The Netherlands Food and Consumer Product Safety Authority Status 21 September 2011

TEST FACILITY DATE OF INSPECTION STATUS NATURE OF INSPECTION AREA OF EXPERTISE REMARKS

Agrevo Nederland BV 06.1997 PEN FULL 6: field phase new name since 01.2000 Oosterweg 127 09.1997 IC RE-I 6: field phase Aventis CropScience NL-9750 AC Haren RFP Benelux BV, Oosterhout AgriChem BV 12.2009 IC FULL 1 former name until 11.2007 Koopvaardijweg 9, PO Box 295, Brabant Chemie BV NL-4900 AG Oosterhout Agro Research International BV 11.2002 IC FULL 6: field phase Langeweg 5, NL-4756 AH Kruisland 02.2006 IC FULL 02.2009 IC FULL 6: field phase Akzo Nobel Central Research (ACR), 12.1988 PEN FULL 4, 5 new name since 02.2002 Ecotoxicology Laboratory 10.1989 IC FULL Akzo Nobel Chemicals Velperweg 76, PO Box 9300 06.1991 IC FULL BV, Environm. Chem. & NL-6800 SB Arnhem 06.1993 IC FULL Regulatory Affairs Dept. 07.1995 IC FULL 4, 5 02.1998 IC FULL 1, 4, 5 RFP Akzo Nobel Chemicals BV, Environmental 02.2002 IC FULL 1, 4, 5 former name until 02.2002 Chemistry & Regulatory Affairs Dept. 01.2005 PEN FULL Akzo Nobel Centr Res Velperweg 76, PO Box 9300 09.2005 IC RE-I 1, 4, 5 Ecotox Lab NL-6800 SB Arnhem RFP new name since 04.2006 Akzo Nobel Technology & Engineering BV Akzo Nobel Technology & Engineering BV 01.2008 IC FULL 1,4,5 former name until 04.2006 Environmental Chemistry Department 02.2010 IC FULL 1,4,5 Akzo Nobel Chemicals BV Velperweg 76.NL-6824 BM Arnhem

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Alterra BV, Center for Water & Climate, 12.2002 PEN FULL 4, 5 Droevendaalsesteeg 3, PO Box 47, 12.2003 IC RE-I 4, 5 NL-6700 AA Wageningen 09.2005 IC FULL 4, 5, 7 02.2008 PEN FULL 12.2008 IC RE-I 02.2011 PEN FULL 4, 5, 7 Ambrosiushoeve Research Centre 02.2000 PEN FULL 4: bees, bumblebees new name since 01.2001 Ambrosiusweg 1 12.2000 NIC RE-I Applied Plant Research, NL-5081 NV Hilvarenbeek RFP Research Unit Apiculture Analytico Medinet BV 08.2000 IC FULL 8 former name until 03.99 Bergschot 71, PO Box 5510 02.2004 IC FULL 8 BCO Centre for Research NL-4800 CD Breda 03.2006 PEN FULL new name since 11.06 RFP Eurofins Medinet BV Analytisch Biochemisch Lab. BV (ABL) 02.1992 PEN FULL 8 W.A. Scholtenweg 7, PO Box 232 04.1992 IC RE-I NL-9400 AE Assen 11.1995 IC FULL 09.1998 IC FULL 07.2001 PEN FULL 12.2001 IC RE-I 09.2004 IC FULL 11.2006 IC FULL 09.2009 IC FULL 8 Applied Plant Research BV, Bee Research Unit, 08.2002 IC FULL 4: bees, bumblebees former name until 01.2001 Droevendaalsesteeg 1 11.2005 IC FULL 4: bees, bumblebees Ambrosiushoeve Res. Cntr NL-6700 AB Wageningen RFP former address until 10.2004 5081 NV Hilvarenbeek RFP: left programme 01.2011 Aquasense Lab BV 06.1998 PEN FULL 4,5 left program 12.2000 Kruislaan 411A 11.1998 IC RE-I 4,5 NL-1090 HC Amsterdam RFP

