DOCSLIB.ORG

A Centre for Stem Cell and Translational Medicine in the Pearl River Delta

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
A Centre for Stem Cell and Translational Medicine in the Pearl River Delta ADVERTISEMENT FEATURE NATUREJOBS SPOTLIGHT ON GUANGZHOU GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH A centre for stem cell and translational medicine in the Pearl River Delta Just over a decade old, the Guangzhou conviction, GIBH is devoting resources discovery. It is actively seeking external col- Institutes of Biomedicine and Health is to developing cutting-edge technologies laborations and partnerships with scien- exploring new ways to combat disease and to solving important scientific prob- tists and institutes where there is a mutual through conducting vital research. lems in a collaborative environment. interest. GIBH offers commitment, creativ- Accordingly, GIBH is building a new state- ity and opportunity. GIBH seeks individuals he Guangzhou Institutes of of-the-art good-manufacturing-practice who share its vision and enthusiasm for the Biomedicine and Health (GIBH), facility to manufacture clinical-grade future. Positions are available at all ranks Chinese Academy of Sciences, cells, including neural stem cells and in five research programmes (for more in- Twas established in 2003 by the Chinese hepatocyte progenitor cells for human formation, visit http://www.gibh.cas.cn or Academy of Sciences, through collabora- transplantation; these cells will be used http://english.gibh.cas.cn): tive agreements with the Guangdong and to treat diseases of the central nervous Guangzhou governments. The founders system and liver, respectively. • Stem cell and regenerative medicine envisioned a modern institute with a • Chemistry and synthetic biology forward-looking philosophy that would Drug discovery • Infection and immunity transform the research landscape of south- Over the years, GIBH has established a • Public health ern China. GIBH is realizing that vision, as solid reputation through high-profile • Drug discovery pipeline evidenced by its gaining global recognition publications and the development of of its cutting-edge scientific research. innovative drugs. For example, its in- novative drug-discovery platform has Strategic research advanced a number of clinical candidate GIBH has become a first-rate organization drugs for the treatment of cancer and with over 500 dedicated staff members neural degenerative diseases. Two of its and more than 300 graduate students. investigational new drugs were recently The scientists and students are currently certified in 2016 by the Chinese Food engaging in five major fields of inquiry: and Drug Administration, allowing for the stem cell biology, chemical biology, initiation of phase-one clinical trials in infection and immunity, public health China. Its dual focus on original discovery and de novo drug discovery. The GIBH and innovative applications will propel Contact 2016 12 MAY strategy combines both basic and trans- the organization towards even greater lational research in focused areas. This achievements in years to come. E-mail: [email protected] strategy will not only provide a deep un- Tel: 0086-20-32015342, 32015267 derstanding of life and disease, but also Seeking collaborators Fax: 0086-20-32015267 catalyze breakthroughs in the diagnosis The overall vision of GIBH is to serve the Address: 190 Kaiyuan Avenue, Science and treatment of illnesses. Based on this citizens of China and the world through Park, Guangzhou, China, 510530 | NATUREJOBS | | NATUREJOBS 3 Advertiser retains sole responsibility for content.
Load more

Recommended publications
  • APOCB2006-06-001 Study on the Ultrafine Structure of Tumor Cell With
    npg Cell Research (2006) 16:S73-S106 S73npg © 2006 IBCB, SIBS, CAS All rights reserved 1001-0602/06 www.nature.com/cr APOCB2006-06-001 among the four different phases, in which we can see the Study on the ultrafine structure of tumor cell with atomic different character in the protrusion distribution and num- force microscopy ber. Particularly in the nanometer scale, there are some Jie Zhu, Zuodong Wang prominent domains like any field distribution; maybe, it's Department of Applied Physics, College of Science, Northwest the particular structure in the nano-space which related to A&F University, Yangling 712100, China the biologic magnetic or electromagnetic fields. According to the prominent distinguishment character in the AFM Multiple pathways are involved in maintaining the genetic image, we found the credible method to discriminate cells integrity of a cell after its exposure to physical environ- in different cycle or living condition with the AFM and the ments. Although repair mechanisms such as homologous proper techniques. recombination and non-homologous end-joining are Keywords: ultrafine structure; tumor cell; atomic force important mammalian responses to double-strand DNA microscopy; synchronization; cell cycle damage, cell cycle regulation is perhaps the most impor- Correspondence: Jie Zhu tant determinant of physical environments sensitivity. A E-mail: [email protected] common cellular response to DNA-damaging agents is the activation of cell cycle checkpoints. The DNA damage induced by physical environments initiates signals that can APOCB2006-06-002 ultimately activate either temporary checkpoints that permit The effect of solanine on DNA and RNA in the tumor cells time for genetic repair or irreversible growth arrest that Chenfeng Ji1, YuBin Ji1, Shiyong Gao1, Xiang Zou1, results in cell death.
