Ryan Zarychanski BSc, BSc (Med), MD. MSc, FRCP(C) Associate Professor, Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care University of Manitoba. Winnipeg, Canada Hematologist and Clinician Scientist, Cancercare Manitoba. Winnipeg, Canada. Senior Scientist, Research Institute of Oncology and Hematology. Winnipeg, Canada. Lyonel G Israels, Professor of Hematology, University of Manitoba. ON2051 – 675 McDermot Ave. Winnipeg, Manitoba, Canada. R3E 0V9 Email: [email protected] Tel: 204.787.2993 Fax: 204.786.0196
CITIZENSHIP: Canadian LANGUAGES: English
CLINICAL EXPERTISE: Hematology, Critical Care, Epidemiology,
CLINICAL RESEARCH Anticoagulants, transfusion, massive transfusion, EXPERTISE: critical care, sepsis, hemolytic anemia
METHODOLOGIC RESEARCH Clinical trials, systemic reviews, meta-analysis EXPERTISE: propensity-adjusted analyses
EDUCATION
Masters of University of Ottawa – Epidemiology and Community Medicine Science (MSc.) Ottawa Hospital Research Institute (Ottawa, Canada) September 2006 – May 2010
Clinician Royal College of Physicians and Surgeons of Canada Investigator University of Ottawa (Ottawa, Canada) Program (CIP) September 2006 – September 2008
Critical Care University of Manitoba, Fellowship July 2004-June 2006
Haematology University of Manitoba/Cancer Care Manitoba Fellowship July 2003-June 2005
Internal University of Manitoba Medicine July 2000 – June 2003 Residency
M.D. University of Ottawa - Faculty of Medicine September 1995 - May 2000
B.Sc. Med. University of Manitoba - Faculty of Medicine May 1996 - August 1997
B.Sc. University of Manitoba - Faculty of Science September 1992 - May 1995 Ryan Zarychanski
PROFESSIONAL COURSES
Academic Health University of Manitoba and the Winnipeg Regional Health Sciences Leadership Authority Program Centre for Healthcare Innovation, Winnipeg, Canada October 2013 to March 2014
Acute Critical Events Royal College of Physicians & Surgeons of Canada Simulation (ACES) University of Calgary, Calgary, Alberta Course July 2005
CERTIFICATIONS
FRCPC Fellow of the Royal College of Physicians and Surgeons of Canada Internal Medicine, Haematology, Critical Care, & Clinical Investigator Programme
USMLE (1,2 & 3) Completed all three parts of the United States Medical Licensing Exam
MCC Medical Council of Canada. Granted December, 2001
ROYAL COLLEGE OF PHYSICIANS AND SURGEONS OF CANADA SPECIALTY CERTIFICATES
Clinician Investigator Programme – September 2008 Critical Care – September 2006 Haematology - September 2005 Internal Medicine – June 2004
PROFESSIONAL AFFILIATIONS
Canadian Critical Care Trials Group – Member Society of Critical Care Medicine – Member Canadian Intensive Care Foundation – Member
American Society of Hematology – Member International Society of Thrombosis and Haemostasis – Member
The Society for Clinical Trials – Member Canadian Society of Clinical Investigation – Member
Royal College of Physicians and Surgeons of Canada – Fellow College of Physicians and Surgeons of Manitoba – Member in good standing Ryan Zarychanski
EMPLOYMENT
05/2019 - PRESENT Associate Professor Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
2009 - PRESENT Hematologist and Clinician Scientist CancerCare Manitoba, Department of Medical Oncology & Haematology Winnipeg, Manitoba, Canada
AFFILIATIONS
2013 – PRESENT Senior Scientist Research Institute of Oncology and Hematology CancerCare Manitoba / University of Manitoba, Winnipeg, Canada
2009 - PRESENT Assistant Professor Rady Faculty of Health Sciences, Max Rady College of Medicine Department of Epidemiology and Community Health Sciences University of Manitoba, Winnipeg, Manitoba, Canada
PREVIOUS POSITIONS
01/2009 – 04/2019 Assistant Professor Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care University of Manitoba, Winnipeg, Manitoba, Canada
2011 – 2017 Director, Knowledge Synthesis Unit Centre for Health Care Innovation Winnipeg, Manitoba, Canada
2011 – 2017 Medical Director, Therapeutic Apheresis Program Winnipeg Regional Health Authority Winnipeg, Manitoba, Canada
2006-2008 Clinical Research Fellow University of Ottawa, and the Ottawa Hospital Research Institute Clinical Epidemiology Programme Supervisors: Paul Hébert, Dean Fergusson and Deborah Cook Ryan Zarychanski
Ottawa, Ontario, Canada
2004-2006 Clinical Fellow – Critical Care Medicine. University of Manitoba 2003-2005 Clinical Fellow – Haematology. University of Manitoba 2000-2003 Medical Resident – Internal Medicine. University of Manitoba Winnipeg, Manitoba. Canada Ryan Zarychanski
PEER REVIEW
(CCV – RESEARCH FUNDING APPLICATION ASSESSMENT ACTIVITIES) GRANT REVIEW Canadian Institutes of Health Research • 2019 Chair – RC1 committee (Nov 2019) • 2019 Chair – RC1 committee (May 2019) • 2018 Chair – RC1 committee (Nov 2018 • 2018 Scientific Officer – RC1 committee (March 2018) • 2017 Scientific Officer – RC1 committee (Nov 2017) • 2015 Randomized Controlled Trials (RC1) Committee • 2014 Randomized Controlled Trials (RC1) Committee (May 2014) • 2012 Randomized Controlled Trials (RC1) Committee (May 2012) • 2012 Randomized Controlled Trials (RC1) Committee (Dec 2012) • 2011 Randomized Controlled Trials (RC1) Committee (May 2011) • 2011 Randomized Controlled Trials (RC1) Committee (Dec 2011) • College of Reviewers (2014 – present)
Canadian Critical Care Trials Group • Internal Grant and Manuscript review (2010-present)
Research Manitoba • 2019 New Investigator Operating Grants • 2017 New Investigator Operating Grants
(CCV – JOURNAL REVIEW ACTIVITIES) MANUSCRIPT New England Journal of Medicine/NEJM (2015) REVIEW The Lancet (2013-Present) Cochrane Library (2013-Present) Intensive Care Medicine (2013-Present) Cancer Epidemiology (2012-Present) BMC Pulmonary Medicine (2012-Present) Annals of Internal Medicine (2011-Present) British Medical Journal (2010-Present) Canadian Medical Association Journal (2009-Present) Critical Care Medicine (2009-Present) International Journal of Infectious Disease (2009-Present) CHEST (2016 – Present)
(CCV – CONFERENCE REVIEW ACTIVITIES) CONFERENCE American Society of Hematology, 2009 ABSTRACTS American Society of Hematology, 2010 • Abstract review coordinator, Antithrombotic agents
(CCV – ORGANIZATIONAL REVIEW ACTIVITIES) BSC. MED University of Manitoba, 2011, 2012, 2016 ABSTRACTS Ryan Zarychanski
SUPERVISION AND MENTORSHIP
RESIDENTS, FELLOWS, AND POSTDOCTORAL TRAINEES
Neelan Sriranjan Platelet trajectories in septic 2019- Present Internal Medicine, shock Co-Primary supervisor Resident University of Manitoba (Winnipeg, Canada) Kelsey Uminski Concordance of ABG to 2017 – present Internal Medicine, conventional laboratory Primary Supervisor Resident hemoglobin values in critical University of Manitoba care (Winnipeg, Canada) Chantalle Menard Evaluation of a comprehensive 2017 – 2019 Hematology Fellow Massive Transfusion Protocol Primary Supervisor University of Manitoba Student Recognitions: (Winnipeg, Canada) First Prize (Oral) – Internal Medicine Resident Research Day (2018) Third Prize (Oral) – CancerCare Research Day (2018)
Brittany Perija Acquired Hemophilia: A 2016 – 2018 Internal Medicine, retrospective population based Primary Supervisor Resident cohort study Student Recognitions: University of Manitoba First Prize – CancerCare Research (Winnipeg, Canada) Day, 2016 First Prize – Internal Medicine, Research Day, 2017
Murdoch Leeies Post-intubation hypotension 2014 - 2015 Emergency Medicine, with ketamine and etomidate in Resident acute traumatic brain injury University of Manitoba patients who require ventilation (Winnipeg, Canada) Chantalle Menard Timing of thrombocytopenia in 2014 – 2016 Internal Medicine, patients with septic shock Primary Supervisor Resident (retrospective cohort study) Student Recognitions: University of Manitoba Second Prize – Internal Medicine (Winnipeg, Canada) Resident Research Day Third Prize – Cancercare Research Day Manuscript PUBLISHED (Critical Care Medicine) Ryan Zarychanski
Chantalle Menard Successful management of a 2014 – 2015 Internal Medicine, patient with hemophila A Primary Supervisor Resident requiring coronary artery bypass Manuscript PUBLISHED University of Manitoba grafting (case report) (Journal of Haemophilia) (Winnipeg, Canada)
Brett Houston HALO (unfractionated heparin 2014 – present Internal Medicine, to improve outcomes in septic Primary Co-Supervisor with Alison Resident shock) translational analysis Fox-Robichaud University of Toronto (Toronto, Canada) Jennifer Yamamoto Preoperative therapeutic 2013 Internal Medicine, apheresis for severe medically Primary Supervisor Resident refractory amiodarone-induced Manuscript PUBLISHED University of Manitoba thyrotoxicosis: a case report (Journal of Clinical Apheresis) (Winnipeg, Canada) Student Recognitions: Second Prize – CancerCare Research Day, 2013
Meghan Azad, Probiotic Supplementation 2013-2014 Post Doctoral Fellow During Pregnancy or Infancy for Primary Supervisor University of Alberta the Prevention of Wheeze and Manuscript PUBLISHED (Edmonton, Alberta) Asthma: A Systematic Review (British Journal of Medicine) and Meta-Analysis Owen Mooney Nucleated red blood cells as an 2012-2013 Critical Care Fellow independent predictor of ICU Primary Supervisor University of Manitoba mortality and ICU recidivism Manuscript under preparation (Winnipeg, Canada) Student Recognitions: First Prize – Internal Medicine Resident Research Day Dr. Emily Rimmer Clinical outcomes associated 2010-2012 Hematology Fellow with the use activated protein C: Primary Supervisor University of Manitoba A retrospective propensity Abstract accepted to SCCM (Winnipeg, Canada) matched study Manuscript PUBLISHED (Critical Care Medicine) Dr. Bryce Makar Massive Transfusion research 2009-2012 Emergency Medicine Program. (Retrospective cohort Primary Supervisor Resident, study) Abstract accepted to SCCM University of Manitoba 1st Manuscript under preparation (Winnipeg, Canada) Student Recognitions: Second Prize – CancerCare Research Day, 2011 Second Prize – CancerCare Research Day, 2012 Dr. James Paul Adverse Events Associated With 2010-2011 Oncology Fellow Bone Marrow Biopsy In a Primary Supervisor Ryan Zarychanski
University of Manitoba Resident Training Program Student Recognitions: (Winnipeg, Canada) First Prize – Internal Medicine Resident Research Day Dr. Mawash Saeed Classical Hodgkin’s lymphoma 2010-2011 Internal Medicine presenting with autoimmune Primary Supervisor Resident dysregulation and systemic Manuscript PUBLISHED University of Manitoba inflammation (case report) American Journal of Hematology (Winnipeg, Canada) Dr. Angela Desautels Acute promyelocytic leukemia 2011 Internal Medicine (APL) in the absence of Primary Supervisor Resident peripheral blood abnormalities Abstract/Poster presented at University of Manitoba (case report) Resident Research Day, 2011 (Winnipeg, Canada) Dr. Kanwal Kumar, The Impact of Twenty-Four 2008-2009 Cardiac Surgery Resident Hour In-House Intensivists on a Co-supervisor University of Manitoba Dedicated Cardiac Surgery Manuscript PUBLISHED (Winnipeg, Canada) Intensive Care Unit (Ann Thorac Surg) Ryan Zarychanski
GRADUATE – (MSC & PHD) TRAINEES
Thesis supervision to Graduate Students Sylvain Lother 2019 (MSc. Candidate) Co-Primary Supervisor Critical Care Resident University of Manitoba Project Funding Award: (Winnipeg, Canada) Hector Ma Research Award. Department of Internal Medicine, University of Manitoba Funds Awarded $16,000 Brett Houston Evaluation of transfusion rates 2017 – Present (PhD Candidate) and transfusion utilization and Primary Supervisor Hematology Resident effectiveness in high-risk non- University of Manitoba cardiac surgery Project Funding Award: (Winnipeg, Canada) (2019) HSC Foundation Operating grant Funds Awarded $70,000 Brett Houston, PI.
(2018) Manitoba Medical Services Foundation Operating Grant: Funds Awarded: $29,613 Brett Houston, PI.
Salary Funding Award: (2018) Samuel McLaughlin/MMSF Research & Education Fellowship Award in Medicine Funds Awarded: $50,780
Research Award: (2018) Hectar Ma Award in Research University of Manitoba Funds Awarded: $16,000
First Prize (Poster)– (2018) Internal Medicine, Resident Research Day Murdoch Leeies Intravenous Immunoglobulin 2015 – 2019 (MSc. Candidate) (IVIG) in Septic Shock Primary Supervisor Critical Care, Resident Project Funding Source: Ryan Zarychanski
University of Manitoba Samuel McLaughlin Award (Winnipeg, Canada) (2015) (in partnership with the Manitoba Medical Services Foundation) $35,000. Murdoch Leeies, PI
(2018) Anesthesia Oversight Committee Operating Grant. Winnipeg Manitoba. Funds awarded: $10,000
Emily Rimmer MD Evaluation of white blood cell 2011-Present (MSc. Candidate) trajectories in patients with Primary Supervisor University of Manitoba septic shock Project Funding Source: (Winnipeg, Manitoba) Canadian hemophilia society (2011) $75,000 Bayer Hemophilia Award Program (2012) $80,000 Christine Fedorow MD Efficacy and safety of fibrinogen 2012-2013 (MSc. Candidate) concentrates in cardiac surgery Student withdrew from the University of Manitoba graduate program (Winnipeg, Manitoba) Project (non thesis) supervision to Graduate Students Daryl Hurrie Efficacy of iron replacement 2013-2014 (PhD Candidate) therapy on fatigue and work Primary Supervisor for this University of Manitoba capacity in non-anemic adults project (Winnipeg, Manitoba) with iron depletion: a systematic Manuscript – PUBLISHED review of randomized controlled (Systematic Reviews( trials Student Recognitions: First Prize – Health Leisure and Human Performance Research Day, 2014 Jessica Dennis, The impact of Provincial helmet 2011-2013 Ph.D Candidate legislation on the rate of bicycle Primary Supervisor for this University of Toronto related head injuries among project (Toronto, Canada) children and adults Manuscript – PUBLISHED (British Medical Journal) Jessica Dennis, The Effects of Provincial 2008- 2010 Masters Student Bicycle Helmet Legislation on Primary Supervisor for this University of Ottawa Helmet Use and Recreational project (Ottawa, Canada) Bicycle Ridership in Canada. Manuscript PUBLISHED (Injury Prevention) Ryan Zarychanski
BSC. (MED) SUPERVISION
Brett Houston Phenotypic and genotypic 2010-2012 Medical Student, evaluation of a Manitoba Role: Primary Supervisor University if Manitoba kindred with haemolytic Manuscript PUBLISHED BSc. Med anaemia associated with (Red Cells Molecules and Diseases) (Winnipeg, Canada) decreased osmotic fragility. Manuscript PUBLISHED (Blood)
Mutations in the Project Funding Source: mechanotransduction protein • Operating grant from the PIEZO1 are associated with Manitoba Medical Services hereditary xerocytosis Foundation ($20,000) • Student Recognitions: • Travel award to American Society of Hematology (ASH), 2010 ($500) • ASH Trainee Award ($5000) • ASH abstracts, 2010 and 2011 • Manuscript accepted for publication • First Prize – CancerCare Research Day, 2011 • Best Clinical BSc. (Med) project – University of Manitoba • Best Dissertation with the Most Significant Merit (BSc. (Med) – University of Manitoba) • Travel award to the National Student Research Forum (Galveston, TX) 2012 • First Prize – CancerCare Research Day, 2012 • Second Prize – U.S. National Student Research Forum • Winner – Oral Presentation – Canadian national Medical Student Research Symposium
Ryan Zarychanski
MEDICAL STUDENT SUPERVISION
Anna Blankstein Transfusion In Orthopedic 2019-Present (Med II) Surgery: A Multicentre Primary Supervisor University of Manitoba Retrospective Cohort Study (Winnipeg, Canada) Med II research prgm. Laurel Grant Association of diary 2017 (Med II) consumption and incident Co-Primary Supervisor University of Manitoba cancer: An overview of reviews (Winnipeg, Canada) Med II research prgm. Muzeen Ismath Evaluation of a massive 2017 (Med II) transfusion protocol Primary Supervisor University of Manitoba Project Funding Source: (Winnipeg, Canada) $6000 salary support from the Med II research prgm. University of Manitoba (Med II summer student research program) Patrick Boreskie Management of massive 2014 (Med II) transfusion in Cardiac Surgery Primary Supervisor University of Manitoba Manuscript under preparation (Winnipeg, Canada) Med II research prgm. Jessica Cudmore Methotrexate toxicity in a 2010-2011 (Med IV) patient with ulcerative colitis Primary Supervisor University of Manitoba (Winnipeg, Canada) Manuscript PUBLISHED Canadian Family Physician Allison Stasiuk Sedation and analgesia usage in 2009-2010 (Med II) / Pharmacist severe H1N1 (2009) infection Primary Supervisor University of Manitoba (Winnipeg, Manitoba) Manuscript PUBLISHED Annals of Pharmacotherapy
UNDERGRADUATE STUDENT SUPERVISION
Emily Krupka Tranexamic to reduce red cell 2017 (Bachelors of Science) transfusion in major non-cardiac Primary Supervisor University of Manitoba surgery Project Funding Source: (Winnipeg, Canada) CCMB Summer Studentship Award ($6000) Heather Wittick Regulators of iron overload in 2012-2013 (Bachelors of Science) patients with hereditary Primary Supervisor University of Winnipeg xerocytosis Abstract accepted to American (Winnipeg, Canada) Society of Hematology (ASH), 2013 Ryan Zarychanski
RESEARCH FUNDING HISTORY:
FUNDING: REQUESTED/UNDER REVIEW
Ryan Zarychanski
FUNDING: AWARDED
May 2019 Integrating clinical data systems to improve the capacity, performance, and value of Manitoba’s healthcare system PRINCIPAL APPLICANTS: Ryan Zarychanski (Nominated), Paul Komenda, Marshall Pitz, PRINCIPAL KNOWLEDGE USERS: Patients: Kim Mozil, Angela Tessier Clinicians: Piotr Czaykowski, Chris Christodoulou, Claudio Rigatto Decision-Makers: Jeanette Edwards, Deb Malazdrewicz, Brock Wright CO-APPLICANTS: Navdeep Tangri, Kathleen Decker, Dean Ferguson, Lisa Lix, Terry Klassen, James Bolton Alan Katz, Josee Lavoie, Eric Bohm KNOWLEDGE USERS: Decision-Makers: Charles Musuka, Chantale Pambrun, Mauro Verrelli, Matthew Seftel Clinicians: Thomas Mutter, Jason Park, Pamela Skrabek, James Zacharias, Clara Bohm, David Dawe Patients: Mac Horsburgh, Blair Waldvogel, Arlene Desjarlais, Kathryne Grisim, Jan Harris COLLABORATORS : Jim Slater, Perry Poulsen, Tom Ferguson, Eric Jacobsohn, Hema Bagry, Alain Beaudry Sean Armstrong, Pascal Lambert, John Ioculano, Sarah Kirby Funding Source: Canadian Institute of Health Research (CIHR); SPOR iCT Rewarding Success - Phase 3 – Team Grant TOTAL FUNDING: $6,108,118 CIHR Funds Awarded: $2,400,000 Matched Partnership Funding: $2,400,000 - Manitoba Health, Seniors and Active Living (MSHAL) ($1,800,000 in-kind + $600,000 in cash) In kind Partnership contributions: Centre for Healthcare Innovation $425,000; CancerCare Manitoba ($240,000); Manitoba eHealth Services ($219,018); Shared Health ($200,000); University of Manitoba $100,000; Chronic Disease Innovation Centre ($52,000); Bioscience Association Manitoba ($47,500); Research Manitoba ($12,600); Manitoba Renal Program ($12,000); Varian Medical Systems (confidential) Funding duration: 4 years
May 2019 Tranexamic acid use to safely reduce transfusion in major non-cardiac surgery (TRACTION): A pragmatic, registry-based, pilot randomized controlled trial Principal applicant: Brett Houston Co-Applicants: Zarychanski R, Mutter T, Jacobsohn E, Buduhan G, Falk J, Balshaw R Collaborators: Christodoulou C, McPherson J, Muirhead B, Haberman C, Horsburgh M Ryan Zarychanski
Funding: Health Sciences Centre Foundation; Operating Grant: Funds Awarded: $70,000 Years: 2
May 2019 Therapeutic Plasma Exchange in Septic Shock (PLEXIS): A pilot randomized trial Principal applicant: Emily Rimmer Co-Applicants: Zarychanski R, Houston DS, Wilkins J, Balshaw R, Kumar A Funding: Health Sciences Centre Foundation; Operating Grant: Funds Awarded: $70,000 Years: 2
November 2018 Tranexamic acid to reduce red blood cell transfusion in major non- cardiac surgery (TRACTION): A pragmatic, registry-based, pilot, randomized controlled trial Nominated Principal Applicant: Ryan Zarychanski Principal Applicants: Dean Fergusson, Rodney Breau, Thomas Mutter, Daniel McIsaac Co-applicants: Abdallah F, Bagry H, Beaule P, Buduhan G, Daya J, Haberman C, Horsburgh M, Houston BL, Jacobsohn R, Jetty P, Kanji S, Lalu M, Martel G, Park J, Taljaard M, Thavorn K, Tinmouth A, Turgeon AF, Wilson K Knowledge Users: Callum J Collaborators: Christodoulou C, Dhalla I, Girling L, McCartney C, McPherson J, Muirhead B, Pambrun C, Funding: Canadian Institute of Health Research (CIHR); SPOR iCT operating grant. Funds Awarded: $100,000 Years: 1
December 2018 Heparin anticoagulation to improve outcomes in septic shock (HALO): Investigator and Research Coordinator Meeting: Principal Applicant: Ryan Zarychanski Funding: Canadian Institute of Health Research (CIHR); Planning and Dissemination Grant Funds Awarded: $10,000 Years: 1
March 2018 Patient and Public Engagement Award. Related to: Intravenous Immune Globulin in Septic Shock (InVIGIS) to Improve Outcomes in Patients with Life-Threatening Infection Principal Investigator: Murdoch Leeies (MSc. candidate) Co Applicants: Zarychanski R (Supervisor) Funding: George and Fay Yee Centre for Healthcare Innovation (Joint funding by: Canadian Institute of Health Research (CIHR), University of Manitoba, Winnipeg Regional Health Authority, and the Government of Manitoba) Funds Awarded: $2,000 Ryan Zarychanski
Years: 1
February 2018 Integrating clinical data systems to improve the capacity, performance, and value of Manitoba’s healthcare system Principal Applicants/Researchers: Ryan Zarychanski (Nominated), Marshall Pitz, Alan Katz, Josée Lavoie, James Bolton, Lisa Lix, Terry Klassen Principal Knowledge Users: Patients: Donna Forbes, Angela Tessier Clinicians: Piotr Czaykowski, Alex Singer, Jitender Sareen, Thomas Mutter Decision-Makers: Deborah Malazdrewicz, Jeanette Edwards Collaborators: Dan Skwarchuk, Brock Wright, Sri Navaratnam, Frank Krupka Funding: Canadian Institute of Health Research (CIHR); Operating Grant: SPOR iCT Rewarding Success, Idea Brief Funds Awarded: $100,000 Years: 1
January 2018 Intravenous immune globulin in septic shock: A Canadian national survey Primary investigators: Faisal Siddiqui (nominated), Murdoch Leeies, Ryan Zarychanski Co-applicants: Turgeon AF, Marshall JC, Fowler R, Kumar A, Garland A, Gershengorn H, Charbonney E, Fergusson D, Cowan J, Paunovic B, Embil J, Cameron W, Murthy S Funding: Anesthesia Oversight Committee Operating Grant. Winnipeg Manitoba. Funds awarded: $10,000 Duration: 2 years.