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Astellas Pharma Europe BV, Exploratory 08.2006 IC FULL 8 former name until 08.2005 Development Department, Bioanalysis Laboratory, 09.2008 IC FULL 8 Yamanouchi Europe BV Elisabethhof 1, PO Box 108 12.2010 IC FULL 8 NL-2350 AC Leiderdorp Aventis Cropscience Benelux BV 12.2001 IC FULL 6: field phase former name until 01.2000 Logistiekweg 18 RFP AgrEvo Nederland, Haren NL-4900 AC Oosterhout left program 06.2003 Bactimm BV 09.2002 PEN FULL Middenkampweg 16 08.2003 IC RE-I NL-6545 CH Nijmegen 02.2006 IC FULL 9: validation of microbial 06.2009 IC FULL en endotoxine tests BCO Centre for Research, 06.1988 PEN FULL 8 new name since 03.1999 Bergschot 71 11.1988 IC RE-I 8 Analytico Medinet BV NL-4800 CD Breda 02.1991 PEN FULL 1, 8 05.1991 IC RE-I 06.1993 PEN FULL 10.1993 IC RE-I 1, 8 10.1996 IC FULL RFP Biomedical Primate Research Centre (BPRC) 04.1998 PEN FULL 2 left program 07.2002 Lange Kleiweg 139 02.1999 IC RE-I 2 NL-2280 GH Rijswijk RFP Bioscan BV, 04.1996 PEN FULL 9: biocompatibility left program 11.2004 Prof. Bronkhorstlaan 10-H 09.1996 IC RE-I medical devices NL-3723 MB Bilthoven 03.2000 IC FULL 04.2003 NIC FULL 09.2003 PEN FULL 04.2004 IC RE-I 9: biocompatibility RFP medical devices

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Brabant Chemie BV 11.1997 PEN FULL 1 New name since 11.2007: Koopvaardijweg 9, PO Box 295, 06.1998 IC RE-I AgriChem BV NL-4900 AG Oosterhout 10.2000 IC FULL 06.2003 IC FULL 05.2005 IC FULL 10.2007 IC FULL 1 RFP Central Laboratory Animal Institute 12.2000 NIC FULL 2 left program 07.2006 Bolognalaan 50, PO Box 80190 03.2002 IC FULL NL-3508 TD Utrecht 04.2005 PEN FULL 2 RFP Central Veterinary Institute, Animal Sciences 05.2008 IC FULL 6, 9: Safety studies former name until 01.2008 Group, Edelhertweg 15, NL-8219 PH Lelystad ID-Lelystad BV Cerexagri BV 06.2003 IC FULL 1 former name until 02.2001 Tankhoofd 10, PO Box 6030, 10.2005 IC FULL Elf Atochem Agri BV NL-3196 XH Vondelingenplaat/Rotterdam 09.2007 IC FULL 11.2009 IC FULL 1 Crovin BV 02.2002 NIC FULL 6, 9: toxicokinetics former name until 01.2000 Mechelaarstraat 3 RFP R&W Bio Research NL-4903 RE Oosterhout left program 11.2002 Crucell Holland BV 06.2008 IC FULL 8 Archimedesweg 4-6, NL-2333CN Leiden 09.2010 IC FULL 8 Cyanamid Agro Nederland 12.1997 IC FULL 6: field phase left program 03.2001 Druivenstraat 1, PO Box 3607 NL-4800 DP Breda RFP Dannalabs BV 05.2011 PEN FULL 1: X-ray characterisation Wethouder Beversstraat 185 07.2011 IC RE-I 7543 BK Enschede De Bredelaar BV 02.1995 IC FULL 6: field phase Research Company for Plant Protection 11.1997 IC FULL Breedlersestraat 7 12.2001 IC FULL NL-6662 NP Elst 10.2004 IC FULL 11.2006 IC FULL 12.2009 IC FULL 6: field phase

