Scientific Program

2014 Annual Meeting and Exhibits Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Scientific program

leading since 1999 ISBER 2014 Annual Meeting & Exhibits ‘Fact not Fantasy: Evidence-Based Biobanking’ May 20-24, 2014 • Orlando, FL, USA

ISBER Vision ISBER will be the leading global forum for promoting harmonized high quality standards, ethical principles, and innovation in the science and management of biorepositories.

ISBER Mission ISBER is a global organization which creates opportunities for sharing ideas and innovations in biobanking and harmonizes approaches to evolving challenges for biological and environmental repositories.

International Society for Biological and Environmental Repositories Head Office: 570 West 7th Avenue, Suite 400, Vancouver, BC, V5Z 1B3, Canada

T: 1-604-484-5693 • F: 1-604-874-4378 • E:[email protected] www.isber.org

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

ISBER 2014 Corporate Partners ISBER gratefully acknowledges the generous support of our Corporate Partners:

Platinum Corporate Partners

Gold Corporate Partners

www.isber.org Table of Contents Message From Scientific Program Committee & President 5

ISBER 2013 – 2014 Board of Directors 9

ISBER Committees & Working Groups 10

ISBER 2014 Award Winners 11

General Information 12

Venue Map 13

Exhibition Plan & List Of Exhibitors 14

Exhibition Passport 20

Pre-Conference Workshops 22

Scientific Program 24

Invited Speaker Summaries 33

ISBER Education & Training Workshops 36

Posters 44

2014 Annual Meeting Sponsors 50

Speakers & Chair Index 62

Poster Index 62

International Society for Biological and Environmental Repositories Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014 Message from the Scientific Program Committee and President Dear Colleagues and Friends, Friday morning, Symposium 4 will focus on “Biospecimen Science” and our final plenary in the ISBER program is on Saturday, “Biospecimen Welcome to the 2014 Annual Meeting & Exhibits of the International Identifiability, Privacy and Broad Data Sharing.” Society for Biological and Environmental Repositories (ISBER). The ISBER Annual Meeting & Exhibits provides a global forum for discussion Special Topic Sessions: of a broad range of issues related to the establishment and operation of a wide variety of biorepositories including human, animal, seed, museum Wednesday’s activities will open with a “Getting to Know ISBER” and environmental collections. Breakfast Session for any new or potential members. This is a valuable chance to meet and ask questions of several ISBER members that have Meeting Highlights: been highly involved in the Society. You will hear some of the history of ISBER and meet several of the Council members. We are happy to explore a new locale for the ISBER meeting, in sunny Orlando, Florida, USA, the theme park capital of the world. Our meeting On Thursday mid-morning, ISBER will host a session highlighting is being held in the Walt Disney World Swan and Dolphin Hotels, near Innovative Technologies. The focus of this session will be on the science Walt Disney World, Universal Studios and SeaWorld. ISBER is the only and validation behind new products and technologies that have the global forum serving all members of the biobanking community and the potential to impact biorepository operations and specimen management/ ISBER Annual Meeting & Exhibits continues to be the key meeting for workflow. Presentations were selected from the abstracts submitted to biorepository operators, scientists, consultants and vendors. the “Innovative Technologies” category. On Friday afternoon, a special topic session on “Important Biobanking Developments in Europe” The 2014 Scientific Program Committee has worked extremely hard this past will run concurrently with our annual Interactive Discussions. The year on our theme of “Fact not Fantasy: Evidence-Based Biobanking.” interactive discussions are focused on late breaking and special interest With the meeting held in an environment surrounded by fantasy, the main topics that are submitted by the ISBER membership. Please sign up for the focus will be on evidence-based biobanking from collection to use. The Interactive Discussions at the ISBER Registration desk to assure a seat at meeting will highlight unique and interdisciplinary best practices of both one of the tables. human and environmental repositories with regard to sample integrity, availability, interrogation and reliability of results. These explorations Working Group Meetings and Contributed Papers: will accelerate the biobanking community toward improved repository management, leading to better scientific decisions and enhanced global You will note that each day, meetings are scheduled for the ISBER Working and environmental health. Groups and Special Interest Groups. Please feel free to join any of the open sessions, the schedule is listed in the program. Plenary Symposia: It is very encouraging that we have received our largest number of We have invited world leaders in the field of biobanking and beyond submitted abstracts 209 yet – to our ISBER Annual Meeting & Exhibits and who will emphasize the rapidly evolving research environment and the all of the accepted abstracts are in the online abstracts that are published importance of having repositories practices adhering to processes that online in the April issue of Biopreservation and Biobanking (BIO). have been shown to be most effective in maintaining the specimens as true From the submitted abstracts, we have selected 33 oral presentations to to their in vivo state as possible. The speakers in Symposium 1 (Wednesday be presented on Thursday and Friday afternoon. In the exhibit hall, there morning) will report their experiences that highlight “Advancing will be 159 posters displaying the richness and diversity of the interests Science through Evidence-based Biobanking.” In the Keynote of ISBER members, providing you with a great opportunity to learn and presentation, Dr. Rex Chisholm presents “Integration of Biobanks interact with presenters on a wide variety of biobanking topics. Authors into Clinical Health Care through Linkage to Medical Records—The were required to submit their posters early to be eligible to be judged for eMERGE experience.” This is followed by “The Australian Plant Bank the ISBER Outstanding Poster Awards. – Safeguarding Plants for the Future” (Dr. John Siemon), “Geisinger’s MyCode Project: Leveraging Genomics and EMR Data to Improve High Variety of ISBER Activities: Patient Outcomes” (Dr. David Ledbetter), and finally “Cell Processing Educational and corporate workshops, contributed oral and poster and Preservation for Biobanking: New Horizons” (Dr. Erik Woods). presentations, exhibits, and two receptions are planned to complete This session sets the theme of our meeting. On Wednesday afternoon, your experience. We encourage you to spend time in our largest vendor Symposium 2 is entitled “Translational Science through Biobanking: exhibition to date. Applications and Opportunities.” Wednesday will end with the Opening Reception to visit posters, exhibits and to connect with friends There are nine Education and Training Pre-Conference Workshops scheduled and colleagues. Thursday morning features two concurrent symposia for the Tuesday morning, May 20, preceding the meeting (three concurrent that both will feature talks and an interactive discussion. Symposium tracks). These cover a range of topics including: “Fit for Purpose” Protocol 3A highlights issues of “Financial Sustainability of Biobanks” Planning: A Tutorial to Facilitate Evidence Focused Biobanking and Symposium 3B focuses on “Model Organisms and Biodiverse Practice – in Real Time”, “Surveys, Migration, and Changes – Biorepositories: Interdisciplinary Perspectives in Biobanking.” On Informatic Considerations for Biobanks”, “Are You Prepared? Case

www.isber.org Studies in Balancing Biospecimen-related Patient and Investigator 5K Fun Run/Walk: Requests with Risk Management and Human Subjects Protections rd in the Age of Genomic Medicine,” “Implementing Robust Quality The Membership and Marketing Advisory Committee has planned the 3 Management Systems for Repositories”, “Biospecimen Science: Annual ISBER 5K Fun Run/1M Walk/Sleep Walk on Thursday morning. Learning from Cryobiology to Improve Preservation Outcome”, We thank Taylor-Wharton for its generous support. Special thanks to Jay “Keep Your Samples Safe: Choose the Appropriate Storage Yakabowich for leading the Fun Run subcommitee efforts! All proceeds Container”, “Limitations in the Use of Human and Animal Tissues in raised from the Fun Run will benefit the ISBER Global Expansion Fund Research: What Biorepositories and Investigators Need to Know”, which supports the Society’s efforts to increase involvement and and “Issues to Consider in Designing a Repository / The Nuts and membership of researchers worldwide. The fund provides travel support Bolts of Operating a Repository”. Two of the Pre-Conference Workshops for individuals from emerging countries to attend the ISBER Annual are part of the ISBER Certified Repository Technician Program and are Meeting & Exhibits. We have two biobankers from Nigeria and Uganda in entitled, “Essential Concepts for Effective Specimen Receipt” and attendance at ISBER 2014 due to the generous support provided by the “Creating Successful Training Programs for Repository Staff.” proceeds of previous ISBER 5K Fun Run/Sleep Walk. Online and onsite registration for the 2014 ISBER 5K Fun Run/Sleep Walk is available at the There are also special workshop sessions on “Come Hell or High Water: registration desk. Sign up today! Disaster Preparedness for Biospecimen Collections” by Nigel Brockton, Charlene Karvonen, “Informed Consent for Genomics: Policies, Special Acknowledgements: Problems and Practical Approaches” by Marianna J. Bledsoe, Amelia We gratefully acknowledge all who provided so much input and effort into Warner, Anita Nelsen, “Weathering the Storm: Assessing Business the planning and implementation of the meeting. A special thank you to Continuity Measures in Biorepository Operations” with Kristina Dr. Bas de Jong for his contribution to the 2014 Scientific Program. Many Robson and Andrew Brooks and “ELSI Challenges in Biobanking & thanks to the members of the ISBER 2014 Scientific Program Committee, Genomics Research” with Pedro Rondot Radío, Rosario Isasi, Anne and the Organizing Advisory Committees, to the Chairs and members Marie Tassé within the main program on Saturday morning. of the ISBER Education and Training Advisory Committee, the ISBER ISBER Awards Presentation and Business Meeting: Membership and Marketing Advisory Committee, the ISBER Publications Advisory Committee, the ISBER Board of Directors and to the ISBER Head The ISBER Awards Presentation and Business Meeting will include an Office staff. We also thank our invited speakers and workshop presenters overview by ISBER President, Fay Betsou, of the accomplishments of our for their contributions to the program. Finally, we sincerely appreciate the society over the past year, ISBER’s finances, and major changes in ISBER’s support from our vendors, sponsors and corporate partners, without whom strategic vision for the membership and attendees. We encourage all the meeting would not be possible! We hope that the scientific program meeting participants to attend the business meeting. Special Service organized by the Program Committee will meet your highest expectations. Awards and the ISBER Distinguished Leadership and Service Award will To guarantee future successful meetings we will need your help, either by be presented. ISBER is excited to have Taylor-Wharton as the sponsor of joining the different committees and workshops, or by filling out the online the 5th ISBER Award for Outstanding Achievement in Biobanking, which meeting survey that is sent to all participants at the end of the meeting. will be presented during the meeting. We will also announce the results of the recent ISBER elections. Please attend to meet your new President- We look forward to your participation and we are looking forward to a Elect and ISBER Directors-at-large. We will also hold the draw for the successful Annual Meeting & Exhibits. We welcome both our established exhibitor passport prize – you must be present to win! and new colleagues to this event! We hope that our new colleagues will consider joining our Society as members to take advantage of the year- The poster awards will also be announced and presented during round interactions that our members enjoy. Our Society continues to the Business Meeting. To be eligible to be judged for these awards, the grow globally stronger, as we represent more sectors of our biorepository poster submissions must have been sent in early to the ISBER Head Office. community, and we welcome your participation. Enjoy reconnecting with Thank you for active participation in these programs. current friends and making new ones. The biorepository field is exciting and undergoing rapid change and ISBER will help chart the future course The ISBER Poster Awards recognize excellence in poster presentations with your participation! at the annual meeting. This year the awards will be limited to investigators who are new in biobanking. The goal of the ISBER Poster Award is to Thank you for your participation and enjoy the meeting. encourage ISBER members and all attendees of the annual meeting who With kind regards, are new investigators in biobanking to ask important original questions about biobanking and biospecimen science, to design sound, controlled Jodi Black, PhD, MMSc • Marianne K. Henderson, MS experiments with a clear rationale, and to present the results clearly in Co-Chairs of the ISBER 2014 Scientific Program Advisory Committee a poster format. Award winning posters will be selected by an Awards Subcommittee of the ISBER Puvblications Committee. The award, which Fay Betsou, DrSc HDR includes a stipend and award certificate, will be presented to the new ISBER President, 2013-2014 investigator at the ISBER Business Meeting.