December 2017 Integrating clinical data systems to improve the capacity, performance, and value of Manitoba’s healthcare system Principal Applicants/Researchers: Ryan Zarychanski (Nominated), Marshall Pitz, Alan Katz, Josée Lavoie, James Bolton, Lisa Lix, Terry Klassen Principal Knowledge Users: Patients: Donna Forbes, Angela Tessier Clinicians: Piotr Czaykowski, Alex Singer, Jitender Sareen, Thomas Mutter Decision-Makers: Deborah Malazdrewicz, Jeanette Edwards Collaborators: Dan Skwarchuk, Brock Wright, Sri Navaratnam, Frank Krupka Funding: Canadian Institute of Health Research (CIHR); Operating Grant: SPOR iCT Rewarding Success, Idea Brief Funds Awarded: $2,500 Years: 1
December 2017 Reducing transfusion while preserving Canada’s blood supply: The use and effectiveness of tranexamic acid in major non-cardiac surgical procedures at high-risk of bleeding Principal Investigator: Brett Houston (PhD candidate) Co Applicants: Zarychanski R (Supervisor), Garland A, Mutter T, Park J Ryan Zarychanski
Funding: Manitoba Medical Services Foundation (MMSF) Funds Awarded: $29,613 Years: 1
December 2017 Effectiveness of interventions and strategies to reduce emergency department wait times: A systematic review and meta-analysis Principal Investigator: Maya Jeyaraman Co Applicants: Abou-Setta AM, Rabbani R, Zarychanski R Funding: Manitoba Medical Services Foundation (MMSF) Funds Awarded: $30,000 Years: 1
July 2017 Patient and Public Engagement Award. Related to: A Multicentre, double blind, randomized, placebo controlled pilot trial to determine whether administration of tranexamic acid (TXA) reduces blood transfusion in patients undergoing major non-cardiac surgery Principal Investigator: Brett Houston (PhD candidate) Co Applicants: Zarychanski R (Supervisor) Funding: George and Fay Yee Centre for Healthcare Innovation (Joint funding by: Canadian Institute of Health Research (CIHR), University of Manitoba, Winnipeg Regional Health Authority, and the Government of Manitoba) Funds Awarded: $2,000 Years: 1
June 2017 Heparin anticoagulation to improve outcomes in septic shock: The HALO International Phase II efficacy RCT Principal Investigators: Ryan Zarychanski (Nominated), Dean Fergusson, Anand Kumar Co Applicants: Alejandria M, Yvette Barez, Cook DJ, Turgeon AF, Marshall JC, Fox-Robichaud A, McIntyre LA, Ramsay T, Green R, Leeies M Collaborators: Alavaren H, Buensalido JA, Chua MM, Garland A, Gopalan D, Iyer S, Jurao L, Palo JE, Panaligan M, Podolchuk H, Roxas E, Torno L, Zamora R. Funding: Canadian Institutes of Health Research (CIHR): Project Scheme Funds Awarded: $631,000 Years: 3
June 2017 Heparin anticoagulation to improve outcomes in septic shock: The HALO International Phase II efficacy RCT Principal Investigators: Ryan Zarychanski Co Applicants: Alejandria M, Kumar A, Houston DS Collaborators: Fergusson DA, Ramsay T, Marshall JC Funding: Cancercare Manitoba Foundation Funds Awarded: $120,000 Years: 2
Ryan Zarychanski
June 2017 REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU Principal Investigator: Gordon Guyatt Co Applicants: Alhazzani W, Alshahrani M, Ball I, Barletta J, Cartin-Ceba R, Charbonney E, Chau L, Cook D, Deane A, Dodek P, Duan E, English S, Finfer S, Freitag A, Goffi A, Golan E, Hall R, Herridge M, Johnson D, Kanji S, Karachi T, Lamontagne F, Lauzier F, Loubani O, Marshall J, Menta S, Muscedere J, Myburgh J, Oeckler R, Ovakin D, Reeve B, Reynolds S, Rochwerg B, Roussos M, Smith O, Surette M, Thabane L, Tsang J, Wiliamson D, Wood G, Xie F, Zarychanski R, D Chong, M Ostermann Funding: Canadian Institutes of Health Research: Project Grant Funds Awarded: $1,935,832 Years: 3
June 2017 Aneurysmal subarachnoid hemorrhage - red blood cell transfusion and outcome: a randomized controlled trial Principal Investigator: Shane English Co Applicants: Acker J, Algird A, Al Thenayan E, Boyd J, Chapman M, Chasse M, D’aragon F, DeCosta L, Dowlatshahi D, Fergusson DA, Griesdale D, Kramer A, Kutsogiannis J, Lauzier F, Lum C, Marshall S, McIntyre L, Pagliarello G, Scales D, Sinclair J, Singh J, Tinmouth A, Turgeon AF, Zarychanski R, Butcher K, Funding: Canadian Institutes of Health Research: Project Grant Funds Awarded: $1,385,000 Years: 5
June 2017 Critical Care Outcomes in Hematology Malignancy and Stem Cell Transplant Principal Investigators: Laveena Munshi and Sangeeta Mehta Co Applicants: Bagshaw S, Burry L, Cheung M, Daly A, Detsky M, Earl C, Fergusson DA, Green R, Griesdale D, Herridge M, Lapinsky S, Magder S, Minden M, Patel R, Qureshi S, Rochwerg B, Scales D, Schimmer, Wang HT, Zarychanski R. Funding: Leukemia and Lymphoma Society of Canada Funds Awarded: $199,742 Years: 2
December 2016 Project title: Interventions and Policies Influencing Primary Healthcare Professionals Managing Chronic Diseases: An Evidence Synthesis Principal Investigators: Bhupendrasinh Chauhan (nominated), Ryan Zarychanski, Jeanette Edwards Co-applicants: Terry Klassen, Kathryn Sibley, Beverley Temple, Alexander Singer, Gayle Halas, Carolyn Shimmin Collaborators: Kristin Anderson, Colleen Metge Knowledge users: Tamara Buchel, Kelsey Kevinsen Partners: Manitoba Health, Seniors and Active Living, Province of Manitoba; College of Pharmacy, University of Manitoba; Saskatoon Health Research Ryan Zarychanski
Foundation and George and Fay Yee Centre for Healthcare Innovation, The SPOR SUPPORT Unit, Manitoba. Other jurisdictions: Saskatchewan: Thomas Rotter, Donna Goodridge. Newfoundland: Julia Lukewich, Alice Gaudine, Shabnam Asghari Funding agency: Canadian Institutes of Health Research (CIHR) Total Funds Awarded: $50,468 (CIHR: $25,000 and Partners: $25,468) Duration: 1 year
March 2016 Transfusion in traumatic brain injury (TSiTBI Trial) Principal Investigators: Alexis F Turgeon, Dean Fergusson, Francois Lauzier Co-investigators: Algird A, Baker A, Ball I, Burns K, Charbonney E, Chassé M, English S, Green R, Griesdale D, Kramer A, Lamontagne F, Laroche V, Moore L, Scales D, Shahin J, St. Onge M, Tinmouth A, Zarychanski R, Zygun D Knowledge users: Clement J, Delage G, Fox-Robichaud A, Hébert P, Oleary S, Riopelle R, Trainee: Lessard Bonaventure P Collaborator: Meade M Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $1,390,105 Duration: 5 years
March 2016 The Lyonel G. Israels Professorship in Hematology Principal Investigator: Dr. Ryan Zarychanski Endowed Chair (3,000,000) Funds available: ~$120,000/year for research program support Years: 5
June 2016 Heparin anticoagulation to improve outcomes in septic shock: The HALO International Phase II efficacy RCT Principal Investigators: Ryan Zarychanski and Marissa Alejandria Co Investigators: Anand Kumar, Yvette Barez, Dean Fergusson, Deborah Cook, John Marshall, Fox-Robichaud, McIntyre LA, Ramsay T, Turgeon AF Funding: Philippine Council for Health Research & Development (PCHRD) Funds Awarded: $132,000 Years: 3
January 2016 Grant Title: Canadian Traumatic Brain Injury Research Consortium (CTRC) Principle Investigators: James Hutchison, (co-lead); Alexis F Turgeon (co- Lead); Carolyn A Emery; Isabelle Gagnon; Cheryl Wellington; Richard J Riopelle (Principal Knowledge User) Co Investigators: Archambault P; Baker AJ; Barlow KM; Bayley MT; Beauchamp MH; Chapman MG; Chasse M; Clarke DB; Colantonio A; Cusimano MD; Emeriaud G; English SW; Esser MJ; Fraser DD; Griesdale D; Guerguerian A; Lacroix J; Lauzier F; Marshall SC; McCredie VA; Mcfadyen Ryan Zarychanski
BJ; Panenka WJ; Ptito A; Reed N; Winston BW; Yeates KO; Zarychanski R; Zemek R; Zygun DA; Fox-Robichaud A (Knowledge User) Collaborators: Babul S; Brubacher J; Cullen N; De Beaumont L; de Guise E; De Matteo C; Gélinas C; Gosselin N; Green Robert; Green Robin; Kramer A; Kutsogiannis J; Lamontagne M; Levine B; Marcoux J; McKerral M; Moore L; Ouellet MC; Rizoli S; Rowe B; Scales D; Schachar R, Schneider K; Sutherland G; Swaine B; Tator CH; Teasell R; Wang YT; Van DonKelaar P; Wheeler A. Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $1,824,513 Years: 5 (December 1st, 2015 to November 30, 2019)
July 2015 CanVECTOR (Canadian Venous Thromboembolism Clinical Trials and Outcomes Research) Network Principal Investigators: Marc Rodger & Susan Kahn Co Applicants: Afilalo M; Anderson D; Bates S; Blostein M; Carrier M; Castellucci L; Chagnon I; Chitsike R; Conway E; Crowther M; de Wit K; Demers C; Dolan S; Douketis J; Duffett L; Emed J; Fergusson D; Gandara E; Geerts W; Ginsberg J; Gonsalves C; Grad R; Gross P; Guindon G; Haynes R; Hirsch A; Iorio A; Kassis J; Kearon C; Kovacs MJ; Lang ES; Lazo-Langner A; Le Gal G; Lee AY; Levinson AJ; Levy AR; Liaw PC; Lim W; Linkins L; Louzada MD; McLeod AG; Moodley U; Pai M; Pluye P; Ramsay TO; Ray JG; Roussin A; Routhier N; Schulman S; Selby R; Shivakumar SP; Siegal DM; Smith RE; Solymoss S; Tagalakis V; Takach Lapner S; Thavorn K; Weitz JI; Wells PS; Wu CM; Zarychanski R Funding: Canadian Institute of Health Research (CIHR), Community Development Program Grants Funds Awarded: $1,500,000 Years: 5
July 2015 Tranexamic Acid during Cystectomy Trial (TACT) Principal Investigators: Rodney H. Breau, Ilias Cagiannos, Franco Momoli. Co Applicants: Bryson G, Cameron C, Fergusson DA, Fradet V, Kanji S, Knoll G, Morash C, Turgeon A, Zarychanski R. Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $394,050 Years: 3
March 2014 Transfusion of Plasma Prior to Invasive Procedures Pilot Trial Principal Investigators: Dr. Alan Tinmouth and Dean Fergusson Co Applicants: Zarychanski R, Chasse M, Laroche V, McIntyre L, Turgeon AF Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $317,274 Years: 2.5 Ryan Zarychanski
June 2014 Bleeding, transfusion, and the use of anticoagulants in patients with critical illness: Generating evidence to inform practice change and improve clinical outcomes Principal Investigator: Dr. Ryan Zarychanski Funding: Canadian Institute of Health Research (CIHR) New Investigator Award Funds Awarded: $300,000 (SALARY AWARD) Years: 5
March 2014 Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease Principal Applicant: Dr. Ruth Ann Marrie Co Applicants: Bernstein CN, Bolton J, Graff L, Walker J, Sareen J, Zarychanski R, Katz A, Blanchard J, Frisk J, Berrigan L, Patten S, Ghaffar, Lix L, Hitchon C Funding: Canadian Institutes of Health Research (CIHR) Funds Awarded: $2,500,000 Years: 5
February 2014 The George and Fay Yee Centre for Healthcare Innovation Program: Support for People and Patient-Oriented Research and Trials (SUPPORT) Units Principal Applicant: Dr. Terry Klassen Co Applicants: Zarychanski R, Wittmeier K, Bohm E, Krupka F, Lix L, Abou-setta AM, Mamoud S, Jiang D, Hinrichsen A Collaborators: Martens P, Moses S, Woodgate R, Dean H, Van de Mosselaer G, Anderson-De Coteau M, Weise C, Vielfaure-Mackenzie M, Barnard D Funds Awarded: $29,682,742 Funding partners: Canadian Institutes of Health Research (CIHR) $11,232,049 Manitoba Health $5,000,000 The Winnipeg Regional Health Authority (WRHA) $16,884,582 University of Manitoba $7,798,160 Years: 5
November 2013 Effect of unfractionated heparin on cell free DNA and fibrinolysis in Septic Shock – HALO translational analysis Principal Applicant: Dr. Ryan Zarychanski Funding: Bayer Funds Awarded: $50,000 Years: 1
June 2013 Mechanisms of inflammation and thrombosis in septic shock: Heparin anticoagulation to improve outcomes in septic shock: - Translational Analyses Principal Applicant: Dr. Ryan Zarychanski Co Applicants: Liaw P, Banerji V, Fox-Robichaud A Ryan Zarychanski
Funding: CancerCare Manitoba Foundation Funds Awarded: $58,000 Years: 2
March 2012 Heparin anticoagulation to improve outcomes in septic shock: The HALO Pilot Principal Investigators: Dr. Ryan Zarychanski and Dean Fergusson Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hébert PC, Houston DS, Kanji S, Kumar A, Liaw P, Marshall J, McIntyre L, Ramsay T, Tinmouth A, Turgeon AF Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $288,152 Years: 2
March 2012 Early determination of long-term prognosis in critically ill patients with severe traumatic brain injury (TBI-Prognosis multi-centre prospective study) Principal Investigator: Alexis F Turgeon Co Applicants: Bagshaw S, Bernard F, Burns K, Fergusson D, Green R, Griesdale D, Kutsogiannis J, Lamontagne F, Lauzier F, Martin C, McIntyre L, Meade M, Moore L, Moulin V, Pagliarello G, Reynolds S, Rigamonti A, Savard M, Scales D, Zarychanski R, Zygun D. Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $1,141,067 Years: 3
March 2012 Tranexamic Acid in Cystectomy Trial (TACT) pilot study Principal Investigators: Rodney H. Breau, Ilias Cagiannos, Franco Momoli. Co Applicants: Bryson G, Kanji S, Morash C, Turgeon A, Zarychanski R. Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $244,275 Years: 1
March 2011 Heparin anticoagulation to reduce death in septic shock: HADES Pilot Principal Investigators: Ryan Zarychanski and Dean Fergusson Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hébert PC, Houston DS, Kanji S, Kumar A, Marshall J, McIntyre L, Ramsay T, Tinmouth A, Turgeon AF Collaborators: Liaw P Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $100,000 Years: 2 years
March 2011 Heparin anticoagulation to reduce death in septic shock: HADES Pilot Principal Investigators: Ryan Zarychanski and Dean Fergusson Ryan Zarychanski
Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hébert PC, Houston DS, Kanji S, Kumar A, Marshall J, McIntyre L, Ramsay T, Tinmouth A, Turgeon AF Collaborators: Liaw P Funding: Manitoba Health Research Council (MHRC) Funds Awarded: $100,000 Years: 2 years
June 2011 Screening for occult malignancy in patients with unprovoked venous thromboembolism: a randomized controlled trial using a comprehensive computed tomography of the abdomen/pelvis (SOME trial) Principal Investigator: Marc Carrier Co-Applicants: Zarychanski R, Coyle D, Ramsay T, Tao H, Lazo-Langner A, Rogder M, Wells P, Le Gal G, Taglakis V, Funding: Heart and Stroke Foundation of Canada Funds Awarded: $202,590 Years: 3 years
December 2010 Phenotypic and genotypic evaluation of a family cohort with haemolytic anaemia Principal Investigator: Ryan Zarychanski Co-Applicants: Houston BL, Houston DS, Israels S Funding: Manitoba Medical Services Foundation Funds Awarded: $20,000 Years: 1 year
July 2010 CIHR Randomized Controlled Trials: Mentoring Award Principal Investigator: Ryan Zarychanski Mentor: Fergusson DA Co-mentors: Bernstein CN, Houston DS, Cook DJ Funding: Canadian Institute of Health Research (CIHR) Funds awarded: $160,000 (SALARY AWARD) Years: 2 years
July 2010 Weaning and Variability Evaluation (WAVE) Principal Investigator: Andrew Seely Co-Applicants: Zarychanski R, Fergusson DA, Ferguson N, Lellouche F Marshal J, Maziak DE, McIntyre LA, Ramsay TO, Rubenfeld G, Scales DC Funding: Canadian Institutes of Health Research (CIHR), Operating Grant Funds awarded: $544,134 Years: 3 years
July 2010 Epidemiology of Thromboembolism in Critical Care (EPITEC) Principal Investigator: Deborah J Cook Ryan Zarychanski
Co-Applicants: Zarychanski R, Crowther M, Fowler R, Jacka M, Meade M, Turgeon A, Devereaux P, Hall R, Lauzier F, Mehta S, Dodek P, Herridge M, Marshall J, Muscedere J Funding: Canadian Institutes of Health Research (CIHR), Operating Grant Funds Awarded: $63,899 Duration: 1 year
September 2009 Plasma Utilization in Cardiac Surgery (PUCS): A Multicentre Observational Study Principal Investigator: Dr. Alan Tinmouth Co-Applicants: Zarychanski R, Fergusson DA, Hébert P, Fraser R Shehata N, Webert K Funding: Canadian Institutes of Health Research, Operating Grant Funds awarded: $206,885 Duration: 1 year
January 2009 Research Support / New Faculty Start up Funding Funding Source: CancerCare Manitoba Principal Investigator: Ryan Zarychanski Funding awarded: $225,000 Duration: 3 years
July 2006 Canadian Blood Services Research Fellowship Principal Investigator: Ryan Zarychanski Funding Source: Canadian Blood Services Funding Awarded: $142,000 (SALARY AWARD) Duration: 2 years Ryan Zarychanski
PUBLICATIONS (JOURNAL ARTICLES)
**ALL CAPS denotes research supervisor to trainees
Accepted or in Press
Kashani HH, Lodeewyks C, Kavosh MS, Jeyaraman MM, Neilson C, Okoli G, Rabbani R, Abou- Setta AM, Zarychanski R, Grocott HP. Restrictive versus liberal transfusion strategies in cardiac surgery: a systematic review and meta-analysis with trial sequential analysis. Canadian Journal of Anesthesia. 2019.
HOUSTON BL, Uminski K, Mutter T, Rimmer E, Houston DS, Menard CE, Garland A, Ariano R, Tinmouth A, Abou-Setta AM, Rabbani R, Neilson C, Rochwerg B, Turgeon AF, Falk J, Breau R, Fergusson DA, Zarychanski R. Efficacy and safety of tranexamic acid in major non-cardiac surgeries at high risk of transfusion: a systematic review and meta-analysis. Transfusion Medicine Reviews. 2019.
HOUSTON BL, Rimmer E, Zarychanski R, Seftel M. Laboratory testing in the evaluation of a monoclonal protein: a practical framework for interpretation. South African Medical Journal. 2019. [Review].
MENARD CM, Seftel M, Ponnampalam A, Zarychanski R (senior author/supervisor). When to transfuse? Red blood cell and platelet transfusion thresholds in clinical practice. South African Medical Journal. 2019. [Review].
Turgeon AF, Zarychanski R, Francoeur CL, Lauzier F. Cardiac Donation after Circulatory Death: The Heart of the Matter. Canadian Journal of Anesthesia. 2019.
Ryan Zarychanski
Submitted/Under Review
Verret M, Lauzier F, Zarychanski R, Savard X, Perron C, Pinard AM, Leblanc G, Cossi MJ, Turgeon AF, on behalf of the Canadian Perioperative Anesthesia Clinical Trials Group (PACT). Perioperative use of Gabapentinoids for the management of postoperative acute pain: A systematic review and meta-analysis. Anesthesia and Analgesia. 2019.
MOONEY O, Bell D, Turgeon AF, Kumar A, Rimmer E, Houston DS, Zarychanski R (senior author/supervisor). Nucleated red blood cells as an independent predictor of ICU mortality and ICU recidivism. Intensive Care Medicine. 2017
Oberoi S, Yang J, Woodgate RL, Niraula S, Banerji S, Israels SJ, Altman G, Beattie S, Rabbani R, Askin N, Gupta A, Sung L, Abou-Setta AM, Zarychanski R (senior author/supervisor). Mindfulness based interventions to reduce anxiety in adults and children with cancer: A systematic review and meta-analysis. Critical Reviews in Oncology/Hematology. 2019.
Liu S, Skidmore B, Rabbani R, Zarychanski R, Abou-Setta AM, Toleva O. Ischemic post- conditioning for ST-elevation myocardial infarction treated with primary percutaneous coronary intervention: A systematic review and meta-analysis. Canadian Journal of Cardiology. 2019.
Akinrolie O, Barclay R, Strachan S, Gupta A, Jasper US, Jumbo SU, Askin N, Rabbani R, Zarychanski R, Abou-Setta AM. Motivational interviewing and physical activity among older adults: A systematic review and meta-analysis. American Journal of Health Promotion. 2019.
Fergusson DA, Chassé1 M, Kokolo M, Aaron S, McIntyre L, Hiremath S, Zarychanski R, Turgeon AF, Alvarez G, Beck A, Monsour D, Ducharme R, Grant-Orser A, Kimmelman J, Knoll G. The use of clinically important outcomes in clinical trials assessing effectiveness: a systematic review. Journal for the Society of Clinical Trials. 2017
English SW, Saigle V, McIntyre L, Chassé M, Fergusson DA, Turgeon AF, Lauzier F, Griesdale D, Garland A, Zarychanski R, Algird A, van Walraven C. Multi-centre validation of the Ottawa SAH prediction models using health administrative data. Neurology. 2019
Ryan Zarychanski
Published
138. Matthewson G, Kooner S, Rabbani R, Gottschalk T, Old J, Abou-Setta AM, Zarychanski R, Leiter J, MacDonald P. Does a Delay in Anterior Cruciate Ligament Reconstruction Increase the Incidence of Secondary Pathology in the Knee? A Systematic Review and Meta-Analysis. Clinical Journal of Sport Medicine. 2019; [Epub ahead of print]. DOI: 10.1097/JSM.0000000000000762. PMID: 31743219.
137. Lim S, Hammond S, Park J, Hochman D, Ma M, Rabbani R, Abou-Setta AM, Zarychanski R (senior author/supervisor). Training Interventions to Improve Adenoma Detection Rates During Colonoscopy: A Systematic Review and Meta-Analysis. Surgical Endoscopy. 2019 Oct 8. doi: 10.1007/s00464-019-07153-7. [Epub ahead of print] PubMed PMID: 31595401.
136. Alaifan T, Alenazy A, Xiang Wang D, Fernando S, Spence J, Belley-Cote E, Fox-Robichaud A, Ainsworth C, Karachi T, Kyeremanteng K, Zarychanski R, Whitlock R, Rochwerg B. Tranexamic Acid in Cardiac Surgery: a systematic review and meta-analysis (protocol). BMJ Open. 2019;9(9):e028585. doi:10.1136/bmjopen-2018-028585. PMID: 31530593.
