Elevated Thinking

Colorado Centers of Excellence: Elevated Thinking

Financing Update Bioscience Discovery Evaluation Grant Program Directory Fitzsimons An Exclusive Membership Life Science District Look into Colorado a great place to raise an idea Located in Aurora, Colorado, it’s one of the largest bioscience developments in the country, a place where there’s plenty of room to grow an idea from discovery to market viability. Whether you start in the bioscience incubator or move into a state-of-the art lab facility, everything you need is close at hand. A cluster of talent and resources is available to you, including direct access to the more than 80 core laboratories at the University of Colorado Anschutz Medical Campus – all just steps away. Features throughout the district, such as parks and conference facilities, are designed to inspire collaboration. And a nearby mix of shops, restaurants and homes let your people thrive right along with your ideas.

To Visualize improving the world around us Fisher Scientific, part of Thermo Fisher Scientific, the world leader in serving science, is pleased to have the opportunity to partner with the Colorado BioScience Association and act as primary supplier of laboratory products, safety supplies, equipment, chemicals, reagents and a host of services. Fisher Scientific understands today’s challenging environment and has capabilities that align with CBSA’s strategic goals going beyond just providing products to offering Colorado BioScience Association members access to customized programs to fit their specific needs from start-up to scale-up.

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12_5192 CO State Association Ad.indd 1 4/2/2012 2:18:32 PM The University of Colorado is advancing biomedicine. Opportunities to advance Colorado’s biotech industry through CU’s flourishing research enterprise are plentiful: The Anschutz Medical Campus and Fitzsimons Life Science District in Aurora will be one of the largest • access to CU’s advanced core lab facilities academic biomedical developments in the U.S. • clinical trials – CU faculty are currently testing new when completed, including three affiliated hospitals. drugs in more than 800 trials • sponsored research – CU’s four campuses receive In Boulder, the new Jennie Smoly Caruthers ~$500M of bio-related sponsored research annually Biotechnology Building will house more than 600 • longer-term research collaborations through the faculty, staff and students from nine CU-Boulder Anschutz Medical Campus’ Office of Corporate departments, helping create genuinely groundbreaking Alliances and the CU Biofrontiers Institute biotechnology research via the CU Biofrontiers • technology licensing and new business creation Institute: a collaboration among CU-Boulder, the through CU’s Technology Transfer Office CU Anschutz Medical Campus and the University of Colorado Colorado Springs. CU has a track record of alliances with companies that enhance healthcare outcomes – CU research CU is recruiting world-class interdisciplinary faculty has led to four new approved drugs and numerous for these and other initiatives, like the new Colorado new diagnostic tests and medical devices, and CU Center for Health and Wellness and Department of is nationally prominent for new company creation, Bioengineering at the Anschutz Medical Campus, including biotech firms like Myogen (purchased by and ongoing bioscience and technology efforts on Gilead), GlobeImmune, ARCA biopharma, OPX the Boulder campus. Biotechnologies, SomaLogic, Taligen (purchased by Alexion) and 70 others since 1994. Connect with biotech at CU: Technology Transfer Office Office of Corporate Alliances Biofrontiers Institute All CU campuses CU Denver, Anschutz Medical Campus CU-Boulder David Allen, 303-735-1688 Laura Simon, 303-724-4636 Jana Watson-Capps, 303-492-3588 www.cu.edu/techtransfer www.ucdenver.edu/academics/research biofrontiers.colorado.edu TABLE OF CONTENTS

7 Coming Together Welcome to the Colorado BioScience to Improve Cancer Association’s eighth Treatment edition of Bioscience 25 Colorado, the state’s 9 Colorado At the Center only in depth guide Cancer, Canines and of Biofuels Research and directory to the the Quest for a Cure in bioscience industry. Colorado 26 This publication is an integral part of A Culture of Excellence the Association’s mission to support the 11 and Firsts Colorado bioscience community through Colorado Combats advocacy, resources, and advancement of 29 opportunities for collaboration. With a total Infectious Disease Worldwide Colorado audience of over 15,000, including on-line Clinical & Translational impressions, this publication is one of the Sciences Institute: industry’s greatest voices locally, nationally, 14 and internationally. With Bated Breath Connecting Colorado This issue of Bioscience Colorado highlights solving rare pediatric Communities centers of excellence within the state. As lung diseases we developed this issue, we asked “what 32 makes a center of excellence?” The research 17 Boettcher Investigators our writers and experts have compiled for Treating Asthma and this issue illustrates that there are several 34 components—infrastructure, expertise, other Inflammatory Diseases Medical Center industry connections, and patient outcomes. of the Rockies Each article focuses on a center and examines 20 Committed to the elements that make it truly excellent. exceptional achievement We are proud to say there is a level of Fitzsimons Redevelopment elevated thinking in Colorado bioscience. Authority Bioscience in cardiovascular care We have some of the top research institutions Business Incubator in the country and over 600 bioscience 36 companies led by the best in the industry— 22 Bioscience Discovery creating the vision and drive to succeed. University of Colorado Evaluation Grant That’s why so many great ideas that impact Hospital Academic Program the globe start and grow here. Entrepreneurship As a whole Colorado is an excellent place for 47 bioscience—spread the word! Meets Cardiovascular Innovation Colorado By the Numbers: A 2012 Update on Holli Riebel Colorado’s Growing

Produced by: Bioscience Industry President and CEO Published by: Colorado BioScience Association Colorado BioScience Association Colorado BioScience Association and 216 16th Street, Suite 850 Colorado Office of Economic Development and Denver, CO 80202 International Trade www.CoBioScience.com Cover art concept provided by Pure Brand Communications, (303) 592-4073 illustrated by Bruce Holdeman, 601 Design, Inc.

BIOSCIENCE COLORADO 2012/2013 5 Great ideas that impact theglobe start and grow here.

Bioscience in Colorado ELEVATED THINKING

Colorado is home to over 600 companies in our Life Sciences community that take advantage of our leading research institutions as well as our healthy environment that inspires creativity. This is reflected in high rankings in both business and lifestyle indexes including the healthiest and smartest workforce, in small business research grants, and in significant public-private investments.

Photo by Matt Inden/Weaver Multimedia Group Colorado BioScience Association www.cobioscience.com Colorado Tourism Office Center of Cancer Excellence Coming Together to Improve Cancer Treatment

BY Andrea Pawliczek

Anschutz Medical Campus, Aurora, Colorado

s scientific research into cancer has that cancer treatment could be improved by recognized National Cancer Institute progressed, there has been increasing identifying—through diagnostic testing—the comprehensive cancer center in the state of awareness of its complexity and the most appropriate treatment for each patient. Colorado and contributes to the improvement Adifferences among different cancers, But it also presents a daunting task. First, in cancer care across all phases—from even those in the same organ. According to differences in individual tumors must be discovery and development, to delivery. Patrick Mahaffy, CEO of Clovis Oncology, identified. Then, both the therapies and a company based in Boulder, Colorado, “We diagnostics must be discovered, developed, Surpassing the national averages now think about cancer on the genetic and and tested. This is not something one Providing top quality care to patients is cellular level rather than by organ type.” This researcher, company, or hospital could hope at the heart of the center’s mission; in 2010 way of thinking means that for two people to achieve alone. Despite the challenges, alone the CU Cancer Center saw more than with the same type of cancer—for example the University of Colorado Cancer Center 19,000 new patients. In addition, the Center colorectal cancer—the appropriate course of (CU Cancer Center) has a bold vision for is able to achieve outcomes that substantially treatment might be very different based on 2025—for Colorado to have the lowest cancer surpass national averages in many cases. the specific mutations or characteristics of mortality rates in the country and be able to For example, the five-year survival rate for their individual tumors. serve as a model for other states. stage IV breast cancer is about 40% at the This new understanding offers hope The CU Cancer Center is the only Center versus about 20% nationally. The CU

BIOSCIENCE COLORADO 2012/2013 7 Cancer Center also focuses on total patient care geographically challenging state, making Leveraging resources, from discovery rather than just treatment—a broader focus outreach extremely important.” Recently, the to development that includes prevention and survivorship. University of Colorado Hospital and the Poudre CU Cancer Center’s mission goes far Mark Kochevar, Center associate director for Valley Health System, located in northern beyond providing the best care currently administration and finance, comments, “As Colorado, joined forces to form University of available. The more than 440 doctors and more patients survive longer, it is essential to Colorado Health. The Cancer Center also has scientists of the cancer center are actively provide continued support and care even after formal collaboration with six hospitals across engaged in research to discover new targets intensive therapy may be over.” the state, from Glenwood Springs to Colorado and treatments. They have garnered an The CU Cancer Center is a resource Springs, to help ensure that community average of $522,687 in research funding even for those who might not be able to oncologists are informed about the most recent per capita, totaling over $148 million. travel regularly to the metro Denver area. research, have expert counsel available, and can Although the largest concentration of doctors Kochevar notes that “Colorado is a large and offer patients access to clinical trials. and scientists is on the Anschutz Medical Campus in Aurora, researchers are spread across the state including on the campuses of CU Boulder, Colorado State University in Fort Collins, and National Jewish Health in Denver. They are all supported by the CU Cancer Center’s 13 shared resources— including biostatistics, genomics, tissue bio- banking, and flow cytometry. This provides scientists with equipment, expertise, and facilities that are vital to research, but which would be too expensive to maintain in a single laboratory. Even after a valuable discovery has been made, there is still a long road to having a marketed drug or diagnostic tool. Bioscience companies such as Clovis Oncology often lead this development stage. “There is an excess of discovery compared to the current capacity for development,” notes Clovis CEO Mahaffy. “Moreover, the skill set to develop a drug is in many ways different than that needed for drug discovery.” Clovis helps bridge this gap by pushing promising drugs through the development process. Centers such as the CU Cancer Center still play an extremely important supporting role at this stage by serving as sites for clinical trials. In fact, 27% of new patients at the Center participate in clinical trials, and it will serve as one of the clinical trial sites for an important phase I/II lung cancer trial of Clovis’ CO-1686, an oral epidermal growth factor receptor (EGFR) inhibitor. Gone are the days when anyone talks about a single cure for cancer. Rather, the complexity and heterogeneity of cancer Full Service dCRO require multiple types of work to improve outcomes. This work ranges from basic • Clinical Development • Regulatory & Strategic Development scientific research, to drug and diagnostic • Drug Development • Post Approval Programs & Registries development, to patient care. To make • Medical Device Development advances in a task so complex takes the efforts of physicians, researchers, companies—and centers like the University Research Triangle Park (HQ) | Boulder | Overland Park | Zurich of Colorado Cancer Center where key Munich | Tel-Aviv | New Delhi | Buenos Aires | Sao Paulo | Lima clinipace.com resources can come together.

8 2012/2013 BIOSCIENCE COLORADO Center of Cancer Excellence Cancer, Canines and the Quest for a Cure in Colorado

BY Andrea Pawliczek

tepping into the waiting room at the attempts to control systemic disease. On the Colorado State University (CSU) chemotherapy front, veterinary oncologists Veterinary Teaching Hospital campus, are faced with a relative paucity of data Sit might seem much like the reception compared to that in human patients. Only two area in any medical office. Patients’ families drugs and one vaccine are approved to treat wait—some looking nervous while others cancer in animals. Much of current treatment pass the time reading or playing with smart involves repurposing human drugs, usually the phones. Doctors in white coats and nurses in relatively less expensive generic medications. scrubs stride through purposefully, sometimes stopping to update families. Then, a patient New treatments for people— returning from chemotherapy comes trotting and their best friends out on a leash, wagging its tail, anxious to be In this challenge, there also lie several reunited with its owner. This is a different kind opportunities. Many pets with cancer of medical facility. may be eligible for well-managed clinical The CSU Animal Cancer Center (ACC) at investigations of new therapeutic agents the CSU Veterinary Teaching Hospital treats Golden retriever Jasper was treated at the CSU or devices. At any given time, the ACC dogs and cats suffering from cancer—one of Animal Cancer Center. is conducting 10 to 15 clinical trials for the most common and devastating diseases therapies that bioscience companies hope will affecting adult pets today. World-renowned in owners per year. Companion animals receive eventually be used in humans. the field, the Animal Cancer Center sees 1,500 the best possible care, along with support for Dr. Rodney Page, ACC director, explains new patients a year, 25% of whom travel here, their owners. that the center’s dual missions are “providing with their human companions, from outside of Veterinary oncologists here use many of top quality care to companion animals as well Colorado. The center is also a training ground the same tools as those treating humans to as helping to advance new therapies being for eight to 10 residents and fellows studying combat the cancers that afflict their patients— developed for people.” These missions go veterinary oncology, and provides over 3,000 surgery to remove localized tumors, radiation hand in hand; ‘human’ therapeutic companies phone consultations to veterinarians and pet to shrink tumors, and chemotherapy in conducting trials provide financial support to the center, making it possible for pet owners with financial constraints to get treatment for their best friends. Moreover, the National Cancer Institute has recognized that dogs are an excellent model for many human cancers due to genetic similarities, similar cancer types, and similar responses to treatment. Clinical trials in dogs can enable the evaluation not only of the efficacy of a particular drug, but also provide important information on optimal dosing and scheduling, safety, and the correlation with biomarkers and imaging. Page would like to see research collaborations expand further to the point where they become financially self- sustaining One company looking to capitalize on CSU Animal Cancer Center, Fort Collins, Colorado animal-human synergy is VetDC, based in Fort Collins. VetDC was established as a spin-off

BIOSCIENCE COLORADO 2012/2013 9 of CSU Ventures, an organization designed not to pursue further human development. was treated for a rapidly growing form of to commercialize promising research coming Dr. Thamm brought the opportunity to cancer called hemangiosarcoma, praises the out of CSU. Dr. Terry Opgenorth and others the attention of VetDC and eventually the treatment that his pet received. “The most at the university recognized an untapped company was able to negotiate a license for important thing to me was the great care opportunity to approach human health the use of the drug, VDC-1101, in animal everyone [at the ACC] provided to Jasper. companies that were conducting research at cancer. Each doctor and nurse was superb, which CSU to obtain licenses to implement similar Licensing a molecule already under gave me confidence that he was receiving programs for veterinary use. “In discussions development gave Gilead a “huge head start” the best treatment available. Ultimately, with many of these companies, very few have versus developing a drug from scratch notes this gave me additional high-quality the bandwidth, resources, or strategic focus Roy. VDC-1101 already had a complete months with my dog.” Vincent goes on to to adequately develop their programs for package of animal data, and was aggressively say “I also appreciate the fact that Jasper veterinary applications,” says Dr. Opgenorth. seeking funding to pursue FDA approval. might help [veterinarians and researchers] “That’s where VetDC comes in.” The company is now looking to in-license learn something that advances medical Steven Roy, a veteran of the other drugs since many human-focused understanding, which could allow others pharmaceutical industry, was brought in to biopharmaceutical companies have programs more time with their loved ones—human or serve as CEO, and help establish and advance they are not actively pursuing that could canine.” VetDC’s product pipeline. be of tremendous benefit to animals. Roy In time, the research currently underway In one example, a clinical trial conducted believes VetDC is in an ideal position to at the CSU Animal Cancer Center and at the Animal Care Center gave VetDC a bring in other opportunities that may arise. companies like VetDC may lead to even more unique opportunity. Dr. Douglas Thamm, a “The location near and collaboration with treatment options and more success stories. medical oncologist at the center, was working the Animal Cancer Center is a significant Although currently available treatments are on a trial for a promising new anti-cancer competitive advantage, since veterinarians limited, the center and its staff of highly compound being studied in pet dogs with and researchers at CSU are at the leading trained veterinarians have much to offer pet lymphoma. Although the drug showed edge of companion animal research,” he says. owners and bioscience alike. “I want more strong efficacy in reducing the sizes of Talking to any pet owner, the value of this people to know we’re here,” says Page. “Both tumors in many of the treated dogs, Gilead innovative center becomes apparent. Chris to treat animals and support partnerships in (the company developing the drug) chose Vincent, whose golden retriever, Jasper, drug development.”

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10 2012/2013 BIOSCIENCE COLORADO Center of Infectious Disease Excellence

Colorado Combats the Spread of Infectious Disease Worldwide CDC division based in Fort Collins teams with bioscience firms to develop better vaccines

BY Andrea Pawliczek

overarching goal is to protect the nation from bacterial and viral infections spread by these vectors. Toward this end, the DVBD engages in a variety of activities—from the development of preventative strategies and technologies, to disease management, to confirming and tracking outbreaks when they do occur. According to Emily Zielinski- Gutierrez, a behavioral scientist there, “A large part of our work is in collaboration with state and local health departments and international governments and organizations.”

A new vaccine for dengue fever Due to the nature of its work, the DVBD has many opportunities to collaborate and interact with biotechnology companies. One such instance occurred in the development of a dengue fever vaccine, exclusively Aedes aegypti mosquito. Photographer James Gathany, Centers for Disease Control licensed by Inviragen, a company formed to develop vaccines and also based in Fort ector borne diseases —dengue fever, world will be introduced. The encroachment Collins. The symptoms of dengue fever, Lyme disease, the plague—are not of the suburbs into wooded areas increases a disease spread by infected mosquitoes, top of mind concerns for most people potential contact with certain vectors such mirror that of a bad flu—high fever, fatigue, Vin United States. Despite this relative as ticks. The Center for Disease Control bone and body aches. In most cases, those lack of concern, these illnesses represent a and Prevention’s Division of Vector-Borne afflicted are able to recover, however a real—and in some instances increasing— Disease (DVBD) is charged with mitigating percentage of cases develop into the more risk to people in this country. and managing these risks. severe dengue hemorrhagic fever (DHF), Some aspects of modern life have The DVBD addresses diseases primarily which can be fatal. Most cases occur actually increased the risks of vector carried by three different vectors: ticks, in tropical regions (dengue is currently borne diseases. International travel and mosquitoes, and fleas. Based in Fort Collins, endemic in Puerto Rico), but the disease can commerce increase the possibility that Colorado, with additional offices in San occur in some subtropical regions. In 2009 infected vectors from other parts of the Juan, Puerto Rico, and Atlanta, the agency’s and 2010, nearly 100 cases of dengue were

BIOSCIENCE COLORADO 2012/2013 11 reported in Key West, Florida. Inviragen became aware of DVBD Many other companies throughout research into a new dengue vaccine through contacts at Colorado State University. Colorado are also working to According to Dan Stinchcomb, Inviragen’s improve the diagnosis and treatment CEO, the vaccine was an attractive licensing opportunity for several reasons. The DVBD of various infections. researchers had started with a weakened version of the DEN-2 virus, demonstrated Microphage (Longmont) – Developed the FDA-approved KeyPath test that can identify to be safe in previous phase I trials in the contagious staph bacteria MRSA within five hours humans. They then replaced key structural genes with those of the other types of PeptiVir (Aurora) – Developing a synthetic peptide-based vaccine platform with lead dengue (DEN-1, DEN-3, and DEN-4) product PVI-1000 that has the potential to be a universal flu vaccine because, to be effective, a dengue vaccine must confer immunity to all four types InDevR (Boulder) – Collaborating with GE with DARPA funding to develop a device that of the virus. “[The researchers] had done could rapidly identify flu and other infectious diseases at the point of care genetic mapping that gave us confidence that replacing the structural genes would not impact the safety of the original attenuated The company recently completed a phase I strong signal of efficacy. Inviragen has virus,” Stinchcomb says. trial in which DENVax was shown to be safe already begun enrolling patients in a phase Since executing an exclusive license and well tolerated. Moreover, the vaccine II trial where the vaccine will be tested with the CDC, Inviragen has continued to induced neutralizing antibodies to all four in patients on three continents across a develop the vaccine, now called DENVax. types of dengue in study participants, a wider age range and including people

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5119 Visit Denver: 1/2PG 4C Collage ad for Biosci- 7.5”w x 4.813”h trim ence Colorado previously exposed to dengue. “We’ve had in rice alleviates any safety concerns that fraction of the activity going on inside the opportunities for continued collaboration might come with a bacterial platform. It’s DVBD to both manage today’s diseases with DVBD scientists on two fronts,” also potentially very cost-effective. While and prepare for potential future threats— Stinchcomb notes. “They are characterizing many homeowners are concerned about internally and in collaboration with other the viruses in the vaccines to ensure they Lyme disease, price sensitivity hovers government agencies and companies. In are safe. Additionally, they are researching around $100 per season, making economical other words, this agency spends every day opportunities to improve the vaccine for a production important.” thinking about vector-borne diseases so potential second generation product.” Researching better vaccines is just a most of us will never have to.

Tracking and preventing Lyme disease Another important program at the DVBD is focused on Lyme disease, the Setting the Standard for Medical Waste Disposal most common vector-borne disease in the United States with about 30,000 cases Celebrating 20 Years of Service reported in 2010. The DVBD has multiple programs to track and prevent Lyme Convenient, timely, a ordable service. disease. A core aspect of these programs No ne print or hidden agendas. is to prevent contact with infected ticks in Gold Star Award and A+ rating from the yards where people spend much of their BBB reects ethical business practices. outdoor time. The DVBD is also working on a unique Local, woman owned company and vaccine for Lyme disease in collaboration industry experts. with Ventria Biosciences of Fort Collins. The Join your fellow CBSA members and goal of this program is to vaccinate white- become a partner to reduce our carbon footed mice against Borrelia burgdorferi, footprint utilizing an environmental and the bacteria that causes Lyme disease, so sustainable disposal solution. the mice are unable to transmit the bacteria Together we can make a di erence! to ticks that could later infect humans (vaccinated mice could also kill bacteria Phone: 303 794-5716 Fax: 303 763-2339 in ticks already infected). To vaccinate Email: [email protected] Web: www.coloradomedicalwaste.com mice, researchers propose placing the vaccine in infbaito@c thatolorado the micemedi calwawouldst eeat..com The collaboration is currently funded by a phase II SBIR grant, awarded after successful progress on the project with a phase I grant. The vaccine under development began with the same molecule as a Lyme disease vaccine for humans that used to be on the market but is no longer available. Through this public/private sector collaboration, DVBD scientists are doing laboratory testing to show that the vaccine is effective in conferring immunity to mice, and working to modify the vaccine so that it is effective when administered orally. In turn, Ventria is working to optimize production of the vaccine using its ExpressTec protein expression platform, in which recombinant proteins are grown in rice. According to DVBD Chief of Microbiology and Pathogenesis Activity Barbara Johnson, Ventria has proved an ideal partner for several reasons beyond its geographic proximity. “Making the vaccine

BIOSCIENCE COLORADO 2012/2013 13 Center of Respiratory Excellence With Bated Breath Children’s Hospital Colorado and SomaLogic work to solve rare pediatric lung diseases

BY Jeanne McAdara-Berkowitz, PhD

s the director of the Children’s Breath- ing Institute and Interstitial Lung Disease Program at Children’s Hospital AColorado, Robin Deterding, MD, has taken on a daunting challenge: she wants to figure out how, at a molecular level, to recognize, treat, and predict outcomes for a group of related but distinct pediatric lung diseases. Some are so rare they don’t even have their own names. Individually, these “rare diffuse lung diseases” may show up in only a handful of patients, but taken together they affect a significant number of children, although the exact prevalence of these diseases is not known. The problems with managing rare diffuse lung diseases are multifold. Some arise out of genetic deficiencies in production of lung surfactants; others are immune disorders in which the body inappropriately attacks its own lung tissue; and the causes of yet others are still unknown. The symptoms often manifest from birth, meaning that tiny newborns or young children must undergo an uncomfortable, invasive, costly workup that may or may not yield useful insight into their disease. In infants, bronchoalveolar lavage—washing and collection of fluid from Children’s Breathing Institute and Interstitial Lung Disease Program at Children’s Hospital the lungs—yields at best a few milliliters of Colorado, Robin Deterding, MD, with patient. fluid for testing. Lung biopsy is common. And invasive procedures may need to be company. Through an unusually flexible and is the Slow Off-rate Modified Aptamer, or done throughout a child’s life in order to collaborative partnership, Deterding and her SOMAmer™—a synthetic protein-capture monitor disease progression and response to team are using SomaLogic’s technology and reagent that can be engineered, in modular treatment. Without a clear understanding of expertise to analyze bronchoalveolar lavage fashion, to bind with high sensitivity and disease etiology, treatment choices are based samples from pediatric patients at Children’s specificity to a particular protein of interest. more on art and past experience than on solid Hospital Colorado. Ultimately, the goal is to Built from modified nucleic acids instead scientific evidence. identify patterns of protein expression that of amino acids, SOMAmers essentially Deterding aims to change that, with differ between healthy and diseased lungs for represent a human-engineered improvement the help of a pilot-stage collaboration use in clinical management. over nature’s protein-capture reagent, the with SomaLogic, a Boulder, Colorado, At the core of SomaLogic’s technology antibody.

14 2012/2013 BIOSCIENCE COLORADO Summer 2013

Reserve your advertising space today in the 2013 edition Children’s Hospital Colorado, Aurora Colorado the research directions set by Deterding and other research clinicians at Children’s SomaLogic has developed more than Hospital Colorado. 1,000 distinct SOMAmers to date, each “We’re learning that, when we work Total audience of over 15,000 of which binds a different protein target with bright, passionate, dedicated clinicians bioscience, economic development, critical to normal and disease biology. like Robin, and we give them and their legislative, university and industry The SOMAmers are used together in teams access to our resources without a leaders the SOMAscan™ assay, to conduct lot of predefined questions, they end up 8th year in publication highly multiplexed protein detection and discovering all kinds of things none of us measurement. ever expected,” says Stephen Williams, MD, Complete directory of every bio- PhD, SomaLogic’s chief medical officer. science company in the state COLLABORATION SPEEDS UNDERSTANDING “These researchers know best what they From Deterding’s perspective, access need out of a technology and can recognize In-depth industry analysis and inter- to SomaLogic’s technology and scientists quickly when something surprising and views is enabling a profound acceleration in the exciting is happening. The end result can pace of her research to understand rare lung be a much more direct path from discovery One of the most respected industry diseases. to development to validation than any publications “At birth we have maybe a teaspoon diagnostics company might have designed of lavage fluid to work with,” she says. on its own.” “SomaLogic can detect 1,000 different The SOMAscan research program proteins in a drop of that fluid, and tell us at Children’s Hospital Colorado isn’t how their expression levels are different limited to rare diffuse lung disease; from one patient to another. That’s going Deterding is working with another team of to make a huge difference in the not-too- investigators—including Edith Zemanick distant future.” MD, Kirk Harris, PhD, and Brandie Wagner, The benefits of the collaboration are not, PhD—to analyze blood and lung fluid of course, just on the part of Deterding’s samples from cystic fibrosis (CF) patients, research program. If, in the future, her again hoping to tease out differences in team’s collaboration with SomaLogic is protein expression that could predict which successful in using SOMAscan to develop patients will respond best to different reliable diagnostic signatures for pediatric treatments. 303-592-4073 lung diseases, the biggest beneficiaries will “CF is a single disease, but each www.CoBioScience.com be patients. individual kid is still different,” says “If we had these tools, we could Deterding. “We know that with different spare kids the repeated, invasive workup. CF treatments, there are responders and Great value for your SomaLogic’s technology could potentially nonresponders, but right now we have no replace all of that and help us get to way of knowing who’s who until we’ve advertising budget! treatment faster,” says Deterding. tried it empirically. If we can work with SomaLogic also stands to benefit from SomaLogic to develop a rapid diagnostic

BIOSCIENCE COLORADO 2012/2013 15 Center of Respiratory Excellence signature from blood, we can skip the treatments that aren’t going to work, and get patients on effective ones right away.” Children’s Hospital Colorado provided the ideal environment for this research. It is a leading referral center for rare pediatric lung disease, the largest CF center in the country, and also has strong multidisciplinary programs in clinical care and translational research for cystic fibrosis, asthma, and lung diseases of prematurity. In addition to active patients, Children’s houses an extensive, state-of-the-art clinical research laboratory with samples from Colorado and all over the world. “When you think about Children’s Hospital Colorado’s research focus, talent, and resources, it was a natural fit for this work,” says Williams.

