DOCSLIB.ORG

World Journal of Dermatology

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
World Journal of Dermatology World Journal of W J D Dermatology Submit a Manuscript: http://www.wjgnet.com/esps/ World J Dermatol 2015 May 2; 4(2): 108-113 Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx ISSN 2218-6190 (online) DOI: 10.5314/wjd.v4.i2.108 © 2015 Baishideng Publishing Group Inc. All rights reserved.V MINIREVIEWS New innovation of moisturizers containing non-steroidal anti-inflammatory agents for atopic dermatitis Montree Udompataikul Montree Udompataikul, Skin Center, Srinakharinwirot experience. These moisturizers might be considered University, Bangkok 10110, Thailand as an alternative treatment in acute flare of mild to Author contributions: Udompataikul M contributed to this moderate atopic dermatitis. work. Conflict-of-interest:None. Key words: Non-steroidal anti-inflammatory agents; Open-Access: This article is an open-access article which was Moisturizer; Atopic dermatitis selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, © The Author(s) 2015. Published by Baishideng Publishing which permits others to distribute, remix, adapt, build upon this Group Inc. All rights reserved. work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and Core tip: The skin care management particular moisturizers the use is non-commercial. See: http://creativecommons.org/ play an important role in atopic dermatitis. The side effects licenses/by-nc/4.0/ of corticosteroids are limited in their use in this disease. Correspondence to: Montree Udompataikul, MD, Associate Take together, a new moisturizer containing various anti- Prefessor, Skin Center, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand. [email protected] inflammatory substances have been developed to be Telephone: +66-225-94260 used as an alternative treatment to avoid the side effects Received: September 15, 2014 of corticosteroids. These agents are divided into herbal Peer-review started: September 16, 2014 extracts, vitamins, minerals and lipids. The clinical trials on First decision: October 14, 2014 the effectiveness of these moisturizers were reviewed. The Revised: November 27, 2014 author’s clinical experience also discussed. Accepted: January 15, 2015 Article in press: January 19, 2015 Published online: May 2, 2015 Udompataikul M. New innovation of moisturizers containing non-steroidal anti-inflammatory agents for atopic dermatitis. World J Dermatol 2015; 4(2): 108-113 Available from: URL: http://www.wjgnet.com/2218-6190/full/v4/i2/108.htm DOI: Abstract http://dx.doi.org/10.5314/wjd.v4.i2.108 Atopic dermatitis is a chronic, relapsing and extremely pruritic eczematous disease which commonly affects children. The standard management consists of a combination of anti-inflammatory drugs in adjunctive INTRODUCTION with skin care management particular moisturizer application. A concern for the side effects associated Atopic dermatitis (AD) is a chronic, relapsing and with long term use of corticosteroids has also been extremely pruritic eczematous disease which commonly considered. There has been an emerging interest in affects children and influences the quality of life. moisturizer containing non-steroidal anti-inflammatory The etiology of AD seems to result from a combination agents such as herbal extracts, vitamins, mineral and of barrier dysfunction, immunodys function, genetics, lipids. The in vitro and the in vivo studies of each autoimmunity, Staphylococcus aureus and environmental agent were reviewed. The clinical study on the efficacy factors[1]. of moisturizers containing these agents were also The standard management of AD consists of a demonstrated including the author’s studies and clinical combination of anti-inflammatory drugs in adjunction WJD|www.wjgnet.com 108 