135. Turgeon AF, Dorrance K, Archambault P, Lauzier F, Lamontagne F, Zarychanski R, Fowler R, Moore L, Lacroix J, English S, Boutin A, Muscedere J, Burns KEA, Griesdale D, McIntyre LA, Scales D, Bernard F, Yamada J, Squires JE; Canadian Traumatic Brain Injury Research Consortium and the Canadian Critical Care Trials Group. Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury. Canadian Medical Association Journal (CMAJ). 2019 Jun 17;191(24):E652-E663. doi: 10.1503/cmaj.190154. PMID: 31209132
134. Bonaventure PL, Lauzier F, Zarychanski R, Boutin A, Shemilt M, Saxena M, Zolfagari P, Griesdale D, Menon D, Stanworth S, English S, Chassé M, Fergusson DA, Moore L, Kramer A, Robitaille A, Myburgh J, Hutchinson P, Cooper J, Turgeon AF. Red Blood Cell Transfusion in Critically ill Patients with Traumatic Brain Injury: An International Survey of Physicians' Attitudes. Canadian Journal of Anesthesia. 2019. Canadian Journal of Anesthesia. 2019 Apr 22. doi: 10.1007/s12630-019-01369-w. PMID: 31012052
133. Shemilt M, Boutin A, Lauzier F, Zarychanski R, Moore L, McIntyre LA, Nadeau L, Fergusson DA, Mercier E, Archambault P, Lamontagne F, Perron C, Léger C, Turgeon AF. Prognostic value of glial fibrillary acidic protein in patients with moderate and severe traumatic brain injury: a systematic review and meta-analysis. Critical Care Medicine. 2019 Jun;47(6):e522-e529. doi: 10.1097/CCM.0000000000003728. PMID: 30889029
132. Mortaza N, Abou-Setta AM, Zarychanski R, Loewen H, Rabbani R, Glazebrook CM. Upper Limb Tendon/Muscle Vibration in Persons with Chronic Stroke: A Systematic Review and Meta- analysis. European Journal of Physical and Rehabilitation Medicine. 2019 Mar 11. doi: 10.23736/S1973-9087.19.05605-3. [Epub ahead of print]. PMID: 30868835
131. Zawaly K, Rumbolt C, Abou-Setta AM, Neilson C, Rabbani R, Zarychanski R, Singh H. The efficacy of split-dose bowel preparations for polyp detection: a systematic review and meta-analysis. Ryan Zarychanski
American Journal of Gastroenterology. 2019. Mar 11. doi: 10.14309/ajg.0000000000000155. PMID: 30865011
130. MENARD CE, Kumar A, Houston DS, Turgeon AF, Rimmer E, Houston BL, Doucette S, Zarychanski R (senior author/supervisor). Evolution and impact of thrombocytopenia in septic shock: a retrospective cohort study. Critical Care Medicine. 2019. Apr;47(4):558-565. doi: 10.1097/CCM.0000000000003644. PMID: 30855327
129. Ruel-Laliberté J, Lessard-Bonaventure P, Fergusson D, Lacroix J, Zarychanski R, Lauzier F, Tinmouth A, Hebért PC, Green R, Griesdale D, Fowler R, Kramer A, McIntyre L, Zygun D, Walsh T, Stanworth S, Capellier G, Pili-Floury S, Samain E, Clayton L, Marshall J, Pagliarello J, Sabri E, Neveu X, Léger C, Turgeon AF. Effect of age of transfused red blood cells on neurological outcome following traumatic brain injury (ABLE-tbi Study). Canadian Journal of Anesthesia. 2019. Jun;66(6):696-705. doi: 10.1007/s12630-019-01326-7. Epub 2019 Feb 26. PMID: 30809776
128. Walkty A, Karlowsky J, Zarychanski R, Kadkhoda K, Lagace-Wiens P. Marked elevation of serum ferritin associated with Anaplasma phagocytophilum infection. Journal of the Association of Medical Microbiology. 2019 Jan 4(1):38-41 doi.org/10.3138/jammi.2018-0033
127. Jeyaraman MM, Abou-Setta AM, Grant L, Farshidfar F, Copstein L, Lys J, Gottschalk T, Desautels D, Czaykowski P, Pitz M, Zarychanski R (senior author/supervisor). Dairy product consumption and development of cancer: An overview of reviews. BMJ Open. 2019 Jan 25;9(1):e023625. doi: 10.1136/bmjopen-2018-023625. PMID: 30782711
126. Arabi YM, Al-Hameed F, Burns KEA, Mehta S, Alsolamy SJ, Alshahrani MS, Mandourah Y, Almekhlafi GA, Almaani M, Al Bshabshe A, Finfer S, Arshad Z, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Lababidi H, Al Aithan A, Abdukahil SAI, Jose J, Afesh LY, Al-Dawood A; Saudi Critical Care Trials Group. Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis. (Collaborator). N Engl J Med. 2019 Apr 4;380(14):1305-1315. doi: 10.1056/NEJMoa1816150. Epub 2019 Feb 18. PMID: 30779530
125. Okoli G, Rabbani R, Kashani HH, Wierzbowski AK, Neilson C, Mansouri B, Zarychanski R, Abou-Setta AM. Vitamin and mineral supplements for migraine prophylaxis: A systematic review and meta-analysis of randomized controlled trials. The Canadian Journal of Neurological Sciences. Mar;46(2):224-233. doi: 10.1017/cjn.2018.394. Epub 2019 Feb 15. PMID: 30764890
124. Abou-Setta AM, Rabbani R, Lix L, Turgeon AF, Houston BL, Fergusson DA, Zarychanski R. Can author bias be detected in meta-analysis? Canadian Journal of Anesthesia. 2019 Mar;66(3):287- 292. doi: 10.1007/s12630-018-01268-6. Epub 2019 Feb 6. PMID:30725345
123. Verret M, Lauzier F, Zarychanski R, Savard X, Cossi MJ, Pinard AM, Leblanc G, Turgeon AF. Perioperative use of gabapentinoids for the management of postoperative pain: protocol of a systematic review and meta-analysis. Systematic Reviews. 2019 Jan 16;8(1):24. doi: 10.1186/s13643- 018-0906-3. PMID: 30651123
122. Whitehouse CE, Fisk JD, Bernstein CN, Berrigan LI, Bolton JM, Graff LA, Hitchon CA, Marriott JJ, Peschken CA, Sareen J, Walker JR, Stewart SH, Marrie RA; CIHR Team in Defining Ryan Zarychanski
the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease. Collaborators: Katz A, Lix LM, Patten SB, Singer A, El-Gabalawy R, Zarychanski R. Comorbid anxiety, depression, and cognition in MS and other immune-mediated disorders. Neurology. 2019 Jan 11. doi: 10.1212/WNL.0000000000006854. [Epub ahead of print]. PMID: 30635487
121. UMINSKI K, Kadkhoda K, Houston BL, Lopez A, McKenzie L, Lindsay R, Walkty A, Embil J, Zarychanski R (senior author/supervisor). Anaplasmosis: an emerging tick-born disease of importance in Canada. ID Cases. 2018 Nov 28;14:e00472. doi: 10.1016/j.idcr.2018.e00472. eCollection 2018. PMID: 30524954
120. Zarychanski R, Turgeon AFT. Re-framing the question: Should hydroxyethyl starch be used in clinical practice? Canadian Journal of Anesthesia. 2018. Nov 7. doi: 10.1007/s12630-018-1246-4. [Epub ahead of print] [Editorial]. PMID: 30406388
119. English SW, McIntyre L, Saigle V, Chassé M, Fergusson D, Turgeon AF, Lauzier F, Griesdale D, Garland A, Zarychanski R, Algird A, van Walraven C. The Ottawa SAH Search Algorithm: Protocol for A Multi-Centre Study to Validate a Novel and Innovative Primary SubArachnoid Hemorrhage Prediction Model using Health Administrative Data (The SAHepi Prediction Study Protocol). BMC Medical Research Methodology. 2018 Sep 15;18(1):94. doi: 10.1186/s12874-018- 0553-3. PMID: 30219029
118. LODEWYKS C, Heinrichs J, Grocott H, Karkouti K, Romund G, Arora R, Tangri N, Rabbani R, Abou-Setta AM, Zarychanski R (senior author/supervisor). Point of care viscoelastic hemostatic testing in cardiac surgery: A systematic review and meta-analysis. Canadian Journal of Anesthesia. 2018 Dec;65(12):1333-1347. doi: 10.1007/s12630-018-1217-9. PMID: 30194674
117. Kumar A, Zarychanski R, Pisipati A, Kumar A, Kethireddy S, Bow EJ. Fungicidal versus fungistatic therapy of invasive Candida infection in non-neutropenic adults: a meta-analysis. Mycology. 2018 Jan 9;9(2):116-128. doi: 10.1080/21501203.2017.1421592. PMID: 30123667
116. Kredentser MS, Blouw M, Marten N, Sareen J, Bienvenu OJ, Ryu J, Beatie B, Logsetty S, Graff LA, Eggertson S, Sweatman S, Debroni B, Cianflone N, Arora R, Zarychanski R, Olafson K. Preventing posttraumatic stress in ICU survivors: A single-center pilot randomized controlled trial of ICU diaries and psychoeducation. Critical Care Medicine. 2018 Dec;46(12):1914-1922. doi: 10.1097/CCM.0000000000003367. PMID: 30119073
115. Farooqui MA, Elsayed Y, Jeyaraman MM, Dingwall O, Tagin M, Zarychanski R, Rabbani R, Abou-Setta AM. Pre-symptomatic targeted treatment of patent ductus arteriosus in preterm newborns: A systematic review and meta-analysis. Journal of Neonatal-Perinatal Medicine. 2018 Jul 19. doi: 10.3233/NPM-17130. [Epub ahead of print]. PMID: 30040749
114. English SW, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Garland A, Fergusson DA, Zarychanski R, van Walraven C, Montroy K, Ziegler J, Dupont-Chouinard R, Carignan R, Dhaliwal A, Mallick R, Sinclair J, Boutin A, Pagliarello G, Tinmouth A, McIntyre L. Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid Ryan Zarychanski
hemorrhage – Results of a multi-center cohort study. Critical Care. 2018;Jul 4;22(1):169. doi: 10.1186/s13054-018-2089-7. PMID: 29973245
113. Gerges PRA, Moore L, Léger C, Lauzier F, Shemilt M, Zarychanski R, Scales D, Burns KEA, Bernard F, Zygun D, Neveu X, Turgeon AF; Canadian Critical Care Trials Group. Intensity of care and withdrawal of life-sustaining therapies in severe traumatic brain injury patients: A post-hoc analysis of a multicenter cohort study. Canadian Journal of Anesthesia. 2018; Sep;65(9):996-1003. doi: 10.1007/s12630-018-1171-6. Epub 2018 Jun 14. PMID: 29949093
112. Leblanc G, Boutin A, Shemilt M, Lauzier F, Moore L, Potvin V, Zarychanski R, Archambault P, Lamontagne F, Léger C, Turgeon AF. Incidence and impact of withdrawal of life-sustaining therapies in clinical trials of severe traumatic brain injury: a systematic review of randomized controlled trials. Clinical Trials. 2018 Aug;15(4):398-412. doi: 10.1177/1740774518771233. Epub 2018 Jun 4. PMID: 29865897
111. Breau RH, Lavallée LT, Cnossen S, Witiuk K, Cagiannos I, Momoli F, Bryson G, Kanji S, Morash C, Turgeon A, Zarychanski R, Mallick R, Knoll G, Fergusson DA. Tranexamic Acid versus Placebo to Prevent Blood Transfusion during Radical Cystectomy for Bladder Cancer (TACT): Study Protocol for a Randomized Controlled Trial. Trials. 2018 May 2;19(1):261. doi: 10.1186/s13063-018-2626-3. PMID: 29716640
110. Delara M, Chauhan B, Le ML, Abou-Setta AM, Zarychanski R, tJong GW. Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: A systematic review and meta-analysis. Archives of Disease in Childhood. 2018 Apr 17. pii: fetalneonatal-2017-314046. doi: 10.1136/archdischild-2017-314046. [Epub ahead of print] PMID: 29666203
109. HOUSTON BL, Hurrie D, Graham J, Perija B, Rimmer E, Abou-Setta AM, Bernstein CN, Houston DS, Zarychanski R. (senior author/supervisor). Efficacy of iron replacement therapy on fatigue and work capacity in non-anemic adults with iron depletion: a systematic review of randomized controlled trials. British Medical Journal Open. 2018 Apr 5;8(4):e019240. doi:10.1136/ bmjopen-2017-019240. PMID: 29626044
108. Singal D, Menard C, Neilson CJ, Brownell M, Hanlon-Dearmnan A, Chudley A, Zarychanski R, Abou-Setta AM. The effectiveness of evidence-based treatments of fetal alcohol spectrum disorders in children and adolescents: A systematic review protocol. BMJ Open. 2018;Mar 9;8(3):e013775. doi: 10.1136/bmjopen-2016-013775. PMID: 29525767
107. Boutin A, Moore L, Green RS, Zarychanski R, Erdogan M, Lauzier F, English S, Fergusson DA, Butler M, McIntyre LA, Chasse M, Lessard-Bonaventure P, Léger C, Desjardins P, Griesdale D, Lacroix J, Turgeon AF. Hemoglobin thresholds and red blood cell transfusion in adult patients with moderate or severe traumatic brain injuries: a retrospective cohort study. Journal of Critical Care. 2018; Jun;45:133-139. doi: 10.1016/j.jcrc.2018.01.023. Epub 2018 Jan 31. PMID: 29459342
106. Jeyaraman MM, Qadar SMZ, Wierzbowski AK, Farshidfar F, Lys J, Dickson G, Grimes K, Parker J, Phillips L, Mitchell J, Leith E, Phillips K, Betty W, Becker L, McCarthy N, Johnson D, Ryan Zarychanski
Krupka F, Zarychanski R, Abou-Setta AM. Effective approaches to determining return on investment in healthcare leadership development programs: a systematic scoping review. Leadership in Health Services. 2018 Feb 5;31(1):77-97. doi: 10.1108/LHS-02-2017-0005. Epub 2017 Nov 15. PMID: 29412095
105. Marrie RA, Graff L, Walker J, Fisk JD, Patten SB, Hitchon CA, Lix LM, Bolton JM, Sareen L, Katz A, Berrigan LI, Marriott JJ, Singer A, El-Gabalawy R, Zarychanski R, Bernstein CN. A prospective study of the effects of psychiatric comorbidity in immune-mediated inflammatory disease: rationale, protocol and participation. JMIR Research Protocols. 2018 Jan 17;7(1):e15. doi: 10.2196/resprot.8794. PMID: 29343461
104. Zarychanski R, Houston DS. Assessing Thrombocytopenia in the Intensive Care Unit: The Past, Present, and Future. Hematology Am Soc Hematol Educ Program. 2017. Dec 8;2017(1):660- 666. doi: 10.1182/asheducation-2017.1.660. PMID: 29222318
103. Jeyaraman MM, Rabbani R, Copstein L, Sulaiman W, Farshidfar F, Kashani H, Qadar SMZ, Guan Q, Skidmore B, Dias S, Kardami E, Ducas J, Mansour S, Zarychanski R, Abou-Setta AM. Autologous Bone Marrow Stem Cell Therapy in Patients with ST-elevation Myocardial Infarction: A Systematic Review and Meta-analysis. Canadian Journal of Cardiology. 2017. Dec;33(12):1611- 1623. doi: 10.1016/j.cjca.2017.10.001. PMID: 29173601
102. Jung J, Pinto R, Zarychanski R, Cook DJ, Jouvet P, Marshall JC, Kumar A, Long J, Rodin R, Fowler R on behalf of the ICU-Flu Investigators and the Canadian Critical Care Trials Group. 2009- 2010 H1N1-related critical illness among Aboriginal and non-Aboriginal Canadians. PloS One. 2017;Oct 19;12(10):e0184013. doi: 10.1371/journal.pone.0184013. PMID: 29049285
101. LEEIES M, Flynn E, Turgeon AF, Paunovic B, Loewen H, Rabbani R, Abou-Setta AM, Ferguson N, Zarychanski R (senior author/supervisor). High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: A systematic review and meta-analysis. Systematic Reviews. 2017;6:202. DOI 10.1186/s13643-017-0593-5. PMID: 29037221
100. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Shemilt M, Moore L, Zarychanski R, Douville V, Fergusson DA, Turgeon AF. The Prognostic Value of Magnetic Resonance Imaging in Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Critical Care Medicine. 2017 Dec;45(12):e1280-e1288. doi: 10.1097/CCM.0000000000002731. PMID: 29028764
99. Arnold DM, Lauzier F, Albert M, Williamson D, Li N, Zarychanski R, Doig C, McIntyre L, Freitag A, Crowther M, Saunders L, Clarke F, Cooper J, Qushmaq I, Lopes RD, Heels-Ansdell D, Webert K and Cook DJ, For the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. The Association Between Platelet Transfusions and Bleeding in Critically Ill Patients with Thrombocytopenia. Research and Practice in Thrombosis and Haemostasis. 2017;1:103–111. doi.org/10.1002/rth2.12004. PMID: 30046678
98. BEDNARCZYK JM, Fridfinnson JA, Kumar A, Blanchard L, Rabbani R, Bell D, Funk D, Turgeon AF, Abou-Setta AM, Zarychanski R. Incorporating dynamic assessment of fluid Ryan Zarychanski
responsiveness into goal-directed therapy: A systematic review and meta-analysis. Critical Care Medicine. 2017. Sep;45(9):1538-1545. doi: 10.1097/CCM.0000000000002554. PMID: 28817481
97. Azad MB, Abou-Setta AM, Chauhan BF, Pharm M, Rabbani R, Lys J, Copstein L, Mann A, Jeyaraman MM, Derksen AE, Fiander M, MacKay DS, McGavock J, Wicklow B, Zarychanski R (senior author/supervisor). Non-nutritive sweeteners and cardio-metabolic health: A systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Canadian Medical Association Journal. 2017 Jul 17;189(28):E929-E939. doi: 10.1503/cmaj.161390. PMID: 28716847
96. Azad MB, MacKay DS, Zarychanski R. Response to: The importance of study design in the assessment of non-nutritive sweeteners and cardiometabolic health. Canadian Medical Association Journal. 2017 Nov 20;189(46):E1426. doi: 10.1503/cmaj.733441. PMID: 29158458
95. Wilkinson K, Wei Y, Szwajcer A, Rabbani R, Zarychanski R, Abou-Setta AM, Mahmud SM. Efficacy and safety of high-dose influenza vaccine in elderly adults: A systematic review and meta- analysis. Vaccine. 2017 May 15;35(21):2775-2780. doi: 10.1016/j.vaccine.2017.03.092. PMID: 28431815
94. Turgeon AF, Lauzier F, Zarychanski R, Fergusson DA, Léger C, McIntyre LA, Bernard F, Rigamonti A, Burns K, Griesdale D, Green R, Scales DC, Meade MO, Savard M, Shemilt M, Paquet J, Gariépy JL, Lavoie A, Reddy K, Jichici D, Pagliarello G, Zygun D, Moore L, for the TBI- Prognosis study team and the Canadian Critical Care Trials Group. Prognostication in critically ill patients with severe traumatic brain injury: The TBI-Prognosis multicenter feasibility study. BMJ Open. 2017 Apr 17;7(4):e013779. doi: 10.1136/bmjopen-2016-013779. PMID: 28416497
93. Boutin A, Moore L, Lauzier F, Chasse M, English S, Zarychanski R, Griesdale D, Fergusson DA, Turgeon AF. Transfusion of red blood cells in patients with traumatic brain injuries admitted to Canadian trauma health centers: a multicenter cohort study. BMJ Open. 2017 Mar 29;7(3):e014472. doi: 10.1136/bmjopen-2016-014472. PMID: 28360248
92. Chauhan BF, Jeyaraman MM, Singh Mann A, Lys J, Abou-Setta AM, Zarychanski R, Ducharme FM. Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma. Cochrane Database of Systematic Reviews 2017: Mar 16;3:CD010347. doi: 10.1002/14651858.CD010347.pub2. PMID: 28301050
91. Guillemette L, Durksen A, Rabbani R, Zarychanski R, Abou-Setta AM, Duhamel TA, McGavock JM, Wicklow B. Intensive gestational glycemic management and childhood obesity: A systematic review and meta-analysis. International Journal of Obesity. 2017. Jul;41(7):999-1004. doi: 10.1038/ijo.2017.65. [Epub ahead of print] doi: 10.1038/ijo.2017.65. PMID: 28286340
90. Chauhan BF, Jeyaraman JM, Man AS, Lys J, Skidmore B, Sibley KM, Abou-Setta AM, Zarychanski R (senior author/supervisor). Behaviour change interventions and policies influencing primary healthcare professionals' practice – An overview of reviews. Implementation Science. 2017 Jan 5;12(1):3. doi: 10.1186/s13012-016-0538-8 PMID: 28057024
Ryan Zarychanski
89. Fiest KM, Hitchon CA, Bernstein CN, Peschken CA, Walker JR, Graff LA, Zarychanski R, Abou-Setta AM, Patten SB, Sareen J, Bolton J, Marrie RA; CIHR Team “Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease: Systematic Review and Meta-Analysis of Interventions for Depression and Anxiety in Persons with Rheumatoid Arthritis. Journal of Clinical Rheumatology. 2017; 2017 Dec;23(8):425-434. doi: 10.1097/RHU.0000000000000489. PMID: 28221313
88. Coyle K , Carrier M, Lazo-Langner A, Shivakumar S, Zarychanski R, Tagalakis V, Sollymoss S, Routhier N, Douketis J, Coyle D. Cost effectiveness of the addition of a comprehensive CT scan to the abdomen and pelvis for the detection of cancer after unprovoked venous thromboembolism. Thrombosis Research. 2017; Mar;151:67-71. PMID: 28160670
87. Litster B, Fiest KM, Patten SB, Fisk JD, Walker JR, Graff LA, Bolton JM, Sareen J, Marriott JJ, Berrigan LI, Bernstein CN, Zarychanski R, Singer A, Hitchon CA, Peschken CA, Marrie RA; CIHR Team “Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease”. Screening Tools for Anxiety in People with Multiple Sclerosis: A Systematic Review. International Journal of Multiple Sclerosis Care. 2016 Nov-Dec;18(6):273-281. PMID: 27999521
86. Mercier E, Boutin A, Shemilt M, Lauzier F, Zarychanski R, Fergusson DA, Moore L, McIntyre LA, Archambault P, Légaré F, Rousseau F, Lamontagne F, Nadeau L, Turgeon AF. Predictive value of neuron-specific enolase (NSE) for prognosis in patients with moderate or severe traumatic brain injury: A systematic review and meta-analysis. CMAJ Open. 2016 Jul 22;4(3):E371-E382 PMID: 27975043
85. Ducas RA, Labos C, Allen D, Golian M, Jeyaraman M, Lys J, Mann A, Copstein L, Vokey S, Rabbani R, Zarychanski R, Abou-Setta AM, Menkis A. Association of pre-hospital ECG administration with clinical outcomes in ST-segment myocardial infarction: a systematic review and meta-analysis. Canadian Journal of Cardiology. 2016 Dec;32(12):1531-1541. doi: 10.1016/j.cjca.2016.06.004 PMID: 27707525
84. Green RS, Fergusson DA, Turgeon AF, McIntyre LA, Kovacs GJ, Griesdale DE, Zarychanski R, Butler MB, Kureshi N, Erdogan M. Resuscitation prior to emergency endotracheal intubation: Results of a national survey. Western Journal of Emergency Medicine. 2016. Sep;17(5):542-8. PMID: 27625717
83. Green RS, Fergusson DA, Turgeon AF, McIntyre LA, Kovacs GJ, Griesdale DE, Zarychanski R, Butler MB, Kureshi N, Erdogan M. Device and medication preference of Canadian physicians for endotracheal intubation in critically ill patients. Canadian Journal of Emergency Medicine. 2017 May;19(3):186-197. doi: 10.1017/cem.2016.361 PMID: 27573571
82. Dawe DE, Christiansen D, Swaminath A, Ellis PM, Rothney J, Rabbani R, Abou-Setta AM, Zarychanski R; Mahmud SM. Chemoradiotherapy versus radiotherapy alone in elderly patients with stage III non-small cell lung cancer: a systematic review and metaanalysis. Lung Cancer. 2016 Sept;99:180-185. PMID: 27565937
Ryan Zarychanski
81. Fiest KM, Bernstein CN, Walker JR, Graff LA, Hitchon CA, Peschken CA, Zarychanski R, Abou-Setta A, Patten SB, Sareen J, Bolton J, Singer A, Marrie RA; CIHR Team “Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease”. Systematic review of interventions for depression and anxiety in persons with inflammatory bowel disease. BMC Research Notes. 2016 Aug 12;9(1):404. doi: 10.1186/s13104- 016-2204-2. PMID: 27514366
80. Gould TJ, Lysov, Z, Swystun LL, Dwivedi DJ, Zarychanski R, Fox-Robichaud AE, Liaw PC on behalf of the Canadian Critical Care Translational Biology Group. Extracellular histones increase tissue factor activity and enhance thrombin generation by human blood monocytes. Shock. 2016. Dec;46(6):655-662. PMID: 27405066
79. McIntyre L, Rowe BH, Walsh TS, Gray A, Arabi Y, Perner A, Gordon A, Marshall J, Cook DJ, Fox-Robichaud A, Bagshaw SM, Green R, Scheitzer I, Turgeon AF, Zarychanski R, English S, Chassé M, Stiell I, Fergusson DA For the Canadian Critical Care Trials Group. Multicountry survey of emergency and critical care medicine physicians' fluid resuscitation practices for adult patients with early septic shock. BMJ Open. 2016. Jul 7;6(7):e010041. PMID: 27388345
78. Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Crit Care. 2016 Mar 30;20:75.