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Dopharma Research BV 03.1996 PEN FULL 2, 6, 8, 9: Zalmweg 24, PO Box 205 10.1996 IC RE-I pharmacokinetics NL-4941 VX Raamsdonkveer 12.1999 IC FULL 03.2002 IC FULL 02.2005 IC FULL 09.2007 IC FULL 2, 6, 8, 9: 01.2010 IC FULL pharmacokinetics Dow Benelux BV Product Safety Labs 12.1993 IC FULL 1,8 left program 07.1997 H.H. Dowweg 5, PO Box 48 03.1997 IC FULL 8 NL-4530 AA Terneuzen RFP DSM Food Specialties R&D, Analysis Dept. 11.2003 IC FULL 8 former name until 11.2003 A. Fleminglaan 1 RFP DSM Research, Dept NL-2600 MA Delft Analysis for Life Sciences left program 07.2005 DSM Research, Dept Analysis for Life Sciences 04.2000 PEN FULL 8 new name since 11.2003 A. Fleminglaan 1 11.2000 IC RE-I 8 DSM Food Specialties NL-2600 MA Delft RFP R&D, Analysis Dept Duphar, Toxicology Department 10.1988 IC FULL 2, 3 new name since 04.1994 C.J. van Houtenlaan 36, PO Box 900 06.1991 IC FULL 2, 3 Solvay Duphar BV NL-1380 DA Weesp RFP Elf Atochem Agri BV 09.1997 IC FULL 1 new name since 02.2001 Tankhoofd 10, PO Box 6030, 05.2000 IC FULL 1 Cerexagri BV NL-3196 XH Vondelingenplaat/Rt RFP Erasmus Medical Center, Dept of Medical 04.2006 IC FULL 8 Oncology, Groene Hilledijk 301 10.2008 IC FULL 8 NL-3075 EA Rotterdam 11.2010 IC FULL 8 Eurofins Medinet BV 11.2006 IC RE-I 8 former name until 11.2006 Bergschot 71, PO Box 5510 02.2008 IC FULL Analytico Medinet BV NL-4800 CD Breda 05.2010 IC FULL 8

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Farma Research BV 12.1992 PEN FULL 6, 8, 9: pharmacokinetics new name since 09.2005 Adelbertusplein 1, PO Box 9101 (164) 03.1993 IC RE-I Farma Research Animal NL-5370 AA Nijmegen 12.1994 IC FULL Health 10.1997 PEN FULL 06.1998 IC RE-I 09.2001 IC FULL 09.2004 PEN FULL 05.2005 IC RE-I 6, 8, 9: pharmacokinetics RFP Farma Research Animal Health 06.2007 PEN FULL 6, 9: tolerance, former name until 09.2005 Toernooiveld 300-H 02.2008 IC RE-I bioequivalence, Farma Research BV NL-6525 EC Nijmegen 06.2010 IC FULL pharmacokinetics Fort Dodge Animal Health Holland 08.1997 IC FULL 2, 9: pharmacokinetics left program 06.2003 CJ van Houtenlaan 36, PO Box 36 11.2001 PEN FULL safety studies on vaccines NL-1380 DA Weesp 06.2002 IC RE-I RFP Gist Brocades, Toxicology Lab 05.1988 PEN FULL 2 left program 06.1991 Wateringseweg 1 02.1990 PEN FULL 2 NL-2600 MA Delft RFP Global Pathology Support 09.2005 IC FULL 2: Pathology Benoordenhoutseweg 23 04.2008 IC FULL NL-2596 BA Den Haag 08.2010 IC FULL 2: Pathology Haemoprobe BV 09.2003 NIC FULL 9: biocompatibility left program 01.2004 L.J. Zielstraweg 1, NL-9713 GX Groningen RFP medical devices Hazleton Biotechnologies 03.1987 IC FULL 3 left program 01.1989 Landjuweel 11, PO Box 454 RFP NL-3900 AL Veenendaal ID-DLO, Experimental Animal Services Dept 12.1998 PEN FULL 6, 9: pharmacokinetics new name since 01.2000 Edelhertweg 15 RFP ID-Lelystad BV NL-8200 AB Lelystad

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ID-Lelystad BV 04.2000 IC FULL 6,9: pharmacokinetics former name until 01.2000 Edelhertweg 15 10.2002 NIC FULL ID-DLO NL-8200 AB Lelystad 12.2004 NIC FULL 09.2006 IC FULL 6,9: safety studies new name since 01.2008 RFP Central Veterinary Institute Intervet International BV 02.1995 IC FULL 2,6,8,9: safety studies W. de Körverweg 35 06.1997 IC FULL NL-5831 Boxmeer 06.2000 IC FULL 10.2003 IC FULL new name since 11.2007 12.2005 IC FULL 2,6,8,9: safety studies Intervet Schering Plough RFP Animal Health Intervet Schering Plough Animal Health 04.2008 IC FULL 2,6,8,9: safety studies former name until 11.2007 W. de Körverweg 35, NL-5831 Boxmeer 09.2010 IC FULL 2,6,8,9: safety studies Intervet International BV Isotis NV, Prof. Bronkhorstlaan 10-D, PO Box 98 03.2001 IC FULL 9: preclinical studies left program 07.2003 NL-3723 MB Bilthoven RFP IVR, Institute Veterinarian Research, 09.1996 NIC FULL 2, 6 left program 01.1997 Vollenhofseweg 3, PO Box 81, NL-8090 AB RFP Wezel KCL BioAnalysis BV 02.2004 IC FULL 8 former name until 05.2001 Borniastraat 34 RFP KCL, Stichting Klinisch NL-8901 BR Leeuwarden Chemisch Laboratorium left program 07.2006 KCL, Stichting Klinisch Chemisch Lab 02.1997 IC FULL 8 new name since 05.2001 Borniastraat 34 02.2001 IC FULL 8 KCL BioAnalysis BV NL-8901 BR Leeuwarden RFP Kinesis Pharma BV 11.2003 IC FULL 9: pharmaco- & toxico- Lage Mosten 29, 4822 NK Breda 02.2006 IC FULL kinetic data analyses 05.2009 IC FULL 08.2011 IC FULL Medinet VOF, Central Office / RTC Breda BV 09.1994 IC FULL 8 new name since 09.1998 Bergschot 69 12.1995 IC RE-I 8 Medinet VOF / CRL (clin. NL-4800 CC Breda RFP ref. lab.)

