Author Manuscript Published OnlineFirst on November 16, 2017; DOI: 10.1158/1078-0432.CCR-17-1366 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. The NOTCH4-HEY1 pathway induces epithelial mesenchymal transition in head and neck squamous cell carcinoma Authors: Takahito Fukusumi1, Theresa W Guo2, Akihiro Sakai1, Mizuo Ando1, Shuling Ren1, Sunny Haft1, Chao Liu1, Panomwat Amornphimoltham1, J. Silvio Gutkind1, Joseph A Califano1 1 Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, MC 0803 La Jolla, California 92093, U.S.A. 2 Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21231, U.S.A. Running Title: NOTCH4-HEY1 induces EMT in HNSCC Key Words: Head and neck squamous cell carcinoma, TCGA, NOTCH4, HEY1, EMT Financial Support This study was supported by National Institute of Dental and Craniofacial Research (NIDCR, number: R01DE023347). J.A.Califano received this grant. Correspondence: Joseph A. Califano, MD, Department of Otolaryngology - Head and Neck Surgery, University of California San Diego, 3855 Health Science Drive, MC 0803 La Jolla, California 92093, U.S.A. Phone: 619-543-7895; E-mail;
[email protected] Disclosure of Potential Conflict of Interest The authors declare no potential conflicts of interest. 1 Downloaded from clincancerres.aacrjournals.org on October 1, 2021. © 2017 American Association for Cancer Research. Author Manuscript Published OnlineFirst on November 16, 2017; DOI: 10.1158/1078-0432.CCR-17-1366 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. ABSTRACT Background: Recently, several comprehensive genomic analyses demonstrated NOTCH1 and NOTCH3 mutations in head and neck squamous cell carcinoma (HNSCC) in approximately 20% of cases.