Technical know-how meets clinical research Deterding and her team are already meeting with some early successes. She says they have identified the potential involvement of proteins not previously associated with lung disease. That could provide interesting clues no one had considered previously. While the research represents an exciting potential real-world application of proteomics (large-scale study DENVER SOUTH: of proteins), in the end, its success will COLORADO’S CORPORATE CAPITAL hinge on the clinical utility of the findings. “It’s not enough to look at the expression With a bioscience workforce almost 4,000 strong, Denver South is a patterns and say ‘isn’t that interesting,’ ” growing force in the bioscience community. Companies like Baxter says Deterding. “The key will be to get this Healthcare Corporation, formerly Baxa, have beneﬁ ted from our to the clinic, and that’s why the collaboration highly-educated workforce for years. is so important. They have the technological And, since almost 30% of corporate earnings in Colorado can be traced to know-how, and we have the clinical research companies located in Denver South, it’s easy to see why we are home to capabilities.” more corporate relocations than anywhere in the region. For SomaLogic’s part, they see this collaboration as a model for future To learn more about how the world-class Denver South workforce can Fort Collins programs, in a variety of therapeutic help grow your bioscienceEstes Park business, call or visit us online today. areas, including neurodegenerative and 303.792.9447 | www.denversouthedp.org25 gastrointestinal diseases—and not only the Longmont

76 common ones. Boulder “We think this approach holds the key for anyone with rare or mechanistically Golden Denver 70 70 complex diseases,” says Williams. 225 AuroraAurora

Greenwood Village Centennial Meanwhile, back in the clinic,

Lone Parker Deterding’s excitement about the Tree Breckenridge collaboration’s potential is unmistakable. Castle Rock

25 “It’s so frustrating how limited our knowledge about these diseases is right now,” she says. “But I just know that, in five www.denversouthedp.org years, we will look back and be absolutely

COLORADO’S CORPORATE CAPITALColorado Springs amazed at how far we’ve come.”

16 2012/2013 BIOSCIENCE COLORADO Center of Respiratory Excellence National Jewish Health Teams with Industry to Treat Asthma and other Inflammatory Diseases

BY Jeanne McAdara-Berkowitz, PhD

espite the availability of a wide range of the Weinberg Clinical Research Unit, at biomarkers, aspirin intolerance, and of treatments, recent epidemiological National Jewish Health (NJH) in Denver, drug development, led him to a recent studies have shown that greater than Colorado. His clinical practice includes collaboration with Boulder, Colorado-based D50% of patients taking multiple several thousand patients with asthma, N30 Pharmaceuticals, aimed at finding new asthma medications still have poorly allergy, sinus disease, allergic eczema, medicines for asthma. controlled disease. Patients with uncontrolled and primary immune deficiencies. Katial’s N30 Pharma is taking a novel approach asthma face higher risks of exacerbations, involvement in a number of asthma-related hospitalizations, ER visits, and rescue research programs, including inflammation, Rohit Katial, MD, National Jewish Health interventions, not to mention serious long- term health consequences. Thus, the search for new and better asthma medicines continues. “Asthma is a disease with significant heterogeneity,” says Rohit Katial, MD. “Some patients do very well with currently available inhaled medications, but others continue to have significant symptoms even with high-dose oral corticosteroids. Clinical trials studying new therapeutics provide some hope for the future for such patients.” Katial is the director of the Allergy & Immunology-Adult Program, and the director

National Jewish Health campus in Denver, Colorado.

BIOSCIENCE COLORADO 2012/2013 17 to this problem. Their product development A steroid-free alternative “Throughout its history, National Jewish program is centered on modulating the nitric “Our compounds provide a potential has continuously been on the cutting edge of oxide (NO) signaling pathway—specifically, new therapeutic class for inflammatory treatment and research to advance the science they are developing therapeutic candidates respiratory disease,” says Janice Troha, of respiratory disease,” says Katial. “In this that inhibit the enzyme S-nitrosoglutathione N30 Pharma’s vice president of clinical case, we have the deep clinical research reductase (GSNOR), in turn increasing the development and regulatory affairs. experience and patient population of difficult- body’s circulating pool of the molecules “In animal models they exhibit potent to-treat asthma patients that makes us an ideal S-nitrosoglutathione. S-nitrosoglutathione bronchodilatory and anti-inflammatory partner for N30 Pharma’s research.” is a physiological precursor for the properties. We also have evidence that For Katial, working with a small, local signaling molecule, NO, and changes in its N6022’s effects would likely be additive company on such an early-stage therapeutic concentration produce downstream effects on to beta agonist treatments, and provide an has been a refreshing and invigorating numerous aspects of physiology, including alternative to the steroid anti-inflammatory experience. Says Katial, “the relationship with cellular receptor function, inflammation, pathway in asthma patients.” N30 Pharma provided an opportunity for an vascular and airway smooth-muscle tone, and As exciting as these predictions are, unusual amount of face-to-face interaction and breathing control. there is a long road between early evidence direct collaboration. We were able to provide Given the properties of N30 Pharma’s and clinical outcomes. Having successfully input on the best approaches to study design GSNOR inhibitor (GSNORi) compounds, brought the compound through phase I, N30 and appropriate endpoints—something we the company’s clinical program is Pharma turned to Katial and National Jewish don’t often get to do when working within initially aimed at the treatment of acute Health for help with the next step in N6022’s the bureaucracy of the large pharmaceutical inflammatory lung conditions, such as journey, a phase IIa clinical trial. companies.” asthma and COPD. The company’s lead Founded in 1899, NJH is known worldwide Because N6022 is a completely new candidate, N6022, is among the most potent for treatment of patients with respiratory, drug, with a novel mechanism of action, a in its portfolio of GSNORi. cardiac, immune, and related disorders, and cautious approach to clinical trial design for groundbreaking medical research. was warranted. With valuable input from

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18 2012/2013 BIOSCIENCE COLORADO N30 Pharmaceuticals

N6022 in adult patients with mild asthma. trials prove favorable, N30 Pharma hopes to “The strategy we arrived at was to use the develop N6022 for inhaled delivery and other, IV formulation as a ‘pathfinder’ drug, since related compounds for oral administration. it gave us the opportunity of a rapid path into “In the end, our goal is to help people the clinic,” says Troha. “We and the NJH with asthma live their lives in ways similar to investigators felt that this was important for an those without,” says Katial. “They should be entirely new class of drugs that had not been able to enjoy work, personal activities, and tested in patients before.” other endeavors without limitations from their Data collection was completed late in underlying disease. That’s why this work is so 2011 and analysis is under way. While NJH important.” investigators and N30 Pharma couldn’t For its part, N30 Pharma recognizes reveal any specific results at the time of this great value in the time, input, and effort writing, they did note an interesting pattern of Katial and NJH have invested in this response, with sustained effects for more than collaboration. Troha says they see this early 24 hours after a single IV injection, consistent study as just the beginning of an ongoing with previous preclinical results. collaboration that will undoubtedly yield long-term gains. Katial and the other trial investigators, The next steps “When you are developing compounds N30 Pharma opted to test the intravenous Development will depend on the outcome in clinical research, building long-term (IV) formulation of N6022, and designed of this study, but Katial and N30 Pharma relationships with thought leaders who can the study as a phase IIa, double-blind, are currently working together on plans for provide critical research and clinical insight, randomized, placebo-controlled, two- stratifying patient selection and identifying as well as knowledge about how each system period crossover study to evaluate the responders in asthma and COPD. Should the works operationally, is one of the keys to bronchoprotective effects of a single dose of final results of the analysis and additional success.”

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BIOSCIENCE COLORADO 2012/2013 19 Fitzsimons Redevelopment Authority Bioscience Business Incubator Fueling Economic Growth and a Collaborative, Thriving Community

BY Casey Demchak Nearly 12 years after its inception, the authority’s vision has become a reality—and the prospect of even greater growth looks bright. Some of he Fitzsimons Redevelopment Authority the prominent Colorado companies that began in the incubator include (FRA) had a bold vision when it opened its Myogen, Accera, Globelmmune, and ValveXchange. bioscience incubator in July of 2000. The Today, the incubator is home for 35 companies in different stages T goal was to provide office and lab space of development. Several of them show great promise. Just some of the within the FRA’s 60,000 square-foot Bioscience companies industry leaders have their eyes on are Beacon Biotechnology, Park Center that would foster a collaborative environment among startup Mitomics, Sharklet Technologies, and Oberon FMR. bioscience companies. While FRA’s vision remains the same, the authority has made some With access to University of Colorado core labs, business notable upgrades over the years to its incubator services. A second building, development assistance, shared scientific equipment, conference rooms, Bioscience East, was added in 2005, allowing maturing companies to move and other essential services, the hope was that early-stage companies to larger space. A 37,000 square-foot accelerator building attached to the would become successful organizations that create jobs and help drive the Bioscience Park Center will open in July, 2012. Business development growth of Colorado’s bioscience industry. services have been enhanced, access to CU core labs has become even easier, and additional scientific equipment has been purchased. Future plans include the construction of more buildings in the science and technology park that will enable incubator companies to move into expansive, long-term space. Having established companies in close proximity to incubator startups will further promote the collaborative atmosphere that makes the Colorado Science & Technology Park at Fitzsimons an important hub in the overall growth of Colorado’s bustling bioscience industry.

20 2012/2013 BIOSCIENCE COLORADO Successful Graduate Companies Currently Incubating

AktiVax Life BioScience, Inc. Company entered Graduation Avidity, LLC Light Labs Myogen 1998 2000 Barofold, Inc Lohocla Research Corp Accera 2002 2004 Beacon Biotechnology MBC Pharma, Inc. GlobeImmune 2002 2005 BioAMPs International LLC Mitomics Inc Evolutionary Genomics 2003 2007 Biodesix Mosaic Biosciences, Inc. VitroDiagnostics 2002 2007 BodySync, Inc. NanoTrans Technologies Inc. Taligen Therapeutics 2004 2011 CID4 Oberon FMR ValveXchange 2008 2011 Clarimedix OncoTherix ARCA Biopharma 2004 2010 ClinImmune PhosphoSolutions, LLC Crestone PolyNEW, Inc. Incubator Statistics CU Dermatopathology Qgenta Consultants Shape Ophthalmics LLC • 35 current companies (academic & commercial) ELISA Tech Sharklet Technologies located in Fitzsimons Redevelopment Authority EndoShape, Inc. Taiga Biotechnologies, Inc. buildings Fluonic Inc. Telsano • 59 total current and past companies that occupied FRA FluTrends International, LLC Touch of Life Technologies buildings (academic & commercial entities) since iCanDxRx, LLC UCD-Technology Transfer 1998 iC42 Bioanalytics/CU Dept of Office • 52 total current and past Incubator clients Anesthesiology Work, Education and Lifelong • 9 successful graduates (still active or acquired) ICV Rx Learning Simulation • 578 jobs created* IHC Tech (WELLS) Center • $659 million Funds raised by incubator clients (does Isogenis, Inc. XNTERA Corporation not include acquisition amounts) * (Companies with available data)

For more information visit www.FitzScience.com or contact Vicki Jenings at [email protected]

Rendering of the Bioscience Park Center with expansion.

BIOSCIENCE COLORADO 2012/2013 21 Center of Cardiac Excellence University of Colorado Hospital Academic Entrepreneurship Meets Cardiovascular Innovation

By Casey Demchak Dr. Stephen Liggett of the University of The creation of ARCA Biopharma is a Maryland. This mix of academic discovery great example of how discovery science at here is an important business dynamic leading to the creation of a growing UCH can result in the birth of a Colorado growing stronger every day in Colorado enterprise also resulted in the formation of biotech company. “Following the usual that plays a vital role in cardiovascular Myogen Inc., which Dr. Bristow co-founded discovery trajectory, when we have a target T treatment innovation. It centers on with Leslie Leinwand of CU Boulder. There, or compound within the pharmacogenetic the interweaving of academic research and he served as chief science and medical universe we think is protectable from an entrepreneurial passion that leads to the officer and director until the company was intellectual property standpoint, we disclose formation of companies changing the face of acquired by Gilead Sciences in 2006. it and submit a patent,” says Dr. Bristow. medical device and drug development. The relationship between University Michael Bristow, MD, PhD, professor of medicine at the University of Colorado of Colorado Hospital (UCH) and ARCA Health Sciences Center and President and CEO of ARCA Biopharma. Biopharma exemplifies this vibrant interplay. Michael Bristow, MD, PhD, is professor of medicine at the University of Colorado Health Sciences Center and president and CEO of ARCA Biopharma, which he co-founded in 2004. ARCA’s mission is to develop cardiovascular drugs that uniquely act through important genetic variants in drug targets, a process known as pharmacogenetic targeting. ARCA is currently developing Gencaro,™ a drug intended to help prevent atrial fibrillation and treat chronic heart failure. All of the discoveries related to Gencaro,™ and other compounds in the ACRA pipeline, originated in Dr. Bristow’s lab at UCH or in the laboratory of a close scientific and NIH grant collaborator,

22 2012/2013 BIOSCIENCE COLORADO “We then license the patent from UCH to Academic entrepreneurs ARCA through the university tech transfer One aspect of the academic-entrepreneur office. From this point, the R&D and model that makes UCH a regional center commercial development of the compound of excellence is its willingness to allow is in the hands of the company, and the academic physicians to remain professors role played by UCH ends. However, they while also wearing the hat of CEO in a still retain royalties from product sales and company they founded. What makes this maintain an equity stake in the company.” work are well-defined standards that assure This academic–entrepreneur model ethical lines are not crossed and conflicts of benefits UCH through product sale royalties interest between UCH and companies like which create additional revenue streams ARCA are avoided. that lead to new research and discovery. Not every university hospital around Companies that form from discovery at the country allows for physicians who have UCH gain because they don’t have to build dual missions. However, Peter Buttrick, MD, freestanding laboratories or other facilities head of the Division of Cardiology at UCH, for work that can be more easily contracted believes the academic-entrepreneur model Peter Buttrick, MD, Head of the Division of through UCH. In addition, the state of can be very advantageous. Cardiology at UCH. Colorado reaps economic rewards through “UCH has a very enlightened tech greater job creation and the expansion of our transfer office and excellent relations with atrial fibrillation. bioscience community. the state of Colorado,” reports Dr. Buttrick. Although a lot of hospitals perform such “We are always eager to develop sponsored ablations, Dr. Buttrick believes UCH is at research agreements with companies the cutting edge of this technology. “We formed through discovery at UCH because can perform ablation procedures better than it can lead to economic and quality of life most because of advanced technology that advancements that benefit our citizens, the enables us to approach electrical arrhyth- university and the growth of our statewide mias very effectively.” Dr. Buttrick goes bioscience sector.” on to say, “Five years ago success rates for While support of academic entrepreneurs atrial fibrillation ablation was in the 50% to is one hallmark of UCH’s contribution to the 60% range, but today we can report success bioscience community, their advancements rates of about 85%.” in cardiovascular care are also central to its Advancements in the placement of recognition as center of excellence left ventricular assist devices (LVAD) are in Colorado. another cornerstone of UCH’s cardiovascular UCH is the only hospital in the region program. Each year life-saving devices are to perform heart transplants, and one of two implanted in about 30 patients. During an Colorado hospitals—along with Medical LVAD procedure, a tube is placed in the Center of The Rockies—chosen to perform left ventricle pumping chamber. Blood is transcatheter aortic-valve implantation using evacuated and run through an LVAD that is the SAPIEN heart valve from Edwards Life external to the heart—and then the blood is Science. pushed back into the aorta. Five years ago, LVADs were considered Superior cardiovascular care that a short-term stop-gap for patients with weak drives innovation hearts who were awaiting transplantation. Transcatheter procedures that eliminate Now, due in large part to miniaturization the need for open-heart surgery represent and the research being done at UCH, a shifting approach to treating structural LVADs can be a longer-term solution for heart disease. Much of the technology and patients too old or weak to undergo heart innovation guiding this shift is being driven transplant procedures. by emphasis on superior cardiovascular care. Loyd Deavenport of Erie, Colorado, is One such innovation is new approaches one local resident who had his life extended to treating an irregular heartbeat. Today, it’s through the implantation of an LVAD. After possible to electronically map and ablate being told in 2009 that he only had a few disordered circuitry within the heart to cure hours to a few days to live because of his patients who have certain types of electrical weakened heart, Mr. Deavenport agreed to instability—the most common form being have an LVAD implanted.

BIOSCIENCE COLORADO 2012/2013 23 “It was very traumatic for me and my family to be told I might only have Highlighted Colorado Centers of Excellence hours to live,” says Loyd. “Following a brief period of indecision, I decided to go Meeting needs across a wide spectrum through with the procedure. After a few weeks I began feeling better. It did take Barbara Davis Center for Diabetes Linda Crnic Institute for Down some time to go through physical therapy University of Colorado, Anschutz Medical Syndrome and regain my strength and stamina, but Campus, Aurora University of Colorado, now I’m able to play golf a few times a One of the largest diabetes programs Anschutz Medical Campus, week, enjoy my family and even take a specializing in type 1 diabetes research and Aurora few well-deserved vacations.” care (both children and adults) in the world. The first global institute to www.barbaradaviscenter.org encompass basic research, Ultimately, the innovative clinical research, and clinical cardiovascular research and science being Children’s Hospital Colorado care specifically for people with done at UCH is about restoring quality Anschutz Medical Campus, Aurora Down syndrome. of life for people like Loyd Deavenport. Ranked for more than a decade as one of the www.CrnicInstitute.org Through close associations with academic best children’s hospitals nationally—home entrepreneurs and an emphasis on to a number of nationally and internationally Marion Downs Hearing Center advancing minimally invasive heart recognized medical programs. University of Colorado, procedures, UCH is poised to grow even www.childrenscolorado.org Anschutz Medical Campus, stronger as a regional center of excellence. Aurora Recently, UCH finalized a joint Craig Hospital Recognized worldwide for operating agreement with Poudre Denver unique leadership, stellar service World renowned as a premier center for provision and progressive inno- Valley Health System that creates a specialty rehabilitation and research for vations in the realm of hearing, health network industry leaders say will people with spinal cord injury and traumatic and deafness. expand healthcare services, and provide brain injury. www.mariondowns.com unmatched patient care in the Rocky www.craighospital.org Mountain region. And in the end, that’s what it’s really all about.

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24 2012/2013 BIOSCIENCE COLORADO Center of Biofuels Excellence Colorado At the Center of Biofuels Research

BY Andrea Pawliczek

iofuels, fuels derived from biomass efficient separation of isobutanol, a naturally such as wood or corn, lie at the occurring alcohol. intersection between the bioscience Another innovative company is OPX Band clean technology industries. Biotechnologies of Boulder, whose OPX Creating these fuels efficiently takes a deep EDGE™ (Efficiency Directed Genome understanding of biological and chemical Engineering) technology platform allows processes that can turn the original biomass, for the rapid optimization of the microbes algae for example, into a usable product used to create bio-products. This rapid such as biodiesel. The effort is well worth optimization process makes it possible it, however, since biofuels can be produced to produce a variety of products at a with less carbon emissions and particulate cost advantage over petroleum-based pollution than traditional fossil fuels. alternatives. It’s not surprising that Colorado’s Many experts expect a key driver in strengths in both bioscience and clean the adoption of biofuels will be cost- technology have made it a hub of activity comparability relative to petroleum-based for biofuels. Many of the state’s research a bio-based alternative to petroleum- alternatives. The innovations taking place institutions are pushing the envelope, their based products. Gevo uses a proprietary in both the research institutions and sights set on creating the world’s next fermentation method (Gevo’s Integrated companies within Colorado could well generation of biofuels. Much of this activity Fermentation Technology® or GIFT®) play important roles in making biofuels is based in Golden, Colorado, home to that relies on an innovative biocatalyst and commercially viable. both the Colorado School of Mines and the National Renewable Energy Laboratories. These institutions are both involved in the National Advanced Biofuels Consortium, a group focused on producing hydrocarbon fuels that are both sustainable and cost- effective, and which received $33 million in funding from the Department of Energy in 2010. At the School of Mines, for example, Professor Anthony Means is leading the school’s part of the project—working on a theoretical analysis of the chemical reactions that occur during the biomass conversion process as well as reactor design.

The goal: commercially viable biofuels production Along with these research institutions, several Colorado companies are looking for ways to commercialize innovative methods of biofuel production. Among them is Englewood-based Gevo, which is developing

BIOSCIENCE COLORADO 2012/2013 25 Center of Stem Cell Excellence

A Culture of Excellence and Firsts The Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology brings top scientists together to develop new therapies

BY Adam Rubenstein

ince its founding in 2006, the Charles C. Gates Center for Regenerative Medicine and Stem SCell Biology (Gates Center) at the University of Colorado has rapidly and efficiently established itself as a premiere national and international research and clinical center of excellence. Building on an original $6.5 million gift from the Gates Frontiers Fund, the Gates Center was able to expand its stem cell research program into pediatrics when an additional $5 million dollar gift was apportioned to the Fitzsimons-based Children’s Hospital in 2007. In just over five years, the Gates Center has already made significant contributions. Led by Founding Director Dennis Roop, PhD, the Center attracted top scientists in the field, built a world-class series of core laboratories dedicated to the study of stem cell biology and launched, with initial support from a donor the Cancer Stem Cell-Directed Clinical Trials Program (CCTP) which is a collaboration between the University of Colorado Cancer Gates Center scientist preparing to feed cultured stem cells Center and the Gates Center. The CCTP is directed by Dr. Antonio Jimeno and is leveraged into additional funds. In 2010, a donor that he had recently visited on a “First-in-Nation” program focused on I received a call from Wayne Hutchens, a trip to New York, where he informed identifying and testing drugs that target who at that time was CEO of the CU him about some of the exciting stem and destroy cancer stem cells. Foundation (He recently retired after cell research being carried out in the “The CCTP is a wonderful example serving as CEO for six years). Wayne had Gates Center. I used these funds, plus an of how a modest gift from a donor can be just received a check for $50,000, from additional $250,000 from Gates Center

26 2012/2013 BIOSCIENCE COLORADO The BioFrontiers funds, to help Dr. Jimeno establish the mechanisms that drive stem cells to CCTP in June, 2010. On the basis of grow and differentiate into a spectrum of Institute, University preclinical data obtained with these tissues, organs, bones, and blood. of Colorado funds, Dr. Jimeno has recently received a • Stem Cells and Disease – $650,000 grant from the NCI to support Understanding the foundation of stem a new clinical trial in head and neck cell biology to identify certain mistakes cancer, as well as, a gift of $300,000 that can occur as these unique cells from another donor,” said Dr. Roop. differentiate. Such errors may lead to a Housed in the state-of-the-art vast array of diseases, from birth defects Research Complex I on the Anschutz to cancers. Targeting where they occur The BioFrontiers Institute is uniquely Medical Campus (AMC), the newest and in the developmental process is the defined by its excellent researchers and largest biomedical and clinical campus second step to designing therapeutic and leadership, and by the scientific and in the United States, the Gates Center regenerative approaches. geographical ecosystem that empowers is open to all investigators interested • Stem Cells and Regenerative their work. in stem cell research within the greater Medicine – Building on a foundational The Institute is housed in the state- Rocky Mountain region, including understanding of stem cell biology and of-the-art Jennie Smoly Caruthers investigators at UC AMC, UC Denver, the identification of diseases linked to Biotechnology Building on CU-Boulder’s UC Boulder, National Jewish Health, and damaged or destroyed stem cells. Once East Campus. This new facility will Colorado State University. The goal of damaged or destroyed stem cells have bring together the scientific vision of its program is to understand the biology been identified, replacement cells are BioFrontiers and the resources it takes of stem cells in order to develop new engineered and induced to differentiate to explore critical areas of unknown therapies for debilitating diseases. into the very cells that have ceased their biology and translate that knowledge into Investigator research foci at the Gates correct function. applications that will advance human Center fall under four broad headings: • Stem Cells and Cancer – This area can health and welfare. • Stem Cell Biology – The study of be thought of as the opposite of stem biofrontiers.colorado.edu

Gates Center Core Research Facilities These facilities provide specialized services to the research community, enabling investigators to outsource experiments that require specialized knowledge and technical abilities not found in most laboratories.

• Flow Cytometry Core – provides a wide range of assays including cell cycle, proliferation, apoptosis, viability, signaling, detection, fluorescent protein analysis, phenotyping, and cell sorting, including stem cells.

• Morphology and Phenotyping (Histology) Core – provides all of the tools and expertise necessary to process and analyze tissue samples.

• iPSC Core – generates custom-designed iPSCs from mouse and human cells, including disease-specific human iPSCs. (iPSCs are adult cells that have been genetically reprogrammed to an embryonic stem cell–like state.) Pharmaceutical Research & Manufacturers of America Disease is our enemy. Working to save lives is our job. • Transgenic and Gene Targeting Core – provides engineered mouse models for gene targeting in embryonic stem cells, the generation of knockout and knock-in mice, and the cryo-preservation of mouse lines.

BIOSCIENCE COLORADO 2012/2013 27 cell regenerative medicine. When cancer that has already produced a number of Pharmaceuticals, developer of IPI-926. stem cells are present, their proliferation notable “firsts.” Gates researchers were Preclinical studies of this combination is uncontrollable. Therefore, the mission the first in the nation to conditionally therapy approach, led by University of is to destroy the cancer stem cell so that immortalize blood stem cells and expand Colorado researcher Antonio Jimeno, it is no longer able to regenerate, thereby them indefinitely. The first to differentiate MD, PhD, yielded striking results. ceasing and ultimately reversing the stems cells into astrocytes and enable Jimeno is now the trial’s principal growth of tumors. these to grow and repair spinal cord investigator, leading enrollment of 18 to injuries in rodents. And the first to 24 Coloradoan’s with relapsed head and The minds, resources develop a mouse-human chimera stem neck cancers. and culture cell model to help accelerate personalized “When I first came to Denver in What makes a scientific research medicine discovery 2007, I spent a lot of time meeting with organization a center of excellence? As mentioned above, perhaps the potential donors. Often, their comments Excellence requires expert human Center’s most notable accomplishment were something like “It will be 15 to capital—people who are internationally was being first in the nation to establish 20 years before what you are proposing known in their domains—plus the a human phase I clinical trial of will affect the lives of patients.” Now, to resources to enable those experts to the investigational drug IPI-926, in those critics I can say, “You were wrong, expand knowledge and understanding combination with the drug Cetuximab, within five years of establishing the Gates on daily basis. And, there is another for the treatment of recurrent head and Center, stem cell based research is already important factor—the presence of a neck cancer. This investigational therapy changing the way that Dr. Jimeno treats culture that expects breakthroughs that is uniquely designed to target traditional his cancer patients,” said Dr. Roop. links researchers together. tumor cells in concert with cancer stem Clearly, the pieces have been put in The Gates Center has all of those cells. The trial is a joint effort between place by the Gates Center for many more ingredients—the finest minds and the Gates Center, the University of firsts to come in the field of stem cell resources in stem cell biology and a culture Colorado Cancer Center, and Infinity biology and regenerative medicine.