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Medinet VOF, CRL (Clinical Reference 09.1998 NIC FULL 8 former name until 09.1998 Laboratory), Bergschot 69 RFP Medinet VOF / RTC NL-4800 CC Breda left program 01.1999 Merck Millipore, 09.2010 IC FULL 9: tests for microbial former name until 09.2010 MicroSafe BioSafety Solutions Laboraty contamination and Microsafe Services from Darwinweg 24, NL-2333 CR Leiden identification Millipore Microsafe BV 05.1994 IC FULL 9: tests for microbial new name since 07.2005 N. Bohrweg 11-13 05.1997 IC FULL contamination and MicroSafe Services from NL-2333 CA Leiden 11.2000 PEN FULL identification Millipore 06.2001 IC RE-I 04.2004 IC FULL RFP MicroSafe Services from Millipore 12.2007 PEN FULL 9: tests for microbial former name until 07.2005 Darwinweg 24 09.2008 IC RE-I contamination and Microsafe BV; NL-2333 CR Leiden RFP identification new name since 09.2010: Merck Millipore Microsafe BioSafety Solutions Lab Mitox Consultants 07.1996 PEN FULL 4: arthropods Kruislaan 320, PO Box 92260, 01.1997 IC RE-I NL-1098 SN Amsterdam 03.2000 IC FULL 03.2003 IC FULL 02.2006 IC FULL 04.2009 IC FULL 4: arthropods MSD, NV Organon, Bioanalytics Department 06.2010 IC FULL 8 former name until 06.2010 Molenstraat 110, PO Box 20 Organon NV, Bioanalytics NL-5340 BH Oss MSD, NV Organon, Toxicology & Drug 06.2010 IC FULL 2,3,8,9: toxicokinetics former name 06.2010: Disposition Department Organon NV, Toxicology Nistelrooisebaan 3, NL-5374 RE Schaijk & Drug Disposition Dept. Nobilon International BV, Wim de Körverstraat 35 04.2009 IC FULL 2 left program 11.2010 5831 AN Boxmeer RFP Notox C.V., Hambakenwetering 31, 04.1987 IC FULL 2, 3, 4 new name since 02.1988 NL-5231 BD ‘s-Hertogenbosch RFP RCC Notox

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NOTOX BV 11.1993 IC FULL 1,2,3,4,5,8 former name until 11.1993 Hambakenwetering 7, PO Box 3476, 10.1996 IC FULL RCC Notox Research & NL-5203 DL ‘s Hertogenbosch 10.1999 IC FULL 1,2,3,4,5,8 Consulting Company BV 05.2002 IC FULL 1,2,3,4,5,6,8,9: kinetics; 02.2005 IC FULL metabolism 04.2007 IC FULL 02.2009 IC FULL 1,2,3,4,5,6,8,9: kinetics; 03.2011 IC FULL metabolism; safety pharmacology Organon International BV 11.1987 IC FULL 2, 3, 8 new name since 07.1999 Preclinical Development Laboratories 03.1990 PEN FULL Organon NV, Depts Drug Molenstraat 110, PO Box 20 09.1990 IC RE-I Metabolism & Kinetics, NL-5340 BH Oss 11.1992 IC FULL Toxicology & Drug 02.1996 IC FULL 2, 3, 8 Disposition RFP Organon NV, Bioanalytics Department 10.2007 IC FULL 8 former name until 04.2007 Molenstraat 110, PO Box 20 RFP Organon NV, Clinical NL-5340 BH Oss Pharmacol. & Kinetics; new name since 06.2010: MSD Organon, Bioanalytics Department Organon NV 06.2005 IC FULL 8 former name until 06.2005 Clinical Pharmacology & Kinetics Department RFP Organon, Drug Metabolism Molenstraat 110, PO Box 20 & Kinetics NL-5340 BH Oss new name since 04.2007 Organon NV, Department of Bioanalytics Organon NV 07.1999 IC FULL 8 former name until 07.1999 Drug Metabolism & Kinetics Department 07.2002 IC FULL 8 Organon Intern., Preclin. Molenstraat 110, PO Box 20 RFP Dev. Labs NL-5340 BH Oss new name since 06.2005 Clinical Pharmacology & Kinetics

