Smoking and Pancreatic Cancer Incidence: a & Prevention Pooled Analysis of 10 Population-Based Cohort Studies in Japan Yuriko N
Published OnlineFirst May 21, 2019; DOI: 10.1158/1055-9965.EPI-18-1327 Research Article Cancer Epidemiology, Biomarkers Smoking and Pancreatic Cancer Incidence: A & Prevention Pooled Analysis of 10 Population-Based Cohort Studies in Japan Yuriko N. Koyanagi1, Hidemi Ito1,2, Keitaro Matsuo2,3, Yumi Sugawara4, Akihisa Hidaka5, Norie Sawada5, Keiko Wada6, Chisato Nagata6, Akiko Tamakoshi7, Yingsong Lin8, Taro Takeuchi9, Yuri Kitamura9, Mai Utada10, Atsuko Sadakane10, Tetsuya Mizoue11, Mariko Naito12, Keitaro Tanaka13,Taichi Shimazu5, Shoichiro Tsugane5, and Manami Inoue5, for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan Abstract Background: Detailed prospective evaluation of cigarette former smoking and small cumulative dose of 20 pack-years smoking associated with pancreatic cancer risk in large Asian (PY) were observed only among females, regardless of envi- populations is limited. The aim of this study was to examine ronmental tobacco smoke exposure. Trend analysis indicated this association in a Japanese population, with a particular significant 6% and nonsignificant 6% increases in pancreatic focus on evaluating sex differences. cancer risk for every 10 PYs in males and females, respectively. Methods: We performed a pooled analysis of 10 population- Risk became comparable with never smokers after 5 years of based cohort studies. We calculated study-specific HRs and smoking cessation in males. In females, however, we observed 95% confidence intervals (CI) using Cox proportional hazards no risk attenuation by smoking cessation. regression, and then estimated summary HRs by pooling these Conclusions: This study supports the well-known associa- estimates with a random effects model. tion between smoking and pancreatic cancer and indicates Results: During 4,695,593 person-years of follow-up in potential sex differences in a Japanese population.
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