Where bioscience means business Aurora is home to the Anschutz Medical Campus and Fitzsimons Life Science District, one of the largest bioscience redevelopment projects in the United States. The 578-acre site is undergoing a $5.2 billion transformation that will result in more than 18.5 million square-feet of space dedicated to excellence in health care, education and research.

Visit www.auroraedc.com for more information on Colorado incentives, our highly skilled workforce, and other resources that make Aurora the location for your next bioscience venture.

28 2012/2013 BIOSCIENCE COLORADO Excellence across the Centers Colorado Clinical & Translational Sciences Institute: Connecting Colorado Communities

This program, directed CCTSI patient care by Ronald J. Sokol, MD, distinguished professor of medicine, is housed at the University of Colorado Denver and relies upon the participation of numerous affiliate CCTSI members throughout the state of Ronald J. Sokol, Colorado (see box). MD, Director The Colorado CCTSI institute’s mission is focused on biomedical discovery and translating lab-based discoveries into new or improved applications of patient care and community health, as well as reducing health disparities among communities. The CCTSI is charged with the challenging task of coordinating the efforts of a large group of talented scientists, health care providers, and advocates across Colorado—including two research universities (University of Colorado Denver and Boulder), six health care professional schools, five hospitals (Denver Veterans Affairs Medical Center, National Jewish Health, Denver Health, Children’s Hospital Colorado and the University of Colorado Hospital), a health care network (Kaiser Permanente Colorado), and over a dozen community health programs. BY Adam Rubenstein Funded at $500 million annually, CTSA institutions work to transform local, Empowering a new generation regional, and national environments by of scientists increasing the efficiency and speed of An overarching objective of the clinical and translational research. Institute is to enhance, integrate, and he Clinical and Translational Nationwide, 60 medical research transform the training methods of Science Awards (CTSA) program institutions in 30 states are active new investigators. By pursing a novel at the National Institutes of members of the CTSA Consortium. approach to scientific translational T Health coordinates clinical In 2008, the CTSA supported the thinking, the CCTSI hopes to empower and translational science centers at founding of the Colorado Clinical & a new generation of scientists with institutions across the United States. Translational Sciences Institute (CCTSI). interdisciplinary and collaborative

BIOSCIENCE COLORADO 2012/2013 29 CCTSI Statewide CollabFlu. A clinical trial in action Participating Partners Sponsored by the University of Colorado and the Center for Disease Control & Prevention • American Academy of Family Physicians National Research Network Beginning with the 2009-2010 season, influenza vaccine has been universally recom- • American Indian/Alaska Native (AI/AN) mended for children age six months to 18 years old, placing extra burden on health care Programs providers across the U.S. The focus of this study is to develop new strategies and imple- • Building Investigative Practices for Better ment existing evidence-based strategies to enhance influenza immunization in these Health Outcomes children. The intervention will involve collaboration from different types of primary care • Catholic Health providers, the Colorado Immunization Information System, public health departments, and • Children’s Hospital Colorado visiting nursing services. Primary outcome measures in the intervention and control groups • Colorado Cardiovascular Outcomes include: Research • Colorado Children’s Healthcare Access 1) increase in the rate of receipt of ≥1 influenza vaccines during the post-intervention year Program compared to the pre-intervention year among children 6 mo.-18 yr. • Colorado Foundation for Public Health 2) increase in the rate of children 6 mo.-18 yr. who were fully immunized (received all and Environment required influenza injections) during the season • Colorado Pharmacy Practice Education & 3) measure outcomes by age group (6 mo.-5 yr., 6-8 yr., 9-12 yr., 13-18 yr.) and types of Research Network clinical sites (urban pediatrics, urban family medicine, rural family medicine) • Colorado Research Network • Denver Health • Denver Metro Emergency Network • Denver Veterans Affairs Medical Center Colorado is host From bench to bedside: • Kaiser Permanente Colorado to thousands of translational • LUCHAR-Latinos Using Cardio Health Actions to Reduce Risk local, national, research and • National Jewish Health and international medicine • National Surgical Quality Improvement trials. Recruiting Program and ongoing trials Translational research is the • Nurse Family Partnership currently include: process of applying discoveries in • Population-based Palliative Care Research the laboratory, and in preclinical Network Focus No. of Trials studies, to the development of • Rocky Mountain Altitude Network Asthma 17 trials and studies in humans. It • Stapleton 2040 Cancer 174 also includes research aimed at • University of Colorado, Denver and Diabetes 38 enhancing the adoption of best Boulder Heart Disease & Stroke 23 practices in the community. • University of Colorado Health System Mental Illness 30

skills that foster a team approach to Sharing discoveries, seeking input Integration of community, be it investigation. The Institute places particular the academic, the clinical, or the four Its success is measured in several ways: emphasis on connecting disparate million residents of Colorado, is of • Accelerating the translation of communities through the dynamic paramount importance to the CCTSI. The laboratory discoveries to clinical use, Partnership of Academicians and Institute’s unique approach to fostering and bringing these clinical advances into Communities for Translation—a collaboration is apparent in the thoughtful communities partnership that facilitates exchanges design of its key programs: • Applying new technologies to the between communities and academic • Biostats, Epidemiology and Research delivery of personalized medicine programs. This communication channel Design – Analytical services required by • Delivering next generation training to allows scientists to share discoveries with clinical trials, training and mentorship for future researchers communities while asking communities in students and investigators • Advancing child and maternal health turn to inform scientists what medical and • Translational Informatics – Tools to public health needs should be addressed. help researchers find data, storage and

30 2012/2013 BIOSCIENCE COLORADO analysis of data • Novel Clinical and Translational Methods Development and Translational Technologies– Identification of clinical and translational research questions that require development of a novel methodology, analysis and application of The Colorado Small Business Development resources Center Network is dedicated to helping small • Evaluation and Tracking – Quality businesses throughout Colorado achieve their control and assurance to keep the goals by providing free confidential consulting Institute focused on its missions and various training programs. • Clinical and Translation Research www.ColoradoSBDC.org Centers– Centrally administered and coordinated infrastructure of participating hospitals and campuses • Building Human Capacity for Clinical and Translational Research – Educational and skills training to promote cross- collaborations, and enhance Colorado’s workforce and national leadership in clinical-translational research • Community Engagement – Integration of existing community and academic partnerships into a collaborative, broad- based enterprise that enhances public trust and reduces health disparities Intellectual Asset Management magazine • Child and Maternal Health Research ranked Sheridan Ross second in the U.S. – Clinical and translational research in in securing the highest-quality patents in the healthcare sector. children of all ages, pregnant woman, and... and the mother-child dyad to improve The National Institutes of Health selected child health and prevent diseases Sheridan Ross as one of only six patent rms • Regulatory Support and Knowledge – to protect its biotechnology inventions. Member support to navigate regulatory requirements and training in the responsible conduct of research You can’t argue with that. • Pilot and Collaborative Translational and Clinical Studies Program – One- Protecting ideas in the bioscience industry for more than 25 years year pilot grants to encourage cross- disciplinary and collaborative research in clinical and translational science “The CCTSI, through its broad base of over 2,500 interdisciplinary scientists, technologies and communities working together, is transforming the process of Impactful Editorial Media Placements translating new discoveries into better patient care and community health for the state of Colorado,” says Ronald J. Sokol, MD, CCTSI director. Together, Colorado and the Colorado Clinical & Translational Sciences Institute are pushing the envelope of translational medicine, leveraging its Maggie Chamberlin Holben, APR capabilities and communities to become www.Twitter/DenverPR an engine of innovation benefiting not only our state, but also our nation and Local • Trade • National • Social Media Strategies our world. [email protected] 303.984.9801

BIOSCIENCE COLORADO 2012/2013 31 32 2012/2013 BIOSCIENCE COLORADO

Center of Cardiac Excellence Medical Center of the Rockies Committed to exceptional achievement in cardiovascular care

BY Casey Demchak emphasis on creating highly efficient systems that result in better quality of care. ased in northern Colorado, the Poudre “During MCR’s inception, we decided we Valley Health System is a regional wanted to be heavily involved in scientific network of hospitals and clinics that research and groundbreaking cardiovascular Bprovide evidence-based health care clinical trials,” says Dr. Gary Luckasen, and wellness services to people in Colorado, who has been a driving force in MCR’s Nebraska, and Wyoming. An important heart program since day one. “By being so component in this network is Medical Center involved in innovative cardiovascular trials, of the Rockies (MCR), a 136-bed regional our Front Range community has access to center in Loveland, Colorado. conducts some clinical trials, this health world-class care without having to leave the MCR offers some of the region’s most system research facility is dedicated to region. And, we provide a platform from advanced cardiac care, including a highly being a nationally recognized cardiovascular which local companies can do research that innovative robotic-assisted surgery program. clinical trial site. Since being founded in becomes the foundation of important new As opposed to being a standard hospital that 2007, MCR has continually placed great technologies.”

cardiovascular trauma neurology infectious disease

www.mcrresearch.org

Dr. Gary J. Luckasen, Medical Director of Research, Medical Center of the Rockies Foundation

34 2012/2013 BIOSCIENCE COLORADO From northern Colorado to the world protein modulator. Dalcetrapib is intended BioScience Association enables MCR Thirty clinical trials are currently being to raise HDL, or “good cholesterol.” to build partnerships with numerous conducted at the Medical Center of the Currently, there are no other drugs proven organizations—all in an effort to help Rockies. Two of them are very noteworthy to achieve this outcome, so positive Colorado companies develop products that given the positive impact they could have on findings in this study could significantly will help the state stay at the forefront of cardiovascular care for people throughout improve heart disease treatment. medical technology innovation. the world. One Colorado resident participating in the MCR also maintains strong connections One is a prospective, multicenter, single- second study is Deb Lucero. After suffering with Colorado State University. This alliance blind, randomized controlled trial comparing the shock of a heart attack, Deb greatly has become fertile ground for several the Moxy drug-coated PTA catheter against appreciates the opportunity to be involved in potential innovations. The medical center is standard balloon angioplasty for the treatment the Dal-OUTCOMES trial. assisting the university with basic science on of femoropopliteal arteries in the leg. This “There is a definite health benefit to several projects that it hopes will lead to even is the first use of drug-coated balloons in a me being in the study because I receive more participation in successful animal and large trial population. A positive outcome extra checkups with my cardiologist that human studies. in this study could lead to advancements in I otherwise would not have,” reports Deb. As a leading science and research cardiovascular care that would decrease the “Plus, research is an important part of institution, the Medical Center of the need to use stents in heart arteries. developing new drugs. So I feel that not Rockies has proven to be a true partner for A second important study is the only could I benefit, but I could also be the Colorado bioscience industry. A close Dal-OUTCOMES trial, a long-term, helping other people with heart disease allegiance with the local community, along multicenter, international cardiovascular as well.” with the goal of being a nationally renowned outcome study. It is evaluating the efficacy In addition to maintaining long-term clinical trial center, are just two reasons why of a drug from Roche called Dalcetrapib, relationships with clinical trial patients, this medical center is widely recognized as a which is an oral cholesterol ester transfer a close connection with the Colorado Colorado center of excellence.

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BIOSCIENCE COLORADO 2012/2013 35 Bioscience Discovery Evaluation Grant Program

he Bioscience Discovery Evaluation Grant Program (BDEGP) was created in 2006 by the Colorado General Assembly to grow the bioscience industry in the state. The BDEGP provides gap funding to advance T promising research from Colorado’s outstanding research institutions into the marketplace. The bioscience industry in Colorado is strengthened by such efforts, resulting in long-term job creation and company formation. The BDEGP has been praised for its effectiveness in leveraging a limited state investment to move promising commercial technologies to market and supporting the biotechnology industry in Colorado. Since the first grants were made in mid-to-late 2007 through calendar year 2011 the program has awarded 130 grants to researchers at Colorado research institutions to bring their cutting-edge technologies closer to market. Forty-four grants have helped companies further these technologies as they complete studies, secure intellectual property, and develop their approach to bring their products to market. In addition, the program has supported four new bioscience technology organizations, under the commercialization infrastructure program, that identify and manage technologies, and support collaboration to bring necessary expertise together to advance novel Colorado biotechnologies to commercialization. The State leverages this investment in the industry by requiring a one-to- one match for both Proof of Concept and Early-Stage Company grants. The economic benefit is realized near-term in the strengthening of our research institutions, the jobs required to fulfill the grant work, and the products and services purchased to complete grant work. Longer-run payouts come in the form of additional capital investment into the technologies and companies, the creation of new companies, and growing businesses adding high quality jobs. Approximately $22.1 million from the BDEGP Cash Fund has been granted and will garner at least an equal amount in matching funds (excluding Commercialization Infrastructure grants). Of 184 grants made or approved under the program by the end of 2011, 96 have completed work while the others are in process. To date, the program successes include the creation of 34 new Colorado companies and the direct creation of 302 jobs. Additionally, these funds have helped the technologies acquire an additional $95 million in grants and investments to further commercialize these bioscience technologies.

36 2012/2013 BIOSCIENCE COLORADO PROOF-OF-CONCEPT Investigator: Hongjun Liang, Ph.D.

GRANTS 2011 -2012 Title: Development of Retrievable and Reusable Coagulation Agents for Highly Efficient Microalgae Harvesting and Cost- Effective Biofuel Production

Research: The specific objective of this proposal is to identify the rational correlations between inter-algal pair interactions and coagulation-agents with well-defined structures, and to develop a family of super coagulation agents for highly efficient microalgae dewatering at a negligible cost. It aims to clear the bottleneck limiting commercialization of microalgae-derived biofuels, and to foster successful growth of this industry by collaborative partnerships with algaculture companies. The central hypothesis is that nanoparticle-pinched polymer brushes are far more effective in dewatering microalgae than conventional flocculants; and COLORADO SCHOOL OF MINES solid-state nanoparticles allow low-cost operations to be designed to collect algal biomass and retrieve the coagulation agents for Investigator: Reed Ayers, Ph.D. multiple cycles of microalgae dewatering.

Title: Tri-Calcium Phosphate Manufacturing for Biomedical Ap- Impact: It is anticipated that the proposed work will yield the fol- plications lowing expected outcomes to transform microalgae dewatering: 1) low operational cost (the re-usable coagulation agents will mini- Research: Multiphasic calcium Phosphate (MCaP) materials ob- mize materials cost while the dewatering process will require low tained through the solid-state reaction of combustion synthesis can maintenance, consume little energy, and is continuously operable); be specifically formulated to mimic critical inorganic features of 2) high efficiency (the de-watering process is quick and has an ef- the bone, and may provide a novel method to enhance bone tissue ficiency of almost 100% compared to currently known coagulation healing. The success of the commercialization of this technology methods that typically harvest microalgae at efficiencies ranging depends mainly on demonstrating successful manufacturing scale- from 20-90%); 3) facile scale-up potential (the coagulation agents up to hundreds of grams of the material while preserving critical will impose no contamination to the growth medium for continu- mechanical and chemicals characteristics. Combustion synthesis ous, post-dewatering microalgae farming, and no interference to technique has a high commercial potential as it can be applied to downstream processes for biofuel conversion). other materials, allowing expansion to other markets including non-medical. The researcher is pursuing McaP as the material of choice as it is the fastest material to bring to market because it Investigator: Matt Liberatore, Ph.D. does not require FDA approval. Title: Dewatering Algae Cells Using Polymers to Scale Up Bio- Impact: Biomaterials products had a market size of $25.5 billion fuel Production in 2008, and the biomaterial device market size was $115.4 billion in the same year, and is expected to reach $252.7 billion in 2014. Research: The goal of the project is to identify polymers and de- Bone allograft is a sub-segment of the Orthobiologic biomateri- livery mechanisms to induce flocculation of algae in an optimized als market ($2.9 billion with the 7% growth rate). In 2009, its and cost efficient manner. A flocculation mechanism using poly- market size was about $0.75 billion. Future growth in the market electrolytes has developed intellectual property. The flocculating is expected to depend on fabrication technology improvements polymer may have a secondary benefit that the cells are more eas- and development of new products at competitive prices. Improved ily lysed to remove intercellular products (e.g., lipids). The project patient benefits form the most important factor stimulating market will focus on the optimization of flocculation with polymers and growth for biomaterials. The other market drivers are increase in complex, analytical measurements of the flocculation. The use of aging population, rising awareness, shorter product approval time, rheology in combination with light scattering will help identify and larger application area. However, the lack of tissue availability polymer chemistries and concentration regimes that result in floc- and proper reimbursement facilities are restraining the growth culation of algae cells at a minimal cost. of the biomaterials market. MCaP is intended primarily for the biomedical use with the focus on drug development and implant Impact: The technology allows for the scale-up for biofuel produc- device manufacturing. The goal is to provide high quality medical tion from algae. This technology could also be expanded to solids grade MCaP to the customers and to become a primary supplier separation and processing, a significant component of wastewater for MCaP for biomedical applications. treatment.

BIOSCIENCE COLORADO 2012/2013 37 Investigator: Keith Neeves, Ph.D. Investigator: Kent Voorhees, Ph.D.

Title: Microfluidic flow assays for evaluating anticoagulant and Title: Rapid Detection of Listeria Using Bacteriophage Amplifica- antiplatelet drugs tion and Enhanced Lateral Flow Immunoassays

Research: Part of the long-term goal of this research is to develop Research: The project looks to develop a handheld bacterial technology for evaluating, monitoring, and dosing therapeutics for detection device, which takes advantage of species-specific phage the treatment of bleeding and thrombotic disorders. Stepes have amplification (PA) and surface enhanced Raman spectroscopy been taken towards that goal with an in vitro vascular injury model (SERS) to maximize sensitivity and allow for a quantifiable called the microfluidic flow assay (MFA). The MFA consists of a readout while employing inexpensive lateral flow immuonoassay series of microfluidic channels with characteristic sizes of ~100 μm, (LFI) sample concentration for rapid, onsite screening of ready- which run perpendicular to micropatterned prothrombotic molecules to-eat foods and processing equipment for L. monocytogenes. The that trigger clotting, such as collagen and tissue factor. This technol- primary goals of the proposed research are 1) to characterize, and ogy captures the dynamics of clot formation under flow, which is utilize the L. monocytogenes-specific phage A511 and antibodies currently absent in conventional clotting assays. Within a single produced against that phage to develop a cost-effective, rapid, and assay we can flow blood over the range of physiologic shear stresses accurate diagnostic detection device and 2) to demonstrate the in different channels and monitor the growth and stability of the utility of that detection device for rapid, user-friendly screening each clot in real-time with various microscopy methods. To date, we of ready-to-eat meats and cheeses, produce, and food processing have shown that the MFA can be used as a diagnostic tool to detect equipment with an expected total sampling and analysis time in dysfunctions on platelet function and coagulation. The objective of the 5 to 7 hour timeframe. this study is to extend the application of the MFA towards the evaluation of new anticoagulation and antiplatelet agents. Impact: Rapid diagnostic detection of food-borne Listeria at the farm and/or processing level is vital for the prevention of Listeria- Impact: The market for the technology developed in this project related illness and mortality. Conventional testing has historically will target the cardiovascular disease diagnostic market, specifically relied upon the use of inefficient off-site government or corporate point-of-care (POC) diagnostics. From 2003 to 2008 there was an analysis laboratories using expensive, time-intensive methods 8% increase (CAGR) in U.S. POC market from $1.68 billion to that have made high-volume testing impractical. As a result, the $2.28 billion. Coagulation and cardiac markers represent approxi- demand for a shift to more feasible onsite testing using much mately 15% of this market, and over the same period had double- cheaper detection methods has risen sharply. Several attempts have digit growth (13% CAGR). The coagulation monitoring market was been made to meet this demand. However, even the most rapid of estimated at $445 million in 2006. There are several drivers that currently available products requires a minimum of 24 hours at a suggest further market growth in POC, including a government fo- significant cost. The next best option requires a minimum of 48 cus on reducing hospital length of stay, economic focus on enabling hours also at a significant cost. While considered the current state more effective and efficient care, advances in lab-on-chip technol- of the art, these products still fall short of tractable, inexpensive ogy, and an increased use of information technology to deliver and on-site testing capabilities. In contrast, the proposed PA, SERS- manage diagnostic results. Furthermore, the development of new based LFI device will make Listeria testing possible in as little as anticoagulant and antiplatelet drugs is expected to increase the need 5 to 7 hours at an estimated cost of $50 per kit, requiring the use for affordable and accurate predictors of therapeutic efficiency. The of a $3,500 Raman spectrometer, far below the costs for the other explosion of a new class of oral anticoagulants that target factor Xa current tests. and thrombin is expected widen the use of anticoagulants, which will require concomitant measures of their efficacy.

38 2012/2013 BIOSCIENCE COLORADO COLORADO STATE UNIVERSITY

Investigator: Anne Avery, Ph.D. Investigator: John D. Fisk, Ph.D.

Title: Development of a Diagnostic Assay for Canine Hemangio- Title: Biosensor Platform Development via Protein Assembly sarcoma Engineering and Device Integration

Research: The goal of this project is to create a blood-based Research: The goal of this project is to develop sensors for the diagnostic test for a common canine tumor that is otherwise detection of active tuberculosis infections using phage-based expensive to diagnose. The project is also intended to demonstrate biological reagents in paper microfluidic devices. To achieve this the feasibility of this approach for developing a broad array of goal, effort will be focused on developing and establishing the non-invasive cancer diagnostics in human and veterinary patients. properties of phage-based sensor components in different physical sensor platforms. Impact: Cancer diagnosis can be invasive and expensive, often, for visceral organs, including biopsy and anesthesia. Less invasive Impact: Approximately 1/3 of the world’s population is infected blood tests reduce costs and morbidity associated with obtaining a with tuberculosis, and 15 million people develop active disease diagnosis. Blood-based diagnostics for tumors of canine patients annually—the majority in the developing world. The existing para- will have particular utility, since the prohibitive cost and invasive- digm for the detection of tuberculosis relies on tests that are slow, ness of the procedures often preclude their usage. Successful expensive, and require laboratory resources not typically found implementation of blood-based tests will save money, discomfort, in resource-poor areas. As a result, faster, cheaper, point-of-care and, potentially, lead to better patient outcomes. diagnostics of active tuberculosis infections are needed.

Investigator: Fausto Bellezzo, DVM, DACVS and Dean Hen- Investigator: David A. Prawel, Ph.D. and Susan P. James, Ph.D. drickson, DVM, MS, DACVS Title: Enhanced Osseointegration of PEEK Implants Title: High Fidelity Abdominal Surgical Simulator Research: The goal of this project is to validate a novel approach Research: The goal of this project is to create an abdominal cav- for enhanced osseointegration of poly ether ketone (PEEK) fusion ity model that represents with accuracy the anatomical details of devices. surgical relevance for use as a medical education tool. Vascular and organ structures will be included, which mimic the shape, tex- Impact: The proposed research would significantly enhance surgi- ture, color, and location of real structures, as well as blood color, cal outcomes for patients who undergo spinal fusion for conditions viscosity, flow, mechanics, and pressure. such as tumor, spinal fracture, degenerative disc disease, scoliosis, and other deformities--an estimated 330,000 people annually in Impact: Existing surgical training tools for medical and veterinary the US alone. students are limited to rudimentary models, including orange peels, carpet pads, or live animals, which are not anatomically correct with respect to the human body, while still being very Investigator: Melissa M. Reynolds, Ph.D. expensive. Other simulators use video based training, but lack the hands on approach of this new model. This new technology will Title: Quantitative Assessment of Bio-Bandaids - Innovative Mate- address an unmet need in medical schools, hospitals, and simula- rials to Treat Wounds tion centers, as well as in military medical training. Research: The goal of this project is to evaluate a class of new biodegradable polymers - bio-bandaids - for their ability to treat infection and promote wound healing. A data set will be collected to support the application of these new materials to overcome the lingering problems associated with wound healing.

Impact: Currently, there are no treatments that can address all of the problems caused by traumatic injury, such as bleeding, infection, and soreness, and some treatment options can cause significant side effects to put patients at more risk. Bio-bandaids are expected to address these issues, providing a superior treatment option to those currently available.

BIOSCIENCE COLORADO 2012/2013 39 Investigator: Larry Roesner, Ph.D., P.E. Investigator: Richard A. Slayden, Ph.D.

Title: Determine the Biological Efficacy of Graywater Reuse Title: Identification of Potentiating Agents that Enhance Treat- ments Caused by Pseudomonas Aeruginosa Research: The objective of this project is to demonstrate that a simple, low energy input, graywater resuse system comprising Research: The goal of this project is to identify lead compounds storage with disinfection will produce a water supply for toilet that impact drug resistance in Pseudomonas aeruginosa via drug flushing that poses no public health risk. efflux. It is hypothesized that, when co-administered with existing clinically used drugs, these compounds could potentiate drug Impact: Utilizing graywater in toilet flushing will reduce the de- activity. The identified compounds can then be used in preclini- mand for fresh water resources and reduce wastewater flows. This cal studies to assess utility in the treatment of disease caused by wastewater resuse system will serve as an alternative to current Pseudomonas aeruginosa. systems, which are large, costly, and require large energy inputs. Since wastewater treatment currently accounts for 36% of the City Impact: Pseudomonas aeruginosa is a pathogen of increasing med- of Fort Collins energy expenditure, the gains from adopting such a ical importance, because it is nosocomial and causes significant in- system locally would be substantial. fections in immunocompromised individuals, including the elderly and chronically ill. Since Pseudomonas aeruginosa is naturally resistant to a wide range of chemotherapeutics, these infections Investigator: Herbert Schweizer, Ph.D. can be difficult to treat and manage. Reducing the pathogen’s resistance, thereby potentiating existing drugs’ efficacy will improve Title: Production of Genetically Engineered Materials management and treatment options for patients.

Research: The goal of this project is to facilitate the distribution of genetically engineered materials, such as broad-host-range Investigator: Ronald B. Tjalkens, Ph.D. plasmids and bacteria, to the scientific community and to facilitate their continued development. This includes producing stocks of Title: Development of Neuroprotective Compounds for Treating commonly requested materials, developing an electronic database Parkinson’s disease, Phase 2: Safety Evaluation to track distribution, and evaluating the use of the non-antibiotic glyphosate resistance marker in drug resistant bacteria such as Research: The goal of this project is to develop a novel anti- Acinetobacter baumannii. inflammatory, neuroprotective drug to block the progression of Parkinson’s disease. The project supports the evaluation of a novel Impact: There is a significant unmet medical need to introduce class of synthetic triterpenoid structures that have discreet modifi- new antibacterial agents to combat resistance to current drugs. cations to optimize anti-inflammatory activity in neural cells. Genetically engineered strains of bacteria are a very important and highly used tool in the discovery process; however many of Impact: Parkinson’s disease is the second most common neuro- these tools have not previously been commercially available. This degenerative disease in the United States, effecting more than project will help to facilitate these discovery efforts, potentially 1.5 million people. Current drugs for Parkinson’s treat only the speeding the commercialization of new antibacterial agents. symptoms of the disease, without addressing the condition, itself, or curtailing its progression. Thus, a drug that blocks the progression of Parkinson’s would extend and improve the quality of life for those suffering from the disease.

40 2012/2013 BIOSCIENCE COLORADO NATIONAL JEWISH HEALTH

Investigator: John C. Cambier, Ph.D.

