Dose Rounding July 2016

Thames Valley Cancer Network Drug IV Concentration Rounding Rounding Rounding mg (mg/ml) (ml) (mg) entered on Aria if different Aflibercept 25 25 Banded - national Aldeslukin 1.1 0.1 0.11 0.1 Alemtuzumab 30 0.1 3 Amifostine 50 0 Amsacrine 5 1 5 Banded Arsenic trioxide 1 0 Banded - national Aspariginase 0 500 Azacitidine 25 0.2 5 Bendamustine 2.5 2.5 5 Banded - national Bevacizumab 25 1 25 Banded Bleomycin 5000iunits/ml 0.2 1000 Bleomycin IM 10000iunits/ml 1 10000 Bortezomib IV 1 0.1 0.1 Banded - national Bortezomib SC 2.5 Banded - national Brentuximab vedotin 5 5 5 Banded Busulphan 6 6 Banded - national Cabazitaxel 10 10 5 Banded - national Carboplatin 10 1 10 Banded - national Carfilzomib 2 1 2 Carmustine 3.3 3 9.9 10 Cetuximab 5 1 5 Banded Cisplatin 1 1 1 Banded - national Cladribine (Leustat) IV 1 0.2 0.2 Cladribine (Litak) subcut 2 0.1 0.2 Clofarabine 1 1 1 Banded - national Cyclophosphamide 20 1 20 Banded - national Cytarabine (200mg) 20 1 20 Banded - national Cytarabine (1g, 2g) 100 1 100 Banded - national Cytarabine IT 20 0.5 10 Cytarabine liposomal IT (Depocyte) 10 1 10 Dacarbazine 10 1 10 Banded - national Dactinomycin 1 0.1 0.1 Daratumumab 20 1 20 Daunorubicin 5 1 5 Banded - national Daunorubicin liposomal 2 1 2 Banded - national Docetaxel 20 1 20 Banded - national Doxorubicin 2 1 2 Banded - national Doxorubicin liposomal pegylated (Caelyx) 2 1 2 Banded - national Durvalumab 50 0.1 5 Epirubicin 2 1 2 Banded - national Eribulin 0.44 0.5 0.22 Banded Etoposide 20 0.5 10 Banded - national Etoposide liquid oral 20 1 20 Etoposide phosphate 10 1 10 Banded - national Fludarabine 25 0.2 5 Fluorouracil 25 1 25 Banded - national 11/08/2016 1 of 2 Thames Valley Cancer Network Drug IV Concentration Rounding Rounding Rounding mg (mg/ml) (ml) (mg) entered on Aria if different Fluorouracil 50 1 50 Banded - national Fluorouracil subconjunctival 25 0.2 5 Ganciclovir 50 1 50 Gemcitabine 100 1 200 Banded - national Gemtuzumab 1 0.5 0.5 Idarubicin 1 1 1 Banded - national Ifosfamide 80 1 80 Banded Mesna 100 1 100 Banded Ipilimumab 5 5 Banded Irinotecan 20 0.5 20 Banded - national Leucovorin 3 1 3 Melphalan 5 1 5 Banded - national Methotrexate 2.5 1 2.5 Banded - national Methotrexate 25 0.1 2.5 Banded - national Methotrexate 100 1 100 Banded - national Methotrexate IT 5 0.1 0.5 Mifamurtide 0.08 0.08 0.16 Mitomycin C 1 1 1 Banded - national Mitomycin C bladder 1 1 1 Mitomycin C ocular 0.4 0.5 0.2 Mitoxantrone 2 0.5 1 Banded - national Nelarabine 50 50 Banded Nivolumab 10 Banded Obinutuzumab 25 1 25 Ofatumumab 20 1 20 Oxaliplatin 5 1 5 Banded - national Paclitaxel 6 1 6 Banded - national Paclitaxel albumin bound 5 20 Banded - national Panitumumab 20 0.5 10 Banded Pembrolizumab Banded Pemetrexed 25 1 25 Banded - national Raltitrexed 0.5 1 0.5 Rituximab 10 1 100 Banded - national Romidepsin 5 Banded - national Siltuximab 20 0.5 10 Streptozocin 100 0.1 100 Banded - national Thiotepa 10 Banded - national Topotecan 1 0.1 0.1 Banded - national Trabectedin 0.05 1 0.05 Trastuzumab 21 1 21 Banded Trastuzumab emtandine 20 Banded Treosulfan 50 1 50 Banded Vinblastine 1 0.5 0.5 Banded - national Vincristine 1 0.1 0.1 Banded - national Vindesine 1 0.5 0.5 Banded - national Vinflunine 25 1 25 Banded - national Vinorelbine 10 0.5 5 Banded - national 11/08/2016 2 of 2.