May 2, 2015|Volume 4|Issue 2| Udompataikul M. Moisturizers for atopic dermatitis In 2010, Udompataikul et al[6], conducted a com- Table 1 Type of anti-inflammatory agents parative trial of moisturizer containing LA and linoleic Herbal extracts acid vs 1% hydrocortisone (HC) for the treatment Licorice of childhood AD. It was a randomized controlled- Glycyrrhiza inflate (Licochalcone A) investigator blind study. LA lotion were applied on one Glycyrrhiza glabra (Glycyrrhetinic acid) side of the patients’ body and HC lotion on the opposite Chamomile side, twice daily for 6 wk. The clinical outcome was Matricaria recutita (Bisabolol, chamazalene, apigenin) Vitamins and minerals assessed using the scoring of AD (SCORAD) score. The Provitamin B5 (Dexpanthenol) relapse rate was recorded and analysed using survival Vitamin B3 (Niacinamide) analysis. Thirty patients were enrolled, 26 patients Zinc completed the protocol. The mean age was 5.8 years Lipids Natural sources of lipids old. The average baseline SCORAD score was 28 on N-palmitoylethanolamide extracted from palm oil both sides (moderate severity). The response rate Linoleic acid extracted from: of both agents was 73.33%. There was no statistical Shea butter (Butyrospermum parkii) significant group difference in the reduction of SCORAD Canola oil score. Though the edema and erythema score in HC Argar oil Kernel oil treated area had more rapid improvement than that of Spent grain wax LA treated side, there was no significant difference. The Portulaca oleracea Linn relapse rate of HC-treated side was higher than that Phytosterol extracted from shea butter of LA-treated side. However, there was no significant Synthetic lipids Ceramides difference. No side effect was observed from both Pseudoceramides agents. It was concluded that the effectiveness of moisturizer containing LA was equal to that of HC lotion. It could be used as an alternative treatment for with skin moisturization and avoidance of triggering both acute flare and in maintainance phase of mild to factors. A concern for the side effects associated moderate childhood AD. with long term use of corticosteroids has also been There was also a multicenter, randomized,split- considered. side double blind study in 55 children between the For the past five years, there has been an emerging age of 3 mo to 14 years with mild to moderate AD. interest in moisturizer containing non-steroidal anti- It was shown that LA had a similar result in terms of inflammatory agents such as herbal extracts, vitamins, improved SCORAD and reduces transepidermal water [7] minerals and lipids. The anti-inflammatory property loss (TEWL) compared with 1% HC . [8] of these agents are demonstrated in in vitro, in vivo In 2014, Angelova-Fischer et al , designed a studies, as well as the clinical trials on the patients comparative study of moisturizer consisted of LA, linoleic with AD, psoriasis and seborrheic dermatitis. acid, decanediol and menthoxypropanediol (LALDM) From the literature reviews of clinical researches vs 1% HC for mild to moderate AD treatment. Twenty on these moisturizers, they are divided into 3 groups patients were included. The mean age was 26.2 years according to the active ingredients of anti-inflammatory old (16-65 years old). It was discovered that LALDM agents as follows: herbal extracts, vitamins, minerals and 1% HC can reduce SCORAD scores, pruritus, and lipids (Table 1). The evidence of the clinical studies erythema, TEWL and increase in skin conductance on the effectiveness of moisturizers containing anti- without statistically significant difference between two inflammatory agents are summarized in Table 2. groups. Moreover, LALDM can reduce Staphylococcus aureus colonization with statistically significant difference from 1% HC. Decanediol has antibacterial