Title: Advancing Human CD79-targeted Therapy Using huMouse Models

Research: Using mouse models it was discovered that anti-CD79 antibodies are therapeutic in Lupus-like disease and Type 1 Diabe- tes, and prevent development of Collagen-Induced Arthritis (CIA). Importantly, these antibodies act by a mechanism involving receptor desensitization which is distinct and advantageous over current B cell-targeted drugs, Rituxan® and Benlysta® (which act by B cell depletion). Since anti-mouse CD79 mAbs do not cross-react with human CD79, further development of this technology required the researchers to produce and test a panel of mAbs specific for human CD79. To improve the marketability of this technology and lead mAbs the researchers will demonstrate their therapeutic activity in preclinical models. Mice that express human CD79 will be developed and will enable in vivo studies of the efficacy of anti Investigator: Mari Numata-Nakamura, M.D., Ph.D. and Dennis human CD79antibodies. R. Voelker, Ph.D.

Impact: Mice expressing human CD79 will enable researchers to Title: Novel Antiviral Lipids for Extended Prophylaxis and Post- establish the efficacy of antibodies against human CD79. These an- Infection Treatment of Respiratory Syncytial Virus Infections tibodies have the potential to become new drugs in the treatment of autoimmune diseases like lupus, rheumatoid arthritis, and diabetes. Research: Respiratory syncytial virus (RSV) is the most common cause of hospitalization for respiratory illness in young children - 90% of children under age 2 are infected by this virus annu- Investigator: Claudia Jakubzick, Ph.D. ally. RSV is also currently recognized as an important pathogen in adults, particularly in the elderly, patients with chronic lung Title: Apoptotic Cell-like Liposome Nanoparticles for Cell Medi- disease, and those with impaired immunity. Despite decades of ated Immunity research, no vaccine is clinically approved, or effective for preventing RSV. Researchers have demonstrated that one of the minor Research: Cancer is one of the most enduring health problems components of pulmonary surfactant, palmitoyloleoyl- phos- of the modern era. Recent developments using immunological phatidylglycerol (POPG) markedly attenuates proinflammatory techniques offer substantial new promise for developing vac- cytokine production (IL-6, IL-8) induced by RSV, and prevents cines against immunogenic cancers. Researchers are develop- viral replication in human bronchial epithelium. POPG also sig- ing a method for educating the endogenous immune system to nificantly attenuates RSV infection in vivo, in mice, by a factor of recognize and target tumor cells. The approach capitalizes on the 2,000 when the lipid is administered at the same time as the virus. specialized functions of certain dendritic cells (DCs) to recognize Data also show that POPG can be applied as an inhibitor of infec- antigens within apoptotic cells and induce differentiation of naïve tion in a short time window of approximately 45 minutes, prior to T cells into cytotoxic T cells to eliminate tumor cells. While this viral challenge. The aims of this project are direct extensions of approach is highly promising, it is believed that the development the recent findings and are focused on another minor pulmonary of DC-based cancer vaccines will be substantially enhanced by surfactant lipid, phosphatidylinositol (PI). These aims are designed exploiting the different functional roles played by specific DC to elucidate: 1) the pre-infection efficacy of extended PI treatment subtypes present in tissues. This proposal focuses on the lung, and as an anti-RSV agent, 2) the post-infection efficacy of PI treatment outlines experiments designed to take several critical steps towards of RSV infection and 3) the in vivo action of POPG applied after developing a viable vaccine treatment for immunogenic cancers in an RSV infection is established. humans. Impact: Successful accomplishment of these aims will provide Impact: This cancer vaccine constitutes a paradigm shift in cancer critical new information about the effectiveness and applicability immunotherapy. The designed vaccine is non-species specific and of PI and POPG as novel preventatives and therapeutics for RSV if successfully developed, the vaccine designed in this proposal infection, and treatment for drug-resistant RSV. This proposal will could provide long-lasting or permanent remission of a cancer also provide essential insights into development of new POPG without requiring radiation, chemotherapy, or other treatments and PI-like drugs as anti-viral agents for therapeutic application in with adverse long-term effects. humans.

BIOSCIENCE COLORADO 2012/2013 41 Investigator: Preveen Ramamoorthy, Ph.D. and Paul Reynolds, Ph.D.

Title: Development and Validation of an Integrated Clinical Diag- nostic Test Panel for Primary ImmunoDeficiency Disease (PIDD)

Research: Blood tests are the most widely used method for diagnos- ing PIDD. Through blood tests, physicians obtain the total number and type of white blood cells, and the quantity of vital immunological proteins such as cytokines and complement proteins that are produced by the body in response to an infection. Physicians also use other tests to measure the functionality of white blood cells and complement proteins. Although these methods are well validated, they are unable to pinpoint the specific defects in the immune system that are responsible for PIDD. They also cannot identify the underlying genetic cause of PIDD. As a result, patients often receive a correct diagnosis only after accumulating serious infections, diminishing the utility of potentially life-saving therapies such as bone marrow transplantation. The researchers have identified four unmet needs in PIDD diagnosis: (1) Investigator: Robert L. Garcea, M.D. a clinical diagnostic algorithm for PIDD diagnosis using integrated diagnostics (immunology, complement and genetic testing), (2) a Title: Development of a Next Generation, Multivalent Human comprehensive genetic test panel for PIDD diagnosis, (3) clinical Papillomavirus Vaccine decision support to help physicians order PIDD clinical diagnostic tests, interpret the results of these tests and guide treatment and Research: The goal of the project is to develop a multivalent HPV clinical management of patients, and (4) physician education. This vaccine by combining recombinant viral apsid subunits (capso- project is meant to address these four unmet needs. meres) from relevant HPV types. These subunits will be purified Project work aims to develop and validate a comprehensive after expression in bacteria using a new technology. In parallel, genetic test panel for PIDD composed of 225 genes. This test will monoclonal antibodies to each HPV type will be characterized be offered with established immunological and complement tests for use as in-process quality control reagents for future vaccine in conjunction with clinical decision support thereby creating an manufacture. integrated clinical diagnostic test panel for PIDD. Impact: Infection with high-risk types of human papillomavirus Impact: This project has the potential to lead to the development of a di- (HPV) is the initial event in the development of cervical cancer. agnostic test for PIDD. This test would enable doctors worldwide to di- Worldwide, approximately 300,000 women die annually from agnose patients with PIDD earlier, with greater efficiency and accuracy. this disease the majority of these deaths occur in under resourced regions of the world that have inadequate medical care. This proposal aims to develop a low cost HPV vaccine that can be UNIVERSITY OF COLORADO BOULDER deployed in these less-developed areas. BIOFRONTIERS INSTITUTE

Investigator: Christopher N. Bowman, Ph.D. Investigator: Leslie Leinwand, Ph.D.

Title: Thio-Ether Nucleic Acids: Next-Generation Genomic Re- Title: Novel Approach to Reversal of Heart Failure search and Therapy Tools Research: The strategic objective of this pre-clinical project is Research: The scope of this project is to develop and implement a to develop modulation of AQP7 expression and/or activity as a new class of oligonucleotide molecules that would have significant therapeutic tool to promote beneficial cardiac adaptation in the advantages over both biological (DNA and RNA) and synthetic presence of pathological stimuli. The key scientific objective is to (PNA) oligonucleotides for directing nanoassembly, biodetection, define the cardioprotective role of AQP7 via its ability to regulate and biofunctional applications including implementation in a mammalian heart cell size, function, and gene expression. SELEX-like process for TNA molecules, TNA-FISH, and TNA- based microarray format chips. Impact: Currently available therapies for the treatment of heart failure are largely palliative and there are no drugs capable of pro- Impact: The overall concept is that the synergistic combination of moting beneficial patterns of cardiac growth and gene expression thiol-ene-based click chemistry with oligonucleotide synthesis has in the face of pathological stimuli. Given this large unmet need, enabled the formation of an entirely new, highly functional, trans- novel strategies for promoting beneficial cardiac adaptation in formative oligonucleotide material that will be developed here for the face of pathological stimuli will have significant commercial several specific biological applications. potential.

42 2012/2013 BIOSCIENCE COLORADO Investigator: Malik Kahook, M.D.

Title: A Non-Invasive Surgical Device for Treatment of Glaucoma

Research: The goal of this project is to compare a non-invasive glaucoma treatment device to the efficacy of laser trabeculoplasty (standard of care) in a cohort of patients with open angle glaucoma. This non-invasive treatment beneficially alters the protein expression in the drainage system of the eye through stretching of the trabecular meshwork cells.

Impact: Glaucoma is a leading cause of world-wide blindness. Increase intraocular pressure (IOP) has been identified in multiple studies as a leading cause of glaucomatous optic neuropathy. It is Investigator: Hang (Hubert) Yin, Ph.D. believed that the cause of IOP elevation in glaucoma patients is due to dysfunction of the drainage angle of the eyes. The cells that Title: Minimally Invasive Diagnosis of Metastatic Cancers in make up the drainage angle are known as trabecular meshwork Body Fluids (TM) cells and their function is regulated by regional proteins, which can lead to both increased or decreased outflow of fluid out Research: The goal of this project is to create an in vitro cancer of the anterior chamber. The subject is designed to non-invasively metastasis detection system using unnatural cyclopeptides that alter the protein expression in the drainage system of the eye select for shed lipid vesicles and reveal the occurrence of cancer through stretching of the TM cells. metastasis.

Impact: The ability to detect exosomes of tumor origin from a Investigator: Uday B. Kompella, Ph.D. blood draw or a urine sample without the need for a biopsy or surgically resected tissue has a number of advantages. Frequently, Title: Novel Protein Drug for Wet Age Related Macular Degenera- fresh tissue is difficult or impossible to access, and archival tissue tion (AMD) samples are often less relevant to the current state of the patient’s disease. The ability to monitor biomarkers in real-time presents Research: A new therapeutic fusion protein (transferrin-tumstatin several opportunities including continuous monitoring of disease or Tf-T) that acts through mechanisms other than vascular endo- progression and recurrence, and monitoring the development of thelial growth factor (VEGF) inhibition has been developed. The patient resistance over the course of therapy. Our cyclopeptide- fusion protein has the ability to localize to the affected choroid based detection technology provides an attractive alternative as tissue and selectively inhibit the growth of new blood vessels. The minimally invasive probes for the screening of cell-derived exo- goal of this project is to perform non-GLP efficacy and safety somes as a general indication of cancer metastasis. studies of endotoxin free transferrin-tumstatin (Tf-T) in preclinical models.

UNIVERSITY OF COLORADO DENVER Impact: Tf-T is expected to improve patient outcomes either alone or in conjunction with anti-VEGF agents. AMD is the most common cause of irreversible vision loss in elderly patients. Investigator: Richard J. Johnson, M.D.

Title: A Novel Treatment to Prevent Acute Kidney Injury from RadioContrast

Research: The goal of this project is to develop a therapeutic for acute kidney injury (AKI) to target the underlying mechanism for contrast-induced nephropathy. The University has intellectual property around a target and candidate therapeutic agent, relating to the inhibition of fructokinase, it is shown to prevent AKI following contrast or cardiovascular surgery.

Impact: The problem to be solved is to develop a therapeutic means for preventing acute kidney injury (AKI) from contrast and to markedly reduce the risk for AKI following high risk cardiovascular surgery.

BIOSCIENCE COLORADO 2012/2013 43 Investigator: Andrew Thorburn, Ph.D. Investigator: Xiao-Jing Wang, M.D., Ph.D.

Title: Validation and Development of a Six1 biomarker test for Title: Novel Use of an Endogenous Human Protein to Treat Oral cancer treatment Mucositis

Research: The goal of this project is to create a validated, com- Research: The goal of this project is to optimize local Tat-Smad7 mercially viable diagnostic test that can be used to identify tumors protein delivery in animal models to treat severe, painful oral blis- that over-express Six1. The outcome would help physicians to ters (oral mucositis), leading to Tat-Smad7 commercialization for better prescribe cancer treatment. treatment of severe oral mucositis in patients undergoing chemo/ radio-therapy or organ transplant. The researchers have created the Impact: The anticipated response rate predicts ~ 25,000 lung can- Tat-Smad7 recombinant protein that has therapeutic effects on oral cer patients each year in the United States who would benefit from mucositis in mice. treatment. Additionally, it may be viable to develop a routine test that would be performed on patients who are scheduled for treat- Impact: Oral mucositis is a chronic oral ulceration. This disease ment with “standard” chemotherapy agents. The focus is on lung frequently occurs in radiation-treated patients of all cancer types, and ovarian cancer, which represent the most common and deadly patients undergoing radiation treatment for organ transplants and tumor type in both men and women and the most common and patients undergoing routine chemotherapy. Severe oral mucositis deadly gynecological cancer. However because other diseases such is extremely painful and impairs food/liquid intake, hence it is as breast cancer also express Six1, the test could be more widely often the most severe complication of cancer therapy. Currently, applicable making the potential clinical impact even larger. there is no established therapy to effectively treat severe oral mucositis. There is only one FDA approved drug, given through i.v. injections, for severe oral mucositis in bone-marrow transplant Investigator: David Wagner, Ph.D. patients, and its use in cancer patients remains to be determined. Hence, this drug is available for a mere 4% of the at-risk popula- Title: Development of a Drug Substance to Prevent/Reverse Hy- tion. This research will explore local delivery of a different thera- perglycemia in Type 1 Diabetes peutic protein to oral mucositis lesions, which provides stronger therapeutic effects with fewer adverse effects compared to the Research: The goal of this project is to identify a lead compound other drug, and can be used to treat all oral mucositis cases. and any additional patentable compounds for treatment of type 1 diabetes and other autoimmune diseases.

Impact: Diabetes affects over 23.6 million Americans with 5% - UNIVERSITY OF DENVER 10% of those people having type 1 diabetes (T1D). The yearly rate of new T1D diagnoses in the US is estimated to be approximately 30,000 people and growing. The goal is the prevention and rever- Investigator: Siavash Pourkamali, Ph.D. sal of T1D by controlling pathogenic T cells, which heretofore have proven difficult to target. Title: Development of a Nanomechanical Biosensing Platform

Research: The objective of this project is to develop, optimize and demonstrate the basis for a new biosensing platform with fully electronic readout that allows faster and simpler bioanalysis at a much lower cost. The platform will be based on the liquid phase compatible nano-electro-mechanical resonator technology that allows direct real-time measurement of the mass of the absorbed molecules eliminating the need for fluorescent labeling and optical readout setups.

Impact: This technology can potentially lead to much more cost effective and less labor intensive biodetection and medical diagnosis solutions as well as advanced and affordable instruments for molecular biology and biochemical research.

44 2012/2013 BIOSCIENCE COLORADO EARLY STAGE COMPANY AWARDS 2011-2012

Amide Bio, LLC, Louisville The company uses an innovative hybrid technology platform that combines recombinant and chemical methods for the efficient production of high-value peptides and proteins. Grant funds will support technology development for insulin variant peptides, demonstrating the technology to attract other partners.

Carbo Analytics, LLC., Fort Collins The company is working on the commercial development of an online sugar monitor with immediate application for more cost effective biofuels production. The monitoring technology was founded at CSU and is being used to bring valuable and timely information, cost-effectively to the transformation of biostocks into fuels.

Crestone, Inc., Boulder The company is developing a novel antibiotic for the treatment of COMMERCIALIZATION INFRASTRUCTURE AWARDS serious Gram-positive bacterial infections including skin infec- 2011-2012 tions and pneumonia. Biofrontiers Institute at University of Colorado Boulder Flashback Technologies, Inc., Boulder This grant supports the Biofrontiers Institute, formerly the This grant supports the company in developing a robust and ac- Colorado Institute for Drug, Device and Diagnostic Development, curate, non-invasive resuscitation monitor to improve the clinical in developing a state-of-the art research and education facility outcomes for trauma victims experiencing hemorrhage. At project that links the basic sciences, engineering, clinical practice, and conclusion, two devices will be ready for clinical trials. industry at the University of Colorado’s Boulder campus to support breakthrough developments in areas such as engineering OnKure, Inc., Longmont human tissues, RNA enzyme and aptamer based pharmaceuticals, The company is exploring a highly potent and selective HDAC in- biorefining, and genetics. Grant funds support equipment, resources hibitor as an anti-tumor drug. Grant funds will help in identifying and personnel costs to develop the core facilities of the institute. biomarkers associated with HDAC responsiveness and resistance; and in assessing the candidate in preclinical oncology models. CID4 The Colorado Institute for Drug, Device and Diagnostic Develop- Shape Opthalmics, LLC., Aurora ment (CID4) is managing life science discoveries from Colorado This company developed out of technologies founded at the research institutions and Colorado start-ups and early-stage busi- University of Colorado. Grant work will move a punctual plug nesses with the goal of creating bioscience jobs in Colorado. Grant into design freeze stage as the first step toward an FDA 510(k) Funds support operations of the CID4 and the development and submission. The punctual plug is a novel and cost-effective clinical management of life-science discoveries adopted as Projects of the treatment for dry-eye syndrome. The company is also developing CID4. The CID4 currently has 5 Projects, or companies, under its a drug-eluting component for the punctual plug as a glaucoma guidance and has fostered those to create 27 jobs (including indi- treatment. rect) and garnered an additional $1.5 million for these businesses.

Sophono, Inc., Boulder Colorado State University Ventures - Colorado Center for This company has a bone conduction hearing technology, and is Drug Discovery adapting it for the under-age-5 market using technology licensed This grant supports the Colorado Center for Drug Discovery from CU that will allow the company to re-design the device ef- (C2D2) as a resource to faculty at Colorado research universities, fectively. The CU technology will also allow the company to train bringing biology and chemistry faculty together to use chemical providers for proper implantation. libraries, computational resources, bioinformatics, cheminfor- matics, database support, virtual high throughput screening, and SuviCa, Inc., Boulder Computer Aided Drug Design to pharmacologically validate drug Grant funds will support the company in developing their lead candidates with patent-protected chemical matter and innovative candidate for an orphan oncology indication, and in the character- therapeutics for unmet medical needs. C2D2 has established a ization of a follow-on new chemical entity. grant system and supported 6 inter-institutional projects with funding and resources in 2011. In addition to these, C2D2 is providing medicinal chemistry resources to two other investigators, and is expanding its services on a fee basis.

BIOSCIENCE COLORADO 2012/2013 45 Colorado By the Numbers Update on A History of Colorado-Based and Related Public Companies (2007-2011) 1 Accelr8 Technology AMEX:AXK Colorado’s Growing 2 Agilent Technologies NYSE:A 3 Allos Therapeutics NASDAQ:ALTH Bioscience Industry 4 Alpharma Animal Health | NYSE:KG King Pharma 5 Amgen NASDAQ:AMGN 7 Array Biopharma NASDAQ:ARRY 8 AspenBio Pharma NASDAQ:APPY 9 B2 Health NASDAQ:BTWO 10 BioNovo NASDAQ:BNVI Larimer 11 Ceragenix Pharmaceuticals OTC BB:CGXP.OB 19 Weld 12 Cochlear Americas ASX:COH 31 13 Conmed NASDAQ:CNMD 14 Corgenix Medical NASDAQ:CONX.OB

Medical Device 15 Covidien NYSE:COV 23 5 4 Biopharma 16 Dharmacon | Thermo Fischer NYSE:TMO 27 25 Diagnostic 43 32 Scientific 15 GreenBio Boulder28 20 17 Encision NASDAQ:ECIA.OB 2 34 Other 29 17 14 33 24 7 18 GeneThera NASDAQ:GTHR.PK 30 16 21 4035 3 19 Heska NASDAQ:HSKA Broomfield 20 Hospira NYSE:HSP Gilpin 10 18 38 Adams 21 InB:Paxis / Hauser CRO | NASDAQ:INBP 26 1 44 11 Integrated BioPharma 36 Denver 22 Inhibiton Therapeutics NASDAQ:IHBT 12 41 42 22 23 Insmed NASDAQ:INSM 37 13 Arapahoe Jefferson 24 Martek Biosciences NASDAQ:MATK 25 Medtronic NYSE:MDT 26 Mesa Labs NASDAQ:MLAB 39 8 27 Myogen | Gilead NASDAQ:GILD 28 OrthoNextx NASDAQ:ANTX.OB Elbert 29 OSI Pharmaceuticals NASDAQ:OSIP Douglas 30 Pharmion Acquired by Celgene NASDAQ:CELG (PRIVATELY 31 QLT Acquired by Tolmar HELD) NASDAQ:QLTI 32 Replidyne | CardioVascular NASDAQ:RDYN

35 Systems 33 Roche Colorado Acquired by VTX:ROG.VX Teller Corden Pharma 9 34 Sandoz NYSE:NVS 35 Spectranetics NASDAQ:SPNC El Paso 36 The Sorin Group MTAX:SRN.MI 37 VitroLife SEK:VITR 38 Xelr8 Holdings AMEX:BZI 39 Zynex NASDAQ:ZYXI.OB 40 ARCA biopharma NASDAQ:ABIO 41 Omnio Biopharma NASDAQ:OMBP.OB 42 Ampbio Pharmaceuticals NASDAQ:AMPE 43 Clovis Oncology NASDAQ:CLVS 44 Gevo NASDAQ:GEVO 2011

46 2012/2013 BIOSCIENCE COLORADO 1. 3Q Matrix 2. A2BE Carbon Capture 3. Accuthera 4. Advanced Headache Intervention New companies IN COLORADO 2007-2011 5. Advanced Microlabs 6. ApopLogic Pharmaceuticals 7. ArcScan Inc. 8. Beacon Biotechnology 9. BioAMPS International 10. Biodesix 11. BlueSun Larimer Weld 12. Caveo Therapeutics 61 13. Chemizon 14. Clarimedix 17 15. CycleGen 16. EndoShape 5 22 17. Firefly medical 33 48 18. Fluonic 49

19. HepQuant 70 Middlesex County, 25 13 67 20. Hiberna 66 41 39 18 Hopkinton, MA 27 (relocated) 21. Illumasonix 63 2 64 9 22. KromatidTiD 51 Boulder 14 50 26 16 11 10 23. Lanx 65 57 15 23 24. Locomotion 43 24 20 40 19 35 46 25. mBio Diagnostics Broomfield 6 45 8 30 Gilpin 12 34 26. Miragen Pharmaceuticals 62 21 31 36 Adams 52 44 27. OPX Biotechnologies 3 68 32 60 44 47 7 28. Onco Therix 69 71 29. Pico-Tesla Magnetic Therapies Denver 38 29 55 28 Clear Creek 4 59 53 56 30. Precision Biopsy 58 42 Arapahoe 31. Sierra Neuropharmaceuticals Jefferson 32. Snoasis Medical 33. Solix Biofeuls Medical Device 34. Taiga Biotechnologies Biopharma 35. Tissue Genetics Diagnostic 36. ValveXchange Douglas GreenBio 37. V-Clip Pharmaceuticals 54 Other 38. Ventrus Biosciences** 39. Vitrumed Mesa County Grand Junction, CO 40. MycoLogics 41. AmideBio 37 El Paso 42. Analytical Research System 43. InDevR 44. Qgenta 45. Allosgenesis 46. Western States Biopharma 47. Isogenis 48. Tolmar 60. Sharklet Technologies* 49. Biotricity Medical** 61. VetDC

50. Actium Biosystems, LLC 2011 62. PharmaJet 51. Eveia Medical,Inc 63. Flashback 52. Generations Medical Partners LLC 64. InDevR 53. ICVRX LLC 65. Mosaic Biosciences 54. Leap Frogg, LLC 66. Surefire Medical* 55. Myocept 67. Acenta Acoustic Labs 56. Ocutronics, LLC 68. Oberon 57. Sophono 69. PolyNew 58. Peptivir 70. SuviCa 59. Ariel Pharma 71. Great Lakes Pharmaceuticals*

*Company Migrated to Colorado **Company Exited from Colorado

BIOSCIENCE COLORADO 2012/2013 47 Institutional Financings 2007 to 2011 COMPANY ROUND/EVENT VALUE ($M) 1 Accera Series C $35.0 2 Allos Therapeutics Seconday $65.2 52 - Allos Therapeutics Secondary $50.5 57 3 ARCA biopharma Series B 18.0 4 Array Biopharma Debt + Warrants $80.0 Larimer Weld 5 Aspen BioPharma Secondary $18.2

2007-2010 6 BaroFold Series A $12.0 7 Biodesix Series B Undisclosed 8 BiOptix Series B Undisclosed 36 9 CeraPedics Series A $12.3 63 64 10 Evolutionary Genomics Series A $5.0 50 53 55 5860 4435 48 54 62 Medical Device 11 GlobeImmune Series C $41.2 61 16 35 30 11 48 50 38 Biopharma 12 IBalance Medical Series A $13.5 Diagnostic 4735 51 6 24 15 13 Illumasonix Series A Undisclosed 31 17 10 GreenBio 4 19 12 14 Lanx Series A $25.0 32 Boulder 14 Other 15 MD-IT Series B $11.0 59 67 29 8 1 3 3545 11 18 51 34 53 49 52 28 22 16 Microphage Series A $11.0 4635 39 9 7 2 66 4335 41 17 Miragen Series A $8.0 Broomfield 25 23 37 18 N30 Pharma Series A Undisclosed Gilpin 13 21 40 Adams 19 OPX Biotechnologies Series A $3.6 33 5649 65 20 OberonFMR Series A $1.0 27 20 21 Precision Biopsy Series A Undisclosed Denver 22 Range Fuels Series B $130.0 Clear Creek 23 Sierra Neuropharma Series A $21.5 Arapahoe Jefferson 24 SomaLogic Series D $35.0 25 Taligen Therapeutics Series B $65.0 26 TheraTogs Series A $1.1 27 Luca Technologies Series C $76.0 5 Colorado 28 Medivance Series E $8.1 42 29 Clovis Oncology Series A $146.0 26 San Miguel County, Douglas 30 OPX Biotechnologies Series B $17.5 Telluride, CO 31 CeraPedics Series B $14.5 32 BiOptix Series A $3.0 33 AmideBio Seed Undisclosed 34 GlobeImmune Series E $17.5 35 GlobeImmune Milestone payment $40.0 36 Inviragen Series A $15.0 37 Sharklet Series A $1.5 57 Precision Biopsy Series A $2.50 38 miRagen Series A2 $4.0 58 PanTheryx Series A $1.00 39 Array Biopharma Debt + Warrants $40.0 59 BiOptix Series B $9.00 40 BioAMPs Seed $0.1 60 EndoShape Series B $3.50 41 Allos Therapeutics Secondary $93.0 61 OPX Biotechnologies Series C $36.50 42 AspenBio Pharma Secondary $8.7 62 Ampio Pharma Secondary $9.50 43 Accera Series D $11.0 63 Accera Series D $11.00 44 SomaLogic Series E $15.0 64 Biodesix Series D $20.00 45 Biodesix Series C $7.1 Sub-total | Capital Raises (disclosed) $1,625.08 46 GlobeImmune Series E $17.5 65 Dharmacon Acquired $80.00 47 N30 Pharma Series B $17.5 66 Sima Acquired $1,100.00 67 Pharmion Acquired $2,900.00 48 Clovis Oncology IPO $130.00 68 Myogen Acquired $2,500.00 49 Gevo IPO $123.30 69 RxKinetix Acquired $115.00

2011 50 Miragen License Agreement $45.00 70 Insmed Acquired $130.00 51 ARCA biopharma Secondary $3.00 71 Taligen Therapeutics Acquired $111.00 52 AmideBio Seed $0.58 72 CaridianBCT Acquired $2,600.00 53 ValveXchange Series A $3.50 73 Baxa Acquired $380.00 54 St. Renatus Series A $3.50 74 Medivance Acquired $250.00 55 Mosaic Biosciences Series A $1.00 Sub-total | Exits $10,166.00 56 Surefire Medical Series A $6.10 Total | Capital Infused to Colorado $11,791.08

48 2012/2013 BIOSCIENCE COLORADO DIRECTORY

Actall Security Products Denver INDEX www.actallsp.com Engineers, manufactures and markets wireless systems 48 Medical Device and Related Companies for hospital and pharmaceutical company facilities.