International Society for Biological and Environmental Repositories Open Workshop Enter our tube game to win a kindle Fire & Networking Event at booth #207/306

Attend TTP Labtech and CryoXtract’s joint workshop: Managing the past for the future May 20th, 5.15pm – 6.15pm (post workshop refreshments will be available)

Learn about innovative workflow solutions for maintaining sample integrity at discover.ttplabtech.com/ISBER2014

ISBER 2014 Scientific Program

ISBER 2013-2014 Board of Directors

BOARD OF DIRECTORS President Treasurer Secretary-Elect Director-at-Large May 2013 – 2014 May 2013 – 2014 May 2013 – 2014 May 2012 – 2015

Fay Betsou, DrSc HDR Cheryl Michels Katherine Sexton, MBA Paul Bartels, PhD, BVSc Luxembourg Mountlake Terrace, WA, Birmingham, AL, Pretoria, United States United States South Africa President-Elect May 2013 – 2014 Secretary Director-at-Large Director-at-Large May 2013 – 2014 May 2011 – 2014 May 2012 – 2015 Andy Zaayenga Treasurer-Elect Martinsville, NJ, Lori Campbell, PhD Rebecca Pugh, MS United States May 2014 – 2017 Manassas, VA, Charleston, SC, Heather Siefers, MS United States United States Past President Rockville, MD, May 2013 – 2014 Director-at-Large Director-at-Large United States May 2011 – 2014 May 2013 – 2016 Katheryn E. Shea Frederick, MD, Jane Carpenter MAppSci, FIBMS Brent Schacter, MD FRCPC United States Westmead, NSW, Winnipeg, MB, Australia Canada

Education and Training Science Policy Advisory 2014 Scientific Program Organizing Advisory Advisory Committee Committee Co-Chairs Advisory Committee Co-Chairs Committee Chair Co-Chairs Nicole Sieffert, CCRC Jodi Black, PhD, MMSc Marianne Henderson, MS Nicole Sieffert, CCRC Houston, TX, Bethesda, MD, Bethesda, MD, Houston, TX, United States United States United States United States Tyron C. Hoover, MD, JD FCLM FCAP Marianne Henderson, MS Executive Director Alexandra F. Lerch-Gaggl, MSc, PhD Houston, TX, Bethesda, MD, Sarah McCarthy, MSc, MBA Milwaukee, WI, United States United States Vancouver, BC, USA Nikolajs Zeps, PhD Canada Publications Advisory Perth, WA, Committee Chair Australia

Marianna Bledsoe, MA Membership and Marketing Washington, DC, Advisory Committee Chair United States David Lewandowski Poway, CA, United States

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Isber Commitees 2013-2014

Executive Committee Governance Committee Advisors Education and Training Advisory Committee President: Fay Betsou Antonio Hugo Campos Chair President-Elect: Andy Zaayenga Karen Suzanne Meir Past President: Katheryn Shea Heather Siefers Alison Parry-Jones Co-Chairs Secretary and Treasurer-Elect: Christina Schroeder Alexandra Lerch-Gaggl Heather Siefers Members Laura Weaver Nicole Sieffert Andy Zaayenga Treasurer: Cheryl Michels Cheryl Michels Nik Zeps Members Transition Liaison: Katherine Sexton Marianne Henderson Katheryn Shea Ex Officio Erica Benson Nicole Sieffert Fay Betsou Fay Betsou Jane Carpenter Audit and Finance Jane Carpenter Debbie Garcia Committee Cheryl Michels Judith Giri ScientificP rogram Brent Schacter Advisory Committee Kristina Hill Chair Lise Matzke Lisa Miranda Cheryl Michels Co-Chairs Organizing Advisory Sheila O’Donoghue Jodi Black Committee Members Advisors Marianne Henderson Fay Betsou Chair Marianna Bledsoe Scott Jewell Members Karen Pitt Marianne Henderson David Lewandowski Jason Acker Katherine Sexton Katheryn Shea Kyung-Sook Ahn Members Heather Siefers Paul Bartels Andy Zaayenga Jodi Black Science Policy Advisory Anna Beskow Sheila O’Donohue Marianna Bledsoe Andy Pazahanick Committee Koh Furuta Nominating Committee Brent Schacter Galen Hostetter Daniel Simeon-Dubach Co-Chairs Olga Kofanova Menhong Sun Chair Tyron Hoover Zisis Kozlakidis Fay Betsou David Lewandowski Nicole Sieffert Katheryn Shea Cheryl Michels Nikolajs Zeps Maimuna Mendy Heather Siefers Members Piper Mullins Andy Zaayenga Members Rebekah Rasooly Elaine Gunter Marianna Bledsoe Marianne Henderson Melissa Rawley Payne Kristen Rosati Lisa Gilbert Helen Morrin William Grizzle Alison Parry-Jones Katheryn Shea Sylvia Silver Paula Kim Peter H. J. Riegman Yeonhee Lee Amelia W. Warner Helen Moore Fay Betsou Helen Morrin Amelia Warner Wendy Wolf

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

Membership and Publications Advisory ISBER Working Groups Marketing Advisory Committee Committee • Biospecimen Science • Environmental Biospecimens Chair • Hospital-Integrated Biorepositories Chair Marianna Bledsoe • Informatics • Regulatory and Ethics Working Group David Lewandowski Members (Formerly the Informed Consent Procedures for the Collection Vice-Chair Roger Aamodt of Biospecimens) Elaine Gunter Lori Campbell • Integrated Biobanking Workflows William E. Grizzle • International Repository Locator Members Elaine Gunter • Rare Diseases Phil Baird Scott Jewell • Rights to and Control of Human Tissue Samples Luke Bradshaw Peter Riegman • Trans-Omics David Carpentieri Brent Schacter Debra Garcia Daniel Simeon-Dubach Marianne Henderson Peter Watson ISBER Special Interest Groups Rick Michels Newsletter Editor-in-Chief Alison Parry-Jones • Automated Repositories Heather Siefers Rick Michels • Management of Investigator-Returned Research Results Daniel Simeon-Dubach Vice-Chair and Jay Yakabowich BIO Editor in Chief Andy Zaayenga Jim Vaught

ISBER 2014 Award Winners

ISBER Distinguished Leadership & Service Award ISBER Special Service Award

This award is designed to honor ISBER members who have demonstrated The ISBER Special Service Awards recognize individuals who have made exceptional leadership to further the mission and goals of the society and/or exceptional contributions towards the goals of the Society through the significant, long-standing contributions to the society. performance of a special service or act on behalf of the organization.

Rita Lawlor (Italy) Peter Watson, MB, BChir FRCPC (Canada)

Brent Schacter, MD, FRCPC (Canada) ISBER Award for Outstanding Achievement in Biobanking ISBER Travel Award

The ISBER Award for Outstanding Achievement The ISBER Global Expansion Fund supports efforts to increase ISBER’s in Biobanking, sponsored by Taylor-Wharton, is membership and presence world-wide. The ISBER Travel Award provides travel designed to recognize individuals who have made support for individuals from emerging countries who are planning, or are outstanding contributions to the field of biobanking. currently managing, a repository to attend the ISBER Annual Meeting.

Yeonhee Lee, PhD (South Korea) Sureyah Nassimbwa (Uganda)

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

General Information Venue 5K Fun Run/1M Walk/Sleep Walk Walt Disney Dolphin Hotel • $30 USD Pre-Registration 1500 Epcot Resorts Blvd, Lake Buena Vista, Florida 32830, United States • $40 USD On-Site Registration Meeting Dates: May 20-24, 2014

Registration Pre-Conference Workshops (separate registration required): Opening Hours: See page 36 for details. Tuesday, May 20 06:45 – 17:30 Workshop Registration Fee (USD) Wednesday, May 21 07:00 – 18:00 Thursday, May 22 07:00 – 18:00 Workshop 1A $72 Friday, May 23 07:00 – 18:00 Workshop 1B $72 Saturday, May 24 07:00 – 13:00 Workshop 1C $72 Exhibit Hours: Workshop 2A $72 Wednesday, May 21 10:30 – 18:30 Workshop 2B $72 Thursday, May 22 09:30 – 18:00 Workshop 2C $72 Friday, May 23 09:30 – 16:00 Workshop 3A $125 Speaker Services (Pacific C): Workshop 3B $100 Tuesday, May 20 06:45 – 14:45 Workshop 3C $100 Wednesday, May 21 07:30 – 15:30 Thursday, May 22 08:00 – 16:00 Friday, May 23 08:00 – 16:00 Poster Presentation Instructions Saturday, May 24 08:00 – 13:00 ODD Numbered Posters EVEN Numbered Posters Annual Meeting Registration (Prices in USD) Poster Set up: Poster Set up: Wednesday May 21 Thursday May 22 Regular Rate On-Site Rate 12:00 – 12:30 15:30 – 16:00 Member $925 $1,050 (onsite poster boards will provide the abstract number) Non-Member $1,225 $1,350 Presentation: Presentation: Technician $675 $695 Thursday May 22 Friday May 23 12:30 – 13:30 11:30 – 12:30 One Day Pass $495 $495 (all presenters must be by their posters during this time frame) Posters Take Down: Posters Take Down: Full Conference Registration: Thursday May 22 Friday May 23 • Includes participation in all scientific sessions, delegate bag, 14:00 – 14:30 18:00 – 18:30 refreshments during breaks, and Opening and Closing Ceremonies. (Posters that are not removed will be taken down)

Exhibit-only attendees: • Access to the Exhibit Hall, conference meals served in the Exhibit Hall, and access to the Abstract Poster Networking Event. Scan this code and download the Final Program directly to your phone or tablet. Certificates of Attendance: • All attendees will receive a certificate of attendance by email after the meeting.

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

Venue Map Meeting room Sales Offices

4 1 Meeting 765 oceanic 3 2 1 Foyer Service 3 rooms Asia australia 1 2

Ground Level 2 speaker prep room Hotel Lobby

3 Public Phones

Convention Services Europe Offices 8 7 6 5 4 3 2 1 5 europe 9 Elevator

europe Convention 10 11 Entrance/Departure Meeting rooms Women Men escalators Main Meeting rooms & exhibit

Level -1

East Sidewalk Drive-Up Access

poster area Pacific A Pacific Hall B Pacific C Atlantic Hall Pacific Terrace ABC Escalators to Plenary Exhibit Hall Concurrent Meeting Rooms speaker services Pacific Hall Foyer Atlantic Hall Foyer Convention Registration Atlantic Hall Foyer Elevator Entrance/Departure Desk

enter

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Exhibition Floor Plan

120 120a 121 222 220 Posters

118 117 216 217 316 317 416 419

118a 115a 214a 215a 314a 315a 414a 417

116a 415a

116 115 214 215 314 315 414 415

114 113 212 213 312 313 412 413

112 111 211 310 410 411

110 409a

108 107 206 207 306 307 406 409

106 105 204 205 304 305 404 407

104 103 202 203 302 303 402 405

102 101 200 201 300 301 400 403

Entrance Entrance

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program Exhibitors

Booth Booth Exhibitor Company Exhibitor Company Number(s) Number(s) Airgas 220 Hamilton Storage Technologies 212 Artificial Intelligence in Medicine Inc. 404 HighRes Biosolutions 222 ASKION GmbH 101 IMV Technologies / Cryo Bio Systems 403 AstridBio Technologies Inc. 314 ISENET-USA LLC 412 AutoGen Inc. 105 Kairos GmbH 414 Autoscribe Limited 120a KAYE 305 Bahnson Environmental Specialties, LLC 303 LabVantage Solutions, Inc. 102 BASF / Metanomics Health 112 Liconic 313 BioCision 113 Mayo Clinic Bioservices 315 BioFortis 213 Mesa Labs 116a Biolife Solutions 215a Micronic 104 Biologix Group Limited 108 MVE Chart 201, 300 BioMicroLab 114 NHLBI – BioLINCC. 413 Biosero, LLC 203 Pacific Bio-Material Management, Inc./ 204 BioStorage Technologies 216 Novare Bio-Logistics Brady Corporation 304 Panasonic 314a, 316 Brooks Life Science Systems 211, 310 Praxair 406 BSI Systems / Information Management Services 307 Precision Bioservices 120 caTissue Plus 419 Promega 215 chemagen from PerkinElmer, Inc. 317, 416 Rees Scientific 121 CloudLIMS 302 RUCDR Infinite Biologics 117 Coldstash 402 Ruro, Inc. 312 College of American Pathologists 110 Scinomix Inc. 417 Computype 409a Sequenom 118a Coriell Institute for Medical Research 411 So-Low Environmental Equipment Co., Inc. 106 Cryoxtract Instruments 107, 206 Starlims 103 Custom Biogenic Systems 111 Stirling Ultracold 415 Denator AB 116 Taylor-Wharton 301, 400 DNA Genotek 315a Tecan 217 ELPRO Services 200 Thermo Scientific 409 Fisher BioServices 405, 407 Titian Software 214 Fluidigm Corporation 115a, 214a TTP Labtech 207, 306 Fluidx Ltd. 410 TWD TradeWinds, Inc. 115 Freezerworks 202 Vaisala, Inc 414a Gas Cryo Systems 118 Wheaton 415a Greiner Bio-One 205

Platinum Partners Gold Partners

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Sign up for the 5K Fun Run/1M Walk/Sleep Walk Take part in the ISBER 5K Fun Run-walk or run at your own pace and help the ISBER Global Expansion Fund raise money for the ISBER Travel Award. Sign up online or at the registration desk on site. Thursday May 22, 06:30 – 07:30 Meeting Point: Dolphin Hotel Lobby, 06:00

Supporters:

inal Biotech dic As e so M c a ia in t i h o C n

B io 9 ba 00 nk Branch 2

inal Biotech dic As e so M c a ia n t i i h o n C Interactive Discussions B i 9 ob 00 an h 2 The Interactive Discussionsk Branc are composed of several focused roundtable discussions on topics submitted and coordinated by ISBER members. Sign up to participate in the discussion of your choice at the Registration Desk. Friday, May 22, 15:30 – 16:30 in Room Pacific C.

2014 Topics The Future of Sample Tracking Facilitator: Martin Frey Building Collaborations Between Biorepositories and Digital Repositories: Research Challenges and Research Benefits Facilitator: James W. McNally LMIC Discussion Group-ISBER 2014 Facilitator: Maimuna Mendy Best Practices in Bioprocessing and Biobanking to Support Biomarker Development Facilitator: Kristina Robson

Secondary Use of Human FFPE Samples. Do’s & Don’t’s Facilitator: Chantal Steegers

International Society for Biological and Environmental Repositories Genomic solutions for biobanks.

