L SO.O Phlox paniculata 44.5 Ribes nigrum L 60.1 Phoenix dactylifera 29.6 Ribes sativam Syme 47.9 Physalis alkekengi 32.9 Ribes Sativum 48.2 Physalisixocarpa 26.6 Ribes SilveStre 26.3 Physalisixocarpa 28.3 Ribes SilveStre 1OOC Physalis pruinosa 27.3 Ribes uva-crispa 57.5 Physalis pruinosa 47.8 Rosa rugosa 27.8 Physalis pruinosa 93.1 Rosa rugOSa thunb. 37.5 Physalis sp 39.1 Rosa rugOSa thunb. 45.7 Physalis sp 60.8 RoSmarinum officinalis 44.2 Phytolacca americana 4.1.8 RoSmarinum officinalis 65.9 Phytolacca americana 1OO.O Rubus canadensis 45.5 Phytolacca decandra syn. 85.9 Rubus idaeus 31.4 Pannericana Rubus idaeus 57.2 Pimpinella anisum 2O2 Rubus ideaus 28.5 Pimpinella anisum 68.4 Rubus ideaus 38.0 Pisun Sativium 20.1 Rubus occidentalis 21.4 Pisun Sativium 25.8 Rubus occidentalis 36.5 Pisun Sativium 27.0 Rubus occidentalis 60.2 Pisun Sativium 51.8 RuneS Scutatus 84.5 Plantago Coronopus 21.9 Rumex crispus linné 52.5 US 2004/0175439 A1 Sep. 9, 2004 41

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9 Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Rumex crispus linné 1OO.O Tragopogon sp. 20.3 Rumex patientia 23. Tragopogon sp. 32.O Rumex patientia 65.8 Tragopogon sp. 66.3 Ruta graveolens 37.2 Sambucus Canadensis 72.4 Sabal Serrulata syn. 34.4 Sambucus Canadensis L 67.8 Serenoa repens Sambucus ebulus 44.3 Sabal Serrulata syn. T S 44.6 Sanguisorba Officinalis 1OO.O Serenoa repens Santolina 37.9 Salix purpurea 67.8 Satureia montana 2O.O Salvia (elegens) 51. Satureia montana 21.3 Sambucus Canadensis 44.8 Satureia repandra 36.3 Prunus ceraSils 3O. Scorzorera hipanica 27.1 Prunus persica 26.6 Scorzorera hipanica 31.7 Prunus persica 38.5 Scuttellaria lateriflora 44.3 Prunus spp 24.O Secale cereale 24.2 Prunus spp 49. Secale cereale 31.1 Psidium guajaba Sechium edule 37.8 Psidium guajaba Sesamun indicum 59.2 Psidium guajaba Setaria italica 33.O Psidium spp Silybum marianum 92.4 Psidium spp Sium Sisarun 32.7 Psidium spp Sium Sisarun 33.1 Pteridium aquilinum Sium Sisarun 813 Punica granatun Vaccinium angustfolium 34.6 Pyrus communis Vaccinium angustifolium 59.6 Pyrus pyrifolia Vaccinium angustifolium 65.7 Raphanus raphanistrum Vaccinium macrocarpon 30.2 Raphanus raphanistrum Vaccinium macrocarpon 39.0 Raphanus raphanistrum Vaccinium macrocarpon 56.9 Raphanus Sativus Vaccinium macrocarpon 39.2 Raphanus Sativus Vaccinium macrocarpon 42.3 Soianum melogena Veratrun viride 20.5 Soianum melogena Veratrun viride 33.1 Soianum melogena Verbascum thapsus 43.1 Soianum melogena Verbascum thapsus 70.2 Soianum Tilberosum Veronica officinalis 20.5 Solidago Canadensis Viburnum trilobum Marsh. 40.6 Solidago sp Vicia faba 61.5 Solidago virgaurea 5 Vicia Satiya 30.1 Sorghum caffronun Vigna angularia 32.6 Sorghum dochna bicolor gr Vigna angularia 64.2 technicum Vigna unguiculata 32.4 Sorghum dochna Snowdrew Vigna unguiculata 47.4 Sorghum dochna Snowdrew Vigna unguiculata 51.O Spinacia oleracea Vinca minor 21.3 Spinacia oleracea Vitis sp. 28.3 Spinacia oleracea Vitis sp. 29.4 Spinacia oleracea Vitis sp. 45.4 Stachys affinis Vitis sp. 50.7 Stachys affinis Vitis sp. 61.6 Stachys byzantina Vitis sp. 1OO.O Stipa capiliata L Weigela coracensis 35.5 Symphytum officinale Withania Sonnifera 35.5 Tanacetum cinerariifolium Xanthium Sibiricum 38.6 Tanacetum cinerariifolium 84.4 Xanthium Strunnarium 33.5 Tanacetum vulgare 25.7 Zea mayS 37.1 Tanacetum vulgare 75.6 Zea mayS 65.5 Taraxacum officinale (Red ribe) 21. Zingiber officinale 20.1 Tepary 56.7 Zingiber officinale 58.9 Teucrium chamaedrys L. 27.3 Zingiber officinale 75.9 Thalpsi arvense 61.4 TrichoSanthes kirillowii 66.5 Thymus fragantissuinus 1OO.O Trifolium incamatum 47.9 Thymus herba-barona 22.O Trifolium repens 81.7 Thymus pseudoianuginosus 36.8 Trigonelia foenium graecum 39.6 Thymus pseudoianuginosus 37. Triticale sp. 64.1 Thymus serpyllum 26.O Triticium aestivium 24.5 Thymus serpyllum 42.7 Triticium aestivium 29.4 Thymus X citriodorus 22.7 Triticum furgidiumn 35.8 Tiarella cordifolia 1OO.O Triticum spelta 34.7 Tragopogon porrifolius 26.8 Tropaeoium nails 90.3 Tragopogon porrifolius 28.4 Tropaeoium nails 20.1 Tragopogon porrifolius 42.1 TSuga canOadensis 21.5 US 2004/0175439 A1 Sep. 9, 2004 42

TABLE 4-continued TABLE 5-continued

MMP-9 Cath B Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) TSuga canOadensis T W 64.4 Brassica Oileracea A. O 27.5 Tsuga diversifolia T O 45.9 Brassica Oileracea A. O 48.2 Tsuga diversifolia T W 1OO.O Brassica rapa A. O 20.8 Tsuga F. macrophylla T W 28.1 Calendula officinalis A. O 35.6 Typha latifolia L T S 30.6 Camelia Sinensis syn. A. R 24.4 Urtica dioica T O 31.4 Thea sinensis Urtica dioica T R 36.9 Cana edulis A R 1OO.O Urtica dioica T S 41.7 Capsicum annuum A. O 25.0 Cichorium intybus A. R 1OO.O Vaccinium angustifolium T V 25.2 Citrulius ianatus A. O 24.4 Convailaria naialis A. O 57.0 Coriandrum Sativum A. R 20.8 Cryptotaenia Canadensis A. O 20.4 0149) Cucunnis Anguria A. O 26.8 Cucunnis Sativu.S. A. R 45.6 TABLE 5 Curburbita pepo A. O 30.8 Daucus Carota A. R 68.8 Cath B Daucus Carota A. O 20.3 Daucus Carota A. R 72.5 Nom latin Stress Extrait Inhibition (%) Daucus Carota A. O 22.6 Daucus Carota A. O 25.6 Achillea millefolium A. O 61.9 Daucus Carota A. R 65.9 Achillea tonnentosa A. O 60.8 Daucus Carota A. R 77.3 Aconitum A. O 38.6 Daucus Carota A. R 41.6 Aconitun napeius A. O 61. Dirca palustris A. R 1OO.O Alchemilia mollis A. R 26.7 Eruca weSicaria A. O 41.4 Allium A. R 43.0 Filipendula rubra A. R 65.O Allium cepa gr. Cepa A. O 49.9 Forsythia intermedia A. R 1OO.O Allium cepa gr. Cepa A. O 70. Forsythia x intermedia A. R 1OO.O Allium cepa gr. Cepa A. R 45.8 Geun rivale A. O 26.4 Allium Sativum A. O 25.6 Glycyrrhiza glabra A. R 86.8 Allium TuberoSun A. O 91.5 Heliotropium arborescens A. O 29.5 Allium TuberoSun A. O 75.0 Huniulus Lupulus A. O 65.4 Allium victorialis A. O 31. Huniulus Lupulus A. R 1OO.O Anaranthus gangeticus A. O 26. Hylotelephium A. R 23.7 Anaranthus gangeticus A. O 29.0 Hypericum henryi A. R 44.4 Anelanchier Canadensis A. R 28.7 Iberis Sempervirens A. O 846 Anthenis tinctoria A. O 26.8 Jeffersonia diphylla A. O 35.4 Anthenis tinctoria A. R 32.4 Ligularia dentata A. O 30.3 Anthoxanthun Odoratun A. O 24.9 Lonicera ranosissina A. R 48.7 Apium graveolens A. O 31. Miscanthus Saccharifiorus A. O 50.9 Apium graveolens A. O 20.6 Nicotiana tabacunn A. O 40.O Aralia cordata A. R 52.3 Nicotiana tabacunn A. O 56.8 Arctium lappa A. O 33.7 Nicotiana tabacunn A. O 55.2 Arctium lappa A. R 33.O Nigella Sativa A. O 40.3 Aronia melanocarpa (Michx.) Ell. A. R 41.2 Origanum majorana A. O 49.7 Aronia melanocarpa (Michx.) Ell. A. O 21.6 Origanum vulgare A. O 67.O Asarun europaeum A. O 24.9 Origanum vulgare A. O 39.9 Athaea officinalis A. O 57.7 Panax quinquefolius L. A. O 24.0 Athyrium asperun A. O 27.3 Pastinaca Satiya A. R 33.5 Atropa belladonna A. O 37.7 Petroselinum crispum A. O 70.2 Begonia convolvulacea A. O 26.0 Peucedanum cervaria A. O 21.5 Begonia emini A. O 34.2 Phaseolus Vulgaris A. O 67.9 Begonia glabra A. O 38.9 Philadelphus coronarius A. O 24.0 Begonia Hannii A. O 52.9 PhySOStegia virginiana A. O 56.9 Begonia polygonoides A. O 67.3 Phytolacca americana A. O 1OO.O Berberis vulgaris A. O 54.6 Plantago major A. O 31.2 Beta vulgaris A. R 39.9 Plectranthus fruticosus A. O 32.1 Beta vulgaris A. R 30.4 Polygonum pennsylvanicum A. R 70.1 Beta vulgaris A. O 61.9 Pulmonaria Saccharata A. O 31.1 Beta vulgaris A. O 43.0 Raphanus Sativus A. O 21.5 Beta vulgaris A. R 91.O Raphanus Sativus A. O 50.5 Beta vulgaris A. O 46.7 Beta vulgaris A. R 65.3 Raphanus Sativus A. O 58.8 Beta vulgaris A. R 33.4 Ribes nigrum L. A. O 53.1 Beta vulgaris A. O 54.3 Rubus Allegheniensis A. O 56.7 Beta vulgaris A. O 38.2 Rubus ideaus A. R 89.0 Beta vulgaris A. R 55.9 Capsicum fruitesCens A. O 29.6 Beta vulgaris A. R 28.5 Chrysanthemum balsamita A. O 89.3 Beta vulgaris A. O 40.1 Chrysanthemun balsamina A. O 65.O Beta vulgaris spp. Maritima A. O 33.4 Chrysanthemun coronarium A. O 30.1 Brassica iuncea A. O 21.3 (Chip Suey) US 2004/0175439 A1 Sep. 9, 2004 43

TABLE 5-continued TABLE 5-continued

Cath B Cath B Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Chrysanthemun coronarium A. O 36.4 Filipendula rubra G R 93.2 (Chip Suey) Filipendula rubra G R 1OO.O Saivia Sciarea A. O 21.5 Filipendula ulmaria G O 20.5 Saponaria Oficinalis A. O 68.5 Filipendula vulgaris G O 26.2 Satureia montana A. O 47.6 Forsythia intermedia G R 1OO.O Scorzonera hispanica A. O 29.9 Forsythia x intermedia G R 1OO.O Sesamun indicum A. O 84.8 Galium odoratum G O 21.0 Soianum dulcanara A. O 51.3 Gaultheria hispidula G R 39.3 Solidago Canadensis A. O 95.3 (L) Muhl Solidago hybrida A. O 94.5 Gaultheria procumbens G R 43.4 Solidago hybrida A. O 99.5 Geun rivale G O 21.7 Solidago sp? A. O 60.9 Glycine max G O 64.2 Stellaria graminea linné A. O 40.2 Glycyrrhiza glabra G R 53.4 Tamarindus indica A. O 59.2 Hamamelis virginiana G R 88.4 Taraxacum officinale A. O 88.6 Heliotropium arborescens G O 23.O Thalictrum aquilegiifolium A. O 65.2 Huniulus lupulus G R 1OO.O Thalictrum Aquilegiifolium A. O 44.5 Huniulus lupulus G O 90.2 Thuja Occidentalis A. O 50.6 Hydrastis canadensis G O 30.9 Thymus praecox subsp arctitus A. O 23.9 Hylotelephium G R 43.8 Tiarella A. R 34.4 Hypericum henryi G R 50.3 Vaccinium augustifolium A. R 67.2 Iberis Sempervirens G O 87.7 Vaccinium macrocarpon A. R 37.1 Lathyrus Sativus G R 25.9 Vitia sp. A. R 93.7 Ligularia dentata G O 31.5 Xanthium Strunnarium A. O 83.2 Lunaria annua G O 59.7 Yucca filamentosa A. O 34.5 Lythrum Salicaire G R 33.1 Zea mayS A. O 29.7 Melissa officinalis G O 27.6 Zea mayS A. O 93.2 Miscanthus Saccharifiorus G O 3O.7 Achillea tonnentosa G O 41.O Nicotiana rustica G O 54.8 Adiantum tenerun G R 30.2 Nicotiana tabacunn G O 36.2 Alcea rosea G O 37.7 Nigella Sativa G O 40.3 Alchemilia mollis G R 32.8 Origan G O 98.8 Allium SchoenoporaSun G O 49.3 Origanum majorana G O 48.9 Allium tuberoSun G O 79.1 Panax quinquefolius L. G O 21.1 Allium tuberoSun G O 77.4. Panicum miliaceum G R 1OO.O Allium victorialis G O 45.5 Passiflora caerula G O 66.2 Althaea officinalis G O 67.2 Petroselinum crispum G O 65.O anaranthus gangeticus G O 23.5 Phaseolus vulgaris G R 40.3 Anaphais margaritacea G R 34.7 PhySOStegia virginiana G O 74.O Angelica dahurica G R 27.9 Phytolacca americana G O 1OO.O Anthenis nobilis G O 42.3 Plantago major G O 60.9 Apium graveolens G O 25.7 Plectranthus fruticosus G O 29.2 Apium graveolens G O 27.4 Polygonum aviculare linné G R 45.6 ArctostaphyloS uva-ursi G R 94.5 Pongania pinnata G O 41.7 Aronia melanocarpa G R 74.5 Pulmonaria officinalis G O 36.9 Aronia melanocarpa G O 21.3 Pulmonaria Saccharata G O 24.7 Aronia melanocarpa (Michx.) Ell. G R 79.9 Raphanus Sativus G O 38.9 Aronia melanocarpa (Michx.) Ell. G R 28.3 Raphanus Sativus G O 86.4 Asarun europaeum G O 55.4 Beta vulgaris G R 40.O Atropa belladonna G O 58.9 Beta vulgaris spp. Maritima G O 31.4 Begonia emini G O 24.7 Betula glandulosa G R 38.5 Begonia glabra G O 42.9 Calendula officinalis G O 36.2 Begonia mani G O 32.1 Capsicum annus G O 49.9 Begonia polygonoides G O 38.2 Chrysanthemum balsamita G O 1OO.O Berberis vulgaris G O 42.3 Chrysanthemun balsamina G O 33.1 Beta vulgaris G R 75.3 Cynara Scolynus G O 51.9 Beta vulgaris G O 28.7 Daucus Carota G O 813 Beta vulgaris G O 21.7 Silene vulgaris G O 35.5 Rumex crispus linné A. R 65.2 Solarium dulcanara G O 56.9 Salvia elegens A. O 32.6 Solidago Canadensis G O 99.8 Saivia nenorosa A. O 26.2 Solidago Canadensis G O 1OO.O Salvia Officianalis A. O 26.3 Solidago sp? G O 71.8 Saivia Sciarea A. R 51.6 Sorghum caffronun G O 34.5 Daucus carota G O 27.2 Tamarindus indica G O 65.4 Dirca palustris G R 1OO.O Taraxacum officinale G O 82.7 Echinacea purpurea G O 22.9 taraxacum Oficinale G O 42.7 Equisetum hyenale G O 1OO.O Tetradenia riparia G O 32.5 Erigeron Canadensis G O 73.3 Thalictrum aquilegiifolium G O 62.1 Erigeron Speciosus G O 22.9 Thuja Occidentalis G O 57.7 (lindl.) D.C. Thymus vulgaris "Argenteus” G O 40.7 Eruca weSicaria G O 29.2 Tiarella G R 39.0 Erysimum perofskianum Fish. S. G O 89.8 Tropaeoium nails G O 36.6 Fenouil bronze G R 23.7 TuSSilago farfara G O 26.8 US 2004/0175439 A1 Sep. 9, 2004 44

TABLE 5-continued TABLE 5-continued

Cath B Cath B Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Vaccinium angustifolium G R 26.4 chrysanthemun coronarium T O 59.2 Vaccinium angustifolium G R 89.1 (Chip Suey) Vaccinium macrocarpon G R 33.9 Citrus paradisi T R 1OO.O Vitia sp. G R 1OO.O Citrus Sinensis T R 1OO.O Vitia sp. G R 90.9 Cocos nucifera T R 1OO.O Vitis sp. G O 37.1 Cocos nucifera T O 71.9 Achillea millefolium T O 44.1 Convailaria maialis T O 67.1 Aconitun napeius T O 27.4 Conchorus oitorius T R 26.0 Aescuius hippoca Stanium T R 84.2 Crataegus Sanguinea T O 33.1 Aescuius hippoca Stanium T O 47.3 Cryptotaenia Canadensis T R 23.1 Alcea rosea "Nigra” T O 24.3 Cucumis anguria T O 26.4 Alchemilia mollis T R 24.9 Cucumis sativus (Fanfare) T O 25.7 Allium ascaionicum T O 31.1 Cydonia oblonga T R 23.6 Allium cepa gr. Cepa T O 39.4 Datura Stranonium T O 61.4 Allium cepa gr. Cepa T R 23.2 Daucus Carota T R 21.1 Allium cepa gr. Cepa T O 45.5 DioSpiros Kaki T R 1OO.O Allium fistulosum T O 21.9 Echinacea purpurea T O 27.8 Allium grande T O 39.5 Eriobotrya japonica T R 25.2 Allium tuberoSun T O 26.6 Eruca weSicaria T O 34.5 Allium tuberoSun T O 33.1 Erysimum perofskianum Fish. S. T O 91.O Allium tuberoSun T O 72.3 Fragaria x ananassa T R 37.5 Allium tuberoSun T R 22.6 Fucus vesiculosis T R 87. Allium victorialis T O 42.3 Fumaria officinalis T O 44.4 Alpinia Oficinarum T O 57.4 Gaultheria procumbens T R 748 Alpinia Oficinarum T R 88.9 Gentiana macrophylla T O 44.5 Aithacea officinalis T O 51.5 Glyceria maxima T O 37.6 Althaea officianalis T O 25.2 Anthriscus cerefolium T O 21.7 Anelanchier Canadensis T O 20.8 Aralia cordata T R 44. Anelanchier Canadensis T R 42.1 Aronia melanocarpa T R 33. Ansonia tabernaemontana T O 30.2 Aronia melanocarpa T R 1OO.O Ananas COmoSuS T R 36.2 Aronia melanocarpa (Michx.) Ell. T R 35.O Anaphais margaritacea T R 33.9 Aronia prunifolia T R SO.4 Angelica dahurica T R 40.7 Artemisia draculus T O 42.5 Angelica Sinensis syn. T O 91.O Asarun europaeum T O 39.4 A. polymorpha Asclepias incarnate L. T O 48.7 Anthriscus cerefolium T R 23.3 Asclepias tuberosa T O 21.5 Rhus aromatica G O 49.1 ASctinidia chinensis T O 24.9 Ribes nigrum L. G O 20.6 Atriplex hortensis T O 22.4 Rubus ideaus G R 56.9 Atropa belladonna T O 94. Rubus Occidentalis G R 61.3 Iberis Sempervirens T O 90.8 Saponaria Oficinalis G O 48.3 Jeffersonia diphylla T O 43.0 Sarriette vivace G O 44.6 Jugians nigra T R 66.7 Satureia repandra G O 72.3 Kochia Scoparia (L) Schrad. T O 38.4 Sesamun indicum G O 46.8 Kranneria Triandra T R 63.6 Sidalcea G O 55.2 Lentinus edodes T R 1OO.O Aubepine, hawthorne T R 72.7 Lentinus edodes T R 26.2 Begonia convolvulacea T O 32.1 Ligularia dentate T O 34.9 Begonia emini T O 40.4 Ligustrum vulgare T O 29.5 Begonia glabra T O 84.3 Lunaria annua T O 72.3 Begonia mani T O 64.2 Lunaria annua T R 51.1 Berberus vulgaris T O 35.4 Lupinus polyphyllus lindl. T O 47.4 Beta vulgaris T O 34.1 Lychnis chalcedonica T O 34.4 Beta vulgaris T R 86.7 Lythrum Salicaire T R 53.8 Beta vulgaris T O 23.8 Mangifera indica T R 1OO.O Beta vulgaris T R 79.4 Mangifera indica T O 29.3 Beta vulgaris T O 34.2 Nigella Sativa T O 26.1 Beta vulgaris T R 20.8 N T O 73.6 Beta vulgaris T R 37.O N T R 25.4 Beta vulgaris spp. Maritima T R 83.6 N T R 24.6 Betula glandulosa T R 62.5 N T R 49.8 Borago officinalis T O 23.5 N T O 43.6 Brassica Napus T O 27.6 N T R 28.4 Brassica oleracea T O 21.8 Optunia sp. T R 1OO.O Brassica oleracea T O 22.3 Panax quinquefolius L. T O 27.4 Butomus unbellatus T O 20.8 Passiflora caerula T O 39.8 Canna edulis T R 1OO.O Pastinaca Satiya T O 20.5 cannelle T R 99.5 Perroselinum crispum T O 60.9 Carica papaya T R 1OO.O Phaseolus vulgaris T O 37.5 Chrysanthemum balsamita T O 89.3 PhySOStegia virginiana T O 64.2 Chrysanthemum parthenium T R 44.6 Phytolacca americana T O 51.9 chrysanthemun coronarium T O 28.7 Phytolacca americana T O 1OO.O (Chip Suey) Plectranthus fruticosus T O 23.4 US 2004/0175439 A1 Sep. 9, 2004 45

