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Harnessing the Power of Precision Oncology
Cancer Advances Cleveland Clinic Cancer Center | Winter 2019 Harnessing the Power of Precision Oncology Ranked No. 5 in America for cancer care by U.S. News & World Report. Dear colleagues, Welcome to this issue of Cancer Advances. Our cover story features a sampling of our work in genetics and Advancing genomics, which is shifting the focus of questioning in oncologic research and care from tumor location to genetic mutation. Our researchers are approaching questions of cancer genetics from across the continuum, including detecting cancers at an earlier stage (p. 4), best Precision practices in testing for non-small cell lung cancer (p. 6), expanding the use of predictive assays (p. 7), treatments targeting individual tumor DNA (p. 8) and a new National Cancer Institute grant to study response prediction in Oncology radiation oncology (p. 10). Our leadership in developing the accreditation program for rectal cancer (p. 22) and the continued relevance and from Risk Prediction utility of the Khorana score (p. 14) showcase our ability to determine the line of inquiry at the national level. to Treatment Response Our multidisciplinary Sarcoma Program continues to investigate better treatments for this rare cancer while providing patients with a level of expertise matched by few centers in the United States (p. 16). Our work on potential new therapies for acute myeloid leukemia (p. 20) and breast cancer (p. 13) demonstrates the promising results of the continued pursuit of inquiry for our patients. Finally, we demonstrate our ability to ask complex questions with the work we’re pursuing on laser interstitial therapy with colleagues in the Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center (p. -
Libertarian Party National Convention | First Sitting May 22-24, 2020 Online Via Zoom
LIBERTARIAN PARTY NATIONAL CONVENTION | FIRST SITTING MAY 22-24, 2020 ONLINE VIA ZOOM CURRENT STATUS: FINAL APPROVAL DATE: 9/12/20 PREPARED BY ~~aryn ,~nn ~ar~aQ, LNC SECRETARY TABLE OF CONTENTS CONVENTION FIRST SITTING DAY 1-OPENING 3 CALL TO ORDER 3 CONVENTION OFFICIALS AND COMMITTEE CHAIRS 3 CREDENTIALS COMMITTEE REPORT 4 ADOPTION OF THE AGENDA FOR THE FIRST SITTING 7 CONVENTION FIRST SITTING DAY 1-ADJOURNMENT 16 CONVENTION FIRST SITTING DAY 2 -OPENING 16 CREDENTIALS COMMITTEE UPDATE 16 PRESIDENTIAL NOMINATION 18 PRESIDENTIAL NOMINATION QUALIFICATION TOKENS 18 PRESIDENTIAL NOMINATION SPEECHES 23 PRESIDENTIAL NOMINATION – BALLOT 1 24 PRESIDENTIAL NOMINATION – BALLOT 2 26 PRESIDENTIAL NOMINATION – BALLOT 3 28 PRESIDENTIAL NOMINATION – BALLOT 4 32 CONVENTION FIRST SITTING DAY 2 -ADJOURNMENT 33 CONVENTION FIRST SITTING DAY 3 -OPENING 33 CREDENTIALS COMMITTEE UPDATE 33 VICE-PRESIDENTIAL NOMINATION 35 VICE-PRESIDENTIAL NOMINATION QUALIFICATION TOKENS 35 VICE-PRESIDENTIAL NOMINATION SPEECHES 37 ADDRESS BY PRESIDENTIAL NOMINEE DR. JO JORGENSEN 37 VICE-PRESIDENTIAL NOMINATION – BALLOT 1 38 VICE-PRESIDENTIAL NOMINATION – BALLOT 2 39 VICE-PRESIDENTIAL NOMINATION – BALLOT 3 40 STATUS OF TAXATION 41 ADJOURNMENT TO CONVENTION SECOND SITTING 41 SPECIAL THANKS 45 Appendix A – State-by-State Detail for Election Results 46 Appendix B – Election Anomalies and Other Convention Observations 53 2020 NATIONAL CONVENTION | FIRST SITTING VIA ZOOM – FINAL Page 2 LEGEND: text to be inserted, text to be deleted, unchanged existing text. All vote results, points of order, substantive objections, and rulings will be set off by BOLD ITALICS. The LPedia article for this convention can be found at: https://lpedia.org/wiki/NationalConvention2020 Recordings for this meeting can be found at the LPedia link. -
My Name Is Michael Mark Gottesman and My Position Is Deputy Director for Intramural Research at the National Institutes of Health