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See how we can work together by meeting with Illumina during ISBER. Contact Alem Taye at +1.301.828.5500. Join our workshop: Illumina Biobank Solutions Tuesday, May 20 at 16:00 Taylor-Wharton Partners for Life™

Submit this form at the link shown below with details on how you work to find a cure for Autism, and how this freezer could benefit the search for a cure.

http://partnersforlife.taylorwharton.com ISBER 2014 Scientific Program

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Exhibition Passport

120 120a 121 222 220 Name:

118 117 216 217 316 317 416 419

118a 115a 214a 215 314a 315a 414a 417

116a 415a

116 115 214 215a 314 315 414 415

114 113 212 213 312 313 412 413

112 111 211 310 410 411

110 409a

108 107 206 207 306 307 406 409

106 105 204 205 304 305 404 407

104 103 202 203 302 303 402 405

102 101 200 201 300 301 400 403

International Society for Biological and Environmental Repositories Fill it in and win! Win a Two-Night Stay at the Walt Disney Swan & Dolphin Resort

How to enter: Keep the Exhibitor’s Passport with you when you visit the Exhibit. Make sure that the Exhibitors stamp your passport as you visit their booths. Once you have completed the form, return it to the Registration Desk (You must have 55 stamps to be eligible). The draw will take place at the Business Meeting on Friday, May 23, 16:45 – 18:00.

21 Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Pre-Conference Workshops

Tuesday, May 20, 2014

06:45 – 17:30 Registration (Atlantic Hall Foyer) 07:00 – 13:00 Pre-Conference Workshops (separate registration required) 07:00 – 08:00 Coffee & Pastries (Europe Hall Foyer) Time Europe 9 Europe 10 Time Europe 11 Workshop 1A: Workshop 2A: Workshop 3A: “Fit for Purpose” Protocol Planning: A Implementing Robust Quality Part 1: Issues to Consider in Designing Tutorial to Facilitate Evidence Focused Management Systems for Repositories a Repository 07:00 – 08:30 Biobanking Practice - in Real Time Facilitators: Judith Giri, Elaine Gunter, Part 2: The Nuts and Bolts of 07:00 – 09:30 Facilitators: Lisa B. Miranda, Melissa Barbara Glazer, Phil Baird Operating a Repository Rawley-Payne, Helena Judge Ellis, Facilitators: Katherine Sexton, William Mark Bouzyk E. Grizzle 08:30 – 08.45 Coffee Break (Europe Hall Foyer) Workshop 1B: Workshop 2B: 09:30 – 09:45 Coffee Break (Europe Hall Foyer) Surveys, Migration, and Part 1: Biospecimen Science: Workshop 3B: Changes – Informatic Considerations Learning from Cryobiology to Improve Essential Concepts for Effective for Biobanks Preservation Outcome Specimen Receipt Facilitators: Kevin Meagher, Piper Facilitators: Rebecca Spindler, Mark Facilitators: Karen Pitt, Rebecca Pugh 08:45 – 10:45 Mullins, Ashok Patel, Mark Cada Cosentino, Erik Woods (Part of the educational requirements of the Part 2: Keep Your Samples Safe: 09:45 – 11:15 ISBER Certified Repository Technician program) Choose the Appropriate Storage Container Facilitator: Alexandra Lerch-Gaggl

10:45 – 11:00 Coffee Break (Europe Hall Foyer) Workshop 1C: Workshop 2C: 11:15 – 11:30 Coffee Break (Europe Hall Foyer) Are You Prepared? Case Studies in Limitations in the Use of Human and Workshop 3C: Balancing Biospecimen-related Patient Animal Tissues in Research: What Creating Successful Training Programs and Investigator Requests with Risk Biorepositories and Investigators Need for Repository Staff Management and Human Subjects to Know Facilitators: Karen Pitt, Alexandra 11:00 – 12:30 Protections in the Age of Genomic Facilitators: William E. Grizzle Medicine 11:30 – 13:00 Lerch-Gaggl Facilitators: Marianna Bledsoe, Mary (Part of the educational requirements of the ISBER Certified Repository Technician program) E. Edgerton, Ty Hoover, Nicole Sieffert

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

13:30 – 18:15 Corporate Workshops Time Europe 9 Europe 10 Europe 11 Workshop 1A Workshop 2A Workshop 3A Bytes and Biospecimens: Transforming Successful Implementation of Automation in Towards Successful Collaborative Translational your Biobank into a Knowledge-Base for Biobanks Research through Biobanking: Considerations Personalized Medicine Tecan US, Inc. for Managing Sample Temperature and 13:30 – 14:30 Biofortis Pre-analytical Variability Fisher BioServices

14:30 – 14:45 Coffee Break (Europe Hall Foyer) Workshop 3B Heat Stabilization Maintains Sample Integrity in Collection and Processing for Biobanking Denator AB 14:45 – 15:45

15:45 – 16:00 Coffee Break (Europe Hall Foyer) Workshop 1C Workshop 2C Workshop 3C Using Automated Storage to Meet Repository Biobank Solutions Protecting Your Biological Assets and Your Objectives Illumina Budget: Novel Strategies for Sample Archival Brooks Automation and Quality Assurance 16:00 – 17:00 Biomatrica

17:00 – 17:15 Coffee Break (Europe Hall Foyer) Workshop 1D Workshop 2D Workshop 3D Managing the Past for the Future Panasonic ISBER Best Practices & Storage Options TTP Labtech & CryoXtract Taylor-Wharton

17:15 – 18:15

Biopreservation and Biobanking Editorial Board Meeting (Invitation Only) 17:30 – 19:00 Oceanic 4

Reception for Chinese Delegates (Open to all delegates from China) Sponsored by Taylor-Wharton 19:00 – 21:00 Australia 2

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014 Scientific Program

Wednesday, May 21, 2014

07:00 – 18:00 Registration (Atlantic Hall Foyer) 07:00 – 08:00 Coffee & Pastries (Pacific A) 07:00 – 08:00 Working Group Meetings Time Europe 9 Europe 10 Europe 11 Biospecimen Science Working Group Environmental Biospecimens Hospital-Integrated Biorepositories 07:00 – 08:00 (Invitation Only) Working Group (Open to all Participants) Working Group (Open to all Participants) Getting to Know ISBER Meet and Greet for new and prospective ISBER members. All meeting participants welcome and encouraged to attend. 08:00 – 09:00 Chairpersons: Kathi Shea (USA), Elaine Gunter (USA) Pacific A Symposium 1 • Advancing Science Through Evidence-Based Biobanking Chairpersons: Jodi Black (USA), Marianne Henderson (USA) This symposium will focus on how high-quality samples, data and research support evidence-based discoveries in both global and environmental health, and inform evidence based best practices in biobanking. Pacific A 09:30 – 09:45 Welcome and Opening Remarks • Fay Betsou (Luxembourg) ISBER President, 2013-2014 09:30 – 12:30 Keynote Speaker: Integration of Biobanks into Clinical Health Care through Linkage to Medical Records—The 09:45 – 10:30 eMERGE Experience • Rex Chisholm (USA) 10:30 – 11:00 The Australian Plant Bank – Safeguarding Plants for the Future • John Siemon (Australia) 11:00 – 11:30 Coffee Break in Exhibit Hall 11:30 – 12:00 Geisinger’s MyCode Project: Leveraging Genomics and EMR Data to Improve Patient Outcomes • David Ledbetter (USA) 12:00 – 12:30 Cell Processing and Preservation for Biobanking: New Horizons • Erik Woods (USA) 12:30 – 14:00 General Lunch with Exhibits 12:30 – 13:30 Working Group / Advisory Committee Meetings Time Europe 9 Europe 10 Europe 11 Science Policy Committee Rare Diseases Working Group Membership & Marketing Committee 12:30 – 13:30 (Invitation Only) (Open to all Participants) (Invitation Only) Symposium 2 • Translational Science through Biobanking: Applications and Opportunities Chairpersons: Zisis Kozlakidis (UK), Brent Schacter (Canada) Translational research is necessary to find practical, research-based answers to important questions. It creates both new opportunities for further research and provides innovative feedback on relevant and critical issues in order to improve biobanking practices. This symposium will focus on practical solutions utilizing translational research approaches in many diverse fields in biobanking. Pacific A 14:00 – 16:30 14:00 – 14:30 Clonal Evolution and Breast Cancer Subtypes • Sam Aparicio (Canada) 14:30 – 15:00 Enabling Personalized Discovery and Translation • Hakim Djaballah (USA) 15:00 – 15:30 Translational Applications of Biobanking: The Fibroblast Growth Factor 23 Story • Myles Wolf (USA) 15:30 – 16:00 China National GeneBank, Making the Resource Valuable to Everyone • Yong Zhang (China) 16:00 – 16:30 China Biobanking Strategy for Integrated Translational Research • Rongxing Gan (China)

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

16:30 – 18:30 Welcome Reception Join us for an opportunity to network with attendees and exhibitors! Odd numbered posters will be on display. Exhibit Hall 18:30 – 19:30 Working Group / Advisory Committee Meetings Time Europe 9 Europe 10 Europe 11 Oceanic 4 Publications Committee Education & Training Rights to and Control of Integrated Biobanking (Invitation Only) Committee Human Tissue Samples Workflows Working Group 18:30 – 19:30 (Invitation Only) Working Group (Open to all Participants) (Open to all Participants)

Thursday, May 22, 2014

07:00 – 18:00 Registration (Atlantic Hall Foyer) ISBER 5K Fun Run/1M Walk/Sleep Walk (Separate Registration Required) Meeting point: Dolphin Lobby 06:00 06:30 – 07:30 Walk or run at your own pace and help the ISBER Global Expansion Fund raise money for the 2015 ISBER Travel Award. 07:30 – 08:30 Coffee & Pastries (Pacific A) Symposium 3A (Concurrent Session) Financial Sustainability of Biobanks Chairpersons: Marianne Henderson (USA), Daniel Simeon-Dubach (Switzerland) Financial sustainability in biobanking: moving past models to real world experiences in biobanks ranging from country-wide and regional networks, to large medical centers, to non-profit, to government. This session will be an INTERACTIVE AUDIENCE SESSION. Be early to get a keypad to register your views during this informative discussion. Support for the use of the audience participation toolset was generously sponsored by Dataworks Development. Biobanking is a key component of personalized medicine. The complexity of biobanking is increasing with the demands to improve specimen and data quality, scientific methodology, safety, operations, ethical and legal infrastructure. These improvements escalate the cost of the biobanking business across the continuum. Long term financial sustainability must be maintained to maximize the benefit of biobanking to global health. The need to sustain biobanking to support global health is a challenge of buy-in of all stakeholders; financial support from many different sources; and risk management. This interactive session will provide views from several biobanking experts and their in-process approach to sustainable operations. Pacific A Overview 08:30 – 11:30 08:30 – 08:40 Marianne Henderson (USA), Daniel Simeon-Dubach (Switzerland) 08:40 – 08:55 Peter Watson (Canada) 08:55 – 09:10 Brent Schacter (Canada) 09:10 – 09:25 Rusty Bromley (USA) 09:25 – 09:40 Brian Thomson (UK) 09:40 – 09:55 Peter Riegman (Netherlands) 09:55 – 10:30 Coffee Break in Exhibit Hall 10:30 – 10:45 Jan-Eric Litton (Sweden) Panel Discussion with Audience Participation 10:45 – 11:30 Panel: Peter Watson (Canada), Brent Schacter (Canada), Rusty Bromley (Canada), Brian Thomson (UK), Peter Riegman (Netherlands), Jan-Eric Litton (Austria), Jim Vaught (USA), Balwir Matharoo-Ball (UK)

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Symposium 3B (Concurrent Session) Model Organisms and Biodiverse Biorepositories: Interdisciplinary Perspectives in Biobanking (Joint Session with the Society for Cryobiology) Chairpersons: Piper Mullins (USA), Paul Bartels (South Africa) Research on model organisms and diverse species enhances knowledge of fundamental biological properties for biodiversity conservation, biotechnology development and human health. This symposium will focus on environmental and biological biobanks and how their operations contribute to interdisciplinary applications across biobanks. Pacific C From Concept to Application: Developing a Functional DNA and Germplasm Repository for Animal 08:30 – 09:00 Genetic Resources Harvey Blackburn (USA) 08:30 – 11:30 The Ins and Outs of a Living Bank: Prioritisation, Viable Populations and Continual Access 09:00 – 09:30 Rebecca Spindler (Australia) Keeping Clear of the Lions Mouth – Establishing & Scaling-up a Biodiversity Biobank for Southern Africa 09:30 – 10:00 Paul Bartels (South Africa) 10:00 – 10:30 Coffee Break in Exhibit Hall The International Environmental Specimen Bank (IESB) Group 10:30 – 11:00 Paul Becker (USA) The Endangered Species Challenge: Making Use of Opportunistic Sampling 11:00 – 11:30 Erin Ehmke (USA) Innovative Technologies Chairs: Andy Zaayenga (USA), David Lewandowski (USA) The Innovative Technologies session is a unique opportunity for companies to highlight the science and validation behind new products and technologies that have the potential to impact biorepository operations and specimen management/workflow. Pacific A 11:30 – 11:35 Welcome 11:35 – 11:45 Tissue Microarray Technology: New Opportunity for Tissue Banks to Contribute to Cancer Research and Diagnostics Pasquale De Blasio (USA) 11:45 – 11:55 New Metabolic Assay for Pre-Analytical Quality Control of Human Plasma Samples 11:30 – 12:30 Beate Kamlage (Germany) 11:55 – 12:05 The Fluidigm® SNPtrace™ Panel and the BioMark™ System Enable Fast, Efficient, and Cost-Effective Sample Assessment with Minimal Hands-On Time Marie Lee (USA) 12:00 – 12:15 Technologies to Fully Automate Biological Vapor-Phase Nitrogen Repositories Below -100°C Lutz Doms (Germany) 12:15 – 12:25 Rapid Heat Stabilization of Enzymes is Essential for Accurate Measurement of Tissue Sample Analytes without Interference from Post-Mortem Events Charlotta Göransson (Sweden) 12:25 – 12:30 Closing Remarks 12:30 – 14:00 General Lunch with Exhibits and Posters • Odd Numbered posters will be on display. Working Groups Meetings / Advisory Committee Meetings Europe 9 Europe 10 Europe 11 12:30 – 13:30 Biospecimen Science Working Group Proficiency Testing Advisory Group Management of Investigator-Returned (Open to all Participants) (Invitation Only) Research Results Special Interest Group (Open to all Participants)