57 Biotechnology, Pharmaceutical and Advanced MicroLabs, LLC Fort Collins Related Companies www.advancedmicrolabs.com Researches and develops chemical analytical instru- 62 Biofuels and Related Companies ments in ‘Lab-on-a-chip’ format. Advanced Research Instruments Corporation 63 Research & Education Institutions Golden www.aricorp.com 65 Foundations Produces preamplifiers for PMT’s and electron multipliers, high voltage power supplies, counters and 65 Service Providers timers, precision rate meters, and image analyzers for scanning electron microscopes. preamplifiers

Aerophase, Inc. Longmont www.aerophase.com Research and Development of technologies that reduce Medical Device and Related Companies environmental impact, help economically disadvan- About Packaging Robotics taged people, and improve healthcare. Including low 2C Technologies Thornton cost, environmentaly friendly Meter Dose Inhaler and Denver www.aboutpackagingrobotics.com iproved Aerosol Therapy for Lung Cancer www.2ctechcorp.com Produces robotic package handling systems. The Development, validation, and commercialization of products are engineered to open, fill, transport, seal, Aesthetic Technologies “SeeQ” intraocular implant as a next generation in vivo code and label a variety of pre-made pouches and bags. Golden system for stimulating degenerated retinal cells and Their line of packaging and systems for on demand www.parisianpeel.com restoring vision. product identification are currently used in the medical, Manufactures and sells Parisian Peel® brand micro- industrial and food industries. dermabrasion systems and accessories along with skin Abilities Unlimited care products to medical, and spa professionals. Colorado Springs, Denver Accellent Skin Care www.auiop.com Arvada, Englewood Provides artificial limbs and custom orthopedic appli- www.accellent.com Aestis, Inc. ances. Accellent is the best provider of comprehensive supply Boulder chain solutions, and we are always striving to be more www.altitudetraining.com/aux/about/aestis Able Planet responsive to our partners. With our Accellent Focus Develops a treatment for obesity through controlled Wheat Ridge we continue aiming at doing just that. hypoxia technology. The two principal components are www.ableplanet.com the air separation unit and proprietary control system. Developing an extensive line of audio and Accelr8 Technology Corporation communications products that are usable by people Denver Agilent Technologies with all levels of hearing, and provide a means www.accelr8.com Englewood whereby users can listen at lower volumes without Develops medical diagnostic technologies for research www.agilent.com compromising full rich sound. and clinical applications. The primary focus is rapid, in- Provides core electronic and bio-analytical measure- tegrated bacterial analysis system designed to identify, ment tools to advance life science research. AbleLink Technologies count, and provide complete antibiotic susceptibility Colorado Springs data by bacterial species within a few hours of sample AktiVa www.ablelinktech.com injection without prior culturing. Boulder/Aurora Addresses the need for well-researched cognitive www.aktivax.com support technologies for individuals with intellectual Accu-Tube Corporation Developing novel reconstitution, safety syringes for disabilities. Englewood vaccines and biologics. intellectual disabilities www.accutube.com Manufactures standard and custom size stainless steel Allergan, Inc. hypodermic medical tubing. Denver www.allergan.com Acertara Acoustic Laboratories, LLC Continually conduct research to develop products that Longmont enable medical specialists to help people preserve and www.acertaralabs.com protect their vision, move freely, best express their in- Independent ISO/IEC accredited medical ultrasound ner beauty and lead healthy and active lives. COLORADO BIOSCIENCE ASSOCIATION MEMBER acoustic measurement and testing laboratory.

BIOSCIENCE COLORADO 2012/2013 49 Medical Device and Related Companies

Allison Medical Inc ArcScan, Inc. Bell Dental Products, LLC Littleton Morrison Englewood www.allisonmedical.com www.arcscan.com www.belldental.com Develops products to assist specialists in the medical ArcScan, Inc. has developed break though imaging Designs, develops, and manufactures precision dental and veterinary industries, and have designed and technology for the eye. Many ophthalmologists feel equipment based on electric motor technology. provided essential syringes, needles and custom items its patented Artemis 3 (shown above) VHF Ultrasound for various industries. Arc Scanner will change ophthalmology the way MRI BiO2 Medical, Inc changed radiology. Golden Allogenesis LLC www.bio2medical.com Denver Arcturus Star Products LLP Medical device manufacturer founded to design, www.genbiomed.com Cortez develop, and subsequently manufacture a range of Created purified human platelet mixture from platelets www.arcturusstar.com medical products in response to clinical needs. contained in blood (from blood banks) that holds prom- Arcturus Star Products is dedicated to pioneering ise to replace current growth media for stem cells. The Vibrational Energy Therapy for the wellness and beauty BioCare Systems, Inc. company’s pHMP product promises to offer researchers professions. Vibrational energies incorporate subtle low Parker more affordable animal-free option capable of working frequencies of light, sound, and electrical waves. Their www.biocaresystems.com across applications. therapeutic specialty is in the area of lymphatic health. Designs, develops and markets patent-protected, FDA cleared, new health-care devices (LumiWave™) that AlloSource ASI Medical, Inc. use deep-tissue light therapy to decrease pain, acceler- Centennial Centennial ate healing and improve quality of life. www.allosource.com asimedical.net Develops, processes and distributes life-enhancing Developer of specialized mobile and integrated dental Biodesix, Inc. bone and tissue allografts to the medical community. carts, as well as unique dental instruments for the Aurora, Broomfield bone; tissue; modern dental office. www.biodesix.com Provides clinically reliable methods for the early detec- AllPro Aspire Biotech, Inc. tion, diagnosis, therapeutic guidance, and monitoring in Broomfield Colorado Springs cancer and degenerative diseases. www.allprodental.com www.aspirebiotech.com Produces a large selection of non-latex prophy cups, Provides contract services for all phases of product Bio-Logistics Preclinical, Inc. prophy angles and other dental products. development from concept to launch, and produces its Pierce own skin sealant and wound-closure adhesives. www.bio-logistics.com Alpha Mold West Offers engineering and regulatory support and pre- Broomfield Auri-Stim Medical clinical strategic development to the medical device www.alphamoldwest.com Denver industry. Plastic injection mold-making facility for the medical www.net1device.com industry. Offers an alternative therapy for migraine headaches, BiOptix hormonal migraine, chronic headaches, premenstrual Boulder Angioslide, Inc. syndrome (PMS), nicotine and narcotics addictions www.bioptixinc.com Wheat Ridge using the NET-1000 device. Offers a new, patented approach to label-free analysis, www.angioslide.com called Surface Plasmon Enhanced interferometry Privately held medical device company that devel- Avantes (SPE). oped a unique Embolic Capture Angioplasty solution, Broomfield PROTEUS™, which provides a combination of PTA www.avantes.com Biotricity Medical Inc. balloon and embolic capture. Produces, develops and sells spectrometers, light Aurora sources, fiber optic multiplexer, fiber optic cables, www.biotricitymedical.com Animal Care Systems, Inc. software, fiber optics, accessories to the medical device Research and manufacturing company specializing Centennial industry. in developing long-term power requirements for im- www.animalcaresystems.com planted devices based on bioelectric generation. Provides innovative rodent caging systems for the life- Bal Seal Engineering, Inc. science industry. Colorado Springs BioVision Technologies, Inc. www.balseal.com Golden Animark, Inc. Produces seals and canted-coil springs for sealing, www.biovisiontech.com Aurora holding, latching, and electrical contact in a variety of Develops and manufactures micro-visualization solu- www.animark.us applications throughout the medical market. tions that enable endoluminal and minimally invasive Manufactures and sells ultrasound pregnancy detectors medical procedures in both human and veterinary and ovulation predictors for livestock breeding. Baxter Healthcare Corporation medicine. The imaging technologies and customized Englewood micro-endoscope solutions are integrated to reduce Apdyne Medical Company www.baxter.com incision size and speed healing. Denver Baxter International, through its subsidiaries, develops, www.apdyne.com manufactures and markets products that save and BodySync, Inc. Manufactures and distributes the Apdyne Phenol Ap- sustain the lives of people with hemophilia, immune Aurora plicator Kit used to anesthetize the tympanic mem- disorders, infectious diseases, kidney disease, trauma, www.bodysync.com brane during in-office myringotomy procedures. and other chronic and acute medical conditions. Applies evidence-based genetic information to develop personalized products that help individuals achieve Aqueous Biomedical Beacon Biotechnology their health goals. Colorado Springs Aurora www.aqueousbio.com www.beaconbiotechnology.com Boulder Diagnostics Develops biocompatible materials and geometric BP Proteomics, ProLume Ltd, and Black Forest Boulder designs that can be applied to stents, shunts, artificial Engineering, LLC have come together to create Beacon www.boulderdiagnostics.com organs and drug delivery devices. Their first product, Biotechnology to pursue new opportunities that build Boulder Diagnostics is a specialty diagnostics company the Oculieve™ shunt, is designed to control over- upon their respective scientific expertise. dedicated to developing diagnostic reagents and test pressurization inside the eye caused by glaucoma. for infectious diseases and other protein targets that Beckman Coulter can benefit from a reliable, easy to use test for labora- Fort Collins tory, physician’s office or home use. We focus on www.beckmancoulter.com underserved markets where the current state of the art Develops and produces instruments for the diagnostic is inadequate for effective diagnosis. industry. Specializes in the fields of immunocytochem- istry, flow cytometry, and microbiology.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

50 2012/2013 BIOSCIENCE COLORADO Medical Device and Related Companies

Boulder Innovation Group, Inc. CereScan Colorado Precision Products, Inc. Boulder Denver Boulder www.boulderinnovators.com www.cerescanimaging.com www.coloradoprecision.com Develops and manufactures image-guided surgical Specialize in state of the art functional brain imaging Provides diamond turned and polished optics/parts. navigation digitizers and industrial 3D capture and utilizing a proprietary process including the latest gen- Fabricator of X-ray telescope optical components. modeling equipment. eration high resolution gamma camera, the industry’s Produces and offers air bearing LVDT contact linear leading brain image reconstruction software, specially measurement systems, .05 microinch resolution. Broadwest Corporation trained board-certified physicians and research-based Denver knowledge to provide unparalleled diagnostic medical COMEG U.S.A. Endoscopy, Inc. www.broadwest.com reports. Denver Develops and manufactures ergonomic mammography www.sopro-comeg.com viewing equipment. Certol International, LLC A product range producing high quality video imagery Commerce City that meets the needs of the surgeons in terms of prod- C5 Medical Werks www.certol.com ucts, budget and services, whatever their specialty. Grand Junction Provide patients and healthcare professionals with www.c5medicalwerks.com innovative products and responsible solutions to the Confi-Dental Products Company Offers ceramic manufacturing, materials expertise, and complicated infection control challenges of the 21st Louisville custom engineering support to prototype and commer- century. www.confi-dental.com cialize designs and patents to orthopedic companies for Manufacture a wide range of dental and healthcare hip, spinal and dental implants. Clarimedix products including composites, cements, creams, lo- Boulder/ Aurora tions & ointments. Canberra Industries www.clarimedix.com Greenwood Village Leading medical device company targeting vascular CONMED Electrosurgery www.canberra.com dysfunction in Alzheimer’s disease with a non-invasive, Centennial Manufactures and supplies analytical instruments, non-drug therapeutic approach. The product uses an www.conmed.com systems and services for radiation detection and radia- innovative new technology platform to provide signifi- Designs and manufactures RF electrosurgical generation monitoring. cant cognitive benefit without the side effects seen with tors and accessories of the highest quality, safety and current treatments. The result is a product that has the value for use in surgical procedures performed in Car-May L.L.C. potential to revolutionize treatment options for patients virtually every hospital, surgery center and physicians Berthoud and families. office. www.car-may.com Unlike basic metering pumps, Car-May’s systems pro- Clean Room Devices, LLC CoorsTek vide pumping capability, fluid measurement, and flow Westminster Golden control all in one compact module. www.cleanroomdevices.com www.coorstek.com Manufactures products that are engineered specifically Using our core strengths of custom engineering, Care Electronics, Inc. for “clean room” environments. materials expertise, operational excellence, and rapid Boulder execution, we help our customers develop amazing www.medicalshoponline.com Clifford Consulting & Research, Inc. solutions to their toughest technical challenges. Our Offers a range of electronic monitoring and alarm Colorado Springs experienced engineering and manufacturing experts are equipment for the home health and long term care www.ccrlab.com ready to help with your next project. markets. Clifford Materials Reactivity Testing (CMRT) is a laboratory screening process used to help identify exist- Corgenix Medical Corporation Caroba Plastics, Inc. ing sensitivity problems to various chemical groups and Broomfield Englewood families of compounds in an individual patient. www.corgenix.com www.caroba.com The Colorado facility is engaged in research, develop- Provides custom injection molds and specializes in the Cochlear Americas ment, manufacture, and marketing of in vitro diagnostic needs of the medical and high technology industries. Centennial products for use in disease detection and prevention. www.cochlearamericas.com Carsan Engineering, Inc. Designs, manufactures and distributes hearing implants Covidien Golden including the Nucleus Freedom and Baha implants. Boulder www.carsaneng.com www.covidien.com Designs and manufactures products for several of the ColdQuanta, Inc. Offers an extensive product line, including pulse leading OEMs in the medical, dental, industrial, semi- Boulder oximetry and airway and temperature management conductor, entertainment, and video projection markets. www.coldquanta.com devices, ventilators, vessel sealing, and electrosurgery Focuses on the development of BEC (Bose-Einstein equipment. Cascade TEK Condensate) generating devices and systems, allowing Longmont them to be accessible to a wide range of research, edu- Crosstrees Medical, Inc. www.cascadetek.com cational, and industrial institutions. Our products are Boulder Cascade TEK is an accredited medical device testing intended for use in scientific and industrial applications www.crosstreesmedical.com laboratory located in Longmont CO and Oregon. requiring high performance and reliability. Privately-held company developing advanced devices Specializing in package testing, accelerated aging, and instruments for the treatment of vertebral body photostability, UV, temperature/humidity, vibration, Colibri Heart Valve compression fractures (VCF) in the spine. shock testing services. Broomfield www.colibrihv.com Chart Denver CEA Technologies, Inc. Colibri Heart Valve, LLC is engaged in research and Denver Colorado Springs development of novel heart valve technologies. The www.chartindustries.com www.ceatechnologies.com company has developed proprietary processes of tissue Chart Denver provides manufacturing services to Provides product development and complete product membrane preparation and treatment as well as unique companies who want to out-source some or all of assembly and packaging services to the medical geometries for heart valve design exploiting concepts their manufacturing processes, and to companies that industry. of strength and durability through material continuity have capacity issues with their current manufacturing enabled by folded membrane constructs. resources. CeraPedics, Inc. Westminster Colorado Laser Technologies, Inc. C. R. Bard, Inc./ Medivance www.cerapedics.com Colorado Springs Louisville Globally supplying the orthopedic and spinal commu- www.coloradolasermarking.com www.crbard.com nities with quality products, services and educational Provides YAG laser engraving technology, as well as C. R. Bard, Inc. headquartered in Murray Hill, NJ, is opportunities to improve patient outcomes CO2 and YAG laser cutting services. a leading multinational developer, manufacturer and marketer of innovative, life-enhancing medical technologies in the fields of vascular, urology, oncology and surgical specialty products.

BIOSCIENCE COLORADO 2012/2013 51 Medical Device and Related Companies

CytoLogic Inc. dpiX, INC. Eveia Medical Boulder Colorado Springs Boulder www.cytologic.com www.dpix.com www.eveiamedical.com Commercialization of an immunotherapy device for Produces high-resolution amorphous silicon (a-Si) sen- Development stage company focused on creating a bio- treatment of cancer. sor arrays for medical X-ray imaging. analytical system designed to conduct immunassay tests. Ky attributes include; lowfemtomolar sensitivities, short Darkhorse Technologies E.I. Medical Imaging assay development cycles and results in 10-20 minutes. Boulder Loveland The product consists of the instruments, software and [email protected] www.eimedical.com reagents required for analyte measurement. Commercializes a patented technology for affordable, Manufacturer of highly portable and ruggedized ultra- hand-carried, battery operated instruments for on-site sound devices for the veterinary industry. Extreme Diagnostics genetic detection using Polymerase Chain Reaction Boulder (PCR). Eldon James Corporation www.extremediagnostics.com Loveland Develops noninvasive measurement systems, includ- DataWave Technologies Corporation www.eldonjames.com ing optical systems such as custom holographic and Berthoud Designs and manufactures a diverse line of plastic and interferometric instruments. Specializes in structural www.dwavetech.com stainless steel hose fittings with a single-barb design. health monitoring, nondestructive testing, and materials Manufactures a wireless and battery-free device for processing. acquiring and transmitting data from electrodes and Electronic Materials, Inc. (EMI) other biosensors to a receiver placed meters away for Breckenridge Falcon Rehabilitation Products electrophysiology, neurophysiology and physiology www.emiuv.com Denver related research on both humans and large animals. Offers a complete line of EMCAST UV adhesives, www.falconrehab.net epoxies, sealants, encapsulants and coatings, EMI also Designs and builds high quality, innovative quadriple- dBMEDx offers room temperature, thermal and Visible light cure gic seating systems and accessories (Falcon Rehabilita- Littleton adhesive systems. tion Products, LaBac Seating Systems, Gel Ovations). www.dbmedx.com Developing next-generation, automated, wireless 3D Ellab, Inc. Firefly Medical, Inc. ultrasound devices based upon our patent-pending full- Centennial Fort Collins view architecture. www.ellab.com www.fireflymedicalinc.com Manufactures thermal validation solutions for food and Designs and develops innovative durable medical DCS Surgical pharmaceutical industries. equipment for clinical healthcare markets. Boulder www.dfjmercury.com Empirical Testing Corporation Fischer Medical Technologies, Inc. Early stage company formed to evaluate potential new Colorado Springs Broomfield surgical procedures for the treatment of sinusitis. www.empiricaltesting.com www.fischermti.com Provides medical device testing services that add value Designs, manufactures, and markets imaging systems Denver Instrument Company throughout the product development cycle, with a focus for the screening and diagnosis of breast cancer. Arvada on spinal implant device testing. cancer www.denverinstrumentusa.com Designs and manufacturers analytical balances, electro- Encision, Inc. FlashBack Technologies chemistry instruments, moisture analyzers, and titration Boulder Longmont controllers. www.encision.com www.flashbacktechnologies.com Designs and manufactures innovative surgical devices. Fast, non-invasive detection of acute blood loss volume Denver Optic Company Developed AEM® Laparoscopic Instruments to im- and prediction of cardiovascular collapse in emergency Englewood prove electrosurgery and reduce the chance for patient situations. www.eyeprosthetics.com injury in minimally invasive surgery. Specializes in the fitting and fabrication of two types of Fluonic ocular prosthesis. EndoShape, Inc. Boulder Boulder/ Aurora www.fluonic.com Desert Glass Works www.endoshape.com Develops infusion therapy systems with disposable Colorado Springs Manufactures surgical and medical instruments focus- sensors for OEM and proprietary pumping systems. www.dgw.com ing on shape memory polymer devices for endolume- Manufactures quartzware for the medical and research nal application. Futura Surgical Inc. industries. Wheat Ridge Enplas Corporation www.futurasurgical.com Diazamed Colorado Springs Development, manufacture and sales of orthopedic Fort Collins www.enplas.com products www.diazamed.com Enplas is striving to gaze into the future through “OPT- Development of advanced materials and utilize leading PLANICS”: a new concept that fuses the latest optical Gambro Americas technologies to create more biocompatible surfaces. and electronics technologies on the basis of engineer- Lakewood ing plastics, the highly functional materials that Enplas www.gambro.com Die Cut Technologies has been pursuing since its inception. Develops and supplies hemodialysis, peritoneal dialysis Northglenn and acute dialysis products, therapies and services. www.diecuttech.com es2 TECHNOLOGIES, INC. Offers precision material conversion, skilled assembly Englewood GE Analytical Instruments and manufacturing efficiencies, including cleanroom www.es2technologies.com Boulder facilities. Product design group that specializes in bringing www.geinstruments.com concepts to life through an inter-disciplinary system Manufactures instruments used to measure total Directed Energy Solutions engineering, product safety and manufacturing engi- organic carbon (TOC) in water for pharmaceutical ap- Colorado Springs neering team. plications and medical research. www.denergysolutions.com Develops advanced laser and optical device solutions Evergreen Research, Inc. Genesee BioMedical, Inc. for medical applications. Golden Denver www.evergreenresearch.com www.geneseebiomedical.com DNTLworks Equipment Corporation Offers a complete range of development services Manufactures cardiac surgery instruments and devices. Centennial from product definition and feasibility studies through www.dntlworks.com detailed design to pilot-run and low-volume production Gnathodontics, Ltd. Manufactures portable, mobile and self-contained to the medical device industry. Lakewood dental systems. www.gnatho.com Specializes in functional dentistry, advanced implant work, precision partial dentures, combination cases and COLORADO BIOSCIENCE ASSOCIATION MEMBER metal-free fixed restorations.

52 2012/2013 BIOSCIENCE COLORADO Medical Device and Related Companies

Grant Dental Technology Corporation InVitria Magnelab, Inc. Colorado Springs Fort Collins Longmont www.grantdentaltech.com www.invitria.com www.magnelab.com Dental implants and surgical/restorative tools. InVitria develops, manufactures and markets a Manufactures custom magnetic components (trans- portfolio of high performance and well defined cell formers/inductors) for the medical field. Hach Company culture products and reagents used in bioprocessing, Loveland biopharmaceutical formulation, stem cell & regenera- Massively Parallel Technologies, Inc. www.hach.com tive medicine, life science research and diagnostics. Boulder Manufactures and distributes analytical instruments www.massivelyparallel.com and reagents used to test the quality of water and other IPAX, Inc. Focuses on the entire communication task at the cluster aqueous solutions. Englewood level, and optimize it mathematically (22 patents www.ipaxinc.com granted or pending); Rigorous algorithms allow a HEI Advanced Medical Operations Assembles and packs medical products, focusing on system to manage itself and adapt to changing require- Boulder bringing new medical products to the marketplace. ments, at any scale; Libraries self-train on a given www.heii.com Specialty is small to medium production runs, also has hardware configuration, so there is no tradeoff between Develops and manufactures high performance the capacity and the manpower to take on the larger optimality and generality. components, medical software, medical devices, and jobs. non-medical products. Produces microcircuits and Mayer Medical Technologies, Inc. subsystems for hearing and medical applications. Jorgensen Laboratories, Inc. Grand Junction Loveland www.mayermedical.com Hirsh Precision Products, Inc. www.jorvet.com Mayer Medical Technologies, Inc. improves health Boulder Designs and manufactures instruments which are used and saves lives by innovating new products, providing www.hppi.com in the animal health field including specialty instru- seed capital to medical start-ups, and assisting medical Manufactures precision-machined and assembled ments, surgical suture, and veterinary equipment. professionals in developing their product ideas. components for the medical industry. Kent Systems mBio DIAGNOSTICS Illumasonix LLC Loveland Boulder Aurora www.kentsystems.com www.mbiodx.com www.alliedminds.com/subsidiaries/ilumasonix KENT Systems designs, manufactures, and distributes Develops a low-cost, high sensitivity, multi-pathogen In partnership with Allied Minds, we will develop and Plastic Quick Couplings, Tube Fittings, and Media detection system for diagnostics. commercialize a new non-invasive vascular disease Bags. detection procedure which will provide near real-time MedEfficiency, Inc. assessment of detailed blood flow patterns within the Kestrel Labs, Inc. Wheat Ridge cardiovascular system. Boulder www.medefficiency.com www.kestrellabs.com Specializes in total contact casting products for off- Imagistx, Inc. Kestrel Labs combines internal research and develop- loading diabetic foot ulcers. Highlands Ranch ment projects with consulting and contract develop- www.ImagistxProstate.com ment of innovative, patient monitoring concepts and Medical Modeling, Inc. Ultrasound system that is potentially able detect and other medical technologies. Golden target for biopsy and focal therapy prostate cancer. www.medicalmodeling.com Lanx, LLC Produces highly accurate 3-D physical models of hu- InDevR, Inc. Broomfield man bone structure from imaging such as CT or MRI. Boulder www.lanx.com www.indevr.net Specializes in systems and implants for all segments Medtronic Navigation, Inc. Develops and manufactures biomedical instru- of spinal surgery. Integrating leading technology, intel- Louisville ments including molecular diagnostic assays, virus lectual property and state-of-the-art engineering, each www.medtronicnavigation.com measurement systems and detection technologies for product is designed to simplify surgery and improve At the forefront of surgical navigation solutions, guid- micro-arrays. the quality of care for patients worldwide by providing ing the industry to a higher standard of care for several surgeons with innovative spinal products. clinical specialties, including cranial neurosurgery, Infinity Photo-Optical Company functional neurosurgery, spinal, ENT, joint replacement Boulder Leap Frogg, LLC and orthopaedic trauma surgeries. www.infinity-usa.com Grand Junction Manufactures long-distance and continuously-focus- 970-260-7494 Meinhard Glass Products able microscope technology, macro systems, internal- Created The Frogg® Dynamic Compression System Golden focusing devices and other lenses. which Can Be Used at All Times; No Gaps in Protec- www.meinhard.com tion; Reduces Accidents; Reduces Nursing Time; Is Continues the evolution in nebulizer design. The Injectech, LLC More Comfortable; principle goal is to produce finer, more narrowly sized- Loveland dispersed aerosols while maintaining the high quality, www.injectech.net Leeds Precision Instruments, Inc. low cost and simplicity of design and operation that Provides molding, assembly and design of medical Denver characterize the MEINHARD® nebulizer. components and fittings for OEM device manufactur- www.leedsmicro.com ers. Class 100,000 cleanroom molding and assembly Offers microscopes and custom-engineered products Mesa Laboratories, Inc. available. ranging from small modifications on a microscope Lakewood stand that accommodate specific applications, to large www.mesalabs.com Instec, Inc. specialized systems, such as an optical comparison Provides dialysis meters and related supplies to dialysis Boulder bridge for forensic science. clinics world wide. www.instec.com Manufactures precision temperature controllers and Lenox MacLaren Surgical Instruments Metamatrix, LLC microscope hot stage systems for temperature cycling, Louisville Boulder food sciences, materials characterization, forensics, www.lenoxmaclaren.com www.zorbent.com polymers and liquid crystals and microbiology. Manufactures precision orthopedic and neurological Manufacturers of ZORBENT which absorbent is de- surgical instruments. signed to leave no residue, reducing the risk associated Intertek with slippery surfaces and is completely safe to use and Boulder Logisens Corporation represents no health hazard www.intertek.com Fort Collins Offers testing, inspection and certification of products, www.logisens.com Micro Imaging Solutions, LLC (MIS) commodities and systems for medical devices. Per- Develops biosensor and software technology, enabling Englewood forms FDA 510(k) reviews, electrical safety certifica- a significant breakthrough in real-time measurement www.micro-imaging.us tion including CE Marking, testing to the MDD and and reduction of stress. Developed an innovative-patented technology that can IVDD, risk analysis, EMC and performance testing. be utilized in the manufacture of micro-digital CMOS cameras.