TABLE 5-continued TABLE 5-continued

Cath B Cath B Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Polygonatium Odoratun T O 1OO.O Sesamun indicum T O 78.6 Polygonium chinense T R 33.6 Sidaicea T O 42.9 Pontederia cordata T O 26.2 Portulacea oleracea T O 20.7 Primula veris T O 58.2 Prunus persica T R 1OO.O O150 Prunus persica T R 1OO.O (hybride de la peche) TABLE 6 Pulmonaria Officinalis T O 22.8 Punica granatun T R 1OO.O Cath D Pyrus pyrifolia T R 22.4 Radix Paeonia rubra T O 39.8 Nom latin Stress Extrait Inhibition (%) Rahminus franguia T R 25.3 Raphanus Sativus T O 45.8 Agastache foeniculum A. O 91.6 Rhus trilobata T O 2O2 Agropyron cristatun A. O 24.5 Glycine max Envy T O 40.3 Agropyron repenS A. O 75.2 Glycyrrhiza glabra T R 37.7 Agrostis Stofonifera A. O 94.7 Hamamelis virginiana T R 78.3 Alchemilia mollis A. O 39.0 Helichrysum angustifolium T R 21.8 Allium Sativum A. R 1OO.O Heliotropium arborescens T O 26.8 Allium Schoenopra Sun A. R 40.O Huniulus lupulus T R 84.7 Althaea officinalis A. O 96.5 Huniulus lupulus T O 39.2 Anaranthus gangeticus A. R 67.4 Huniulus lupulus T O 1OO.O Anaranthus gangeticus A. O 74.3 Huniulus lupulus T R 1OO.O Amaranthus retroflexus A. O 1OO.O Hydrastis canadensis T I 42.7 Ambrosia artemisiifolia A. O 75.4 Hypericum henryi T R 51.8 Anethum graveolens A. O 48.7 Hypericum perforatum T O 52.3 Angelica archangelica A. O 27.6 Hypomyces lactiflorum T O 30.1 Anthenis nobilis A. O 56.2 Silene vulgaris T O 51.3 Anthenis tinctoria A. S 42.3 Solidago hybrida T O 92.8 Aralia cordata A. R 1OO.O Solidago Hybrida T O 1OO.O Aralia nudicaulis A. R 44.8 Solidago Hybrida T R 1OO.O Arctium minius A. O 93.2 Solidago sp? T O 39.6 Arctium minius A. O 1OO.O Tamarindus indica T O 64.2 Aronia melanocarpa A. O 22.8 Tanacetum balsania T O 1OO.O Artemisia abrotanium A. O 31.3 Tanacetum vulgare T O 23.3 Artemisia abrotanium A. O 43.6 Taraxacum officinale T O 90.9 Artemisia absinthium A. O 58.3 Taraxacum officinale (Red ribe) T O 34.5 Artemisia Absinthium A. O 71.4 Thuja Occidentalis T O 37.6 Artemisia dracunculus A. O 70.5 Thymus serpyllum T O 20.6 Artemisis Ludoviciana A. O 74.4 Tiarella T R 35.6 Artemisis Ludoviciana A. O 1OO.O Tragopogon sp. T R 21.1 Asparagus Officinalis A. O 61.9 Trigonelia foenum graecum T R 97.3 Aster sp A. O 1OO.O Tropaedium nails T O 58.8 Aster sp A. O 1OO.O Tropaedium nails T R 28.6 Atropa belladonna A. O 1OO.O Tropaedium nails T O 36.7 Beckmannia eruciformis A. R 22.1 Tsuga diversifolia T R 64.O Beckmannia eruciformis A. O 48.3 Vaccinium angustifolium T R 72.2 Beta vulgaris A. R 21.2 Vaccinium angustifolium T R 50.7 Beta vulgaris A. R 1OO.O Vaccinium macrocarpon T R 52.6 Beta vulgaris spp. Maritima A. O 30.8 Vitia sp. T O 35.1 Betta vulgaris A. O 1OO.O Vita sp. T R 98.9 Brassica napus A. R 63.6 Vitis sp. T R 32.6 Brassica oleracea A. R 33.3 Weigela coracensis T R 24.6 Brassica rapa A. R 23.8 Zea mayS T R 1OO.O Brassica rapa A. O 26.1 Zea mayS T R 48.1 Bronius inermis A. O 59.6 Ribes uva-crispa T R 34.2 Calamintha nepeta A. R 24.0 Rosa Rugosa "Alba” T O 45.4 Campanula rapunculus A. O 41.6 Rubus idaeus T R 31.2 Canna edulis A. O 1OO.O Rubus idaeus L. T O 42.7 Capsella bursa-pastoris A. O 36.7 Rubus ideaus T R 74.2 Capsicum annuum A. R 25.8 Rubus Occidentalis T R 68.1 Capsicum annuum A. R 28.2 ... 1 Capsicum annuum A. O 64.7 Rumex crispus linne T R 37.9 Capsicum annuum A. R 76.9 Saivia nenorosa T O 38.2 Capsicum fruitesCens A. O 44.1 Sambucus canadensis T O 27.5 Carthamus tinctorius A. O 42.9 Sambucus ngra T O 30.8 Carium carvi A. R 28.6 Sanguisorba minor T R 78.3 Chaerophyllum bulbosom A. O 1OO.O Saponaria Oficinalis T O 68.7 Chelidonium maius A. R 1OO.O Saponaria Oficinalis L. T O 44.2 Chenopodium bonus-henricus A. O 543 Satureia hortensis T O 62.1 Chenopodium quinoa A. R 22.2 Sechium edule T O 34.4 Chrysanthemum coronarium A. O 96.8 US 2004/0175439 A1 Sep. 9, 2004 46

TABLE 6-continued TABLE 6-continued

Cath D Cath D Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Citrulius ianatus A. R 35.9 Panax quinquefo?ius A. O 35.1 Citrulius ianatus A. O 76.5 Panax quinquefo?ius A. O 40.4 Coix Lacryma-Jobi A. O 2O.9 Pastinaca Satiya A. O 74.4 Coix Lacryma-Jobi A. O 93.2 Perilla frutescens A. O 86.7 Conus Canadensis A. O 30.9 Perilla frutescens A. R 1OO.O Cuburbita pepo A. O 21.9 Petasites japonicus A. O 43.5 Cucunnis meio A. O 44.1 Petroselinum crispum A. O 1OO.O Cucunnis Sativus A. O 21.3 Phaiaris arundinacea A. O 21.3 Cucunnis Sativus A. R 33.3 Phaiaris canariensis A. O 22.0 Cucurbita Maxina A. R 1OO.O Phaseolus coccineus A. O 68.8 Cucurbita noSchata A. R 20.5 Phaseolus nungo A. S 58.5 Cucurbita pepo A. O 31.9 Phaseolus nungo A. O 1OO.O Cucurbita pepo A. R 40.9 Phaseolus vulgaris A. O 33.3 Cucurbita pepo A. O 41.2 Phaseolus vulgaris A. O 8O.3 Curcuna zedoaria A. O 26.3 Phleum pratense A. O 2O2 Cymbopogon martini A. O 77.8 Physalisixocarpa A. R 1OO.O Daucus carota A. O 55.1 Pimpinella anisum A. O 86.7 Daucus carota A. R 1OO.O Plantago major A. O 99.0 Dipsacus Sativus A. O 21.1 Plectranthus sp. A. R SO.O Elymus iunceus A. O 27.7 Plectranthus sp. A. O 64.O Eschscholzia californica A. O 44.4 Polygonum aviculare A. O 55.7 Foeniculum vulgare A. O 81.8 Poterium Sanguisorba A. R 1OO.O Forsythia Intermedia A. O 40.4 Poterium Sanquisorba A. O 23.4 Forsythia intermedia A. R 1OO.O Prunus Tomentosa A. O 27.6 Fragaria x ananassa A. R 38.5 Raphanus Sativus A. O 36.8 GainSoga ciliata A. O 46.7 Raphanus Sativus A. R 1OO.O Galium odoratum A. O 21.6 Rheun rhabarbarium A. R 33.O Galium odoratum A. R 22.7 Ribes nigrum A. R 21.1 Gaultheria hispidula A. R 71.9 Ribes nigrum A. O 32.6 Gaultheria hispidula A. O 90.2 Ribes rubrun A. O 24.5 Gentiana lutea A. R 1OO.O Ribes Sylvestre A. O 21.1 Giechona hederacea A. O 32.7 Ribes Sylvestre A. R 30.3 Glycine max A. S 55.1 Rosa rugosa A. R 21.1 Glycine max A. R 1OO.O Rosa rugosa A. O 36.6 Glycyrrhiza glabra A. R 1OO.O Rosa rugosa A. O 40.2 Guizotia abyssinica A. O 73.8 RoSmarinus officinalis A. O 95.7 Hedeoma pullegioides A. O 1OO.O Rubus canadensis A. R 25.8 Helianthus tuberosus A. O 37.2 Rubus canadensis A. O 31.7 Hordeum hexaStichon A. R 34.6 Rubus idaeus A. O 85.9 Hordeum hexaStichon A. O 63.6 Rubus ideaus A. R 66.7 Hordeum vulgare A. O 66.7 Runnex acetoSella A. O 27.4 Hordeum vulgure subsp. Vulgare A. O 33.3 Rumex crispus A. O 25.0 Hypericum henryi A. O 66.7 Runnex Sciutatus A. O 21.3 HySSopus officinalis A. O 1OO.O Salvia Officinalis A. O 21.3 Ipomoea Batatas A. O 55.1 Salvia Officinalis A. O 85.1 Iris versicolor A. R 24.1 Salvia Officinalis A. R 1OO.O Iris versicolor A. O 30.8 Saivia Sciarea A. O 29.9 Lathyrus Sativus A. O 20.6 Sanguisorba Officinalis A. O 23.1 Laurus nobilis A. O 33.3 Mentha piperita A. R 1OO.O Levisticum officinale A. O 87.6 Mentha Suaveolens A. O 53.2 Linum usitatis.Simum A. R 21.4 Nepeta cataria A. O 1OO.O Linum usitatis.Simum A. O 44.4 Nicotiana tabacunn A. O 37.7 Lolium perenne A. O 30.9 Soianum melanoceraSun A. S 44.6 Lotus corniculatus A. O 23.4 Soianum melanoceraSun A. R 6O.O Lycopersicon eSculentum A. R 40.O Soianum tuberosum A. O 29.2 Matricaria reciutita A. S 56.4 Solidago sp A. O 98.4 Medicago Sativa A. R 20.5 Spinacia Oileracea A. O 40.5 Melissa officinalis A. O 1OO.O Spinacia Oileracea A. S 57.7 Mentha piperita A. O 22.7 Stachys affinis A. O 23.8 Cichorium endivia susp. A. R 36.O Stachys byzantina A. O 96.1 Endivia Stellaria graminea A. O 34.4 Cichorium endivia susp. A. O 78.4 Stellaria media A. O 24.6 Endivia Symphytum officinale A. O 87.7 Cichorium intybus A. O 1OO.O Symphytum officinale A. O 1OO.O Citrulius ianatus A. O 22.7 Tanacetum cinerariifolium A. O 70.7 Citrulius ianatus A. R 26.7 Tanacetum parthenium A. R 40.O Nicotiana tabacunn A. R 44.3 Tanacetum parthenium A. O 74.7 Oenothera biennis A. O 23.8 Tanacetum parthenium A. R 1OO.O Oenothera biennis A. O 40.O Tanacetum vulgare A. O 26.7 Oenothera biennis A. R 1OO.O Tanacetum vulgare A. R 32.7 Origanum vulgare A. O 94.7 Tanacetum vulgare A. O 98.4 Panax quinquefolius A. O 29.8 Tanacetum vulgare A. O 1OO.O US 2004/0175439 A1 Sep. 9, 2004 47

TABLE 6-continued TABLE 6-continued

Cath D Cath D Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Taraxacum officinale A. R 22.7 CapSella bursa-pastoris G O 3O.O Taraxacum officinale A. O 1OO.O Capsicum annuum G O 27.9 Teucrium chamaedrys A. O 1OO.O Capsicum annuum G R 33.3 Thymus praecox subsp A. O 75.6 Capsicum annuum G R 35.9 arcticus Capsicum annuum G R 41.O Thymus praecox subsp A. O 1OO.O Capsicum annuum G S 43.1 arcticus Capsicum annuum G O 56.9 Thymus serpyllum A. O 78.1 Capsicum fruitesCens G O 60.8 Thymus vulgaris A. O 90.9 Carthamus tinctorius G O 30.2 Trichosanthes kirillowii A. O 1OO.O Carium carvi G O 28.6 Trifolium incarnatum A. S 76.9 Chaerophyllum bulbosum G O 88.9 Trifolium pannonicum A. O 72.6 Chrysanthemum coronarium G O 82.5 Trifolium pratense A. O 1OO.O Cicer arietinium G R 31.8 Trifolium repens A. O 1OO.O Cichorium endivia subspendivia G O 1OO.O Triticum durum A. R 22.7 Cichorium intybus G O 1OO.O Triticum spelta A. R 24.O Circium arvense G S 53.8 Triticum spelta A. O 32.4 Circium arvense G O 6.3.3 Typha latifolia A. O 52.1 Citrulius ianatus G O 40.9 Vaccinium Corymbosum A. R 53.3 Citrulius ianatus G O 56.9 Vaccinium macrocarpon A. R 44.3 Coix Lacryma-Jobi G O 1OO.O Valeriana officinalis A. O 23.1 Conus Canadensis G O 2O2 Verbascum thapsus A. O 65.6 Cornus Canadensis G O 35.1 Vitis sp. A. O 33.7 Cucumis anguria G R 40.O Vitis sp. A. R 33.3 Cucurbita maxina G O 31.4 Zea mayS A. R 25.0 Ambrosia artemisiifolia G O 73.8 Zea mayS A. R SO.O Amelanchier alnifolius G O 50.5 Achillea millefolium G O 47.7 Anethum graveolens G O 1OO.O Agropyron repenS G O 93.3 Anthenis nobilis G O 94.3 Alchemilia mollis G O 32.1 Apium graveolens G O 21.9 Allium ascaionicum G O 29.7 Arctium minius G O 65.9 Allium Sativum G R 1OO.O Arctium minius G O 71.7 Allium SchoenopraSun G R 1OO.O ArctostaphyloS uva-ursi G O 84.8 Allium tuberoSun G R 1OO.O Aronia melanocarpa G O 31.5 Althaea officinalis G O 95.6 Foeniculum vulgare G O 1OO.O Anaranthus caudathus G O 95.3 Forsythia intermedia G R 1OO.O Anaranthus gangeticus G O 45.7 Forsythia x intermedia G O 42.1 Amaranthus retroflexus G O 78.3 Galium odoratum G R 63.6 Sanguisorba Officinalis A. R 48.3 Galium odoratum G O 64.7 Santolina Chamaecyparissus A. O 52.9 Gaultheria hispidula G R 63.4 Satureia montana A. O 87.4 Gaultheria hispidula G O 69.6 Scorzonera hispanica A. O 30.8 Giechona hederacea G O 50.5 Secale cereale A. R 21.2 Giechona hederacea G R 1OO.O Senecio vulgaris A. O 42.6 Glycine max G O 27.9 Sesamun indicum A. O 27.3 Glycine max G R 1OO.O Silybum marianum A. O 25.2 Guizotia abyssinica G R 33.3 Sium Sisarun A. O 34.4 Guizotia abyssinica G O 83.6 Soianum dulcanara A. R 21.4 Helianthus annuus G R 1OO.O Arrhenatherun elatius G S SO.8 Helianthus Strunosus G R 28.9 Artemisia abrotanium G O 52.1 Helianthus Strunosus G O 52.2 Artemisia absinthium G O 59.7 Helianthus tuberosus G O 29.3 Artemisia absinthium G O 72.9 Helianthus tuberosus G O 54.9 Artemisia Ludoviciana G O 64.1 Helichrysum thianschanicum G O 30.5 Artemisia Ludoviciana G O 90.7 Heliotropium arborescens G R 29.1 Artemisia vulgaris G O 55.2 Hysopus officinalis G O 1OO.O Artemisia vulgaris G O 83.3 Ipomoea batatas G O 45.8 Asclepias incanata G O 38.9 Lactuca Sativa G O 26.6 Asclepias incanata G O 75.6 Lathyrus Sativus G O 72.7 Asparagus Officinalis G R 27.8 Lathyrus Sylvestris G O 33.3 Aster sp G O 33.3 Lathyrus Sylvestris G R 56.8 Atropa belladonna G O 96.6 Lavandula angustifolia G R 1OO.O Beta vulgaris G O 92.1 Lavandula angustifolia G O 1OO.O Beta vulgaris G R 1OO.O Lavandula latifolia G O 1OO.O Beta vulgaris spp. Maritima G R 1OO.O Leonurus cardiaca G O 1OO.O Borago officinalis G O 1OO.O Levisticum officinale G O 98.1 Brassica napus G R 40.9 Levisticum officinale G R 1OO.O Brassica oleracea G R 66.7 Linum usitatis.Simum G O 42.9 Bronius inermis G O 38.3 Lolium perenne G O 25.5 Calamintha nepeta G R 25.3 Lotus tetragonolobus G R 49.2 Campanula rapunculus G S SO.8 Lupinus polyphyllius G O 33.3 Campanula rapunculus G O 68.8 Lycopersicon eSculentum G O 29.5 Campanula rapunculus G O 69.9 Lycopersicon eSculentum G R 43.3 Canna edulis G S SO.8 Lycopersicon pimpinellifolium G R 1OO.O US 2004/0175439 A1 Sep. 9, 2004 48

TABLE 6-continued TABLE 6-continued

Cath D Cath D Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Maiva noSchata G O 1OO.O Oxalis Deppei G S 44.6 Medicago Sativa G O 32.6 Oxyria digyna G O 21.3 Melissa officinalis G O 1OO.O Panax quinquefolius G O 25.5 Mentha piperita G O 40.3 Panax quinquefolius G O 38.3 Mentha Suaveolens G O 79.2 Panicum miliaceum G R 83.3 Monarda didyma G R 1OO.O Pennisetum alopecuroides G R 21.5 Nepeta cataria G O 1OO.O Petasites japonicus G O 40.6 Ocinum basilicum G O 80.5 Petroselinum crispum G O 1OO.O Oenothera biennis G O 41.7 Peucedanum cervaria G O 42.9 Oenothera biennis G R 1OO.O Phaseolus nungo G O 1OO.O Origanum majorana G O 67.4 Phaseolus vulgaris G O 54.8 Cucurbita maxina G R 40.9 Phaseolus vulgaris G O 67.2 Cucurbita noSchata G O 23.O Thymus praecox subsp arcticus G O 1OO.O Cucurbita noSchata G R 31.8 Thymus Serpyllum G O 1OO.O Cucurbita noSchata G S 47.7 Thymus vulgaris G O 64.4 Cucurbita pepo G O 29.8 Thymus x citriodorus G O 72.7 Cucurbita pepo G R 53.3 Tiarella cordifolia G O 92.4 Cymbopogon martini G O OO.O Trifolium hybridum G O 29.5 Cynara Scolynus G O 27.3 Trifolium pannonicum G O 54.7 Datura metel G O 54.1 Trifolium pratense G O 92.9 Daucus carota G O 28.6 Trifolium repens G O 1OO.O Daucus carota G R OO.O Triticum spelta G R 37.3 Digitalis purpurea G R OO.O Triticum turgidium G O 59.5 Dirca palustris G R 24.5 Typha latifolia G O 23.4 Elymus iunceus G O 38.3 Vaccinium corymbosum G O 26.5 Erigeron Speciosus G O 73.7 Vaccinium angustifolium G O 27.7 Plantago major G O 95.2 Vaccinium macrocarpon G R 33.O Plectranthus sp. G R OO.O Valeriana officinalis G R 27.6 Plectranthus sp. G O OO.O Valeriana officinalis G O 51.3 Poa compressa G O 2O2 Verbascum thapsus G O 21.3 Portulaca oleracera G O 6O.O Vinca minor G O 28.6 Potentilla anSerina G R OO.O Vitis sp. G R 40.O Poterium Sanguisorba G O 21.3 Vitis sp. G O 42.6 Poterium Sanguisorba G R OO.O Zea mayS G R 26.9 Prunella vulgaris G O 70.3 Zea mayS G R 1OO.O Raphanus Raphanistrum G O 33.3 Perilla frutescens T O 96.O Raphanus Raphanistrum G R 8O.O Perilla frutescens T R 1OO.O Raphanus Sativus G O 52.6 Abies lasiocarpa T O 25.6 Raphanus Sativus G R 1OO.O Agastache foeniculum T O 1OO.O Ribes nigrum G O 42.1 Agropyron cristatun T O 2O2 Ribes Sylvestre G R 32.O Agrostis aiba T O 24.5 Ricinius communis G R 1OO.O Alchemilia mollis T O 33.3 Rosa rugosa G O 52.4 Alchemilia mollis T S 49.2 Rosa rugosa G O 90.2 Alchemilia mollis T O 66.2 RoSmarinus officinalis G O 1OO.O Allium anpeiopraSun T O 1OO.O Rubus ideaus G O 34.8 Allium ascaionicum T O 29.7 Rubus Occidentalis G R 6O.O Allium ascaionicum T R 38.7 Rubus Occidentalis G O 65.3 Allium cepa T R 1OO.O Rumex crispus G O 43.3 Allium tuberoSun T R 1OO.O Ruta graveolens G O 23.O Alpinia officinarum T R SO.O Salvia Officinalis G O 1OO.O Althaea officinalis T O 58.6 Salvia Officinalis G R 1OO.O Anaranthus candathus T R 22.9 Sambucus Canadensis G O 80.6 Anaranthus candatus T O 93.2 Sambucus ebulus G R 21.1 Anaranthus caudathus T O 1OO.O Sambucus ebulus G O 36.8 Anaranthus gangeticus T O 57.1 Sanguisorba Officinalis G O 43.6 Amaranthus retroflexus T O 1OO.O Santolina Chamaecyparissus G O 50.6 Ambrosia artemisiifolia T O 86.9 Saponaria Oficinalis G O 85.6 Stachys byzantina G O 28.6 Satureia hortensis G R 36.8 Stellaria graminea G O 39.3 Satureia hortensis G O 68.4 Stellaria media G O 21.3 Senecio vulgaris G O 31.1 Symphytum officinale G R 37.8 Sesamun indicum G O 27.3 Symphytum officinale G S 43.1 Sium Sisarun G O 20.8 Symphytum officinale G O 92.6 Sium Sisarun G O 47.8 Symphytum officinale G O 1OO.O Soianum melanoceraSun G O 23.5 Tanacetum cinerariifolium G O 91.3 Soianum melongens G O 28.6 Tanacetum parthenium G R 6O.O Soianum melongens G R 41.2 Tanacetum parthenium G O 86.7 Solidago sp G O 72.1 Tanacetum vulgare G O 44.4 Sonchus oleraceus G O 95.1 Tanacetum vulgare G O 67.9 Stachys Affinis G O 38.1 Tanacetum vulgare G O 85.7 Origanum vulgare G O 1OO.O taraxacum Oficinale G R 40.9 Oxalis Deppei G O 22.2 taraxacum Oficinale G O 1OO.O US 2004/0175439 A1 Sep. 9, 2004 49

TABLE 6-continued TABLE 6-continued

Cath D Cath D Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Teucrium chamaedrys G R 33.3 Forsythia intermedia T O 50.9 Teucrium chamaedrys G O 66.7 Forsythia x intermedia T O 57.9 Thymus fragantissinus G O 24.1 Fucus vesiculosus T O 83.7 Thymus praecox subsp arcticus G R 25.0 Fucus vesiculosus T R 1OO.O Thymus praecox subsp arcticus G O 92.7 GainSoga ciliata T O 56.7 Beta vulgaris T O 25.5 Galium aparine T O 60.5 Beta vulgaris T O 28.6 Galium odoratum T R 31.8 Beta vulgaris T R 34.6 Gaultheria hispidula T O 33.7 Beta vulgaris T S 43.6 Gaultheria procumbens T O 25.0 Beta vulgaris T O 54.5 Gentiana lutea T O 98.1 Beta vulgaris T R 1OO.O Gentiana macrophylla T O 1OO.O Beta vulgaris spp. Maritima T R 1OO.O Giechona hederacea T O 62.6 Brassica nigra T R 45.5 Glycine max T O 26.2 Brassica oleracea T O SO.O Glycyrrhiza glabra T R SO.O Brassica oleracea T R 1OO.O Glycyrrhiza glabra T S 51.3 Bronius inermis T O 30.9 Guizotia abyssinica T O 39.3 Calamagrostis arundiflora T O 85.6 Guizotia abyssinica T R 1OO.O Calendula officinalis T O 23.7 Hedeoma pullegioides T O 1OO.O Campanula rapunculus T O 25.0 Helianthus annus T O 75.8 Canna edulis T O 26.3 Helianthus Strunosus T R 55.6 CapSella bursa-pastoris T O 21.7 Helianthus tuberosus T O 22.1 Capsicum annum T O 46.1 Helichrysum angustifolium T O 96.1 Capsicum annuum T R 20.5 Helichrysum thianschanicum T O 70.5 Capsicum annuum T O 23.3 Heliotropium arborescens T O 83.2 Capsicum annuum T R 41.O Helleborus niger T O 24.1 Capsicum frutescens T O 58.8 Herba Schizonepetae T O 60.5 Carthanus tinctorius T O 36.5 Hibiscus cannabinus T S 52.6 Carium carvi T O 88.6 Hordeum vulgare T O 77.8 Chaerophyllum bulbosum T O 25.0 Hydrastis canadensis T O 64.9 Chaerophyllum bulbosum T O 95.2 Hypericum henryi T O 1OO.O Chelidonium maius T O 27.1 Hypericum perforatum T R 31.0 Chelidonium maius T R SO.O HySSopus officinalis T O 1OO.O Chenopodium bonus-henricus T O 6O.O Inula helenium T O 1OO.O Chenopodium quinoa T R 31.5 Citrulius ianatus T O 62.7 Chenopodium quinoa T O SO.O Coix Lacryma-Jobi T O 77.3 Chrysanthemum coronarium T R 65.5 Coriandrum Sativum T O 90.0 Chrysanthemum coronarium T O 1OO.O Conus Canadensis T O 29.3 Cicer arietinium T R 27.3 Cucumis anguria T R SO.O Cichorium endivia subspendivia T R 27.3 Cucumis anguria T O 70.1 Cichorium endivia subspendivia T O 97.3 Cucunnis melo T R 20.5 Cichorium intybus T O 1OO.O Cucunnis melo T O 51.O Cinicifuga racenOSa T R 22.2 Cucunnis Sativu.S. T O 23.4 Circium arvense T O 78.3 Cucurbita maxina T O SO.O Citrulius ianatus T R 26.7 Cucurbita noSchata T O 84.9 Citrulius ianatus T O 45.5 Cucurbita pepo T R 20.5 Amelanchier alnifolia T O 50.5 Cucurbita pepo T O 39.2 Anthenis nobilis T O 1OO.O Cucurbita pepo T S 53.8 Anthriscus cerefolium T O 1OO.O Curcuna zedoaria T O 24.6 Aralia cordata T R 1OO.O Cymbopogon citratus T O 1OO.O Arctium minus T O 68.3 Cynara Scolynus T R 33.3 Aronia melanocarpa T O SO.O Dactilis Gionerata T O 2O2 Aronia prunifolia T O 44.7 Datura metel T O 37.8 Arrhenatherun elatius T O 78.7 Datura Stranonium T R SO.O Artemisia absinthium T O 58.4 Daucus Carota T R 21.1 Artemisia dracunculus T R 28.6 Daucus Carota T O 30.3 Artemisia dracunculus T O 86.3 Daucus Carota T O 49.3 Artemisia Ludoviciana T O 48.8 Daucus Carota T S 52.3 Artemisia vulgaris T O SO.O Lycopersicon pimpinellifolium T R 1OO.O Artemisia vulgaris T O 82.8 Maius hupehensis T R 1OO.O Asclepias incarnata T O 72.9 Malva Sylvestris T O 1OO.O Asparagus Officinalis T O 69.8 Matricaria spp. T O 1OO.O Aster sp T O 35.O Medicago Sativa T O 27.7 Avena Sativa T O 31.8 Melissa officinalis T O 1OO.O Baptisia tinctoria T O 33.8 Menyanthes trifoliata T O 44.9 DioScorea batatas T S 41.5 Menyanthes trifoliata T R SO.O Dipsacus Sativus T O 73.7 Miscanthus Sinensis T R 23.5 Dirca palustris T O 88.5 Miscanthus Sinensis T O 24.6 Eleusine Coracana T S 49.2 Nepeta cataria T O 78.9 Elymus iunceus T O 35.1 Ocinum Basilicum T R 35.7 Erigeron Speciosus T O 67.8 Ocinum Basilicum T O 1OO.O Fagopyrun eSculentum T O 27.3 Oenothera biennis T R 1OO.O Foeniculum vulgare T R 8O.O Origanum vulgare T O 94.7 US 2004/0175439 A1 Sep. 9, 2004 50