77. Reid AE, Chauhan BF, Rabbani R, Lys J, Copstein L, Mann A, Abou-Setta AM, Fiander M, MacKay DS, McGavock J, Wicklow B, Zarychanski R, Azad MB. Early exposure to non-nutritive sweeteners and long-term metabolic health: A systematic review. Pediatrics. 2016. March. Mar;137(3):e20153603. doi: 10.1542/peds.2015-3603. PMID: 26917671
76. Ali E, Abdel Wahed M, Alsalami Z, Abouseif H, Gottschalk T, Rabbani R, Zarychanski R, Abou-Setta AM. New Modalities to Deliver Surfactant in Premature Infants: A Systematic Review and Meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine. 2016 Nov;29(21):3519-24. doi: 10.3109/14767058.2015.1136997 . PMID: 26864884
75. Fiest KM, Walker JR, Bernstein CN, Graff LA, Zarychanski R, Abou-Setta AM, Patten SB, Sareen J, Bolton JM, Marriott JJ, Fisk, JD, Singer A, & Marrie RA for the CIHR Team “Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease.” Systematic Review and Meta-Analysis of Interventions for Depression and Anxiety in Persons with Multiple Sclerosis. Multiple Sclerosis and Related Disorders. 2016 Jan;5:12-26. PMID: 26856938
74. Ihaddadene R, Corsi DJ, Lazo-Langner A, Shivakumar S, Zarychanski R, Tagalakis V, Solymoss S, Routhier N, Douketis J, Le Gal G, Carrier M. Risk factors predictive of occult cancer detection in patients with unprovoked venous thromboembolism. Blood. 2016. Apr 21;127(16):2035- 7. PMID: 26817957
Ryan Zarychanski
73. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Shemilt M, Moore L, Zarychanski R, Fergusson DA, Turgeon AF. The Prognostic Value of Magnetic Resonance Imaging in Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Systematic Reviews. 2016 Jan 19;5(1):10. doi: 10.1186/s13643-016-0184-x. PMID: 26791573
72. MENARD CM, Zawadski D, Singal RK, Rimmer E, Houston DS, Zarychanski R (senior author/supervisor). Coronary artery bypass surgery in a patient with Haemophilia A: A case report. Haemophilia. 2016 Jan;22(1):e76-9. PMID: 26635300
71. Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, Zarychanski R, Griesdale D, Desjardins P, Lacroix J, Fergusson DA, Turgeon AF. Red blood cell transfusion in patients with traumatic brain injury: a systematic review and meta-analysis. Transfusion Medicine Reviews. 2016 Jan;30(1):15-24. PMID: 26409622
70. Magnan S, Zarychanski R, Pilote L, Bernier L, Shemilt M, Vigneault E, Fradet V, Turgeon AF. Intermittent versus continuous androgen deprivation therapy for prostate cancer: A systematic review and meta-analysis. JAMA Oncology. 2015 Dec;1(9):1261-9. doi: 10.1001/jamaoncol.2015.2895. PMID: 26378418
69. HOUSTON BL, Govia R, Abou-Setta AM, Reid GJ, Hadfield M, Menard C, Noyd J, Main S, Zarychanski R (senior author/supervisor). Severe Rh alloimmunization and hemolytic disease of the fetus managed with plasmapheresis, intravenous immunoglobulin and intrauterine transfusion: a case report. Transfusion and Apheresis Science. 2015 Dec;53(3):399-402. doi: 10.1016/j.transci.2015.07.010. PMID:26321100
68. Carrier M, Lazo-Langner A, Shivakumar S, Tagalakis V, Zarychanski R, Solymoss S, Routhier N, Douketis J, Danovitch K, Lee AY, Le Gal G, Wells PS, Corsi D, Ramsay T, Coyle D, Chagnon I, Kassam Z, Tao H and Rodger MA for the SOME Investigators. Screening for occult cancer in unprovoked venous thromboembolism. New England Journal of Medicine/NEJM. 2015;373(8):697- 704 PMID:26095467
67. Zarychanski R, Kumar A. What is the best heparin to treat sepsis with? [Author Reply to: The efficacy and safety of heparin in patients with sepsis: A systematic review and meta-analysis. Critical Care Medicine. 2015 June;43(6):e213. PMID:25978177
66. Fowler RA, Abdelmalik P, Wood G, Foster D, Gibney N, Bandrauk N, Turgeon, AF, Lamontagne F, Kumar A, Zarychanski R, Green R, Bagshaw S, Stelfox HT, Foster R, Dodek, P, Shaw SM, Granton, J, Lawless B, Hill A, Rose L, Adhikari NK, Scales DC, Cook DJ, Marshall JC, Martin C, Jouvet P, on behalf of the Canadian ICU Capacity Group and the Canadian Critical Care Trials Group. Critical Care capacity in Canada: results of a national cross-sectional survey. Critical Care. 2015 Apr 1;19(1):133. PMID:25888116
65. Lacroix J, Hébert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, Clayton L, McIntyre L, Callum J, Turgeon AF, Blajchman MA, Walsh TS, Stanworth SJ, Campbell H, Capellier G, Tiberghien P, Bardiaux L, van de Watering L, van der Meer NJ, Sabri E, Vo D; ABLE Investigators; Ryan Zarychanski
Canadian Critical Care Trials Group. Age of blood in critically ill adults. New England Journal of Medicine/NEJM. 2015 Apr 9;372(15):1410-8. PMID:25853745
64. RIMMER E, Houston BL, Cook DJ, Turgeon AF, Kumar A, Friesen C, Houston DS, Abou-Setta AM, Zarychanski R (senior author/supervisor). The efficacy and safety of plasmapheresis in sepsis and septic shock: A systematic review and meta-analysis. Critical Care. Dec 20;18(6):699. DOI: 10.1186/s13054-014-0699-2. PMID:25527094
63. Zarychanski R, Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E, Houston BL, McIntyre L, Fox-Robichaud AE, Hébert P, Cook DJ, Fergusson DA. The efficacy and safety of heparin in patients with sepsis: A systematic review and meta-analysis. Critical Care Medicine. 2015 Mar;43(3):511-8. PMID:25493972
62. Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D, Fowler R, Pai M, Guyatt G, Crowther MA, Warkentin TE, Devereaux PJ, Walter SD, Muscedere J, Herridge M, Turgeon AF, Geerts W, Finfer S, Jacka M, Berwanger O, Ostermann M, Qushmaq I, Friedrich JO, Cook DJ; for the PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators, the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Failure of Anticoagulant Thromboprophylaxis: Risk Factors in Medical-Surgical Critically Ill Patients. Critical Care Medicine. 2015;43:401-10. PMID:25474533
61. Gershengom HB, Wunsch H, Scales DC, Zarychanski R, Rubenfeld G, Garland A. Relationship between Arterial Catheter Use and Hospital Mortality in Intensive Care Units. JAMA Internal Medicine. 2014;174(11):1746-54. PMID: 25201069
60. Manyanga T, Froese M, Zarychanski R, Abou-Setta AM, Friesen C, Tennenhouse M, Shay BL. Pain management with acupuncture in osteoarthritis: A systematic review and meta-analysis. BMC Complement Altern Med. 2014 Aug 23;14(1):312. PMID: 25151529
59. Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, Zarychanski R, Lacroix J, Fergusson DA, Desjardins P, Turgeon AF. Red blood cell transfusion in patients with traumatic brain injury: a systematic review protocol. Systematic Reviews. 2014;3(1):66. doi: 10.1186/2046-4053-3-66 PMID: 24943006
58. Enns JE, Yeganeh A, Zarychansk R, Abou-Setta AM, Friesen C, Zahradka R, Taylor CG. The impact of Omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular events and complications in peripheral arterial disease: A systematic review and meta-analysis. BMC Cardiovascular Disorders. 2014 May 31;14:70. doi: 10.1186/1471-2261-14-70 PMID: 24885361
57. Kumar K, Singal R, Manji RA, Zarychanski R, Bell DD, Freed DH, Arora RC on behalf of the Cardiovascular Health Research in Manitoba Investigator Group. The benefits of 24/7 in-house intensivist coverage for prolonged-stay cardiac surgery patients. Journal of Thoracic and Cardiovascular Surgery. 2014;148(1):290-297 PMID: 24703332
Ryan Zarychanski
56. CUDMORE JA, Seftel MD, Sisler JJ, Zarychanski R (senior author/supervisor). Methotrexate and trimethoprim-sulfamethoxazole: Toxicity from this combination continues to occur. Canadian Family Physician. 2014:60(1):53-6. PMID: 24452563
55. AZAD MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou- Setta AM, Zarychanski R (senior author/supervisor). Probiotic Supplementation During Pregnancy or Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis. British Medical Journal/BMJ. 2013;347:f6471. PMID: 24304677
54. YAMAMOTO J, Dostmohamed H, Schacter I, Ariano RE, Lewis B, Knoll C, Katz P, Zarychanski R. (senior author/supervisor). Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced thyrotoxicosis: A case report. Journal of Clinical Apheresis. 2014;29(3):168-70. PMID: 24265247
53. Zarychanski R, Dennis J, Singh H. Challenges of population-based colorectal cancer screening and the importance of time-trend analysis when evaluating system change. Cancer Epidemiology. 2013;37:957-958 [Editorial]. PMID: 24210585
52. Bagshaw SM1, Sood MM, Long J, Fowler RA, Adhikari NK; Canadian Critical Care Trials Group H1N1 Collaborative. Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study. BMC Nephrol. 2013 Jun 13;14:123. doi: 10.1186/1471-2369- 14-123. PMID: 23763900
51. Goldenberg BA, Graff LA, Clara I, Zarychanski R, Walker JR, Carr R, Rogala L, Miller N, Bernstein CN. Is iron deficiency in the absence of anemia associated with fatigue in inflammatory bowel disease? American Journal of Gastroenterology. 2013;108:1392-1397. PMID: 24005345
50. Hallet J, Lauzier F, Mailloux O, Trottier V, Archambault P, Zarychanski R, Turgeon AF. The use of higher Platelet:RBC transfusion ratio in the acute phase of trauma resuscitation: a systematic review. Critical Care Medicine. 2013;41(12):2800-11. PMID: 23982024
49. Lauzier F, Arnold DM, Rabbat C, Heels – Ansdell D, Zarychanski R, Dodek P, Ashley BJ, Albert M, Khwaja K, Ostermann M, Skrobik Y, Fowler R, McIntyre L, Nates JL, Karachi T, Lopes RD, Zytaruk N, Finfer S, Crowther M, Cook D - For the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis. Intensive Care Medicine. 2013;39:2135-2143. PMID: 23942857
48. Williamson DR, Albert M, Heels-Ansdell D, Arnold DM, Lauzier F, Zarychanski R, Crowther M, Warkentin TE, Dodek P, Cade J, Lesur O, Lim W, Fowler R, Lamontagne F, Langevin S, Freitag A, Muscedere J, Friedrich JO, Geerts W, Burry L, Alhashemi J, Cook DJ. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors and outcomes. Chest. 2013;144(4):1207-15. PMID: 23788287
47. RIMMER E, Kumar A, Zarychanski R (senior author/supervisor). Effectiveness of human recombinant activated protein C for severe sepsis and septic shock in adult and pediatric patients: Randomized clinical trial versus nonrandomized study. Critical Care Medicine. 2013;7:e139-40 Ryan Zarychanski
[Author Reply]. PMID: 23774364
46. Zarychanski R, Turgeon AF, Abou-Setta AM. Meta-analyses of hydroxyethyl starch for volume resuscitation. Journal of the American Medical Association/JAMA. 2013;309:2209 [Author Reply]. PMID: 23736723
45. DENNIS J, Ramsay T, Turgeon AF, Zarychanski R (senior author/supervisor). Helmet Legislation and admissions to hospital for cycling related head injuries in Canadian provinces and territories: interrupted time series analysis. British Medical Journal/BMJ. 2013;346:f2674. PMID: 23674137
44. Mercier E, Boutin A, Lauzier F, Fergusson DA, Simard JF, Zarychanski R, Moore L, McIntyre LA, Archambault P, Lamontagne F, Légaré F, Randell E, Nadeau L, Rousseau F, Turgeon AF. Predictive value of S-100ß protein for prognosis in patients with moderate and severe traumatic brain injury: A systematic review and meta-analysis. British Medical Journal/BMJ. 2013;346:f1757. PMID: 23558282
43. Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC, Fergusson DA. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. Journal of the American Medical Association/JAMA. 2013 Feb 20;309(7):678-88. PMID: 23423413
42. Turgeon AF, Lauzier F, Burns KEA, Meade MO, Scales DC, Zarychanski R, Moore L, Zygun DA, McIntyre LA, Kanji S, Hébert PC, Murat V, Pagilarello G, Furgusson DA. Determination of neurological prognosis and clinical decision-making in adult patients with severe traumatic brain injury: A survey of Canadian intensivists, neurosurgeons and neurologists. Critical Care Medicine. 2013;41:1086-93. PMID: 23385104
41. Côte N, Turgeon AF, Lauzier F, Moore L, Scales DC, Bernard F, Zarychanski R, Burns KE, Meade MO, Zygun D, Simard JF, Boutin A, Brochu JG, Fergusson DA. Factors associated with the withdrawal of life-sustaining therapies in patients with severe traumatic brain injury: A multicenter cohort study. Neurocrit Care. 2013;18:154-60. PMID: 23099846
40. RIMMER E, Kumar A, Doucette S, Marshall J, Dial S, Gurka D, Dellinger RP, Sharma S, Penner C, Kramer A, Wood K, Ronald J, Kumar A, Turgeon AF, Houston DS, Zarychanski R (senior author/supervisor), and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Activated protein C and septic shock. A propensity matched cohort study. Critical Care Medicine. 2012;40:2974-2981. PMID: 22932397
39. Zhang L, Hiebert B, Zarychanski R, Arora RC, and the Cardiovascular Health Research in Manitoba Investigator Group. Preoperative anemia does not increase the risks of early surgical revascularization following myocardial infarction. Annals of Thoracic Surgery. 2013;95:542-547. PMID: 22939451
38. Zarychanski R, Schulz VP, Houston BL, Maksimova Y, Houston DS, Smith B, Rinehart J, Gallagher PG. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012;120(9):1908-1915. PMID: 22529292 Ryan Zarychanski
37. Plante J, Turgeon AF, Vigneault L, Lauzier F, Moore L, Zarychanski R, Boutin A, Nicole PC, Fergusson DA. Effect of systemic steroids on post-tonsillectomy bleeding and reinterventions: a meta-analysis of randomized control trials. British Medical Journal/BMJ 2012;345:e5389. PMID: 22930703
36. Desjardins P, Turgeon AF, Tremblay MH, Lauzier F, Zarychanski R, Boutin A, Moore L, McIntyre LA, English SW, Rigamonti A, Lacroix J, Fergusson DA. Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies. Critical Care 2012;16(2):R54. PMID: 22471943
35. McIntyre L, Fergusson DA, Rowe B, Cook DJ, Arabi Y, Bagshaw SM, Emond M, Finfer S, Fox- Robichaud A, Gray A, Green R, Hébert P, Lang E, Marshall J, Stiell I, Tinmouth A, Pagliarello J, Turgeon AF, Walsh T, Worster A, Zarychanski R, for the Canadian Critical Care Trials Group. The PRECISE RCT: Evolution of an early septic shock fluid resuscitation trial. Transfusion Medicine Reviews. 2012;26:333-341. PMID: 22222146
34. McIntyre L, Fergusson DA, Cook DJ, Rowe BH, Bagshaw S, Easton D, Emond M, Finfer S, Fox-Robichaud A, Gaudert C, Green R, Hébert PC, Marshall J, Rankin N, Stiell I, Tinmouth A, Pagliarello J, Turgeon AF, Worster A, Zarychanski R, for the Canadian Critical Care Trials Group. Fluid Resuscitation with 5% Albumin versus Normal Saline in Early Septic Shock (PRECISE): A Pilot Randomized Controlled Trial. Journal of Critical Care. 2012;27:317.e1-6. PMID: 22176806
33. Houston DS, Zarychanski R. Transfusion thresholds in high-risk patients after hip surgery. New England Journal of Medicine/NEJM. 2012;366:1253 [Letter]. PMID: 22455422
32. SAEED M, Rubinger M, Ahsanuddin A, Morales C, Penner B, Robinson D, Zarychanski R (senior author/supervisor). If at first you don’t succeed: Try, try again. American Journal of Hematology. 2012;87:295-7. PMID: 22086437
31. Olafson K, Ramsey C, Kumar A, STASIUK A, Ariano R, Siddiqui F, Wong D, Guinn A, Braun J, Zarychanski R (senior author/supervisor). Sedation and analgesia usage in severe H1N1 (2009) infection: A comparison to respiratory failure secondary to other infectious pneumonia. Annals of Pharmacotherapy. 2012;46:9-20. PMID: 22170974
30. HOUSTON BL, Zelinski T, Israels SJ, Coghlan G, Chodirker BN, Gallagher PG, Houston DS, Zarychanski R (senior author/supervisor). Refinement of the hereditary xerocytosis locus on chromosome 16q in a large Canadian kindred. Blood Cells, Molecules and Diseases. 2011;47(4):226-231. PMID: 21944700
29. Hayani O, Al-Beihany A, Chou A, Zarychanski R, Kharaba A, Baxter A, Petal R, Allan D. Impact of critical care outreach on hematopoietic stem cell transplant recipients: a cohort study. Bone Marrow Transplantation. 2011;46:1138-1144. PMID: 20972465
28. Zarychanski R. From mice to men: Treating sepsis with heparin. Critical Care Medicine. 2011;39:1225-6 [Editorial]. PMID: 21610590 Ryan Zarychanski
27. Rajasekhar A, Gowing R, Zarychanski R, Arnold D, Lim W, Crowther M, Lottenberg R. Survival of trauma patients after massive red blood cell transfusion using a high or low red blood cell to plasma transfusion ratio. Critical Care Medicine. 2011;39(6):1507-13. PMID: 21336132
26. Vigneault L, Turgeon AF, Côté D, Lauzier F, Zarychanski R, Moore L, McIntyre LA, Nicole PC, Fergusson DA. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Canadian Journal of Anesthesia. 2011;58:22-37. PMID: 21061107
25. Kumar A, Zarychanski R, Light B, Parrillo JE, Maki D, Simon D, Laporta D, Lapinsky S, Ellis P, Mirzanejad Y, Martinka G, Keenan S, Wood G, Arabi Y, Feinstein D, Kumar A, Dodek P, Kravetsky L, Doucette S; the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Early combination antibiotic therapy yields improved survival compared to monotherapy in septic shock: A propensity-matched analysis. Critical Care Medicine. 2010;38(9):1773-1785. PMID: 20639750
24. DENNIS J, Potter B, Ramsay T, Zarychanski R (senior author/supervisor). The effects of provincial bicycle helmet legislation on helmet use and recreational bicycle ridership in Canada. Injury Prevention. 2010;16(4):219-24. PMID: 20587815
23. OLUYOMI-OBI T, Avery L, Schneider C, Kumar A, Lapinsky S, Menticoglou S, Zarychanski R (senior author/supervisor). Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza A. Journal of Obstetrics and Gynaecology Canada. 2010;32(5):443–447. PMID: 20500952
22. Sood MM, Rigatto C, Zarychanski R, Komenda P, Sood AR, Bueti J, Reslerova M, Roberts D, Mojica J, Kumar A. Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): Report for a Canadian Province. The American Journal of Kidney Disease. 2010;55:848-55. PMID: 20303633
21. Ariano RE, Sitar DS, Zelenitsky SA, Zarychanski R, Pisipati A, Ahern A, Kanji S, Rello J, Kumar A. Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza. Canadian Medical Association Journal/CMAJ. 2010;182(4):357-363. PMID: 20159892
20. Zarychanski R, Stuart TL, Kumar A, Doucette S, Elliott L, Kettner J, Plummer FA. Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection. Canadian Medical Association Journal/CMAJ. 2010;182(3):257-264. PMID: 20093297
19. Freed DH, Henzler D, White CW, Fowler R, Zarychanski R, Hutchison J, Arora RC, Manji RA, Legare JF, Drews T, Veroukis S, Kesselman M, Guerguerian AM, Kumar A for the Canadian Critical Care Trials Group. Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada. Canadian Journal of Anaesthesia. 2010;57(3):240-7. PMID: 20082167
18. Houston DS, Zarychanski R. Dabigatran versus warfarin in patients with atrial fibrillation. Ryan Zarychanski
New England Journal of Medicine/NEJM. 2009;361(27):2671 [Letter]. PMID: 20042760
17. Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern S, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Sing J, Karachi T, Wiebe K3, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler R, Canadian Critical Care Trials Group H1N1 Collaborative, on behalf of the Canadian Critical Care Trials Group. Critically ill patients with 2009 influenza A (H1N1) infection in Canada. Journal of the American Medical Association/JAMA. 2009:302(17);1872-1879. PMID: 19822627
16. Smetanin P, Stiff D, Kumar A, Kobak P, Zarychanski R, Simonsen N, Plummer FA. Potential ICU Ventilator Demand/Capacity Mismatch due to Novel soH1N1 in Canada. Canadian Journal of Infectious Diseases and Medical Microbiology. 2009;20(4):e115-e123. PMID: 21119787
15. Zarychanski R, Turgeon AF, Fergusson DA, Cook DJ, Hébert PC, Bagshaw SM, Monsour D, McIntyre. Renal outcomes and mortality following hydroxyethyl starch resuscitation of critically ill patients: systemic review and meta-analysis of randomized trials. OPEN Medicine. 2009;3(4):E196- 209. PMID: 21688756
14. Ahmad S, Tejuja A, Newman KD, Zarychanski R, Seely AJ. Clinical review: a review and analysis of heart rate variability and the diagnosis and prognosis of infection. Critical Care. 2009;13(6):232. PMID: 20017889
13. Gin A, Kumar A, Zarychanski R, Honcharik N. Increased sedative and antibiotic use in H1N1 ICU Patients. Canadian Medical Association Journal/CMAJ. 14 Sept 2009 [Letter].
12. KUMAR K, Zarychanski R, Bell DD, Manji R, Zivot J, Menkis A, Arora R on behalf of the Cardiovascular Health Research in Manitoba Investigator Group (CHaRM) Investigator Group. The Impact of Twenty-Four Hour In-House Intensivists on a Dedicated Cardiac Surgery Intensive Care Unit. Annals of Thoracic Surgery. 2009;88(4):1153-1161. PMID: 19766800
11. Zarychanski R, Ariano R, Paunovic B, Bell D. Historical perspectives in critical care medicine: blood transfusion, intravenous fluids, inotropes/vasopressors, and antibiotics. Critical Care Clinics. 2009;25(1):201-220 [Review]. PMID: 19268803
10. Zarychanski R, Doucette S, Fergusson D, Roberts D, Houston DS, Sharma S, Gulati H, Kumar A. Early intravenous unfractionated heparin and mortality in septic shock. Critical Care Medicine. 2008;36(11):2973-79. PMID: 18824906
9. Zarychanski R, Houston DS. Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response? Canadian Medical Association Journal/CMAJ. 2008;179(4):333-7 [Review]. PMID: 18695181
8. Zarychanski R, Dhaliwal D. Rates of colorectal cancer screening. Canadian Medical Association Journal/CMAJ. 2008;178(11):1465 [Author reply]. PMID: 18490644
Ryan Zarychanski
7. Zarychanski R, Turgeon AF, McIntyre L, Fergusson DA. Erythropoietin-receptor agonists in critically ill patients: a meta-analysis of randomized controlled trials. Canadian Medical Association Journal/CMAJ. 2007;177(7): 725-734. PMID: 17823140
6. Zarychanski R, Chen Y, Bernstein C, Hébert PC. Frequency of colorectal cancer screening and the impact of family physicians on screening behaviour. Canadian Medical Association Journal/CMAJ. 2007;177(6); 593-7. PMID: 17846441
5. Zarychanski R, Wlodarczyk K, Ariano R, Bow E. Pharmacokinetic interaction between methotrexate and piperacillin/tazobactam resulting in prolonged toxic concentrations of methotrexate. Journal of Antimicrobial Chemotherapy. 2006; 58(1):228-30. PMID: 16717053
4. Zarychanski R, Elphee E, Walton P, Johnston J. Osteonecrosis of the jaw associated with pamidronate therapy. American Journal of Hematology. 2006;81(1):73-75. PMID: 16369966
3. Zarychanski R, Houston DS. Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability. Thrombosis & Haemostasis. 2004;91(6):1115-22. PMID: 15175797
2. Becker ML, Suchak AA, Wolfe JN, Zarychanski R, Kabani A, Nicolle LE. Mycobacterium neoaurum bacteremia in a hemodialysis patient. Canadian Journal of Infectious Diseases. 2003;14(1):45-48. PMID: 18159425
1. Veinot JP, Mai KT, Zarychanski R. Chloroquine related cardiac toxicity. Journal of Rheumatology. 25(6):1221-1225, 1998. PMID: 9632091 Ryan Zarychanski
BOOK CHAPTERS
6. Houston DS, Zarychanski R. (2019). Bleeding and Thrombosis in the ICU. In. LaRosa JA, (Ed.) Adult Critical Care Medicine: A Clinical Casebook. (pp. 299-313.) Cham, Switzerland. Springer. ISBN 978-3-319-94424-1 (eBook). https://doi.org/10.1007/978-3-319-94424-
5. HOUSTON BL, Houston DS, Zarychanski R (senior author/supervisor). (July 2015) Anaemia Overview: In: eLS Citable reviews in the life sciences. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0002156.pub2]
4. Zarychanski R, Rimmer E, Houston DS. (September 2012) Anemia: Adaptive mechanisms and consequences. In: eLS Citable reviews in the life sciences. John Wiley & Sons Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0002157.pub2].
3. Zarychanski R, Turgeon A, Hébert PC, Tinmouth A. Transfusion. In: Core topics in cardiothoracic critical care. Klein A, Vuylsteke A, Nashef S, editors. Cambridge University Press, 2008.
2. Darovic G, Zarychanski R, Kumar A. Swan Ganz. Catheterization. In: Hemodynamic Monitoring: Invasive and Noninvasive Clinical Application. Darovic G, editor. Philadelphia: Saunders, 2007.
1. Zarychanski R. Collaborative Reviewer. The Year Book of Critical Care Medicine. Eds. Dellinger P, Parrillo J. Philadelphia: Elsevier Mosby, 2006.