BIOSCIENCE COLORADO 2012/2013 53 Medical Device and Related Companies

Microlife Medical Home Solutions, Inc. Olympus Soft Imaging Solutions Corporation (OSIS) Pernicka Corporation Golden Lakewood Fort Collins www.mimhs.com www.soft-imaging.de www.pernicka.com Microlife Medical Home Solutions is dedicated to Produces, markets, and sells image acquisition and pro- Offers analytical testing that meets or exceeds the meeting the needs of healthcare providers and their cessing software and hardware for all areas of electron requirements of MIL-STD 750/883 method 1018 and busy medical practices. Our proprietary hand-held microscopy. 45662A for companies in the semiconductor, aero- medical devices and systemic solutions offer healthcare space, basic & applied research, surface analysis, thin providers evidence-based and practice-tested methods Optibrand Ltd., LLC film deposition, laser technology, and medical products for accurate assessment, diagnosis, and treatment of Fort Collins industries. cardiovascular and metabolic diseases. www.optibrand.com Developed optical imaging system for veterinary PharmaJet, Inc. MicroPhage, Inc. diagnostics Golden Longmont www.pharmajet.com www.microphage.com OptiEnz Sensors Develops a needle-free technology that has a low cost, Produces high-speed bacteria detection technologies Centennial single use, disposable polypropylene vial or cartridge, to commercialize in markets including: food safety, www.optienzsensors.com suitable for the delivery of common vaccines and water safety, clinical and veterinary diagnostics and OptiEnz has revolutionized measurement capabilities standard dose injectable liquid medicines. detection applications. for organic chemical concentration; now providing continuous, real-time, in-place sensor solutions. Phillips Plastics (Farley Sales Group) Mikron Corporation Denver Denver Aurora Otologics, LLC www.phillipsplastics.com www.mikron.com Phillips Plastics Corporation offers injection molding Supplies transfer machining systems for complex parts, Boulder cutting tools with high performance standards, self www.otologics.com from design through distribution medication and diagnostic devices. Develops and commercializes surgically implantable alternatives to conventional “in the ear” hearing aids. Physical Activity Innovations Mind Studios Fort Collins Colorado Springs Oval Window Audio Developing unique, footwear-based systems that moti- www.mind-studios.com Nederland vate users to increase their daily physical activity. A full service product design and research studio www.ovalwindowaudio.com housed within the University of Colorado at Colorado Produces induction loop assistive listening systems and Pico-Tesla Magnetic Therapies, LLC Springs. Offers concept generation, advanced proto- visual and vibrotactile technologies that help deaf and Littleton typing, engineering and consumer research, human hard of hearing individuals. www.pico-tesla.com factors design and manufacturing solutions. Manufactures, markets and supports proprietary medi- Paré Surgical, Inc. cal device technology designed to treat the signs and MuscleSound, LLC Centennial symptoms of neurological disorders like Parkinson’s Denver www.paresurgical.com disease, Alzheimer’s, migraines and epilepsy. Developed a process to measure muscle glycogen con- Develops surgical instruments such as the Quik-Stitch tent real time using non-invasive ultrasound technology. endoscopic suturing system. Plexus Corporation Louisville Mitomics (USA) Inc. Parker Medical www.plexus.com Aurora Highlands Ranch Provides integrated product development, manufactur- www.mitomicsinc.com www.parkermedical.com ing, and sustaining services of medical products. Pioneering the development of molecular tests based Provides airway management products that make intu- on the mitochondrial genome in order to improve clini- bation safer for the patient and easier for the medical PolyNEW, Inc. cal insight and therapeutic decisions that affect patients professional. Golden worldwide. www.polynewinc.com Particle Measuring Systems Develops Polymer ice and methods of making and nSPIRE HEALTH, INC. Boulder using them. Longmont www.pmeasuring.com www.nspirehealth.com Designs, manufactures, and services precision Porta-Lung, Inc. Develops, manufactures and markets respiratory care microcontamination monitoring instrumentation Lakewood products and services focused on cardiopulmonary and software used for detecting particles in aerosols, www.portalung.com diagnostics, respiratory core lab services, and disease liquids, slurries, gas streams and vacuum processing Provides non-invasive ventilator support for long-term management solutions. environments as well as surface molecular contamina- patients who need more portability than the iron lung tion monitoring. allows, while maintaining the same level of ventilating NEBA Health LLC efficiency. Boulder PCC/Advanced Forming Technology www.nebahealth.com Longmont Precision Biopsy Develops neuropsychiatric medical devices, such as www.pcc-aft.com Aurora Neba™ an experimental, small format EEG-based Offers thixoforming and metal injection molding for In partnership with Allied Minds, we are working to device being studied under an Investigational Device the medical device industry. develop and commercialize technology for the accurate Exemption from the Food and Drug Administration. diagnosis of prostate cancer which uses advanced Peak Robotics, Inc. spectroscopy imageing techniques in combination with Neuro Assessment Systems Colorado Springs tissue biopsy. Denver www.peakrobotics.com cancer www.neuroassessments.com Manufactures robots, special equipment, and turnkey Provides an objective brain-based measure of automated systems for a variety of industries including: Precision Diagnostic Instruments neurocognitive symptoms associated with a wide biotech, electronics, medical, semiconductor, etc. range of brain health issues including concussion and Westminster Alzheimer’s disease. www.pdimeters.com Peddle Master, Inc. Designs and manufactures professional quality, afford- Johnstown able test equipment. www.peddlemaster.com Designs and manufactures handicapped driving aids. Precision Glassblowing The Peddel Master is totally portable and can be Centennial installed and removed in a matter of seconds. www.precisionglassblowing.com Provides custom and OEM scientific glass for custom synthesis, pharmaceutical, environmental, petrochemi- cal, research, commercial, government and medical laboratories.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

54 2012/2013 BIOSCIENCE COLORADO Medical Device and Related Companies

Precision Photonics Corporation RJD Machining Sharklet Technologies, Inc. Boulder Parker Aurora www.precisionphotonics.com www.rjdmachining.com www.sharklet.com provide price-competitive laser optics and coatings to Specializes in precision production runs and some Engineers surface technologies (Sharklet™) that con- the telecommunications, defense, aerospace, biomedi- prototype work for OEM’s in the medical industry. trols the growth of dangerous bacteria. cal, and semiconductor industries. Rocky Mountain Instrument Company (RMI) Shippert Medical Technologies Corporation Preferred Medical Products, Inc. Lafayette Centennial Englewood www.rmico.com www.shippertmedical.com www.preferredmedicalproducts.com Designs and manufactures optics and coatings (ultra- Manufactures and distributes medical disposable Manufactures stainless steel medical components for violet through far infrared) for the medical industry. products and instruments. Serves the ear, nose and hypodermic needles and lancet type products. throat, plastic surgery, cosmetic surgery, emergency/ Rocky Mountain Orthodontics, Inc. (RMO) trauma care, family practice, pediatric, ophthalmology Prescott’s2, Inc. Denver and dermatology fields. Monument www.rmortho.com www.surgicalmicroscopes.com Serves all areas of orthodontics including pediatric Sienco, Inc. Provides reconditioned operating microscopes and orthodontic prevention, interceptive pediatric orthodon- Arvada allied accessories that function as intended by the tics, mixed dentition orthodontics, adult orthodontics, www.sienco.com original equipment manufacturer. reconstructive dentistry orthodontics, TMJ orthodon- Manufactures and distributes Class II medical devices, tics, surgical orthodontics and breathing/sleep problem disposable supplies, reagents and accessories for in- Probetronix, LLC related orthodontics. vitro diagnostic use. Also, provides tools for hemostasis Colorado Springs monitoring and viscoelastic evaluations. www.probetronix.biz Samson Design Associates, Inc. Manufactures oscilloscope probes. Boulder Snoasis Medical www.samsondesign.com Denver Products Group International, Inc. Provides full service product development ranging www.snoasismedical.com Lyons from concept to production specifications, with many Develops dental regenerative products derived from www.productsgroup.com products for the medical field. discarded tissues and cells. Researches, develops and engineers ultrasound medical and veterinary equipment. Sandhill Scientific SomaLogic, Inc. Highlands Ranch Boulder Protomed, Inc. www.sandhillsci.com www.somalogic.com Westminster Designs, manufactures and distributes diagnostic Uses aptamer array technology and bioinformatics www.protomed.net products focused on gastroenterology. capabilities to discover disease-specific biomarkers Creates accurate anatomical models from CT scans and protein signatures. Develops medical diagnostics by using the latest imaging software and laser driven Science Care based on these signatures. technology. Aurora www.sciencecare.com Sonora Medical Systems, Inc. Prototype Casting, Inc. Provide human tissue for medical research and educa- Longmont Denver tion. We serve as a link between individual donors and www.4sonora.com www.protcast.com medical researchers and educators. Provides high quality products and services to the diag- Manufactures non-ferrous prototype parts for the medi- nostic ultrasound and MRI markets. ISO 9001 certified cal industry, specializes in RPM (Rubber Plaster Mold) Scientech, Inc. and FDA registered. casting, sand casting and rapid investment casting. Boulder www.scientech-inc.com Sontec Instruments, Inc PTA Corporation Manufactures analytical instruments: semi-micro bal- Centennial Longmont ances, analytical balances, semi-analytical balances, www.sontecinstruments.com www.ptacorp.com and toploading balances for the medical industry. Provides a broad line of instruments as well as custom Manufactures aluminum and steel molds for projects instrument manufacturing and in-house repair service. with lifetime runs of 5,000 to 250,000 pieces for medi- Scott Orthotic Labs, Inc. cal applications. Fort Collins Sophono, Inc. www.scottorthotic.com Boulder Quest Product Development Corporation Manufactures Orthotic and Prosthetic Components, www.sophono.com Wheat Ridge Pre-fabricated Orthotics, and Custom O&P Devices. Sophono, Inc. has developed the world’s first non-per- www.quest-corp.com cutaneous, implantable bone anchored hearing device. Helps bring to market medical products and analytical Securisyn Medical systems for small start-ups to research universities and Highlands Ranch Sorin Group international corporations. grants from NIH, DOD, www.securisyn.com Arvada NASA and NIST. Dedicated to a continuous process of increasing the www.sorin.com safety and effectiveness of our unique life-saving prod- Develops and produces cardiovascular and autologous Radiological Imaging Technology, Inc uct, which is utilized by skilled medical practitioners transfusion therapy products. Colorado Springs to deliver the highest quality emergency and intensive www.radimage.com care to their patients. Sound Surgical Technologies, LLC Provides clinical and research physicists with a high Louisville precision automated QA tool for advanced radiation Sealcon www.vaser.com therapies. Centennial Offers ultrasonic technologies and related techniques www.sealconusa.com for aesthetic surgery. Rand-Scot, Inc. Manufactures cable management components, includ- Fort Collins ing liquid tight strain relief fittings, flexible conduit, Sparton randscot.com M23 circular connectors and related products for the Frederick Designs and manufactures products for persons with health care industry. www.sparton.com disabilities including BBD Cushions and Mattress Leading contract manufacturer of low to medium vol- Overlays, EasyPivot Patient Lifts, and Saratoga Exer- Shape Ophthalmics LLC ume, complex products for the medical device, biotech cise Products. Aurora and industrial instrumentation markets. Develops state of the art devices and novel treatments Rapid Prototying Corporation for ophthalmic conditions through the application of Spectrum Laser & Technologies, Inc. Longmont advanced smart materials. Colorado Springs www.rapidpro.com www.spectrumlaser.com Offers engineering and design and other manufacturing Provides contract design and manufacturing services services for the medical device industry. for the medical industry.

BIOSCIENCE COLORADO 2012/2013 55 Medical Device and Related Companies

Spectranetics Corporation Swan Valley Medical, Inc. The Harloff Company Colorado Springs Aurora Colorado Springs www.spectranetics.com www.swanvalleymedical.com www.harloff.com Develops, manufactures, markets and distributes Developed a line of urology instruments that allow for Manufactures and sells a line of crash carts, medication single-use medical devices used in minimally invasive safer, faster, and more economical treatment of com- carts and other specialty carts for hospitals, nursing procedures within the cardiovascular system. mon urological disorders. homes, clinics and surgery centers.

ST Cardio Technologies, LLC Synergy Health Americas The Synaptic Corporation Denver Aurora Broomfield www.synergyhealthplc.com www.synapticusa.com www.stcardio.com Offers electron beam sterilization for medical and Develops Synaptic®, a patented pain control technol- Designs, develops, and manufactures electronic medi- pharmaceutical devices. ogy that works without drugs. Marketed in accordance cal devices for use in electrophysiology cardiac cath with FDA regulations for the treatment of acute and labs. Our Z6 Cardiac Stimulator is our first product and Synthes, Inc. chronic pain. has FDA 510(k) clearance. Monument www.synthes.com TheraTogs, Inc. St. Renatus, LLC Develops, produces and markets instruments, implants Telluride Fort Collins and biomaterials for the surgical fixation, correction and www.theratogs.com regeneration of the human skeleton and its soft tissues. www.st-renatus.com Produces an orthotic undergarment and strapping First needle-free, dental anesthetic suitable for use in system that gives clients with sensorimotor impairment TRS, Inc. a new modality for improving postural alignment and procedures involving most of the upper teeth. Uses an Boulder accurate and sophisticated method to anesthetize the www.oandp.com/products/trs stability. upper teeth without the risk and pain of a needle. Develops, manufactures, and markets body-powered prosthetic devices. Designs and builds technology for Tissue Genetics, Inc. StnDrd Infusion persons missing hands. Denver Parker www.tissuegenetics.com Molecular diagnostics company with unique technol- www.stndrdinfusion.com Tapeless Wound Care Products, LLC Englewood ogy for improving the care of patients with genetic Early-stage medical device company in the drug infusion diseases using biomarkers to identify patients with market with a standardized pump capable of performing www.tapelesswoundcare.com Manufactures and distributes a system of patented hereditary diseases and to determine the course of care. the product requirements currently met by syringe, cas- secondary wound dressing retention devices, offering sette, and ambulatory pump configurations. an alternative to traditional secondary wound dressings, TMJ Implants, Inc. for both human and animals. Golden StrionAir, Inc. www.tmj.com Louisville Tartan Orthopedics, Ltd Designs and manufactures alloplastic implants for the treat- www.strionair.com Northglenn ment of temporomandibular joint disorders and injuries. Manufactures and markets a product that uses dispos- www.tartanortho.com able media and that can be installed in any air handler Manufactures sacro lumbar belts, dorsal lumbar belts Toltec International, Inc. or HVAC system. (corsets and moldable inserts), Ottenberg style elbow Lakewood splint, pelvic traction belts, arm slings, cervical collars, www.toltec.biz acromioclavicular splints, and ankle supports. Stroke Recovery Systems, Inc. Toltec provides medical device engineering services Denver compliant with US FDA and international regulatory TDA Research, Inc. standards. We assist medical device companies with the www.strokeaid.com Wheat Ridge, Golden Develops the AutoMove AM800 that teaches healthy development and maintainence of medical devices in www.tda.com full compliance with the regulations and standards. parts of the brain after a stroke to take over lost func- Provides automated catalyst testing equipment to large tionality. chemical companies and national laboratories. Touch of Life Technologies, Inc. (ToLTech) Aurora Tech-X Corporation Summit Doppler Systems www.toltech.net Golden Boulder www.txcorp.com Develops procedural simulators in the areas of ortho- www.summitdoppler.com paedics, gastroenterology, rheumatology, radiology, Manufactures ultrasound Doppler systems used to Specializes in scientific and engineering software, including visualization and algorithm development. ophthalmology, and general surgical procedures. detect fetal heartbeat and to monitor peripheral arterial and venous blood flow. Tensegrity Prosthetics, Inc. Transtracheal Systems, Inc. Boulder Englewood Sunrise Medical Inc www.tensegrityprosthetics.com www.tto2.com Longmont Develops a prosthetic foot that mimics the functional Develops and manufactures innovative respiratory ther- www.sunrisemedical.com biomechanics of the human foot in walking. apy products that advance medical therapy for persons Provides home healthcare products including requiring continuous supplemental oxygen, including wheelchairs, respiratory, daily living aids, and speech Telsano Health the SCOOP transtracheal oxygen therapy system. augmentation devices. Aurora www.telsano.com Trelleborg Sealing Solutions Mountain Telsano manufactures both the preventive health moni- Broomfield Surefire Medical Inc. toring devices that gathers and analyzes our personal- www.trelleborg.com/en Boulder ized data but also provides the innovation to securely Supplies high-quality products and solutions for indus- www.surefiremedical.com display your data and trend charts anywhere anytime. trial sealing and bearing systems. Activities are focused The company is developing a novel infusion system for in many business areas including the food and pharma- the interventional radiology market. TeraBAT ceutical industries, as well as medical engineering. Longmont SurgiReal Products www.terabat.com Ultrathera Technologies, Inc. Fort Collins Developing a disruptive detection platform based on Colorado Springs www.surgireal.com terawaves technologies that will revolutionize disease www.ultrathera.com Creates and introduces innovative products and meth- diagnosis and patient care. Life sciences company dedicated to improving human ods for surgical training. performance by applying advanced technologies to TerumoBCT physiological and neurological needs. Maker of AeroS- Lakewood tim™ and PointScribe™. Supreme Cable Technologies, Inc. www.terumobct.com Thornton A global leader in blood component and cellular www.supremecable.com technologies, is the only company with the unique Value Plastics, Inc. Manufactures quality custom cable assemblies and combination of apheresis collections, manual and auto- Fort Collins wire harnesses. mated whole blood processing, and pathogen reduction www.valueplastics.com coupled with leading technologies in therapeutic Designs and manufactures plastic tubing fittings and connectors. COLORADO BIOSCIENCE ASSOCIATION MEMBER apheresis and cell processing. 56 2012/2013 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

ValveXchange, Inc. Amgen, Inc. Greenwood Village Biotechnology, Pharma and Related Companies Boulder/Longmont www.valvexchange.com www.amgen.com Develops a bioprosthetic heart valve with a percuta- Accera, Inc. Discovers, develops, manufactures and markets human neously-exchangeable leaflet set that provides lifetime Broomfield therapeutics based on advances in cellular and mo- service without anti-coagulation therapy. www.accerapharma.com lecular biology. Amgen’s operations in Colorado are Commercial-stage healthcare company focused on the dedicated to the mission of assuring patient supply and Vista LifeSciences discovery and development of pioneering therapeutics creating a world-class capability for rapid commercial- Parker to treat serious diseases. Accera has developed Axona, ization, launch and transfer of bulk biopharmaceutical www.vistalifesciences.com the first proprietary commercialized Alzheimer’s products. In addition to licensed manufacturing of Innovative Healthcare Technology Solutions for Global disease therapy that address the well recognized physi- EPOGEN, NPlate, XGEVA, Prolia and clinical thera- Healthcare Challenges ological hallmark and metabolic defect of hypome- peutics, Amgen Colorado pursues strategic contract tabolism, the brain’s inability to optimally metabolize manufacturing opportunities. WalkMed Infusion, LLC glucose. AmideBio, LLC Englewood Boulder www.walkmed.net ADA Technologies, Inc. Littleton www.amidebio.com Offers solutions for ambulatory infusion therapy and Focused on providing peptide and protein research pain management. www.adatech.com Specializes in the creation of high tech companies reagents and clinical products for a diverse array of based upon the development and commercialization of research and commercial targets using proprietary WAVi COMPANY Biopure-Process™ technology. Boulder innovative technologies. www.ewavi.com Ampio Pharmaceuticals, Inc. The platform is based on the Electroencephalograph Advanced Regenerative Therapies (ART) Denver (EEG) that integrates with physician diagnostic tools and Fort Collins ampiopharma.com a research library. Helps with interpretation and treat- www.art4dvm.com Develops innovative proprietary drugs for inflam- ment of brain ailments and performance including TBI, Provides a stem cell isolation and expansion service for mation, eye disease, kidney disease, CNS disease, PTSD, Alzheimer’s Age Management and depression. veterinary medicine. metabolic disease and male sexual dysfunction.

WestMed, Inc. Agilent Technologies Anabolic Laboratories Greenwood Village Boulder Colorado Springs www.westmedinc.com www.agilent.com www.anaboliclabs.com Designs, manufacturers and markets medical devices to Agilent Nucleic Acid Solutions develops and manu- Focused line of nutritional products, with state-of- anesthesia and respiratory professionals. factures therapeutic oligonucleotide in a multi-product, the-art pharmaceutical manufacturing facilities in 33,500 square foot facility. California and Colorado. Westone Laboratories Colorado Springs Agripro COKER Animal Health Options www.westone.com Berthoud Golden Designs and manufactures custom earmolds for hear- www.agriprowheat.com www.animalhealthoptions.com ing healthcare and other applications. Develops and delivers superior wheat seed genetics in Animal Health Options has been offering high quality North America. antioxidants and nutritional supplements that meet or exceed industry standards and provide a noticeable Wi LLC – Medical Device Product Development benefit to dogs, cats and horses. Englewood AKTIV-DRY www.wiinc.net Boulder www.aktiv-dry.com ApopLogic Pharmaceuticals, LLC Designs and engineers medical devices. Including inno- Aurora vative services such as laser welding, assay design, and Provides dry powder processing solutions for the vaccine, pharmaceutical, and biotechnology industries. www.apoplogic.com air bubble management. Focused on the development and commercialization of Breceptin, a unique oncolytic drug for the treatment of Ximedix, Inc. Albany Molecular Research, Inc (AMRI) a wide range of solid tumors. Colorado Springs Denver www.ximedix.com www.amriglobal.com Aquatic BioSystems Manufactures and sells single patient use medical Performs services including drug discovery, pharma- Fort Collins products for the anesthesia, respiratory care, critical ceutical development, and manufacturing of active www.aquaticbiosystems.com care and emergency medicine applications. ingredients and pharmaceutical intermediates for many Full-service organism culturing facility specializing of the world’s leading healthcare companies. in the production and distribution of freshwater and Xntera marine organisms for aquatic toxicology, biomonitoring Aurora Allergan, Inc. and other research activities. Medical Devices will produce initially premium medi- Denver cal syringes for dental market with the strategic product www.allergan.com ARCA biopharma, Inc. benefits of automatic safety, ease of use, and comfort Multi-specialty health care company focused on Broomfield, Aurora for the patient. Later on products will be developed discovering, developing and commercializing innova- www.arcabiopharma.com to meet the demands in other medical fields such as tive pharmaceuticals, biologics, medical devices and Specializes in developing and commercializing psychiatric, nuclear and diabetes. over-the-counter consumer products genetically-targeted therapies for heart failure and other cardiovascular diseases. Yamato Corporation Allos Therapeutics, Inc. Colorado Springs Westminster Ariel Pharmaceuticals www.yamatocorp.com www.allos.com Broomfield Manufactures and sells weighing equipment and sys- Develops and commercializes small molecule thera- www.arielpharma.com tems for medical facilities. peutics for the treatment of cancer. Ariel Pharmaceuticals is a clinical-stage specialty pharmaceutical company focused on acute neurology. Lead product, AP-1531, is an EP4 receptor antagonist in Zetek, Inc. Alpharma, Inc. Longmont Phase II for acute migraine. Tamiasyn is a proprietary Aurora IV product in Phase I for hemorrhagic shock. Both www.zetek.net www.alpharma.com Alpharma’s field-proven feed additives and water products target major unmet medical needs where there Manufactures the OvaCue family of ovulation predic- is little competition. tion products. solubles help prevent or treat common deficiencies and diseases in cattle, swine, and poultry that may Array BioPharma negatively affect their health. Zynex Medical, Inc. Boulder, Longmont Lone Tree www.arraybiopharma.com www.zynexmed.com American Allied Biochemical, Inc. Discovers, develops and commercializes targeted small Offers electrotherapy products, utilizing various meth- Aurora molecule drugs to treat debilitating and life-threatening ods of non-invasive muscle stimulation and electromy- www.aablabs.com diseases such as cancer. ography technology, Interferential Current (IFC) and Specializes in the purification and distribution of Transcutaneous Electrical Nerve Stimulation (TENS). restriction endonucleases enzymes.

BIOSCIENCE COLORADO 2012/2013 57 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

ASDx Biosystems, Inc. Boulder Scientific Company CHATA Biosystems Boulder Mead Fort Collins www.asdxbio.com www.bouldersci.com www.chatasolutions.com Specializes in the development of immunoassays for Provides organometallic compounds to the pharma- Manufactures blended reagents, HPLC mobile phases, environmental agents, foodborne pathogens, infectious ceutical, polymer, and specialty chemical industries. standards, buffers and dissolution media. diseases and oncology biomarkers using luminescence detection technologies and dedicated luminometer Brotica CHD Bioscience, Inc. instrument systems. Bellvue Fort Collins www.interval33.com www.chdbioscience.com AspenBio Pharma, Inc. Produces Interval33, a termite attractant which works Devlopeing a biocide which is a derivative of a natural Castle Rock by producing the precise level of CO2 that has been molecule, is environmentally friendly (“green”) and www.aspenbioinc.com shown to attract termites, all natural and ani mal safe. which has shown to be extremely efficacious against a Primarily focused on advancing towards commer- broad range of pathogens including the difficult to kill cialization, our recently patented blood-based human Cargill Research MRSA and c-difficile microbes that are the source of diagnostic test, AppyScore™ to aid in the diagnosis Fort Collins secondary infections in hospitals and other healthcare of human appendicitis and several novel reproduction www.cargill.com facilities. drugs for use in high value animals. Develops, processes and markets science-based, health promoting ingredients for food and dietary Chemizon Inc. Astellas Pharma US, Inc. supplement industries worldwide. Longmont Denver www.chemizon.com www.astellas.us Catalent Pharma Solutions, Inc. Focused on the discovery and development of targeted Researches and develops pharmaceuticals for select Boulder therapies to treat patients afflicted with cancer, inflam- theraputic areas, including Urology, Immunology, www.catalent.com matory and metabolic diseases. Dermatology, Cardiology, and Infectious Diseases. Designs, manufactures and distributes specialized medical products for fluid management of pleural ClinImmune Labs Aurogen effusion and ascites. Aurora Fort Collins www.clinimmune.com www.aurogen.com Caveo Therapeutics Provides genetic testing for transplant patients in addi- Produces a pharmaceutical treatment for diabetic Aurora tion to stem cell processing and umbilical cord blood neuropathy, with a second invention showing that www.caveotherapeutics.com banking. neurotrophic hormones can act across the blood-brain Discovers and develops innovative biopharma- barrier (BBB) to treat various brain disorders. ceuticals to treat and cure hematologic conditions. Clovis Oncology, Inc. Provides two research reagents, highly specific mono- Boulder Avidity, LLC clonal antibodies to the Mer receptor tyrosine kinase www.clovisoncology.com Aurora Focused on acquiring, developing and commercializing www.avidity.com CBL (Chemical and Biopharmaceutical Labora- innovative anti-cancer agents in the US, Europe and Licenses the patented biotin-accepting peptides (Avi- tories) additional international markets. Tag) technology which exploits the tight interaction Boulder of avidin or streptavidin with biotin for immobilizing, www.cblbiopharma.com Colorado Biolabs, Inc. purifying and visualizing proteins. Offering peptide starting materials, peptide in- Frederick termediates, and industrial and commercial-scale www.proferrin.com BaroFold, Inc. manufacturing of proprietary and generic GMP and Colorado Biolabs, Inc., the manufacturer of Proferrin® Aurora/ Boulder non-GMP peptides. ES and Proferrin® Forte, was founded in 1997 with a www.barofold.com plan to develop and market Proferrin – an oral iron sup- BaroFold applies its Pressure Enabled Protein Manu- Cedarburg Hauser plement made from heme iron polypeptide (HIP). Our facturing (PreEMT™) technology to improve the Denver proprietary process results in an oral iron product that tolerability, efficacy and safety of a wide variety of www.cedarburghauser.com provides an optimal amount of HIP in a single tablet. protein therapeutics for bio-pharmaceutical compa- Full service API manufacturer of GMP materials that nies, research institutions, and government agencies. include small molecule API’s, adjuvants, conjugates Colorado Genetics, Inc. PreEMT employs high pressure to disaggregate and and toll manufacturing substances. Loveland refold proteins, which may have a significant impact on www.coloradogenetics.com the quality of these biotherapeutics by improving their Provides livestock embryo-transfer research, artificial activity, homogeneity and safety. Contract Synthesis & insemination, embryo collection, freezing and transfer, GMP Manufacturing and international import and export services. BioResponse, LLC D g Boulder Colorado Histo-Prep (CH-P) www.bioresponse.com e Fort Collins Researches, develops and commercializes dietary www.histoprep.com supplements for better absorption and functional foods. n t Produces high quality slides, clinical chemistry and v o hematology data and fully integrated and detailed BioServe Space Technologies seamless pathology reports. Boulder e www.colorado.edu/engineering/BioServe r Kg Colorado Serum Company Researches space life science with a wide range of bio- Denver technology applications involving animals, plants and 720.406.4700 www.colorado-serum.com microorganisms. Specializing in conducting micrograv- Supplies veterinary biologic vaccines, instruments, ity life science research and designing and developing www.cedarburghauser.com laboratory reagents and serums for the veterinary space flight hardware. industry. Cell>Point Biosyntrx Inc. Centennial Corden Pharma Colorado Springs www.cellpointweb.com Boulder www.biosyntrx.com Develops novel radiopharmaceutical imaging agents, www.cordenpharmacolorado.com Develops nutraceuticals to address the micronutrient radiotherapeutic agents and local regional radio/ Corden Pharma Colorado is the small to large-scale needs of the dry eye, cataract, macular degeneration, chemotherapeutic drug delivery systems for the resource for peptides manufacturing. glaucoma and diabetic retinopathy patient. diagnosis, treatment and post therapy asessment of cancer, cardiovascular disease, infectious disease and Crestone, Inc. Bolder BioTechnology, Inc. metabolic diseases. Boulder Boulder www.crestonepharma.com www.bolderbio.com Cévan International, Inc. Drug discovery and development company focused Uses advanced protein engineering technologies to Longmont on developing novel treatments for serious bacterial create proprietary human protein pharmaceuticals with www.cevan.com infections. The company currently has two advanced enhanced therapeutic properties. Delivers vitamins, minerals and botanical extracts pre-clinical programs that address areas of significant as well as specialty nutriceutical formulations and and growing unmet medical need, both with novel COLORADO BIOSCIENCE ASSOCIATION MEMBER antioxidants. mechanism of action agents.