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Organon NV, 07.1999 IC FULL 2,3 former name until 07.1999 Toxicology & Drug Disposition Department 06.2002 IC FULL 2,3 Organon Intern., Preclin. Nistelrooisebaan 3 06.2005 IC FULL 2,3,9: toxicokinetics Dev. Labs NL-5374 RE Schaijk 10.2007 IC FULL 2,3,8,9: toxicokinetics new name since 06.2010: RFP MSD Organon,, Toxicology & Drug Disposition Dept. Pharma BioResearch Group BV 09.2000 PEN FULL 8 former name until 07.1999 Stationsweg 163, PO Box 200 04.2001 IC RE-I 8 Pharma BioResearch Int. NL-9470 AE Zuidlaren 05.2004 PEN FULL new name since 07.2006 04.2005 IC RE-I PRA Int. , Early Dev. Serv. RFP Pharma BioResearch International BV 10.1993 IC FULL 8 new name since 07.1999 Stationsweg 163, PO Box 200 09.1996 IC FULL 8 Pharma BioResearch NL-9470 AE Zuidlaren RFP Group BV PRA International, Early Development Services 12.2007 IC FULL 8 former name until 07.2006 Westerbrink 3 09.2010 IC FULL 8 Pharma BioResearch NL-9405 BJ Assen Group Proeftuin Zwaagdijk 03.2004 PEN FULL 6: field phase Tolweg 13 11.2004 IC RE-I NL-1681 ND Zwaagdijk-Oost 04.2006 IC FULL 10.2009 IC FULL 6: field phase Proxy Laboratories BV 04.2005 NIC FULL 8 Archimedesweg 25 12.2005 IC FULL 8 NL-2333 CM Leiden 06.2008 IC FULL 8 01.2011 PEN FULL 8 QPS Netherlands BV 02.2011 IC FULL 8 previous name until Petrus Campersingel 123 09.2010 Xendo Drug 9713 AG Groningen Development BV RCC Notox Research & Consulting Company BV, 03.1989 PEN FULL 1,2,3,4 former name until 02.1988 Hambakenwetering 7 11.1989 IC RE-I Notox C.V. NL-5231 DD ‘s Hertogenbosch 11.1991 IC FULL 1,2,3,4 new name since 11.1993 RFP Notox BV

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Redened BV 04.1995 PEN FULL 6: field phase left program 01.2009 Panhuysstraat 6, PO Box 24009 11.1995 IC RE-I NL-6363 ZG Wijnandsrade 09.1999 IC FULL 01.2003 PEN FULL 01.2004 IC RE-I 05.2007 IC FULL 6: field phase RFP Reinier de Graaf Diagnostisch Center SSDZ 03.1999 NIC FULL 9: virus removal left program 04.2003 R de Graafweg 3-11, NL-2600 GA Delft RFP Rephartox BV, Zuidersluisweg 2 11.2006 PEN FULL 8 left program 10.2007 NL-8243 RC Lelystad RFP Rhône-Poulenc Agro BV 06.1995 IC FULL 6: field phase new name since 01.2000 Zeedijk 47, PO Box 209 11.1997 IC FULL 6: field phase Aventis CropScience NL-4870 AE Etten-Leur RFP Benelux BV Rikilt Institute of Food Safety 01.1998 IC RE-I 6,8 left program 11.2006 Bornsesteeg 45, PO Box 230, 03.2001 PEN FULL 6,8,9: kinetics NL-6700 AE Wageningen 02.2002 IC RE-I 6,8,9: kinetics 04.2005 PEN FULL 6,8 12.2005 IC RE-I 6,8 RFP RIVM-ARO, Residue analysis Laboratory 02.1994 PEN FULL 8 left program 08.2002 Antonie van Leeuwenhoeklaan 9, Postbus 1 12.1994 IC RE-I NL-3720 Bilthoven 01.1998 IC FULL 07.2001 PEN FULL 8 RFP RIVM-BFT, Unit Biotransformation, Farmaco- & 06.1992 NIC FULL 2,3 left program 01.1999 Toxicokinetics, A.van Leeuwenhoeklaan 9, 12.1993 IC FULL 2,3 PO.Box 1, NL-3720 BA Bilthoven RFP RIVM-BKG, Quality Assurance Bureau 06.1992 NIC 9: quality assurance left program 01.1996 NL-3720 BA Bilthoven 01.1996 RFP RIVM-CDL, Central Animal Laboratory 12.1993 IC FACI 2: animal husbandry left program 03.2002 Antonie van Leeuwenhoeklaan 9, Postbus 1 08.1996 IC FACI NL-3720 BA Bilthoven 02.2000 IC FACI 2: animal husbandry RFP