NHGRI: OH_Gottesman_Michael_20111113 1 3/1/16 My name is Michael Mark Gottesman and my position is deputy director for intramural research at the National Institutes of Health. I was born on October 7, 1946 in Jersey City, New Jersey. And when I was around two years old, my family moved to Flushing, Queens, and I had most of my formative years growing up in Flushing. I cannot remember a time when I wasn’t interested in science. Probably the first interaction with issues related to public health was as one of many probably millions of children in the United States who got the Salk vaccine as a -- as a test. I remember lining up, they explained to us that this was a trial, and we all got shots, which was not that much fun for a six-year-old or a seven-year-old. And that was a huge sea change. I remember learning about the fact that before then people got polio, kids got polio. They wandered off to camp, they came back paralyzed. And after that period, we didn’t need to worry about polio. So I had the sense that there was a lot that biomedical research could do to alleviate human disease. The next big event scientifically in my life was the launch of Sputnik in 1957, and it was a wake-up call to the United States. We were so-called “falling behind” in the space race, and I was an eleven-year-old boy who was interested in space science. So I spent my childhood after that making rockets, probably not as safely as it should have been, but no unfortunate accidents befell me. -
Fn Ee Rw Ms I
FN EE RW MS I FERMILAB AU.S. DEPARTMENT OF ENERGY LABORATORY CDF Central Outer Tracker 10 Photo by Reidar Hahn Volume 23 INSIDE: Friday, May 26, 2000 Number 10 2 Sensenbrenner Visits Lab f 4 The DESYÐFermilab Connection 8 Next Phase of Wilson Hall Rehab 14 Letter to the Editor 14 Symposium on Fixed Target Program at the Tevatron House Science Committee Chairman James Sensenbrenner Jr. addresses the media after his tour of Fermilab. Opposite page: viewing a model of the lab site are (from left) Associate Director for Accelerators Steve Holmes, Sensenbrenner staffer Harlan Watson, Fermilab Director Michael Witherell and Chairman Sensenbrenner. by Mike Perricone Representative James Sensenbrenner Jr., (R-Wis.), chairman of the House Science Committee, left no one in the dark about his opinion of Fermilab. ÒFermilab is the jewel in the crown of scientific institutions in the United States,Ó Rep. Sensenbrenner said after a tour of the lab on March 15, including a visit to the manufacturing facility for superconducting magnets critical to the success of the Large Hadron Collider at CERN, the European particle physics laboratory in Geneva, Switzerland. Sensenbrenner: FERMILAB HAS Critical Role in Next Machine ÒSome of the other places IÕve been, IÕve seen big managerial problems and cost overruns,Ó he continued. ÒThatÕs not the case here, and thatÕs the way we want it to be. This place is well managed. Fermilab has a mission, and it accomplishes that mission.Ó Soon after becoming chairman of the science committee, Sensenbrenner played a critical role in the 1997 negotiations leading to the $531 million agreement for U.S. -
Chironian Spring/Summer 2010
Touro Scholar The Chironian NYMC Archives Publications Spring 2010 Chironian Spring/Summer 2010 New York Medical College Follow this and additional works at: https://touroscholar.touro.edu/nymc_arch_journals Part of the Higher Education Commons, and the Medicine and Health Sciences Commons Recommended Citation New York Medical College. (2010). Chironian Spring/Summer 2010. Retrieved from https://touroscholar.touro.edu/nymc_arch_journals/61 This Book is brought to you for free and open access by the NYMC Archives Publications at Touro Scholar. It has been accepted for inclusion in The Chironian by an authorized administrator of Touro Scholar. For more information, please contact [email protected]. New York Medical c o l l e g e c h i r o N i a N S p r i N g / S u mm e r 2 0 1 0 “In the coNtiNual reMeMbraNce of a gloriouS paSt, iNdiVidualS aNd Nations fiNd their NobleSt inspiratioN.” —Sir williaM Osler, aequaNiMitaS 1 8 6 0 – 2 0 1 0 c h i r o N i a N S p r i N g / S u mm e r 2 0 1 0 FEATURES ALUMNi NEWS — A TIMELINE OF NEW YORK MEDICAL 22 NOURISHING THE BONDS THAT KEEP COLLEGE HISTORY THE COLLEGE STRONG by Donna E. Moriarty, M.P.H. ’04 and by Andrea Kott, M.P.H. Kimberly Gaudin de Gonzalez 25 SIMULATED PATIENTS, 1 A LETTER TO THE COMMUNITY REAL PRACTICE by Karl P. Adler, M.D. and Ralph A. O’Connell, M.D. by Lynda McDaniel 2 PROTECTING CHILDREN, 26 MILESTONES INFORMING CAREGIVERS by Marjorie Roberts 26 KEEPING FIRST RESPONDERS “COMMUNICADO” by Lynda McDaniel 6 COUNTERING CHEMICAL THREATS: THE FINE ART OF HARD SCIENCE HE’LL TAKE MANHATTAN (AGAIN) by Marjorie Roberts 28 by Lynda McDaniel 9 LYME DISEASE: LEADERS, LANDMARKS, AND LOOKING AHEAD 30 2010 COMMENCEMENT & REUNIONS by Cynthia A. -