58 2012/2013 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

Cytoskeleton, Inc. GeneThera, Inc. HepQuant, LLC Denver Westminster Aurora www.cytoskeleton.com www.genethera.net www.hepquant.com Offers kits for drug screening, signal transduction and Develops and markets the latest molecular technologies Designed test parameters using continuous variables cytoskeletal research specializing in the production to eradicate “cross over” diseases such as Johne’s Dis- that may be correlated to clinical features or may be of purified proteins and easy-to-use kits to study bio- ease, Mad Cow Disease, Chronic Wasting Disease, and followed over time to measure disease progression. chemical and cellular processes. E.coli. Develops assay tests and vaccines to radicate the HepQuant-E is non-invasive, uses stable (not radioac- threat to humans of diseases transmitted up the food tive) isotopes, and relies on natural, well-defined DaVita Clinical Research (DCR) chain by cattle, elk and deer. hepatic functions to measure the portal circulation. Denver Genetic Technologies Limited Heska Corporation www.davitaclinicalresearch.com Fort Collins Loveland Offers a complete array of early-phase study www.gtglabs.com www.heska.com capabilities through its two state-of-the-art research Uses the latest technology to identify changes in DNA Develops advanced diagnostics and specialty products facilities. to either confirm a diagnosis of a specific disorder of for veterinary practices that focus on companion which a person displays signs or symptoms, or to iden- animals. Efficas, Inc. tify individuals at risk of developing a disease before Boulder any symptoms appear. Hiberna Corporation www.efficas.com Boulder Develops bioactive products that offer natural relief Gonex Inc. www.hibernapharma.com from asthma and allergies in both humans and animals. Fort Collins Pursuing the potential clinical application of hiberna- www.cedusinc.com tion in order to slow metabolism thereby extending ELISA Tech Dedicated to the research, development and commer- survival limits in traumas that reduce oxygen to certain Aurora cialization of hormonal based health care strategies cells, e.g. in the heart and brain. www.elisatech.com for both the human and companion animal markets Provides immunoassays for the measurement of cyto- including technology for sterilizing companion animals Hospira, Inc. kines, growth factors, and lipid inflammatory mediators with a single injection. Boulder such as prostaglandins and leukotrienes www.hospira.com GlaxoSmithKline Supplies injectably generic and specialty pharmaceu- Evolutionary Genomics (EG) Denver ticals. The Colorado site specializes in the supply of Lafayette www.gsk.com active pharmaceutical ingredients for both internal and www.evolgen.com Produces medicines that treat six major disease areas external markets. Identifies genes with a high likelihood of commercial – asthma, virus control, infections, mental health, value for downstream validation through their propri- diabetes and digestive conditions as well as vaccines iCanDxRx etary Adapted Traits platform. and new treatments for cancer. Aurora Developing small molecules that stimulate the number Gliacor Therapeutics LLC Flagship Biosciences and function of white blood cells. Westminster Fort Collins Characterize the efficacy and safety of a novel series www.flagshipbio.com ICVrx Oncology drug development and tissue analytics and of antiinflammatory compounds to test their suitability Aurora pathology services. as a new treatment for blocking the progression of Parkinson’s. www.icvrx.com Drug reformulations and delivery systems targeting FluTrends International, LLC disorders of the central nervous system. Denver/Aurora GlobeImmune, Inc. Louisville www.flutrends.com IHCtech, LLC Biotechnology company that plans to develop and com- www.globeimmune.com Aurora mercialize products for the prevention of influenza. Discovers, develops and manufactures potent, targeted molecular immunotherapies called Tarmogens, targeted www.ihctech.net Offers custom histopathology services, antibodies, GEL Analytics, LLC antigens that distinguish diseased cells from normal cells, for the treatment of cancer and infectious diseases. probes and biosensors tested in tissue. Specializes in Golden immunohistochemistry and in situ hybridization. www.gel.com Offers expertise in the field of mass spectrometry and Great Lakes Pharmaceuticals imuTek Laboratories, Inc. provides chemistry, radiochemistry, radiobioassay and Denver Fort Collins bioanalytical analysis. www.glpharma.com Development leading to commercialization of innova- www.imutek.com Develops and markets bovine colostrums for the nutri- Gene Check, Inc. tive, effective product for prevention of catheter related microbial infections in clinical and in outpatient settings tion and health products industry. The first manufac- Greeley turer to receive an indication for colostrum for the www.genecheck.com Greffex, Inc./ Isogenis, Inc. passive transfer of antibodies (immunoglobulins) in dry Gene Check is a diagnostic laboratory specializing in powder form. veterinary genetics. In addition, Gene Check maintains Aurora a dynamic biotech research program, including rare www.greffex.com Institute for Therapeutic Biology DNA sequence and SNP detection. Develops and produces new therapeutics for immune suppression in humans to prevent transplant rejection, Denver www.therapeuticbiology.org Genentech improve gene therapy and develop novel approaches to the treatment of autoimmune diseases. Research organization studying the Role of T-Cell Denver maturation in Immunology. www.gene.com Using human genetic information to discover, develop, Hauser Laboratories, Division of Microbac InViragen, Inc. manufacture and commercialize medicines to treat pa- Boulder Fort Collins tients with serious or life-threatening medical conditions. www.hauserlabs.com Provides research, development, and testing to the www.inviragen.com pharmaceutical, natural products, dietary supplement, Focused on developing life-saving vaccines to protect Genesis Laboratories, Inc. and medical device industries. against emerging infectious diseases worldwide. Wellington Inviragen’s lead product is a vaccine to protect against www.genesislabs.com dengue fever. Provides services to clients in the agrochemical and HemoGenix pharmaceutical industries, rodenticide research and Colorado Springs iPDx Biosciences, Inc. development, as well as invasive species, zoonotic www.hemogenix.com Private contract research service and assay develop- Boulder disease, and conservation research. ment laboratory specializing in developing predictive www.ipdxbio.com in vitro assay platforms for primary human and animal Develops and markets multiplexed immunoassay target cells and stem cell hemotoxicity testing. and proteomic test systems and applications for the decentralized and point-of-care personalized diagnostic market. Clinical applications will focus on autoimmune, metabolic, oncology and neurodegenerative disorders.

BIOSCIENCE COLORADO 2012/2013 59 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

Johnson & Johnson MacLeod Pharmaceuticals, Inc. N30 Pharmaceuticals, LLC Denver Fort Collins Boulder www.jnj.com www.macleodpharma.com www.n30pharma.com Manufactures a broad selection of health care prod- Develops and manufactures anti-bacterial pharmaceuti- Drugs target nitric oxide reductase (NOR), the most ucts, as well as a provider of related services, for the cals for the veterinary industry. important of which is s-nitrosoglutathione reductase consumer, pharmaceutical, and medical devices and (GSNOR) an enzyme of central importance in human diagnostics markets. Martek Biosciences Corporation health and disease. Boulder Keen Ingredients, Inc. www.martek.com NanoTrans Technologies Louisville Develops, manufactures and sells products from mi- Aurora www.keeningredients.com croalgae. Products include nutritional supplements and Early-stage company focused on developing a novel Develops process to de-bitter and stabilize quinoa natu- food ingredients which play a role in promoting mental ophthalmic drug delivery platform that will topically and cardiovascular health. rally. Supplying the natural and gluten free industries deliver drug therapies to both the front and back of the with high quality Quinoa ingredients. eye. This system provides for enhanced uptake, greater MBC Pharma, Inc. penetration and sustained drug release into ocular Aurora Keeton Industries, Inc. tissue. Wellington www.mbcpharma.com Biopharmaceutical company focused on discovering www.keetonaqua.com Nex Step, Inc. Researches and develops biological water treatment, and developing drugs for bone diseases such as cancer and osteoporosis. Lakewood aeration, ozone aeration, solids removal, biofiltration www.nexstepcorp.com and other new technologies. MedImmune, LLC Pharmacogenomic Decision Support Solutions. Kimball Genetics, Inc. Denver www.medimmune.com Novartis Pharmaceuticals Corporation Denver Strives to provide better medicines to patients, new Broomfield www.kimballgenetics.com medical options for physicians, and rewarding careers www.novartis.com Genetic testing laboratory specializing in DNA analysis to employees. Researches and develops products to protect and for common genetic disorders that are preventable or improve health and well-being with core businesses in can be treated. Mediral International, Inc. pharmaceuticals, vaccines, consumer health, generics, Denver eye care and animal health. KromaTid, Inc. www.mediral.com Fort Collins Develops, manufactures and sells homeopathic phar- Novus Biologicals, Inc. www.kromatid.com maceuticals taking into consideration antidotes. Littleton Develops a method and kit using chromatid paints to www.novusbio.com improve detection of chromosomal inversions. The MenoGeniX Develops, tests and markets antibodies for research improvement is important to medical applications such Aurora of human diseases such as cancer, cardiovascular and as cancer and birth defects. www.menogenix.com neurological disorders. Clinical stage biotechnology company focused on the LABS, Inc. development of an approved drug, in a new indication, Nutraceutix, Inc. Denver menopause, and the menopause-like symptoms that Lafayette www.labs-inc.org occur in certain breast and prostate cancer patients. www.nutraceutix.net Provides laboratory testing services focused on donor Offers probiotic organisms (powders) and finished probi- eligibiligy determination and final product safety; Merck & Co., Inc. otic supplements. Specializes in custom crafting dietary infectious disease, microbiology, histocompatibility Denver supplements with advanced delivery technologies. and environmental monitoring. www.merck.com Merck and Co. produces products that cover a broad Legacy BioDesign, LLC Oberon FMR range of areas, including heart and respiratory health, Aurora Johnstown infectious diseases, sun care and women’s health. And www.LegacyBioDesign.com www.oberonfmr.com they focus their research on conditions that affect Early stage company with proprietary technology Conducts peptide and protein formulation and assay millions of people around the world – diseases like development work for biopharma companies. The capable of producing a cost-effective, sustainably Alzheimer’s, diabetes and cancer – while building produced protein meal. Oberon’s product serves as company also specializes in drug delivery and process strengths in new areas like biologics. development of biotechnology-based products. a fish meal replacement (FMR) or additive ingredi- ent for animal feeds, primarily those destined for the miRagen Therapeutics aquaculture industry. Life BioScience Inc. Boulder Longmont/ Aurora www.miragentherapeutics.com www.lifebioscience.com Improves patients’ lives by developing innovative mi- Omni Bio Pharmaceutical, Inc. Developed a patent pending glass-ceramic material that croRNA (miRNA) based therapeutics for the treatment Greenwood Village is photo-structurable. We fabricate 3D glass and ce- of cardiovascular and muscle disease. miRNAs, are a www.omnibiopharma.com ramic micro-arrays for protein, DNA, glycan, peptides recently discovered class of small RNAs encoded in the Advancing broad-spectrum therapeutics targeting and carbohydrates. We also produce and sell printed genome, are short, single-stranded RNA molecules. bacterial and viral diseases, biohazards, diabetes and microarrays. Out other products revolve around cell transplant rejection. based assay and multiplexed micro sphere platforms Molecular BioSciences, Inc. utilizing our glass-ceramic material. Boulder OncoTherix www.molbio.com Aurora LifeTime Pharmaceuticals Manufactures products such as water soluble biotinyl- www.oncotherix.com Aurora ation reagents, vitamin derivatives, crosslinking re- Clinical stage oncology company focused on the Developing several classes of small molecules that agents, lipophilic probes, fluorophores, radioiodination development of InCell-RT (Intracellular radiotherapy) stimulate production and function of WBCs. reagents, and dendritic cores for preparing oligomers. for the treatment of locally-advanced cancers (LACs). InCell-RT is a unique, DNA-ligated, nanometer-scale Light Labs Monsanto Company intracellular radiotherapy with the potential to selec- Aurora Englewood tively kill cancer cells without causing damage to sur- www.lightlabsusa.com www.monsanto.com rounding healthy tissue and without the development of Light Labs distributes, PCR tubes, TPP tissue culture, Leading global provider of technology-based solutions treatment resistance. pipette tips, microcentrifuge tubes, barrier tips, latex and agricultural products that improve farm productiv- gloves, PCR supplies, and much more. ity and food quality. Monsanto remains focused on OnKure, Inc. enabling both small-holder and large-scale farmers to Longmont Lohocla Research Corporation produce more from their land while conserving more of Exploring a highly potent and selective HDAC inhibi- Aurora our world’s natural resources such as water and energy. tor as an anti-tumor drug. www.lohocla.com Develops diagnostics and therapeutics focused on pain, Mosaic Biosciences psychiatric and addictive disorders such as alcoholism, Denver/Aurora depression, smoking cessation and chronic pain. mosaicbio.com Start-up company focused on the development of in- COLORADO BIOSCIENCE ASSOCIATION MEMBER novative materials for tissue regeneration and repair.

60 2012/2013 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

OPX Bioechnologies Roche Custom Biotech SuviCa, Inc. Boulder Indianapolis, IN Boulder www.opxbiotechnologies.com www.roche-applied-science.com www.suvica.com Technology platform enables rapid, rational, and Customize and supply reagents, products and services, Discovery and development of small molecules for the robust optimization of microbes and bioprocesses to customized to the quality and regulatory needs of the treatment of cancer. manufacture bioproducts with equivalent performance customer. and improved sustainability at lower cost compared to Taiga Biotechnologies, Inc. petroleum-based alternatives. Rocky Mountain Biosystems, Inc. Aurora Wheat Ridge www.taigabiotech.com Pambec Laboratories, Inc. Develops cellular, biologic and small molecule ap- Loveland Research and development of transdermal pharma- Researches drug discoveries in the field of AIDS. ceuticals and delivery systems, cosmetic devices, and proaches to treat hematological diseases, including can- tissue adhesives. cers, immunodeficiencies and autoimmune conditions. Peak Analytical, Inc. Golden Thermo Fisher Scientific www.peaklab.net Rocky Mountain Diagnostics, Inc. Lafayette Specializes in materials and chemical analysis. Per- Colorado Springs www.thermofisher.com forms a variety of molecular and atomic level spectro- www.rmdiagnostics.com Scientific leadership and innovation in RNAi, Gene scopic techniques to identify failures and defects. Provides immunodiagnostic assays and reagents for Expression, qPCR/PCR Detection, and Molecular biogenic amines, research reagents, a CLIA certi- Biology technologies come together with the Thermo PeptiVir fied reference laboratory and contract manufacturing Scientific Dharmacon, Open Biosystems, ABgene, Aurora services. Finnzymes, and Fermentas product lines to provide peptivir.com world-leading solutions for gene analysis. PeptiVir is an early stage biopharmaceutical company Rocky Mountain Instrumental Laboratories focused on the development and commercialization of Fort Collins a conformationally-constrained, synthetic peptide- TOLMAR, Inc. www.rockylab.com Fort Collins based vaccine platform for the prevention of viral Provides contract chromatographic and mass spectro- diseases. www.tolmar.com metric analysis of pharmaceuticals (both traditional Develops and manufacturers both proprietary and drugs and biotechnology products, such as proteins and generic pharmaceutical products with specific focus in Pfizer Pharmaceutical Company peptides and oligonucleotides), veterinary and human therapeutic areas of dental, dermatology, and oncology. Centennial endocrinology, and forensic toxicology. www.pfizer.com Discovers, develops, manufactures, and markets pre- Rocky Mountain Reagents, Inc. Upsher-Smith Laboratoriess, Inc. scription medicines for humans and animals. Golden Denver www.rmreagents.com www.upsher-smith.com PhosphoSolutions, LLC Develops, manufactures and markets a vast range of Aurora Manufactures stains, culture media and chemistry solutions for the medical industry, as well as titration prescription and over-the-counter products for cardiol- www.phosphosolutions.com ogy, dermatology, women’s health and other areas. Designs and produces phosphoproteins solutions using reagents, indicators, acids, bases, and a variety of phosphor-specific antibodies. Phosphoproteins are chemicals for industrial uses. thought to be critical elements in neurological diseases Ventria Bioscience such as Alzheimer’s and in cancer. RST Bioscience LLC Fort Collins Aurora www.ventria.com Pisces Molecular Develop and commercialize assay system to monitor Develops a protein expression technology platform Boulder astronauts for viral infection during space flight. called ExpressTec with a product pipeline in human www.pisces-molecular.com nutrition and therapeutics. Applies molecular biology to problems in the aquatic Saigene Biotech Inc. environment. Denver Ventrus Biosciences, Inc. www.saigene.com Greenwood Village Plura Biosciences Inc Developing testing processes to identify harmful algae www.ventrusbio.com Lafayette blooms. A specialty pharmaceutical company focused on the www.plurabioscience.com late-stage development and commercialization of Specialized catalysts and chemicals that enable highly Sandoz gastroenterology products. efficient, cost effective and green chemistry solutions Broomfield in the manufacture of important life science products. www.us.sandoz.com Verdant BioSciences Corporation Focuses on pharmaceuticals, consumer health, gener- Denver Qgenta ics, eye care and animal health. Therapeutic categories Aurora www.verdantbio.com inlcude anti-infectives, anti-arthritics, cardiovasculars, Develops plant biochemical regulators that provide Harnessing innovative chemistry and biology in the gastrointestinal agents & psychotherapeutics. development of molecular targeted agents for the treat- superior plant performance and unlock the produc- ment of cancer. tive power of plants in markets from floriculture to Siva Therapeutics Inc industrial agriculture. Boulder Quark Pharmaceuticals, Inc. www.sivatherapeutics.com Boulder Commercialize a proprietary therapeutic device tech- VetDC www.quarkpharma.com nology, based on gold nanorods, that can be used both Fort Collins Discovers and develops siRNA drug candidates for www.vet-dc.com treating Age-related Macular Degeneration and preven- independently, and also in conjunction with existing and new cancer drugs. Focused on development of novel devices, diagnostics tion of Acute Renal Failure. and therapeutics for emerging veterinary markets. Reckitt Benckiser (RB) STA Laboratories, Inc. Fort Collins Longmont www.rb.com www.stalabs.com Fastest-growing companies in household, health and Agricultural product testing laboratory that offers seed personal care products. quality, genomics, plant health and diagnostic services and products. Regenerative Sciences Inc. Broomfield Summit Plant Laboratories, Inc. www.regenexx.com Fort Collins Advances stem cell therapies through development www.plantlabs.com of Regenexx™, an injection procedure to treat a wide Applies laboratory plant cloning and greenhouse variety of painful conditions. technologies to produce planting stocks for breeders, greenhouses, and field crop producers.

BIOSCIENCE COLORADO 2012/2013 61 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES/BioFuels and Related Companies

Vitro Diagnostics, Inc. Blue Sun Biodiesel Golden BioFuels and Related Companies Golden www.vitrodiag.com www.gobluesun.com Develops and commercializes products derived from A1 Organics Distributes premium agricultural and renewable fuel human cell line research with a focus predominantly Eaton products. Blue Sun Fusion™ a blend of premium Blue in stem cell R&D related to numerous diseases such www.a1organics.com Sun Biodiesel (20%) with petroleum diesel fuel (80%), as heart disease, stroke, Parkinson’s and Alzheimer’s Composts and recycles organic by-products from vari- along with proprietary additive package specifically disease. ous waste: yard trimmings, wood, biocides, agricultural tailored for regional climates and seasons, is available by-products, manure, brewery by-products, construc- at numerous retail pumps throughout Colorado, Wyo- Vitrolife, Inc. tion debris and food residuals. ming, New Mexico, Nebraska, Utah, and Idaho. Englewood www.vitrolife.com A2BE Carbon Capture, LLC Carbo Analytics, LLC. Develops, manufactures and sells products and systems Boulder Fort Collins for the preparation, cultivation and storage of human www.algaeatwork.com www.carboanalytics.com cells, tissue and organs. Product areas include fertility, developing bio-secure, scalable, climate adaptive, and Commercial development of an online sugar monitor transplantation and stem cell cultivation. highly cost effective technology for producing valuable with immediate application for more cost effective fuel and food from CO2 using algal photosynthesis and biofuels production. Vitro Biopharma bio-harvesting. Golden www.vitrobiopharma.com Aerophase, Inc. Colorado Center for Biorefining and Owns US patents for production of FSH, immortaliza- Longmont tion of pituitary cells, and a cell line that produces Biofuels (C2B2) www.aerophase.com Boulder beta islets for use in treatment of diabetes. Vitro also Research and Development of technologies that reduce www.c2b2web.org owns a pending international patent for generation of environmental impact, and efficient extraction system pluripotent stem cells. A cooperative research and educational center devoted for biodiesel to the conversion of biomass to fuels and other products. Works to establish ground-breaking research and VRL Laboratories BBI International Centennial educational programs for the advancement of renew- Lakewood able energy technologies. www.vrl.net www.bbibiofuels.com Laboratory offers full service regulated donor eligibil- Offers consulting services, including feasibility studies, Ciris Energy, Inc. ity testing for the human cell and tissue community. market analyses, site & resource assessments, econom- Centennial ic impact studies, business plans, industry benchmark- www.cirisenergy.com Vivaldi Biosciences ing and industry surveys to the biofuels sector. Fort Collins Start-up company developing a unique biotechnology www.vivaldibiosciences.com for the conversion of fossil sources of carbon such as The Biocer Group of Companies low rank coals to natural gas and valuable chemicals. Developing advanced vaccines for prevention of com- Englewood mon seasonal influenza and emergent pandemic flu. www.biocer.net Community Power Corporation Emerging group of companies in Agriculture, Forestry, Littleton Warren Analytical Laboratory and Biotechnology space. Greeley www.gocpc.com Develops, commercializes and markets modular bio- www.warrenlab.com BioEnergy of Colorado, LLC Specializes in food microbiology, molecular biology, power systems to meet the needs of distributed energy Denver food chemistry, residue chemistry and nutritional consumers in both developing and developed countries. labeling. www.bioenergycolorado.com Produces biofuel alternatives utilizing Soy Biodiesel Front Range Energy, LLC from virgin soy oil. Current product line includes Western States Biopharmaceuticals, Inc. Windsor Biodiesel (Gold and Green™) and BioHeat. Aurora www.frontrangeenergy.com www.westernstatesbiopharm.com Ethanol producer since 2006. Will process approx. Novel anti-inflammatory therapeutics for autoimmune BioFuel Energy Corporation 40 million gallons of ethanol and 396,000 tons of wet diseases Denver distillers’ grain annually. www.bfenergy.com Constructs large scale ethanol production facilities in Wildlife Pharmaceuticals, Inc. GeoSynFuels, LLC cooperation with Cargill and owns and operates two Fort Collins Golden of the largest dry mill ethanol facilities in the United www.wildpharm.com www.geosynfuels.com Providing pharmaceuticals for the safe and humane States. Develops a low-cost method to convert cellulosic care of non-domestic and exotic wildlife species. biomass into fuel. The technology uses biological BioLynceus Biological Solutions mechanisms set in a solid-state fermenter (“SSF”) to YewSavin, Inc. Estes Park convert the biomass into ethanol and/or methane. Fort Collins www.biolynceusturf.com Working to help local governments, businesses and citi- www.ajorganica.com Gevo, Inc. zens to use environmentally safe alternatives to harsh Develops chemical and biochemical technologies. Suc- Englewood toxic chemicals. Our Biological Solutions renew the cessfully finished multi-step syntheses using Bromina- www.gevo.com tion, Grignard reaction, Suzuki coupling, Amidation, natural ecological system with biologically sound prod- Develops advanced biofuels like isobutanol, butanol and Esterification reactions. ucts that do not contaminate soil or water resources. that will provide a sustainable path to the replacement of petrochemicals like gasoline, diesel and jet fuel. ZeoponiX, Inc. Biomass Energy Foundation (BEF) Boulder Franktown Intermountain CHP Center www.zeoponix.com www.woodgas.com Boulder Researches alternative fuels such as dried fruit pits, Develops NASA originated technology to produce www.intermountainCHP.org a soil amendment/fertilizer zeoponic material that vegetable oil, wood, coffee grounds and the methods to Formed by the U.S. Department of Energy to increase utilizes nutrients more efficiently and reduces nutrient produce biofuels. adoption of Combined heat and power (CHP) in the leaching into the environment. states of Arizona, Colorado, New Mexico, Utah, and BioVantage Resources, Inc. Wyoming. ZooPharm, Inc. Golden Fort Collins www.biovantageresources.com LUCA Technologies, Inc. Delivers algae-based bioremediation solutions for mu- www.zoopharm.net Golden nicipal, industrial and agricultural wastewater treatment. Specialized veterinary compounding pharmacy. We www.lucatechnologies.com custom compound analgesics, sedatives, their antago- Researches the ability of naturally occurring micro- nists, and other unique drugs for use in veterinary organisms to convert under-utilized domestic oil, medicine. organic-rich shale and coal resources to clean, renewable energy.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