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

Contributed Paper Session 1 (Concurrent Sessions) Contributed Paper Session 2 (Concurrent Sessions) Specimen Quality: Do you Know What you are Really ELSI for Biobanking – Is the Tail Wagging the Dog? Working With? Chairpersons: Sylvia Silver (USA), Rebekah Rasooly (USA) Chairs: Jane Carpenter (Australia), Galen Hostetter (USA) Pacific C Pacific A The Effect of Blood Shipping on the Survival Developing Best Practice Biobanking with 14:00 – 14:15 and Functionality of PBMCs 14:00 – 14:15 Indigenous Peoples Anita Posevitz-Fejfár (Germany) Maui Hudson (New Zealand)

Developing Mouse Hospital with Human Future Use Considerations for Global Collec- tions of Human Biospecimens: Annotation Patient Derived Xenograft Cancer Models – 14:15 – 14:30 14:15 – 14:30 to Ensure Compliance in an Evolving Global A Live Tumor Banking Approach Regulatory Environment Vinagolu Rajasekhar (USA) Katheryn Shea (USA) Biobanking of Human Kidney Cancer Tissue: Senior Biobank Staff and Genetic Researchers’ Impact of Ex-Vivo Ischemia Time and Storage Opinions about Human Subjects Practices in 14:30 – 14:45 14:30 – 14:45 Time on RNA Quality Genomic Research Xianling Cong (China) Rachel Dvoskin (USA) 14:00 –16:00 Next Generation BioSpecimen Sciences at EU Data Protection Regulation and University Health Network – Canada’s Largest 14:45 – 15:00 14:45 – 15:00 Transatlantic Datasharing Hospital-Based Research Program Evert-Ben van Veen (The Netherlands) Michael Roehrl (Canada) Tissue Modeling of RNA Degradation: Multi- Genetic Knowledge and Return of Results Modality Measures and Biological Pathway 15:00 – 15:15 15:00 – 15:15 Preferences in the Mayo Clinic Biobank Correlates Janet Olson (USA) Galen Hostetter (USA) Gene Expression Assay to Assess the Omics-Ready Bio/Data Repository For 15:15 – 15:30 Pre-Centrifugation Delay of PBMCs 15:15 – 15:30 Childhood Cancers in Egypt Olga Kofanova (Luxembourg) Rania Labib (Egypt) Role of the Genetic Counselor in a Non- Storage Stability of Metabolic Diseases Disease Focused Biobank: Experience of the 15:30 – 15:45 Biomarkers in Urine 15:30 – 15:45 Mayo Clinic Biobank Yinan Zhang (China) Erin Winkler (USA) 15:45 – 16:00 Discussion 15:45 – 16:00 Discussion Exhibitor and Poster Networking Evening 16:00 – 18:00 Join us for a networking event to visit the exhibits and posters! Even numbered Posters will be on display.

Friday, May 23, 2014

07:00 – 18:00 Registration (Atlantic Hall Foyer) 07:00 – 07:30 Vendor Meeting (All exhibitors are encouraged to particpate) Facilitator: David Lewandowski Australia 3 07:30 – 08:30 Coffee & Pastries (Pacific A) Working Group Meetings Europe 9 Europe 10 Europe 11 07:30 – 08:30 Informatics Working Group Regulatory and Ethics Working Group International Repository Locator (Open to all Participants) (Open to all Participants) Working Group (Open to all Participants)

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Symposium 4 • Biospecimen Science (Joint Session with the Society for Cryobiology) Chairpersons: Olga Kofanova (Luxembourg), Jason Acker (Canada) This symposium will introduce new discoveries and challenges of biospecimen science and raise awareness of issues influencing sample integrity related to different biopreservation steps, including freezing and storage. The goal of this symposium will be to cover pre-analytical aspects in handling and analysis of specimens, and the application of cryobiological principles to the successful preservation of biospecimens and biological resources. Pacific A Controlled Analysis of Pre-Analytical Variables in CSF 2 Blood Sample Collection, Processing & Storage: 08:30 –09:00 08:30 – 11:30 Implications for Best Practices in Clinical Research • Mimi Roy (USA) 09:00 – 09:30 Scientific Basis for Selection of a Storage Temperature • Alison Hubel (USA) 09:30 – 10:00 Markers of Biobank Sample Quality • Rainer Lehman (Germany) 10:00 – 10:30 Coffee Break in Exhibit Hall 10:30 – 11:00 The Science of Freezing Blood Cells • Jason Acker (Canada) 11:00 – 11:30 Understanding Biospecimen Sample Integrity Using Molecular and Proteomic Biomarkers • Lokesh Agrawal (USA) 11:30 – 13:00 General Lunch with Exhibits and Posters • Even numbered Posters will be on display. Contributed Paper Session 3 (Concurrent Sessions) Contributed Paper Session 4 (Concurrent Sessions) It’s a Small World: Are We Preserving It? Through the Looking Glass: Hot Topics in Biobanking Chairs: Koh Furuta (Japan), Heather Siefers (USA) Chairs: Zisis Kozlakidis (UK), Maimuna Mendy (France) Pacific A Pacific C Organization of the Seed Bank in the Biobank Graz: Accumulative Hub of 13:00 – 13:15 Permafrost Soils of the Yakutia 13:00 – 13:15 Biobanking Networks in Europe Efim Khlebnyy (Russia) Karine Sargsyan (Austria) Using the Biomaterial of the Radiobiological Influence of Permafrost on Allium Human Tissue Repository for Solving the 13:15 – 13:30 Fistulosum Seeds Preservation 13:15 – 13:30 Problems of Radiobiology Ilya Prokopiev (Russia) Evgeniya Kirillova (Russia) Biobank Construction after Earthquake and The Value of Large Scale Biobanking in 13:30 – 13:45 Tsunami Disaster in Japan 13:30 – 13:45 Clinical Healthcare Naoko Minegishi (Japan) Gyorgy Marko-Varga (Sweden) The Great Lakes Biorepository Research Network (GLBRN) – An Inter-Institutional China National GeneBank (CNGB) Status Collaborative Effort to Improve the 13:00 – 15:00 13:45 – 14:00 Quo as of the End of 2013 13:45 – 14:00 Management of Biospecimen Collections Tina Yeung (China) and Subsequent Translational Research Jan Akervall (USA) Towards the Use of Mobile Lab The Dutch National Tissuebank Portal. One Technologies for the Collection of Human Portal to All Pathology Archives 14:00 – 14:15 Samples of the German Environmental 14:00 – 14:15 Chantal Steegers (The Netherlands) Specimen Bank Dominik Lermen (Germany) Dynamic Map-Based Visualization Tools for Marine Environmental Specimen Bank Complex Inventory/Freezer Management: 14:15 – 14:30 Barcode Implementation System 14:15 – 14:30 Open Source Informatics Developed by Amanda Moors (USA) NHLBI BioLINCC Elizabeth Wagner (USA) Financial Sustainability in Biobanking 14:30 – 14:45 Discussion 14:30 – 14:45 is a Myth Monique Albert (Canada) 14:45 – 15:00 Discussion 15:00 – 15:30 Coffee Break in Exhibit Hall

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

Special Topic Session (Concurrent Sessions) Interactive Discussions Important Biobanking Developments in Europe All the discussions take place concurrently. Chairpersons: Fay Betsou (Luxembourg), Rita Lawlor (Italy) Pacific C Pacific A 15:30 – 15:40 Introduction The Future of Sample Tracking Fay Betsou (Luxembourg) & Rita Lawlor (Italy) Facilitator: Martin Frey (USA) 15:40 – 16:10 BBMRI-ERIC, a New Governance Tool Building Collaborations Between Biorepositories and Digital for Biobanking Repositories: Research Challenges and Research Benefits 15:30 – 16:30 Jan-Eric Litton (Sweden) Facilitator: James W. McNally (USA) 16:10 – 16:30 The Finnish Law on Biobanks and the LMIC Discussion Group-ISBER 14 EU General Data Protection Regulation Facilitator: Maimuna Mendy (France) Proposal: How to Compose Different Approaches within the European Ethical Secondary Use of Human FFPE Samples. Do’s & Don’t’s Landscape? Facilitator: Chantal Steegers (The Netherlands) Elena Salvaterra (Italy) Best Practices in Bioprocessing and Biobanking to Support Biomarker Development Facilitator: Kristina Robson (USA) ISBER Business Meeting and Awards Presentation 16:45 – 18:00 Join us to learn more about ISBER’s activities, financials, strategic plan and leadership Pacific A 18:30 – 19:30 Working Group / Advisory Committee Meetings Time Europe 9 Europe 10 Europe 11 18:30 – 19:30 Trans-Omics Working Group Automated Repositories Working Governance Committee (Open to all Participants) Group (Open to all Participants) (Invitation Only)

Saturday, May 24, 2014

07:00 – 13:00 Registration (Atlantic Hall Foyer) 07:30 – 08:30 Coffee & Pastries (Pacific A & B) 2014 Education & Training Workshops 08:30 – 09:30 Hell or High Water: The Alberta Cancer Research Biorepository Disaster Readiness, Response and Recovery (Workshop 1A) Facilitators: Nigel Brockton (Canada), Charlene Karvonen (Canada) Pacific A Informed Consent for Genomics: Policies, Problems and Practical Approaches (Workshop 1B) 08:30 – 09:30 Facilitators: Marianna Bledsoe (USA), Amelia Warner (USA), Anita Nelsen (USA) Pacific C 09:30 – 09:45 Coffee Break Weathering the Storm: Assessing Business Continuity Measures in Biorepository Operations (Workshop 2A) 09:45 – 10:45 Facilitators: Kristina Robson (USA), Andrew Brooks (USA) Pacific A ELSI Challenges in Biobanking & Genomics Research (Workshop 2B) 09:45 – 10:45 Facilitators: Pedro Rondot Radío (Argentina), Rosario Isasi (Canada), Anne-Marie Tassé (Canada) Pacific C 10:45 – 11:00 Coffee Break (Pacific A)

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Symposium 5 • Biospecimen Identifiability, Privacy and Broad Data Sharing Chairpersons: Marianna Bledsoe (USA) and Kristen B. Rosati (USA) A number of recent studies have raised questions about the identifiability of “de-identified” genomic data and specimens and about how best to protect the privacy of participants and the confidentiality of their data. At the same time, broad sharing of genomic information and individual- level data is not only being encouraged but, in some cases, required. The tension between the need to protect privacy and the need to share data broadly to facilitate scientific and medical advances raises a number of policy challenges. This symposium will explore these issues and ways they might best be addressed through policy and law. Pacific A 11:00 – 13:00 11:00 – 11:20 Assessing and Mitigating Risk of Identifiability Brad Malin (USA) 11:20 – 11:40 Recent EMA Regulations Mandating Clinical Trials Data Sharing Mark Barnes (USA) 11:40 – 12:00 Building an International Code of Conduct for Genomic and Health-Related Data Sharing Anne-Marie Tassé (Canada) 12:00 – 13:00 Panel Discussion Panel: Tim Shi (China), Tohru Masui (Japan), Brad Malin (USA), Mark Barnes (USA), Anne-Marie Tassé (Canada), Evert-Ben van Veen (The Netherlands), Helen Morrin (New Zealand), Amelia Warner (USA)