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RIVM-ECO, Ecotoxicology Laboratory 09.1993 PEN FULL 4,5 left program 11.1995 NL-3720 BA Bilthoven 02.1995 PEN FULL 4,5 RFP RIVM-LBG, Laboratory for Soil & Ground-water 01.1998 PEN FULL 6: field phase left program 09.1999 Research, NL-3720 BA Bilthoven RFP RIVM-LCM, Carcino-and Mutagenesis Lab. 06.1992 NIC FULL 2,3 left program 02.1996 Antonie van Leeuwenhoeklaan 9, Postbus 1 01.1995 IC FULL 2,3 NL-3720 BA Bilthoven RFP RIVM-LPI, Laboratory for Pathology & 02.1996 IC FULL 2 former name until 02.1996 Immunobiology , Antonie van Leeuwenhoeklaan 09.1999 IC FULL 2 RIVM-PAT 9, Postbus 1, NL-3720 BA Bilthoven RFP left program 03.2002 RIVM-PAT, Laboratory for Pathology 01.1993 IC FULL 2 new name since 02.1996 NL-3720 BA Bilthoven RFP RIVM-LPI RIVM-TEP, Unit Teratology, Endocrinology & 06.1992 NIC FULL 2,3 left program 11.1995 Perinatal Screening 01.1995 PEN FULL 2,3 NL-3720 BA Bilthoven RFP RIVM-TOX, Toxicology Laboratory 06.1992 NIC FULL 2 left program 02.1996 NL-3720 BA Bilthoven 01.1993 IC FULL 2 RFP R&W Bio Research 09.1995 PEN FULL 8, 9: pharmacokinetics new name since 01.2000 Mechelaarstraat 3 01.1996 IC RE-I Crovin BV NL-4903 RE Oosterhout 02.1999 IC FULL 8, 9: pharmacokinetics RFP Sanquin, Research Division, Virus Safety Services 11.2004 PEN FULL 9: validation of virus Laboratory 12.2005 IC RE-I removal/inactivation Plesmanlaan 125, PO Box 9190, 11.2007 PEN FULL NL-1006 AD Amsterdam 12.2008 IC RE-I 03.2011 IC FULL 9: validation of virus and prion removal/ inactivation