62 2012/2013 BIOSCIENCE COLORADO Research and Education Institutions

Novo Energy LLC Children’s Hospital Colorado Fort Collins Research and Education Institutions Aurora www.novoenergyllc.com www.childrenscolorado.org Colorado-based renewable energy company that Advanced Diagnostic Laboratories (Adx) at Children’s Hospital Colorado has been ranked for more provides state-of-the-art technology, equipment, and National Jewish Health than a decade as one of the best children’s hospitals project support services for the renewable energy and Denver nationally in U.S. News & World Report, and as the solid waste disposal industries. www.njlabs.org consistent choice eight years in a row by area physi- National Jewish Health is known worldwide for treat- cians for the care of their loved ones. Founded in 1908, Nuemann Systems Group ment of patients with respiratory, cardiac, immune Children’s Colorado is a private, not-for-profit pediatric Colorado Springs and related disorders, and for groundbreaking medical health-care network dedicated 100 percent to caring www.neumannsystemsgroup.com research. The Advanced Diagnostic Laboratories for kids. With 1,130 pediatric specialists and more Research, technology and product development focused provide innovative services within the extraordinary than 2,300 full-time employees, Children’s Colorado on product prototyping of gas-liquid contactor systems clinical and research environment of National Jewish is home to a number of nationally and internationally for chemical processing and emissions control. Health. Leveraging our expertise in both laboratory recognized medical programs. medicine and personalized medicine, we offer an ever- PolyNEW, Inc. expanding menu of diagnostic tests, as well as contract Golden/Aurora Colorado Center for Drug Discovery (C2D2) www.polynewinc.com research services. Our laboratories are CAP and CLIA Fort Collins Developed a new class of PLA bioplastics which it certified, and have earned the prestigious CAP 15189℠ c2d2.org terms “ecobionanocomposites.” These are nanocom- accreditation. A non-profit organization funded through the State of posites from 100% renewable resources that could be Colorado. The organization promotes drug discovery used in a wide variety of applications including medi- AMC Cancer Research Center research with Colorado through a combination of fund- cal device applications. Denver ing, medicinal chemistry and modeling expertise. www.amc.org Power Ecalene Fuels, Inc. AMC is a national, not for profit research institute Colorado School of Mines Arvada dedicated to the prevention and control of cancer and Golden powerecalene.com other chronic diseases. AMC is conducting innovative www.mines.edu Exclusive licensor of a patented nano-catalyst technol- and important research in the areas of cancer causation A public research university internationally recognized ogy that efficiently converts “syngas” or “producer gas” and prevention, behavioral research, nutrition, clinical for its leadership in engineering, applied science and into a premium mixed alcohol transportation fuel called and community studies and health communication. related disciplines, with a special emphasis on the Ecalene™. Ecalene™ is usable as a stand-alone fuel Earth and its resources. These programs, with strong for cars, trucks, buses, jet aircraft and boats. Biofrontiers Institute interdisciplinary linkages across the campus, have led Boulder to the integration of bioscience and biotechnology into PureVision Technology, Inc. biofrontiers.colorado.edu educational and scholarly activities. CSM has created Fort Lupton State-of-the art research and education facility that a Bioengineering and Life Science Program that draws www.purevisiontechnology.com links the basic sciences, engineering, clinical practice, upon faculty and students from all of the academic Develops a carbon-neutral biomass fractionation and industry at the University of Colorado’s Boulder units. technology that converts cellulosic biomass into sugars, campus. energy and fiber that are bio-based raw materials to Colorado State University make many industrial and consumer products. Biological Sciences Curriculum Study (BSCS) Fort Collins, Pueblo Colorado Springs www.colostate.edu Range Fuels www.bscs.org As one of the nation’s leading research universities, Broomfield A nonprofit corporation that endeavors to improve all Colorado State University is committed to realizing www.rangefuels.com Converts biomass that cannot be used for food into students’ understanding of science and technology by its vision as a 21st century land-grant university. CSU low carbon biofuels and clean renewable energy using developing exemplary curricular materials, support- leads the world in such areas as infectious disease emerging clean energy technologies. Biomass includes ing their widespread and effective use, providing research, atmospheric science and environmental sci- all plant and plant-derived material, such as wood, professional development, and conducting research and ence. Its faculty members are tackling such issues as switch grass, corn stover, and miscanthus grass – mak- evaluation studies. the reemergence of tuberculosis, the brown cloud of air ing it a renewable energy resource that produces no net pollution in Asian cities, severe weather forecasting, greenhouse gases. Bonfils Blood Center nutrition and wellness, and bioterrorism. In addition Denver to its excellent programs in those areas, CSU offers San Juan Bioenergy www.bonfils.org among the very best professional programs in the Dove Creek One of the nation’s leading community blood centers United States in areas like veterinary medicine, oc- www.sanjuanbio.com through their commitment to quality service, innova- cupational therapy, journalism, Master’s in Engineering Pressed oil seed facility in the heart of a developing oil tion, research and technology. They offer a full range with a Specialization in Biomedical Engineering and seed region. of blood products and services to healthcare partners Regulatory Affairs Certificate. including supplying rare blood units or helping to de- Solix Biofuels, Inc. termine the best cross-matched unit to endure the best CSU Research Innovation Center Fort Collins possible patient outcomes. Fort Collins www.solixbiofuels.com csuric.org Develops massively scaleable photo-bioreactors for the Centers for Disease Control and Prevention/Divi- The Research Innovation Center (RIC) serves as a production of biodiesel and other valuable bio-com- sion of Vector-Borne Infectious Disease vehicle to perform collaborative translational-stage re- modities from algae oil. Fort Collins search with CSU’s life sciences community of research- www.cdc.gov/ncidod/dvbid ers, giving it the promise to become the birthplace of Sterling Ethanol, LLC The Division of Vector-Borne Infectious Diseases medical breakthroughs. Sterling (DVBID) is part of the U.S. Centers for Disease www.sterlingethanol.com Control and Prevention (CDC). CDC is the lead federal Community College of Aurora (CCA) Produces 42 million gallons of ethanol annually, using agency for protecting the health and safety of people Aurora the distiller’s grain produced as a co-product of ethanol at home and abroad. DVBID serves as a national and www.ccaurora.edu to the areas cattle feeders for its high protein levels. international reference center for vector-borne viral CCA provides lifelong educational opportunities, pre- and bacterial diseases, such as West Nile virus, Lyme pares the current and future workforce, and promotes Sundrop Fuels, Inc. disease, plague, tularemia, yellow fever and dengue. Louisville excellence in teaching, learning and service. CCA www.sundropfuels.com It coordinates national disease monitoring activities, offers a unique Biotechnology Technician Research A solar gasification-based renewable energy company. conducts field and laboratory research, responds to and Development Certificate designed to train highly epidemic situations, develops strategies for disease skilled lab personnel for the biotech industry. ZeaChem prevention and control, provides diagnostic reference Lakewood and epidemiologic consultation, and conducts technical www.zeachem.com assistance and professional training activities. Developed a cellulose-based biorefinery platform capable of producing third-generation ethanol fuel and intermediate chemicals. Our indirect approach leapfrogs the yield and carbon dioxide (CO2) problems associated with traditional and cellulosic based ethanol processes.

BIOSCIENCE COLORADO 2012/2013 63 Research and Education Institutions

Colorado Institute for Drug, Device and Diag- for innovation and accelerating life science discovery. are nurtured and developed to become leaders in phar- nostic Development (CID4) Conferences are held in the Rocky Mountain West and macy practice, research, education, and public service. Aurora around the world in venues conducive to interaction As a result, students graduate as professionals who www.cid4.com and are planned by a peer review process drawing on are knowledgeable, skillful, and principled, and who CID4 provides management expertise to efficiently the expertise of pre-eminent life scientists. Founded in are able to make a positive impact on the dramatically transform emerging life science technologies into com- 1972 as UCLA Symposia, we are celebrating our 40th changing role of pharmacists in our transforming soci- mercial successes. We do this by identifying and funding anniversary in 2012. ety. They are educated to be committed to excellence potential opportunities, and by utilizing an advanced in healthcare, evidenced not only by their knowledge leadership team to ensure speed to market, putting new National Institute of Standards and Technology and abilities, but also by their quality of care, integrity, products and services to work where they are needed. (NIST) compassion, respect, advocacy, initiative, service and Boulder leadership. To achieve these goals, faculty members Denver Botanic Gardens www.nist.gov are dedicated to providing innovative practice models, Denver NIST is a non-regulatory federal agency that oper- exploring novel applications of basic and clinical www.botanicgardens.org ates eight different science and advanced technology research, and illustrating the value of lifelong learning. One of the top-ranked botanical gardens in the US, research divisions in Colorado. NIST’s list of research Regis University, a Colorado college, has been meeting Denver Botanic Gardens offers spectacular plant dis- accomplishments includes a NIST senior scientist win- the needs of students with campus education and online plays and unlimited opportunities for lifelong learning. ning the Nobel Prize in 2001 for creating the world’s programs centered in academic excellence. first “Bose-Einstein condensate.” In 2003 another NIST Denver Museum of Nature and scientist won a MacArthur Fellowship for discovering a Rocky Mountain Innosphere Science new quantum gas and was named by Science as one of Fort Collins Denver the top ten scientific advances of the year. www.rmi2.org At Rocky Mountain Innosphere (RMI), we are helping www.dmns.org The Denver Museum of Nature & Science is the Rocky National Jewish Health new clean energy, technology and scientific startup companies turn their great ideas into great businesses. Mountain region’s leading resource for informal sci- Denver These businesses, in turn, create high wage job oppor- ence education. A variety of exhibitions, programs, www.njhealth.org tunities for the community and fuel the growth of the and activities help Museum visitors experience the National Jewish Health, the nation’s #1 respiratory hos- industries of the future. natural wonders of Colorado, Earth, and the universe. pital in the US, attracts thousands of adult and pediatric patients each year who come to us to team up with our expert physicians and researchers and seek treatment Rose Medical Center DSST Public Schools (Denver School of Science Denver and Technology) for respiratory, cardiac, immune and related conditions. National Jewish Health is also one of the most www.rosemed.com Denver Has earned a reputation as Denver’s “Baby Hospital” www.dsstpublicschools.org influential independent biomedical research centers in the world. More than 100 faculty members conduct while becoming a leader in comprehensive women’s DSST Public Schools is dedicated to providing a di- services, internal medicine, endoscopy, heart and verse student body with an outstanding liberal arts high basic, translational, and clinical research in immunology, respiratory medicine, allergy, cancer, and cell vascular care, orthopedics and total joint replacement, school education with a science and technology focus. bariatric surgery, sports medicine and aesthetic surgery. By creating a powerful learning community centered and molecular biology. National Jewish Health ranks on core values and a shared commitment to academic among the top ten percent of all institutions for NIH support and for the impact of its research papers in the Rocky Vista University College of Osteopathic excellence, DSST will increase the number of under- Medicine (RVUCOM ) represented students (women, minorities and economi- fields of Molecular Biology, Genetics, and Biology and Biochemistry. Parker cally disadvantaged) who attain college science and lib- www.rockyvistauniversity.org eral arts degrees. DSST Public Schools operates three Rocky Vista University College of Osteopathic schools on two campuses, Stapleton (grades 6-12) and National Renewable Energy Laboratory Medicine (RVUCOM ) is one of the newest of the 28 Green Valley Ranch (6th). A third DSST campus, Cole Golden colleges of osteopathic medicine currently established Arts and Sciences, will open with a 6th grade in the www.nrel.gov or in development in the United States. With five de- fall of 2011. DSST: Stapleton is widely considered to The nation’s primary laboratory for renewable energy partments – biomedical sciences, structural medicine, be one of the leading open enrollment STEM schools and energy efficiency research and development primary care, Osteopathic Principles and Practices, (Science, Technology, Engineering and Mathematics) (R&D). NREL’s mission and strategy are focused Specialty Medicine and Medical Informatics the facul- in the U.S. and has become a destination for educators on advancing the U.S. Department of Energy’s and ty and staff of RVUCOM are committed to osteopathic nationwide. DSST: Stapleton has consistently been the our nation’s energy goals. NREL’s R&D areas of philosophy and heritage, and to advancing the science highest performing secondary school in DPS, based on expertise are: renewable electricity (solar, wind, and the art of the practice of osteopathic medicine. growth and absolute performance. DSST: Stapleton’s biomass, geothermal), renewable fuels (biomass, first four graduating classes earned 100% acceptances hydrogen), integrated energy system engineering and Scientific Education & Research Institute (SERI) into four-year colleges. Fifty percent of DSST’s 2010 testing (buildings, electric systems and transportation Thornton graduating class is first generation college-bound. infrastructures), and strategic development and analysis www.theseri.com (economic, financial, and market analysis, planning and SERI is a unique institute, which combines an orthope- Front Range Community College portfolio prioritization). dic clinic, specializing in spine surgery, with a clinical Brighton, Fort Collins, Longmont and Westminster research unit and and education and training program. www.frontrange.edu Poudre Valley Health System/ Medical Center Our facility has available to rent an amphitheater with Front Range Community College, Colorado’s largest of the Rockies full AV setup for presentations, as well as a bioskills lab community college, provides instruction, in both Loveland, Fort Collins with cadaveric dissection capabilities. We host a variety general education and occupational areas, which may www.pvhs.org of educational programs including summer science lead to a certificate, an associate degree, or transfer Poudre Valley Health System operates as a private, camps. Additionally we host a large number of training to a four-year institution. The college also provides not-for-profit organization providing a regional network programs sponsored by surgical and medical companies. college preparatory education, non-credit instruc- of health care services for the people of northern tion for personal and professional development, and Colorado, western Nebraska, and southern Wyoming. Swedish Medical Center workplace skill development. With campuses located The system is comprised of the Poudre Valley Hospital, Englewood in Fort Collins, Longmont and Westminster, the college the Medical Center of the Rockies, as well as several www.swedishhospital.com is proud of its many partnerships to provide quality community clinics that provide primary and specialized Level I Trauma Center, serves as the region’s referral programs that are responsive to the needs of its local medical services. Poudre Valley Hospital was named center for neurotrauma and is a recognized leader in communities. one of the nation’s top 100 hospitals for the fifth year, the treatment of stroke. An acute care hospital with 368 has been considered a Magnet Nursing Practice since licensed beds. Keystone Symposia on Molecular and Cellular 2000 and has been presented with the American Biology Nurses Association’s highest award for sustained over- United States Geological Survey (USGS) - Center Silverthorne all excellence in nursing quality. for Biological Informatics www.keystonesymposia.org Denver Keystone Symposia is a nonprofit organization Regis University biology.usgs.gov/cbi committed to connecting the scientific community Denver The Center for Biological Informatics, at the Denver across disciplines and borders by convening open, www.regis.edu Federal Center, operates the national Biological international conferences across the full range of the The School of Pharmacy aspires to be the foremost Information Infrastructure (NBII). This is the first com- biomedical and life sciences. We strive to be a catalyst school of pharmacy in the United States where students prehensive electronic gateway dedicated exclusively to biological science data and information from sources COLORADO BIOSCIENCE ASSOCIATION MEMBER throughout the world.

64 2012/2013 BIOSCIENCE COLORADO Member Foundations/MEMBER SERVICE PROVIDERS

University of Colorado Boulder, Denver, Aurora, Colorado Springs Member Foundations Member Service Providers www.cu.edu The University of Colorado System’s 52,000 students Boettcher Foundation and 28,000 faculty and staff contribute to every facet of Webb-Waring Biomedical Research Program Architecture life in Colorado. The state’s economic vitality, educated Denver workforce, entrepreneurial climate, cultural capital, www.boettcherfoundation.org BURKETTDESIGN, Inc. health care delivery, and scientific explorations all rely Founded by the Boettcher Family in 1937 to effectively www.burkettdesign.com on the driving force of a vigorous state university. By assist, encourage and promote quality of life for the working with other CU academic and research units, citizens of Colorado, the Boettcher Foundation invests Rosenman Associates Architects as well as local, state, and federal funding agencies, in education, community services, health, and arts & www.rosenman-arch.com commercial business, and nonprofit organizations, CU culture through merit awards, scholarships and capital is creating a collaborative synergy in important areas grants. In 2008, the Webb-Waring Institute became a Construction and Facilities that will better the wellness of society. The CU Institute part of the University of Colorado and is now known CH2M Hill of Bioenergetics,BioFrontiers Institute, the Center for as the Webb-Waring Center. The Boettcher Foundation was entrusted with the stewardship of the Webb-Waring www.ch2m.com Computational Biology, and the Center for Pharma- ceutical Biotechnology attract intellectual strength to Foundation’s assets. Through an innovative agreement between the Boettcher Foundation, the Webb-Waring CRB Engineers and Builders Colorado, provide new educational opportunities, and www.crbusa.com inspire innovative health care advances. Research Foundation and the University of Colorado, a new funding area was established at the Boettcher Founda- and teaching hospitals affiliated with the University Facility Planning Arts of Colorado include: The University of Colorado tion that supports the work of early-career investigators in the biomedical sciences in Colorado. www.planningartsinc.com Hospital, The Children’s Hospital, National Jewish Medical and Research Center, Denver Health and the Howell Construction Childrens Hospital Colorado Foundation VA Medical Center. www.howellconst.com Aurora University of Denver www.childrenscoloradofoundation.org The Whiting-Turner Contracting Co. In 1978, Children’s Hospital Colorado Foundation was Denver www.whiting-turner.com www.du.edu formally established as a separate charitable 501(c)(3) Strives to provide the most modern educational and organization dedicated solely to advancing the mission Whitestone Construction Services, Inc research facilities in the life sciences. Their history of Children’s Hospital Colorado. www.whitestone-construction.com spans the Denver Research Institute’s development of the first NASA life monitoring sensors, the establish- Colorado State University Research Foundation Consulting - General Business ment of a state-of-the-art forensics laboratory, to the (CSURF) 2003 acquisition of the Eleanor Roosevelt Institute Fort Collins CBIZ MHM, LLC with pioneering efforts in genomics and bioinformat- www.csurf.org www.cbiz.com ics. In 2004, CSURF is a private, not-for-profit Colorado Corpora- tion established (in 1941) to aid and assist the Univer- Neil Burris & Associates the School of Engineering and Computer Science sity campuses (Colorado State University and recently [email protected] unveiled Colorado’s first undergraduate program in Colorado State University Pueblo) governed by the Bioinformatics and a master’s degree in Bioengineer- Board of Governors of the Colorado State University Peak to Peak Pharmaceutical Associates ing. The interdisciplinary mission of the University System in their research and educational efforts. peaktopeakpharma.com enabled the Department of Biology to launch new Functions include patent and licensing management; emphases in Bioengineering, Biophysics and Cognitive equipment leasing and municipal lease administra- Your Bio Team Neuroscience designed for molecular biology majors. tion; financing of equipment, real estate and buildings www.yourbioteam.com In addition to strong and quality curricula, bioengineer- through mortgage debt obligation(s); and land acquisi- ing and life sciences at DU carry multimillion-dollar-a- tion, development and management. Consulting - Regulatory, year research studies in the creation of new knowledge Commercialization and Development and leading edge biotechnologies to improve quality of Medical Center of the Rockies Foundation life for a worldwide community. Loveland, Fort Collins BioNimbus, Inc. pvhs.org/mcrfoundation www.bionimbus.com University of Northern Colorado The Medical Center of the Rockies Foundation was Greeley created to support the cutting-edge research opportu- Decus Biomedical www.unco.edu nities and educational advancements that have been www.decusbiomedical.com University of Northern Colorado (UNC) is a multi- established since the opening of Medical Center of the purpose institution with a wide range of graduate and Rockies. E3 Medical, Inc undergraduate programs. The university’s mission is www.e3medicalinc.com to prepare individuals for advanced study, professional University of Colorado Foundation Emerson Consultants, Inc. careers, and positions of leadership. Boulder www.cufund.org www.emersonconsultants.com

Work, Education and Lifelong Learning Simula- The University of Colorado Foundation is a privately governed nonprofit corporation whose mission is to Evolve Biosciences LLC tion (WELLS) Center www.evolvebiosciences.com Aurora support the University of Colorado. As a valued and trusted partner, the University of Colorado Foundation www.wellssimulationcenter.org Health Perls For the first time in Colorado, one facility offers a com- generates the private support needed in perpetuity for plete array of state-of-the-art patient simulation tools CU to achieve international preeminence as a public for building clinical knowledge. Even more exciting, research university. Our donors enable CU to reach its LCC Consulting, LLC high-speed datacasting technology makes this unique full potential to transform lives world-wide through www.lccconsulting.net resource available remotely. Students, faculty and prac- education, research, clinical care and community ticing nurses and physicians from throughout Colorado service. Reglera, LLC can enhance their diagnostic and clinical skills at the www.reglera.com WELLS Center either on-site or on-line.Housed in the new Bioscience East building at Fitzsimons, the Clinipace Worldwide/ Regulus Pharmaceutical WELLS Center represents a unique collaboration Consulting, Inc. among educators, providers and policymakers. www.reguluspharma.com

BIOSCIENCE COLORADO 2012/2013 65 MEMBER SERVICE PROVIDERS Contract Research Organizations Distribution, Packaging and Sales Force Finance, Investment and Financial Services

Absolute Science, Inc CGL - Concert Group Logistics Commerce Bank www.absolutescience.com www.cglship.com www.commercebank.com

CBR International Corporation Pozzetta Scientific Eide Bailly LLP www.cbrintl.com www.pozzettascientific.com www.eidebailly.com

Colorado Histo-Prep (CH-P) Economic Development EKS&H (Ehrhardt Keefe Steiner & Hottman) www.histoprep.com www.eksh.com Adams County Economic Development, Inc. (ACED) CPC Clinical Research www.adamscountyed.com Emergent Global www.cpcmed.org www.emergentglobal.com Arvada Economic Development Association DaVita Clinical Research (DCR) www.aeda.biz Ernst & Young www.davitaclinicalresearch.com www.ey.com Aurora Economic Development Council High Quality Research, LLC (HQR) www.auroraedc.com Fabiani & Company www.hqrllc.com www.fabiani-co.com Boulder Economic Council LABS, Inc. www.bouldereconomiccouncil.org FirstBank www.labs-inc.org www.efirstbank.com Broomfield Economic Development Corporation MPI Research (BEDC) Forbes Mergers & Acquisitions www.mpiresearch.com www.broomfieldedc.com www.forbesma.com

NextGen Pharma Technologies, Inc. Canadian Consulate Grow, LLC www.nextgenpharma.com www.international.gc.ca www.grow-ec.com

PCM TRIALS City & County of Broomfield Headwaters MB www.pcmtrials.com www.broomfield.org www.headwatersmb.com

Plato BioPharma, Inc. City of Westminster Hein & Associates, LLP platobiopharma.com www.ci.westminster.co.us www.heincpa.com

Premier Laboratory, LLC City of Westminster Economic Development Office High Country Venture LLC www.premierlab.com www.ci.westminster.co.us www.coloradofund1.com

Pre-Clinical Research Services, Inc. Colorado Office of Economic Development and Morgenthaler Ventures www.preclinicalresearch.com International Trade (OEDIT) www.morgenthaler.com www.advancecolorado.com Pyxant Labs, Inc. Oliver Investment Banking www.pyxant.com Colorado Rhône-Alpes Economic Development www.oliverinvestmentbanking.com Partnership (CORA) RMC Pharmaceutical Solutions Incorporated www.coranetwork.org OnBioVC (RMC) www.OnBioVC.com www.rmcpharma.com Colorado Small Business Development Center www.coloradosbdc.org Silicon Valley Bank (SVB Financial Group) Contract Manufacturing/Design www.svb.com Organizations Denver South Economic Development Partnership www.denversouthedp.org TaxOps LLC Die Cut Technologies Inc www.taxops.com www.diecuttech.com Greater Colorado Springs Chamber and EDC www.csedc.org UMB Bank Evergreen Research, Inc. www.umb.com www.evergreenresearch.com Jefferson County EDC www.jeffco.org Wells Fargo Bank N.A. www.wellsfargo.com Mountainside Medical Metro Denver Economic Development Corpora- www.mountainsidemed.com tion Incubator www.metrodenver.org Vention Medical Innovation Center of the Rockies www.ventionmedical.com South Metro Denver Chamber of Commerce www.boulderinnovationcenter.com www.bestchamber.com Fitzsimons BioBusiness Incubator in the Colorado TOWN of Parker Science and Technology Park at Fitzsimons www.parkeronline.org www.FitzScience.com

Colorado Springs Technology Incubator (CSTI) www.cstionline.org

66 2012/2013 BIOSCIENCE COLORADO MEMBER SERVICE PROVIDERS

IT/ AV Marketing, Communications and Public Policy Public Relations Digital Roads PhRMA www.digitalroads.com Absolutely Public Relations www.phrma.org www.absolutelypr.com Intuitive Technical Solutions, Inc. We Work for Health www.itscorp.com Aegis Creative www.weworkforhealth.org www.aegiscreative.com Insurance Real Estate The Bawmann Group CoBiz Insurance/CoBiz Financial www.morethanpr.com Fitzsimons Life Science District www.cobizins.com www.colobio.com Biolexica The Travelers Companies, Inc. www.biolexica.com www.travelers.com Forest City Stapleton www.forestcity.net The Wright Group, Inc. www.twgservices.com Jones Lang LaSalle www.joneslanglasalle.com Willis www.willis.com Forte Commercial Real Estate www.fortecre.com Legal Services Recruiting, Placement, and Workforce Cooley LLP www.cooley.com Aerotek Inc. www.aerotek.com Dorsey & Whitney LLP www.dorsey.com Arapahoe/Douglas Works! Workforce Center www.adworks.org Faegre Baker Daniels LLP www.faegrebd.com Continuum Search Burns Marketing Communications www.continuum-search.com Fairfield and Woods PC www.burnsmarketing.com www.fwlaw.com Jefferson County Workforce Center Business Wire www.jeffcoworkforce.org Fennemore Craig PC www.businesswire.com www.FennemoreCraig.com Casey Demchak Copywriter & Consultant Kelly Scientific Resources Greenlee Sullivan PC www.caseydemchak.com www.kellyscientific.com www.greenwin.com Global Prairie Prime-Core, Inc. Gross Hartman LLC www.global-prairie.com www.prime-core.com grosshartmanlaw.com Griff/SMC Medical Marketing Supplier/Equipment/Disposal-Lab Hogan Lovells US LLP Communications www.hoganlovells.com www.griffsmc.com Anacor Compliance Services www.anacorcompliance.com Husch Blackwell LLP Growl Healthcare Agency www.huschblackwell.com www.GrowlAgency.com Colorado Medical Waste, Inc. www.coloradomedicalwaste.com Larson & Anderson LLC Hillside Communications, Inc. www.himtnpatents.com www.hillsidecommunications.com Extronex, Inc. www.extronex.com Polsinelli Shughart PC Heim & Associates, Inc. www.polsinelli.com www.linkedin.com/in/steveheim Fisher Scientific www.fishersci.com Roberts & Olivia LLC HOWE Creative www.wrrlaw.com www.howecreative.com Thermo Fisher Scientific, Inc.

www.dharmacon.com Sheridan Law LLC Sprint Press www.sheridanlaw.com www.sprintdenver.com Technical Safety Services www.techsafety.com Sheridan Ross PC The Text Doctor LLC www.sheridanross.com www.textdoctor.com

Snell & Wilmer Ubiquity Group www.swlaw.com www.ubiquity-design.com

Swanson & Bratschun LLC Unleaded Group www.sbiplaw.com www.unleadedgroup.com

BIOSCIENCE COLORADO 2012/2013 67

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Size: (H) 10.875 x (W) 8.25 Created by: peggy kraus Submission due date: 4/1/2012 Publication/event: Bioscience Colorado Magazine on 6/18/2012