TABLE 6-continued TABLE 6-continued

Cath D Cath D Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Origanum vulgare T R 1OO.O Stachys byzantina T O 41.6 Oxalis Deppei T O 21.1 Stellaria graminea T O 62.3 Oxyria digyna T O 24.6 Stipa capiliata T O 27.1 Panax quinquefolius T O 39.4 Symphytum officinale T R 28.9 Panicum miliaceum T R 20.8 Symphytum officinale T O 87.7 Pastinaca Satiya T O 21.3 Symphytum officinale T O 97.8 Pastinaca Satiya T R 25.0 Tanacetum cinerariifolium T O 82.7 Pastinaca Satiya T R 25.0 Pimpinella anisum T O 1OO.O Pastinaca Satiya T O 79.4 Pisun Stativum T O 37.5 Pastinaca Satiya T O OO.O Plantago major T O 1OO.O Petasites Japonicus T O 29.0 Plectranthus sp. T O 36.0 Petroselinum crispum T R 40.O Plectranthus sp. T R 8O.O Peucedanum oreaselinum T S 55.1 Poa pratensis T O 38.3 Pfafia paniculata T R OO.O Populus X petrowskyana T O 25.5 Phaseolus nungo T O 70.2 Prunella vulgaris T O 23.3 Phaseolus vulgaris T O 71.4 Prunella vulgaris T O 88.1 Phaseolus vulgaris T O OO.O Raphanus raphanistrum T O 73.7 Phaseolus vulgaris T R OO.O Raphanus raphanistrum T R OO.O Physalisixocarpa T O 25.5 Raphanus Sativus T S 60.3 Pimpinella anisum T R OO.O Raphanus Sativus T R OO.O Ipomoea batatas T O 91.5 Reseda luteola T O OO.O Iris versicolor T O 35.9 Rheum officinale T O 36.8 Juniperus Communis T O 83.8 Ribes Sativum T O 20.4 Kranneria Triandra T O 25.6 Ribes Sylvestre T R 44.3 Lactuca Sativa T O OO.O Ricinius communis T R OO.O Lathyrus Sativus T R 27.3 RoSmarinus officinalis T R 6O.O Lathyrus Sativus T O 33.3 RoSmarinus officinalis T O OO.O Lathyrus Sylvestris T O 20.3 Rubus canadensis T R 32.O Lathyrus Sylvestris T R OO.O Rubus canadensis T O 34.7 Laurus nobilis T R 23.8 Rubus idaeus T O 93.5 Laurus nobilis T O 26.O Rubus ideaus T R OO.O Lavandula latifolia T R OO.O Rubus occidentalis T O 38.6 Lavandula latifolia T O OO.O Rubus occidentalis T S 52.3 Lens culinaris subsp culinaris T O 21.3 Rubus occidentalis T R OO.O Leonoras cardiaca T O 57.9 Runnex acetoSella T O 26.3 Lepidium Sativum T O 31.6 Rumex crispus T O 3O.O Levisticum officinale T O 90.5 Vaccinium angustifolium T R OO.O Levisticum officinale T R 1OO.O Vaccinium corymbosum T O 21.4 Linum usitatis.Simum T O 23.8 Vaccinium macrocarpon T R 8O.O Lonicera Syringantha T O 79.5 Valeriana officinalis T O 43.6 Lotus corniculatus T R 46.7 Vicia Satiya T S 43.1 Lupinus polyphyllus lindl. T O 35.6 Vitis sp. T O 26.7 Lycopersicon eSculentum T R 6O.O Vitis sp. T R 93.3 Rumex Sciutatus T O 23.O Zea mayS T R 21.2 Ruta graveolens T O 62.1 Zea mayS T R 1OO.O Saccharum officinarum T O 27.0 Tanacetum parthenium T O 94.7 Salvia Officinalis T O 92.0 Tanacetum vulgare T R 28.9 Salvia Officinalis T O 93.3 Tanacetum vulgare T S 47.7 Sambucus Canadensis T O 42.9 Tanacetum vulgare T O 75.6 Sanguisorba Officinalis T O 68.6 Tanacetum vulgare T O 95.2 Santolina Chamaecyparissus T O 66.7 Tanacetum vulgare T O 1OO.O Saponaria Oficinalis T O 36.6 Taraxacum officinale T O 95.3 Saponaria Oficinalis T O 84.7 Thymus praecox subsp arcticus T R 24.4 Satureia montana T O 80.5 Thymus praecox subsp arcticus T O 6O.O Satureia repandra T O 47.1 Thymus praecox subsp arcticus T O 90.0 Senecio vulgaris T O 44.3 Thymus pseudoianuginosus T O 83.9 SRC, italica T g t Thymus Serpylium T O 1OO.O itybun marianum Tiarella cordifolia T O 93.3 Sium sisariii. T O 24.8 Tragopogon porrifolius T O 34.4 Sium Sisarun T R 25.5 Tragopogon porrifolius T O 58.0 Soianum dulcanara T R 21.4 TrichoSanthes kirillowii T R 25.3 Soianum melongena T R 25.8 Trifolium pannonicum T O 61.1 Soianum melongena T O 34.9 Soianum tuberosum T O 38.1 Trifolium pratense T O 92.9 Solidago Canadensis T O 1OO.O Trifolium repens T O 1OO.O Solidago sp T O 73.8 Triticum deSilviii. T O 29.5 Sonchus oleraceus T O 1OO.O Triticum durum T O 1OO.O Sorghum durra T O 23.8 Triticum turgidium T O 29.7 Spinacia oleracea T R 29.3 Ulmus annericana T O 76.9 Stachys affinis T R 23.6 Ulmus annericana T O 81.0 Stachys affinis T O 23.9 Urtica dioica T R 40.9 Stachys affinis T O SO.O Vaccinium angustifolium T R 26.3 US 2004/0175439 A1 Sep. 9, 2004 51

TABLE 6-continued TABLE 7-continued

Cath D Cath G Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Vaccinium angustifolium 28.3 Filipendula rubra 77.6 Vaccinium angustifolium 47.6 Foeniculum vulgare 23.3 Fragaria x ananassa 32.3 Fragaria x ananassa 1OO.O Fragaria x ananassa 1OO.O 0151) Fragaria Xananassa 1OO.O TABLE 7 Frangoria x ananassa 1OO.O Frangoria x ananassa 1OO.O Cath G Galinsoga ciliata (Rofiresque) 21.2 Blake Nom latin Stress Extrait Inhibition (%) Gaultheria hispidula (L) Muhl. 85.3 Gaultheria hispidula (L) Muhl. 1OO.O Achillea millefolium 40.1 Gaultheria procumbens 56.1 Achillea millefolium 29.5 Glycine Max 36.0 Acorus Caianus 68.6 Glycine max 38.7 Adiantum pedatun 29.7 Glycyrrhiza glabra 46.2 Agastache foeniculum 36.8 Glycyrrhiza glabra 35.5 Agastache foeniculum 22.4 Glycyrrhiza glabra 1OO.O Agropyron rupens 24.5 Hamamelis virginiana 1OO.O Alchemilia mollis 1OO.O Helianthus tuberosus 22.6 Alchemilia mollis 81.1 Helichrysum angustifolium 82.6 Alchemilia mollis 51.5 Heliotropium arborescens 57.3 Alchemilia mollis 78.6 Heliotropium arborescens 57.2 Alchemilia mollis 82.9 Hordeum vulgare 34.3 Alchemilia mollis 35.6 Hypericum henryi 30.4 Alkanna tinctoria 51.6 Hypericum perforatum 1OO.O Alkanna tinctoria 1OO.O Inula helenium 64.O Allium TuberoSun 20.6 Satistinctoria 94.O Althaea officinalis 21.6 Laurus nobilis 49.9 Althaea officinalis 39.6 Lavendula latifolia 1OO.O Ambrosia artemisiifolia linné 47.6 Lavendula latifolia 48.7 Ambrosia artemisiifolia linné 38.2 Leonorus cardiaca 1OO.O Amelanchier Sanguinea (Pursh) DC. 29.7 Levisecum officinale 46.8 Angelica archangelica 68.1 Lolium multiflorum 34.1 Anthenis tinctoria 26.O Melissa officinalis 54.1 Anthenis tinctoria 28.4 Melissa officinalis 1OO.O Anthenis tinctorium 46.9 Melissa officinalis 80.7 Arachis hypogaea 84.5 Melissa officinalis 1OO.O Aralia nudicaulis 61.9 Mentha pullegium 29.1 ArctostaphyloS uva-ursi 25.0 Mentha Spicata 47.O ArctostaphyloS uva-ursi 1OO.O Nepeta cataria 57.6 ArctostaphyloS uva-ursi 38.4 Ocrothera biennis 33.1 Aronia melanocarpa (Michx.) Ell. 24.4 Oenothera biennis linné 47.4 Aronia melanocarpa (Michx.) Ell. 27.3 Oenothera biennis linné 1OO.O Aronia melanocarpa (Michx.) Ell. 47.8 Origanum majorana 34.6 Artemisia dracunculus Sati va 32.2 Origanum vulgare 65.9 Artemisis Ludoviciana 88.8 Origanum vulgare 48.2 Aster sp? 47.2 Origanum vulgare 7O.O Aster sp? 1OO.O Origanum vulgare 62.9 Beta vulgaris 23.9 Origanum vulgare 68.4 Brassica napus 22.3 Origanum vulgare 81.9 Brassica napus 22.8 Origanum vulgare 61.3 Brassica nigra 47.2 Origanum vulgare 21.7 Brassica rapa 46.0 Oxyria digyna 40.1 Capsella bursa-pastoris (linné) medicus 43.4 Perilla frutescens 65.O Chaerophyllum bulbosom 90.7 Perilla frutescens 51.9 Chaerophyllum bulbosom 57.4 Peucedanum cervaria 28.3 Chenopodium bonus-heniricus 23.7 Dirca palustris 24.9 Chichorium endivia 53.0 Dirca palustris 47.O Chrysanthemum leucanthemum linné 55.5 Dryopteris filix-mas 24.1 Cicer arietinium 26.2 Dryopteris filix-mas 95.7 Cichorium intybus 1OO.O 80.7 83.6 Echinacea purpurea Cichorium intybus 27.8 Cichorium intybus 51.O Phytolacca americana Crataegus sp? 1OO.O Plantago Coronopus 22.7 Crataegus sp? 81.6 Polygonum aviculare linné 76.O Cymbopogan citratus 33.9 Poterium Sanguisorba 20.1 Datisca cannabina 2O2 Poterium Sanguisorba 93.1 Daucus carota 62.O Poterium Sanguisorba 47.7 Daucus carota 99.4 Poterium Sanguisorba 36.1 Echinacea purpurea 1OO.O Pteridium aquilinum 25.7 Filipendula rubra 2O2 Pteridium aquilinum 1OO.O US 2004/0175439 A1 Sep. 9, 2004 52

TABLE 7-continued TABLE 7-continued

Cath G Cath G Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Ribes nidigrolaria 51.8 Vitia sp. 28.5 Ribes Nigrum 1OO.O Zea Mays 32.3 Ribes nigrum 33.6 Zea Mays 34.5 Ribes nigrum L. 58.8 Achillea millefolium 30.6 Ribes nigrum L. 21.5 Achillea millefolium 71.1 Ribes Saiivum 21.4 Aconitum napeius 1OO.O Ricinius communis 1OO.O Acorus Caianus 27.8 Rosa rugOSa thunb. 20.1 Adiantum pedatun 1OO.O Rosa rugOSa thunb. 1OO.O Agastache toeniculum "Snow Pike' 46.9 Rosa rugOSa thunb. 1OO.O Agastache toeniculum "Snow Pike' 71.5 RoSmarinus officinalis 1OO.O Alchemilia mollis 1OO.O RoSmarinus officinalis 64.O Alchemilia mollis 52.6 RoSmarinus officinalis 55.6 Alchemilia mollis 80.7 RoSmarinus officinalis 76.7 Alchemilia mollis 33.4 Rubus allegheniensis 32.1 Alchemilia mollis 38.7 Rubus Canadensis 94.5 althaea officinalis 27.5 Rubus Canadensis 64.2 althaea officinalis 36.9 Rubus idaeus 86.O Ambrosia artemisiifolia linné 48.4 Rubus idaeus 29.5 Ambrosia artemisiifolia linné 36.0 Rubus idaeus 38.7 Amelanchier Sanguinea (Pursh) DC. 46.5 Rubus idaeus 41.O Angelica archangelica 39.1 Rubus idaeus 1OO.O Arachis hypogaea 81.8 Rubus idaeus L. 30.2 Aralia nudicaulis 44.9 Rubus idaeus L. 29.4 Arctium minus (Hill) Bernhardi 35.6 Rubus idaeus L. 1OO.O ArctostaphyloS uva-ursi 59.9 Rubus ideaus 1OO.O Aronia melanocarpa (Michx.) Ell. 28.4 Rubus ideaus 67.1 Artemisia Ludoviciana 66.O Rubus Occidentalis 1OO.O Aster sp? 51.8 Rumex crispus linné 1OO.O Aster sp? 1OO.O Salvia elegens 69.7 Beta vulgaris 26.5 Salvia Officinalis 1OO.O Sorghum dochna bicolor 25.6 Salvia Officinalis 58.0 Sorghum durra (Stapif) 46.9 Salvia Officinalis 1OO.O Symphytum officinale 99.4 Salvia Officinalis 39.9 Symphytum officinale 97.8 Salvia Officinalis 45.7 Tanacetum cinerariifolium 28.2 Salvia Officinalis 65.4 Tanacetum parthenium 34.8 Saivia Sciarea 29.1 Tanacetum vulgare 8O.O Santolina 65.5 Tanacetum vulgare 53.8 Satureia montana 72.2 Tanacetum vulgare 35.9 Satureia montana 1OO.O Tanacetum vulgare 68.8 Satureia montana 90.5 Chaerophyllum bulbosum 26.5 Satureia montana 28.9 Chichorium endivia 25.2 Scuttellaria lateriflora 23.7 Chrysanthemum leucanthemum linné 44.2 Sonchus oleraceus L. 25.9 Cicer arietinium 26.1 Peucedanum cervaria 45.1 Cichorium endivia 23.7 Phaseolus Vulgaris 38.4 Cichorium intybus 1OO.O Phaseolus Vulgaris 26.3 Cichorium intybus 79.2 Tanacetum vulgare “Goldsticks' 51.9 Cichorium intybus 82.5 Taraxacum officinale 28.5 Crataegus sp? 27.9 Taraxacum officinale 82.3 Cynara Scolynus 66.3 Thymus praecox subsp arctitus 43.4 Dirca palustris 28.8 Thymus pseudoianuginosus 29.7 Dirca palustris 85.2 Thymus serpyllum 1OO.O Dryopteris filix-mas 1OO.O Thymus serpyllum 73.6 Echinacea purpurea 84.2 Thymus serpyllum 74.9 Echinacea purpurea 83.2 Thymus vulgaris 35.6 Erigeron speciosus (Lindl.) D.C. 46.1 Thymus vulgaris 66.6 Fagopyrun esculentum 27.5 Thymus vulgaris "Argenteus” 73.9 Filipendula rubra 59.6 Triticum turgidium ?? 21.6 Galinsoga ciliata (Rofiresque) 20.5 Vaccinium augustifolium 26.1 Blake Vaccinum Corymbosum 95.7 Galium odoratum 56.8 Vaccinium macrocarpon 46.1 Gaultheria hispidula (L) Muhl 1OO.O Valerianella locusta 96.O Glycine max 22.8 Veronica officinalis 26.4 Glycyrrhiza glabra 28.4 Viburnum trilobum Marsh. 25.0 Hamamelis virginiana 33.8 Vicia Satiya 28.2 Hamamelis virginiana 1OO.O Vicia villosa 34.5 Helianthus annus 26.5 Vitia sp. 26.O Helianthus Strunosus 21.2 Vitia sp. 41.6 Helianthus tuberosus L. 48.4 Vitia sp. 1OO.O Helichrysum angustifolium 38.1 Vitia sp. 30.8 Helichrysum angustifolium 83.8 Vitia sp. 22.3 Helichrysum thianschanicum Regel 61.3 US 2004/0175439 A1 Sep. 9, 2004 53

TABLE 7-continued TABLE 7-continued

Cath G Cath G Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Heliotropium arborescens G O 56.2 RoSmarinus officinalis G V 72.2 Heliotropium arborescens G R 54.9 Rubus canadensis G S 25.3 Huniulus lupulus G V 70.5 Rubus idaeus L. G W 31.1 Huniulus lupulus G S 43.O Levisitectum officinale G W 39.6 Hypericum henryi G O 31.O Matricaria recutita G O 1OO.O Hypericum perforatum G R 1OO.O Melissa officinalis G W 98.0 Inula helenium G W 85.3 Melissa officinalis G V 76.3 Inula helenium G V 74.7 Melissa officinalis G R 36.6 Inula helenium G S 37.4 Melissa officinalis G O 80.6 Ipomea batatas G O 39.0 Mentha arvensis G O 83.5 Satistinctoria G O 1OO.O Mentha piperita G O 79.0 Laportea Canadensis G O 26.9 Mentha piperita vulgaris G V 45.9 Laurus nobilis G W 51.5 Mentha pullegium G O 47.O Laurus nobilis G S 1OO.O Mentha Spicata G V 73.9 Lavendula angustifolia G V 44.4 Mentha Spicata G O 813 Lavendula latifolia G V 44.8 Mentha Spicata G O 93.0 Ledum groenlandicum G S 1OO.O Monarda didyma G S 35.8 Brassica napus G R 32.9 N G R 1OO.O Brassica napus G S 33.5 Salvia Officinalis G V 52.5 Brassica oleracea G S 1OO.O Salvia Officinalis G O 1OO.O Calamintha nepeta G V 51.5 Salvia Officinalis G R 38.8 Calendula officinalis L G O 26.7 Salvia Officinalis G V 49.5 Canna edulis G O 20.6 Salvia Officinalis G W 95.3 Chaerophyllum bulbosum G O 37.O Salvia Officinalis G W 41.3 Chaerophyllum bulbosum G V 88.6 Saivia Sciarea G W 31.1 N G R 34.8 Sarriette commune G O 59.7 Nepeta cataria G V 38.4 Sarriette vivace G O 72.3 Ocinum basilicum G W 20.4 Sarriette vivace G S 26.0 Ocinum basilicum G O 89.9 Satureia montana G V 78.5 Ocinum basilicum G V 31.3 Satureia montana G W 1OO.O Ocinum basilicum G W 82.3 Soianum tuberosum G O 35.8 Oenothera biennis linné G O 62.8 Sonchus oleraceus L G O 41.O Oenothera biennis linné G R 1OO.O Sorghum dochna G S 1OO.O Oenothera biennis linné G R 1OO.O Sorghun Sudanense G O 32.6 Oenothera biennis linné G S 1OO.O Sorghun Sudanense G W 39.7 Origanum vulgare G V 67.1 Symphytum officinale G V 79.4 Origanum vulgare G V 65.5 Symphytum officinale G O 74.6 Origanum vulgare G W 58.1 Tanacetum parthenium G V 23.1 Origanum vulgare G V 70.5 Tanacetum parthenium G W 24.3 Origanum vulgare G W 34.5 Tanacetum vulgare G W 20.8 Origanum vulgare G V 60.1 Tanacetum vulgare G O 32.O Origanum vulgare G O 1OO.O Tanacetum vulgare G O 58.5 Origanum vulgare G S 28.5 Tanacetum vulgare G V 44.8 Origanum vulgare G O 83.7 “Goldsticks' Origanum vulgare G S 22.1 Taraxacum officinale G V 58.2 Oxyria digyna G V 57.7 Thymus fragantissuinus G R 39.9 Perilla frutescens G V 75.8 Thymus herba-barona G W 26.6 Peucedanum cervaria G R 37.5 Thymus herba-barona G V 35.7 Peucedanum cervaria G R 25.3 Thymus praecox subsp arctitus G O 78.0 Plantago major G O 31.7 Thymus Serpyllum G V 47.4 Plectranthus sp. G V 28.5 Thymus Serpyllum G O 1OO.O Portulaca oleracera linné G O 37.8 Thymus Serpyllum G W 22.6 Potentilla anSerina G S 21.1 Thymus Serpyllum G V 70.2 Poterium Sanguisorba G V 72.1 Thymus vulgaris G O 40.8 Poterium Sanguisorba G S 65.9 Thymus vulgaris G W 37.3 Poterium Sanquisorba G O 63.6 Thymus vulgaris "Argenteus” G V 87.7 Poterium Sanquisorba G W 28.7 Thymus x citriodorus G W 27.2 Prunella vulgaris G O 40.7 Vaccinium angustifolium G S 41.7 Pteridium aquilinum G O 25.7 Vaccinium macrocarpon G W 63.5 Pteridium aquilinum G R 1OO.O Viburnum trilobum Marsh. G R 67.7 Raphanus Raphanistrum G R 42.7 Viburnum trilobum Marsh. G W 23.6 Ribes nidigrolaria G W 45.9 Vicia Satiya G O 38.5 Ribes nigrum G W 35.9 Rubus ideaus G S 1OO.O Ribes SilveStris G W 34.9 Rubus ideaus G R 37.6 Ribes Uva-crispa G S 30.5 Rubus ideaus G O 34.8 Ricinius communis G R 95.0 Rubus occidentalis G S 93.3 Ricinius communis G S 48.3 Rubus occidentalis G O 22.7 Rosa rugOSa thunb. G W 40.3 Rubus occidentalis G S 21.6 Rosa rugOSa thunb. G S 97.8 Rumex crispus linné G R 1OO.O RoSmarinus officinalis G O 1OO.O Rumex crispus linné G R 1OO.O RoSmarinus officinalis G R 54.1 Salvia elegens G V 41.3 RoSmarinus officinalis G W 77.7 Salvia elegens G W 62.9 US 2004/0175439 A1 Sep. 9, 2004 54