Ryan Zarychanski
SUPERVISED STUDENT PUBLICATIONS
MENARD CE, Kumar A, Houston DS, Turgeon AF, Rimmer E, Houston BL, Doucette S, Zarychanski R (senior author/supervisor). Evolution and impact of thrombocytopenia in septic shock: a retrospective cohort study. Critical Care Medicine. 2019. Apr;47(4):558-565. doi: 10.1097/CCM.0000000000003644. PMID: 30855327
UMINSKI K, Kadkhoda K, Houston BL, Lopez A, McKenzie L, Lindsay R, Walkty A, Embil J, Zarychanski R (senior author/supervisor). Anaplasmosis: an emerging tick-born disease of importance in Canada. ID Cases. 2018 Nov 28;14:e00472. doi: 10.1016/j.idcr.2018.e00472. eCollection 2018. PMID: 30524954
LODEWYKS C, Heinrichs J, Grocott H, Karkouti K, Romund G, Arora R, Tangri N, Rabbani R, Abou-Setta AM, Zarychanski R (senior author/supervisor). Point of care viscoelastic hemostatic testing in cardiac surgery: A systematic review and meta-analysis. Canadian Journal of Anesthesia. 2018. 2018 Sep 7. doi: 10.1007/s12630-018-1217-9. PMID: 30194674
LEEIES M, Flynn E, Turgeon AF, Paunovic B, Loewen H, Rabbani R, Abou-Setta AM, Ferguson N, Zarychanski R (senior author/supervisor). High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: A systematic review and meta-analysis. Systematic Reviews. 2017;6:202. DOI 10.1186/s13643-017-0593-5 PMID: 29037221
BEDNARCZYK JM, Fridfinnson JA, Kumar A, Blanchard L, Rabbani R, Bell D, Funk D, Turgeon AF, Abou-Setta AM, Zarychanski R. Incorporating dynamic assessment of fluid responsiveness into goal-directed therapy: A systematic review and meta-analysis. Critical Care Medicine. 2017. Sep;45(9):1538-1545. doi: 10.1097/CCM.0000000000002554. PMID: 28817481
MENARD CM, Zawadski D, Singal RK, Rimmer E, Houston DS, Zarychanski R (senior author/supervisor). Coronary artery bypass surgery in a patient with Haemophilia A: A case report. Haemophilia. 2016 Jan;22(1):e76-9. PMID: 26635300
HOUSTON BL, Govia R, Abou-Setta AM, Reid GJ, Hadfield M, Menard C, Noyd J, Main S, Zarychanski R (senior author/supervisor). Severe Rh alloimmunization and hemolytic disease of the fetus managed with plasmapheresis, intravenous immunoglobulin and intrauterine transfusion: a case report. Transfusion and Apheresis Science. 2015 [Epub ahead of print]. PMID:26321100
HOUSTON BL, Houston DS, Zarychanski R (senior author/supervisor). (July 2015) Anaemia Overview: In: eLS Citable reviews in the life sciences. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0002156.pub2]
RIMMER E, Houston BL, Cook DJ, Turgeon AF, Kumar A, Friesen C, Houston DS, Abou-Setta AM, Zarychanski R* (*senior author/supervisor). The efficacy and safety of plasmapheresis in sepsis and septic shock: A systematic review and meta-analysis. Critical Care. 2014, 18:699 DOI: 10.1186/s13054-014-0699-2. PMID:25527094
Ryan Zarychanski
CUDMORE JA, Seftel MD, Sisler JJ, Zarychanski R (senior author/supervisor). Methotrexate and trimethoprim-sulfamethoxazole: Toxicity from this combination continues to occur. Canadian Family Physician. 2014:60(1):53-6. PMID: 24452563
AZAD MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta AM, Zarychanski R (senior author/supervisor). Probiotic Supplementation During Pregnancy or Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis. British Medical Journal/BMJ. 2013;347:f6471. PMID: 24304677
YAMAMOTO J, Dostmohamed H, Schacter I, Ariano RE, Lewis B, Knoll C, Katz P, Zarychanski R. (senior author/supervisor). Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced thyrotoxicosis: A case report. Journal of Clinical Apheresis. 2014;29(3):168- 70. PMID: 24265247
RIMMER E, Kumar A, Zarychanski R* (*senior author/supervisor). Effectiveness of human recombinant activated protein C for severe sepsis and septic shock in adult and pediatric patients: Randomized clinical trial versus nonrandomized study. Critical Care Medicine. 2013;7:e139-40 [Author Reply]. PMID: 23774364
DENNIS J, Ramsay T, Turgeon AF, Zarychanski R (senior author/supervisor). Helmet Legislation and admissions to hospital for cycling related head injuries in Canadian provinces and territories: interrupted time series analysis. British Medical Journal/BMJ. 2013;346:f2674. PMID: 23674137
RIMMER E, Kumar A, Doucette S, Marshall J, Dial S, Gurka D, Dellinger RP, Sharma S, Penner C, Kramer A, Wood K, Ronald J, Kumar A, Turgeon AF, Houston DS, Zarychanski R (senior author/supervisor), and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Activated protein C and septic shock. A propensity matched cohort study. Critical Care Medicine. 2012;40:2974-2981. PMID: 22932397
SAEED M, Rubinger M, Ahsanuddin A, Morales C, Penner B, Robinson D, Zarychanski R (senior author/supervisor). If at first you don’t succeed: Try, try again. American Journal of Hematology. 2012;87:295-7. PMID: 22086437
Olafson K, Ramsey C, Kumar A, STASIUK A, Ariano R, Siddiqui F, Wong D, Guinn A, Braun J, Zarychanski R (senior author/supervisor). Sedation and analgesia usage in severe H1N1 (2009) infection: A comparison to respiratory failure secondary to other infectious pneumonia. Annals of Pharmacotherapy. 2012;46:9-20. PMID: 22170974
HOUSTON BL, Zelinski T, Israels SJ, Coghlan G, Chodirker BN, Gallagher PG, Houston DS, Zarychanski R (senior author/supervisor). Refinement of the hereditary xerocytosis locus on chromosome 16q in a large Canadian kindred. Blood Cells, Molecules and Diseases. 2011;47(4):226-231. PMID: 21944700
DENNIS J, Potter B, Ramsay T, Zarychanski R (senior author/supervisor). The effects of provincial bicycle helmet legislation on helmet use and recreational bicycle ridership in Canada. Injury Prevention. 2010;16(4):219-24. PMID: 20587815
Ryan Zarychanski
OLUYOMI-OBI T, Avery L, Schneider C, Kumar A, Lapinsky S, Menticoglou S, Zarychanski R (senior author/supervisor). Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza A. Journal of Obstetrics and Gynaecology Canada. 2010;32(5):443–447. PMID: 20500952
KUMAR K, Zarychanski R, Bell DD, Manji R, Zivot J, Menkis A, Arora R on behalf of the Cardiovascular Health Research in Manitoba Investigator Group (CHaRM) Investigator Group. The Impact of Twenty-Four Hour In-House Intensivists on a Dedicated Cardiac Surgery Intensive Care Unit. Annals of Thoracic Surgery. 2009;88(4):1153-1161. PMID: 19766800
Ryan Zarychanski
ABSTRACTS/POSTERS/ORAL PRESENTATIONS (CONFERENCE PUBLICATIONS)
105. OBEROI S, Yang J, Woodgate RL, Niraula S, Banerji S, Israels SJ, Altman G, Beattie S, Rabbani R, Askin N, Gupta A, Sung L, Abou-Setta AM, Zarychanski R (senior author/supervisor). Mindfulness-based interventions to reduce anxiety in adults and children with cancer: A systematic review and meta-analysis. Society for Integrative Oncology. 16th International Conference. October 20, 2019. New York, NY, USA. [Poster Presentation].
104. Jeyaraman MM, Shimmin C, Beaudry T, Hartwell M, Akbaraly Z, Zarychanski R, Abou-Setta AM, & PIERO-Group. Partnering with healthcare consumers during the design and conduct of a Systematic Review: A case study. Cochrane Colloquium. October 23, 2019. Santiago, Chile [Oral Presentation].
103. LEESIES M, Gershengorn H, Siddiqui F, Garland A, Houston DS, Houston BL, Rimmer E, Balshaw R, Charbonney E, Kumar A, Katz A, Zarychanski R (senior author/supervisor), for the Acute Care Hematology Research Group. Intravenous Immunoglobulin in Septic Shock. CancerCare Manitoba Research Day. May 7, 2019. Winnipeg, Canada [Oral Presentation].
102. RIMMER E, Doucette S, Houston DS, Houston BL, Menard CE, Leeies M, Mahmud S, Kumar A, Garland A, and Zarychanski R (senior author/supervisor); for the Acute Care Hematology Research Cluster. White Blood Cell Count Trajectory and Mortality in Septic Shock: A Retrospective Cohort Study. American Society of Hematology Annual Meeting. December 4, 2018. (San Diego, USA) [Poster Presentation].
101. HOUSTON BL, Krupka E, Mutter T, Falk J, Colas J, Murphy M, Breau R, Turgeon AF, Fergusson DA, Zarychanski R (senior author/supervisor). A Contemporary Evaluation of Red Blood Cell Transfusion Practices in High Risk Non-Cardiac Surgeries: A Retrospective Cohort Study. American Association of Blood Banks. October 14, 2018. (Boston, USA) [Poster Presentation].
101. HOUSTON BL, Krupka E, Mutter T, Falk J, Colas J, Murphy M, Breau R, Turgeon AF, Fergusson DA, Zarychanski R (senior author/supervisor). Perioperative Tranexamic Acid Utilization Patterns in High-Risk Non-Cardiac Surgery: A Retrospective Cohort Study. American Association of Blood Banks. October 14, 2018. (Boston, USA) [Poster Presentation].
100. VAZQUEZ-GRANDE G, Graydon C, Loewen H, Rabbani R, Abou-Setta AM, Zarychanski R, Kumar A. Antimicrobial combination therapy in septic patients: a systematic review and meta- analysis. European Society of Intensive Care Medicine. (ESICM). Paris, France. October 22, 2018 [Poster].
Ryan Zarychanski
99. Okoli G, Rabbani R, Kashani HH, Wierzbowski AK, Neilson C, Mansouri B, Zarychanski R, Abou-Setta AM. Vitamin and mineral supplements for migraine prophylaxis: A systematic review and meta-analysis of randomized controlled trials. Pain and Migraine Summit 2018. October 10, 2018. (San Francisco, USA) [Poster Presentation].
98. Mortaza N, Abou-Setta AM, Zarychanski R, Loewen H, Rabbani R, Glazebrook CM. Upper Limb Tendon/Muscle Vibration in Persons with Chronic Stroke: A Systematic Review and Meta- analysis. Canadian Society for Psychomotor Learning and Sport Psychology (SCAPPS). October 18, 2018. (Toronto, Canada) [Poster Presentation].
97. HOUSTON BL, Krupka E, Mutter T, Fergusson DA, Falk J, Colas JA, Murphy M, Breau R , Turgeon AF, Zarychanski R. Perioperative tranexamic acid utilization patterns in high-risk non- cardiac surgery: A retrospective cohort study. Perioperative Care Congress. May 12, 2018. (Toronto, Canada) [Poster Presentation].
96. HOUSTON BL, Krupka E, Mutter T, Fergusson DA, Falk J, Colas JA, Murphy M, Breau R , Turgeon AF, Zarychanski R. A contemporary evaluation of red blood cell transfusion practices in high-risk non-cardiac surgeries: A retrospective cohort study. Perioperative Care Congress. May 12, 2018. (Toronto, Canada) [Poster Presentation].
95. RIMMER E, Houston DS, Houston BL, Kumar A, Mahmud S, Leeies M, Menard CE, Garland A, Zarychanski R (senior author/supervisor); for the Acute Care Hematology Research Cluster. White Blood Cell Count Trajectory and Mortality in Septic Shock: A Retrospective Cohort Study. Manitoba Health Student Research Day (as part of the 31st Annual Canadian Student Health Research Forum. June 12, 2018. (Winnipeg, Canada) [Poster Presentation].
94. HOUSTON BL, Uminski K, Mutter T, Rimmer E, Houston DS, Garland A, Mahmud S, Menard CE, Leeies M, Fergusson DA, Turgeon AF, Colas J, Murphy M, Park J, Muirhead B, Falk J, Zarychanski R (senior author/supervisor); for the Acute Care Hematology Research Group. Identification of red blood cell transfusion rates and tranexamic acid use, efficacy and safety in high- risk non-cardiac surgeries. CancareCare Research Day. May 29, 2018. Winnipeg, Canada [Oral Presentation].
93. MENARD CE, Ismath M, Chiborak S, Paul S, Muirhead B, Garland A, Kumar A, Houston DS, Rimmer E, Houston BL, Leeies M, Sun P, Musuka C, Logetty S, Gray P, Zarychanski R (senior author/supervisor); for the Acute Care Hematology Research Group. Massive Transfusion: Improving processes of care and clinical outcomes through systems change. CancareCare Research Day. May 29, 2018. Winnipeg, Canada [Oral Presentation].
92. GRANT L, Jeyaraman MM, Abou-Setta AM, Farshidfar F, Copstein L, Lys J, Singh Mann A, Gottschalk T, Pitz M, Zarychanski R (senior author/supervisor). Dairy product consumption and Ryan Zarychanski
risk of cancer – An overview of reviews. CancareCare Research Day. May 29, 2018. Winnipeg, Canada [Poster].
91. Verret M, Savard X, Cossi MJ, Lauzier F, Pinard AM, Leger C, Zarychanski R, Turgeon AF. L’utilisation des gabapentinoïdes pour la gestion de la douleur aiguë postopératoire : une revue systématique et méta-analyse. 7e Édition de Colloque Annuel Réseau Québécois de Recherche sur les Médicaments. Château Laurier, Québec. September 30, 2017 [Poster].
90. HOUSTON BL, Hurrie D, Graham J, Perija B, Rimmer E, Abou-Setta AM, Bernstein CN, Houston DS, Zarychanski R. (senior author/supervisor). Efficacy of iron replacement therapy on fatigue and work capacity in non-anemic adults with iron depletion: a systematic review of randomized controlled trials. Manitoba. American Society of Hematology. Atlanta, GA, U.S.A. December 2017 [Poster].
89. LODEWYKS C, Heinrichs J, Grocott H, Romound G, Rabbani R, Abou-Setta AM, Zarychanski R. (senior author/supervisor). The use of viscoelastic hemostatic testing in cardiac surgery patients: A systematic review and meta-analysis. Cardiac Sciences Program 15th annual Research Symposium. University of Manitoba, St. Boniface Hospital. May 29, 2017. Winnipeg, MB [Oral Presentation].
88. Bhupendrasinh CF, Rabbani R, Lys J, Wierzbowski K, Nazmus M, Abou-Setta AM, Zarychanski R, McGavock J. Lay- or expert led interventions for weight loss in overweight children and adolescents, what works? A systematic review and network meta-analysis. Diabetes Canada. Professional Conference & Annual Meetings. Edmonton, AB. November 2, 2017 [Poster].
87. Jeyaraman MM, Rabbani R, Copstein L, Sulaiman W, Farshidfar F, Kashani H, Qadar SMZ, Guan Q, Skidmore B, Dias S, Kardami E, Ducas J, Mansour S, Zarychanski R, Abou-Setta AM. Autologous Bone Marrow Stem Cell Therapy in Patients with ST-elevation Myocardial Infarction: A Systematic Review and Meta-analysis. International Society for Heart Research (ISHR) – North American Section Meeting. New Orleans, LA. U.S.A. May 31, 2017 [Poster].
86. Ruel-Laliberté J, Fergusson D, Zarychanski R, Lauzier F, Lacroix J, Paule Lessard B, Tinmouth A, Green R, Griesdale D, Fowler R, Kramer A, McIntyre L, Zygun D, Walsh T, Stanworth S, Léger C, Turgeon AF. Effect of age of transfused red blood cells on neurological outcome in critically ill patients with traumatic brain injury (ABLE-tbi Study). International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March 2017 [Poster].
85. PERIJA B, Houston DS, Kotb R, Israels S, Rimmer E, Zarychanski R (senior author/supervisor). Acquired Hemophilia: a population based study of incidence, hemorrhage and treatment outcomes in Manitoba. American Society of Hematology. San Diego, U.S.A. December 2016 [Poster].
Ryan Zarychanski
84. Leeies M, Flynn E, Turgeon AF, Paunovic B, Loewen H, Rabbani R, Abou-Setta AM, Fergusson ND, Zarychanski R (senior author/supervisor). High-flow oxygen via nasal cannulae in acute hypoxemic respiratory failure: A systematic review and meta-analysis. Canadian Critical Care Forum. Toronto, Canada, November 2016 [Poster].
83. Guillemette L, Durksen A, Wicklow B, Rabbani R, Zarychanski R, Abou-Setta A, Duhamel T, McGavock J. (2016) Intensive gestational glycemic management and childhood obesity: A systematic review and meta-analysis. October 29, 2016. Canadian Diabetes Association Professional Conference. Ottawa, Canada. Published in, Canadian Journal of Diabetes. 40(5):S16. [Oral Presentation].
82. MENDARD CE, Kumar A, Turgeon AF, Rimmer R, Doucette S, Houston BL, Houston DS, Zarychanski R. Evolution and impact of thrombocytopenia in septic shock. European Society of Intensive Care Medicine. (ESICM). Milan, Italy. October 4, 2016 [Poster].
81. Duan EH, Johnstone J, Meade MO, Marshall JC, Lauzier F, Mehta S, Dodek PM, McIntyre L, Hall R, Ovakim D, Wood G, Pagliarello G, Henderson W, Golan E, Herridge M, Karachi T, Lamontagne F, Charbonneau E, Zarychanski R, Taylor R, Cartin-Ceba R, Cook DJ for the PROSPECT Pilot Trial Investigators and the CCCTG. Refining exclusion criteria following pilot trials: Lessons from PROSPECT. Canadian Critical Care Forum. Toronto, Canada, November 2016 [Poster].
80. PERIJA B, Houston DS, Kotb R, Israels S, Rimmer E, Zarychanski R (senior author/supervisor). Acquired Hemophilia: a population based study of incidence, hemorrhage and treatment outcomes in Manitoba. Cancercare Manitoba Research Day. Winnipeg, Manitoba. May 2016 [Poster].
79. MENARD CE, Kumar A, Turgeon AF, Rimmer R, Doucette S, Houston BL, Houston DS, Zarychanski R (senior author/supervisor). Evolution and impact of thrombocytopenia in septic shock. Internal Medicine Resident Research Day. Winnipeg, Manitoba. April 2016 [Oral Presentation].
78. Ali E, Abdel Wahed M, Alsalami Z, Abouseif H, Gottschalk T, Rabbani R, Zarychanski R, Abou-Setta AM. New Modalities to Deliver Surfactant in Premature Infants: A Systematic Review and Meta-analysis. Pediatric Academic Societies (PAS). May, 2016. Baltimore, U.S.A. [Poster].
77. Boutin A, Moore L, Chasse M, Zarychanski R, Lauzier F, English S, McIntyre L, Lacroix J, Griesdale D, Fergusson DA, Desjardins P, Turgeon AF on behalf of the Canadian Critical Care Trials Group. Transfusion of red blood cells in patients with traumatic brain injury admitted to Canadian trauma health centers: a multicenter cohort study. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March 2016 [Poster].
76. Boutin A, Moore L, Green RS, Lessard-Bonaventure P, Erdogan M, Butler M, Lauzier F, Chasse M, English S, McIntyre L, Zarychanski R, Lacroix J, Griesdale D, Desjardins P, Fergusson DA, Ryan Zarychanski
Turgeon AF. Hemoglobin thresholds and red blood cell transfusions in adult patients with moderate or severe traumatic brain injury: a retrospective cohort study. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March 2016 [Poster].
75. English SW, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Garland A, Fergusson DA, Zarychanski R, Tinmouth A, van Walraven C, Montroy K, Ziegler J, Dupont Chouinard R, Carignan R, Dhaliwal A, Lum C, Sinclair J, Pagliarello G, and McIntyre L for the SAHaRA Investigators and the CCCTG. Aneurysmal subarachnoid hemorrhage and anemia: a Canadian multi-centre retrospective cohort study. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March 2016 [Poster].
74. English SW, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Garland A, Fergusson DA, Zarychanski R, Tinmouth A, van Walraven C, Montroy K, Ziegler J, Dupont Chouinard R, Carignan R, Dhaliwal A, Lum C, Sinclair J, Pagliarello G, and McIntyre L for the SAHaRA Investigators and the CCCTG. Red blood cell transfusion in aneurysmal subarachnoid hemorrhage – the SAHaRA cohort study. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March 2016 [Poster].
73. HOUSTON BL, Dwivedi DJ, Grin P, Kwong M, Rullo E, Khan MA, Asma S, Pare G, Liaw PC, Zarychanski R, Fox-Robichaud AF, for the Canadian Critical Care Translational Biology Group. Biological rational for the use of heparin in septic shock: translational data from the HALO pilot RCT. American Society of Hematology, Orlando, FL, December 2015 [Poster].
72. English SW, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Garland A, Fergusson DA, Zarychanski R, Montroy K, Ziegler J, Dupont Chouinard R, Carignan R, Dhaliwal A, van Walraven C, Lum C, Sinclair J, Pagliarello G, Tinmouth A, McIntyre L for the SAHaRA investigators and the Canadian Critical Care Trials Group. Anemia is common following aneurysmal subarachnoid hemorrhage: SAHaRA – a Canadian multicenter retrospective cohort study. Canadian Critical Care Forum. Toronto, Canada, October 2015 [Oral Presentation].
71. Laflamme M, Haghbayan H, Boutin A, Shemilt M, Douville V, Lauzier F, Moore L, Zarychanski R, English S, Turgeon AF. Statins and Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis. Neurocritical Care Society. Scottsdale, Arizona, October 2015 [Poster].
70. BEDNARCZYK JM, Fridfinnson JA, Kumar A, Blanchard L, Rabbani R, Bell D, Funk D, Turgeon AF, Abou-Setta AM, Zarychanski R. (senior author/supervisor). Incorporating fluid responsiveness into goal-directed therapy – does it affect outcome? A systematic review and meta- analysis. SMACC (Social Media and Critical Care). Chicago, U.S.A. June 24, 2015 [Poster].
69. DAWE DE, Christiansen D, Zarychanski R, Abou-Setta AM, Ellis PM, Swaminath A, Rothney J, Rabbani R, Mahmud S. Chemoradiotherapy versus radiotherapy alone in elderly patients with Stage III non-small cell lung cancer: a systematic review. World Conference on Lung Cancer. Denver, Colorado, U.S.A. September 6th, 2015. [Poster]
Ryan Zarychanski
68. Reid AE, Fiander M, Rabbani R, MacKay DS, McGavock J, Wicklow B, Abou-Setta AM, Zarychanski R, Azad MB. Do non-nutritive sweeteners have adverse effects on metabolic health in infants and children? A systematic review of randomized controlled trials and prospective cohort studies. Canadian Nutrition Society. 2015 Annual Conference. Winnipeg, Canada. May 28, 2015 [Poster].
67. BORESKI P, Arora R, Hiebert B, Garland A, Doucette S, Zarychanski R. (senior author/supervisor). Massive transfusion: Impact of plasma to red cell ratio in cardiothoracic surgery. CancerCare Research Day. CancerCare Manitoba. Winnipeg, Canada. April 21, 2015. [Oral Presentation]
66. Perija B, Kotb R, Rimmer E, Houston DS, Zarychanski R. (senior author/supervisor). Acquired hemophilia presenting with spontaneous bleeding. Department of Internal Medicine Research Day. University of Manitoba. Winnipeg, Canada. April 21, 2015. [Poster]
65. Shemilt M, Laforest JF, Lauzier F, Boutin A, Fergusson DA, Zarychanski R, Moore L, McIntyre LA, Nadeau L, Turgeon AF. Prognostic value of Ubiquitin carboxy-terminal hydrolase L- 1 (UCH-L1) in patients with moderate or severe traumatic brain injury: A systematic review. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March 2015 [Poster].
64. Zarychanski R, Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E, Houston BL, McIntyre L, Fox-Robichaud AE, Hébert PC, Cook DJ, Fergusson DA, for the Canadian Critical Care Trials Group. The efficacy and safety of heparin in patients with sepsis: A systematic review and meta-analysis. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March 2015 [Poster].
63. Whitney D, Klassen K, Holmqvist, M, Bailly M, Abou-Setta, AM, Friesen C, Zarychanski R. (senior author/supervisor). Effectiveness & Safety of Videoconference Psychotherapy for PTSD: A Systematic Review and Meta-analysis. Canadian Institute for Military and Veteran Health Research Forum. Toronto, Canada. November, 2014.
62. Lalonde G, Boutin A, Desjardins P, Lauzier F, Moore L, Zarychanski R, Fergusson DA, Turgeon AF. Outcome measures in severe traumatic brain injury: a systematic review. Canadian Critical Care Forum. Toronto, Canada, November 2014 [Poster].
61. Lodewyks C, Bednarczyk J, Mooney O, Zarychanski R, Singal R. Extracorporeal membrane oxygenation, pulmonary embolectomy, and right ventricular assist device for massive pulmonary embolus: a case report and literature review. Canadian Critical Care Forum. Toronto, Canada, November 2014 [Poster].
60. HURRIE D, Graham J, Rimmer E, Abou-Setta A, Bernstein CN, Houston DS, Zarychanski R. (senior author/supervisor). Efficacy of iron replacement therapy on fatigue and work capacity in non- anemic adults with iron depletion: a systematic review of randomized controlled trials. International Calgary Running Symposium. Calgary, Canada August 2014 [Poster].