    [Show full text]
  • Global Assessment of Biological Engineering And
    INTERNATIONAL ASSESSMENT OF RESEARCH IN BIOLOGICAL ENGINEERING & MANUFACTURING This study was sponsored by the U.S. National Science Foundation (NSF). Panel Stephen W. Drew, Ph.D. (Chair) Gang Bao, Ph.D. Drew Solutions, LLC Wallace H. Coulter Dept. of Biomedical Engineering 126 Mountain Avenue M Building - 4100M Summit, NJ 07901 Georgia Institute of Technology Atlanta, GA 30332-0535 Christopher J. Bettinger, Ph.D. Kam Leong, Ph.D. Materials Science and Biomedical Engineering Department of Biomedical Engineering Carnegie Mellon University Columbia University Wean Hall 4315, 5000 Forbes Avenue Mail Code 8904 Pittsburgh, PA 15213-3890 |1210 Amsterdam Avenue New York, NY 10027 Madhusudan V. Peshwa, Ph.D. Kaiming Ye, Ph.D. Research and Development Department of Biomedical Engineering MaxCyte, Inc. Watson School of Engineering and Applied Science 22 Firstfield Road, Suite 110 Binghamton University, State University of New York Gaithersburg, MD 20878 PO Box 6000 Binghamton, NY 13902-6000 Other Participants in Site Visits Ted Conway, Ph.D. (Europe and Asia) Athanassios Sambanis, Ph.D. (Asia) General & Age Related Disabilities Engineering Biomedical Engineering and Healthcare (ENG/CBET) Program (GARDE) The National Science Foundation The National Science Foundation 4201 Wilson Boulevard 4201 Wilson Boulevard Arlington, VA 22230 Arlington, VA 22230 Dawn Applegate, Ph.D. (Europe) President and Chief Executive Officer RegeneMed, Inc. 9855 Towne Centre Drive Suite 200 San Diego, CA 92121 WTEC Representatives Patricia Foland (Europe and Asia) Hassan Ali (Europe and Asia) Clayton Stewart, Ph.D. (Asia) WTEC Panel Report on INTERNATIONAL ASSESSMENT OF RESEARCH IN BIOLOGICAL ENGINEERING & MANUFACTURING Final Report on Europe and Asia July 2015 Stephen W. Drew (Chair) Gang Bao Christopher J.
    [Show full text]
  • Hypoproliferative Human NPC Xenografts Survived Extendedly in the Brain of Immunocompetent Rats
    Hypoproliferative human NPC xenografts survived extendedly in the brain of immunocompetent rats Chunhua Liu Guangzhou Institutes of Biomedicine and Health Xiaoyun Wang Guangdong work injury rehabilitation Center Wenhao Huang Guangzhou Institutes of Biomedicine and Health Wei Meng Guangdong work injury rehabilitation Center Zhenghui Su Guangzhou Institutes of Biomedicine and Health Qi Xing Guangzhou Institutes of Biomedicine and Health Heng Shi City University of Hong Kong Di Zhang Guangzhou Institutes of Biomedicine and Health Min Zhou Guangzhou Institutes of Biomedicine and Health Yifan Zhao Guangzhou Institutes of Biomedicine and Health Haitao Wang University of Science and Technology of China Guangjin Pan Guangzhou Institutes of Biomedicine and Health Xiaofen Zhong Guangzhou Institutes of Biomedicine and Health Duanqing Pei Guangzhou Institutes of Biomedicine and Health Yiping Guo ( [email protected] ) Guangzhou Institutes of Biomedicine and Health https://orcid.org/0000-0003-1628-8312 Research Page 1/26 Keywords: ESCs, including H1, its gene-modied cell lines for better visualization, HN4 Posted Date: October 23rd, 2020 DOI: https://doi.org/10.21203/rs.3.rs-92873/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 2/26 Abstract Background: There is a huge controversy about whether xenograft or allograft in the “immune-privileged” brain needs immunosuppression. In animal studies, prevailing sophiscated immunosuppression or immunodeciency is detrimental for the recipients, which results in short lifespan of animals, and confounds functional behavioral readout of the graft benet, discouraging long-term follow-up. Methods: Neuron-restricted human neural progenitor cells (NPCs) were derived from human embryonic stem cells (ESCs, including H1, its gene-modied cell lines for better visualization, and HN4), propagated for different passages and then transplanted into the brain of immunocompetent rats without use of immunosuppressant.