TABLE 7-continued TABLE 7-continued

Cath G Cath G Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Salvia Officinalis 43.3 Fragaria 42.7 Salvia Officinalis 55.1 Fragaria x ananassa 1OO.O Salvia Officinalis 1OO.O Fragaria x ananassa 1OO.O Alchemilia mollis 98.8 Fruit de la passion 30.2 Alchemilia mollis 24.3 Fucus vesiculosis 93.3 Alchemilia mollis 83.7 Galinsoga ciliata (Rofiresque) 33.O Alchemilia mollis 8O.O Blake. Althaea officianalis 34.1 Galium odoratum 27.0 Althaea officinalis 34.3 Gaultheria hispidula (L) Muhl 1OO.O Althaea officinalis 30.8 Gaultheria procumbens 3O.O Ambrosia artemisiifolia linné 61.6 Gaultheria procumbens 1OO.O Ambrosia artemisiifolia linné 52.1 Glycine max Envy 20.1 Anelanchier Sanguinea x A. 38.6 Glycyrrhiza glabra 47.9 laevis Guizotia abyssinica 74.1 angelica archangelica 54.8 Guizotia abyssinica Anthenis tinctorium 67.7 Hamamelis virginiana Arachis hypogaea 85.1 Hamamelis virginiana Aralia nudicaulis 74.2 Helenium hoopesii ArctostaphyloS uva-ursi 98.8 Helenium hoopesii ArctostaphyloS uva-ursi 82.4 Helianthus annus Aronia prunifolia 27.3 Helianthus Strunosus 54 Artemisia draculus 2O2 Helianthus tuberosa Artemisia dracunius 37.2 Helianthus tuberosa Artemisia Ludoviciana 54.8 Helichrysum angustifolium Aster sp? 43.4 Helichrysum angustifolium i Aster sp? 99.9 Helichrysum angustifolium Ayperus esculentius 46.9 Helichrysum angustifolium Beta vulgaris 81.4 Helichrysum thianschanicum Regel Beta vulgaris 30.6 Heliotropium arborescens Betula glandulosa 58.2 Hibiscus cannabinus Borago officinalis 2O2 Huniulus lupulus Brassica iuncea 56.6 Huniulus lupulus 5 Brassica napus 34. Huniulus lupulus Brassica nigra 32.3 Huniulus lupulus ss Brassica rapa Hypericum perforatum 1OO.O Calamintha nepeta Inula helenium 97.1 Calamintha nepeta Citrus innettoides 28.9 Canna edulis Citrus innon 25.9 Canneberge Citrus innon 43.3 Capsella bursa-pastoris (linné)medicus Coix Lacryma-Jobi 22.1 Carya cordiformis Coriandrum Sativum 62.O Chaerophyllum bulbosum Crataegus sp? 44.0 Chrysanthemum leucanthemum linné Crataegu.S. Subnois 40.7 Cichorium intybus Crataegu.S. Subnois 29.3 Cichorium intybus Curcuna longa syn. C. domestica 22.2 Cichorium intybus Cynara Scolynus 42.2 Cinicifuga racenOSa DioScorea batatas 29.1 Citrulius colocynthus DioScorea batatas 28.9 Citrus innettoides DioSpiros Kaki 57.8 Vicia villosa Dirca palustris 39.2 Vitia sp. Dolichus labiab 42.9 Vitia sp. Dryopteris filix-mas 24.9 Vitia sp. Dryopteris filix-mas 1OO.O Vitia sp. Echinacea purpurea 78.9 Zea mayS Melissa officinalis 36.0 Perilla frutescens Melissa officinalis 35.8 Perilla frutescens Melissa officinalis 1OO.O Perilla frutescens Melissa officinalis 30.3 Achillea millefolium mentha arvensis 67.2 Achillea millefolium Mentha piperita 20.8 Acorus Caianus Mentha piperita 1OO.O Acorus Caianus Mentha piperita 26.9 Adiantum pedatun Mentha piperita 97.8 Agastache foeniculum Mentha piperita vulgaris 2O2 Agastache foeniculum "Snow Pike' Mentha piperita vulgaris 42.5 Agastache foeniculum "Snow Pike' Mentha pullegium 1OO.O Agrinonia eupatoria Mentha Spicata 51.6 Alchemilia mollis Mentha Spicata 81.8 Alchemilia mollis Mentha Spicata 1OO.O Echinacea purpurea Mentha Spicata 1OO.O Echinacea purpurea Mentha Spicata 23.2 Erigeron speciosus (Lindl.) D.C. Nepeta cataria 62.8 US 2004/0175439 A1 Sep. 9, 2004 55

TABLE 7-continued TABLE 7-continued

Cath G Cath G Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Ocinum Basilicum T V 41.1 Rubus idaeus L. T S 1OO.O Ocinum Basilicum T W 40.O Rubus ideaus T S 46.1 Ocinum Basilicum T O 28.4 Rubus ideaus T R 32.O Oenothera biennis linné T O 67.3 Rubus ideaus T O 28.5 Oenothera biennis linné T R 1OO.O Rubus occidentalis T R 1OO.O Onobrychis viciafolia T O 34.O Rubus occidentalis T O 23.5 Origanun nationara T O 29.5 RuneS Scutatus T O 27.1 Origanum vulgare T V 55.5 Rumex acetosella linné T O 23.O Origanum vulgare T W 67.7 Pastinaca Satiya T R 22.2 Origanum vulgare T W 46.4 Petroselinum crispun Nyman ex. T W 24.8 Origanum vulgare T V 68.6 A. WHII Origanum vulgare T W 99.9 Peucedanum cervaria T R 53.0 Origanum vulgare T V 42.O Peucedanum cervaria T R 35.9 Origanum Vulgare T V 28.8 Pfafia paniculata T O 85.9 Origanum Vulgare T W 46.7 Phaseolus vulgaris T O 35.7 Origanum vulgare T O 1OO.O Phytolacca americana T S 28.6 Origanum vulgare T W 51.7 Phytolacca decandra syn. T O 31.6 Origanum vulgare T S 30.8 Pannericana Origanum vulgare T O 25.4 Plectranthus sp. T V 66.O Origanum vulgare T S 38.2 Polygonium chinense T S 33.2 Oxyria digyna T V 23.1 Polygonum aviculare linné T R 1OO.O Pastinaca Satiya T O 33.1 Populus X petrowskyana T O 25.4 Inula helenium T W 69.0 Potentilla anSerina T S 55.8 Inula helenium T S 29.3 Poterium Sanguisorba T W 1OO.O Ipomea bataiaS T O 27.0 Poterium Sanguisorba T V 82.3 Iris versicolor T R 22.9 Prunella vulgaris T O 52.6 Juniperus Communis T R 1OO.O Psoralea corylifolia T O 21.3 Kranneria Triandra T O 52.6 Psoralea corylifolia T S 26.0 Lathyrus Sylvestris T R 32.5 Psoralea corylifolia T S 27.4 Laurus nobilis T S 1OO.O Pteridium aquilinum T R 1OO.O Lavendula angustifolia T V 74.8 Punica granatun T V 21.3 Lavendula angustifolia T W 70.2 Punica granatun T W 77.1. Lavendula latifolia T W 85.6 Punica granatun T S 43.9 Lavendula latifolia T V 6.3.3 Satureia repandra T R 35.8 Lavendula latifolia T O 2O2 Satureia repandra T W 1OO.O Ledum groenlandicum T R 1OO.O Satureia repandra T V 75.0 Ledum groenlandicum T S 94.1 Soianum Tuberosum T O 30.9 Lepidium Sativum T O 20.5 Solidago Canadensis T R 91.8 Litchi chinensis T S 1OO.O Sonchus oleraceus L. T O 45.9 Lolium multiflorum T O 22.7 Sorghum dochna Snowdrew T O 31.5 Lonicera ranosissina T S 30.9 Sorghun Sudanense T O 33.6 Lotus corniculatus T R 6O2 Stipa capiliata L T O 33.O Malus T V 23.1 Symphytum officinale T O 94.1 Maiva noSchata T S 31.4 Symphytum officinale T O 42.8 Melissa officinalis T V 81.4 Tanacetum parthenium T W 40.1 Melissa officinalis T W 87.5 Tanacetum parthenium T V 33.6 Melissa officinalis T O 1OO.O Tanacetum vulgare T V 36.5 Radix Rehmannia T O 23.9 Tanacetum vulgare T W 51.2 Raphanus raphanistrum T R 36.5 Tanacetum vulgare T O 95.6 Raphanus raphanistrum T R 30.5 Tanacetum vulgare T O 38.4 Rhamnus franguia T R 1OO.O Tanacetum vulgare T R 27.4 Rheum palmatum T W 1OO.O Tanacetum vulgare T V 37.9 Rianus communis T R 1OO.O “Goldsticks' Rianus communis T S 1OO.O Taraxacum officinale T V 57.8 Rianus communis T S 68.2 Thymus fragantissuinus T R 34.O Ribes GroSSularia L T W 61.1 Thymus fragantissuinus T W 72.7 Ribes nidigrolaria T W 32.1 Thymus fragantissuinus T V 71.0 Ribes nigrum T O 90.2 Thymus praecox subsp arctitus T O 59.2 Ribes nigrum T S 20.3 Thymus pseudoianuginosus T O 85.7 Ribes nigrum L. T W 21.1 Thymus pseudoianuginosus T W 2O.9 Ribes nigrum L. T W 51.6 Thymus Serpyllum T O 94.8 Ribes sativam Syme T W 2O.9 Thymus Serpyllum T W 38.4 Ribes uva-crispa T S 4.1.8 Thymus vulgaris T O 1OO.O Rosa rugosa T S 1OO.O Thymus vulgaris "Argenteus” T V 80.4 Rosa rugOSa thunb. T W 94.1 Thymus X citriodorus T O 1OO.O RoSmarinum officinalis T O 1OO.O Tiarella cordifolia T R 1OO.O RoSmarinum officinalis T R 40.O TrichoSanthes kirillowii T O 1OO.O RoSmarinum officinalis T V 76.9 Triticale sp. T O 24.4 Rubus Canadensis T S 31.3 Tropaeoium nails T O 20.6 Rubus Canadensis T V 22.8 Rumex crispus linné T R 1OO.O Rubus Canadensis T W 1OO.O Rumex crispus linné T R 1OO.O Rubus idaeus T V 25.0 Salvia (elegens) T O 1OO.O US 2004/0175439 A1 Sep. 9, 2004 56

TABLE 7-continued TABLE 8-continued

Cath G Cath L Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Salvia elegens 63.5 Allium TuberoSun 69.5 Salvia Officinalis 34.O Aloe vera 44.7 Salvia Officinalis 41.7 Aloe vera 55.6 Salvia Officinalis 64.3 Althaea officinalis 95.0 Salvia Officinalis 1OO.O Althaea officinalis 33.4 Salvia Officinalis 38.8 Amaranthus retroflexus 745 Salvia Officinalis 73.4 Amaranthus retroflexus 98.4 Salvia Officinalis 95.3 Anethum graveolens 37.4 Salvia Officinalis 56.8 Anethum graveolens 58.7 Salvia Officinalis 25.1 Angelica archangelica 79.1 Saivia Sciarea 28.6 Apium graveolens 27.9 Sambucus Canadensis 40.1 Apium graveolens 46.5 Sambucus Canadensis L. 50.2 Aralia nudicaulis 89.3 Sambucus Caradensis 29.7 Aralia nudicaulis 55.4 Sanguisorba minor 32.O Arctium lappa 32.8 Sanguisorba minor 59.5 Arctium minius 72.5 Sanguisorba minor 58.5 Arctium minius 61.3 Sanguisorba minor 68.5 Arnoracia rusticana 95.8 Satureia hortensis 66.5 Aronia melanocarpa 39.8 Satureia hortensis 20.1 Aronia melanocarpa 28.2 Satureia montana 43.3 Artemisia Absinthium 51.7 Satureia montana 36.7 Artemisia Absinthium 63.7 Satureia montana 1OO.O Artemisia dracunculus 45.4 Satureia montana 81.1 Aster sp 4.1.8 Satureia montana 40.6 Aster sp 91.5 Satureia montana 54.O Atropa belladonna 47.3 Satureia montana 90.1 Atropa belladonna 31.7 Ulmus annericana 43.7 Cyperus esculentius 41.3 Urtica dioica 28.9 Cyperus esculentus 33.8 Vaccinium angustifolium 43.2 Beckmannia eruciformis 40.5 Vaccinium angustifolium 42.4 Beckmannia eruciformis 60.8 Vaccinium macrocarpon 59.2 Beta vulgaris 66.1 Vaccinium macrocarpon 27.2 Beta vulgaris 79.5 Vaccinium macrocarpon 21.6 Beta vulgaris spp. Maritima 6.3.3 Vaccinium macrocarpon 62.6 Beta vulgaris spp. Maritima 59.1 Veronica officinalis 52.6 Borago officinalis 40.9 Viburnum trilobum Marsh. 1OO.O Brassica napus 64.6 Vicia villosa 36.6 Brassica napus 21.1 Vitia sp. 58.9 Brassica oleracea 66.6 Vitis sp 24.7 Brassica oleracea 68.6 Vitis sp. 22.8 Brassica rapa 89.0 Vitis sp. 21.7 Brassica rapa 99.3 Zea mayS 20.5 CapSella bursa-pastoris 47.O Capsicum annuum 29.1 Carium carvi 60.4 Chaerophyllum bulbosum 48.6 Chaerophyllum bulbosum 48.2 0152) Chelidonium maius 35.5 Chelidonium maius 23.1 TABLE 8 Chenopodium bonus-henricus 65.9 Chenopodium quinoa 62.3 Cath L Chenopodium quinoa 9O.O Cicer arietinium 82.4 Nom latin Stress Extrait Inhibition (%) Cichorium intybus 58.0 Cichorium intybus 81.7 Actinidia arguta 6.3.3 Coix Lacryma-Jobi 32.6 Actinidia arguta 46.3 Coix Lacryma-Jobi 43.4 Achillea millefolium 32.4 Coriandrum Sativum 26.9 Achillea millefolium 26.3 Coriandrum Sativum 65.O Aconitun napeius 3O.O Cornus Canadensis 99.7 Acorus Caianus 25.9 Cornus Canadensis 60.6 Adiantum pedatun 2O2 Crataegus sp 25.9 Adiantum pedatun 22.2 Crataegus sp 28.2 Agropyron repenS 98.6 Cryptotaenia Canadensis 73.3 Agropyron repenS 618 Cryptotaenia Canadensis 36.1 Alchemilia mollis 75.7 Cymbopogon citratus 32.7 Alchemilia mollis 36.5 Daucus Carota 63.6 Allium porrum 39.7 Daucus Carota 43.4 Allium porrum 58.2 Dirca palustris 61.1 Allium cepa 51.O Dirca palustris 46.6 Allium Sativum 53.8 Echinacea purpurea 54.8 Allium SchoenopraSun 74.6 Eleusine Coracana 36.4 US 2004/0175439 A1 Sep. 9, 2004 57

TABLE 8-continued TABLE 8-continued

Cath L Cath L Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Fagopyrun eSculentum A. R 37.9 Phaiaris canariensis A. R 45.4 Fagopyrun eSculentum A. O 43.3 Phaseolus vulgaris A. R 31.0 Fagopyrun tataricum A. R 28.4 Phaseolus Vulgaris A. O 618 Fagopyrun tataricum A. O 32.8 Pimpinella anisum A. O 38.1 Foeniculum vulgare A. O 48.8 Plantago major A. O 95.1 Fragaria x ananassa A. R 46.3 Plectranthus sp. A. R 76.9 Fragaria x ananassa A. O 78.8 Plectranthus sp. A. O 58.0 GainSoga ciliata A. O 46.0 Polygonum aviculare A. R 28.0 Galium odoratum A. R 59.8 Polygonum aviculare A. O 49.7 Galium odoratum A. O 79.5 Potentilla anSerina A. R 26.6 Gaultheria hispidula A. R 53.4 Poterium Sanquisorba A. O 58.0 Gaultheria hispidula A. O 54.3 Pteridium aquilinum A. R 32.9 Giechona hederacea A. O 23.4 Raphanus raphanistrum A. R 70.7 Giechona hederacea A. R 26.8 Raphanus raphanistrum A. O 83.2 Glycine max A. R 20.5 Raphanus Saiivus A. R 90.9 Glycine max A. O 73.8 Raphanus Sativus A. O 95.4 Glycyrrhiza glabra A. O 57.7 Ipomoea Batatas A. O 29.6 Glycyrrhiza glabra A. R 53.8 Lathyrus Sativus A. R 31.7 Guizotia abyssinica A. R 29.6 Lathyrus Sativus A. O 71.1 Guizotia abyssinica A. O 78.6 Lathyrus Sylvestris A. R 65.3 Hamamelis virginiana A. R 41.2 Rosa rugosa A. O 35.9 Hedeoma pullegioides A. O 26.3 RoSmarinus officinalis A. O 78.2 Helleborus niger A. O 36.9 Rubus allegheniensis A. O 76.8 Helleborus niger A. R 35.4 Rubus canadensis A. R 40.7 Hordeum hexaStichon A. R 31.1 Rubus canadensis A. O 72.6 HySSopus officinalis A. R 84.8 Rubus idaeus A. R 35.5 HySSopus officinalis A. O 85.8 Rubus idaeus A. O 97.9 Inula helenium A. O 58.4 Runnex Acetosa A. O 32.O Inula helenium A. R 32.7 Runnex acetoSella A. R 73.2 Campanula rapunculus A. R 59.0 Runnex acetoSella A. O 56.9 Campanula rapunculus A. O 50.6 Rumex crispus A. R 49.7 Canna edulis A. O 23.9 Rumex crispus A. O 37.5 CapSella bursa-pastoris A. R 49.0 Runnex Sciutatus A. O 53.1 Lathyrus Sylvestris A. O 66.4 Runnex Sciutatus A. R 25.9 Laurus nobilis A. R 43.1 Ruta graveolens A. O 56.2 Laurus nobilis A. O 46.1 Salix purpurea A. R 71.4 Leonurus cardiaca A. O 6.3.3 Salix purpurea A. O 24.7 Leonurus cardiaca A. R 24.5 Saivia elegans A. O 67.6 Levisticum officinale A. R 20.9 Salvia Officinalis A. O 70.5 Levisticum officinale A. O 43.8 Salvia Officinalis A. R 56.6 Lotus corniculatus A. R 69.0 Saivia Sciarea A. O 70.1 Lotus corniculatus A. O 87.4 Santolina Chamaecyparissus A. R 59.5 Lycopersicon eSculentum A. R 28.0 Santolina Chamaecyparissus A. O 59.2 Malva Sylvestris A. O 23.1 Satureia montana A. O 71.7 Medicago Sativa A. R 63.8 Scorzonera hispanica A. O 21.9 Medicago Sativa A. O 53.6 Secale cereale A. R 33.3 Melilotus albus A. O 93.7 Senecio vulgaris A. R 47.5 Melilotus albus A. R 80.1 Senecio vulgaris A. O 20.8 Melissa officinalis A. R 40.8 Setaria italica A. R 48.6 Melissa officinalis A. O 69.5 Setaria italica A. O 37.1 Mentha piperita A. R 61.O Sium Sisarium A. O 33.8 Mentha piperita A. O 73.2 Sium Sisarium A. R 62.5 Mentha pullegium A. O 69.0 Soianum tuberosum A. O 53.6 Mentha Spicata A. O 94.6 Solidago sp A. R 54.O Mentha Suaveolens A. O 55.2 Solidago sp A. O 95.1 Nepeta cataria A. R 45.9 Sonchus oleraceus A. R 59.4 Nepeta cataria A. O 66.3 Sonchus oleraceus A. O 69.2 Nicotiana tabacunn A. R 46.8 Sorghum dochna A. R 33.9 Oenothera biennis A. R 69.8 Sorghum dochna A. O 55.3 Oenothera biennis A. O 47.3 Sorghum durra A. R 61.3 Origanum majorana A. O 38.5 Sorghum durra A. O 83.9 Origanum vulgare A. R 43.3 Stachys byzantina A. R 61.6 Origanum vulgare A. O 68.2 Stachys byzantina A. O 73.8 Panax quinquefolius A. R 41.7 Stellaria graminea A. R 40.1 Panax quinquefolius A. O 83.7 Stellaria graminea A. O 55.8 Pastinaca Satiya A. O 62.8 Stellaria media A. R 70.9 Pastinaca Satiya A. R 44.2 Stellaria media A. O 51.4 Perilla frutescens A. O 66.2 Tanacetum cinerariifolium A. O 67.7 Petasites japonicus A. R 22.6 Tanacetum parthenium A. R SO.8 Petasites japonicus A. O 25.5 Tanacetum parthenium A. O 81.9 Petroselinum crispum A. O 79.1 Tanacetum vulgare A. R 56.2 Petroselinum crispum A. R 32.3 Tanacetum vulgare A. O 51.9 US 2004/0175439 A1 Sep. 9, 2004 58

TABLE 8-continued TABLE 8-continued

Cath L Cath L Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Taraxacum officinale A. O 98.7 Aster sp G R 48.7 Taraxacum officinale A. R 82.1 Aster sp G O 94.5 Teucrium chamaedrys A. O 62.2 Atropa belladonna G R 29.2 Rheum rhabarbarium A. R 26.0 Beckmannia eruciformis G O 32.9 Rheum rhabarbarium A. O 62.9 Beta vulgaris G R 47.9 Ribes nigrum A. O 62.9 Beta vulgaris G O 61.9 Ribes Sylvestre A. R 34.5 Borago officinalis G O 51.9 Ribes Sylvestre A. O 80.3 Brassica Napus G O 92.1 Ricinius communis A. R 89.9 Brassica napus G R 30.2 Ricinius communis A. O 81.0 Brassica oleracea G R 79.0 Rosa rugosa A. R 32.9 Brassica oleracea G O 85.4 Tragopogon porrifolius A. O 67.2 Brassica rapa G O 81.7 Tragopogon porrifolius A. R 37.O Caianagrostis arundiflora G R 59.7 Tropaedium maius A. O 62.8 Campanula rapunculus G R 65.4 Typha latifolia A. R 77.5 Campanula rapunculus G O 54.8 Typha latifolia A. O 7O6 Canna edulis G O 3O.O Vaccinium Corymbosum A. O 74.7 CapSella bursa-pastoris G R 48.1 Vaccinium Corymbosum A. R 69.5 CapSella bursa-pastoris G O 50.9 Vaccinium macrocarpon A. R 71.4 Tropaeoium nails G R 22.2 Vaccinium macrocarpon A. O 78.9 Tropaeoium nails G O 59.1 Verbascum thapsus A. O 76.8 Carium carvi G O 62.4 Verbascum thapsus A. R 62.O Cerastium tonentOSun G R 45.1 Vicia Satiya A. R 79.2 Chaerophyllum bulbosum G O 3O.O Vicia Satiya A. O 88.7 Chaerophyllum bulbosum G R 54.5 Vicia villosa A. O 745 Chelidonium maius G O 43.2 Vicia villosa A. R 61.O Chelidonium maius G R 30.7 Vinca minor A. O 46.7 Chichorium endivia G O 64.2 Vinca minor A. R 31.9 Chichorium endivia subsp G R 48.3 Vitis sp. A. R 89.5 endivia Vitis sp. A. O 54.6 Chichorium endivia subsp G O 67.O Zea mayS A. R 52.0 endivia Zea mayS A. O 93.8 Cichorium intybus G O 78.3 Achillea millefolium G O 45.8 Cichorium intybus G R 87.8 Achillea millefolium G R 24.6 Circium arvense G R 94. Aconitun napeius G R 28.7 Circium arvense G O 58.7 Acorus Caianus G R 37.5 Coix Lacryma-Jobi G R 35.7 Acorus Caianus G O 32.8 Coix Lacryma-Jobi G O 31.4 Actinidia arguta G R 47.8 Cornus Canadensis G R 61.3 Actinidia arguta G O 78.4 Conus Canadensis G O 80.6 Adiantum pedatun G O 45.9 Crataegu.S. Subnois G R 21.0 Adiantum pedatun G R 27.0 Crataegu.S. Subnois G O 44.4 Agropyron repenS G O 83.O Cymbopogon citratus G R 39.6 Agropyron repenS G R 31.9 Cyperus esculentius G R 624 Alchemilia mollis G O 71.0 Cyperus esculentius G O 49.6 Allium anpeiopraSun G R 36.8 Daucus Carota G O 36.3 Allium anpeiopraSun G O 62.2 Daucus Carota G R 44.3 Allium cepa G R 56.1 Dirca palustris G O 85. Allium cepa G O 64.4 Dirca palustris G R 47. Allium Sativum G O 65.2 Echinacea purpurea G O 36.4 Allium SchoenoporaSun G O 78.4 Eleusine Coracana G O 65.4 Allium tuberoSun G O 46.6 Eleusine Coracana G R 36.8 Aloe vera G O 45.7 Aralia nudicaulis G O 71.8 Althaea officianalis G O SO.O Aralia nudicaulis G R 38.2 althaea officinalis G R 42.2 Arctium minius G R 42.4 Amaranthus retroflexus G R 41.7 Arctium minius G O 41.5 Amaranthus retroflexus G O 90.3 Arnoracia rusticana G O 67. Anethum graveolens G R 31.3 Aronia melanocarpa G R 32.O Anethum graveolens G O 60.5 Aronia melanocarpa G O 7O.O Angelica archangelica G O 64.3 Artemisia absinthium G R 63. Angelica archangelica G R 6.3.3 Artemisia absinthium G O 61. Apium graveolens G O 57.0 Asclepias incanata G R 58.4 Apium graveolens G R 28.4 Asclepias incarnata G O 6.3.3 Thymus praecox subsp arcticus A. R 42.O Asparagus Officinalis G R 61.2 Thymus praecox subsp arcticus A. O 54.2 Gaultheria hispidula G O 50.6 Thymus serpyllum A. O 93.4 Gaultheria procumbens G R 53.3 Thymus serpyllum A. R 57.5 Gaultheria procumbens G O 67.7 Thymus vulgaris A. R 68.7 Giechona hederacea G O 70.9 Thymus vulgaris A. O 55.8 Giechona hederacea G R 25.3 Thymus x citriodorus A. O 72.8 Glycine max G R 78.6 Thymus x citriodorus A. R 31.9 Glycine max G O 85.9 Asparagus Officinalis G O 86.3 Glycyrrhiza glabra G R 59.1 Aster linné G O 57.5 Glycyrrhiza glabra G O 60.6 US 2004/0175439 A1 Sep. 9, 2004 59