HERBAL EXTRACTS activity. Menthoxypropanediol, a synthetic derivative of There are two active ingredients extracted from two menthol can improve the pruritic symptom by triggering species of Licorice: (1) Licochalcone A (LA), extracted cold-sensitive receptors in the skin which is responsible from Glycyrrhiza inflate; and (2) Glycyrrhetinic acid, for cooling sensation. extracted from Glycyrrhiza glabra. Glycyrrhetinic acid also possesses anti-inflammatory There is an in vitro study that demonstrates that LA, property[9]. Abramovits et al[10], conducted a randomized, a major phenolic component of Glycyrrhiza inflate, has vehicle-controlled clinical trial to examine the effective- anti-inflammatory as well as antimicrobial effects[2,3]. ness of MASO63DP cream, which composed of shea It could inhibit cytokines production from T cells and butter and Glycyrrheticnic acid, in the management monocytes as well[2-4]. The study shows that LA could of mild to moderate AD. 218 patients, age between reduce shave-and ultraviolet (UV)-induced redness[4]. 18-84 years old, were included in this 50-d study. The Moreover, the improvement of the rosacea patients clinical outcomes were assessed using Eczema Area is also reported in a clinical study in which skin care and Severity Index score and Investigator’s Global product containing LA was applied for 8 wk[5]. Assessment. It was found that the incidence of rash WJD|www.wjgnet.com 109 May 2, 2015|Volume 4|Issue 2| Udompataikul M. Moisturizers for atopic dermatitis Table 2 Evidence of the clinical studies on the effectiveness of moisturizers containing anti-inflammatory agents Ref. Active ingredients Design + Population + Age Outcome measurement Results Udompataikul et al[6] Licochalcone A, LA Randomized controlled-investigator SCORAD score Response rate 73.33% The effective- blind; n = 28, mean
Load more

Recommended publications
  • Itch in Ethnic Populations
    Acta Derm Venereol 2010; 90: 227–234 REVIEW ARTICLE Itch in Ethnic Populations Hong Liang TEY1 and Gil YOSIPOVITCH2 1National Skin Centre, 1, Mandalay Road, Singapore, Singapore, and 2Department of Dermatology, Neurobiology & Anatomy, and Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA Racial and ethnic differences in the prevalence and clini- DIFFERENCES IN SKIN BIOLOGY AND ITCH cal characteristics of itch have rarely been studied. The aim of this review is to highlight possible associations Few studies have examined the differences between between ethnicity and different forms of chronic itch. We skin types in relation to ethnicity and neurobiology of provide a current review of the prevalence of different the skin. Differences between ethnic skin types and types of itch in ethnic populations. Genetic variation may skin properties may explain racial disparities seen in significantly affect receptors for itch as well as response pruritic dermatologic disorders. to anti-pruritic therapies. Primary cutaneous amyloido- sis, a type of pruritic dermatosis, is particularly common Epidermal structure and function in Asians and rare in Caucasians and African Ameri- cans, and this may relate to a genetic polymorphism in A recent study has shown that the skin surface and the Interleukin-31 receptor. Pruritus secondary to the melanocyte cytosol of darkly pigmented skin is more use of chloroquine for malaria is a common problem for acidic compared with those of type I–III skin (1). Serine African patients, but is not commonly reported in other protease enzymes, which have significant roles as pruri- ethnic groups. In patients with primary biliary cirrho- togens in atopic eczema and other chronic skin diseases, sis, pruritus is more common and more severe in African have been shown to be significantly reduced in black Americans and Hispanics compared with Caucasians.