    [Show full text]
  • 年 报 Annual Report 2008
    CHINESE ACADEMY OF SCIENCES Annual Report 08 CHINESE ACADEMY OF SCIENCES 年 报 Annual Report 2008 1 CHINESE ACADEMY OF SCIENCES Annual Report 08 Contents Message from the President 1 Key Statistical Data 4 Strategic Planning 14 Academic Divisions 16 Scientific Research Development 21 Awards and Honors 50 Supporting Conditions 57 Human Resource 65 International Cooperation 68 Domestic Cooperation 72 High-tech Industry 75 Science Popularization 76 Appendix: Directory of the CAS Subordinate Institutions 77 Cover Picture: CAS Member,WuZhengyi, Winner of the National Supreme Science and Technology Award in 2007 2 CHINESE ACADEMY OF SCIENCES Annual Report 08 Message from the President The Chinese Academy of Sciences (CAS) is the nation’s highest academic institution in natural sciences, the supreme scientific and technological advisory body, and the comprehensive research center in natural sciences and high-tech development. It has always been committed, as its historical mission, to providing scientific knowledge, technical support and driving force for sustaining China’s economic prosperity, social harmony, national security and the well-beings of the people. With both new challenges and new opportunities emerging in 2007, CAS held firmly to aiming at the national strategic demands and the world Prof. Lu Yongxiang Member of CAS science frontiers, fostering the value of dedicating Member of CAE to the nation and making innovation for the people, Vice Chairman of the Standing Committee of the National People’s Congress,P.R.China optimizing the scientific and technological layout, President of CAS arranging the research projects with a forward-looking perspective, initiating and conducting the major scientific and technological programs at the national, local or industrial level, promoting the construction of research facilities and platforms, strengthening opening up and cooperation, enhancing the build up of innovative research teams, raising innovation capacity, and promoting technology transfer, thus making coordinated development within all the Academy.
    [Show full text]
  • JMJD3 Acts in Tandem with KLF4 to Facilitate Reprogramming to Pluripotency
    ARTICLE https://doi.org/10.1038/s41467-020-18900-z OPEN JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency Yinghua Huang 1,2,17, Hui Zhang3,17, Lulu Wang 1,2, Chuanqing Tang 1,2, Xiaogan Qin1,2, Xinyu Wu 1,2,4, Meifang Pan1,2,4, Yujia Tang1,2, Zhongzhou Yang1, Isaac A. Babarinde5, Runxia Lin1,2,4, Guanyu Ji 6, Yiwei Lai 1,7, Xueting Xu 1,2,8, Jianbin Su1,2, Xue Wen9, Takashi Satoh10, Tanveer Ahmed 1,2, Vikas Malik 1,7, Carl Ward 1,7, Giacomo Volpe 1,7, Lin Guo 1, Jinlong Chen1, Li Sun5, Yingying Li3, Xiaofen Huang1, Xichen Bao 1,3,11, Fei Gao6,12, Baohua Liu 13, Hui Zheng 1,3,11, Ralf Jauch 14, Liangxue Lai1,3,11, Guangjin Pan 1,3,11, Jiekai Chen 1,3,11, Giuseppe Testa 15, Shizuo Akira10, Jifan Hu 9, 1,3 5 1,7,11,16✉ 1,2,3,11✉ 1234567890():,; Duanqing Pei , Andrew P. Hutchins , Miguel A. Esteban & Baoming Qin The interplay between the Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) and tran- scriptional/epigenetic co-regulators in somatic cell reprogramming is incompletely under- stood. Here, we demonstrate that the histone H3 lysine 27 trimethylation (H3K27me3) demethylase JMJD3 plays conflicting roles in mouse reprogramming. On one side, JMJD3 induces the pro-senescence factor Ink4a and degrades the pluripotency regulator PHF20 in a reprogramming factor-independent manner. On the other side, JMJD3 is specifically recruited by KLF4 to reduce H3K27me3 at both enhancers and promoters of epithelial and pluripotency genes.
    [Show full text]
  • Calendar 2017–2018 the Emblem of the University Is the Mythical Chinese Bird Feng (鳳) Which Has Been Regarded As the Bird of the South Since the Han Dynasty
    The Chinese University of Hong Kong Calendar 2017–2018 The emblem of the University is the mythical Chinese bird feng (鳳) which has been regarded as the Bird of the South since the Han dynasty. It is a symbol of nobility, beauty, loyalty and majesty. The University colours are purple and gold, representing devotion and loyalty, and perseverance and resolution, respectively. The motto of the University is ‘博文約禮’ or ‘Through learning and temperance to virtue’. These words of Confucius have long been considered a principal precept of his teaching. It is recorded in the Analects of Confucius that the Master says, ‘The superior man, extensively studying all learning, and keeping himself under the restraint of the rules of propriety, may thus likewise not overstep what is right.’ (Legge’s version of the Four Books) In choosing ‘博文約禮’ as its motto, the University is laying equal emphasis on the intellectual and moral aspects of education. The Chinese University of Hong Kong Calendar 2017–2018 Unless otherwise specified, the information in this Calendar is accurate as at 1 August 2017. © The Chinese University of Hong Kong 2017 + The Chinese University of Hong Kong Shatin, New Territories Hong Kong Special Administrative Region The People’s Republic of China ' (852) 3943 6000 (852) 3943 7000 7 (852) 2603 5544 8 www.cuhk.edu.hk Produced by the Information Services Office, The Chinese University of Hong Kong Contents Part 1 General Information 1 3 The University 21 The Constituent Colleges 38 Calendar 2017–2018 Part 2 Establishment 45 47 University
    [Show full text]