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Slotervaart Hospital, Pharmacy & Pharmacology 05.1999 IC FULL 8 Department, Bioanalytical Laboratory 02.2002 IC FULL Louwesweg 6, PO Box 90440, 09.2004 IC FULL NL-1066 EC Amsterdam 01.2007 IC FULL 09.2009 IC FULL 8 Solvay Duphar BV, Departments Drug Safety, 04.1994 IC FULL 2, 3, 4, 5, 8, 9: former name until 04.1994 Bio-Analysis, and Environmental Research 02.1997 IC FULL pharmacokinetics Duphar, Toxicology Dept NL-1380 DA Weesp RFP new name since 06.2000 Solvay Pharmaceuticals Solvay Pharmaceuticals BV 06.2000 IC FULL 1,2,4,8 former name until 06.2000 C.J. van Houtenlaan 36, PO Box 900 03.2004 IC FULL Solvay Duphar BV NL-1380 DA Weesp 06.2006 IC FULL RFP: left programme 06.2009 IC FULL 1,2,4,8 06.2011 RFP Syngenta Crop Protection BV, 01.2002 IC FULL 6: field phase former name until 01.2001 Stepvelden 8 12.2004 IC FULL 6: field phase Zeneca NL-4700 BA Roosendaal RFP left program 09.2006 TNO-CIVO 06.1987 PEN FULL 2,3 new name since 02.1993 Utrechtseweg 48, PO Box 360 12.1987 PEN RE-I TNO-ITV NL-3700 AJ Zeist 09.1988 PEN FULL 02.1989 IC RE-I 03.1991 IC FULL 2,3 RFP TNO Defence, Security & Safety 04.2007 IC FULL 1 former name until 01.2005 Lange Kleiweg 137, PO Box 45 10.2009 PEN FULL 1 TNO-PML, Prins Maurits NL-2280 AA Rijswijk 05.2010 IC RE-I 1 Laboratory TNO Imares BV 02.2007 PEN FULL 5,7 former name until 01.2007 Ambachtsweg 8a, PO Box 57 06.2008 NIC RE-I TNO Inst. Environmental NL-1780 AB Den Helder RFP Scns, Energy Res &Process Innov, Ecol. Risk Studies RFP: 01.2011 TNO-IMW, TNO Institute of Environmental 04.1991 PEN FULL 8 left program 04.1996 Sciences, Analytical Chemistry Dept. 11.1992 IC RE-I Schoemakerstraat 97 10.1994 IC FULL 8 NL-2628 VK Delft RFP 13 TEST FACILITY DATE OF INSPECTION STATUS NATURE OF INSPECTION AREA OF EXPERTISE REMARKS

TNO-IMW, TNO Institute of Environmental 04.1991 IC FULL 4,5 former name until 04.1991 Sciences, Biology Department 12.1994 IC FULL 4,5 TNO-MT, Biology Dept Schoemakerstraat 97 RFP new name since 01.1996 NL-2628 VK Delft TNO Nutrition & Food Res., Toxicology Division TNO Institute of Environmental Sciences, 05.2001 IC FULL 7 new name since 01.2007 Energy Research and Process Innovation, 03.2004 PEN FULL 5,7 TNO Imares BV Dept. for Ecological Risk Studies, Ambachtsweg 12.2004 IC RE-I 5,7 8a, PO Box 57, NL-1780 AB Den Helder RFP TNO-ITV 02.1993 IC FULL 2, 3 former name until 02.1993: Utrechtseweg 48, PO Box 360 RFP TNO-CIVO NL-3700 AJ Zeist new name since 06.1995 TNO Nutrition & Food Res., Toxicology Division TNO-MT, TNO Institute of Environmental 12.1988 IC FULL 4 new name since 04.1991 Sciences, Biology Department, Schoemakerstraat RFP TNO-IMW, Biology 97, NL-2628 VK Delft Department TNO Nutrition & Food Research 10.2001 IC FULL 2, 3, 6, 8, 9: former name: TNO Utrechtseweg 48, PO Box 360 02.2003 PEN FULL biodegradation, kinetics, Nutrition & Food NL-3700 AJ Zeist 06.2003 IC RE-I metabolism, occupational Research: Analytical Div, 06.2004 IC FULL toxicology 07.1999; Tox.Div, 02.2003 RFP new name since 01.2005 TNO Quality of Life TNO Nutrition & Food Research 06.1995 IC FULL 8 new name since 07.1999 Analytical Sciences Division 03.1998 IC FULL 8 TNO, Nutrition & Food Utrechtseweg 48, PO Box 360 NL-3700 AJ Zeist RFP Research TNO Nutrition & Food Research, 05.1999 PEN FULL 2, 9: kinetics left program 04.2000 ILOB Department, 11.1999 PEN FULL 2, 9: kinetics NL-6700 AA Wageningen RFP TNO Nutrition & Food Research 05.1996 PEN FULL 2,3,4,5,6,8,9: metabolism, former name Toxicology Division 09.1996 IC RE-I kinetics until 05.1996 TNO-ITV Utrechtseweg 48, PO Box 360, NL-3700 AJ Zeist 11.1999 IC FULL 2,3,9: metabolism, new name since 02.2003 RFP kinetics TNO Nutrition &Food Res.