    [Show full text]
  • Dermatologia 2021;96(4):397---407
    Anais Brasileiros de Dermatologia 2021;96(4):397---407 Anais Brasileiros de Dermatologia www.anaisdedermatologia.org.br CONTINUING MEDICAL EDUCATION Phototherapyଝ,ଝଝ ∗ Norami de Moura Barros , Lissiê Lunardi Sbroglio , Maria de Oliveira Buffara , Jessica Lana Conceic¸ão e Silva Baka , Allen de Souza Pessoa , Luna Azulay-Abulafia Department of Dermatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil Received 3 December 2019; accepted 2 March 2021 Available online 2 April 2021 Abstract Of all the therapeutic options available in Dermatology, few of them have the his- KEYWORDS tory, effectiveness, and safety of phototherapy. Heliotherapy, NB-UVB, PUVA, and UVA1 are Phototherapy; currently the most common types of phototherapy used. Although psoriasis is the most frequent PUVA therapy; indication, it is used for atopic dermatitis, vitiligo, cutaneous T-cell lymphoma, and cutaneous Ultraviolet therapy sclerosis, among others. Before indicating phototherapy, a complete patient assessment should be performed. Possible contraindications should be actively searched for and it is essential to assess whether the patient can come to the treatment center at least twice a week. One of the main method limitations is the difficulty that patients have to attend the sessions. This therapy usually occurs in association with other treatments: topical or systemic medications. Maintaining the regular monitoring of the patient is essential to identify and treat possible adverse effects. Phototherapy is recognized for its benefits and should be considered whenever possible. © 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana,˜ S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
    [Show full text]
  • European Guideline Chronic Pruritus Final Version
    EDF-Guidelines for Chronic Pruritus In cooperation with the European Academy of Dermatology and Venereology (EADV) and the Union Européenne des Médecins Spécialistes (UEMS) E Weisshaar1, JC Szepietowski2, U Darsow3, L Misery4, J Wallengren5, T Mettang6, U Gieler7, T Lotti8, J Lambert9, P Maisel10, M Streit11, M Greaves12, A Carmichael13, E Tschachler14, J Ring3, S Ständer15 University Hospital Heidelberg, Clinical Social Medicine, Environmental and Occupational Dermatology, Germany1, Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland2, Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany3, Department of Dermatology, University Hospital Brest, France4, Department of Dermatology, Lund University, Sweden5, German Clinic for Diagnostics, Nephrology, Wiesbaden, Germany6, Department of Psychosomatic Dermatology, Clinic for Psychosomatic Medicine, University of Giessen, Germany7, Department of Dermatology, University of Florence, Italy8, Department of Dermatology, University of Antwerpen, Belgium9, Department of General Medicine, University Hospital Muenster, Germany10, Department of Dermatology, Kantonsspital Aarau, Switzerland11, Department of Dermatology, St. Thomas Hospital Lambeth, London, UK12, Department of Dermatology, James Cook University Hospital Middlesbrough, UK13, Department of Dermatology, Medical University Vienna, Austria14, Department of Dermatology, Competence Center for Pruritus, University Hospital Muenster, Germany15 Corresponding author: Elke Weisshaar
    [Show full text]
  • Update of the Guideline on Chronic Pruritus
    Update of the Guideline on Chronic Pruritus Developed by the Guideline Subcommittee “Chronic Pruritus” of the European Dermatology Forum Subcommittee Members: Prof. Dr. Elke Weisshaar, Heidelberg (Germany) Prof. Dr. Sonja Ständer, Münster (Germany) Prof. Dr. Erwin Tschachler, Wien (Austria) Prof. Dr. Torello Lotti, Florence (Italy) Prof. Dr. Johannes Ring, Munich (Germany) Prof. Dr. Laurent Misery, Brest (France) Dr. Markus Streit, Aarau (Switzerland) Prof. Dr. Thomas Mettang, Wiesbaden (Germany) Prof. Dr. Jacek Szepietowski, Wroclaw (Poland) Prof. Dr. Joanna Wallengren, Lund (Sweden) Dr. Peter Maisel, Münster (Germany) Prof. Dr. Uwe Gieler, Gießen (Germany) Prof. Dr. Malcolm Greaves (Singapore) Prof. Dr. Ulf Darsow, Munich (Germany) Prof. Dr. Julien Lambert, Antwerp (Belgium) Members of EDF Guideline Committee: Prof. Dr. Werner Aberer, Graz (Austria) Prof. Dr. Dieter Metze, Münster (Germany) Prof. Dr. Martine Bagot, Paris (France) Dr. Kai Munte, Rotterdam (Netherlands) Prof. Dr. Nicole Basset-Seguin, Paris (France) Prof. Dr. Gilian Murphy, Dublin (Ireland) Prof. Dr. Ulrike Blume-Peytavi, Berlin (Germany) Prof. Dr. Martino Neumann, Rotterdam (Netherlands) Prof. Dr. Lasse Braathen, Bern (Switzerland) Prof. Dr. Tony Ormerod, Aberdeen (UK) Prof. Dr. Sergio Chimenti, Rome (Italy) Prof. Dr. Mauro Picardo, Rome (Italy) Prof. Dr. Alexander Enk, Heidelberg (Germany) Prof. Dr. Johannes Ring, Munich (Germany) Prof. Dr. Claudio Feliciani, Rome (Italy) Prof. Dr. Annamari Ranki, Helsinki (Finland) Prof. Dr. Claus Garbe, Tübingen (Germany) Prof. Dr. Berthold Rzany, Berlin (Germany) Prof. Dr. Harald Gollnick, Magdeburg (Germany) Prof. Dr. Rudolf Stadler, Minden (Germany) Prof. Dr. Gerd Gross, Rostock (Germany) Prof. Dr. Sonja Ständer, Münster (Germany) Prof. Dr. Vladimir Hegyi, Bratislava (Slovakia) Prof. Dr. Eggert Stockfleth, Berlin (Germany) Prof. Dr.