TABLE 8-continued TABLE 8-continued

Cath L Cath L Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Guizotia abyssinica G R 4.1.8 Pimpinella anisum G O 86.2 Guizotia abyssinica G O 74.3 Pisun Stativum G O 61.6 Hamamelis virginiana G R 44.2 Pisun Stativum G R 57.5 Helianthus Strunosus G O 40.6 Plantago major G O 91.9 Helianthus Strunosus G R 61.4 Plectranthus sp. G R 53.0 Helianthus tuberosus G O 75.1 Plectranthus sp. G O 73.O Helianthus tuberosus G R 30.1 Polygonum aviculare G R 32.2 Helichrysum thianschanicum G R 56.3 Polygonum aviculare G O 36.4 Helichrysum thianschanicum G O 84.O Portulaca oleracea G R 82.1 Helleborus niger G O 38.8 Portulaca oleracea G O 6.3.3 Helleborus niger G R 25.9 Potentilla anSerina G R 26.3 Hordeum hexaStichon G O 62.3 Poterium Sanquisorba G O 79.9 Hordeum hexaStichon G R 29.4 Prunella vulgaris G R 68.8 HySSopus officinalis G R 64.7 Prunella vulgaris G O 57.4 HySSopus officinalis G O 71.9 Raphanus Raphanistrum G R 91.9 Inula helenium G O 29.4 Raphanus Raphanistrum G O 55.2 Inula helenium G R 25.7 Rhaphanus Sativus G R 55.7 Ipomoea batatas G O 36.9 Rhaphanus Sativus G O 78.4 Lactuca Sativa G O 70.4 Rheum rhabarbarium G R 27.1 Lactuca Sativa G R 49.9 Rheum rhabarbarium G O 56.8 Lathyrus Sativus G O 62.8 Ribes nidigrolaria G O 70.7 Lathyrus Sativus G R 29.0 Ribes nigrum G R 37.9 Lathyrus Sylvestris G R 52. Ribes nigrum G O 98.9 Lathyrus Sylvestris G O 52.5 Ribes Sylvestris G R 25.2 Laurus nobilis G R 27. Ribes Sylvestris G O 65.7 Laurus nobilis G O 61.O Maius hupehensis G R 52.7 Lavandula angustifolia G R 51.9 Maius hupehensis G O 64.1 Lavandula angustifolia G O 57.0 Malva Sylvestris G R 26.2 Ledum groenlandicum G O 73.4 Medicago Sativa G R 43.4 Ledum groenlandicum G R 52.6 Medicago Sativa G O 92.5 Leonurus cardiaca G O 88.8 Malilotus aibus G R 75.5 Leonurus cardiaca G R 38.5 Melilotus albus G O 7O.O Levisitectum officinale G R 51.2 Melissa officinalis G O 81.1 Levisitectum officinale G O 78.3 Mentha piperita G O 54.4 Lotus corniculatus G O 86.8 Mentha pullegium G O 59.4 Lotus corniculatus G R 50.3 Mentha Spicata G R 38.8 Lupinus polyphyllius G R 78.9 Mentha Spicata G O 83.O Lupinus polyphyllius G O 66.7 Mentha Suaveolens G O 56.5 Erigeron Speciosus G R 39.1 Nepeta cataria G O 56.2 Erysimum perofskianum G R 58.7 Ocinum basilicum G O 603 Erysimum perofskianum G O 93.1 Oenothera biennis G R 39.2 Fagopyrun eSculentum G R 36.4 Santolina Chamaecyparissus G R 61.3 Fagopyrun eSculentum G O 41.O Santolina Chamaecyparissus G O 88.2 Fagopyrun tataricum G R 43.3 Saponaria Officinalis G R 52.9 Fagopyrun tataricum G O 29.1 Saponaria Officinalis G O 71.8 GainSoga ciliata G R 49.8 Satureia hortensis G O 44.9 GainSoga ciliata G O 58.0 Satureia montana G O 76.8 Galium odoratum G R 65.1 Scorzonera hispanica G R 32.9 Galium odoratum G O 94.2 Scuttellaria lateriflora G O 49.8 Gaultheria hispidula G R 55.7 Scuttellaria lateriflora G R 39.6 Oenothera biennis G O 44.3 Secale cereale G R 37.O Origanum majorana G O 44.7 Senecio vulgaris G R 31.0 Origanum vulgare G O 58.1 Senecio vulgaris G O 47.O Origanum vulgare G R 22.9 Setaria italica G R 44.9 Oryza Sativa G R 71.8 Setaria italica G O 42.O Oryza Sativa G O 39.8 Silene vulgaris G R 76.8 Oxalis Deppei G R 80.1 Silene vulgaris G O 92.2 Oxalis Deppei G O 28.8 Shan Sisarun G O 58.9 Oxyria digyna G R 51.8 Sium Sisarun G R 66.6 Oxyria digyna G O 36.2 Soianum melongena G R 66.8 Panax quinquefolius G R 72.1 Solarium tuberoSun G O 47.4 Panax quinquefolius G O 81.6 Solidago sp G R 53.6 Panicum miliaceum G O 93.4 Solidago sp G O 88.3 Passiflora caerula G R 33.2 Sonchus oleraceus G R 62.5 Passiflora caerula G O 63.2 Sonchus oleraceus G O 55.5 Pastinaca Satiya G O 54.O Sorghum dochna G R 67.4 Pennisetum alopecuroides G R 61.O Sorghum dochna G O 73.7 Petasites japonicus G O SO.O Sorghun durira G R 24.8 Petroselinum crispum G R 49.1 Sorghun durira G O 423 Petroselinum crispum G O 52.2 Sorghun Sudanense G R 35.5 Phaiaris canariensis G O 72.1 Sorghun Sudanense G O 66.3 Phaseolus vulgaris G R 21.8 Stachys byzantina G R 75.5 US 2004/0175439 A1 Sep. 9, 2004 60

TABLE 8-continued TABLE 8-continued

Cath L Cath L Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Stachys byzantina G O 66.7 Taraxacum officinale G R 78.6 Stellaria graminea G R 36.9 Teucrium chamaedrys G O 50.5 Stellaria graminea G O 40.1 Teucrium chamaedrys G R 40.1 Stellaria media G R 31.2 Thymus fragantissinus G R 81.4 Stellaria media G O 51.1 Thymus fragantissinus G O 58.4 Symphytum officinale G R 90.2 Thymus praecox subsp arcticus G R 49.2 Symphytum officinale G O 90.8 Thymus praecox subsp arcticus G O 62.4 Tanacetum cinerariifolium G O 76.1 Thymus Serpyllum G O 70.4 Tanacetum parthenium G R 70.1 Thymus Serpyllum G R 54.9 Tanacetum parthenium G O 62.4 Thymus vulgaris G R 55.1 Tanacetum vulgare G R 36.2 Thymus x citriodorus G O 47.1 Tanacetum vulgare G O 72.5 Tiarella cordifolia G O 52.8 Ricinius communis G R 39.3 Typha latifolia G R 65.1 Ricinius communis G O 84.3 Typha latifolia G O 46.9 RoSmarinus officinalis G O 68.6 Vaccinium corymbosum G O 54.5 Rubus idaeus G O 26.3 Vaccinium corymbosum G R 82.9 Rumex crispus G R 54.2 Vaccinium angustifolium G R 27.9 Rumex crispus G O 62.O Vaccinium angustifolium G O 66.8 Rumex Sciutatus G O 38.1 Vaccinium macrocarpon G R 40.7 Ruta graveolens G O 85.O Asclepias incanata T O 66.8 Salix purpurea G R 74.7 Aster spp T R 40.5 Salix purpurea G O 38.5 Aster spp T O 86.7 Saivia elegans G O 54.8 Atropa belladonna T O 61.4 Salvia Officinalis G R 89.7 Atropa belladonna T R 30.4 Salvia Officinalis G O 84.9 Avena Sativa T R 38.0 Saivia Sciarea G O 61.6 Cyperus esculentius T O 47.6 Sambucus ebulus G R 48.2 Cyperus esculentius T R 49.5 Sambucus ebulus G O 98.2 Beta vulgaris T O 62.2 Vaccinium macrocarpon G O 76.7 Borago officinalis T O 39.1 Veratrun viride G O 35.4 Brassica Napus T O 89.3 Verbascum thapsus G O 72.9 Brassica nigra T R 26.9 Verbascum thapsus G R 60.5 Brassica oleracea T O 63.9 Viburnum trilobum G R 52.6 Brassica oleracea T R 76.2 Vicia Satiya G R 36.6 Brassica oleracea T O 69.9 Vicia Satiya G O 83.2 Bronius inermis T R 79.8 Vicia villosa G O 77.3 Bronius inermis T O 88.1 Vicia villosa G R 46.8 Caianagrostis arundiflora in T R 62.8 Vinca minor G O 63.0 Calendula officinalis T R 64.6 Vinca minor G R 30.8 Canna edulis T O 47.5 Vitis sp. G R 52.7 CapSella bursa-pastoris T R 48.7 Vitis sp. G O 99.2 CapSella bursa-pastoris T O 40.9 Zea mayS G R 45.1 Carex morrowii T R 45.7 Zea mayS G O 55.3 Carex morrowii T O 70.3 Perilla frutescens T R 68.0 Carium carvi T R 22.7 Perilla frutescens T O 74.4 Cerastium tonentOSun T R 46.8 Achillea millefolium T O 46.0 Chaerophyllum bulbosum T R 22.9 Achillea millefolium T R 32.9 Chaerophyllum bulbosum T O 40.9 Aconitun napeius T O 35.2 Chelidonium maius T O 60.7 Aconitun napeius T R 31.9 Chelidonium maius T R 24.0 Acorus Caianus T O 40.6 Chenopodium quinoa T R 41.5 Acorus Caianus T R 26.9 Chenopodium quinoa T O 86.7 Actinidia arguta T R 8O.O Cicer arietinium T R 20.4 Actinidia arguta T O 66.3 Cicer arietinium T O 84.2 Adiantum pedatun T O 43.4 Cichorium endivia T O 76.3 Agrinonia eupatoria T O 37.5 Cichorium intybus T O 81.7 Agropyron repenS T O 75.O Cichorium intybus T R 73.3 Agropyron repenS T R SO.O Circium arvense T R SO.O Alchemilia mollis T O 71.6 Circium arvense T O 74.8 Alchemilia mollis T R 81.1 Anaranthus candatus T O 6O.O Allium anpeiopraSun T O 84.4 Amaranthus retroflexus T R 33.2 Allium cepa T O 49.2 Amaranthus retroflexus T O 94.3 Allium cepa T R 30.1 angelica archangelica T O 37.4 Allium Sativum T O 63.8 angelica archangelica T R 55.7 Allium SchoenopraSun T O 79.6 Anthriscus cerefolium T O 86.5 Allium tuberoSun T O 55.8 Anthriscus cerefolium T R 69.6 Allium tuberoSun T R 29.6 Apium graveolens T R 22.0 Aloe vera T R 30.3 Aralia nudicaulis T O 77.5 Aloe vera T O 42.7 Aralia nudicaulis T R 28.4 Althaea officinalis T R 42.5 Arctium minius T R 54.4 Althaea officinalis T O 46.3 Arctium minius T O 89.5 Anaranthus candatus T R 37.3 Arnoracia rusticana T O 84.9 Taraxacum officinale G O 1OO.O Aronia melanocarpa T R 61.9 US 2004/0175439 A1 Sep. 9, 2004 61

TABLE 8-continued TABLE 8-continued

Cath L Cath L Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Aronia melanocarpa 84.5 Medicago Sativa 41.O Artemisia absinthium 29.0 Medicago Sativa 94.1 Artemisia absinthium 55.9 Melilotus officinalis 44.0 Artemisia dracunculus 96.7 Melilotus officinalis 90.8 Artium lappa 26.0 Mentha piperita 20.6 Asclepias incanata 58.5 Menyanthes trifoliata 20.8 Fagopyrun tataricum 25.6 Miscanthus Sinensis 89.0 Foeniculum vulgare 79.0 Miscanthus Sinensis 73.7 Fragaria x ananassa 26.0 Nepeta cataria 25.3 GainSoga ciliata 34.6 Ocinum Basilicum 65.7 GainSoga ciliata 603 Oenothera biennis 40.2 Galium odoratum 98.8 Oenothera biennis 49.2 Galium odoratum 96.1 Onobrychis viciiafolia 53.2 Gaultheria hispidula 33.1 Onobrychis viciiafolia 49.2 Gaultheria procumbens 84.2 Origanum vulgare 50.6 Giechona hederacea 70.1 Origanum vulgare 45.1 Giechona hederacea 38.5 Oryza Sativa 40.3 Glycine max 54.8 Oryza Sativa 28.6 Glycine max 38.0 Oxalis Deppei 35.2 Glycine max 88.7 Oxalis Deppei 42.1 Glycyrrhiza glabra 65.5 Oxyria digyna 42.8 Glycyrrhiza glabra 40.5 Oxyria digyna 52.3 Guizotia abyssinica 48.1 Panax quinquefolius 78.8 Guizotia abyssinica 84.1 Panicum miliaceum 52.6 Hamamelis virginiana 35.9 Passiflora caerulea 77.5 Hedeoma pullegioides 24.8 Pastinaca Satiya 52.0 Helianthus Strunosus 32.9 Pastinaca Satiya 31.8 Helianthus Strunosus 31.0 Pennisetum alopecuroides 73.4 Helianthus tuberosus 42.8 Pertoselinum crispum 65.2 Helianthus tuberosus 72.1 Petasites Japonicus 31.3 Helichrysum angustifolium 69.6 Petasites Japonicus 24.6 Helichrysum angustifolium 84.9 Pertoselinum crispum 45.2 Helichrysum thianschanicum 96.2 Koeleria glauca 67.7 Helichrysum thianschanicum 80.7 Lactuca Sativa 75.2 Huniulus lupulus 71.3 Lactuca Sativa 55.3 Huniulus lupulus 60.6 Lathyrus Sativus 23.3 Hyoscyanus niger 68.0 Lathyrus Sativus 70.6 HySSopus officinalis 73.3 Lathyrus Sylvestris 77. HySSopus officinalis 76.9 Lathyrus Sylvestris 53.0 Inula helenium 93.3 Laurus nobilis 61.6 Inula helenium 63.5 Laurus nobilis 92.7 Ipomoea bataiaS 99.9 Lavandula angustifolia 54. Juniperus Communis 26.9 Lavandula angustifolia Kochia Scoparia. 76.7 Lavandula latifolia Koeleria glauca 89.1 Lavandula latifolia Citrulius colocynthus 62.5 Ledum groenlandicum Citrulius colocynthis 57.3 Ledum groenlandicum Coix Lacryma-Jobi 33.7 Lens culinaris subsp culinaris Coriandrum Sativum 59.2 Lens culinaris subsp culinaris 1. Coriandrum Sativum 37.1 Levisticum officinale Cornus Canadensis 82.6 Levisticum officinale Conus Canadensis 47.7 Lotus corniculatus Crataegus sp 33.9 Lotus corniculatus Crataegu.S. Subnois 64.3 Lupinus polyphyllius Cryptotaenia Canadensis 60.9 Lupinus polyphyllius 4 Cryptotaenia Canadensis 41.5 Luzula Sylvatica 6 2. 6 Cymbopogon citratus 65.2 Ribes Sylvestre 8 7 9 Cymbopogon citratus 65.6 Ribes SiyiveStre 40.2 Daucus carota 27.5 Ribes SiyiveStre 45.2 DioScorea batatas 423 RoSmarinus officinalis 69.6 Dirca palustris 57.4 Rubus canadensis 37.2 Dirca palustris 29.5 Rubus canadensis 57.9 Echinacea purpurea 83.O Rubus idaeus 64.9 Eleusine Coracana 70.3 Rubus idaeus 94.9 Erysimum perofskianum 90.4 RuneS Scutatus 74.9 Erysimum perofskianum 92.2 RuneS Scutatus 20.7 Fagopyrun eSculentum 61.6 Runnex acetoSella 40.1 Fagopyrun eSculentum 39.0 Runnex acetoSella 42.O Fagopyrun tataricum 36.7 Rumex crispus 40.7 Malus 70.9 Rumex crispus 51.2 Maius hupehensis 77.6 Ruta graveolens 91.2 Maius hupehensis 72.4 Salix purpurea 55.5 US 2004/0175439 A1 Sep. 9, 2004 62

TABLE 8-continued TABLE 8-continued

Cath L Cath L Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Salix purpurea T O 51.2 Triticium aestivium T R 31.4 Salvia Officinalis T R 64.7 Triticium aestivium T O 33.8 Salvia Officinalis T O 66.6 Tropaeoium nails T R 29.2 Sambucus Canadensis T O 92.5 Tropaeoium nails T O 20.9 Sambucus Canadensis T R 64.O Typha latifolia T R 67.O Sanguisorba minor T O 68.4 Typha latifolia T O 56.O Santolina Chamaecyparissus T R 84.4 Senecio vulgaris T R 34.O Santolina Chamaecyparissus T O 33.9 Setaria italica T R 40.7 Saponaria Oficinalis T R 59.3 Silene vulgaris T R 66.3 Saponaria Oficinalis T O 80.4 Silene vulgaris T O 99.7 Satureia hortensis T O 26.5 Sium Sisarun T O 90.7 Satureia hortensis T R 23.O Sium Sisarun T R 39.6 Satureia montana T R 57.2 Solidago sp T R 44.3 Satureia montana T O 43.5 Solidago sp T O 73.6 Satureia repandra T R 47.1 Sonchus oleraceus T R 53.7 Satureia repandra T O 66.3 Sonchus oleraceus T O 36.9 Scuttellaria lateriflora T O 20.3 Sorghum caffronun T R 96.4 Scuttellaria lateriflora T R 33.8 Sorghum caffronun T O 80.1 Secale cereale T R 28.5 Sorghum dochna T R 95.3 Phaiaris canariensis T R 33.6 Sorghum dochna T O 70.3 Phaiaris canariensis T O 86.5 Sorghum dochna T R 98.5 Phaseolus vulgaris T O 57.O Sorghum dochna T O 85.3 Physalis pruinosa T O 58.2 Sorghum durra T R 86.5 Pimpinella anisum T O 95.9 Sorghum durra T O 81.7 Pimpinella anisum T R 91.7 Sorghun Sudanense T R 34.7 Pisun Sativium T R 30.5 Stachys affinis T O 75.7 Pisun Sativium T O 69.3 Stachys affinis T R 33.5 Plantago major T O 93.8 Stachys byzantina T R 60.8 Plantago major T R 2O2 Stachys byzantina T O 77.5 Plectranthus sp. T R 44.4 Stellaria graminea T R 37.5 Plectranthus sp. T O SO.8 Stellaria graminea T O 54.7 Polygonum aviculare T R 47.9 Stellaria media T R 26.0 Polygonum aviculare T O 72.7 Stellaria media T O 49.0 Potentilla anSerina T R 21.8 Stipa capiliata T R 43.4 Prunella vulgaris T R 84.3 Urtica dioica T R 77.8 Prunella vulgaris T O 56.7 Urtica dioica T O 75.6 Pteridium aquilinum T R 32.6 Vaccinium angustifolium T O 58.6 Raphanus raphanistrum T R 68.6 Vaccinium macrocarpon T R 20.1 Raphanus raphanistrum T O 77.0 Vaccinium macrocarpon T O 41.7 Raphanus Sativus T R 41.O Veratrun viride T O 57.1 Raphanus Sativus T O 63.1 Veratrun viride T R 26.6 Frangula ainus T O 27.0 Verbascum thapsus T O 72.8 Frangula ainus T R 45.3 Verbascum thapsus T R 56.O Ricinius communis T R 22.4 Viburnum trilobum T R 49.5 Ricinius communis T O 72.O Viburnum trilobum T O 56.8 Ribes nigrum T R 50.5 Vicia Satiya T O 73.9 Ribes nigrum T O 70.1 Vicia villosa T R 79.2 Symphytum officinale T R 55.1 Vicia villosa T O 70.9 Symphytum officinale T O 64.O Vinca minor T O 21.5 Tanacetum cinerariifolium T O 65.5 Vitis sp. T R 79.7 Tanacetum parthenium T R 45.2 Vitis sp. T O 97.4 fictionanacetum pathiumvulgare T . 5. Zea mayS T R 83.5 Tanacetum vulgare T O 86.O Zea mayS T O 58.2 Taraxacum officinale T O 1OO.O Taraxacum officinale T R 91.3 Teucrium chamaedrys T O 60.8 Teucrium chamaedrys L T R 69.2 0153 Thymus fragantissinus T R 97.8 Thymus fragantissinus T O 81.7 TABLE 9 Thymus praecox subsp arcticus T R 36.1 Thymus praecox subsp arcticus T O 31.8 Cath K Thymus pseudoianuginosus T R 33.9 Thymus pseudoianuginosus T O 43.7 Nora latin Stress Extrait Inhibition Thymus serpyllum T R 39.2 Thymus serpyllum T O 68.6 Achillea millefolium A. O 27.6 Thymus X citriodorus T O 70.9 Aconitum napeius A. O 74.O Thymus X citriodorus T R 46.1 Acorus Caianus A. O 74.8 Tiarella cordifolia T O 72.O Actinidia arguta A. R 28.1 Tragopogon porrifolius T O 40.O Actinidia arguta A. O 96.6 Tragopogon porrifolius T R 20.5 Agropyron repenS A. O 98.0 Triticosecala spp. T O 38.2 Alchemilia mollis A. O 61.3 US 2004/0175439 A1 Sep. 9, 2004 63

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nora latin Stress Extrait Inhibition Nora latin Stress Extrait Inhibition Alchemilia mollis 95.8 Fagopyrun tataricum 33.O Allium cepa 80.6 Foeniculum vulgare 40.3 Allium porrum 30.9 Fragaria x ananassa 44.8 Allium porrum 87.5 Fragaria x ananassa 92.3 Allium Sativum 71.2 GainSoga ciliata 55.3 Allium SchoenopraSun 78.2 Galium odoratum 88.4 Allium TuberoSun 99.6 Gaultheria hispidula 61.6 Aloe vera 6O.O Gaultheria hispidula 87.1 Aloe vera 78.4 Giechona hederacea 96.2 Althaea officinalis 98.1 Glycine max 41.6 Amaranthus retroflexus 37.4 Glycine max 1OO.O Amaranthus retroflexus 43.4 Glycyrrhiza glabra SO.8 Anethum graveolens 33.7 Glycyrrhiza glabra 90.2 Angelica archangelica 36.O Guizotia abyssinica 23.1 Angelica archangelica 85.2 Guizotia abyssinica 94.8 Apium graveolens 46.7 Hamamelis virginiana 91.8 Apium graveolens 88.8 Hedeoma pullegioides 93.3 Aralia nudicaulis 79.O Helleborus niger 82.9 Aralia nudicaulis 98.5 Hordeum hexastichon 26.9 Arctium minus 24.6 HySSopus officinalis 40.2 Arctium minus 67.9 Inula helenium 86.0 ArctostaphyloS uva-ursi 75.1 Ipomoea Batatas 25.6 ArctostaphyloS uva-ursi 89.8 Lathyrus Sativus 26.9 Arnoracia rusticana 92.3 Lathyrus Sativus 84.9 Aronia melanocarpa 60.1 Lathyrus Sylvestris 22.4 Aronia melanocarpa 61.6 Lathyrus Sylvestris 93.4 Aronia melanocarpa 82.3 Laurus nobilis 64.2 Artemisia Absinthium 88.6 Laurus nobilis 64.6 Artemisia dracunculus 55.6 Leonurus cardiaca 9O.O Aster sp 50.7 Levisticum officinale 49.4 Atropa belladonna 89.4 Levisticum officinale 53.3 Beckmannia eruciformis 86.O Lotus corniculatus 67.4 Beckmannia eruciformis 96.2 Lotus corniculatus 98.8 Beta vulgaris 69.3 Lycopersicon eSculentum 3O. Beta vulgaris 87.6 Malva Sylvestris 82.3 Beta vulgaris spp. Maritima 53.7 Medicago Sativa 44.0 Beta vulgaris spp. Maritima 84.2 Medicago Sativa 94.4 Borago officinalis 38.6 Melilotus albus 80.7 Brassica napus 43.5 Chenopodium quinoa 84.3 Brassica napus 84.4 Cicer arietinium 91. Brassica oleracea 60.6 Cichorium intybus 21.0 Brassica rapa 62.1 Cichorium intybus 94.8 Brassica rapa 98.9 Mentha piperita 60.8 Campanula rapunculus 77.0 Mentha pullegium 55.4 Canna edulis 32.O Mentha Spicata 97.0 CapSella bursa-pastoris 71.4 Mentha Suaveolens 46.8 CapSella bursa-pastoris 72.8 Nepeta cataria 32.6 Capsicum annuum 39.0 Nepeta cataria 67.2 Chaerophyllum bulbosum 86.6 Nicotiana tabacunn 34. Chelidonium maius 90.3 Oenothera biennis 48.5 Chenopodium bonus-henricus 38.8 Oenothera biennis 83.4 Chenopodium quinoa 423 Origanum majorana 63.2 Coix Lacryma-Jobi 35.2 Origanum vulgare 62.2 Coriandrum Sativum 63.6 Origanum vulgare 9O.O Coriandrum Sativum 84.4 Panax quinquefolius 32.3 Cornus Canadensis 58.6 Panax quinquefolius 75.9 Conus Canadensis 99.4 Panicum miliaceum 25.6 Crataegus sp 22.7 Panicum miliaceum 45.1 Crataegu.S. Subnois 45.4 Pastinaca Satiya 1OO.O Cryptotaenia Canadensis 26.3 Petasites japonicus 82.7 Cryptotaenia Canadensis 29.1 Petroselinum crispum 50.2 Cymbopogon citratus 45.2 Petroselinum crispum 85.7 Cyperus esculentius 75.O Petroselinum crispum 92.2 Daucus carota 92.9 Phaiaris canariensis 89.5 Dirca palustris 84.7 Phaseolus vulgaris 22.1 Dirca palustris 94.2 Phaseolus Vulgaris 90.3 Dryopteris filix-mas 85.7 Pimpinella anisum 72.4 Echinacea purpurea 89.8 Plantago major 22.2 Eleusine Coracana 50.6 Plantago major 99.8 Eleusine Coracana 58.7 Plectranthus sp. 73.5 Fagopyrun eSculentum 68.0 Potentilla anSerina 92.9 Fagopyrun tataricum 2O3 Pteridium aquilinum 81.9 US 2004/0175439 A1 Sep. 9, 2004 64