International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program

Speaker Summaries Recent EMA Regulations Mandating Clinical Trials Data Sharing The Science of Freezing Blood Cells Mark Barnes, J.D., Ropes & Grey, Boston, USA Jason Acker MBA, PhD, Canadian Blood Services, Edmonton, Canada EMA has recently begun to require that patient-level data collected in the course Cryopreservation of cells is an integral function of cell processing laboratories of clinical trials and that support any successful marketing application submitted and biorepositories. Yet many who routinely perform cell cryopreservation have to EMA must be made available in an anonymized form to independent limited knowledge about cryobiology, the mechanism of action of cryoprotective researchers. Meanwhile, the EU has also tightened its various privacy agents, the impact of cryoinjury on post-thaw cell quality measures, and the regulations, which seems, in spirit if not in law, to be inconsistent with EMA’s impact that damaged and dead cells can have on patients upon infusion. This push for data transparency. This session will explore EMA’s regulations and the presentation will be focused on the cryopreservation fundamentals and their latest developments in EU privacy law, to understand these requirements, and influence on common practices as well as quality control aspects of the freezing how they relate to clinical trials in North America and around the world. process and the biophysics of transient warming events. The cryopreservation of human blood cells will be used to illustrate the multiple factors that need to be The International Environmental Specimen Bank (IESB) considered when developing cryopreservation protocols for cellular therapeutics Group or archived cellular materials. Paul Becker, Chemical Sciences Division, National Institute of Standards & Technology, Charleston, United States Understanding Biospecimen Sample Integrity Using Environmental specimen banking has been recognized worldwide as an important Molecular and Proteomic Biomarkers component to real time environmental monitoring, such as environmental Lokesh Agrawal, PhD, Biorepositories and Biospecimen Research Branch, DCTD, contaminants. Since the 1960’s scientists have been collecting and archiving National Cancer Institute, Rockville, USA environmental specimens (i.e. biological tissue, sediment, seeds, ice cores, etc.) The talk will summarize research projects sponsored by the NCI Biospecimen for these types of analytical analyses. The International Environmental Specimen Research Network (BRN) to develop assays and identify biomarkers that may Bank (IESB) Group has been exchanging data, protocols, and strategies of be used as sentinel markers of plasma and tissue stability in biobanks using environmental specimen banking for over 30 years. The IESB Group will be mass-spectroscopy proteomics, analysis of circulating miRNA, and development described in more detail, including approaches being considered for enhancing of intrinsic controls for FFPE tissues. Protein biomarkers for assessing sample international cooperation and the potential relationship between it and ISBER. integrity in plasma will be discussed followed by a second project looking at the effects of pre-analytical variables on circulating miRNA for identification From Concept to Application: Developing a Functional and validation of new housekeeping. Another study will describe a series of DNA and Germplasm Repository for Animal Genetic biomarkers identified and validated using construction of tissue microarray Resources (TMA) and tissue quality index (TQI). New projects that involve comparison of proteome in plasma and PBMCs taken from patients before and after Harvey Blackburn, PhD, USDA/ ARS/ National Animal Germplasm Program, Fort administration of general anesthetic, and stability of phosphoproteins in colon Collins, USA tumor and normal adjacent tissues with respect to processing and surgical In 1999 USDA’s Agricultural Research Service initiated the development of the manipulation will also be discussed. Overall this presentation will outline the National Animal Germplasm Program for the protection and increased utilization progressive efforts taken by BRN-sponsored projects to define the impact of of livestock genetic resources. The primary mechanism to accomplish this goal key pre-analytical variables in human biospecimens and to develop innovative has been the development of cryopreserved collections of germplasm and tissue approaches for assessment of biospecimen quality. from all major livestock and aquatic species. Since its inception this program has released over 15,000 samples to the public and private sector for animal regeneration or genomic studies. The current status and future development of Clonal Evolution and Breast Cancer Subtypes this collection will be the subject of the presentation. Sam Aparicio BM, BCh, PhD, FRCPath, BC Cancer Agency, Vancouver, Canada The notion that most cancers are ecosystems of evolving clones has implications Integration of Biobanks into Clinical Health Care for biological understanding and clinical application. The evolution of clonal through Linkage to Medical Records—The eMERGE composition has particular significance when evidence of positive or negative Experience selection can be associated with the clonal genotype or epigenotype. I will Rex Chisholm, PhD, Northwestern University, Chicago, USA discuss the implications of clonal evolution for cancer medicine, with reference to breast cancer subtypes. We have developed informatics approaches to The NUgene biobank links consented participants DNA samples with the population-level clonal analysis and extended these to single cell genotypes. totality of clinical information collected from their electronic health records Our more recent data on clonal evolution of patient-derived tumour xenografts sources obtained during routine clinical care. This resource is being used in illustrates the impact of clonal evolution on biological studies of cancer. discovery projects to identify novel gene/variant associations with disease susceptibility and the outcomes of therapies. This presentation will describe the experience of NUgene and the eMERGE consortium in both discovery and

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

in the implementation of genomic medicine through association of genetic medicine led to creation of the MyCode biobank in 2006 to enable longitudinal, variation with the clinical record, development of clinical decision support and genomic medicine translational research. Strengths of MyCode include a stable assessment of the outcomes. population, multi-generational families, a single, dominant healthcare provider system, searchable medical data from ~20 years of EHR, and a participant Enabling Personalized Discovery and Translation consent rate of >90%. Recent enhancements to the MyCode consent and Hakim Djaballah, PhD, Director, Memorial Sloan-Kettering Cancer Center, New protocol to enable whole exome sequencing of 100,000 participants and the York, USA return of clinically actionable findings to participants will be discussed. One of the biggest challenges in treating cancer patients today is, and will Markers of Biobank Sample Quality be, the choice of drug regimen to administer and its consequences on disease remission and/or relapse. Advances in screening technologies combined with Rainer Lehmann PhD, University of Tübingen, Tübingen, Germany rapid purification and characterization of primary patient cancer cells, though The number of biobanks storing human body fluids is rapidly increasing world very amenable to hematopoietic malignancies, would permit drug assessment wide. This offers promising perspectives for large-scale epidemiological studies of prior to treatment in a precision strategy lineup of regimens. I will present and common diseases to develop novel prevention and/or treatment strategies. Great discuss the strategy and its use in the clinic. efforts are undertaken to generate high quality samples. But accidental as well as systematic pre-analytical errors in the sample processing can not be excluded, The Endangered Species Challenge: Making Use of even under very strictly controlled conditions. However, up to the present there is Opportunistic Sampling no way to assess the quality of blood samples stored in a biobank. Erin Ehmke, PhD, Duke Lemur Center, USA In this talk, robust biomarkers of biobank blood sample quality, identified by How can endangered species be utilized by the research community and, in a pseudotargeted metabolomics approach, are presented. The changes of the particular, the biomedical field? The Duke Lemur Center (DLC) present a case plasma concentration of these biomarkers in extreme (patho)physiological study demonstrating the utility of the opportunistically banked samples inventory situations, like reanimation, hepatic failure, exhaustive exercise are also and associated database information, highlighting the solid foundation on demonstrated. In addition, common pre-analytical pitfalls potentially affecting which a wide variety of future biological studies can be built. the outcome of large-scale epidemiological studies, and how to avoid these, will be discussed. China Biobanking Strategy for Integrated Translational Research BBMRI-ERIC, a New Governance Tool for Biobanking Rongxing Gan, MD, Shanghai Clinical Research Center, Shanghai, China Jan-Eric Litton, MD, Director General, BBMRI-ERIC, Stockholm, Sweden As precious resource for both basic and clinical research, biobanks are the On December 3rd, 2013, BBMRI was officially awarded the Community legal basis of translational research. High quality biosamples and data are crucial for framework for a European Research Infrastructure Consortium (ERIC). This biobanking. With the rapid development of biobanking in the past years, it has specific legal form is designed to facilitate the joint establishment and operation been the priority for health research in China. China National Biobank initiative of research infrastructures of European interest. The ERIC status allows pulling has been planned for developing a nation-wide network of biobanks with together biobanks and biomolecular resources into a pan-European facility. unified standards and an information sharing system for the clinical resource BBMRI-ERIC will provide access to the collections of partner biobanks and database with focus on high quality biosamples and data, which will better biomolecular resources, their expertise and services on a non-economic basis. serve new drug development and translational research in the future. The China Within the platform, research groups can develop functional standards for Biobanking Strategy has drawn up the roadmap and provides suggestions for technical, legal and ethical purposes, set up criteria for biobanks, and so on. the development of biobanking in China. The ERIC also creates a platform for the involved researchers to communicate with policymakers in the EU and the Member States. BBMRI-ERIC will be a Scientific Basis for Selection of a Storage Temperature distributed infrastructure. Allison Hubel, PhD, University of Minnesota, Minneapolis, USA Austria, Belgium, Czech Republic, Estonia, France, Germany, Finland, Greece, The stability of a biospecimen is strongly influenced by storage conditions. This Italy, Malta, the Netherlands and Sweden are members of BBMRI-ERIC. talk will describe the manner by which freezing conditions, solution composition Observers are Switzerland, Norway, Poland, Turkey and IARC (International and deactivation of degradative molecules influence selection of storage Agency for Research on Cancer). The Office will be based in Graz, Austria with temperature. In addition, the scientific literature relevant to biospecimen Prof. Jan-Eric Litton as the Director General. storage will also be reviewed. Assessing and Mitigating Risk of Identifiability Geisinger’s MyCode Project: Leveraging Genomics and Brad Malin, PhD, Vanderbilt University, Nashville, USA EMR Data to Improve Patient Outcomes This presentation will review how biospecimens, and the data associated with David Ledbetter, PhD, Geisinger Health System, Danville, USA them, can be compromised to ascertain the identity of the individuals to which Geisinger is a “Learning Healthcare Laboratory” dedicated to improving patient they correspond. It will then review the difference between what is possible outcomes while reducing total cost of care. A commitment to personalized versus what is probable and how risk of identification can be formally assessed.

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

This presentation will conclude with a discussion on how such risk can be The Ins and Outs of a Living Bank: Prioritisation, mitigated using a combination of social and technical controls, with examples Viable Populations and Continual Access drawn upon several biorepositories the speaker has been involved with. Rebecca Spindler, PhD, Research and Conservation, Taronga Conservation Society, Controlled Analysis of Pre-Analytical Variables in CSF Sydney, Australia 2 Blood Sample Collection, Processing & Storage: The traditional concept of a static biobank that stores genetic material as insurance against a catastrophe is out-dated and must be reviewed. We are in Implications for Best Practices in Clinical Research the 6th global major extinction event, we are losing species at unprecedented Mimi Roy, PhD, Caprion Proteomics, Menlo Park, USA rates and few catastrophes were recognised. Our skills, research focus and Biological sample collection, processing and storage protocols are based on resources must now be targeted to capture viable genetic material from priority accepted practices rather than careful testing. We set out to examine variables species, incorporating minimum population sizes, availability of material for intrinsic to each step in obtaining and storing clinical samples, beginning research and novel techniques such as accelerated evolution. with collection in controlled studies. Blood and plasma/serum samples were The potential outcomes of strategic genome resource banks include: 1) compared before and after centrifugation. Various blood collection tubes, times preservation of gene diversity; 2) avoiding natural loss of heterozygosity due on bench, incubation temperatures, freeze-thaw cycles and freezer storage to genetic drift in shrinking populations; 3) identify and propagate resilient effects over 18 months were compared. Independent studies have verified individuals and genes throughout the population without losing overall genetic that these proteins indeed are markers of sample integrity. The results provide diversity; and 4) incorporate the study and use of reproduction, adaptation and extensive information on pre-analytical variables and clear guidelines for sample resilience to prevent species extinctions. handling for proteomic analysis. Building an International Code of Conduct for The Finnish Law on Biobanks and the EU General Data Genomic and Health-Related Data Sharing Protection Regulation Proposal: How to Compose Anne-Marie Tassé, Public Population Project in Genomics and Society (P3G) Different Approaches within the European Ethical Both an aspirational and practical instrument, the International Code of Landscape? Conduct for Genomic and Health-Related Data Sharing has been developed in collaboration with many international organizations such as the GA4GH, P3G, Elena Salvaterra J.D., PhD, Unit of Bioethics, Scientific Institute E. Medea, Italy BioSHaRE-EU, H3A, ICGC, INSERM, and IRDiRC. Founded on a human rights This talk aims to summarize interesting aspects of the European ethical framework (namely right to the benefits of science; right of attribution; and right landscape governing human biobanks. By focusing on relevant elements of the of scientific freedom) and based on the premise that such data sharing has been new Finnish Law on biobanks and the proposal of a European Regulation on approved and consented to, the Code considers international data sharing to be General Data Protection, it seeks to give a picture of the variable regulatory both a scientific and social benefit, and responds to the new challenges raised realm characterizing the Europe at present. Whereas the Finnish Law on by international, collaborative research. biobanks supports an ethically “open” approach to the research using human biological materials, by authorizing an “opt-out” consent model, the proposal Translational Applications of Biobanking: The of a harmonized European regulation on General Data Protection tends to Fibroblast Growth Factor 23 Story sustain restrictive measures to protect the privacy of data subjects in several Myles Wolf MD, MMSc , Northwestern University, Chicago, USA fields of life, including the scientific research environment. How to interpret this “fluidity” and compose this variable regulatory landscape in and out of Europe Abnormal regulation of fibroblast growth factor 23 (FGF23) was originally is the basic question of this presentation open to all the stakeholders involved discovered as the cause of rare hereditary forms of hypophosphatemic rickets. in biobank based research. This presentation will review how biobanked specimens from several large cohorts were used to transition FGF23 from molecular mechanism of rare The Australian Plant Bank – Safeguarding Plants for Mendelian diseases to emerging, mainstream risk factor for cardiovascular the Future disease, kidney disease progression and death. John Siemon, BSc, The Royal Botanic Gardens & Domain Trust, Mount Annon, Cell Processing and Preservation for Biobanking: Australia New Horizons Australia is home to 25,000 known species of plants, 80% endemic, but sadly 1,700 plant species and communities are threatened and at the brink of extinction. The Erik Woods PhD, Cook General BioTechnology, Indiannapolis, USA Royal Botanic Gardens Sydney is applying transdisciplinary conservation solutions As preservation of living cells becomes a critical need of biorepositories, a look to conserve species through the Australian PlantBank. PlantBank currently stores back at methods for processing, transporting and storage becomes paramount. 25 percent of Australia’s flora in seed form as well as living collections such as Lessons learned from cryobiology can become valuable tools new horizons tissue cultures and orchid mycorrhizal fungi. In the future, PlantBank will also in biobanking. house collections of fern spores and other potential regenerative entities. As a national repository PlantBank will one day research and store Australia’s entire native flora with capacity for collections from the Asia-Pacific region.

