Downloaded from http://mbe.oxfordjournals.org/ by guest on December 1, 2016 CORE 5 st3gal CONICET Digital CONICET by provided brought to you by by you to brought )distinguishing Pseudomonas aer- , 2,3-sialyltransferases Bernard Thisse,
5 Open Access se, and chicken tissues (re- 2013). Classically, vertebrate ). Therefore, variability of the so several lineage-specific gene iotemporal distribution of Gabius et al. 2002 ; Helicobacter pylori eny and large scale sequence similarity T3Gal VII, ST3Gal VIII, and ST3Gal IX. To Christine Thisse, e Lille Nord de France, Lille1, Villeneuve 4 2,3/6-sialyltransferases is likely to have played Harduin-Lepers 2010, phylogenetics, genomics, molecular modeling, 2,6-linked sialic acids to dock in the vertebrate host
st3gal-related genes, we performed comparative
Lehmann et al. 2006 ) also evolved this ability to read a specific sialylated 2,3- or ee Vicogne, sialyltransferases are classified into four families depending on tissues ( cognate major roles in the coevolution ofinteractions, these crucial although self and this nonself Twenty remains sialyltransferases a have been poorly describedized debated and mostly character- issue. in theviewed human, in mou siglecs involved in immune cell regulation.of Likewise, pathogenic a number agents such asoviruses) viruses and (influenza bacteria virus ( A, myx- uginosa sugar code (Gabius 2000 , distribution, and reproduction in any n, molecular evolutionary analyses using specificity deter- o the identification of amino acid residues with potential propose a detailed scenario of the evolutionary relationships contact [email protected] gene family history identified al Doroth 4 st3gal eculaire Animale, 123 avenue Albert Thomas, F-87060 Limoges Cedex, ructed the evolutionary history of the metazoan osition, evolution rates, coevolved amino acid. ,4 Varki 2006, half of the Society for Molecular Biology and Evolution. f the Creative Commons Attribution Non-Commercial License etique Mol brate subfamilies called ST3Gal III-r, S expressed sequence tag databases and search of conserved sialylmotifs led to the related gene sequences. Molecular phylog 2,3-Sialyltransferases (ST3Gal) Molecular en ases encompassing six subfamilies (ST3Gal I–ST3Gal VI) functionally characterized