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nora latin Stress Extrait Inhibition Nora latin Stress Extrait Inhibition Raphanus raphanistrum A. O 70.2 Vicia villosa A. O 97.6 Raphanus Sativus A. R 28.4 Vinca minor A. O 74.6 Raphanus Sativus A. O 99.0 Vitis sp. A. R 82. Rheum rhabarbarium A. R 21.4 Vitis sp. A. O 99.5 Rheum rhabarbarium A. O 95.6 Zea mayS A. R 24.4 Ribes nigrum A. R 59.3 Zea mayS A. O 99.2 Ribes nigrum A. O 81.8 Achillea millefolium G O 42.8 Ribes Sylvestre A. O 98.6 Aconitum napeius G O 37. Ricinius communis A. R 78.5 Acorus Caianus G O 89.0 Ricinius communis A. O 90.2 Actinidia arguta G R 35.5 Rosa rugosa A. R 36.1 Actinidia arguta G O 45.4 Rubus allegheniensis A. O 59.3 Adiantum pedatun G O 25.0 Rubus Canadensis A. O 94.4 Salvia Officinalis A. O 67.8 Rubus idaeus A. R 58.4 Salvia Officinalis A. R 85.4 Rubus idaeus A. O 97.4 Saivia Sciarea A. O 61.O Runnex Acetosa A. O 83.9 Santolina Chamaecyparissus A. R 54. Runnex acetoSella A. R 46.7 Santolina Chamaecyparissus A. O 63. Runnex acetoSella A. O 90.9 Satureia montana A. O 75.6 Rumex crispus A. R 32.9 Scorzonera hispanica A. O 62.7 Rumex crispus A. O 91.8 Scutellaria laterifiora A. O 82.7 Runnex Sciutatus A. O 94.9 Allium SchoenoporaSun G O 88.7 Ruta graveolens A. O 92.5 Allium tuberoSun G O 8O.3 Salix purpurea A. O 44.8 Aloe vera G R 28.8 Salix purpurea A. R 68.1 althaea officinalis G O 94.5 Saivia elegans A. O 64.2 Amaranthus retroflexus G R 35.3 Melilotus albus A. O 98.9 Amaranthus retroflexus G O 73.8 Melissa officinalis A. O 89.4 Anethum graveolens G O 52.O Melissa officinalis A. R 93.6 Angelica archangelica G R 39.0 Mentha piperita A. O 60.1 Angelica archangelica G O 80.6 Senecio vulgaris L A. R 80.9 Apium graveolens G R 37.7 Setaria italica A. R 3O.O Apium graveolens G O 83.9 Setaria italica A. O 66.2 Aralia nudicaulis G O 86.7 Sium Sisarium A. R 3O.O Aralia nudicaulis G R 89.5 Sium Sisarium A. O 93.3 Arctium minius G R 27.1 Soianum tuberosum A. R 30.1 Arctium minius G O 93.4 Soianum tuberosum A. O 79.8 ArctostaphyloS uva-ursi G R 73.3 Solidago sp A. R 43.7 Arnoracia rusticana G O 53.8 Solidago sp A. O 72.1 Aronia melanocarpa G R 73.2 Sonchus oleraceus A. R 21.6 Aronia melanocarpa G O 81.2 Sonchus oleraceus A. O 92.4 Artemisia absinthium G R 92.0 Sorghum dochna A. O 60.9 Artemisia dracunculus G R 36.O Sorghum durra A. O 89.3 Artemisia dracunculus G O 72.7 Stachys affinis A. R 29.3 Asclepias incarnata G R 67.4 Stachys byzantina A. R 28.3 Asclepias incarnata G O 87.O Stellaria graminea A. R 49.9 Asparagus Officinalis G O 98.2 Stellaria graminea A. O 87.6 Aster G O 37.4 Stellaria media A. R 25.7 Aster sp G R 37.3 Stellaria media A. O 26.0 Aster sp G O 813 Tanacetum parthenium A. R 64.6 Beckmannia eruciformis G O 90.0 Tanacetum vulgare A. R 36.0 Beta vulgaris G O 29.0 Tanacetum vulgare A. O 85.7 Beta vulgaris G R 71.5 Taraxacum officinale A. R 36.9 Borago officinalis G O 36.4 Taraxacum officinale A. O 1OO.O Brassica napus G R 26.6 Teucrium chamaedrys A. O 92.5 Brassica napus G O 98.8 Thymus praecox subsp arcticus A. O SO.1 Brassica oleracea G O 97.8 Thymus serpyllum A. R 27.3 Brassica rapa G R 25.3 Thymus serpyllum A. O 88.9 Brassica rapa G O 67.8 Thymus vulgaris A. R 60.9 Caianagrostis arundiflora G R 23.2 Thymus vulgaris A. O 74.3 Campanula rapunculus G O 80.2 Thymus x citriodorus A. O 80.9 Canna edulis G R 31.6 Tragopogon porrifolius A. R 43.2 Canna edulis G O 44.2 Tragopogon porrifolius A. O 81.9 CapSella bursa-pastoris G R 63.0 Tropaedium nails A. R 42.6 CapSella bursa-pastoris G O 69.5 Tropaedium nails A. O 82.6 Carium carvi G O 32.3 Typha latifolia A. O 49.5 Chaerophyllum bulbosum G R 3O.7 Typha latifolia A. R 65.4 Chaerophyllum bulbosum G O 38.0 Vaccinium Corymbosum A. O 94.5 Chelidonium maius G O 91.3 Vaccinium macrocarpon A. O 94.1 Cicer arietinium G R 44.7 Veratrun viride A. O 78.4 Cicer arietinium G O 92.7 Verbascum thapsus A. O 96.4 Cichorium endivia subsp. Endivia G O 94.9 Vicia Satiya A. O 98.7 Cichorium intybus G R 25.8 Vicia villosa A. R 29.0 Agropyron repenS G O 98.2 US 2004/0175439 A1 Sep. 9, 2004 65

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nora latin Stress Extrait Inhibition Nora latin Stress Extrait Inhibition Alchemilia mollis 65.5 Melissa officinalis 33.2 Alchemilia mollis 88.9 Melissa officinalis 90.6 Allium anpeiopraSun 39.0 Mentha piperita 4.1.8 Allium anpeiopraSun 53.8 Mentha pullegium 38.7 Allium cepa 35.6 Mentha Spicata 32.7 Allium cepa 75.1 Mentha Spicata 80.1 Allium Sativum 82.4 Mentha Suaveolens 55.7 Daucus carota 57.3 Nepeta cataria 93.1 Dirca palustris 67.1 Ocinum basilicum 75.6 Dirca palustris 97.2 Oenothera biennis 42.9 Dryopteris filix-mas 52.2 Oenothera biennis 86.1 Echinacea purpurea 74.4 Origanum majorana 65.8 Eleusine Coracana 38.7 Origanum vulgare 89.6 Eleusine Coracana 76.8 Origanum vulgare 92.3 Erigeron Speciosus 26.8 Oryza Sativa 95.6 Erysimum perofskianum 59.8 Oxalis Deppei 86.3 Erysimum perofskianum 100.2 Oxalis Deppei 87.8 Fagopyrun eSculentum 37.6 Oxyria digyna 20.8 Fagopyrun tartaricum 27.3 Oxyria digyna 89.3 Fagopyrun tartaricum 30.7 Panax quinquefolius 52.7 GainSoga ciliata 30.9 Panicum miliaceum 31.5 GainSoga ciliata 51.3 Panicum miliaceum 94.4 Galium odoratum 96.9 Passiflora caerulae 21.1 Gaultheria hispidula 70.9 Passiflora caerulae 60.6 Gaultheria hispidula 82.2 Pastinaca Satiya 72.8 Gaultheria procumbens 69.6 Pennisetum alopecuroides 30.6 Giechona hederacea 94.O Petasites japonicus 81.6 Glycine max 76.1 Petroselinum crispum 62.9 Glycine max 1OO.O Petroselinum crispum 76.3 Glycyrrhiza glabra 33.3 Phaiaris canariensis 22.O Glycyrrhiza glabra 94.5 Phaiaris canariensis 36.7 Guizotia abyssinica 41.5 Phaseolus vulgaris 65.5 Guizotia abyssinica 95.4 Phaseolus vulgaris 88.2 Hamamelis virginiana 79.7 Pimpinella anisum 46.2 Hamamelis virginiana 90.8 Pisun Stativum 52.5 Helianthus Strunosus 31.7 Plantago major 29.0 Helianthus Strunosus 39.4 Plantago major 96.3 Helianthus tuberosus 31.5 Plectranthus sp. 54.5 Helianthus tuberosus 7O6 Polygonum aviculare 29.6 Helichrysum thianschanicum 40.4 Portulaca oleracera 50.9 Helichrysum thianschanicum 69.2 Potentilla anSerina 92.5 Helleborus niger 43.8 Poterium Sanquisorba 74.2 Helleborus niger 90.6 Prunella vulgaris 77.1. Hordeum hexaStichon 22.6 Prunella vulgaris 91.8 Hordeum hexaStichon 86.0 Pteridium aquilinum 87.5 HySSopus officinalis 25.8 Levisticum officinale 75.1 Inula helenium 82.2 Levisticum officinale 92.5 Lactuca Sativa 28.5 Lotus corniculatus 25.7 Lactuca Sativa 95.5 Lotus corniculatus 98.5 Lathyrus Sylvestris 22.1 Lupinus polyphyllius 94.5 Lathyrus Sylvestris 79.5 Lupinus polyphyllius 99.9 Laurus nobilis 49.6 Lycopersicon eSculentum 7O.O Laurus nobilis 72.3 Lycopersicon eSculentum 90.2 Lavandula angustifolia 57.6 Maius hupehensis 44.8 Lavandula angustifolia 65.2 Maius hupehensis 82.9 Ledum groenlandicum 35.1 Medicago Sativa 26.2 Ledum groenlandicum 97.9 Medicago Sativa 99.2 Leonurus cardiaca 99.9 Ruta graveolens 46.4 Cichorium intybus 95.8 Ruta graveolens 846 Circium arvense 73.O Salix purpurea 32.4 Circium arvense 96.5 Salix purpurea 95.3 Coix Lacryma-Jobi 57.4 Saivia elegans 57.O Cornus Canadensis 62.5 Salvia Officinalis 65.8 Cornus Canadensis 68.0 Salvia Officinalis 94.9 Crataegu.S. Subnois 58.3 Saivia Sciarea 58.5 Crataegu.S. Subnois 73.2 Sambucus ebulus 32.1 Cymbopogon citratus 65.5 Sambucus ebulus 67.7 Cymbopogon citratus 70.9 Santolina Chamaecyparissus 49.3 Cyperus esculentius 85.O Saponaria Officinalis 22.3 Daucus carota 23.3 Saponaria Officinalis 88.5 Melilotus alba 96.9 Satureia hortensis 73.3 Melilotus alba 99.0 Satureia montana 74.8 US 2004/0175439 A1 Sep. 9, 2004 66

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nora latin Stress Extrait Inhibition Nora latin Stress Extrait Inhibition Scorzonera hispanica G R 43.1 Acorus Caianus T O 94.2 Scorzonera hispanica G O 52.1 Actinidia arguta T R 52.4 Scutellaria lateriflora G O 92.0 Actinidia arguta T O 84.8 Secale cereale G R 23.7 Adiantum pedatun T O 92.2 Senecio vulgaris G R 29.1 Agrinonia eupatoria T O 39.2 Setaria italica G R 21.9 Agropyron rupens T O 97.3 Setaria italica G O 83.2 Alchemilia mollis T O 85.2 Silene vulgaris G R 24.1 Alchemilia mollis T R 96.8 Stun Sisarun G R 37.9 Allium anpeiopraSun T R 33.5 Sium Sisarun G O 1OO.O Allium anpeiopraSun T O 94.1 Soianum melongena G R 22.7 Allium cepa T R 54.4 Soianum tuberosum G R 50.2 Allium cepa T O 1OO.O Soianum tuberosum G O 73.3 Allium Sativum T O 76.5 Solidago sp G R 32.8 Allium Schoenopra Sun T O 87.O Solidago sp G O 87.3 Allium tuberoSun T R 53.6 Sonchus oleraceus G R 37.8 Allium tuberoSun T O 98.7 Sonchus oleraceus G O 48.1 Aloe vera T R 43.7 Sorghum dochna G R 43.1 Aloe vera T O 79.9 Sorghum dochna G O 91.3 Althaea officinalis T O 95.8 Sorghun durira G R 56.4 Tanacetum parthenium G R 67.9 Sorghun durira G O 63.2 Tanacetum vulgare G R 49.5 Sorghum Sudanense G R 56.1 Tanacetum vulgare G O 97.8 Sorghum Sudanense G O 89.7 Taraxacum officinale G R 45.4 Stachys Affinis G R 27.9 taraxacum Oficinale G O 1OO.O Stachys byzantina G R 42.8 Teucrium chamaedrys G R 61.7 Stachys byzantina G O 72.1 Teucrium chamaedrys G O 89.8 Stellaria graminea G R 39.7 Thymus fragantissinus G O 64.O Stellaria media G R 27.9 Thymus fragantissinus G R 85.4 Stellaria media G O SO.O Thymus praecox subsp arcticus G R 28.3 Symphytum officinale G O 43.5 Thymus praecox subsp arcticus G O 39.1 Symphytum officinale G R 74.2 Thymus Serpyllum G R 28.4 Tanacetum cinerariifolium G O 72.2 Thymus Serpyllum G O 90.3 Rhaphanus Sativus G R 24.0 Thymus vulgaris G R 69.0 Rhaphanus Sativus G O 85.O Thymus vulgaris G O 7O6 Rheum rhabarbarium G R 22.9 Thymus x citriodorus G O 70.7 Rheum rhabarbarium G O 85.5 Asclepias incarnata T R 86.7 Ribes nidigrolaria G O 59.7 Aster T O 34.1 Ribes nigrum G O 80.4 Aster sp T R 46.8 Ribes nigrum G R 81.5 Aster sp T O 49.7 Ribes Sylvestre G O 91.7 Atropa belladonna T O 71.7 Ricinius communis G R 27.0 Avena Sativa T R 40.4 Ricinius communis G O 98.3 Beta vulgaris T O 30.6 RoSmarinus officinalis G O 27.5 Beta vulgaris T R 41.7 Rubus idaeus G R 38.7 Borago officinalis T R 59.2 Rubus idaeus G O 51.2 Borago officinalis T O 76.5 Rumex crispus G R 37.1 Brassica napus T R 35.8 Rumex crispus G O 95.0 Brassica Napus T O 91.9 Rumex Sciutatus G O 88.5 Brassica nigra T R 24.3 Tiarella cordifolia G O 88.4 Brassica oleracea T O 83.8 Tropaeiun nails G O 76.8 Bronius inermis T O 69.6 Typha latifolia G O 76.4 Bronius inermis T R 91.2 Typha latifolia G R 82.9 Calendula officinalis T R 34.5 Vaccinium corymbosum G R 72.1 Canna edulis T R 20.5 Vaccinium corymbosum G O 95.4 Canna edulis T O 73.5 Vaccinium macrocarpon G O 95.3 CapSella bursa-pastoris T R 32.1 Veratrun viride G O 80.8 CapSella bursa-pastoris T O 75.1 Verbascum thapsus G R 27.3 Carex morrowii T R 44.0 Verbascum thapsus G O 91.3 Carex morrowii T O 94.3 Viburnum trilobum G O 68.5 Carium carvi T R 20.5 Viburnum trilobum G R 72.6 Cerastium tonentOSun T R 36.8 Vicia Satiya G R 32.2 Chaerophyllum bulbosum T R 23.O Vicia Satiya G O 96.8 Chaerophyllum bulbosum T O 80.2 Vicia villosa G R 29.7 Chelidonium maius T O 94.3 Vicia villosa G O 98.7 Chenopodium quinoa T O 48.2 Vinca minor G O 35.8 Chenopodium quinoa T R 48.3 Vitis sp. G R 77.5 Cicer arietinium T R 25.6 Vitis sp. G O 99.8 Cicer arietinium T O 81.7 Zea mayS G O 54.2 Cichorium endivia subspendivia T R 20.8 Zea mayS G R 56.O Cichorium endivia subspendivia T O 95.5 Perilla frutescens T R 83.5 Cichorium intybus T R 20.4 Achillea millefolium T O 89.0 Cichorium intybus T O 96.O Aconitun napeius T O 63.6 Circium arvense T R 58.3 US 2004/0175439 A1 Sep. 9, 2004 67

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nora latin Stress Extrait Inhibition Nora latin Stress Extrait Inhibition Circium arvense T O 79.6 Cyperus esculentius T O 72.O Citrulius colocynthis T R 41.2 Dirca palustris T R 67.1 Citrulius colocynthis T O 84.9 Dirca palustris T O 82.2 Coriandrum Sativum T O 38.4 Dryopteris filix-mas T O 23.9 Coriandrum Sativum T R 48.8 Echinacea purpurea T O 92.2 Cornus Canadensis T O 32.1 Eleusine Coracana T R 3O.O Anaranthus caudathus T R 20.7 Erysimum perofskianum T R 81.7 Anaranthus caudathus T O 69.3 Erysimum perofskianum T O 98.8 Amaranthus retroflexus T R 32.4 Fagopyrun esculentum T O 35.5 angelica archangelica T R 44.2 Fagopyrun tararicum T O 40.O angelica archangelica T O 55.7 Fagopyrun tataricum T R 30.1 Anthriscus cerefolium T O 96.1 Foeniculum vulgare T O 21.0 Apium graveolens T R 30.3 Fpomoea batataS T O 98.6 Aralia nudicaulis T R 68.2 Menyanthes trifoliata T O 64.3 Aralia nudicaulis T O 97.8 Miscanthus Sinensis Andress T R 36.1 Arctium minus T O 92.9 Miscanthus Sinensis Andress T O 66.6 ArctostaphyloS uva-ursi T O 72.O Nepeta cataria T O 23.6 ArctostaphyloS uva-ursi T R 79.8 Ocinum Basilicum T O 813 Arnoracia rusticana T O 88.0 Oenothera biennis T R 35.7 Aronia melanocarpa T R 74.9 Oenothera biennis T O 75.6 Aronia melanocarpa T O 8O.O Onobrychis viciifolia T R 44.5 Artemisia absinthium T O 41.7 Onobrychis viciifolia T O 90.7 Artemisia absinthium T R 96.1 Origanum vulgare T R 76.5 Artemisia dracunculus T O 96.2 Origanum vulgare T O 82.9 Artium lappa T O 21.1 Oryza Sativa T O 51.4 Asclepias incarnata T O 81.5 Oxalis Deppei T R 48.4 Fragaria x ananassa T O 44.3 Oxalis Deppei T O 73.4 GainSoga ciliata T R 49.4 Oxyria digyna T R 23.6 Galinsoga ciliata T O 56.9 Oxyria digyna T O 92.5 Galium odoratum T R 59.4 Panax quinquefolius T O 24.8 Galium odoratum T O 95.3 Panax quinquefolius T R 36.6 Gaultheria hispidula T R 37.9 Panicum miliaceum T R 26.9 Gaultheria hispidula T O 78.5 Passiflora caerulea T R 55.3 Gaultheria procumbens T O 85.7 Passiflora caerulea T O 77.6 Giechona hederacea T O 95.9 Pastinaca Satiya T O 49.2 Glycine max T O 96.8 Pastinaca Satiya T O 82.9 Glycine max T R 32.8 Pennisetum alopecuroides T O 74.9 Glycine max T O 1OO.O Petasites Japonicus T R 22.9 Glycyrrhiza glabra T R 70.2 Petasites Japonicus T O 79.5 Glycyrrhiza glabra T O 90.3 Petroselinum crispum T O 61.1 Guizotia abyssinica T R 34.4 Petroselinum crispum T O 83.7 Guizotia abyssinica T O 97.9 Petroselinum crispum T R 99.0 Hamamelis virginiana T R 72.1 Phaiaris canariensis T R 29.5 Hamamelis virginiana T O 77.1. Phaiaris canariensis T O 67.2 Hedeoma pullegioides T O 34.7 Phaseolus vulgaris T O 93.1 Helianthus Strunosus T R 20.6 Physalis pruinosa T O 64.2 Helianthus Strunosus T O 57.2 Pimpinella anisum T R 59.0 Helianthus tuberosa T O 61.O Pimpinella anisum T O 88.5 Helianthus tuberosus T R 46.9 Pisun Stativum T O 75.4 Helichrysum angustifolium T O 23.5 Plantago major T O 99.6 Helichrysum angustifolium T R 94.5 Plectranthus sp. T R 49.4 Helichrysum thianschanicum T R 98.1 Podophyllum peltatum T O 87.3 Helleborus niger T O 26.2 Laurus nobilis T R 51.7 Huniulus lupulus T R 38.0 Lauras nobilis T O 87.2 Huniulus lupulus T O 93.8 Lavandula latifolia T R 75.5 Hyoscyanus niger T O 41.5 Lavendula angustifolia T R 81.9 HySSopus officinalis T R 44.6 Ledum groenlandicum T R 45.9 Inula helenium T O 97.6 Ledum groenlandicum T O 99.5 Juniperus Communis T R 8O.O Lens culinaris subsp. Culinaris T R 28.0 Koeleria glauca T O 94.7 Lens culinaris subsp. Culinaris T O 97.6 Koeleria glauca T R 99.4 Levisticum officinale T R 51.4 Lactuca Sativa T O 94.O Levisticum officinale T O 87.8 Lathyrus Sativus T R 24.0 Lotus corniculatus T R 53.7 Lathyrus Sativus T O 33.O Lotus corniculatus T O 97.4 Lathyrus Sylvestris T O 43.1 Lupinus polyphyllius T O 95.8 Cornus Canadensis T R 80.2 Lupinus polyphyllius T R 99.3 Crataegus sp T R 22.9 Luzula Sylvatica T R 29.5 Crataegu.S. Subnois T O 81.5 Maius hupehensis T R 58.7 Cryptotaenia Canadensis T R 20.9 Maius hupehensis T O 62.5 Cymbopogon citratus T R 40.5 Malus spp. T O 25.7 Cymbopogon citratus T O 77.0 Malva Sylvestris T O 73.5 Cyperus esculentius T R 20.9 Medicago Sativa T R 46.2 US 2004/0175439 A1 Sep. 9, 2004 68