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

China National GeneBank, Making the Resource maintained to maximize the benefit of biobanking to global health. The Valuable to Everyone need to sustain biobanking to support global health is a challenge of buy- in of all stakeholders; financial support from many different sources; and Yong Zhang, PhD, China National GeneBank, Shenzhen, China risk management. This interactive session will provide views from several China National GeneBank is aiming to store 30 million samples and 500PB biobanking experts and their in-process approach to sustainable operations. data. It will contain human and non-human resource. With the coming This session encourages audience participation through interaction with sequencing technologies, we have series solutions (very low cost) where the moderators who will pose questions to the audience through handheld we could collaborate with all the other biobank for a new biobank era: polling tool and a panel discussion. Please come and participate! digitalization of biobanks and AppStore of biobanks. The Alliance will also help people both in scientific world and industrial world. As one of ISBER Moderators: Dr. Peter Watson, Director of the Tumour Tissue Repository at the British Columbia, Cancer Agency, Canada, Dr. Brent Schacter, Professor in the Department working group, we are putting lots of effort to education, training, etc. We of Internal Medicine of the University of Manitoba and member of the Department believe that we should together provide a universal platform and let all of Medical Oncology and Hematology at CancerCare Manitoba, Canada, Mr. Rusty biobanks, researchers, and industrial people working together. Bromley, Chairman of the Board, Vascular Cures, A non-profit foundation dedicated to developing new treatments and cures for vascular disease. Redwood City, California, Financial Sustainability in Biobanking: Moving Past USA, Dr. Brian Thomson, Associate Professor and Honorary Consultant, Nottingham Models to Real World Experiences in Biobanks Ranging University, United Kingdom, Dr. Peter Riegman, Head of the Erasmus MC Tissue Research Support Unit which includes the Erasmus MC Tissue Bank. Rotterdam, from Country-Wide and Regional Networks, to Large The Netherlands, Dr. Jan-Eric Litton, Director General of BBMRI-ERIC, Graz, Austria Medical Centers, to Non-Profit, to Government and Professor, Department of Medical Epidemiology and Biostatistics, Karolinska Biobanking is a key component of personalized medicine. The complexity Institutet, Stockholm, Sweden, Dr. Jim Vaught, Independent consultant and Editor-in- of biobanking is increasing with the demands to improve specimen and Chief at Biopreservation & Biobanking, a Mary Ann Liebert, Inc. publication and the data quality, scientific methodology, safety, operations, ethical and legal official journal ofI SBER, Kensington, MD, USA, Dr. Balwir Matharoo-Ball, Operations Manager for Translational Research and Nottingham Health Science Biobank, David infrastructure. These improvements escalate the cost of the biobanking Evans Medical Research Centre, Nottingham, UK business across the continuum. Long term financial sustainability must be ISBER Education and Training Workshop Summaries (separate registration required)

Tuesday May 20, 2014

Workshop 1A • 07:00 – 08:30 »» Biospecimen lifecycle and process chain quality requirements »» Overview of indirect and direct QC measures “Fit for Purpose” Protocol Planning: A Tutorial to »» Biobanking related outcome measures Facilitate Evidence Focused Biobanking Practice – in • Obtain real time guidance on FFP and EBBP Protocol development/ Real Time Audit readiness Facilitators: Lisa B. Miranda, Melissa Rawley-Payne, MA, Helena Judge Ellis, Mark • Acquire peer and biobank community feedback on relevant additions to Bouzyk, PhD the fit for purpose protocol development framework This workshop will increase the attendees’ knowledge base regarding evidence- based biobanking, specifically related to development of “fit for purpose” Workshop 1B • 08:45 – 10:45 sample management protocols. Attendees will actively participate in a presentation of a “fit for purpose” protocol planning exercise. Guidance will Surveys, Migration, and Changes – Informatic be offered in tandem with substantive audience discussion around relevant use Considerations for Biobanks cases. The workshop will enable attendees to obtain and share feedback with Facilitators: Kevin Meagher, Piper Mullins, MSc, Ashok Patel, MD, Mark Cada peers aimed at increasing understanding and consensus of opinion regarding factors for selection of quality control parameters, crucial considerations for This workshop will provide an overview of essential topics when choosing a evidence based sample management practices and technical requirements to new or migrating to a different inventory management system (i.e. specimen enable “fit for purpose” readiness of their current biobanking operations. database). Repositories use an inventory management system to track specimen locations, acquisitions, history, usage, and loans; provide metadata related to Objectives: the sampled subject; and share data with other research communities. Choosing and implementing an information management system is essential to successful • Increased understanding of the following concepts and related requirements repository workflow. Without accurate information about the specimens in the »» Evidence based biobanking and fit for purpose; repository and their associated data, the effort to find, retrieve, and maintain

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

the collection can become an overwhelming task requiring significantly greater Workshop 2A • 07:00 – 08:30 manpower resources. Presenters will discuss best practices for managing change in the biobank’s informatics infrastructure, migrating legacy data to Implementing Robust Quality Management Systems new systems, and linking specimen data to other data sources such as EMR’s or for Repositories organizational catalogs. Facilitators: Judith Giri, PhD, Elaine Gunter, MT (ASCP), Barbara Glazer, MT This workshop will also highlight data sharing considerations for information (ASCP), Phil Baird, MS management systems, and will discuss open access catalogs and minimum required metadata / database fields. Significant ISBER research is publicly A comprehensive quality management (QMS) is needed to ensure the consistent, funded with requirements to make the specimen information publicly available, optimal operations of a repository, in order to preserve the integrity and future value and this session will educate participants on setting up their databases to meet of specimens. The workshop will address the essential elements of a QMS, resources those requirements. needed and ensuring that written protocols are consistently practiced and monitored. The workshop will address practical topics including among others: development The workshop will also review ISBER IT Best Practices as well as results of the of written standard operating procedures, preparing for inspections, ensuring the 2013 IWG survey. integrity of inventory data, facility management and training of repository staff, and promoting continued quality improvements. The information presented will Objectives: complement ISBER Best Practice Guidelines, with specific details and QMS models. This workshop is offered by the Informatics Working Group in an effort to share our experiences and best practices with information management systems and Objectives repository databases. We will provide a “hands-on” session to explain in lay terms • Gain a greater appreciation of the need for strong quality management the importance of implementing well-designed databases with specific metadata. systems (QMS) for repositories Participants from non-informatics background will gain understanding of 1) • Provide practical guidance for developing and implementing the main best practices for implementing or migrating information systems for choosing components of a QMS, to complement ISBER Best Practice Guidelines new inventory software systems, especially during the repository design phase, 2) considerations for pushing data to public catalogs, and 3) an increased Workshop 2B • 08:45 – 10:45 awareness about the importance of Informatics in biobank operations. Part 1: Biospecimen Science: Learning from Workshop 1C • 11:00 – 12:30 Cryobiology to Improve Preservation Outcome Facilitators: Rebecca Spindler, PhD, Mark Cosentino, PhD, Erik Woods, PhD Are You Prepared? Case Studies in Balancing This workshop is jointly sponsored by ISBER and Society for Cryobiology (SFC). Biospecimen-related Patient and Investigator The workshop is intended to cover fundamentals of preservation including steps Requests with Risk Management and Human Subjects that are critical to favorable outcome. In addition, a discussion of practical hints Protections in the Age of Genomic Medicine and tips for individuals involved in preservation or supervising those involved Facilitators: Marianna Bledsoe, MA, Mary E. Edgerton, MD, PhD, Ty Hoover, MD, in preservation. Finally, factors that influence stability of biospecimens in long- JD, Nicole Sieffert term storage will be discussed. Case studies of increasingly complex recurring events that years ago were Part 2: Keep Your Samples Safe: Choose the unheard of, but are becoming increasingly frequent at institutions of various Appropriate Storage Container sizes, will be presented and discussed including, but not limited to: Facilitator: Alexandra Lerch-Gaggl, PhD • Patient requests for tissue procurement and distribution services »» With little or no notice The choice of the optimal storage container for a biological sample seems minimal »» To questionable recipients compared to the multitude of steps, which are involved in preparing samples for »» Without specific instructions, supplies, appropriate authorization long-term storage, but it is a crucial one. Different sample types might need • Departing investigator desire for specimen transfer different container vessels in order to keep specimens safe and intact. • Donor desire to direct biospecimen distribution at will • How data plays into these scenarios – What should be recorded? How? Objectives When should it be shared? With whom? • Identify variables, which influence the quality of their specimens • Concerns include but are not limited to: • Describe pros & cons of various storage containers »» Patient, Investigator and Institutional protection • Describe factors, which help guarantee reproducible sample identification »» Ethical concerns regarding denial of patient requests vs. patient protection »» The increasingly blurry line between clinical and research activity »» Increasingly difficult data management and biospecimen tracking

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Workshop 2C • 11:00 – 12:30 • Gain a better understanding about the legal, ethical, and regulatory issues that may affect the repository Limitations in the Use of Human and Animal Tissues • Understand the “nuts and bolts” of operating a repository in Research: What Biorepositories and Investigators • Identify space and resources needed to begin a repository Need to Know Workshop 3B • 09:45 – 11:15 Facilitator: William E. Grizzle, MD, PhD Biorepositories collect, process, store and distribute tissues to support a wide Essential concepts for effective specimen receipt range of research. This presentation will discuss the limitations in supporting Facilitators: Karen Pitt, PhD, Rebecca Pugh, MS biomedical research due to specific variables affecting tissues. Topics include the effects on research of 1) of heterogeneity of solid tissues, 2) fixation, alternate This workshop will teach participants to describe and establish effective forms of fixation, and processing of tissues to paraffin, 3) storage conditions processes for receiving a broad range of specimen types (e.g., human, non- of frozen tissue, paraffin slides, and paraffin blocks, 4) surgical variables (e.g., human, museum, etc.) into a biorepository. The topics covered will range warm ischemia, cautery artifacts, and cold ischemia), 5) sources of bias, and 6) from communications with the entity sending the specimens, ensuring the use of a quality management system (QMS) to improve the usefulness of tissues proper storage environments are available within the repository, evaluating for research. the condition of the specimens upon receipt, addressing discrepancies, and tracking the specimens from the time of delivery until they are transferred to Objectives: their temporary and more extended storage locations. To introduce the concept of differences in pre-analytical variables and potential Objectives: effects on research. • Describe the process by which specimens are received at the repository, • To present how bias arises due to differences in the collection, processing, inspected and prepared for interim or long term storage. storing and distribution of tissues. • Describe how information about compromised specimens is entered • To describe how QMS improves the quality of tissue and reduces bias. into the inventory system and how it is communicated to the shipper or clients. • Describe how the location for newly arrived shipments is tracked in the Workshop 3A • 07:00 – 09:30 repository after receipt and what immediate process/handling steps must take place, as needed. Part 1: Issues to Consider in Designing a Repository Part 2: The Nuts and Bolts of Operating a Repository Workshop 3C • 11:30 – 13:00 Facilitators: Katherine C. Sexton MBA, William E. Grizzle MD, PhD This workshop seeks to educate the audience on the various issues that need to Creating Successful Training Programs for be recognized and dealt with in designing and managing a biorepository. The Repository Staff workshop will be useful to anyone thinking about or planning to establish a Facilitators: Karen Pitt, PhD, Alexandra Lerch-Gaggl, PhD biorepository, as well as others who may have already started one, but would be interested in finding out how to further develop and expand their biorepository This course will teach participants the important components of successful services. Part 1 of this workshop leads the audience through questions that training programs for repository staff. Areas covered will include the should be asked and answered when considering the establishment of a human identification of training needs in repositories, development of effective training tissue biorepository. The answers to the questions will help them design the tools, an understanding of the skills needed for the trainer and trainee, and biorepository that is right for their needs. Part 2 delves more deeply into the a process for implementing the training that includes the creation of training details and issues of running and maintaining a biorepository. records. This information will be applicable to a broad range of specimen types (e.g., human, non-human, museum, etc.). Objectives: Objectives: • Gain insight about the various repository models available • Learn what issues should be considered when designing and operating a • Evaluate the role of training in effective repository operations and the repository preparation of high quality specimens for research. • Discuss the various types of services your repository might want to • Discuss factors that contribute to effective training programs. provide (without performing the investigator’s research for them!) • Describe the qualities of those best suited to administer training. • Understand the importance of quality control and safety in the repository

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

ISBER Education and Training Workshop Summaries (separate registration not required) Saturday May 24, 2014

Workshop 1A • 08:30 – 09:30 Workshop 2A • 09:45 – 10:45

HELL OR HIGH WATER: THE ALBERTA CANCER RESEARCH WEATHERING THE STORM: ASSESSING BUSINESS CONTINUITY BIOREPOSITORY DISASTER READINESS, RESPONSE AND MEASURES IN BIOREPOSITORY OPERATIONS RECOVERY Facilitators: Kristina Robson, Andrew Brooks, PhD Facilitators: Nigel Brockton, PhD, Charlene Karvonen Natural disasters like hurricanes and earthquakes and other events like equipment In June of 2013, Calgary, Alberta, experienced unprecedented flooding. The failure and chain-of-custody issues can threaten the existence of established Alberta Cancer Research Biorepository (ACRB) biostorage facility was located in biorepository operations. To mitigate these risks, organizations should establish a site that was threatened, and ultimately engulfed, by the rising waters. During strategic plans outlining procedures and protocols that alleviate the effects this workshop attendees will work through simulated disaster scenarios to help a disaster might have on sample inventories and research operations. As drug them anticipate and prepare for multiple emergency situations. Participants will discovery and development become increasingly reliant on properly preserved be provided with and develop a template for their own Disaster Readiness, samples, protecting these materials has become an even greater priority. Response and Recovery Plan by responding to a MOCK Disaster. This will help This workshop will review a real-world case study in which hundreds of develop their emergency response plan, organize an approach for disaster thousands of research samples were rescued from New York University medical recovery plan and propose the minimum criteria for business resumption. centers in days after Hurricane Sandy.