The Transhumanist Wager Zoltan Istvan
The Transhumanist Wager by Zoltan Istvan Copyright (c) 2013 Futurity Imagine Media LLC Published by Futurity Imagine Media LLC This is a work of fiction. Names, characters, places, and incidents are either the product of the author’s imagination or used fictitiously. Any resemblance to actual persons, living or dead, events, business establishments, or locales is entirely coincidental. All rights reserved. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher. Cover Design: Zoltan Istvan ISBN#: 978-0-9886161-1-0 Praise for Zoltan Istvan's writing and work: "Congratulations on an excellent story—really well written, concise, and elegant." Editor, National Geographic News Service "Istvan is among the correspondents I value most for his...courage." Senior Editor, The New York Times Syndicate "Thank you—you did a great interview for us." Producer, BBC Radio "Travel! Intrigue! Cannibals! Extreme journalism at far ends of Earth!" Headline featuring Zoltan Istvan, San Francisco Chronicle PART I Chapter 1 The Three Laws: 1) A transhumanist must safeguard one's own existence above all else. 2) A transhumanist must strive to achieve omnipotence as expediently as possible—so long as one's actions do not conflict with the First Law. 3) A transhumanist must safeguard value in the universe—so long as one's actions do not conflict with the First and Second Laws. —Jethro Knights' sailing log / passage to French Polynesia ************ Jethro Knights growled. His life was about to end. -
Zoltan Istvan
Zoltan Istvan Transhumanist Journalist and Entrepreneur Zoltan Istvan is often cited as the global leader of the radical science movement. A humanitarian activist and former journalist for National Geographic, Zoltan has been compared in major media to a young Al Gore and described as a modern-day Ayn Rand. Istvan is the founder of the Transhumanist Party, the author the Transhumanist Bill of Rights, and a frequently interviewed expert on AI. Before becoming an acclaimed futurist, he was a journalist for the National Geographic Channel (often an on-camera reporter) and The New York Times Syndicate. Istvan has traveled to over 100 countries, and has a degree in Philosophy and Religion from Columbia University. With his wildly popular US Presidential run as a science candidate, bestselling book The Transhumanist Wager, and powerful speeches at institutions like the World Bank, Zoltan Istvan has literally transformed transhumanism into a thriving worldwide phenomenon. He was the only presidential candidate to be interviewed by underground mega-group Anonymous. Beyond extensive media coverage, Zoltan is an eloquent, Ivy-league educated man yearning to use science, technology, reason to dramatically remake humanity. Zoltan has consulted for the US Navy as a futurist, interviewed to be Libertarian Gary Johnson's Vice President, appeared on the Joe Rogan Experience (and dozens of other shows), and gave many speeches, including at Microsoft, the Global Leaders Forum, and the Financial Times Camp Alphaville (opening Keynote). Zoltan Istvan frequently gives keynote speeches to large audiences on all topics of science, technology, and the future. As a world leader in his field, he's consulted for the US Navy, spoke at the World Bank, advised executives at multi-billion dollar corporations, moderated panels, hosted television segments, and publicly debated celebrities and policy experts. -
NCI Budget Fact Book for Fiscal Year 1996
