Anti-TSC2 Monoclonal Antibody, Clone Z431 (DCABH-8588) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-TSC2 monoclonal antibody, clone Z431 (DCABH-8588) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit monoclonal to Tuberin

Antigen Description In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Specificity This antibody recognises Tuberous sclerosis complexe-2 (TCS2 also known as Tuberin. It is predicted to detect isoform 2-4 based on sequence homology.

Immunogen A synthetic peptide corresponding to residues in the C-term of human TSC2.

Isotype IgG

Source/Host Rabbit

Species Reactivity Mouse, Rat, Human

Clone Z431

Purity IgG fraction

Conjugate Unconjugated

Applications WB, IHC-P, Flow Cyt

Positive Control WB: Jurkat cell lysate IHC: prostate carcinoma

Format Liquid

Size 100 μl

Buffer PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%

Preservative 0.1% Sodium Azide

Storage store at -20°C. Avoid freeze / thaw cycles.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

GENE INFORMATION

Gene Name TSC2 tuberous sclerosis 2 [ Homo sapiens ]

Official Symbol Tsc2

Synonyms TSC2; tuberous sclerosis 2; TSC4; tuberin; LAM; tuberous sclerosis 2 protein; FLJ43106;

Entrez Gene ID 7249

Protein Refseq NP_000539

UniProt ID P49815

Chromosome Location 16p13.3

Pathway AKT phosphorylates targets in the cytosol, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Disease, organism-specific biosystem; Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem; Downstream signal transduction, organism-specific biosystem; Downstream signaling of activated FGFR, organism-specific biosystem.

Function 14-3-3 protein binding; GTPase activator activity; phosphatase binding; protein binding; protein heterodimerization activity; protein homodimerization activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]