    [Show full text]
  • Pruritus Associated with Chronic Kidney Disease: a Comprehensive Literature Review
    Open Access Review Article DOI: 10.7759/cureus.5256 Pruritus Associated With Chronic Kidney Disease: A Comprehensive Literature Review Sanzida S. Swarna 1 , Kashif Aziz 2 , Tayyaba Zubair 3 , Nida Qadir 4 , Mehreen Khan 5 1. Internal Medicine, Sir Salimullah Medical College, Dhaka, BGD 2. Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA 3. Internal Medicine, Desai Medical Center, Ellicott City, MD, USA 4. Internal Medicine, Liaquat University of Medical and Health Sciences, Liaquat University Hospital Jamshoro, Hyderabad, PAK 5. Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington DC, USA Corresponding author: Kashif Aziz, [email protected] Abstract The prevalence of pruritus in chronic kidney disease (CKD) patients has varied over the years, and some studies suggest the prevalence may be coming down with more effective dialysis. Chronic kidney disease- associated pruritus (CKD-aP), previously called uremic pruritus, is a distressing symptom experienced by patients with mainly advanced chronic kidney disease. CKD-aP is associated with poor quality of life, depression, anxiety, sleep disturbance, and increased mortality. The incidence of CKD-aP is decreasing given improvements in dialysis treatments, but approximately 40% of patients with end-stage renal disease experience CKD-aP. While the pathogenesis of CKD-aP is not well understood, the interaction between non- myelinated C fibers and dermal mast cells plays an important role in precipitation and sensory stimulation. Other causes of CKD-aP include metabolic abnormalities such as abnormal serum calcium, parathyroid, and phosphate levels; an imbalance in opiate receptors is also an important factor. CKD-aP usually presents as large symmetric reddened areas of skin, often at night.
    [Show full text]
  • Views in Allergy and Immunology
    CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY Dermatology for the Allergist Dennis Kim, MD, and Richard Lockey, MD specific laboratory tests and pathognomonic skin findings do Abstract: Allergists/immunologists see patients with a variety of not exist (Table 1). skin disorders. Some, such as atopic and allergic contact dermatitis, There are 3 forms of AD: acute, subacute, and chronic. are caused by abnormal immunologic reactions, whereas others, Acute AD is characterized by intensely pruritic, erythematous such as seborrheic dermatitis or rosacea, lack an immunologic basis. papules associated with excoriations, vesiculations, and se- This review summarizes a select group of dermatologic problems rous exudates. Subacute AD is associated with erythematous, commonly encountered by an allergist/immunologist. excoriated, scaling papules. Chronic AD is associated with Key Words: dermatology, dermatitis, allergy, allergic, allergist, thickened lichenified skin and fibrotic papules. There is skin, disease considerable overlap of these 3 forms, especially with chronic (WAO Journal 2010; 3:202–215) AD, which can manifest in all 3 ways in the same patient. The relationship between AD and causative allergens is difficult to establish. However, clinical studies suggest that extrinsic factors can impact the course of disease. Therefore, in some cases, it is helpful to perform skin testing on foods INTRODUCTION that are commonly associated with food allergy (wheat, milk, llergists/immunologists see patients with a variety of skin soy, egg, peanut, tree nuts, molluscan, and crustaceous shell- Adisorders. Some, such as atopic and allergic contact fish) and aeroallergens to rule out allergic triggers that can dermatitis, are caused by abnormal immunologic reactions, sometimes exacerbate this disease.