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nora latin Stress Extrait Inhibition Nora latin Stress Extrait Inhibition Medicago Sativa T O 94.9 Vaccinium macrocarpon T R 78.0 Melilotus officinalis T O 99.4 Vaccinium macrocarpon T O 87.8 Melissa officinalis T R 91.O Veratrun viride T O 90.2 Mentha piperita T O 86.8 Verbascum thapsus T O 84.3 Ruta graveolens T O 68.5 Viburnum trilobum T R 45.2 Salix purpurea T R 37.1 Viburnum trilobum T O 7O.O Salix purpurea T O 46.1 Vicia Satiya T O 99.0 Salvia Officinalis T O 67.7 Vicia villosa T R 44.2 Salvia Officinalis T R 91.1 Vicia villosa T O 98.3 Sambucus Canadensis T R 35.7 Vinca minor T O 21.5 Sambucus Canadensis T O 99.O Vitis sp. T O 99.9 Sanguisorba minor T O 90.6 Zea mayS T R 31.7 Santolina T O 62.7 Zea mayS T O 90.2 Santolina T R 73.4 Sorghum durra T O 76.5 Saponaria Oficinalis T O 93.2 Sorghun Sudanense T O 40.5 Satureia hortensis T R 43.1 Stachys affinis T R 67.2 Satureia hortensis T O 87.9 Stachys affinis T O 86.6 Satureia montana T R 55.1 Stachys byzantina T R 85.7 Satureia montana T O 79.2 Stellaria graminea T O 43.3 Satureia repandra T R 49.7 Stellaria graminea linné T R 39.2 Satureia repandra T O 73.3 Stellaria media T R 21.1 Scorzorera hipanica T O 6.3.3 Stipa capiliata T R 24.2 Scuttellaria lateriflora T O 29.3 Symphytum officinale T R 64.4 Setaria italica T R 20.8 Tanacetum parthenium T R 62.2 Silene vulgaris T O 96.8 Tanacetum vulgare T R 42.5 Sium Sisarun T R 27.4 Tanacetum vulgare T O 97.5 Sium Sisarun T O 88.8 Taraxacum officinale T R 47.5 Soianum melongens T R 21.9 Taraxacum officinale T O 1OO.O Solidago sp T R 45.9 Teucrium chamaedrys T R 40.O Solidago sp T O 74.O Thymus fragantissinus T O 93.7 Sonchus oleraceus T R 22.7 Thymus fragantissinus T R 97.3 Sonchus oleraceus T O 38.1 Thymus praecox subsp arcticus T O 46.0 Sorghum caffronun T O 57.O Thymus pseudoianuginosus T R 74.3 Sorghum caffronun T R 74.O Thymus Serpyllum T O 88.6 Sorghum dochna T O 44.3 Thymus X citriodorus T R 66.4 Sorghum dochna T O 65.8 Thymus X citriodorus T O 97.8 Sorghum dochna T R 70.7 Tiarella cordifolia T O 94.9 Sorghum dochna T R 89.0 Tragopogon porrifolius T R 45.O Sorghum durra T R 39.6 Tragopogon porrifolius T O 72.O

CCOlgesiili titleCiidae T Triticosecale spp T R 27.8 FET anSerina T O 94.9 Triticosecale spp T O 87.8 Prunella vulgaris T O 76.4 Prunella vulgaris T R 94.7 Pteridium aquilinum T O 90.1 Raphanus raphanistrum T R 39.5 0154) Raphanus raphanistrum T O 91.O Raphanus Sativus T O 79.1 TABLE 10 Ribes nigrum T R 89.6 Rites nigrum T O 95.4 HLE Ribes Sylvestre T R 20.1 Ribes Sylvestre T O 97.4 Nom latin Stress Extrait Inhibition (%) Ricinius communis T R 26.5 Ricinius communis T O 92.4 Achillea millefolium A. O 21.9 Rosa rugosa T O 41.6 Achillea millefolium A. S 24.5 Rubus Canadensis T O 96.4 Aconitum napeius A. O 25.8 Rubus idaeus T R 44.8 Adiantum pedatun A. R 27.6 Rubus idaeus T O 88.7 Agrinonia eupatoria A. V 26.0 RuneS Sciutatus T O 88.7 Agropyron cristatun A. R 21.0 Runnex acetoSella T R 40.9 Agropyron repenS A. S 23.4 Runnex acetoSella T O 90.9 Agropyron repenS A. R 28.2 Rumex crispus T R 33.4 Agropyron repenS A. S 39.8 Rumex crispus T O 89.3 Agrostis Stofonifera A. O 38.9 Triticium aestivium T R 26.6 Alchemilia mollis A. V 27.9 Triticium aestivium T O 42.6 Alchemilia mollis A. O 66.O Tropaedium nails T R 21.4 Alchemilia mollis A. R 1OO.O Tropaedium nails T O 81.5 Alchemilia mollis A. S 23.5 Typha latifolia T O 44.8 Alkanna tinctoria A. S 26.2 Typha latifolia T R 72.5 Allium TuberoSun A. S 57.9 Urtica dioica T R 35.2 Aloe vera A. O 20.5 Urtica dioica T O 62.9 Ambrosia artemisiifolia A. O 29.1 Vaccinium angustifolium T R 27.4 Anelanchier Sanguinea A. W 96.5 US 2004/0175439 A1 Sep. 9, 2004 69

TABLE 10-continued TABLE 10-continued

HLE HLE Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Anelanchier Sanguinea 52.4 Fragaria Xananassa 22.3 Anethum graveolens 32.1 Fragaria Xananassa 1OO.O Anethum graveolens 22.8 Fragaria Xananassa 21.4 Angelica archangelica 39.2 Fragaria Xananassa 29.4 Anthenis nobilis 37.6 Fragaria Xananassa 21.6 Anthenis nobilis 26.4 GainSoga ciliata 61.6 Anthenis tinctoria 31.9 Galium odoratum 21.0 Anthenis tinctoria 38.4 Gaultheria hispidula 33.7 Apium graveolens 49.2 Gentiana lutea 52.1 Arctium minus 46.4 Giechona hederacea 21.8 ArctostaphyloS uva-ursi 1OO.O Glycine Max 813 Aronia melanocarpa 21.9 Glycyrrhiza glabra 1OO.O Aronia melanocarpa 78.4 Glycyrrhiza glabra 6.3.3 Aronia melanocarpa 1OO.O Guizotia abyssinica 36.9 Aronia melanocarpa 29.0 Hamamelis virginiana 1OO.O Aronia melanocarpa 33.6 Helianthus Tuberosus 32. Artemisia dracunculus 89.2 Heliotropium arborescens 22.8 Ludoviciana 33.4 Heliotropium arborescens 24.9 Ludoviciana 20.7 Helleborus niger 25.6 Aster sp 26.2 Hordeum vulgare 58. Beta vulgaris 1OO.O Hypericum perforatum 24.8 Beta vulgaris spp. Maritima 92.2 HySSopus officinalis 21. Borago officinalis 22.6 HySSopus officinalis 93.6 Brassica napus 68.3 Lactuca Serrioia 34.3 Brassica napus 29.5 Laurus nobilis 1OO.O Brassica nigra 32.6 Lavandula latifolia 57. Brassica oleracea 22.9 Lavandula latifolia 43.7 Brassica oleracea 20.8 Chenopodium quinoa SO.4 Brassica oleracea 22.2 Chrysanthemum coronarium 26.0 Brassica rapa 23.2 Cicer arietinium 23.3 Brassica rapa 26.9 Cichorium intybus 32. Bronius inermis 34.1 Lolium multiflorum 31.0 Bronius inermis 21.9 Lolium perenne 20.8 Calamintha nepeta 35.4 Lolium perenne 21.7 Canna edulis 56.4 Lolium perenne 22. Canna edulis 21.4 Malva Sylvestris 22.9 Carium carvi 24.2 Matricaria recutita 28.5 Chaerophyllum bulbosum 25.5 Melaleuca alternifolia 21.9 Chenopodium bonus-henricus 24.O Melissa officinalis 23.4 Chenopodium bonus-henricus 85.8 Mentha piperita 31.6 Citrulius ianatus 26.3 Mentha piperita 33.2 Coix Lacryma-Jobi 86.1 Mentha pullegium 42.2 CoSnoS Sulphureus 33.8 Mentha pullegium 21.5 CoSnoS Sulphureus 20.7 Mentha pullegium 33.8 Crataegus sp 84.1 Mentha Spicata 24.3 Crataegus sp 23.6 Oenothera biennis 25.2 Crataegus sp 21.7 Oenothera biennis 78.8 Crataegu.S. Subnois 34.O Origanum majorana 37.4 Cryptotaenia Canadensis 22.1 Oxyria digyna 28.2 Cucunnis anguria 26.2 Panicum miliaceum 33.3 Cucunnis Anguria 53.4 Peucedanum cervaria 23.4 Cucunnis meio 53.6 Phaiaris arundinacea 22.4 Cucunnis Sativus 53.3 Phaiaris canariensis 27.6 Curcuna zedoaria 24.3 Phaseolus coccineus 28.3 Cymbopogon citratus 91.2 Phaseolus nungo 3 Datisca cannabina 55.7 Phaseolus vulgaris 4. Daucus carota 1OO.O Phaseolus Vulgaris Daucus carota 24.7 Phleum pratense Daucus carota 37.9 Physalisixocarpa Digitalis purpurea 34.O Physalisixocarpa Dirca palustris 20.3 Physalis Pruinosa Dirca palustris 27.9 Phytolacca americana 1. DolichoS Labiab 21.5 Plantago Coronopus Dryopteris filix-mas 58.8 Plantago Coronopus Dryopteris filix-mas 22.O Plantago major Echinacea purpurea 38.2 Plectranthus sp. Echinacea purpurea 28.1 Poa pratensis Eleusine Coracana 20.7 Polygonum aviculare 9 Erigeron Canadensis 29.6 Portulaca olewcae 4 Fagopyrun eSculentum 29.3 Poterium Sanguisorba 5 Fagopyrun tataricum 24.4 Poterium Sanguisorba 4 Foeniculum vulgare 25.1 Poterium Sanguisorba US 2004/0175439 A1 Sep. 9, 2004 70

TABLE 10-continued TABLE 10-continued

HLE HLE Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Pteridium aquilinum 54.4 Aconitum napeius 23.1 Raphanus Sativus 66.4 Rubus idaeus 27.9 Raphanus Sativus 81.8 Rubus idaeus 37.4 Rheum officinale 37.9 Runnex Acetosa 45.2 Ribes nigrum 1OO.O Rumex crispus 26.1 Ribes nigrum 47.6 Rumex crispus 1OO.O Ribes nigrum 27.5 Runnex Sciutatus 43.8 Ribes rubrun 35.4 Ruta graveolens 28.7 Ribes Sylvestre 1OO.O Saccharum officinarum 29.6 Rosa rugosa 95.1 Alchemilia mollis 20.6 Rosa rugosa 24.6 Alchemilia mollis 56.1 RoSmarinus officinalis 58.4 Alchemilia mollis 28.1 Rubus idaeus 27.6 Alchemilia mollis 25.3 Rubus idaeus 33.O Allium cepa 2O2 Lavandula latifolia 42.2 Allium Sativum 1OO.O Leonurus cardiaca 1OO.O Allium tuberoSun 1OO.O Lepidium Sativum 1OO.O Althaea officinalis 30.8 Saccharum officinarum 23.8 Anaranthus caudatus 22.3 Saivia elegans 1OO.O Anelanchier Sanguinea 88.3 Salvia Officinalis 95.7 Anethum graveolens 26.2 Salvia Officinalis 77.9 Angelica archangelica 43.2 Salvia Officinalis 83.7 Anthenis nobilis 21.7 Salvia Officinalis 20.5 ArctostaphyloS uva-ursi 33.1 Saivia Sciarea 1OO.O ArctostaphyloS uva-ursi 1OO.O Saivia Sciarea 28.6 ArctostaphyloS uva-ursi 23.4 Santolina Chamaecyparissus 27.1 Arnoracia rusticana 22.5 Satureia montana 23.2 Aronia melanocarpa 79.0 Satureia montana 27.7 Aronia melanocarpa 1OO.O Scorzonera hispanica 60.1 Aronia melanocarpa 22.7 Scutellaria lateriflora 45.9 Aronia melanocarpa 29.6 Senecio vulgaris 34.O Artemisia absinthium 31.5 Sonchus oleraceus 29.1 Artemisia absinthium 24.2 Sorghum dochna 21.1 Aster 29.2 Sorghum dochna 24.4 Beckmannia eruciformis 22.7 Sorghum durra 23.4 Beta vulgaris 1OO.O Sorghum durra 23.6 Betula glandulosa 26.7 Spinacia oleracea 26.8 Borago officinalis 25.7 Stellaria graminea 24.8 Brassica Napus SO.4 Symphytum officinale 91.6 Brassica napus 48.2 Tanacetum cinerariifolium 28.3 Brassica nigra 23.9 Tanacetum vulgare 46.3 Brassica oleracea 28.1 Tanacetum vulgare 33.7 Brassica oleracea 22.5 Taraxacum officinale 26.4 Brassica rapa 56.4 Taraxacum officinale 24.O Calamintha nepeta 2 4 8 Taraxacum officinale 21.0 Calamintha nepeta Teucrium chamaedrys 37.O Canna edulis Thymus fragantissinus 2O2 CapSella bursa-pastoris Thymus herba-barona 20.8 Carthamus tinctorius Thymus vulgaris 77.9 Chelidonium maius Thymus vulgaris 23.6 Chenopodium album Thymus x citriodorus 21.3 Cichorium endivia subsp. Endivia Thymus x citriodorus 21.1 Cicer arietinium Trichosanthes kirillowii 23.2 Cichorium endivia subsp. Endivia Trigonelia foenum graecum 32.O Cichorium endivia subsp. Endivia Triticum durum 22.O Coix Lacryma-Jobi Triticum turgidium 6O.O Cornus Canadensis Triticum spelta 47.6 Crataegus sp 5 7 Urtica dioica 33.3 Cucurbita Pepo Vaccinium augustifolium 42.6 Curcuna zedoaria Vaccinium Corymbosum 22.4 Datura metel Vaccinium Corymbosum 21.6 Aconitum napeius Vaccinium macrocarpon 22.5 Acorus Caianus Vaccinium macrocarpon 54.8 Adiantum pedatun 1OO.O Valerianella locusta 49.2 Agastache foeniculum 25.3 Veronica officinalis 43.7 Ageratum conyzoides 28.5 Viburnum trilobum Marsh. 75.4 Agropyron cristatun 37.3 Vitis 33.8 Agropyron repenS 31.4 Vitis 1OO.O Fagopyrun esculentum 32.9 Vitis 21.0 Fagopyrun tataricum 41.2 Zea Mays 95.2 Foeniculum vulgare 25.7 Achillea millefolium 28.8 Foeniculum vulgare 42.5 Achillea millefolium 27.3 Foeniculum Vulgare 24.1 US 2004/0175439 A1 Sep. 9, 2004 71

TABLE 10-continued TABLE 10-continued

HLE HLE Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) GainSoga ciliata 25.0 Petroselinum crispum 44.5 Galium odoratum 89.4 Petroselinum crispum 26.5 Gaultheria hispidula 35.1 Peucedanum cervaria 25.1 Gaultheria hispidula 67.2 Phaseolus coccineus 30.9 Gaultheria procumbens 74.7 Phaseolus coccineus 27.5 Glycine max 24.6 Phaseolus nungo 24.3 Glycyrrhiza glabra 56.8 Phlox paniculata 37.9 Glycyrrhiza glabra 3O.O Physalis pruinosa 26.5 Glycyrrhiza glabra 92.4 Phytolacca americana 1OO.O Glycyrrhiza glabra 28.6 Pimpinella anisum 23.7 Hamamelis virginiana 1OO.O Plantago Coronopus 25.1 Hamamelis virginiana 29.3 Plantago major 25.0 Hedeoma pullegioides 6O.O Plantago major 20.5 Helenium hoopesii 37.3 Plantago major 23.6 Helenium hoopesii 34.7 Poa compressa 28.5 Helianthus tuberosus 21.4 Poa pratensis 37.5 Helichrysum thianschanicum 43.O Polygonum aviculare 25.4 Helichrysum thianschanicum 39.2 Polygonum pensylvanicum 21.3 Heliotropium arborescens 22.8 Portulaca oleracea 28.0 Heliotropium arborescens 39.5 Poterium Sanguisorba 25.6 Helleborus niger 34.2 Poterium Sanguisorba 21.9 Hypericum henryi 23.7 Prunella vulgaris 23.4 Hypericum perforatum 23.8 Pteridium aquilinum 43.1 HySSopus officinalis 45.1 Reseda Odorata 46.5 HySSopus officinalis 24.2 Rhaphanus Sativus 32.6 Inula helenium 96.2 Rheum X cultorum 2O.9 Ipomoia batatas 21.9 Ribes nidigrolaria 29.8 Lactuca Sativa 35.1 Ribes nidigrolaria 53.7 Laportea canadensis 25.1 Ribes nigrum 20.3 Laportea Canadensis 26.5 Ribes SilveStre 91.6 Laserpitium latifolium 22.1 Ricinius communis 46.0 Lathyrus Sativus 29.9 RoSmarinus officinalis 60.4 Lathyrus Sativus 27.8 Rubus idaeus 28.2 Lathyrus Sativus 28.1 Rubus occidentalis 93.6 Laurus nobilis 1OO.O Mentha arvensis 65.5 Lavandula angustifolia 65.7 Mentha piperita 24.2 Ledum groenlandicum 1OO.O Mentha piperita 23.7 Leonorus cardiaca 61.3 Mentha piperita 34.2 Lepidium Sativum 1OO.O Mentha pullegium 6.3.3 Levisticum officinale 91.4 Mentha pullegium 30.2 Lolium perenne 37.3 Mentha Spicata 45.9 Lotus tetragonolobus 21.8 Monarda didyma 47.7 Lupinus polyphyllius 42.3 Nepeta cataria 1OO.O Maius hupehensis 25.9 Nicotiana tabacunn 75.8 Medicago Sativa 32.1 Hordeum vulgare subsp. Vulgare 33.4 Melaleuca alternifolia 40.O Sambucus ebulus 48.6 Melissa officinalis 23.1 Sanguisorba Officinalis 1OO.O Daucus carota 32.3 Santolina Chamaecyparissus 1OO.O Daucus carrota 90.9 Serratula tinctoria 56.8 Dipsacus Sativus 32.7 Satureia montana 34.1 Dirca palustris 33.5 Scolynus hispanicus 37.9 DolichoS Labiab 32.1 Scutellaria laterifiora 54.7 Dryopteris filix-mas 80.9 Senecio vulgaris 35.3 Echinacea purpurea 63.0 Solidago sp 22.6 Elymus Junceus 25.9 Sonchus oleraceus 23.7 Erigeron Canadensis 43.O Sorghum caffronun 27.1 Erigeron Speciosus 22.8 Sorghum dochna 40.7 Erigeron Speciosus 24.2 Sorghum dochna 21.4 Erysimum perofskianum 20.8 Sorghun Sudanense 23.3 Ocinum basilicum 40.1 Sorghun Sudanense 92.9 Ocinum basilicum 27.9 Stellaria graminea 25.4 Oenothera biennis 26.3 Stellaria media 30.4 Oenothera biennis 1OO.O Stellaria media 22.0 Oenothera biennis 49.6 Tanacetum vulgare 57.3 Oenothera biennis 54.O Tanacetum vulgare 38.4 Origanum vulgare 1OO.O Tanacetum vulgare 38.2 Origanum vulgare 26.7 Tanacetum vulgare 26.3 Origanum vulgare 21.3 Taraxacum officinale 2O.O Oryza Sativa 34.5 taraxacum Oficinale 28.0 Oxalis Deppei Lodd. 27.4 Thymus fragantissinus 79.9 Panicum miliaceum 25.3 Thymus fragantissinus 26.2 Pastinaca Satiya 95.0 Thymus herba-barona 2O2 US 2004/0175439 A1 Sep. 9, 2004 72

TABLE 10-continued TABLE 10-continued

HLE HLE Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Thymus serpyllum 22.2 Brassica hirta 30.2 Triticosecale spp. 29.7 Brassica iuncea 41.4 Triticum durum 37.8 Brassica Napus 29.9 Triticum spelta 31.O Brassica napus 22.9 Triticum spelta 37.9 Brassica oleracea 25.6 Typha latifolia 27.5 Brassica oleracea 27.0 Urtica dioica 60.3 Brassica oleracea 26.5 Vaccinium corymbosum 33.2 Brassica rapa 24.8 Vaccinium angustifolium 43.7 Vitis 3O.7 Vaccinium macrocarpon 57.8 Xanthium Sibiricum 22.1 Vaccinium macrocarpon 59.9 Zea mayS 20.3 Valerianella locusta 32.1 Abies lasiocarpa 22.4 Veratrun viride 22.1 Achillea millefolium 21.1 Verbascum thapsus 33.8 Aconitum napeius 1OO.O Viburnum trilobum 21.3 Acorus Caianus 21.0 Viburnum trilobum 73.O Ageratum conyzoides 20.1 Vicia faba 21.2 Agrinonia eupatoria 59.6 Vigna unguiculata 20.1 Agropyron cristatun 53.4 Vitis 26.O Agropyron repenS 22.6 Vitis 66.1 Agrostis aiba 25.3 Vitis 41.7 Alchemilia mollis 88.7 Rubus Occidentalis 40.O Alchemilia mollis 42.6 Runnex acetoSella 24.3 Alchemilia mollis 70.4 Rumex crispus 1OO.O Citrullus colocynthis 35.5 Rumex patientia 32.O Citrus innettoides 47.1 Rumex Sciutatus 28.6 Citrus innon 26.2 Ruta graveolens 23.4 Citrus innon 73.5 Saccharum officinarum 30.2 Citrus Sinensis 25.2 Salix purpurea 24.8 Coix Lacryma-Jobi 32.7 Saivia elegans 1OO.O Coix Lacryma-Jobi Salvia Officinalis 52.4 Conchorus oitorius Salvia Officinalis 1OO.O Conus Canadensis Salvia Officinalis 1OO.O Crataegus sp Saivia Sciarea 1OO.O Crataegu.S. Subnois Saivia Sciarea 23.O Curcuna longa Saivia Sciarea 31.1 Curcuna zedoaria 444 Sambucus ebulus 52.1 Cydonia oblonga Alchemilia mollis 31.2 Cynara Scolynus Allium ascaionicum 42.9 Cynara Scolynus Allium Sativum 1OO.O Dactilis Gionerata Allium tuberoSun 1OO.O Datura Stranonium Alpinia officinarum 21.9 Daucus Carota s Alpinia officinarum 1OO.O Daucus Carota Anaranthus candatus 36.O Dipsacus Sativus Anaranthus gangeticus 66.8 Dirca palustris Ananas COmoSuS 20.3 DolichoS labiab Ananas COmoSuS 23.8 Dryopteris filix-mas Anethum graveolens 35.8 Echinacea purpurea angelica archangelica 53.5 Eleusine Coracana Anthenis nobilis 45.3 Elymus iunceus Anthenis tinctorium 47.5 Erigeron Speciosus Anthriscus cerefolium 20.5 Erysimum perofskianum Arctium minus 54.1 Erysimum perofskianum ArctostaphyloS uva-ursi 28.1 Fagopyrun esculentum ArctostaphyloS uva-ursi 1OO.O Foeniculum vulgare Aronia melanocarpa 1OO.O Foeniculum vulgare Aronia melanocarpa 42.7 Foeniculum vulgare Aronia prunifolia 39.0 Fragaria x ananassa Artemisia absinthium 25.6 Fragaria x ananassa Artemisia dracumulus 31.3 Fragaria x ananassa Artemisia dracumulus 22.3 Passiflora spp. Aster 2O.9 Passiflora spp. Avena Sativa 1OO.O Passiflora spp. Averrhoa caramboia 25.8 Fucus vesiculosus Beta vulgaris 1OO.O GainSoga ciliata Beta vulgaris 59.3 Gaultheria hispidula Beta vulgaris 41.4 Gentiana macrophylla Betula glandulosa 618 Bronius inermis Boesenbergia rotunda 36.9 Canna edulis Boesenbergia rotunda 42.5 Capsicum annuum Boletus edulis 43.1 Carex morrowii Borago officinalis 36.3 Carex morrowii US 2004/0175439 A1 Sep. 9, 2004 73