Objectives: Objectives: • Learn how to prepare a plan for various potential disasters/threats. • Best practicing for selecting business continuity partners to support the • Learn how to organize your business resources to assist an effective protection of sample inventories. response to a disaster • How best to establish cost-effective redundancies and action steps that • Learn how to implement systems and processes to keep your Emergency your company can employ with research partners. Response Plan up to date. • Learn best practices in the development of a business continuity and disaster recovery plan to protect research samples. Workshop 1B • 08:30 – 09:30 Workshop 2B • 09:45 – 10:45 INFORMED CONSENT FOR GENOMICS: POLICIES, PROBLEMS AND PRACTICAL APPROACHES ELSI CHALLENGES IN BIOBANKING & GENOMICS RESEARCH Facilitators: Marianna J. Bledsoe, Amelia Warner, Anita Nelsen Facilitators: Pedro Rondot Radío, Rosario Isasi, Anne Marie Tassé This workshop will explore current policy developments and requirements Biobanking activities are of major scientific importance since they allow for the regarding genomic sequencing and genomic data sharing and informed creation of very large datasets - as needed to study complex disease aetiology -, consent practices when human specimens are used for genomics research. optimize the use of already collected research material and avoid the limitations It will address these issues from both a US and international perspective and of research conducted among smaller numbers of participants. While the literature emphasize practical approaches to overcome challenges in this area. Practical on biobanking has traditionally focused on issues such as informed consent, approaches and real world examples of regulations and policies for genomics privacy, access and return of research results, emergence of biobanking activities studies based on experiences from multinational clinical trials and other in new research domains, such as stem cell research, has raised unexpected multinational studies will be presented and discussed. socio-ethical and legal issues (ELSI). Moreover, internationalization of research activities and development of international research consortia has clearly shown Objectives: the limitations of nationally based legal and ethical frameworks. This workshop aims to provide the audience with the “building blocks” of ELSI in biobanking • Provide an overview of current policies and issues related to informed and genomics medicine. It has two distinct but complementary goals. First, the consent for genomics research. workshop aims to provide an overview of the most pressing ethical and legal • Discuss current approaches and practices on a global level that can issues in biobanking, and illustrate answers provided by the traditional normative facilitate the collection and use of human specimens for genomic research. approach to biobanking. Second, it aims to demonstrate the emerging issues raised by biobanking activities in novel research settings. Biobanking for stem cell research and international research consortia will be used as case studies to illustrate these new issues, as well as the latest ethical and normative responses.

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

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Attend Tuesday, May 20th at 5:15 pm Join us for “Managing the Past for the Future,” an exciting ISBER workshop featuring Joël Doré, Ph.D,41 Our ISBER MICALIS Institute, MetaGenoPolis, and INRA, France. Dr. Doré will describe the leading edge scientific research in the Human Gut Microbiome and use of CryoXtract’s frozen aliquotting technology as an Workshop www.isber.org integral part of INRA’s sample preparation workflow. Cocktail reception to follow. Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

International Society for Biological and Environmental Repositories Connect globally to leading professionals in BIOREPOSITORIES. Join ISBER today!

Organizational Membership: includes 2, 4, or 6 Individual Delegates access to ISBER Best Practices for Biorepositories and Self-Assessment Tool (SAT) product/service posting on ISBER MarketPlace online subscription to Biopreservation and Biobanking – ISBER’s official journal discounted exhibit space and registration rates for the ISBER Annual Meeting & Exhibits advertising opportunities at a discounted rate online jobs board at: www.biobankingjobs.com

Individual Membership: access to ISBER Best Practices for Biorepositories and Self-Assessment Tool (SAT) reduced registration rates for the ISBER Annual Meeting & Exhibits online subscription to Biopreservation and Biobanking – ISBER’s official journal online subscription to the ISBER Newsletter – the quarterly member e-newsletter Connect to a global group of professionals in biospecimen banking through the ISBER Members-only Forums online jobs board at: www.biobankingjobs.com

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T: 1-604-484-5693 • F: 1-604-874-4378 • E:[email protected] www.isber.org

43 Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014 Posters

ABSTRACT TITLE Presenter* Country ID SERUM ALBUMIN CONCENTRATIONS IN HIV PATIENTS BEFORE AND AFTER HIGHLY ACTIVE ANTI- BRS 01 RETROVIRAL THERAPY: A RETROSPECTIVE AND MULTI-ETHNIC COHORT IN LONDON, UK, USING BANKED Z. Kozlakidis United Kingdom DATA AND SAMPLES MULTILAYERED MOLECULAR PROFILING SUPPORTED THE MONOCLONAL ORIGIN OF METASTATIC RENAL BRS 02 S. Wu China CELL CARCINOMA BRS 03 WHOLE GENOME DEEP SEQUENCING DECOMPOSES THE GENOME EVOLUTION OF RENAL CELL CARCINOMAS S. Wu China BRS 04 CHINESE VIRUS RESOURCE AND BIO-INFORMATION CENTER T. Li China BRS 05 METHOD VALIDATION FOR STOOL DNA EXTRACTION G. Hamot Luxembourg BRS 06 APPLICATION OF THE CMA TECHNOLOGY IN STEM CELLS RESEARCH P. De Blasio United States BUILDING AND APPLYING A CHRONIC DISEASE BIOBANK BASED ON THE INFORMATIONIZATION OF BRS 07 M. Yuan China COMMUNITY HEALTHCARE IN SHANGHAI UTILITY OF CLINICAL CHEMISTRY ITEMS AS THE QUALITY ASSESSMENT MARKERS FOR DELAYED BLOOD BRS 10 H. Shin Korea, Republic of SEPARATION IN BIOBANKING THE BIOSPECIMEN METHODOLOGICAL STUDY (BMS): EVIDENCE TO GUIDE BEST PRACTICES FOR BRS 12 A. Rao United States POSTMORTEM TISSUE PRESERVATION EVALUATION OF PROGRP AS A QUALITY CONTROL MARKER FOR PROPER STORAGE OF FROZEN PLASMA BRS 13 S. Shin Republic of Korea SAMPLES IN A BIOBANK BRS 14 PRE-ANALYTIC VARIATION IN ANTIBODIES TO INFECTION FROM PERIPHERAL BLOOD V. Hodgkinson Australia BRS 15 CANDIDATE CYTOKINE MARKERS FOR QUALITY CONTROL OF DELAYED BLOOD SEPARATION IN BIOBANKING J. Lee Republic of Korea BRS 16 OPTIMIZATION OF PRESERVATION OF PERIPHERAL BLOOD MONONUCLEAR CELLS IN BIOBANK M. Sun China BRS 17 BIOBANKING AS A BASIS FOR PERSONALIZED MEDICINE PROGRAM (PMP) AT SHEBA MEDICAL CENTER Y. Cohen Israel BRS 18 DNA EXTRACTION FROM CLOTTED BLOOD USING A SEMI-AUTOMATED METHOD S. Kollis United States BRS 19 PRECISION LABORATORY NETWORK RNA PROCESSING SUITABILITY STUDY F. Bahunde United States BRS 21 NEW CONTAINERS FOR FROZEN TISSUE CONSERVATION STANDARDIZE THE CRYOSTAT SECTIONING PROCESS R. Lawlor Italy DNA FROM BUFFY COAT STORED IN A NOVEL BIOSTABILIZER AT ROOM TEMPERATURE PERFORMS BRS 22 M. Donaldson Canada EQUIVALENTLY TO DNA FROM FROZEN BUFFY COAT IN ILLUMINA INFINIUM GENOTYPING BRS 23 SIMPLE ASSAYS FOR MONITORING CELL HEALTH S. Withers United States BRS 24 REDUCING COST, ENERGY, AND SPACE CONSUMPTION FOR BIOLOGIGICAL SAMPLE STORAGE R. Heaton United States AN EMERGING ROLE OF BIOREPOSITORIES IN PERSONALIZED MEDICINE: ISOLATION AND PROCESSING BRS 26 OF PRIMARY TUMOR CELLS FOR THE ESTABLISHMENT OF 3D TUMOR CULTURES FROM SOLID TUMOR K. Valyi-Nagy United States SPECIMENS POTENTIALS AND PITFALLS IN BIOBANKING FOR BIOSPECIMENS OF NEUROLOGICAL RARE BRS 28 R. Ravid The Netherlands DISEASES(NRD’S) BRS 29 MEMBRANE STABILIZING EFFECT OF LIPOSOMES ON RAT RED BLOOD CELLS J. Acker Canada BRS 30 THE IMPACT OF STORAGE CONDITIONS ON DNA-DERIVED FROM BUCCAL SWABS C. White United States BRS 31 HCV STATUS AND OTHER PRE-ANALYTICAL VARIABLES INFLUENCE DNA YIELD FROM WHOLE BLOOD J. Hoskins United States BRS 32 TRACKING SAMPLE TEMPERATURE OVER TIME TO DETERMINE SAMPLE STABILITY IN BIOREPOSITORIES L. Clark United States BIOBANKING FOR MATERNAL AND CHILDREN’S HEALTH: A UNIQUE RESOURCE FOR LONGITUDINAL BRS 34 J. Pang China COHORT STUDY OF PREGNANT OUTCOMES BRS 36 INTERACTION BETWEEN GENETIC POLYMORPHISMS AND RISK OF ORAL CANCER G. Wong Malaysia

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

ABSTRACT TITLE Presenter* Country ID A MODEL FOR ACCELERATING RARE RESEARCH THROUGH LINKING PATIENT CLINICAL DATA TO BRS 37 Y. R. Rubinstein United States BIOSPECIMENS REQUESTING AND SHARING REAGENTS, BIOSPECIMENS AND DATA THROUGH THE NEW TECHNOLOGY ELSI 02 M. Henderson United States AGREEMENT DASHBOARD AT THE US NATIONAL INSTITUTES OF HEALTH. IT’S EASY! ELSI 04 COVERING THE CONSENT FORM AND PROCESS: THE LIVER DISEASE BIOBANK EXPERIENCE A. Salman Canada ETHICAL ISSUES SURROUNDING INFORMED CONSENT AS ENCOUNTERED BY THE NHLS STELLENBOSCH ELSI 05 B. Van Rooyen South Africa BIOBANK – H3AFRICA THE SUSTAINABILITY OF BIOREPOSITORIES: THE ETHICAL DILEMMAS OF INFORMED CONSENT IN THE ELSI 09 K. D’Angelo United States FACE OF COMMERCIALIZATION ELSI 10 PARTICIPANT AUTONOMY AND UNDERSTANDING IN OPEN ACCESS DATA SHARING S. Pereira United States EPSR 04 The International Environmental Specimen Bank (IESB) Group R. Pugh United States EPSR 05 PLANT VIRUS GENBANK J. An Republic of Korea HSR 01 PATHOLOGISTS’ ASSISTANT ROLE IN A BIOBANK M. Rau United States HSR 02 A CALL TO STANDARDIZE PREANALYTIC DATA ELEMENTS FOR BIOSPECIMENS J. Robb United States STORAGE OF URINE ON MEMBRANE MAKES THE COMPREHENSIVE BIOBANKING OF CLINICAL SAMPLES HSR 04 Y. Gao China POSSIBLE HSR 05 KOREA GYNECOLOGIC CANCER BANK H. Kwon Republic of Korea HSR 06 STREAMLINE BIOSPECIMEN AVAILABILITY AND MAXIMIZE QUALITY TO ADVANCE PERSONALIZED MEDICINE A. Liu United States HSR 07 DEVELOPMENT OF A SEER VIRTUAL TISSUE REPOSITORY G. Rosenfeld United States THE CENTER FOR REGENERATIVE MEDICINE (CRM) BIOTRUST: A BIOBANK FACILITATING THE HSR 08 Z. Resch United States TRANSLATION OF REGENERATIVE THERAPIES AT MAYO CLINIC ESTABLISHMENT OF MINHANG BIOBANK BASED ON ELECTRONIC HEALTH RECORD SYSTEM IN HSR 09 Y. Zhao China SHANGHAI, CHINA A BIOBANK-BASED SOLUTION FOR A MULTI-INSTITUTIONAL WORKING GROUP FOR THE STUDY OF PENILE HSR 11 A. Campos Brazil CARCINOMA IN BRAZIL ESTABLISHMENT AND MAINTENANCE OF A STANDARDIZED GLIOMA TISSUE BANK: HUASHAN HSR 12 A. Aibaidula China EXPERIENCE ONE SMALL STEP FOR BIOBANKING: WORKING TOWARDS IMPROVED NETWORKING OF CANCER HSR 13 A. Rush Australia BIOBANKS HSR 14 THE NIDDK CENTRAL REPOSITORIES: AN NIH RESOURCE FOR RESEARCH ON TYPE 1 DIABETES R. Rasooly United States DESIGN AND IMPLEMENTATION OF A NATIONWIDE, IN-HOME, BLOOD COLLECTION IN THE WOMEN’S HSR 15 S. Mann United States HEALTH INITIATIVE AUSTRALIA’S NEXT TOP MODEL: EXPEDITING AND SIMPLIFYING INFORMED CONSENT FOR SAMPLE HSR 16 N. Sprigg Australia DONATION AT DIAGNOSIS OF ACUTE HEMATOLOGICAL MALIGNANCIES HSR 17 BUSINESS PLANNING FOR ASSESSING AND DEVELOPING A PEDIATRIC AND WOMEN’S ORIENTED BIOBANK T. Tarling Canada HSR 18 DEVELOPING TUMOR TISSUE BANK TO ACCELERATE CANCER TRANSLATIONAL RESEARCH H. Li China FACTORS INFLUENCING SPECIMEN ACCRUAL IN A BIOBANK WITH AN ATTEMPT TO UNDERSTAND THE HSR 19 S. Tolay United States GENERAL MINDSET OF THE POPULATION: A COMMUNITY HOSPITAL PERSPECTIVE HSR 20 THE VENTYX WESLEY RESEARCH INSTITUTE TISSUE BANK E. Raymond Australia