    [Show full text]
  • Epidemiology of Itch: Adding to the Burden of Skin Morbidity
    Acta Derm Venereol 2009; 89: 339–350 REVIEW ARTICLE Epidemiology of Itch: Adding to the Burden of Skin Morbidity Elke WEISSHAAR1 and Florence DALGARD2 1Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University Hospital Heidelberg, Germany, 2Institute of General Practice and Community Medicine, University of Oslo, Norway, and Judge Baker Children Center, Harvard Medical School, Boston, MA, USA Itch is the most frequent symptom in dermatology and disease with environmental factors, to meet demand has been researched more extensively in recent years. and to investigate factors of importance in preventing Nevertheless, there are few true epidemiological studies disease in the population (2–4). Individuals presenting on itch. The aim of this paper is to review the current to doctors tend to have more severe disease, thus this state of research on the epidemiology of chronic itch in patient population represents the tip of the iceberg re- Western and non-Western populations. The electronic lative to ill-health at the community level (3, 5). databases PubMed, Medline and the Cochrane Library The aim of this paper is to review current knowledge were searched. Conference proceedings and national and of the distribution of chronic itch in different popula- international studies were included. It is difficult to com- tions. The electronic databases PubMed, Medline and pare existing studies due to differing methodology and the Cochrane Library were searched. The search terms lack of standardized measures. The symptom of itch is used were: itch, itching, and pruritus, plus all of these a challenge, not only to clinicians, but also within the terms in combination with dermatology, epidemiology, structure of regional health systems, and with regards community, psycho-social factors, and skin diseases.
    [Show full text]
  • Emerging Research in Chronic Pruritus: from Bedside to Bench and Back Again
    medicines Editorial Emerging Research in Chronic Pruritus: From Bedside to Bench and Back Again Kyle A. Williams and Shawn G. Kwatra * Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; [email protected] * Correspondence: [email protected]; Tel.: +1-410-955-5933 Received: 21 April 2020; Accepted: 26 April 2020; Published: 29 April 2020 Abstract: This Medicines special issue highlights emerging research spanning from epidemiology to diagnostic workup, pathogenesis, and therapeutics for patients suffering from chronic pruritus. The special issue contains 13 articles reporting relevant epidemiologic and experimental data on chronic pruritus. Keywords: pruritus; itch; treatment; therapeutic; pathogenesis; epidemiology 1. Introduction This editorial serves as an introduction to the special issue “Pathogenesis and Treatment of Chronic Pruritus” and contains an overview of various known causes of chronic pruritus and emerging therapeutics. Chronic pruritus is itch that lasts greater than six weeks and is associated with a variety of dermatologic, systemic, neurologic, and psychiatric etiologies. Itch negatively impacts patient quality of life and has devastating psychosocial consequences. The manuscripts published in this special issue are also a showcase of the current understanding of the pathogenesis of chronic pruritus, along with its epidemiology, diagnostic workup, and therapeutic approaches used to treat chronic pruritus. 2. Epidemiology Chronic pruritus can arise in association with many disease processes and affects many patient populations. Thus, epidemiologic studies are needed to gain a better understanding of the burden of disease. In this special issue, a cross-sectional study of over 18,000 itch patients seen at a tertiary care center showed that African American and female patients were more likely to experience pruritus than their white or male counterparts [1].