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HLE HLE Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Carya cordiformis 28.8 Schizonepeta tenuifolia 21.1 Carya cordiformis 21.0 Onobrychis viciifolia 42.6 Carya cordiformis 88.7 Origanum vulgare 53.8 Clematis armandii 20.1 Oryza Sativa 33.3 Chaerophyllum bulbosum 22.8 Oxalis Deppei 30.8 Chaerophyllum bulbosum 24.3 Panicum miliaceum 21.2 Agaricus bisporatus 25.4 Pastinaca Satiya 53.9 Chelidonium maius 39.0 Pastinaca Satiya 20.8 Chenopodium bonus-henricus 44.3 Pastinaca Satiya 26.9 chrysanthemum coronarium 33.4 Petroselinum crispum 58.2 chrysanthemum coronarium 23.9 Phaseolus coccineus 27.1 Cichorium endivia Subs. Endivia 44.3 Phaseolus vulgaris 37.9 Cichorium endivia Subs. Endivia 20.5 Phaseolus vulgaris 22.2 Circium arvense 49.7 Phaseolus vulgaris 23.2 Citrulius colocynthis 37.O Phlox paniculata 21.3 Hibiscus cannabinus 39.9 Physalis pruinosa 35.2 Hibiscus cannabinus 21.1 Phytolacca americana 1OO.O Huniulus lupulus 54.8 Plantago Coronopus 21.2 Huniulus lupulus 50.5 Plantago Coronopus 48.2 Hydrastis canadensis 20.5 Poa pratensis 50.7 Hypericum henryi 32.5 Podophyllum peltatum 27.9 Hypericum perforatum 27.9 Polygonum chinense 25.0 Hypericum sp 55.9 Polygonum aviculare 26.0 Hypomyces lactifluorum 42.7 Polygonum aviculare 1OO.O Iberis anara 1OO.O Polygonum pensylvanicum 42.3 Inula helenium 30.1 Polygonum persicaria 28.8 Ipomoia batatas 27.4 Populus incrassata 1OO.O Ipomoia batatas Populus Tremula 48.5 Juniperus communis Populus X petrowskyana 44.1 Laportea Canadensis Populus X petrowskyana 1OO.O Laurus nobilis 3 Populus X petrowskyana 72.O Laurus nobilis Portulaca oleracera 33.7 Lavandula angustifolia Poterium Sanguisorba 1OO.O Lavandula angustifolia Prunus spp. 39.6 Lavandula latifolia Prunus persica 21.4 Lavandula latifolia Prunus persica 26.6 Ledum groenlandicum Psidium guaiava 37.7 Lentinus edodes Psoralea corylifolia 51.5 Leonurus cardiaca Pteridium aquilinum 76.2 Lepidium Sativum Pteridium aquilinum 27.9 Levisticum officinale Punica granatun 66.4 Litchi chinensis mentha arvensis 34.O Lolium multiflorum 1.1.1. Mentha piperita 60.1 Lolium perenne Mentha pullegium 24.5 Lonicera ranosissina Mentha pullegium 24.8 Lupinus polyphyllius Mentha Spicata 24.4 Lupinus polyphyllius Mentha Suaveolens 28.9 Luzula Sylvatica Monarda didyma 54.7 Majorana hortensis 2 O. Musa paradisiaca 21.4 Malus spp. 37.8 Musa paradisiaca 32.8 Malus spp. nasturtium officinale 1OO.O Maius hupehensis Nepeta cataria 60.1 Melaleuca alternifolia Nepeta cataria 23.4 Melissa officinalis Nigella Sativa 23.2 Ginkgo biloba Agaricus bisporatus 25.8 Glycyrrhiza glabra Psidium spp. 28.3 Glycyrrhiza glabra Pleurotus spp. 31.6 Glycyrrhiza glabra Citrus reticulata 32.7 Gossypium herbaceum Citrus reticulata 29.4 Gossypium herbaceum Ocinum Basilicum 3O.7 Guizotia abyssinica Ocinum Basilicum 30.9 Hamamelis virginiana Ocinum Basilicum 39.1 Hamamelis virginiana Oenothera biennis 29.6 Hedeoma pullegioides Oenothera biennis 24.2 Hedeoma pullegioides Oenothera biennis 58.6 Helenium hoopesii Rubus occidentalis 93.2 Helenium hoopesii Rubus occidentalis 42.1 Helianthus tuberosus Rubus occidentalis 20.5 Helichrysum thianschanicum Runnex acetoSella 44.9 Helichrysum thianschanicum Rumex crispus 31.3 Helleborus niger Rumex crispus 1OO.O Schizonepeta tenuifolia Rumex crispus 20.8 US 2004/0175439 A1 Sep. 9, 2004 74

TABLE 10-continued TABLE 10-continued

HLE HLE Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Ruta graveolens 24.1 Symphytum officinale 80.2 Serenoa repens 28.5 Fragariax ananassa 97.9 Salvia Officinalis 66.5 Fragariax ananassa 93.8 Salvia Officinalis 54.O Vaccinium corymbosum 58.6 Salvia Officinalis 47.2 Vaccinium augustifolium 71.8 Sambucus Canadensis 23.2 Vaccinium augustifolium 53.6 Sambucus Canadensis 35.O Vitis 62.5 Sambucus Canadensis 32.6 Vitis 79.4 Sambucus Canadensis 54.O Petasites japonicus 56.5 Sanguisorba minor SO.O Petasites japonicus 53.0 Santolina Chamaecyparissus 75.8 Nicotiana rustica 61.1 Santolina Chamaecyparissus 33.3 Pysalis ivocarpa 53.8 Serratula tinctoria 36.3 Pteridium aquilinum 69.2 Datura metel 36.9 Pteridium aquilinum 66.2 Datura metel 21.4 Pteridium aquilinum 56.3 Satureia montana 1OO.O Sorghum durra 21.6 Satureia montana 66.8 Sorghun Sudanense 23.7 Satureia repandra 87.4 Stachys byzantina 25.3 Scorzorera hispanica 42.3 Stellaria graminea 27.6 Scorzorera hispanica 20.8 Stellaria graminea 36.7 Scutellaria lateriflora 36.O Stellaria media 22.6 Sium Sisarun 22.1 Stipa capiliata 36.7 Soianum melongena 22.4 Symphytum officinale 20.6 Solidago sp 22.6 Symphytum officinale 25.0 Sonchus oleraceus 4.1.8 Tanacetum cinerariifolium 24.9 Sorghum caffronun 23.O Tanacetum vulgare 46.4 Sorghum dochna 30.3 Tanacetum vulgare 32.O Sorghum dochna 53.5 Taraxacum officinale 63.1 Rehmannia glutinosa 83.O Thlaspi arvense 32.5 Frangula ainus 40.7 Thymus fragantissinus 36.7 Raphanus Sativus 36.5 Thymus fragantissinus 1OO.O Raphanus Sativus 22.4 Thymus praecox subsp arcticus 38.7 Reseda luteola 23.6 Thymus pseudoianuginosus 21.5 Reseda Odorata 20.3 Thymus vulgaris 2O.O Frangula ainus 65.3 Triticosecale spp. 26.0 Rheum officinale 1OO.O Triticium aestivium 2O.9 Rheum officinale 33.3 Triticum turgidium 49.4 Rheum X cultorum 34.O Triticum spelta 35.O Ricinius communis 27.5 Tropaeoium nails 23.5 Ribes GroSSularia 24.8 Tsuga diversifolia 34.3 Ribes nidigrolaria 24.4 TSuga mertensiana 32.8 Ribes nigrum SO.1 Typha latifolia 36.1 Ribes nigrum 23.8 Urtica dioica 32.8 Ribes nigrum 64.1 Achillea ptarmica 543 Ribes Sylvestre 32.4 Achillea ptarmica 64.3 Rosa rugosa 1OO.O Geranium pratense 93.4 RoSmarinus officinalis 75.8 Geranium pratense 98.5 RoSmarinus officinalis 46.6 Geranium pratense 97.4 Rubus idaeus 27.6 Thalictrum aquilegiifolium 53.6 Rubus idaeus 24.3 Thalictrum aquilegiifolium 60.4 Rubus idaeus 35.5 Veronica spicata 55.9 Vaccinium angustifolium 33.7 Veronica spicata 59.2 Vaccinium macrocarpon 24.1 Veronica spicata 56.2 Vaccinium macrocarpon 30.3 Helenium spp. 55.7 Vaccinium macrocarpon 70.9 Salvia Sylvestris 77.4 Vaccinium macrocarpon 57.2 Salvia Sylvestris 66.9 Valeriana officinalis 26.O Salvia Sylvestris 55.0 Valerianella locusta 53.7 Salvia regeliana 62.6 Verbascum thapsus 22.8 Crambe cordifolia 56.3 Verbascum thapsus 25.2 Crambe cordifolia 56.7 Veronica officinalis 29.9 Rudbeckia maxina 68.4 Vitis 39.1 Trollius x cultorum 97.6 Vitis 40.O Trollius x cultorum 93.2 Vitis 23.5 Vitis 26.4 Trollius x cultorum 100.1 Weigela coraeensis 20.1 Ansonia tabernaemontana 53.2 Weigela hortensis 25.3 Oenothera fruticosa spp. 109.8 Xanthium Sibiricum 28.4 Oenothera fruticosa spp. 61.3 Zea mayS 38.4 Oenothera fruticosa spp. 97.5 Oenothera biennis 8O.3 Oenothera fruticosa spp. 105.9 Alchemilia mollis 96.O Veronica austriaca ssp. 68.6 Alchemilia mollis 87.2 teucrium US 2004/0175439 A1 Sep. 9, 2004 75

TABLE 10-continued TABLE 10-continued

HLE HLE Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Veronica austriaca ssp. G O 58.1 Filipendula vulgaris G R 96.3 teucrium Geranium Sanguineun T R 89.4 Coreopsis verticillata T R 55.6 Geranium Sanguineun T O 6.3.3 Coreopsis verticillata G O 70.4 Geranium Sanguineun A. R 82.6 Potentilla fruticosa T R 104.8 Geranium Sanguineun A. O 53.2 Potentilla fruticosa A. R 99.4 Garanium Sanguineun G R 88.8 Pteridium aquilinum G O 56.2 Garanium Sanguineun G O 57.7 Matteuccia pensylvanica T R 67.2 Philadelphus coronarius A. O 55.5 Matteuccia pensylvanica A. R 59.0 paeonia Suffruticosa T R 58.9 Ocimum tenuiflorum T O 54.8 paeonia Suffruticosa T O 52.1 Carthanus tinctorius A. R 50.9 Paeonia Suffruticosa A. R 73.8 Carthanus tinctorius G R 69.0 Paeonia Suffruticosa A. O 52.2 Ligustrum vulgare T O 87.O Paeonia Suffruticosa G R 58.7 Ligustrum vulgare A. O 76.2 Paeonia Suffruticosa G O SO.4 Ligustrum vulgare G O 85.7 Dahlia spp. T R 77.4 Maiva verticiliata T R 80.1 Begonia convolvulacea T O 69.8 Maiva verticiliata A. R 82.8 Begonia convolvulacea A. O 67.5 Maiva verticiliata G R 82.4 Begonia convolvulacea G O 72.6 Hamamelis virginiana T R 56.1 Begonia emini T O 72.8 ArctostaphyloS uva-ursi T R 74.8 Begonia emini A. O 77.2 ArctostaphyloS uva-ursi G R 86.O Begonia emini G O 75.4 Vicia faba T O 846 Begonia glabra T O 82.3 Sempervivum tectorum T O 57.3 Begonia nannii A. O 82.5 Sempervivum tectorum A. O 74.8 Begonia nannii G O 72.8 Sempervivum tectorum G O 52.3 Begonia polygonoides T O 79.0 Ajitga reptans T O 55.3 Begonia polygonoides A. O 748 Ajitga reptans A. O 52.3 Begonia polygonoides G O 73.2 Ajitga reptans G O 72.1 Fushia spp. T R 76.6 Phlox paniculata T O 66.2 Fushia spp. A. R 70.7 Ligularia dentata A. O 52.1 Fushia spp. G R 76.9 Ligularia dentata G R SO.8 Butomus unbellatus A. O 58.8 Ligularia dentata G O 52.6 Onoclea Sensibilis G O 54.7 Achillea ptarmica T O 50.9 Onoclea Sensibilis G R SO.1 Potentilla fruticosa G R 98.6 Pinus cenbra A. R 83.2 Vernonia gigantea A. R SO.4 Pinus cenbra G R 76.3 Vernonia gigantea A. O 62.3 Cornius Sericed T R 104.O Vernonia gigantea G R 51.2 Cornius Sericed A. O 53.4 Vernonia gigantea G O 50.7 Cornius Sericed A. R 91.8 Penstemon digitalis T R 64.5 Cornius Sericed G O 51.O Penstemon digitalis A. R 63.5 Cornius Sericed G R 98.5 Penstemon digitalis A. O 57.3 Hydrangea quercifolia T R 58.1 Penstemon digitalis G R 63.4 Solidago Caesia T R 6O.7 Penstemon digitalis G O 67.8 Solidago Caesia A. R 60.5 Malus spp. T R 56.1 Cornus aiba T R 98.9 Malus spp. T O 56.7 Cornus aiba A. R 106.7 Malus spp. A. R SO.8 Cornus aiba G R 85.3 Malus spp. G R 51.2 Carpinus Caroliniana T R 95.4 Hosta Sieboidiana G O 50.9 Carpinus Caroliniana A. R 86.2 Hanannelis mollis T R 99.1 Carpinus Caroliniana G R 94.5 Hanannelis mollis A. R 94.1 AStilbe chinensis T R 543 Hanannelis mollis G R 89.4 AStilbe chinensis G R 50.3 Chaenomeles x Superba T R 56.2 SymphoricarpoS albuS G R 52.0 Chaenomeles x Superba A. R 71.9 Euphorbia amygdaloides T R 103.8 Chaenomeles x Superba G R 66.6 Euphorbia amygdaloides A. R 75.2 Chaenomeles x Superba G O 52.O Euphorbia amygdaloides G R 71.3 Centaurea dealbata T R 50.9 Viburnum plicatum A. R 61.O Centaurea dealbata A. R 74.1 Viburnum plicatum G R 57.9 Paeonia spp. T R 79.8 Buxus microphylla T R 58.0 Paeonia spp. T O 58.6 AStilboides tabularis T R 104.2 Paeonia spp. A. R 79.6 AStilboides tabularis A. R 108.1 Paeonia spp. A. O 58.5 AStilboides tabularis G R 100.3 Paeonia spp. G R 82.O Staphylea trifolia A. R 63.6 Paeonia spp. G O 6O.O Bergenia x Schmidtii T R 100.5 Lysimachia clethroides T R 83.3 Bergenia x Schmidtii A. R 113.7 Lysimachia clethroides T O 64.3 Bergenia x Schmidtii G R 99.3 Lysimachia clethroides G R 85.8 Rodgersia podophylia T R 68.9 Lysimachia clethroides G O 67.8 Rodgersia podophylia A. R 59.4 Magnolia x loebneri T R 61.4 Rodgersia podophylia G R 56.5 Iberis Sempervirens T O 62.4 Geranium phaeum T R 92.7 Iberis Sempervirens G O 63.8 Geranium phaeum A. R 84.3 Filipendula vulgaris T R 98.3 Geranium phaeum G R 101.0 Filipendula vulgaris A. R 94.5 Rubus pubescens T R 71.5 US 2004/0175439 A1 Sep. 9, 2004 76

TABLE 10-continued TABLE 11-continued

HLE Clostripain Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Rubus pubescens 76.2 Beta vulgaris 37.2 Rubus pubescens 82.8 Brassica rapa 24.6 Taxus x media 60.1 Buddleja davidii 27.6 Taxus x media 61.6 Bupleurum falcatum 34.6 Taxus x media 52.3 Capsicum annuum 36.8 Geranium x cantabrigiense 106.1 Capsicum annuum 24.9 Geranium x cantabrigiense 94.2 Cotinus Coggy gria 21.0 Geranium x cantabrigiense 95.9 Kolkwitzia annabilis 27.9 Fuchia magellanica 100.2 Laserpitium latifolium 20.4 Fuchia magellanica 91.9 Lindera benzoin 38.6 Fuchia magellanica 102.2 Lolium perenne 34.7 Microbiata decussata 51.5 Miscanthus Saccharifiorus 39.9 Microbiata decussata 51.9 Ophiopogon japonicus 20.5 Rhododendron spp. 51.2 Phaseolus nungo 3O.O Stephanandra incisa 102.5 Phaseolus Vulgaris 36.4 Stephanandra incisa 104.6 Phaseolus Vulgaris 23.4 Stephanandra incisa 99.1 Plumbago zeylanica 26.5 Coryius maxina SO.8 Portulacea oleracea 22.2 Coryius maxina 57.1 Salix purpurea F. Gracilis 38.6 Cyperus alternifolius 58.2 Soianum melanoceraSun 26.0 Soleirolia Soleirolii 51.2 Stellaria media (linné) Cyrillo 31.6 Soleirolia Soleirolii 68.0 Tanacetum vulgare 35.3 Strelitzia reginae 106.5 Tanacetum vulgare 35.4 Strelitzia reginae 94.3 Trifolium incarnatum 22.0 Strelitzia reginae 111.7 Vaccinium augustifolium 34.O Hedychium coronarium 53.5 Zea Mays 21.9 Hedychium coronarium 86.9 Afranonun neiegueta 27.9 Hedychium coronarium 74.6 Allium Sativum 35.3 Strelitzia reginae 78.6 Anthenis nobilis 35.8 Strelitzia reginae 78.O Anthurium guildingii 55.2 Strelitzia reginae 107.3 AStilbex arendsii 25.6 SymphoricarpoS orbiculatus 58.7 Beta vulgaris 28.0 Rodgersia spp. 59.5 Campanula rapunculus 24.5 Rodgersia spp. 59.0 Cirsium arvense 3O.O Lania Strun galeobdoion 91.5 Cissus discolor 40.8 AStilbex arendsii 84.5 Coccoloba Caracasana 24.9 Clematis alpina 54.4 Convailaria maialis 28.5 Stewartia pseudocannellia 75.5 Cucurbita pepo 20.9 Stewartia pseudocannellia 84.1 Cucurbita pepo 42.5 Stewartia pseudocannellia 813 Errhenatherunn elatius 21.6 Pinus mugo 58.9 Filipendula rubra 44.3 Pinus mugo 53.7 Galium odoratum 31.2 Pinus mugo 61.7 Glycyrrhiza glabra 27.6 Rubus thibeianus 97.6 Hedychium sp. 35.6 Rubus thibeianus 97.9 Houttuynia Cordata 30.2 Rubus thibetanus 95.4 Lactuca Sativa 28.8 Rubus arcticus 89.3 Lactuca Sativa 21.6 Rubus arcticus 85.5 Lotus tetragonolobus 42.9 Rubus Phoenicolasius 93.2 Lycopersicon eSculentum 32.3 ribes annericanum 70.4 Lysimachia clethroides 22.7 Passiflora spp. 62.4 Magnolia Stellata 23.6 Rubus Occidentalis 70.9 Microlepia platyphylla 21.0 Nicotiana tabacunn 60.9 Miscanthus Saccharifiorus 25.6 Beta vulgaris 71.3 pastinaca Saiva 44.7 Phaseolus vulgaris 36.7 Pteridium aquilinum 22.2 Solidago sp? 40.8 Symphytum officinale 22.7 0.155) Tanacetum vulgare 31.4 Thymus fragantissuinus 20.1 TABLE 11 Urtica dioica 32.6 Zea mayS 22.4 Clostripain Abies balsannea 38.6 Allium anpeiopraSun 30.3 Nom latin Stress Extrait Inhibition (%) Allium Sativum 55.5 Anaranthus gangeticus 75.4 Achidinia arguta 34.1 Apium graveolens 21.7 Anthoxanthun Odoratun 35.O Aralia cordata 48.2 Apocynum cannabinun 47.6 Asclepias tuberosa 2O2 Arctium minus (Hill) 34.5 ASctinidia chinensis 47.7 Bernhardi Baptisla tinctoria SO.4 Beckmannia erucaeformis O 47.3 Betula alleghaniensis 24.9 US 2004/0175439 A1 Sep. 9, 2004 77

TABLE 11-continued TABLE 12-continued

Clostripain Subtilisin Nom latin Stress Extrait Inhibition (%) Nom latin Stress Extrait Inhibition (%) Brassica oleracea 21.4 Cichorium endivia G S 26.7 Brassica rapa 30.5 Cucurbita pepo G O 20.8 Caladium sp. 39.8 Echinacea purpurea G O 27.6 Carica papaya 23.8 Lactuca Sativa G O 36.4 Chaerophyllum bulbosum 24.3 pastinaca Sativa G S 52.1 Chrysanthenum coronarium 32.7 Pastinaca Satiya G S 20.1 Clematis chiisanensis 21.6 Ribes nigrum G O 41.2 Coccoloba Caracasana 40.1 Symphytum officinale G O 3O.O Cocos nucifera 22.5 Urtica dioica G O 38.2 Conus maS 34.2 Vitis sp. G S 22.3 Cucurbita pepo 24.9 Alchemilia mollis T S 22.6 Cymbopogon citratus 20.4 Aithacea officinalis T O 33.5 Forsythia x intermedia 44.0 Althaea officinalis T S 53.5 Heliotropium arborescens 27.1 Aralia cordata T S 21.0 Lonicera ranosissina 34.9 ASctinidia chinensis T O 38.6 Maius pranifolia 23.6 AStilboides tabularis T O 41.O Marrubium vulgare 49.3 Averrhoa caramboia T S 20.9 Miscanthus Sinensis Anchess 26.9 Baptisia tinctoria T O 25.5 Nephelium longana ou 42.6 Beta vulgaris T S 24.2 Euphoria longana Convailaria maialis T O 48.2 Psoralea corylifolia 54.O Datura Stranonium T O 27.3 Raphanus Sativus 21.4 DioScorea batatas T S 36.4 Ribes Nigrum 40.9 Eleusine Coracana T S 26.2 Rubus thibetanus 24.2 Fragaria x ananassa T O 39.5 Rumex acetosellalinné 35.2 Ginkgo biloba T O 98.8 Sechium edule 25.6 Heliotropium arborescens T O 35.2 Stachys macrantha 25.9 Hibiscus cannabinus T S 25.2 Tepary 34.9 Hypericum perforatum T O 30.3 Thymus vulgaris “Argenteus” 25.3 Ipomea batalas T S 22.1 Trifolium pratense 31.3 Lathyrus Sylvestris T S 21.8 Trollius x cultorum 26.5 Lonicera ranosissina T O 29.6 Uvularia perfoliata 38.3 Lonicera ranosissina T S 39.9 Vaccinium macrocarpon 39.2 Lonicera Syringantha T R 31.1 Verbena officinalis 46.2 Madia Sativa T O 27.5 Zea mayS 32.5 Monarda T O 28.2 Myrica pensylvanica 22.7 Ocinum Basilicum T S 27.2 24.4 Peucedanum Oreaselinum T S 29.2 Nicotiana tabacunn 22.8 Psoralea corylifolia T S 20.9 Paeonia 31.3 Rahminus franguia T O 26.4 pastinaca Sativa 29.2 Raphanus Sativus T S 25.5 Rheum rhabarbarium T S 21.6 Ribes Nigrum T R 28.9 Rubus occidentalis T S 22.8 RuneS Scutatus T S 21.4 0156) Solidago Hybrida T O 34.5 Tanacetum balsanila T O 33.9 TABLE 12 Vaccinium macrocarpon T O 81.2 Xanthium Sibiricum T S 31.7 Subtilisin Zea mayS T S 28.3 Nom latin Stress Extrait Inhibition (%) Actaea racemosa 20.6 We claim: Alchemilia mollis 23.5 1. An extract from a plant, comprising non-proteinaceous Borago officinalis 20.5 Capsicum annuum 24.7 molecules having protease inhibitor activity, which inhibits Cornus Canadensis L. 22.6 the activity of one or more extracellular proteases, wherein Genista multibracteata 21.3 the extract has been prepared by the Steps of harvesting plant Glycine max 26.0 Lolium perenne 75.9 material, treating plant material with a Solvent, Separating Matricaria reciutita 23.2 the resulting extract from the Solid material, testing an Phaseolus Vulgaris 34.7 aliquot of the extract against a panel of extracellular pro Prunus Tomentosa 20.4 teases, and retaining the extract if it inhibits the activity of Scuttellaria lateriflora 33.5 Solidago Canadensis 42.O one or more extracellular proteges. Spinacia oleracea 1OO.O 2. A library of plant extracts, comprising non-proteina Tanacetum vulgare 42.4 ceous molecules having protease inhibitor activity, wherein Tanacetum vulgare 26.7 each extract inhibits the activity of one or more extracellular Typha latifolia L 24.9 proteases. Zea mayS 2O.9 Zea Mays 34.7 3. A library of plant extracts, comprising non-proteina Adiantum pedatun 22.4 ceous molecules having protease inhibitor activity, formed by a process comprising: US 2004/0175439 A1 Sep. 9, 2004 78

(a) contacting plant material with either an aqueous, 6. A non-proteinaceous extracellular protease inhibitor ethanolic, or an organic Solvent; derived from a plant comprising the Steps of: (b) isolating an extract from said plant material; (a) contacting plant material with either an aqueous, (c) analysing Said extract for the presence of one or more ethanolic, or an organic Solvent; inhibitory activities against an extracellular protease; (b) isolating an extract from Said plant material; (d) and collected two or more extracts together, So as to (c) analysing said extract for the presence of one or more form a library of plant extracts wherein each extract inhibitory activities against a panel of extracellular inhibits one or Sore extracellular proteases. proteases, 4. A plant extract, comprising non-proteinaceous mol ecules having protease inhibitor activity, which inhibits the (d) further purifying a compound from said extract if said activity of one or more extracellular proteases, wherein Said extract demonstrates the inhibition of one or more plant has been Stressed prior to generating the extract. extracellular proteases greater than about 20%. 5. A library of plant extracts, comprising non-proteina 7. A method for increasing the levels of non-proeteina ceous molecules having protease inhibitor activity, wherein ceous extracellular protease inhibitors in plants comprising each extract inhibits the activity of one or more extracellular he step of Stressing the plant prior to forming a plant extract. proteases and wherein Said plants have been Stressed prior to generating the extract.