Ryan Zarychanski
59. Singal D, Menard C, Friesen C, Zarychanski R, Hanlon-Dearmnan A, Chudley A, Brownell M, Abou-Setta AM. A systematic review of treatments for children and adolescents with fetal alcohol spectrum disorders. Living well: FASD and Mental Health Conference. Winnipeg, Canada. November 2014 [Oral Presentation].
58. Tetrault S, Boutin A, Chasse M, Leblanc G, Shemilt M, Lauzier F, Zarychansk R, Fergusson DA, Turgeon AF. Withdrawal of life-sustaining therapy in clinical trials in critical care: a systematic review. European Society of Intensive Care Medicine, Barcelona, Spain. September 2014. [Poster Presentation]
57. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Shemilt M, Moore L, Zarychanski R, Fergusson DA, Turgeon AF. The Prognostic Value of Magnetic Resonance Imaging in Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. European Society of Intensive Care Medicine, Barcelona, Spain. September 2014. [Poster Presentation]
56. Laflamme M, Boutin A, Fergusson DA, Desjardin P, Moore L, Lauzier F, Lamontagne F, Haghbayan H, Lacroix J, Shemilt M, Zarychanski R, Turgeon AF. Red Blood Cell Transfusion in Acute Cerebral Injuries: a Systematic Review of Preclinical Studies. European Society of Intensive Care Medicine, Barcelona, Spain. September 2014. [Poster Presentation]
55. Ashcroft RC, Ahsan W, Zarychanski R, Kumar A. Time to thrombolysis and anticoagulation in pulmonary embolism: A quality improvement study. Resident Research Day, University of Manitoba, Winnipeg, MB, May 2014. [Poster]
54. Zawadski D, Houston DS, Rimmer E, Zarychanski R. (senior author/supervisor). Coronary bypass surgery in a patient with hemophilia A: The critical role of the nurse clinician. World Hemophilia Congress. Melbourne, Australia. May 2014 [Poster].
53. Abou-Setta AM, Lix L, Klassen T, Zarychanski R. (senior author/supervisor). Author bias can underestimate objective outcome measures in meta-analysis: An exploratory analysis. Cochrane Canada Symposium. Ottawa, Canada. April 2014 [Oral Presentation].
52. RIMMER E, Houston BL, Cook DJ, Turgeon AF, Kumar A, Friesen C, Houston DS, Abou-Setta AM, Zarychanski R (senior author/supervisor). The efficacy and safety of therapeutic apheresis in sepsis and septic shock: A systematic review and meta-analysis. American Society of Hematology. New Orleans, U.S.A. December 2013 [Poster].
51. Wittick H, Zarychanski R, Poeppl A, Houston DS, Houston BL, Banerji V. GDF15 Is not the sole negative regulator of hepcidin in hereditary xerocytosis. American Society of Hematology. New Orleans, U.S.A. December 2013 [Poster].
50. Asselin M, Lachance Y, Lalonde G, Boutin A, Shemilt M, Lauzier F, Moore L, Zarychanski R, Archambault P, Lamontagne F, Fergusson DA, Turgeon AF. Long term functional outcome in adults with severe TBI: A meta-analysis. Canadian Critical Care Forum. Toronto, Canada, November 2013 [Poster].
Ryan Zarychanski
49. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Schemilt M, Moore L, Zarychanski R, Fergusson DA, Turgeon AF. Prognostic Value of Magnetic Resonance Imaging in Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Canadian Critical Care Forum. Toronto, Canada, November 2013 [Poster].
48. Laflamme M, Boutin, A, Haghbayan H, Shemilt M, Lauzier F, Moore L, Zarychanski R, Lacroix J, Lamontagne F, Fergusson DA, Desjardins P, Turgeon AF. Red Blood Cell Transfusion in Acute Cerebral Injuries: a Systematic Review of Preclinical Studies. Canadian Critical Care Forum. Toronto, Canada, November 2013 [Poster].
47. Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, English S, Zarychanski R, McIntyre L, Lacroix J, Griesdale D, Fergusson DA, Desjardins P, Turgeon AF. Red blood cell transfusion in patients with traumatic brain injury: a systematic review. Canadian Critical Care Forum. Toronto, Canada, November 2013 [Poster].
46. MOONEY O, Bell D, Rimmer E, Houston DS, Zarychanski R (senior author/supervisor). Nucleated red blood cells as an independent predictor of ICU mortality and ICU recidivism. Resident Research Day, University of Manitoba, Winnipeg, MB, 2013. [Oral Presentation]
45. AZAD MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou- Setta AM, Zarychanski R (senior author/supervisor). Probiotic Supplementation During Pregnancy or Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis. Canadian Society of Allergy and Clinical Immunology. Toronto, Canada, October 2013 [Poster].
44. FEDOROW CA, Pikaluk DR, Abou-Setta AM, Grocott HP, Zarychanski R (senior author/supervisor). Fibrinogen concentrate for perioperative bleeding: A systematic review and meta-analysis. CancerCare Research Day, Winnipeg, MB, May 2013. [Oral Presentation]
43. YAMAMOTO J, Dostmohamed H, Schacter I, Katz P, Zarychanski R (senior author/supervisor). Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced thyrotoxicosis: A case report. CancerCare Research Day, Winnipeg, MB, 2013. [Poster]
42. Asselin M, Lachance Y, Lalonde G, Boutin A, 3Shemilt M, Moore L, Lauzier F, Zarychanski R, Archambault P, Lamontagne F, Fergusson DA, Turgeon A. Long-term functional outcome in adults with severe TBI: a meta-analysis. International Symposium on Intensive Care Medicine, Brussels, Belgium, March 2013. [Poster]
41. Kumar K, Hiebert B, Zarychanski R, Grocott HP, Bell DD, Menkis AH, Arora RC. What is the cost of better care for patients post-cardiac surgery? 24/7 in-house consultant staffing is a cost- effective model. Canadian Cardiovascular Congress, Toronto, Ontario. October 2012 [Poster]
40. Lauzier F, Arnold D, Rabbat C, Heels-Ansdell D, Zarychanski R, Lopes R, Zytaruk N, Crowther M, Cook DJ. Major Bleeding Epidemiology and Impact on Mortality in Medical-Surgical Critically Ill Patients Receiving Thromboprophylaxis: A Cohort Study. Society of Critical Care Medicine, San Juan, Puerto Rico, 2012. [Poster]
Ryan Zarychanski
39. Hallet J, Lauzier F, Olivier M, Trottier V, Archambault P, Zarychanski R, Turgeon AF. The liberal use of platelet transfusions in the acute phase of trauma resuscitation: A systematic review. Canadian Surgery Forum. Calgary, AB, September 2012. [Poster].
38. MAKAR B, Weldon E, Lane D, Muirhead B, Doucette S, Webb A, Peters H, Strome T, Turgeon A, Rimmer E, Fergusson DA, Kumar A, Houston DS, Zarychanski R (senior author/supervisor). Hemostatic monitoring and maintenance of minimal hemostatic thresholds in massive transfusion. CancerCare Research Day, Winnipeg, MB, May 2012. [Oral Presentation]
37. HOUSTON BL, Zarychanski R, Houston DS, Schultz V, Maksimova Y, Smith B, Rinehart J, Gallagher PG (senior author/supervisor). Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. CancerCare Research Day, Winnipeg, MB, May 2012. [Oral Presentation]
36. HOUSTON BL, Abou-Setta A, Turgeon AF, McIntyre LA, Fergusson D, Zarychanski R (senior author/supervisor). Mortality and renal outcomes associated with hydroxyethyl starch resuscitation in critically ill patients: A systematic review and meta-analysis of randomized trials. CancerCare Research Day, Winnipeg, MB, May 2012. [Poster]
35. RIMMER E, Zarychanski R, Roland K, Houston D (senior author/supervisor). Adequacy of Bone Marrow Trephine Biopsy in a tertiary care centre. CancerCare Research Day, Winnipeg, MB, May 2012. [Poster]
34. Turgeon AF, Lauzier F, Boutin A, Côte N, Zarychanski R, Fowler R, Scales D, Meade M, Burns K, Bernard F, Zygun D, Moore L, Fergusson DA. Potential association of gender with mortality and withdrawal of life-sustaining therapies in patients with severe TBI: a Canadian multicentre cohort study. European Society of Intensive Care Medicine. Lisbon, September 2012. [Poster]
33. Zarychanski R, Lauzier F, Turgeon A, Marshall J, Nates J, Cox M, Arabi Y, Qushmaq I, Zytaruk N, Cook D. VTE Risk Factors in Medical-Surgical ICU Patients. Society of Critical Care Medicine, Houston, TX, 2012. [Poster]
32. Zarychanski R, Lim W, Rocha M, McIntyre L, Lamontagne F, Dodek P, Pai M, Cooper D, Alhashemi J, Zytaruk N. Do Statins Influence DVT Risk in the Critically Ill Patients? Society of Critical Care Medicine, Houston, TX, 2012. [Poster]
31. MAKAR B, Weldon E, Webb A, Peters H, Turgeon A, Houston D, Rimmer E, Kumar A, Fergusson D, Zarychanski R (senior author/supervisor). Frozen plasma to red blood cell ratio and mortality in patients requiring massive transfusion. Society of Critical Care Medicine, Houston, TX, 2012. [Poster]
30. RIMMER E, Kumar A, Turgeon A, Makar B, Houston D, Zarychanski R (senior author/supervisor). Clinical Use of Activated Protein C in Septic Shock: Results from a Multinational Cohort. Society of Critical Care Medicine, Houston, TX, 2012. [Poster]
Ryan Zarychanski
29. RIMMER E, Kumar A, Houston D, Doucette S, Zarychanski R (senior author/supervisor). Activated Protein C and Septic Shock: A Propensity-Matched Cohort Study. Society of Critical Care Medicine, Houston, TX, 2012. [Oral Presentation]
28. Zhang L, Hiebert B, Zarychanski R, Arora R. The Complex Relationship Between Preoperative Hemoglobin And The Risks Of Cardiac Surgery: An Age- And Gender-Based Analysis. Society of Thoracic Surgeons, Fort Lauderdale, FL, January 2012. [Oral Presentation]
27. HOUSTON BL, Zelinski T, Houston DS, Israels SJ, Coghlan G, Chodirker BN, Gallagher P, Zarychanski R (senior author/supervisor). Genetic Linkage of the Dehydrated Hereditary Stomatocytosis Locus to Chromosome 16 in Two Kindreds and Refinement of the Candidate Gene Region to 16q24.2 – 16qter. American Society of Hematology Annual Meeting, San Diego, CA, December 2011. [Poster]
26. Desjardins, P, English S, Zarychanski R, Lauzier F, Fergusson DA, Lacroix, J, Moore L, McIntyre LA, Turgeon AF. Effects of hemoglobin levels and transfusions on clinical outcomes of neurocritical care patients: a systematic review of comparative studies. Neuorcritical Care Society, Montreal, QC, 2011. [Poster]
25. MAKAR B, Weldon E, Lane D, Muirhead B, Turgeon A, Strome T, Webb A, Peters H, Zarychanski R (senior author/supervisor). Practice Patterns in Massively Transfused Patients. Faculty of Medicine Resident Research Day, Winnipeg, MB, January 2011. [Oral Presentation]
24. DESAUTELS A, Kirkpatrick I, Szwajcer D, Williams G, Zarychanski R (senior author/supervisor). Diagnosis of acute promyelocytic leukemia in the absence of peripheral hematologic abnormalities. Internal Medicine Research Day, Winnipeg, MB, 2011. [Poster]
23. PAUL JT, Rimmer E, Lamba K, Morales C, Zarychanski R (senior author/supervisor). Adverse events associated with bone marrow biopsy in a resident training program: First do no harm. Internal Medicine Research Day, Winnipeg, MB, 2011. [Poster]
22. SAEED M, Rubinger M, Ahsanuddin A, Morales C, Penner B, Robinson D, Zarychanski R (senior author/supervisor). Hodgkin Lymphoma associated with Evan’s syndrome, pure red cell aplasia and systematic inflammatory response. CancerCare Research Day, Winnipeg, MB, 2011. [Poster]
21. CUDMORE JA, Seftel MD, Sisler JJ, Zarychanski R (senior author/supervisor). First do no harm: Trimethoprim/sulfamethoxazole induced pancytopenia and mucositis in a patient on long term, low dose methotrexate. CancerCare Research Day, Winnipeg, MB, 2011. [Poster]
20. RIMMER E, Kumar A, Doucette S, Zarychanski R (senior author/supervisor), and The Co- operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Activated protein C and septic shock. A propensity matched cohort study. CancerCare Research Day, Winnipeg, MB, 2011. [Oral Presentation]
Ryan Zarychanski
19. HOUSTON BL, Zelinski T, Israels SJ, Coghlan G, Chodirker BN, Houston DS, Zarychanski R (senior author/supervisor). Phenotypic and genotypic evaluation of a family with hemolytic anemia. CancerCare Research Day, Winnipeg, MB, May 2011. [Oral Presentation]
18. Heels-Ansdell D, Zytaruk N, Meade M, Mehta S, Hall R, Zarychanski R, Rocha M, Lim W, Lamontagne F, McIntyre L, Dodek P, Vallance S, Davies A, Cooper J, Cook DJ for the PROTECT Investigators, CCCTG and ANZICS CTG. Pulmonary Embolism In Medical-Surgical ICU Patients. International Symposium of Intensive Care and Emergency Medicine, Brussels, Belgium, March 2011. [Poster]
17. Jung J, Fowler R, Long J, Zarychanski R, Rodin R, Cook D, Jouvet P, Marshall J, Kumar A, On behalf of the ICU-Flu Investigators. 2009-2010 H1N1-Related Critical Illness among Aboriginal and Non-Aboriginal Canadians. American Thoracic Society, Denver, CO, May 2011. Am J Resp Crit Care Med 2011;16731:B49 [Poster]
16. HOUSTON BL, Houston DS, Israels SJ, Coghlan G, Chodirker BN, Zelinski T, Zarychanski R (senior author/supervisor). Phenotypic evaluation of a family cohort with haemolytic anaemia. American Society of Hematology, Orlando, FL, 2010. [Poster]
15. KUMAR K, Gulati H, Hiebert B, Zarychanski R, Grocott H, Jacobsohn E, MacKenzie S, Zivot J, Menkis A, Arora R. The Hybrid cardiac surgical ICU: The impact of daytime cardiac anesthesiologist & 24-hour in-house intensivist staffing on outcomes after ultra-fast-track cardiac anesthesia. Society of Cardiovascular Anesthesiology, New Orleans, LA, April 2010. [Poster]
14. McIntyre LA, Turgeon A, Green R, Fox Robichaud AE, Fergusson D, Tinmouth A, Cook DJ, Hébert PC, Marshall J, Finfer S, Bagshaw S, Zarychanski R, Pagliarello J, Stiell I, Worster A, Rowe B, Emond M, Rankin N for the Canadian Critical Care Trials Group. The PRECISE fluid resuscitation pilot randomized controlled trial: Study design and preliminary feasibility results. American Thoracic Society, New Orleans, LA. May 2010. [Poster]
13. Zarychanski R, Turgeon AF, Hébert PC, Cook DJ, Tinmouth A, Kumar A, McIntyre LA, Fergusson DA. The use of anticoagulants in severe sepsis and septic shock: A national survey of critical care physicians. Society of Critical Care Medicine, Miami, FL, 2010. [Poster]
12. Turgeon AF, Lauzier F, Burns K, Zarychanski R, Meade MO, McIntryre LA, Zygun DA, Kanji S, Moore L, Fergusson DA. Determining neurological prognosis in ICU patients with severe traumatic brain injury: A survey of Canadian neurosurgeons. Society of Critical Care Medicine, Miami, FL, 2010. [Poster]
11. Mercier E, Turgeon AF, Simard JF, Lauzier F, Zarychanski R, Moore L, Nadeau L, Fergusson DA. Predictive value of S-100ß protein for prognosis in patients with moderate and severe TBI : A systematic review and meta-analysis. Society of Critical Care Medicine, Miami, FL, 2010. [Poster]
10. KUMAR K, Hiebert B, Zarychanski R, Bell D, Singal R, Manji R, Zivot J, Menkis A, Arora RC , on behalf of the Cardiovascular Health Research in Manitoba Investigator Group (CHaRM) Investigator Group. Does the use of twenty-four hour, in-house intensivist staffing model in a Ryan Zarychanski
dedicated cardiac intensive care unit impact outcomes for prolonged stay (>48 hours) patients? Society of Critical Care Medicine, Miami, FL, U.S.A., 2010. [Oral Presentation]
9. Southon J, Zytaruk N, Lim WP, Zarychanski R, Rocha M, D Heels-Ansdell, G Guyatt, Cook D, S Walter, for the PROTECT Investigators (clinicaltrials.gov NCT00182143) & Canadian Critical Care Trials Group. Venous thrombosis adjudication for a thromboprophylaxis trial. Hamilton Research Day, Hamilton, ON, 2009. [Poster]
8. Zarychanski R, Turgeon AF, Fergusson DA, Cook DJ, Hébert PC, Bagshaw SM, Monsour D, McIntyre. Renal outcomes following hydroxyethyl starch resuscitation: A meta-analysis of randomized trials. European Society of Intensive Care Medicine, Lisbon, Portugal, September 2008. [Oral Presentation]
7. Turgeon A, Lauzier F, Burns K, Fergusson D, Meade M, Zygun D, Scales D, Zarychanski R, Moore L, Kanji S, McIntyre L, Pagliarello J, Hébert P, the Canadian Critical Care Trials Group. Determining neurological prognosis in patients with severe traumatic brain injury: a survey of Canadian intensivists. International Symposium on Intensive Care Medicine, Brussels, Belgium, March 2008. [Poster]
6. Arora RC, Zarychanski R, Bell D, Zivot J, Lee J, Kumar K, Zhang L, Menkis A. The Manitoba model of post-operative cardiac surgery intensive care. Toronto Critical Care Medicine Symposium, Toronto, ON, April 2007. [Oral Presentation]
5. KUMAR K, Zhang L, Zarychanski R, Bell D, Lee J, Menkis A, Arora RC. Dedicated cardiac surgery intensive care unit: 24 hour in-house intensivists and transfusion practices. American College of Surgeons Manitoba Chapter Meeting. Winnipeg, MB, 2007. [Oral Presentation]
4. Zarychanski R, Turgeon A, Fergusson DA, Hébert PC. The use of erythropoietin in critically ill patients. A meta-analysis of published trials. Toronto Critical Care Medicine Symposium. Toronto, ON, 2007. [Oral Presentation]
3. Zarychanski R, Gulati H, Roberts D, Houston DH, Kumar A. Systemically administered heparin is associated with increased survival in patients diagnosed with septic shock. Toronto Critical Care Medicine Symposium, Toronto, ON, 2005. [Oral Presentation]
2. Zarychanski R, Elphee E, Walton P, Johnston J. Osteonecrosis of the jaw associated with pamidronate therapy. American Society of Hematology, San Diego, CA, December 2004. [Poster]
1. Zarychanski R, Houston DS. Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability. American Society of Hematology, San Diego, CA, December 2003. [Poster]
Ryan Zarychanski
RESEARCH ACTIVITIES
MAJOR RESEARCH PROGRAM:
Efficacy and Safety of Unfractionated Heparin in Septic Shock Observational study – manuscript published Meta-analysis – manuscript published National survey – manuscript in preparation Pilot randomized controlled trial – manuscript in preparation International RCT – Began February 2018
LOCAL PI AND EXECUTIVE STEERING COMMITTEES
2009-PRESENT Tranexamic Acid during Cystectomy Trial (TACT) PIs: Rodney H. Breau, Ilias Cagiannos, Franco Momoli. Role: Executive Steering Committee Member Status: Multicentre clinical trial enrolling
2009-PRESENT Prognosis in Traumatic Brain Injury PI – Alexis Turgeon Role: Executive Steering Committee Member and Site PI Status: Multicentre clinical trial enrolling
2009-2015 (ABLE) Age of Blood Evaluation Study. PIs: Jacques Lacroix, Dean Fergusson, and Alan Tinmouth Role: Site PI Status: Completed (SBGH and HSC)
2009-2015 (SOME) Screening for Occult Malignancy in Patients with Idiopathic Venous Thromboembolism: an Open Randomized Controlled Trial using Comprehensive Abdomen/Pelvis Computed Tomography. PI – Marc Carrier Role: Executive Steering Committee member and site PI Status – Completed (SBGH)
2010-2011 (PUCS): Plasma Utilization in Cardiac Surgery A Multicentre Observational Study PI - Alan Tinmouth Role: Executive Steering Committee member and local site PI. Status: Completed
2010-2013 (WAVE) Weaning and Variability Evaluation. PI – Andrew Seely Role: Executive Steering Committee member and local site PI Status: Completed
Ryan Zarychanski
2008 – 2009 (PRECISE pilot) Five Percent Albumin Vs Normal Saline as Fluid Resuscitation Strategies for the Management of Early Suspected Septic Shock. PI – Lauralyn McIntyre Role: Local site PI. Status: Completed
Data Safety and Monitoring Committees
2008 – 2012 (REDOXS) Reducing Deaths Due to Oxidative Stress: A randomized trial of glutamine and anti-oxidant supplementation in critically ill patients. PI – Darren Heyland Role: DSMB Member Status: Published
Adjudication Committees
2008 – 2010 (PROTECT) Prophylaxis of Thromboembolism in Critical Care Trial. PI – Deborah Cook Role: Outcomes Adjudication Committee member Status: Study completed/published in New England Journal of Medicine
Other Research Programs (PI or supervising investigator)
2018 – Present Evaluating the Efficacy and Safety of Tranexamic Acid in major non-cardiac surgical procedures. PIs – Brett Houston and Ryan Zarychanski (Supervisor) Study #1 (Identifying high risk surgeries) – in progress Study #2 (Evaluating current use of tranexamic acid) – in progress Study #3 (Systematic Review & Meta-analysis) – in progress Study #4 (Validation of electronic transfusion variables) – to be planned Study #5 (RCT) – to be planned Studies 1-4 will be completed by Brett Houston as part of her PhD thesis
2015 – Present IVIG in Septic Shock PIs – Murdoch Leeies and Ryan Zarychanski (Supervisor) Status – Study #1 (International Survey) – in progress Study #2 (Observational analysis) – in progress Study #3 (cost utility analysis of IVIG) planned Study #4 (pilot RCT) planned Studies 1&2 will be completed by Murdoch Leeies as part of his Master’s thesis
2010 – Present Processes of Care in Massive Transfusion PIs – Ryan Zarychanski and Bryce Makar Ryan Zarychanski
Status – Manuscript #1(systematic review FP:RBC ratios) published Manuscript #2 (implementation strategy) under development Manuscript #3 (post implementation outcomes) – under development
2013 – Present Evaluating White blood cell trajectories in patients with septic shock PIs – Emily Rimmer and Ryan Zarychanski (Supervisor) This research using a novel (to health sciences) statistical approach to evaluating clinical course and patient prognosis over time.
2010 – 2013 Bicycle Head Injuries and Helmet Legislation in Canada: Translation knowledge into action PIs – Jessica Dennis and Ryan Zarychanski (Supervisor) Status – Manuscript #1 (helmet legislation and bike ridership) published. Manuscript #2 (helmet legislation and head injuries) published
2010 – 2012 Phenotypic and genotypic evaluation of a Manitoban kindred with hemolytic anemia PI – Ryan Zarychanski Co-investigators: Brett Houston, Donald Houston, Sara Israels, Terry Zelinski, Bernie Chodirker Status – Manuscript #1 (DNA linkage analysis) published Manuscript #2 (Gene mutation discover) published
RESEARCH PRESENTATION JUDGING/MODERATING (CCV - ORGANIZATIONAL REVIEW ACTIVITIES)
2017 BSc. (Med) research dissertations, University of Manitoba 2016 BSc. (Med) research dissertations, University of Manitoba 2016 Internal Medicine Resident Research Day, University of Calgary 2013 BSc. (Med) research dissertations, University of Manitoba 2012 Internal Medicine Resident Research Day, University of Manitoba 2012 Research Day, CancerCare Manitoba
Ryan Zarychanski
TEACHING
2013- PRESENT Course Director & Instructor • Course Title: Systematic Reviews & Meta-analysis • University of Manitoba, Graduate course (Department of Community Health Sciences) • Winter Term, University of Manitoba. 3 Credit hours.
2013- PRESENT Blood Day for Health Professionals (Manitoba, Canada) Conference Developer and Chair • To educate, and build relationships between the hematologist, primary care and other specialists, and to disseminate new and existing knowledge, I developed and chaired the first annual “Blood Day” for Health Professionals in the Province of Manitoba.