    [Show full text]
  • DF Winter 2020-21 28P Webready4
    A DERMATOLOGY FOUNDATION PUBLICATION SPONSORED BY ORTHO DERMATOLOGICS VOL. 39 NOS. 1 & 2 SPECIAL DOUBLE ISSUE WINTER 2020-21 DDEERRMMAATTOOLLOOGGYY ™ Also In This Issue Virtual Seaside Chats FOCUSFOCUS Coming Soon John E. Bournas— New DF Executive Director DF Clinical Symposia: Sun Pharma Award Funds Eye-Opening Proceedings 2020 Research in Autoimmune Disease ADVANCES IN DERMATOLOGY The annual DF Clinical Symposia is a highly regarded 3-day CME event created to share out- standing experts’ knowledge in formal plenary talks, Breakfast Roundtables, and interactive evening Therapeutics Forums. The 2020 Clinical Symposia just preceded the rapid rise of Covid-19 in the U.S. We are pleased to present this most recent Clinical Symposia as a double issue of Dermatology Focus capturing the riches of the plenary talks. The keynote— Melanoma Tumor Syndromes—precedes the 8 symposia: Cancer; Thinking Differently; Therapeutic Updates; Patient Care Pearls; Melanocytic Lesions; Psoriasis; Diagnostics; and Special Populations. Join us for this year’s virtual Clinical Symposia— CDKN2A/CDK4 Tumor Syndrome Seaside Chats—coming in April. • CDKN2A/CDK4: cyclin D-dependent kinases • Inactivating mutations in CDKN2A – Mainly target the p16 transcript – Suggests G1-S restriction is critical in melanoma checkpoint KEYNOTE ADDRESS – Phenotype replicated by activating CDK4 mutations • Mutation carriers: undergo skin exams 4x/year, pancreatic New Insights into Melanoma Tumor Syndromes cancer screening, and stringent sun protection Hensin Tsao, MD Introduction. Investigators are using genetic analysis to progress Known melanoma tumor syndromes. FAMM (CDKN2A/CDK4): toward several predictive goals in melanoma: identifying patients at Tsao discussed a patient in his 20s with substantial freckling, large high risk for developing dysplastic nevi and/or melanoma, identifying dysplastic nevi and many previous excisions, and more than 15 bona melanoma tumors that risk metastasizing, and identifying a given fide melanomas.
    [Show full text]
  • Pathogenesis and Treatment of Chronic Pruritus
    Pathogenesis and of Chronic Treatment Pruritus • Shawn G. Kwatra Pathogenesis and Treatment of Chronic Pruritus Edited by Shawn G. Kwatra Printed Edition of the Special Issue Published in Medicines www.mdpi.com/journal/medicines Pathogenesis and Treatment of Chronic Pruritus Pathogenesis and Treatment of Chronic Pruritus Editor Shawn G. Kwatra MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade • Manchester • Tokyo • Cluj • Tianjin Editor Shawn G. Kwatra Johns Hopkins University School of Medicine USA Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Medicines (ISSN 2305-6320) (available at: https://www.mdpi.com/journal/medicines/special issues/pathogenesis chronic pruritus). For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03943-100-7 (Hbk) ISBN 978-3-03943-101-4 (PDF) c 2020 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. Contents About the Editor .............................................. vii Kyle A. Williams and Shawn G. Kwatra Emerging Research in Chronic Pruritus: From Bedside to Bench and Back Again Reprinted from: Medicines 2020, 7, 24, doi:10.3390/medicines7050024 ...............