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A Phase II Study of the Novel Proteasome Inhibitor Bortezomib In
Memorial Sloan-Kettering Cance r Center IRB Protocol IRB#: 05-103 A(14) A Phase II Study of the Novel Proteas ome Inhibitor Bortezomib in Combination with Rituximab, Cyclophosphamide and Prednisone in Patients with Relapsed/Refractory I Indolent B-cell Lymphoproliferative Disorders and Mantle Cell Lymphoma (MCL) MSKCC THERAPEUTIC/DIAGNOSTIC PROTOCOL Principal Investigator: John Gerecitano, M.D., Ph.D. Co-Principal Carol Portlock, M.D. Investigator(s): IFormerly: A Phase I/II Study of the Nove l Proteasome Inhibitor Bortezomib in Combinati on with Rituximab, Cyclophosphamide and Prednisone in Patients with Relapsed/Refractory Indolent B-cell Lymphoproliferative Disorders and Mantle Cell Lymphoma (MCL) Amended: 07/25/12 Memorial Sloan-Kettering Cance r Center IRB Protocol IRB#: 05-103 A(14) Investigator(s): Paul Hamlin, M.D. Commack, NY Steven B. Horwitz, M.D. Philip Schulman, M.D. Alison Moskowitz, M.D. Stuart Lichtman, M.D Craig H. Moskowitz, M.D. Stefan Berger, M.D. Ariela Noy, M.D. Julie Fasano, M.D. M. Lia Palomba, M.D., Ph.D. John Fiore, M.D. Jonathan Schatz, M.D. Steven Sugarman, M.D David Straus, M.D. Frank Y. Tsai, M.D. Andrew D. Zelenetz, M.D., Ph.D. Matthew Matasar, M.D Rockville Center, NY Mark L. Heaney, M.D., Ph.D. Pamela Drullinksy, M.D Nicole Lamanna, M.D. Arlyn Apollo, M.D. Zoe Goldberg, M.D. Radiology Kenneth Ng, M.D. Otilia Dumitrescu, M.D. Tiffany Troso-Sandoval, M.D. Andrei Holodny, M.D. Sleepy Hollow, NY Nuclear Medicine Philip Caron, M.D. Heiko Schoder, M.D. Michelle Boyar, M.D.
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Clinical Efficacy of Irinotecan Plus Raltitrexed
Clinical ecacy of irinotecan plus raltitrexed chemotherapy in refractory esophageal squamous cell cancer: a retrospective study Min Liu Clinical Medical College, Yangzhou University Qingqing Jia Clinical Medical College,Yangzhou University Xiaolin Wang Clinical Medical College, Yangzhou University Changjiang Sun Clinical Medical College, Yangzhou University Jianqi Yang Clinical Medical College, Yangzhou University Yanliang Chen Clinical Medical College, Yangzhou University Ying Li Clinical Medical College, Yangzhou University Lingfeng Min Clinical Medical College, Yangzhou University Xizhi Zhang Clinical Medical College, Yangzhou University Caiyun Zhu Clinical Medical College, Yangzhou University Johannes Artiaga Gubat Linkoping University Yong Chen ( [email protected] ) https://orcid.org/0000-0002-3876-0158 Research article Keywords: Esophageal cancer, Irinotecan, Raltitrexed, Chemotherapy Posted Date: September 5th, 2019 DOI: https://doi.org/10.21203/rs.2.13923/v1 Page 1/16 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 2/16 Abstract Background: The optimal chemotherapy regimen for refractory esophageal squamous cell cancer patients is uncertain. Our retrospective study assessed the ecacy and safety of irinotecan plus raltitrexed in esophageal squamous cell cancer patients who were previously treated with multiple systemic therapies. Methods: Between January 2016 and December 2018, records of 38 esophageal squamous cell cancer patients who underwent irinotecan plus raltitrexed chemotherapy after at least one line of chemotherapy were reviewed. Ecacy assessment was performed every two cycles according to the RECIST version 1.1. Results: A total of 95 cycles of chemotherapy were administered, and the median course was 3 (range 2– 6). There was no treatment-related death. Nine patients had partial response, 21 had stable disease and 8 had progressive disease.
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Diarrhea Increased with Targeted Cancer Agents
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(12) Patent Application Publication (10) Pub. No.: US 2013/0211215 A1 Heglund Et Al
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