NCI FACT BOOK National Cancer Institute 1996 U.S. DEPARTMENT NATIONAL INSTITUTES OF HEALTH AND OF HEALTH HUMAN SERVICES The information set forth in this publication is compiled and amended annually by the financial management staff of the National Cancer Institute and is intended primarily for use by members of the Institute, principal advisory groups to the Institute and others involved in the administration and management of the National Cancer Program. Questions regarding any of the information contained herein may be directed to the Financial Management Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland, 20892. TABLE OF CONTENTS Page Organization Director's Biography ........................................ 1 Former Directors of the NCI .................................. 2 National Cancer Advisory Board .............................. 3 Division Boards of Scientific Counselors ........................ 4 President's Cancer Panel .................................... 5 Executive Committee Members ............................... 5 Organization Charts: National Cancer Institute ................................... 6 Office of the Director ...................................... 7 Division of Basic Sciences .................................. 8 Division of Clinical Sciences ................................ 9 Division of Cancer Epidemiology and Genetics ................. 10 Division of Cancer Prevention and Control .................... 11 Division of Cancer Treatment, Diagnosis and Centers ............ 12 Division of -
A Review of Judah Folkman's Remarkable Achievements
RETROSPECTIVE A review of Judah Folkman’s remarkable achievements in biomedicine Yihai Cao*† and Robert Langer‡ *Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden; and ‡Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 n January 14th of this year, the biomedical research com- munity lost Judah Folkman, O the father of angiogenesis research. Folkman’s warm and humble personality, inspirational teaching, un- limited creativity, and vast clinical expe- rience have been described elsewhere (1). Here, we focus on Folkman’s in- effaceable scientific achievements in angiogenesis research, which revolution- ized biomedical research and clinical drug development. Folkman founded an entirely new field of basic and clinical research and discovered a previously unknown family of angiogenesis regulatory molecules. He showed experimentally how these molecules provide a fundamental mech- anism that controls the growth of virtually all tumors. He showed that expansion of tissue mass, whether Judah Folkman. (Image courtesy of Jon Chase/Harvard News Office.) neoplastic or nonneoplastic, critically depends on continuous endothelial rep- This 1971 report was the first to intro- the cornea, a methodology that was crit- lication and neovascularization. duce the concept of a novel form of tu- ical for proof of angiogenic bioactivity Those discoveries paved new avenues mor dormancy caused by blockage of of a given molecule in vivo (5). His re- for the development of a new class of angiogenesis. In that paper, Folkman search also identified the existence of a drugs, angiogenesis inhibitors, which have also introduced the concept of ‘‘anti- family of angiogenic peptides (6), and already provided novel therapies for hu- angiogenesis’’ as a potential novel anti- he showed that removing an angiogenic man cancer and age-related macular cancer therapy. -
2016 General Write-In Results
2016 General Election Official Write-In Results Precinct Precinct Name Office Candidate Votes Number ATTORNEY 01 BELLEFONTE N N/A 1 GENERAL AUDITOR 01 BELLEFONTE N N/A 1 GENERAL 01 BELLEFONTE N CONGRESS BLANK 1 01 BELLEFONTE N CONGRESS N/A 1 GENERAL 01 BELLEFONTE N ASSEMBLY - N/A 1 171ST 01 BELLEFONTE N PRESIDENT EVAN MCMULLIN 1 01 BELLEFONTE N PRESIDENT TILL KINGDOM COME (JESUS) 1 STATE 01 BELLEFONTE N N/A 1 TREASURER 01 BELLEFONTE N US SENATOR N/A 1 ATTORNEY 02 BELLEFONTE NE RON PAUL 1 GENERAL ATTORNEY 02 BELLEFONTE NE THOMAS SCHWARTZ 1 GENERAL GENERAL 02 BELLEFONTE NE ASSEMBLY - GERALD M. REITZ 2 171ST 02 BELLEFONTE