    [Show full text]
  • Dermatology Today and Tomorrow: from Symptom Control to Targeted Therapy
    DOI: 10.1111/jdv.15335 JEADV REVIEW ARTICLE Dermatology today and tomorrow: from symptom control to targeted therapy U. Blume-Peytavi,1 M. Bagot,2 D. Tennstedt,3 M. Saint Aroman,4,* E. Stockfleth,5 A. Zlotogorski,6 V. Mengeaud,7 A.M. Schmitt,8 C. Paul,9 H.W. Lim,10 V. Georgescu,11 B. Dreno 12 T. Nocera13 1Department of Dermatology and Allergy, Charite-Universit atsmedizin€ Berlin, Berlin, Germany 2Dermatology Department, Saint-Louis Hospital, AP-HP, Paris, France 3Department of Dermatology, Saint-Luc University Clinics, Brussels, Belgium 4A-Derma Dermatological Laboratoires, Pierre Fabre Dermo-Cosmetique, Lavaur, France 5Klinik fur€ Dermatologie, Venerologie und Allergologie St. Josef-Hospital, Ruhr-Universitat€ Bochum, Bochum, Germany 6Department of Dermatology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel 7Ducray Dermatological Laboratories, Pierre Fabre Dermo-Cosmetique, Lavaur, France 8Dermatology Innovation Unit, Pierre Fabre Research and Development Institute, Toulouse, France 9Dermatology Department, Larrey Hospital, UMR INSERM 1065, Paul Sabatier University, Toulouse, France 10Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA 11Avene Dermatological Laboratories, Pierre Fabre Dermo-Cosmetique, Lavaur, France 12Department of Dermato-Oncology, University Hospital, Nantes, France 13Department of Dermatology, Clinical Research and Development Center, Pierre Fabre Dermo-Cosmetique, Toulouse University Hospital, Toulouse, France *Correspondence: M. Saint Aroman. E-mail: [email protected] Abstract For many decades and until recently, medical approach to dermatologic diseases has been based on the physician’s ability to recognize and treat symptoms. Nowadays, advances in the understanding of the biology of diseases and in technologies for intervening against them have allowed physicians to diagnose and treat underlying disease pro- cesses rather than simply addressing the symptoms.
    [Show full text]
  • Healthcare Bulletin
    Happy New Year 2003 JANUARY 2003 VOL 11 NO 1 ISSN 1681-5552 healthcare bulletin ◆ Common Dermatological Disorders ◆ Eczema ◆ Pruritus ◆ Urticaria ◆ Product Profile: Oni® ◆ Glimpse of MSD Activities 2002 ◆ SQUARE in International Business ◆ Medical Updates Published as a service to medical professionals by JANUARY 2003 VOL 11 NO 1 IN THIS ISSUE: Common Dermatological Disorders ... Page 1 Eczema ... Page 3 Pruritus ... Page 7 Urticaria ... Page 12 Product Profile: Oni® ... Page 16 Glimpse of MSD Activities 2002 ... Page 17 From the Desk of Managing Editor SQUARE in International Business ... Page 19 Dear Doctor: Medical Updates ... Page 20 "! You have already noticed Greetings everyone and Happythe New SQUARE Year! Welcome to this edition of " the new look of this issue! We have updated our design to make it more enjoyable for you. Our vision and determination is to give you the most accurate, " is "Dermatology" special and includes reliable andthe easy SQUARE to understand health information every time. This “the SQUARE” issue of " updated information on common dermatological disorders, Managing Editor pruritus, eczema, urticaria. Besides, our regular features comprise, Omar Akramur Rab MBBS, FCGP, FIAGP, FRSH medical updates, product profile and others. Executive Editor We welcome your suggestions and comments to help us provide Latifa Nishat the highest quality and most useful service. In addition we MBBS appreciate all of the comments and feedback we have received Members of the Editorial Board from those who have taken the time to write. Muhammadul Haque We believe you will enjoy reading this publication and that MBA hope and A. H. Mahbub Alam the contents provided will prove helpful towardsSQUARE your goal of M Pharm, PhD optimum health! Shaokat Zaman MBBS We, on behalf of the management of Information Assistance pray that you have a safe and healthy life throughout all of Md.
    [Show full text]