2009-PRESENT Consultant Haematologist and Critical Care Physician • Weekly teaching/supervising students, residents and fellows in an outpatient hematology clinic • Teaching students, residents and fellows on the hematology consult service and on critical care rounds • Tutorial leader and laboratory facilitator for medical students (hematology and critical care) • Lecturer – resident and fellow academic half days • Tutorial leader and laboratory facilitator for medical students (haematology course and critical care tutorials) • Introduction to Clerkship tutor: Tutor for year II and III medical students
2009-PRESENT Community Health Sciences (CHS) • Tutorial leader – Population health course • Expert Resource – Medical Student – Community Health Project
2011/2012 • Tutor: Problem Based Learning. Blocks 1, 2 and 3 Year 1, undergraduate medical curriculum. University of Manitoba
2009-2011 Hematology Course Director: Physician Assistant Education Programme, University of Manitoba
2007-2008 Tutorial Leader – Evidence-based medicine workshops (University of Ottawa) Supervisor – Undergraduate summer studentship
2003-2007 Introduction to Clerkship Tutor – Undergraduate Medical Programme Mini-Hospital Tutor - Undergraduate Medical Programme Tutorial Leader – Undergraduate Medical Programme (Haematology block and Critical Care topics) Ryan Zarychanski
Lecturer – Internal Medicine academic half days
1995-1998 BCLS Instructor - Heart and Stroke Foundation of Ontario • Offered regular courses educating both medical practitioners (including medical students & nurses) and the general public
1994-1995 Teaching Assistant - University of Manitoba, Department of Chemistry • Facilitated labs for two introductory chemistry courses
Ryan Zarychanski
INVITED SPEAKING ENGAGEMENTS [CCV PRESENTATIONS]
LOCAL/ PROVINCIAL
Anticoagulation and reversal of bleeding. Academic half day. Gastrointestinal Residency Program. Rady Faculty of Health Sciences, University of Manitoba. November 28, 2019 (Winnipeg, Manitoba).
Leading Change: Evidence to Inform Decision Making and the determinants of systems change. Academic Health Sciences Leadership Program. University of Manitoba / Centre for Healthcare Innovation. November 20, 2019. (Winnipeg, Manitoba).
Looking Forward to the Present: Incorporating Innovative Trial Methods and Practices to Inform Best Practice. Centre for Healthcare Innovation Grand Rounds. Rady Faculty of Health Sciences, University of Manitoba and Shared Health Manitoba. October 1, 2019. (Winnipeg, Canada).
From programs to publication and beyond: Planning, conducting, and disseminating research to inform best practice. Clinician Investigator Program. University of Manitoba. Rady Faculty of Health Sciences. June 5, 2019. (Winnipeg, Manitoba). Co-presenter(s): Brett Houston.
Update in diagnosis and management of venous thromboembolism. Brandon Primary Care Spring Conference. University of Manitoba, Rady Faculty of Health Sciences. May 11, 2019. Elkhorn Resort & Conference Centre (Onanole, Manitoba).
An update in hemostasis. Department of Medical Oncology and Hematology Grand Rounds, CancerCare Manitoba; Section of Hematology/Medical Oncology, University of Manitoba. February 19, 2019. (Winnipeg, Manitoba).
Leading Change: Evidence to Inform Decision Making and the determinants of systems change. Academic Health Sciences Leadership Program. University of Manitoba / Centre for Healthcare Innovation. November 21, 2018. (Winnipeg, Manitoba).
Walking a thin line: The use of anticoagulants in cancer. Provincial CancerCare Conference. CancerCare Manitoba. September 21, 2018. (Winnipeg, Canada)
Evidence informed strategies to prescribe iron and B12 supplements to treat or prevent anemia. Blood Disorders Day. May 4, 2018. (Winnipeg, Canada).
Red cell transfusion triggers in critical illness. Critical Care academic half-day. University of Manitoba. April 19, 2018. (Winnipeg, Manitoba)
A practical approach to thrombocytopenia in critically ill patients. Critical Care academic half- day. University of Manitoba. April 19, 2018. (Winnipeg, Manitoba)
Ryan Zarychanski
Massive Transfusion: Improving processes of care and clinical outcomes through systems change. Manitoba Association for Medical Laboratory Science, 2018 Spring Fling. March 17th, 2018. (Winnipeg, Manitoba).
The HALO (Heparin anticoagulation to improve outcomes in septic shock), HEMOTION (Hemoglobin transfusion threshold in traumatic brain injury), and SAHARA (Aneurysmal subarachnoid hemorrhage: Red blood cell transfusion and outcome) trials: An update of ongoing investigator led trials enrolling in Winnipeg. Research In Progress (RIP) rounds, Section of Critical Care, University of Manitoba. February 22, 2018. (Winnipeg, Manitoba).
The ABCs of the CBC; How you can work up undifferentiated anemia. Family Medicine resident training program. Rady Faculty of Health Sciences, Max Rady College of Medicine. University of Manitoba. February 27, 2018. (Winnipeg, Manitoba).
A transformative vision toward the organize and use of data in Manitoba: Integrating clinical data systems to improve the capacity, performance, and value of Manitoba’s healthcare system. Rady Faculty of Health Science’s Complex Data in Health Research Workshop. University of Manitoba. February 1, 2018. (Winnipeg, Manitoba).
Massive Transfusion: Leveraging the platforms and resources of the Centre for Healthcare Innovation to create systems change and improve patient outcomes. Centre for Healthcare Innovation Grand Rounds. University of Manitoba/Winnipeg Regional Health Authority. January 31, 2018 (Winnipeg, Manitoba).
Evaluating thrombocytopenia in the Intensive Care Unit. Grand Rounds. Department of Medical Oncology and Hematology, CancerCare Manitoba; Section of Hematology/Medical Oncology, University of Manitoba. Winnipeg, Manitoba. January 30, 2018.
Leading Change: Evidence to Inform Decision Making and the determinants of systems change. Academic Health Sciences Leadership Program. University of Manitoba / Centre for Healthcare Innovation. January 16, 2018. (Winnipeg, Manitoba).
Massive Transfusion: Improving processes of care and clinical outcomes through systems change. University of Manitoba, Department of Internal Medicine Grand Rounds. November 14, 2017 (Winnipeg, Manitoba).
All bleeding eventually stops: Outcomes associated with the implementation of a Massive Transfusion Protocol at the Health Sciences Centre. Abdominal Trauma: The Gut-wrenching Truth. Surgical Intensive Care Trauma Day. November 3, 2015. Canad Inns Club Regent Casino Hotel. (Winnipeg, Manitoba).
Massive Transfusion: Improving processes of care and clinical outcomes through systems change. Blood Day. Best Blood Manitoba. November 1, 2017. (Winnipeg, Manitoba).
HALO – Heparin anticoagulation to improve outcomes in septic shock: The programmatic and international repurposing of an inexpensive and widely available compound to increase survival of patients with severe infection. University of Manitoba, Rady Ryan Zarychanski
Faculty of Health Sciences, College of Pharmacy, Seminar Series. October 25, 2017 (Winnipeg, Manitoba).
Unravelling the mysteries of sepsis: Could the answers be in the blood? The 21th Annual Bug Day. University of Manitoba. October 17, 2017. (Winnipeg, Manitoba).
Reversing oral anticoagulants: Neuroscience Rounds. University of Manitoba. March 10, 2017. (Winnipeg, Manitoba).
Options are many…the struggle is real. Evidence-informed strategies to prescribe iron and B12 supplements to treat or prevent anemia. The MEDS Conference 2017 (Medications, Evidence & Decision Support). University of Manitoba. February 11, 2017. (Winnipeg, Manitoba).
Leading Change: Using Evidence to Inform Decision Making. Academic Health Sciences Leadership Program. University of Manitoba / Centre for Healthcare Innovation. November 16, 2016. (Winnipeg, Manitoba).
Your career as a clinician-scientist: Improving patient outcomes through research while caring for patients and their families. Med 1 Career Fair. University of Manitoba. November 4, 2016. (Winnipeg, Manitoba).
Diagnosis and Management of venous thromboembolism. Nurse Practitioners association of Manitoba. (NPAM). October 21, 2016. (Winnipeg, Manitoba).
Treatment of atrial fibrillation and venous thromboembolism: A Perspective from a Haematologist. Continuing Medical Education event for primary health care practitioners. September 13, 2016 (Winnipeg, Manitoba)
ABCs of the CBC: How to make awesome hematologic diagnoses using information at your finger tips? Blood day for Health Professionals. June 17, 2016 (Winnipeg, Manitoba). [Keynote address]; with Donald S Houston.
How I use and reverse novel oral anticoagulants? Blood day for Health Professionals. June 17, 2016 (Winnipeg, Manitoba).
Using Evidence to inform decision making: Knowledge synthesis, systematic reviews and Meta- analysis. Clinical Investigator Program. University of Manitoba. June 8, 2016 (Winnipeg, Manitoba).
Reversing Novel Oral Anticoagulants: Has the cavalry arrived? University of Manitoba, Department of Internal Medicine Grand Rounds. June 7, 2016 (Winnipeg, Manitoba).
A vision to create a data warehouse in Manitoba. Real World Evidence Panel Session- "How" - How do we capture the opportunity that exists here? Real-World Evidence Forum: Let's Talk Manitoba. Life Science Association of Manitoba. Winnipeg, Manitoba. May 17 , 2016.
Ryan Zarychanski
Challenging conventions in medicine: How to develop a successful career as a clinician scientist. Invited faculty and judge. Internal Medicine Resident Research Day. University of Calgary. April 27, 2016
Finding Answers: Using evidence to inform everyday clinical questions. Manitoba College of Family Physicians, 58th Annual Scientific Assembly. April 14, 2016. (Winnipeg, Manitoba). [Keynote address].
My career as a clinician scientist: Internal Medicine Interest Group. University of Manitoba, Department of Internal Medicine. December 10, 2015 (Winnipeg, Manitoba).
Red cell transfusion in acute care medicine: Are we too liberal or to miserly? Department of Hematology and Medical Oncology Grand Rounds, CancerCare Manitoba, December 1, 2015 (Winnipeg Manitoba).
Leading Change: Using Evidence to Inform Decision Making. Academic Health Sciences Leadership Program. University of Manitoba / Centre for Healthcare Innovation. November 4, 2015. (Winnipeg, Manitoba).
Diagnosing and managing venous thromboembolism (VTE) in the emergency room. CPD Medicine, Topics in ER and Hospitalist Care. University of Manitoba. October 9, 2015. (Winnipeg, Manitoba).
Sepsis: What doesn’t kill you might not make you stronger. The 19th Annual Bug Day. University of Manitoba. October 20, 2015. (Winnipeg, Manitoba).
Systematic Reviews and meta-analysis to inform research agendas, policy and clinical decision- making. Guest Lecture: Science and practice of knowledge translation in health sciences. CHS7400; University of Manitoba. October 1, 2015. (Winnipeg, Manitoba).
Generating and using summary evidence to inform decision making. Clinical Investigator Program. University of Manitoba September 24, 2015. (Winnipeg, Manitoba).
Massive Transfusion Protocol: Creating complex systems change through implementation of a massive transfusion protocol at a tertiary health centre. 2015 Health Innovation Conference, September 15, 2015 (Winnipeg, Manitoba).
It’s your duty to be bold: Challenging conventions in medicine. 2015 Joe Doupe Memorial Lecture. University of Manitoba. September 3, 2015. (Winnipeg, Manitoba).
How you can change a system: Using severe bleeding as a platform to create complex system change and sustainably improve care. University of Manitoba, Department of Internal Medicine Grand Rounds. June 2, 2015 (Winnipeg, Manitoba).
How I work up undifferentiated anemia: Blood day for Primary Care. February 6, 2015 (Winnipeg, Manitoba).
Ryan Zarychanski
Evidence Informed Decision Making. Academic Health Sciences Leadership Program. Centre for Healthcare Innovation / University of Manitoba. January 21, 2015. (Winnipeg, Manitoba).
Engaging in original research as a subspecialty fellow in critical care medicine. Critical Care Residents; Academic half day. University of Manitoba. November 12, 2014. (Winnipeg, Manitoba)
Research Partnerships. CancerCare Manitoba Strategic Forum. November 7, 2014. (Winnipeg, Manitoba). Co-presented/prepared with Dr. Spencer Gibson.
Publishing graduate course work: How systematic reviews and epidemiologic assignments can be more than just homework. Applied Health Sciences seminar. November 7th, 2014. University of Manitoba (Winnipeg, Manitoba).
Crafting a strong clinical trial (RCT) application to CIHR. University of Manitoba, Office of Research Services. November 6, 2014 (Winnipeg, Manitoba).
Managing massive transfusion in the ICU: Can we improve care using a massive transfusion protocol?. Critical Care Rounds. October 2, 2014. University of Manitoba. (Winnipeg, Manitoba).
Cancer and Thrombosis. Community Cancer Care Educational Rounds. September 27, 2014. UPCON/CCMB. CancerCare Manitoba (Province of Manitoba).
Introduction of a Massive Transfusion Protocol at Health Sciences Centre. Combined Surgery, Anesthesia, Obstetrics and Gynecology Grand Rounds. September 17, 2014. University of Manitoba. (Winnipeg, Manitoba).
Introduction of a Massive Transfusion Protocol at Health Sciences Centre. Emergency Medicine Grand Rounds. September 9, 2014. University of Manitoba. (Winnipeg, Manitoba).
Use of target specific anticoagulants in atrial fibrillation and venous thromboembolism. Continuing Medical Education event for primary health care practitioners. September 20, 2014 (Winnipeg, Manitoba)
Use of target specific anticoagulants in atrial fibrillation and venous thromboembolism. Continuing Medical Education event for primary health care practitioners. September 13, 2014 (Onanole, Manitoba)
Managing Massive Transfusion in the emergency department. University of Manitoba, Department of Emergency Medicine, Academic Half Day. August 2014 (Winnipeg, Manitoba)
Use of target specific anticoagulants in the emergency department. University of Manitoba, Department of Emergency Medicine, Academic Half Day. August 2014 (Winnipeg, Manitoba)
Introduction to the massive transfusion protocol. WHRA Critical Care Program Annual Quality Improvement Symposium. May 2014 (Winnipeg, Manitoba)
Ryan Zarychanski
Implementation of a massive transfusion protocol to improve care in the WRHA: Manitoba Association for Laboratory Science. Spring Fling. April 2014 (Winnipeg, Manitoba)
New Oral Anticoagulants: Update. Winnipeg Vascular and Endovascular Symposium. April 2014 (Winnipeg, Manitoba)
Preparing for a career in Medicine. Career Day. St. Paul’s College, University of Manitoba. February 2014 (Winnipeg, Manitoba).
Crafting a strong clinical trial (RCT) application to CIHR. University of Manitoba, The Office of Research Services. January 2013 (Winnipeg, Manitoba).
The use and safety of new oral anticoagulants used in atrial fibrillation and venous thromboembolism. Boundary Trails Health Centre, December 2013 (Winkler, Manitoba).
The use of apheresis in critically ill patients. University of Manitoba, Critical Care Fellows Academic Half Day. November 2013 (Winnipeg, Manitoba).
What head injuries and helmet legislation can teach us about the performance of a colorectal cancer screening program: Using before-and-after studies to evaluate systems change. Department of Hematology and Medical Oncology Grand Rounds, CancerCare Manitoba, November 2013 (Winnipeg Manitoba).
Building research capacity in Manitoba: Knowledge synthesis and the Centre for Healthcare Innovation. University of Manitoba, Library science seminar, November 2013 (Winnipeg Manitoba).
Controversies in VTE prophylaxis. Winnipeg Regional Health Authority (WRHA), Family Medicine Program, CME update. October 2013 (Winnipeg Manitoba).
An update on use new oral anticoagulants in atrial fibrillation and venous thromboembolism. University of Manitoba, Department Surgery, Section of Vascular Surgery. October 2013 (Winnipeg, Manitoba).
DVT prophylaxis in the critically ill patient: Balancing proven efficacy and safety with pharmacokinetic concern. Winnipeg Regional Health Authority (WRHA), Critical Care Program, Practice Standards Committee. October 2013 (Winnipeg, Manitoba).
Antiphospholipid Antibody Syndrome. University of Manitoba, Department of Internal Medicine, Resident Academic Half Day. September 2013 (Winnipeg, Manitoba).
Putting evidence into Practice: The use of hydroxyethyl starch. Winnipeg Regional Health Authority (WRHA), Medical Advisory Committee (MAC). September 2013 (Winnipeg, Manitoba).
Contemporary Management of VTE in the Emergency Room. University of Manitoba, Department of Emergency Medicine. September 2013 (Winnipeg, Manitoba).
Ryan Zarychanski
Crafting a strong clinical trial (RCT) application to CIHR. University of Manitoba, Faculty of Medicine. August 2013 (Winnipeg, Manitoba).
The use of anticoagulants to modulate host inflammation in sepsis: The HALO research program. Manitoba Institute of Cell Biology. June 2013 (Winnipeg, Manitoba).
Knowledge to Action: Collating, creating, and building KT capacity within Manitoba to improve health service delivery and health outcomes. Canada Research Chair Tier 2, Public Lecture. University of Manitoba. May 2013 (Winnipeg, Manitoba).
The use of hydroxyethyl starch in cardiac surgery. University of Manitoba, Cardiac Anaesthesia Grand Rounds. May 2013 (Winnipeg, Manitoba)
Meet the Professor: My Career as a Clinician-Scientist. University of Manitoba, Internal Medicine Interest Group. December 2012. (Winnipeg, Manitoba)
Solving a 40 year Manitoban mystery: Clinical laboratory characterization and genetic causes of hereditary xerocytosis. Manitoba Association for Medical Laboratory Science Annual Congress. October 2012. (Winnipeg, Manitoba)
Solving a 40 year medical mystery: Highlighting ground breaking discoveries by clinician- scientists at CancerCare Manitoba. Presentation to the Board of CancerCare Manitoba. September 2012. (Winnipeg, Manitoba) Planning for a career as a clinician scientist. Internal Medicine Resident Annual Retreat. September 2012 (Brandon, Manitoba)
Conducting original research as a fellow: What does it take? Critical Care Fellows, Academic half day. September 2012 (Winnipeg, Manitoba)
From blood bank to bedside: Managing a massive blood transfusion. Canadian Blood Services, Annual Hospital Blood Bank Meeting. May 2012 (Winnipeg, Manitoba)
Solving a 40 year medical mystery. Discovering the cause of an inherited hemolytic disease with new gene technology. Springfield Collegiate. February 2012 (Oakbank, Manitoba)
Bringing the bench to the beside: Designing and implementing translational research programs as a clinician scientist. Manitoba Institute of Cell Biology Annual Retreat. September 30, 2011 (Gimli, Manitoba)
The use of starch solutions in clinical Medicine: Pro/Con debate. University of Manitoba, Department of Internal Medicine: Grand Rounds. September 2011 (Winnipeg, Manitoba)
From bedside to bench and beyond: A tale of gene discovery in large French Canadian kindred with inherited hereditary hemolysis. CancerCare Manitoba, Department Rounds. September 2011 (Winnipeg, Manitoba).
Ryan Zarychanski
Exercise for the prevention and treatment of cancer. Cancer Day for Primary Care. University of Manitoba, Continuing Professional Development in conjunction with UPCON. January 2011 (Winnipeg, Manitoba)
Finding new uses for old, inexpensive therapies: A research program to evaluate the use of heparin in severe infections. University of Manitoba, Department of Community Health Sciences Colloquium series. December 2010 (Winnipeg, Manitoba)
Pharmacogenetics and warfarin dosing – Expert panel participant. Symposium on the Future of Heart Health. September 2010 (Winnipeg, Manitoba)
From Blood Bank to Bedside: Managing Massive Blood Transfusion. Manitoba Congress of Medical Laboratory Sciences. October 2010 (Winnipeg, Manitoba)
All Bleeding eventually stops: A rational approach to blood transfusion in cardiac surgery. Cardiac Sciences Rounds. June 2010 (Winnipeg, Manitoba)
Approach to massive blood transfusion. Blood Day 2009. November 2009 (Winnipeg, Manitoba)
The use of unfractionated heparin in septic shock. University of Manitoba, Department of Internal Medicine: Grand Rounds. October, 2009 (Winnipeg, Manitoba)
Evidence based approach to thrombophilia testing. Uniting Primary Care and Oncology: The UPCON Network. January 2009. (Winnipeg, Manitoba)
Ryan Zarychanski
NATIONAL
International Clinical Trials: Lessons from InFACT. St. Michael’s Hospital. November 13, 2019. (Toronto, ON). Co-Speakers: Yaseen Arabi (Saudi Arabia), Bronwen Connolly (UK), Brian Cuthbertson (Ontario, Canada), Francois Lamontagne (Quebec, Canada)
Does the White Blood Cell Count Matter in Septic Shock. Canadian Critical Care Forum. November 13, 2019 (Toronto, ON)
Apheresis and IVIG in Septic Shock. Canadian Critical Care Forum. November 12, 2019 (Toronto, ON)
Hot topics in research: Using innovative clinical trial designs and novel methods of consent in health research. Canadian Perioperative Anesthesia Clinical Trials Group. June 21, 2019. (Calgary, AB).
Hematologic issues in critical care. Canadian Critical Care Society, 2019 Canadian Critical Care Review Program. June 7, 2019. (Toronto, ON).
Heparin anticoagulation in septic shock: A global effort to repurpose an old drug for a new indication. Thrombosis & Atherosclerosis Research Institute (TaARI). McMaster University. December 19, 2018. (Hamilton, Ontario).
Plasma exchange in the ICU: Sepsis and limb ischemia. Canadian apheresis Group (CAG), Annual General Meeting. November 03, 2018. (Montreal, Québec).
Hematologic issues relevant to critical care. Canadian Critical Care Society, 2018 Canadian Critical Care Review Program. June 1, 2018. (Toronto, ON).
Blood products use in intensive care: First do no harm. 2018 Symposium: Approches cliniques des coagulopathies et utilisation des produits sanguins / Clinical approaches to coagulopathy and blood products utilization. Centre de Recherche du Centre Hospitalier de l’Université de Montréal. May 13, 2018. (Montreal, Québec).
Thrombocytopenia in the intensive care unit: the past present and future. University of Ottawa, Department of Medicine Section of Hematology, Grand Rounds. April 06, 2018 (Ottawa, ON)
Integrating clinical data systems to improve the capacity, performance, and value of Manitoba’s healthcare system. Canadian Institutes of Health Research, Rewarding Success, Ideathon. February 7, 2018. (Ottawa, ON).
Assessing thrombocytopenia in the intensive care unit: the past present and future. Canadian Critical Care Forum. October 02, 2017 (Toronto, ON)
Meta-analysis for researchers: More than the sum of each part? Canadian Perioperative Anesthesia Clinical Trials. Niagara Falls, Ontario. June 22, 2017. Ryan Zarychanski
Research Training: Going away or staying home: Canadian Critical Care Trials Group – Research Career Development Day. (St. Alexis des Monts, Québec). June 12, 2017.
Alternatives to blood transfusion. Symposium. Gestion Personnalisée du sang / Patient Blood Management. Université de Montréal. Centre de Recherche du Centre Hospitalier de l’Université de Montréal. (Montreal, Québec). May 13, 2017.
Platelet dysfunction in Critical Care. Canadian Critical Care Forum. November 02, 2016 (Toronto, ON)
Apheresis in septic shock: An update and proposal for further research. Canadian Apheresis Group (CAG), Annual General Meeting. (Gatineau, Québec). September 17, 2016
Asking questions that matter. Canadian Critical Care Trials Group, Resident Research Day. June 13, 2016. (Halifax, Nova Scotia).
Red Cell Transfusion: We’re too Liberal. Canadian Critical Care Forum. October 26, 2015 (Toronto, ON)
Blood Day for Primary Care: Development of a CPD event to educate primary practitioners and standardize practice among specialists. 7th National CPD Accreditation Conference. September 29, 2015 (Ottawa, ON)
Evaluating apheresis in septic shock: The pros and cons. Canadian apheresis Group, Annual General Meeting. September 22, 2015. (Gatineau, QC)
Addressing tough clinical questions with high quality research Canadian Critical Care Trials Group, Resident Research Day. June 8, 2015. Château Montebello. (Montebello, Quebec).
Implementation of massive transfusion protocols to guide practice in severe bleeding. Canadian Association of Transfusion Medicine (CSTM) – Annual Conference. May 21, 2015 (Winnipeg, MB)
Organized chaos: How a massive transfusion protocol affects the care of severely bleeding patients. The Canadian Association of Critical Care Nurses: CACCN. February 23, 2015. (Winnipeg, Manitoba).
Heparin-Induced Thrombocytopenia. Canadian Critical Care Forum. November 1, 2014 (Toronto, ON)
Heparin – Useful but not tested. Canadian Critical Care Forum. October 30, 2014 (Toronto, ON)
How have clinical trials research impacted care for patients with septic shock. Canadian Critical Care Research Coordinator’s Workshop. October 29, 2014. (Toronto, ON)
Grantsmanship: CCCTG (Canadian Critical Care Trials Group) school seminar series. December 16, 2013 (National Skype conference). Ryan Zarychanski
Hydroxyethyl starch in the ICU. Canadian Critical Care Forum. November 2013 (Toronto, ON)
The efficacy and safety of therapeutic apheresis in patients with sepsis and septic shock: A systematic review and meta-analysis. Canadian Critical Care Forum. November 2013 (Toronto, ON)
Cardiovascular Surgery: Treatment of Postoperative Bleeding. The Canadian Critical Care Forum. November 2013 (Toronto, ON)
The use of anticoagulants to modulate host inflammation in sepsis: The HALO research program. Critical Care Section Rounds. Dalhousie University. May 2013 (Halifax, Nova Scotia).