NE PRESIDENT BERNIE SANDERS 1 02 BELLEFONTE NE PRESIDENT EVAN MCMULLIN 6 02 BELLEFONTE NE PRESIDENT TED CRUS 2 STATE 02 BELLEFONTE NE MICHAEL SNYDER 1 TREASURER ATTORNEY 03 BELLEFONTE S BLANK 1 GENERAL 03 BELLEFONTE S CONGRESS BRIAN SHOOK 1 03 BELLEFONTE S PRESIDENT BERNIE SANDERS 3 03 BELLEFONTE S PRESIDENT LYNN TAYLOR 1 03 BELLEFONTE S PRESIDENT MATTHEW J. TAYLOR 1 03 BELLEFONTE S PRESIDENT RAND PAUL 1 03 BELLEFONTE S PRESIDENT WILL MCMULLIN 1 ATTORNEY 04 BELLEFONTE SE JORDAN D. DEVIER 1 GENERAL 04 BELLEFONTE SE CONGRESS JORDAN D. DEVIER 1 04 BELLEFONTE SE PRESIDENT BERNIE SANDERS 1 04 BELLEFONTE SE PRESIDENT BURNEY SANDERS/MICHELLE OBAMA 1 04 BELLEFONTE SE PRESIDENT DR. BEN CARSON 1 04 BELLEFONTE SE PRESIDENT ELEMER FUDD 1 04 BELLEFONTE SE PRESIDENT EVAN MCMULLAN 1 04 BELLEFONTE SE PRESIDENT EVAN MCMULLIN 2 04 BELLEFONTE SE PRESIDENT JIMMY CARTER/GEORGE M.W. -
California Statewide Direct Primary Election Tuesday, June 5, 2018
California Statewide Direct Primary Election Tuesday June 5, 2018 Polls Are Open From 7:00 a.m. to 8:00 p.m. on Election Day! ★ ★ ★ ★ ★ OFFICIAL VOTER INFORMATION GUIDE ★ ★ ★ ★ ★ Certificate of Correctness I, Alex Padilla, Secretary of State of the State of California, do hereby certify that the measures included herein will be submitted to the electors of the State of California at the Primary Election to be held throughout the State on June 5, 2018, and that this guide has been correctly prepared in accordance with the law. Witness my hand and the Great Seal of the State in Sacramento, California, this 12th day of March, 2018. Alex Padilla, Secretary of State VOTER BILL OF RIGHTS YOU HAVE THE FOLLOWING RIGHTS: The right to vote if you are a registered voter. The right to get help casting your ballot 1 You are eligible to vote if you are: 6 from anyone you choose, except from your • a U.S. citizen living in California employer or union representative. • at least 18 years old • registered where you currently live The right to drop off your completed • not currently in state or federal prison 7 vote-by-mail ballot at any polling place in or on parole for the conviction of a California. felony • not currently found mentally The right to get election materials in a incompetent to vote by a court 8 language other than English if enough people in your voting precinct speak that language. The right to vote if you are a registered voter 2 even if your name is not on the list. -
Cuadernos De Divulgación Científica Sebbm "Acércate a Nuestros Científicos 2015-2017"
CUADERNOS DE DIVULGACIÓN CIENTÍFICA SEBBM "ACÉRCATE A NUESTROS CIENTÍFICOS 2015-2017" Imagen: Pinacoteca de la Ciencia. Contaminación (probablemente un hongo) en una rodaja de cerebro en cultivo. Autor: Javier Díaz (Dpto. de Bioquímica y Biología Molecular I, Universidad Complutense de Madrid). ÍNDICE DE CONTENIDOS 1. Enero 2015: Especial Premio Nobel de Química 2014: El nanoscopio (Cristina Flors)..................................................................................................................... pp. 4-5 2. Febrero 2015: Especial Premio Nobel Medicina 2014: De disparos y oscilaciones (Liset Menéndez de la Prida)................................................................................ pp. 6-7 3. Marzo 2015: Especial Premio Nacional de Investigación en Medicina “Gregorio Marañón” 2014: Jesús Prieto: Conocer el hígado para curarlo (Carmen Berasain)............................................................................................................... pp. 8-9 4. Marzo 2015 (2): Ceramidas: no sólo en las cremas de belleza (Alicia Alonso).............................................................................................................. pp. 10-11 5. Abril 2015: Citostasis y metástasis en cáncer (Francesc Ventura)............... pp. 12-13 6. Mayo 2015: Nuevos avances en la regulación redox del ciclo de la metionina (María de los Ángeles Pajares Tarancón).................................................................... pp. 14-15 7. Junio 2015: El reloj circadiano de Arabidopsis thaliana: ¡las plantas