14 TEST FACILITY DATE OF INSPECTION STATUS NATURE OF INSPECTION AREA OF EXPERTISE REMARKS

TNO Nutrition & Food Research 09.2000 IC FULL 4, 5 former name until 07.1999 Department of Environmental Toxicology RFP TNO, Nutr.&Food Res., Utrechtseweg 48, PO Box 360 Tox. Div. NL-2600 JA Delft new name since 02.2003 TNO Nutrition &Food Res. TNO-PML, Prins Maurits Laboratory 04.1989 NIC FULL 1 new name since 01.2005 Lange Kleiweg 137, PO Box 45 12.1990 IC FULL TNO Defence, Security & NL-2280 AA Rijswijk 11.1992 IC FULL Safety 11.1995 IC FULL 06.1998 IC FULL 1 10.2001 IC FULL 1, 8 12.2004 IC FULL 1,8 RFP TNO Prevention and Health 03.1999 PEN FULL 8 left program since 04.06 Zernikedreef 9, PO Box 2215 06.2002 IC FULL NL-2301 CE Leiden 08.2005 PEN FULL 8 RFP TNO Quality of Life 10.2006 IC FULL 2,3,6,8,9: biodegradation, former name until 01.2005 Utrechtseweg 48, PO Box 360 kinetics, metabolism, TNO Nutrition & Food NL-3700 AJ Zeist worker exposure Research 10.2008 IC FULL 2,3,8,9: kinetics and new name since 01.2011 RFP metabolism, safety TNO Triskelion BV pharmacology, worker exposure and in-vitro studies TNO Triskelion BV 06.2011 IC FULL 2,3,8,9: safety Former name until 01.2011 Utrechtseweg 48 pharmacology, worker TNO Quality of Life 3704 HE Zeist exposure and in-vitro studies Unilever Research Laboratory 05.1989 PEN FULL 2,8 left program 01.2002 Olivier van Noortlaan 120, Postbus 114 06.1990 NIC RE-I NL-3130 AC Vlaardingen 04.1992 IC FULL 12.1995 IC FULL 12.1998 PEN FULL 08.1999 IC RE-I 2,8 RFP 15 TEST FACILITY DATE OF INSPECTION STATUS NATURE OF INSPECTION AREA OF EXPERTISE REMARKS

Uniroyal Chemical BV 04.1997 PEN FULL 1 left program 04.2004 Ankerweg 18, P.O. Box 58217 11.1997 IC RE-I NL-1040 HE Amsterdam 02.2001 IC FULL 1 RFP Xenobiosis, Free University 07.1996 IC FULL 8 left program 10.2001 De Boelelaan 1083 08.1998 IC FULL 8 NL-1081 HV Amsterdam RFP Xendo Laboratories 08.2000 IC FULL 8 new name since 01.2006 L.J. Zielstraweg 1, NL-9173 GX Groningen 09.2003 IC FULL 8 Xendo Drug Development RFP Xendo Drug Development BV 05.2006 IC FULL 8 former name until 01.2006 Hanzeplein 1, NL-9713 GZ Groningen 09.2008 IC FULL 8 Xendo Laboratories RFP new name since 09.2010 QPS Netherlands BV Yamanouchi Europe BV 10.2003 PEN FULL 8 new name since 08.2005: Biological Development Department 08.2004 IC RE-I 8 Astellas Pharma Europe Elisabethhof 1, NL-2350 AC Leiden RFP BV Zeneca BV, Zeneca Agro Department 10.1997 PEN FULL 6: field phase new name since 01.2001 Voorn 47 07.1999 IC RE-I 6: field phase Syngenta Crop Protection NL-2980 AG Ridderkerk RFP

16 Legends to the abbreviations used:

Areas of expertise of the inspected test facility : 1 Physical-Chemical testing. 2 Toxicity studies. 3 Mutagenicity studies. 4 Environmental toxicity studies on aquatic and terrestrial organism. 5 Studies on behaviour in water, soil and air; bioaccumulation. 6 Residue studies. 7 Studies on effects on mesocosms and natural ecosystems. 8 Analytical and clinical chemistry. 9 Other: specified.

Status of test facilities : IC In compliance with GLP. NIC Not in compliance: Major deviations from the GLP principles have been observed. Procedures in the test facility are such that the reliability of data cannot be ensured. PEN Pending: GLP compliance status not yet decided on. RFP Removed from inspection program.

Nature of Inspection: FULL Full routine GLP inspection including study audit. RE-I Re-inspection following first or routine GLP inspection. SA Study audit on request of other authorities. FACI Facility inspection.

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