The use of apheresis technologies in sepsis and septic shock. Canadian apheresis Group, Annual General Meeting. April 2013 (Winnipeg, MB)
Heparin anticoagulation to improve outcomes in septic shock: The HALO research program. Critical Care Section Rounds. University of Toronto/St. Michael’s Hospital. April, 2013 (Toronto, ON)
Using the medical literature to guide clinical decision making. Rocky Mountain/American College of Physicians Internal Medicine Conference. November 2012 (Banff, AB)
Implementation of massive transfusion protocols to guide practice in severe bleeding - is your institution ready? Canadian Critical Care Forum. October 2012 (Toronto, ON)
The management of massive transfusion. Canadian Critical Care Forum. November 2011 (Toronto, ON)
Use of anticoagulants to modulate host inflammation in sepsis. Canadian Critical Care Forum. November 2011 (Toronto, ON)
Supporting practice with evidence: Plasma & red cell ratios in massive transfusion. Massive Transfusion Consensus Conference. June 2011 (Toronto, ON)
The use heparin in sepsis and septic shock. Visiting Professorship. Division of Critical Care Medicine. April 2011 (McMaster University, Hamilton, ON)
A rational approach to the massive blood transfusion. Invited Lecturer to Critical Care Fellows. April 2011 (McMaster University, Hamilton, ON)
Lessons learned from the H1N1 (2009) pandemic. The Canadian Society of Hospital Pharmacists. Satellite Symposium. March 2010 (Banff, Alberta)
Clinical management of anemia in the chronic anemia and surgical setting. The Canadian Society for Transfusion Medicine. June 2009 (Ottawa, Ontario) Ryan Zarychanski
Epidemiologic unknowns in H1N1 infection. Public Health Agency of Canada. Severe H1N1 Disease: Preventing Cases, Reducing Mortality. August 2009 (Winnipeg, Manitoba)
Ryan Zarychanski
INTERNATIONAL
Heparin anticoagulation to improve outcomes in septic shock: The HALO international randomized controlled trial. Síria Hospital Do Coração – Hcor. São Paulo, Brazil. September 27, 2019.
Bridging the gap: Programs of research at the intersection of critical care and hematology. Síria Hospital Do Coração - HCor. São Paulo, Brazil. September 26, 2019
Walking a thin line: The use of heparin to modulate the host response in septic shock. Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo. São Paulo, Brazil. September 25, 2019
The use of heparin to modulate the host inflammatory and thrombotic response in septic shock. Chinese Critical Care Congress (CCCC) 2019. Chinese Society of Critical Care Medicine. Wuhan, Hubei Province, China. September 21, 2019.
The diagnosis and treatment of heparin induced thrombocytopenia (HIT) in critical care. Chinese Critical Care Congress (CCCC) 2019. Chinese Society of Critical Care Medicine. Wuhan, Hubei Province, China. September 20, 2019.
Apheresis and intravenous immunoglobin (IVIG) in septic shock. Chinese Critical Care Congress (CCCC) 2019. Chinese Society of Critical Care Medicine. Wuhan, Hubei Province, China. September 20, 2019.
Disorders of Hemostasis. North American Highlights of ASH: American Society of Hematology. Chicago, IL, U.S.A. January 18-19, 2019.
Disorders of Hemostasis. North American Highlights of ASH: American Society of Hematology. San Francisco, CA, U.S.A. January 11-12, 2019.
Drugs that cause thrombocytopenia: What’s your pneumonic? American Society of Hematology (ASH). 59th ASH-a-Palooza. Trainee Day. Reimagined. San Diego, CA, U.S.A. November 30, 2018.
A pragmatic approach to evaluate thrombocytopenia in the Intensive Care Unit: The Past, Present, and Future. Cascade – 2018; Advances in Hematostasis and Thrombosis. University of Pittsburgh School of Medicine, Center for Continuing Education. Sheraton Station Square, Pittsburgh, Pennsylvania, U.S.A. May 4, 2018.
Assessing Thrombocytopenia in the Intensive Care Unit: The Past, Present, and Future. American Society of Hematology (ASH). 59th Annual Congress, Educational Program. In Session, Thrombocytopenia in Hospitalized Patients. Atlanta, GA, U.S.A. December 9-12, 2017.
HALO (Heparin anticoagulation to improve outcomes in septic shock: A call for global collaboration. International Forum of Acute Care Trialists (InFACT). November 7, 2017. Rio de Janeiro, Brazil.
Ryan Zarychanski
Meta-Analysis: Greater than the sum of its parts? American Thoracic Society (ATS) Annual Congress. Look before you leap: Skills for critical evaluation of clinical research. Washington DC, U.S.A. May 19, 2017.
How trials of heparin in septic shock could facilitate a sustainable platform for global critical care research. International Forum of Acute Care Trialists (InFACT). February 28, 2016. Whistler, British Columbia, Canada)
Indication for therapeutic apheresis. Society of Critical Care Medicine. February 24, 2016. (Orlando, Florida, U.S.A)
Evaluating for and treating platelet dysfunction. Society of Critical Care Medicine. February 22, 2016. (Orlando, Florida, U.S.A)
Heparin: Opportunities to evaluate an inexpensive therapy to save lives in patients with life threatening infection. Association of Southeast Asian Nations - Network for Drugs, Diagnostics, Vaccines and Traditional Medicines Innovation. August 24, 2016. Manila, Philippines.
Plasmapheresis for all? 35th International Symposium on Intensive Care and Emergency Medicine. March 19, 2015 (Brussels, Belgium).
Red cell to plasma ratios. 35th International Symposium on Intensive Care and Emergency Medicine. March 19, 2015 (Brussels, Belgium).
Or simply heparin? 35th International Symposium on Intensive Care and Emergency Medicine. March 19, 2015 (Brussels, Belgium).
Framing the Question. InFACT Session: Investigator-led research: How to do it. World Federation of Societies of Critical Care Medicine Congress. August 2013 (Durban, KwaZulu-Natal, South Africa)
Association of Hydroxyethyl Starch Administration With Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation: A Systematic Review and Meta- analysis. American Thoracic Society International Conference. May 2013 (Philadelphia, Pennsylvania, U.S.A.)
Blood Management in the ICU. A Day of Critical Care: Greensboro AHEC. October 2009 (Greensboro, North Carolina, U.S.A) Ryan Zarychanski
PRESS
BROADCAST INTERVIEWS
Media interview related to the publication of “Non-nutritive sweeteners and cardio-metabolic health: A systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Canadian Medical Association Journal. 2017 Jul 17;189(28):E929-E939” CBC radio: Information Morning. July 17, 2017. (Pan-Canadian rolling interviews)
Video: The Consult Guys – VTE: Is there Cancer? Ann Intern Med. 2016;164(2):CG1. doi:10.7326/W16-0001. http://annals.org/article.aspx?articleid=2482258 In reference to: Carrier M, Lazo-Langner A, Shivakumar S, Tagalakis V, Zarychanski R, Solymoss S, Routhier N, Douketis J, Danovitch K, Lee AY, Le Gal G, Wells PS, Corsi D, Ramsay T, Coyle D, Chagnon I, Kassam Z, Tao H and Rodger MA for the SOME Investigators. Screening for occult cancer in unprovoked venous thromboembolism. New England Journal of Medicine/NEJM. 2015;373(8):697-704 PMID:26095467
Battling life-threatening infections and the HALO Program. The Heath Report. CJOB Radio. January 2013.
Media interview related to the publication of "Probiotic Supplementation During Pregnancy or Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis. British Medical Journal/BMJ. 2013;347:f6471." CJOB Radio. December 2013.
Media interview related to the publication of "Helmet Legislation and admissions to hospital for cycling related head injuries in Canadian provinces and territories: interrupted time series analysis. British Medical Journal/BMJ. 2013;346:f2674." CJOB Radio. May 2013.
Media interview related to the publication of Helmet Legislation and admissions to hospital for cycling related head injuries in Canadian provinces and territories: interrupted time series analysis. British Medical Journal/BMJ. 2013;346:f2674." CTV morning show. CTV. May 2013.
Media interview related to the publication of "Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012;120(9):1908-1915." CTV morning show. CTV. September 2012.
Media interview related to the publication of "Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012;120(9):1908-1915." This publication was featured on the cover of Blood. CTV National News. CTV. September 2012.
Media interview related to the publication of "Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012;120(9):1908-1915." Evening news. CJOB Radio. September 2012.
Ryan Zarychanski
WRITTEN PRESS / TEXT INTERVIEWS
University of Manitoba study urges caution in use of artificial sweeteners National Post. July 17, 2017. http://nationalpost.com/pmn/life-pmn/food-life-pmn/university-of-manitoba-study-urges-caution-in- use-of-artificial-sweeteners/wcm/19a04ec0-82be-4028-8e2e-eec7a60f4ba9
University of Manitoba: artificial sweeteners linked to heart disease and weight gain CTV News. July 17, 2017. http://winnipeg.ctvnews.ca/university-of-manitoba-artificial-sweeteners-linked-to-heart-disease-and- weight-gain-1.3505830
Artificial sweeteners linked to serious health issues. The Toronto Sun. http://www.torontosun.com/2017/07/18/artificial-sweeteners-linked-to-serious-health-issues-report July 18, 2017.
Top research stories of 2016: http://news.umanitoba.ca/top-research-stories-of-2016/ December 2016.
Dr. Lyonel Israels inaugural professor appointed. U of M news. http://news.umanitoba.ca/2m-in-donations-to-enhance-hematology-research-education-in-memory- of-health-innovator-dr-lyonel-israels/ March 2016.
University of Manitoba receives $2M for blood research. CBC News. http://www.cbc.ca/news/canada/manitoba/uofm-blood-research-1.3490512 March 2016
Faculty of Health Sciences CPD recognized with national awards. U of M news. http://news.umanitoba.ca/faculty-of-health-sciences-cpd-recognized-with-national-awards/ March, 2015.
What you can learn from a drop of blood. WAVE: Winnipeg Regional Health Authority Magazine. March/April 2015.
My career as a Clinician Scientist. Mediscene, University of Manitoba. December, 2014.
Iron deficiency, even mild anemia, may protect against malaria, TB and cancer. Washington Post. November 24, 2014. http://www.washingtonpost.com/national/health-science/iron- deficiency-even-mild-anemia-may-protect-against-malaria-tb-and-cancer/2014/11/24/d838bc94- 5dfa-11e4-8b9e-2ccdac31a031_story.html
Massive Transfusion Protocol Project Makes Complex System Work Better. Overhaul demands radical change and innovation; results in enormous improvements. Health Sciences Centre Focus, September 26, 2014.
Ryan Zarychanski
New Joint funding for unit to boost medical research. Winnipeg Free Press. February 2014.
Rapid Response. Massive Blood Transfusion Protocol team established at Health Sciences Centre Winnipeg, led by Dr. Ryan Zarychanski WAVE: Winnipeg Regional Health Authority Magazine. January 2014. http://www.wrha.mb.ca/wave/2014/01/files/WaveFull-1401.pdf
Solving a medical mystery. CancerCare Manitoba Annual Report. September 2013.
Not just for kids: Bike helmets should be the law for adults. The Globe and Mail. August 2013. http://www.theglobeandmail.com/globe-debate/not-just-for-kids-bike-helmets-should-be-the-law- for-adults/article13782545/
Cycling helmet laws not so clear-cut on many issues. The Globe and Mail. June 2013. http://www.theglobeandmail.com/news/national/cycling-helmet-laws-not-so-clear-cut-on-many- issues/article4366972/
More to bike safety than helmets, study finds. Bicycle lanes, safe-passing laws among factors reducing injuries. Winnipeg Free Press. May 2013.
Connecting the Dots. Dr. Ryan Zarychanski is changing the way health care is delivered throughout Manitoba – and around the world. WAVE: Winnipeg Regional Health Authority Magazine. April 2013. http://www.wrha.mb.ca/wave/2013/03/files/WaveFull-1303.pdf
Meta-analysis: Hydroxyethyl starch associated with mortality and acute kidney injury. www.pharmacy-forum.co.uk. February 2013. http://www.pharmacy-forum.co.uk/pharmacy- news/8561-meta-analysis-hydroxyethyl-starch-associated-mortality-acute-kidney-injury.html
Blood expander found problematic in local study. Says commonly used HES can cause harm. Brandon Sun. February 2013. http://www.brandonsun.com/breaking-news/blood-expander-found- problematic-in-local-study-191970971.html?thx=y
Intravenous Fluid Associated with Increased Risk of Death, AKI. www.renalbusiness.com. February 2013. http://www.renalbusiness.com/news/2013/02/intravenous-fluid-associated-with- increased-risk-of-death-kidney-injury.aspx
Intravenous Fluid Used For Critically Ill Patients Linked With Adverse Outcomes. www.redorbit.com. February 2013. http://www.redorbit.com/news/health/1112787771/intravenous- fluid-used-for-critically-ill-patients-linked-with-adverse-outcomes/
Hydroxyethyl starch not linked to favorable outcomes. www.nurse.com. February 2013. http://news.nurse.com/article/20130219/NATIONAL02/103040001/-1/frontpage#.Upzkv9JDvK0
Blood Substitute can lead to more deaths, study finds. Health Medicine Network. February 2013. http://healthmedicinet.com/i/blood-substitute-can-lead-to-more-deaths-study-finds/
Fraudulent Data May Have Led to Use of Risky Treatment in ICUs. Second look at data on a starch-filled solution finds it may do more harm than good. HealthDay News for Healthier Ryan Zarychanski
Living. February 2013. http://consumer.healthday.com/general-health-information-16/emergencies- and-first-aid-news-227/fraudulent-data-may-have-led-to-use-of-risky-treatment-in-icus-673607.html
Misconduct biased fluid resuscitation studies. News Medical. February 2013. http://www.news- medical.net/news/20130220/Misconduct-biased-fluid-resuscitation-studies.aspx
Exclusion of suspect data raises question mark over safety of common plasma substitute. British Medical Journal. February 2013. http://www.bmj.com/content/346/bmj.f1132
A common blood substitute has been found to be linked to more deaths than lives. February 2013. http://saypeople.com/2013/02/20/a-common-blood-substitute-has-been-found-to-be-linked-to- more-deaths-than-lives/#axzz2LfEPOvbn
Fresenius Blood Volumizer Linked to Deaths in Study. www.bloomberg.com. February 2013. http://www.bloomberg.com/news/2013-02-19/fresenius-blood-volumizer-linked-to-deaths-in- study.html
Hydroxyethyl Starch Has High Mortality Risk. MedPage Today. February 2013. http://www.medpagetoday.com/CriticalCare/GeneralCriticalCare/37431
Blood substitute can lead to more deaths, study finds. MSN Canada. February 2013. http://news.ca.msn.com/local/manitoba/blood-substitute-can-lead-to-more-deaths-study-finds
Fresenius Blood Volumizer Linked to Deaths in Study. Business Week. February 2013. http://www.businessweek.com/news/2013-02-19/fresenius-blood-volumizer-linked-to-deaths-in- study Author Insights: An Analysis Excluding Trials by Researcher Under Fire for Misconduct Finds Product Used for Critically Ill Patients Is Harmful. News@JAMA. February 2013. http://newsatjama.jama.com/2013/02/19/author-insights-an-analysis-excluding-trials-by-researcher- under-fire-for-misconduct-finds-product-used-for-critically-ill-patients-is-harmful/
Does scientific misconduct cause patient harm? The case of Joachim Boldt. Retraction Watch. February 2013. http://retractionwatch.com/2013/02/19/does-scientific-misconduct-cause-patient- harm-the-case-of-joachim-boldt/
Blood substitute can lead to more deaths, study finds. CBC News. February 2013. http://www.cbc.ca/news/canada/manitoba/blood-substitute-can-lead-to-more-deaths-study-finds- 1.1371991
Blood expander found problematic in local study. Says commonly used HES can cause harm. Winnipeg Free Press. February 2013. http://www.winnipegfreepress.com/local/blood-expander- found-problematic-in-local-study-191970971.html
Student Sleuth Helps Solve Blood Mystery. MB Medicine. Magazine of the University of Manitoba Faculty of Medicine, Alumni and Friends. January 2013.
Ryan Zarychanski
Meta-analysis: Hydroxyethyl starch associated with mortality and acute kidney injury. www.pharmacy-forum.co.uk. January 2013. http://www.pharmacy-forum.co.uk/pharmacy- news/8561-meta-analysis-hydroxyethyl-starch-associated-mortality-acute-kidney-injury.html
Hydroxyethyl starch riskier in acute fluid resuscitation. American College of Emergency Physicians. January 2013. http://www.acep.org/News-/Medical-News-Feeds/Top- Stories/Hydroxyethyl-starch-riskier-in-acute-fluid-resuscitation/
Media interview related to the publication of "Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012;120(9):1908-1915." Winnipeg Free Press. Article featured on the front page of the city's larger print news publication. September 2012.
Manitoba researchers solve blood disorder mystery. Winnipeg Free Press. September 2012.
Anemia may help in chronic care, MDS argue. Winnipeg Free Press. September 2012.
Helmet law needed here: prof. Winnipeg Free Press. September 2012.
Serious adverse events associated with the use of starch-containing intravenous fluids for volume expansion: an updated systematic review and meta-analysis. National Institute for Health Research, University of York Centre for Reviews and Dissemination. May 2012. http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42012002348#.UpzmltJDvK0
2011/2012 Research Highlights of Grant Recipients. Heart & Stroke Foundation of Manitoba. December 2011.
News from The George & Fay Yee Centre for Healthcare Innovation. Winnipeg Regional Health Authority Newsletter. November 2011.
Media interview related to the publication of: The Effects of Provincial Bicycle Helmet Legislation on Helmet Use and Recreational Bicycle Ridership in Canada. Injury Prevention. Dennis J, Potter B, Ramsay T, Zarychanski R. CBC News. August 2010.
Cyclists should be forced to wear helmets: study. CBC News. August 2010. http://www.cbc.ca/news/health/story/2010/08/10/
Severe H1N1 patients benefit from early care. CBC News. January 2010. http://www.cbc.ca/news/health/story/2010/01/21/h1n1
Media Interview related to the publication of: The anemia of chronic disease is not a disease and may be beneficial. Zarychanski R, Houston DS. CMAJ. 2008;179:333-337. Winnipeg Free Press. August 2008.
More cancer checks urged Colorectal cancer claims thousands. Winnipeg Free Press. September 2007.
Ryan Zarychanski
Canadians shying away from colorectal cancer screening: study. Only 17.6% of people studied reported having been tested within their recommended time frame of the previous two years. CBC News. September 2007. http://www.cbc.ca/news/technology/canadians-shying-away-from- colorectal-cancer-screening-study-1.633074
Medical residents give nod to Romanow. www.cbc.ca. November 2002. http://www.cbc.ca/news/canada/manitoba/story/2002/11/29/
Ryan Zarychanski
RECOGNITIONS/HONOURS/ACHIEVEMENTS
2019 Mentor of the Year Award. Royal College of Physicians and Surgeons of Canada. Region 2. (Ottawa, Ontario).
2017 Excellence in Research and Mentorship Award. Department of Medical Oncology and Hematology, Cancercare Manitoba (Manitoba, Canada).
2017 Doctors Manitoba Scholastic Award (Manitoba, Canada)
2017 Nominee, Med II Pre-Clerkship Teaching Award. Manitoba Medical Students Association. University of Manitoba.
2016 Lyonel G. Israels Chair in Hematology ($3,000,000 Endowment) University of Manitoba, Faculty of Health Sciences.
2015 CFPC Continuing Professional Development (CPD) Award College of Family Physicians of Canada, Ottawa, Canada. Award in recognition of “Blood Day” CPD event for Family Physicians in Manitoba & Northwestern Ontario
2015 Joe Doupe Memorial Lecture. University of Manitoba. September 3, 2015
2014 Liam J. Murphy Young Investigator Award. Department of Internal Medicine, University of Manitoba. November, 2014 ($30,000)
2013 Nomination: Mentor of the Year Royal College of Physicians & Surgeons of Canada
2012 Research Citation Award, Society of Critical Care Medicine, Annual Congress. Houston, TX, 2012.
2006-2008 University of Ottawa tuition award (for Masters degree) ($11,000)
2006 CSCI/CIHR (Canadian Institute of Health Research), Resident research award [Original Research] ($1000)
2005-2006 Chief Resident – Critical Care – University of Manitoba
2005 First Prize – Jerry Scott Day – National research competition among
Canadian haematology fellows [Original Research] ($1000)
2005 Second Prize - Internal Medicine, Resident Research Day [Original Research]
2005 Second Prize - Internal Medicine, Resident Research Day [Case Presentation] Ryan Zarychanski
2004 First Prize – Cancer Care Manitoba Research Day [Original Research]
2004 Second Prize – Internal Medicine, Resident Research Day [Original Research]
2003 CSCI/CIHR (Canadian Institute of Health Research) - Resident research award [Original Research] ($1000)
2003 First Prize – Cancer Care Manitoba Research Symposium [Original Research] ($1000)
2003 Second Prize – Internal Medicine, Resident Research Day [Original Research]
2003 Resident of the Month. (January) University of Manitoba
2000 Aesculapian Award. University of Ottawa, Faculty of Medicine
1999 Commonwealth Fund Bursary ($2000)
1998 Second Prize - Summer Student Research Forum - University of Ottawa.
1997-1998 President, Aesculapian Society
1996-1997 Executive Vice President, Aesculapian Society
1996 Curriculum Development - Faculty of Medicine - University of Ottawa -Developed and implemented a novel stage II (clerkship) medical curriculum to lessen the burden of early decision making with respect to residency training. Ryan Zarychanski
BOARD/COMMITTEE EXPERIENCES
2016- PRESENT ○ Member, Research and Faculty Development Committee, Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, University of Manitoba 2017- 2018 ○ Executive Board Member, Canadian Critical Care Trial Group 2016- PRESENT ○ Chair, Academic Committee. Section of Hematology and Medical Oncology, Department of Internal Medicine, University of Manitoba; Department of Medical Oncology and Hematology, CancerCare Manitoba (Winnipeg, Manitoba) 2015-2018 ○ Discipline Appeals Committee, Faculty of Health Sciences, College of Medicine 2015 ○ Member, Department Head Search Committee, Department of Internal Medicine, University of Manitoba (Winnipeg, Manitoba). 2015-PRESENT ○ Chair, Blood Disorders Day planning committee. (Cancercare Manitoba) 2014 ○ Member, Section Head Search Committee, Section of Haematology and Medical Oncology, Department of Internal Medicine, University of Manitoba (Winnipeg, Manitoba). 2013- PRESENT ○ Leadership committee, Centre for Healthcare Innovation. University of Manitoba/Winnipeg Regional Health Authority (Winnipeg, Manitoba) ○ Scientific Advisory Committee, Centre for Healthcare Innovation. University of Manitoba/Winnipeg Regional Health Authority (Winnipeg, Manitoba) ○ Member, Lyonel G. Israels Memorial Lecture scientific committee 2013- 2015 ○ Chair, Academic Grand Rounds, Department of Hematology and Medical Oncology, CancerCare Manitoba; Section of Hematology/Medical Oncology. University of Manitoba. (Winnipeg, Manitoba). 2011-2014 ○ Overall Project Lead: Implementation of a Massive Transfusion Protocol in The Winnipeg Regional Health Authority (Winnipeg, Manitoba) ○ B.Sc. (Medicine) Peer Review Panel (University of Manitoba) 2010-PRESENT ○ Transfusion Practice Committee: Member. Health Sciences Centre (Winnipeg, Manitoba) 2010-2012 ○ Career Planning Committee: Hematology residency: Member (Winnipeg, MB) 2010-2012 ○ Hematology, Residency Training Committee: Member (Winnipeg, MB) Responsible for coordinating research activities for hematology trainees 2005-2006 ○ Standards Committee (Critical Care, Winnipeg Regional Health Authority) o CSCI/CHIR research award selection committee, Faculty of Medicine, University of Manitoba 2003-2004 ○ Residency Training Committee (Haematology, University of Manitoba) 2003-2005 ○ Canadian ICU Collaborative, Transfusion Practices working group 2001-2003 ○ Accreditation Committee Royal College of Physicians and Surgeons of Canada ○ Chair, Contract negotiations committee, PARIM (Professional Association of Interns and Residents of Manitoba) ○ PARIM – Board and executive member – Winnipeg, Manitoba ○ CAIR board member (Canadian Association of Interns and Residents) Ryan Zarychanski
2000-2001 ○ Internal Medical Resident Training Committee, University of Manitoba 1997 ○ Faculty Council Committee, University of Ottawa 1996-1998 ○ Dean’s Advisory Board, Faculty of medicine, University of Ottawa ○ Admissions Committee, Faculty of medicine, University of Ottawa 1997-1998 President, Aesculapian Society, University of Ottawa 1996-1997 Executive Vice President, Aesculapian Society, University of Ottawa 1996 ○ Chair of the Peer Review Board, University of Ottawa ○ Dean’s Selection Committee – University of Ottawa ○ Board of Administration/Board of Directors for Student’s Federation of the University of Ottawa (SFUO)
Ryan Zarychanski, BSc, BSc (Med), MD, MSc, FRCPC