PILRB Antibody Cat. No.: 26-179
PILRB Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human PILRB.
TESTED APPLICATIONS: ELISA, WB
PILRB antibody can be used for detection of PILRB by ELISA at 1:312500. PILRB antibody APPLICATIONS: can be used for detection of PILRB by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
POSITIVE CONTROL: 1) Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
PREDICTED MOLECULAR 23 kDa WEIGHT:
Properties
PURIFICATION: Antibody is purified by peptide affinity chromatography method.
CLONALITY: Polyclonal
CONJUGATE: Unconjugated
PHYSICAL STATE: Liquid
October 1, 2021 1 https://www.prosci-inc.com/pilrb-antibody-26-179.html Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.
CONCENTRATION: batch dependent
For short periods of storage (days) store at 4˚C. For longer periods of storage, store PILRB STORAGE CONDITIONS: antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Additional Info
OFFICIAL SYMBOL: PILRB
ALTERNATE NAMES: PILRB, FDFACT1, FDFACT2
ACCESSION NO.: NP_038468
PROTEIN GI NO.: 30179915
GENE ID: 29990
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating BACKGROUND: counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.
REFERENCES: 1) Wilson, M.D., (2006) Physiol. Genomics 27 (3), 201-218.
ANTIBODIES FOR RESEARCH USE ONLY.
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