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AHCC, a culture extract to boost immune defence Based in Sapporo, AminoUp develops and manufactures bioactive substances One company’s innovation has attracted derived from natural products. interest in THE HEALTH POTENTIAL of a common food.

For thousands of years, shown its proprietary societies around the world mushroom culture extract, Dr Kohei Homma, executive have used for their trademarked as AHCC, gives senior director of business perceived beneficial effects on the immune system a natural development (left) and president and COO, Kentaro Kitadate in the human immune system. boost. AHCC has now been front of the AHCC culture tank. The famous Greek physician investigated for a variety of A mushroom culture extract, AHCC works as a ‘modulator’ of the human immune system. Hippocrates was among those applications in more than 100 that identified the mushroom scientific publications. also called hoof fungus or Fomes Kentaro Kitadate, president fomentarius as a species that and chief operating officer of the natural ability of foods that at AminoUp reported in the today; in Japan, rates of infection with results expected alternative approaches to and potentially to reduce the could reduce inflammation. AminoUp believes AHCC has positively affect human health. European Journal of Nutrition, cervical cancer incidence and to be published by 2021. immune system maintenance. use of strong antibiotics. Today, there is intense the potential to support the “In traditional Chinese stimulate specific receptors that mortality have been rising since “It is a mouse-model study. “AHCC induces our natural interest in using food to support health of an ageing population. medicine, mushrooms are located on human immune the 1990s. A GLOBAL VISION Mice are going to be infected defence, so does not go through the immune system, particularly “Our approach is to explore have been used to modify cells in the gut that recognize “While we have vaccines for AminoUp has funded laboratory with SARS-CoV-2 and the same mechanism as an to address the public health new possibilities from the immunity,” says Dr Kohei foreign pathogens such as HPV, there are fewer treatments studies on mice that have we will examine the mortality antibiotic. Therefore, resistance imperative of Japan’s rapidly power of nature, to induce the Homma, AminoUp’s executive and . for existing high-risk cases,” further revealed that AHCC change and other parameters should not be a problem,” ageing society. And foods that natural potential that we have senior director of business “AHCC is able to modulate says Homma. The research is effective at activating with and without AHCC says Homma. are purported to have specific in our body and to bring out development. “Our research and improve the non-specific led by Judith A. Smith at the immune cells against West administration,” says Homma. AminoUp’s vision is to see physiological benefits are under the innate strength in all living scientists were motivated to immune functions in our body University of Texas Health Nile virus, influenza, and He believes AHCC is also AHCC become a household scrutiny as researchers seek to things,” says Kitadate. understand the immunological to a range of risk factors,” Science Center at Houston avian flu. A clinical study in worth investigating for its name as a daily nutritional confirm their efficacy through benefit of mushrooms.” says Homma. McGovern Medical School, and Nutrition Research suggests that potential to help with some of supplement for immune clinical trials. INNOVATING FOR IMMUNITY AminoUp’s leading funded by AminoUp, revealed supplemental AHCC may boost the world’s other significant maintenance. Currently, AHCC Our immune system is central supplement, AHCC, was SEEKING OPTIONS FOR that AHCC could help clear the antibody titre when given health challenges, including is shipped to an estimated SCIENTISTS to our health, shielding us from launched in 1987, following an TREATMENT OF HPV HPV virus infection in cervical at the time of vaccination for the growing problem of 150,000 people in 40 countries AROUND THE pathogens, such as viruses, evaluation of more than 100 One of the promising cancer cell lines and mouse influenza B. antibiotic resistance. worldwide, and demand WORLD ARE bacteria, and toxins. As we different mushroom species, applications of AHCC is its models. Now, AminoUp has begun For example, ‘superbugs’, is growing. WORKING become older, our immune and systematically tested for potential as a nutritional The same team undertook a a collaboration with the bacteria that are resistant to “We may just be a small ON WAYS TO system becomes weaker. optimized manufacturing. supplement to help the preliminary clinical study of 10 University of Texas Medical all available antibiotics, are company in Japan,” says ENHANCE To help ageing populations, Derived from the cells of immune system to fight human women, persistently infected Branch, to assess whether expected to be responsible for Homma. “But we’re serious HUMAN scientists around the world are mushroom mycelia, and papillomavirus (HPV) infection. with high-risk HPV, that was AHCC could assist with global more deaths than cancer by about innovation.” IMMUNITY working on ways to enhance slowly cultured with a unique HPV infection is common, encouraging enough to lead to efforts to fight the SARS-CoV-2 2050, according to a review human immunity. mix of nutrients for nearly two but persistent infection with a larger clinical trial. Smith is virus through supporting the commissioned by the UK One supplement being AminoUp has worked to months, AHCC consists of a specific, high-risk types of HPV now undertaking a NIH-funded, immune system. Government. Homma says that scrutinised is produced by improve human immunity mix of mostly polysaccharides, can lead to cervical cancer, one double-blinded, placebo- In the absence of an available AHCC may help to support the AminoUp, a biotech company for more than 35 years. Its large sugar polymers. These of the most common cancers controlled study of 50 women vaccine against coronavirus, immune system to enable the in Sapporo, Japan, that has approach is simple: to enhance polysaccharides, researchers affecting women worldwide with persistent high-risk HPV there is broad interest in body to better fight infection, https://www.aminoup.jp/en/

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