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

ABSTRACT TITLE Presenter* Country ID NATIONAL CHILDREN BIOBANK IN CHINA: THE FOUNDATION OF TRANSLATIONAL MEDICINE RESEARCH HSR 21 P. Chu China IN PEDIATRIC FIELDS HSR 22 A NOSOCOMIAL CLINICAL SPECIMEN BANK IN LARGE COMPREHENSIVE HOSPITAL L. Yin China HSR 23 BIOBANK BRANCH, CHINA MEDICINAL BIOTECH ASSOCIATION H. Zhou China HSR 25 BIOBANK OF NATIONAL ENGINEERING CENTER FOR BIOCHIP AT SHANGHAI H. Zhou China HSR 26 BIOBANKS SHIFT TO PRECISION MEDICINE P. De Blasio United States CREATION AND INITIAL IMPLEMENTATION OF A FEDERATED TISSUE REPOSITORY SYSTEM AT AN HSR 27 J. Galbraith United States ACEDEMIC MEDICAL CENTER WITH MULTIPLE PRE-EXISITING BIOREPOSITORIES HSR 28 THE GENOTYPE-TISSUE EXPRESSION PROJECT L. Carithers United States HSR 29 SPECIAL CONSIDERATIONS FOR BIOBANKING OF INFECTIOUS DISEASES IN CHINA L. Liu China THE NATIONAL CANCER INSTITIUTE SPECIMEN RESOURCE LOCATOR A SEARCHABLE DATABASE TO HSR 31 J. Demchok United States LOCATE HUMAN SPECIMENS HSR 32 THE UK BREAST CANCER CAMPAIGN TISSUE BANK (BCCTB) B. Matharoo-Ball United Kingdom HSR 33 LIVER DISEASE BIOBANK: A MOVING TARGET FOR RESEARCH AND CLINICAL STUDY INTEGRATION A. Lazaris Canada HSR 34 DATA ON THE DEVELOPMENT OF RESOURCES FROM A 2-YEAR-OLD TUMOR BIOBANK IN NEW ZEALAND D. Mason New Zealand BIOLOGICAL SPECIMEN RESOURCES AND ITS EPIDEMIOLOGICAL DATABASE FOR ADVERSE PREGNANCY HSR 36 C. Huang China OUTCOMES: FROM A COHORT STUDY HSR 37 CONSTRUCTION OF CHRONIC KIDNEY DISEASE BIOBANK IN BEIJING X. Zhang China NANJING BIO-BANK, A HEALTH DEPARTMENT DOMINATED AND HOSPITAL SUPPORTED MULTI-CENTER HSR 38 Q. Ye China BIO-BANK IN CHINA HSR 39 BUILDING A QUALITY DRIVEN GLOBAL LABORATORY NETWORK FOR PRE-ANALYTICAL PROCESSES K. Shea United States HSR 40 STREAMLINING TRANSLATIONAL RESEARCH THROUGH INTEGRATED BIOBANKING AND CORE FACILITIES B. Pruetz United States HSR 42 AN INFORMATIONAL CHILDREN’S BIOBANK S. Liu United States ROOM TEMPERATURE BIOSPECIMEN TRANSPORTATION THROUGHOUT AFRICA AS AN ALTERNATIVE COST HSR 43 C. Swanepoel South Africa EFFECTIVE SOLUTION TO COLD CHAIN LOGISTICS: THE NSB-H3A EXPERIENCE DEVELOPING RECOMMENDED BEST PRACTICES FOR BIOBANKING OPERATIONS AND GOVERNANCE FOR HSR 45 S. Dry United States THE UNIVERSITY OF CALIFORNIA SYSTEM HSR 46 EXPANSION OF A MULTIDISCIPLINARY BIOBANK TO A SISTER SATELLITE D. Larson United States BIOSPECIMEN PREPARATION AND BIOPROCESSING TECHNIQUES THAT OPTIMIZE SAMPLE COLLECTIONS HSR 47 K. Robson United States FOR FUTURE RESEARCH HSR 48 DIAGNOSTIC PATHOLOGY – KEY TO BIOBANKING SUSTAINABILITY Z. Prodanovic Australia HSR 49 ESTABLISHMENT OF FUDAN UNIVERSITY BIOBANK NETWORKING M. Sun China HSR 50 THE DUKE HUMAN HEART REPOSITORY (DHHR) D. Bowles United States ESTABLISHING A JOINT BREAST CANCER BIOBANK WITH A SHAREABLE SPECIMEN AND DATA HSR 51 A. Margossian United States COLLECTION AND TRACKING SYSTEM POSSIBLE LINK BETWEEN PLUTONIUM EXPOSURE AND RARE LIVER CANCERS REVEALED BY THE RUSSIAN HSR 52 C. Loffredo United States RADIOBIOLOGICAL HUMAN TISSUE REPOSITORY (RHTR) METABOLIC DISEASES BIOBANK AT SHANGHAI JIAO TONG UNIVERSITY AFFILIATED 6TH PEOPLE’S HSR 53 C. Wang China HOSPITAL, SHANGHAI, CHINA

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

ABSTRACT TITLE Presenter* Country ID BIOBANKING OF CIRCULATORY TUMOR CELLS (CTCs) AND THEIR RELATED MATERIALS AT CLINICAL HSR 54 K. Furuta Japan LABORATORIES THE APPLICATION OF “DISEASE-SPECIFIC INFORMATION CARD” IN THE MANAGEMENT OF MULTIPLE HSR 56 J. Zhou China DISEASES BIOBANK HSR 57 ESTABLISHING A HIGH QUALITY BIOBANK TO PROMOTE PEDIATRIC TRANSLATIONAL RESEARCH J. Zhou China BUILDING A STATE OF ART BIOREPOSITORY BY HYBRIDIZING ELECTRONIC DATA CAPTURE SYSTEMS IN A HSR 58 S. Ezzat Egypt LIMITED RESOURCE COUNTRY HSR 60 ESTABLISHMENT OF THE QUEBEC PANCREATIC CANCER STUDY (QPCS) A. Hall Canada THE NINDS REPOSITORY: A PUBLIC COLLECTION OF BIOMATERIALS FOR GENE AND BIOMARKERS HSR 61 C. Tarn United States DISCOVERY IN NEUROLOGICAL RESEARCH THE VAN ANDEL RESEARCH INSTITUTE’S PROGRAM FOR BIOSPECIMEN SCIENCE: BIOREPOSITORY HSR 62 S. Jewell United States MANAGEMENT FOR THE MULTIPLE MYELOMA RESEARCH FOUNDATION’S COMMPASS CLINICAL TRIAL HSR 64 CONDUCTING A BIOSPECIMEN COLLECTION BY MAIL: APPROACHES, SUCCESSES AND LESSONS LEARNED S. Sawyer United States HELL OR HIGH WATER: THE ALBERTA CANCER RESEARCH BIOREPOSITORY DISASTER READINESS, HT 01 C. Karvonen Canada RESPONSE AND RECOVERY MAXIMIZING RESEARCH IMPACT ACROSS BIOREPOSITORIES: TOOLS FOR CREATING ACCESSIBLE, OPEN HT 02 SOURCE METADATA RECORDS TO IDENTIFY BIOSPECIMEN AVAILABILITY, USE AND ANALYSIS ACROSS J. Mcnally United States REPOSITORIES HAVE BIOSPECIMENS WILL TRAVEL ...MAYBE! (LESSONS LEARNED IN POLICY DEVELOPMENT REGARDING HT 03 N. Sieffert United States BIOSPECIMEN TRANSFER FOLLOWING PI DEPARTURE) HT 04 CLINICAL BIOSPECIMENS CERTIFIED FOR NOMINAL PROPERTIES F. Betsou Luxembourg RAT 01 AN AUTOMATED LABORATORY WORKFLOW FOR BLOOD FRACTIONATION AND DNA EXTRACTION J. Gorman United States RAT 02 EFFECTIVE FECES ALIQUOTTING WORKFLOW SUPPORTS INCREASED MICROBIOME RESEARCH J. Dore France ELIMINATING FREEZE-THAW CYCLING OF FROZEN BLOOD SAMPLES USING FROZEN ALIQUOTTING RAT 03 M. Barnes United States TECHNOLOGY COMBINATION OF ELECTRONIC INFORMATION SYSTEM AND PRINTED RECORDING PROMOTE RAT 04 Z. Gao China MANAGEMENT EFFICIENCY IN NON-AUTOMATED BIOBANK TELEPATHOLOGY TO IMPROVE COLLABORATION AND QUALITY OF SAMPLES ANNOTATION IN RAT 05 R. Labib Egypt BIOREPOSITORY RAT 06 BIOBANK GRAZ: UNIQUE AUTOMATED PIPETTING WITH DIRECT FREEZING OF ALIQUOTS K. Sargsyan Austria RM 01 THE CREATION OF A STANDARD TERMINOLOGY FOR BIOBANKING H. Ellis United States RM 02 EFFECTIVE CLINICAL ANNOTATION OF TISSUE BANK PARTICIPANTS: THE CBCF TUMOR BANK EXPERIENCE A. Driga Canada RM 03 PURCHASING DATABASE SOFTWARE FOR IMPLEMENTATION INTO A BIOBANK E. Raymond Australia D. Simeon- RM 04 ANALYSIS OF INDUSTRY REQUESTS FOR BIOSPECIMENS Switzerland Dubach RM 05 BIOSTOR: A CUSTOMER-CENTERED INFORMATICS PORTAL FOR THE BOSTON CHILDREN’S HOSPITAL BIOBANK R. Chakrabarty United States THE FUTURE OF DATA PRESENTATION OR HOW MEDICAL UNIVERSITY OF SOUTH CAROLINA BUILT AN RM 06 INTEGRATED DATA MANAGEMENT SYSTEM THAT ALLOWS DIFFERENT DATA SOURCES TO RELATE TO COMMON W. Morgenweck United States ELEMENTS ACROSS THE ENTIRE MEDICAL UNIVERSITY ENVIRONMENT THAT IS EASY TO UNDERSTAND RM 07 INCREASING SPECIMEN VISIBILITY AND ACCESSIBILITY THROUGH BIOBANK INFORMATICS H. Dowst United States APPLYING END-TO-END REAL WORLD PROCESS INFRASTRUCTURE TO BIOBANKING IN THE RM 08 K. Wiles United States ACADEMIC SETTING

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

ABSTRACT TITLE Presenter* Country ID SUSTAINING AND MAXIMIZING THE SCIENTIFIC VALUE OF HISTORICAL COLLECTIONS: THE NHLBI RM 09 E. Wagner United States BIOREPOSITORY BUSINESS PLAN RM 10 BIOBANK IN SUDAN: CURRENT STATUS AND PROSPECTS I. Abdelhalim Sudan D. Simeon- RM 11 ARE BIOBANKS USING THE BIOSPECIMENS THEY ARE COLLECTING? Switzerland Dubach RM 12 THE ROLE OF BIOBANKS IN RESEARCH, INNOVATION & FORENSICS: SOUTH AFRICAN PERSPECTIVE B. Duma South Africa RM 13 CDR – NCI’S COMPREHENSIVE IT PLATFORM MANAGING BIOREPOSITORY OPERATIONS P. Guan United States RM 14 DESIGNING BIOBANK INFORMATIC PLATFORM FOR TRANSLATIONAL MEDICINE L. Liu China RM 15 A PRACTICAL TOOL FOR MODELING BIOSPECIMEN USER FEES L. Matzke Canada RM 16 BIOBANK CATALOGUE 2.0 AND BEYOND L. Mook The Netherlands RM 17 SUSTAINABILITY IN BIOBANKING – NOTTINGHAM HEALTH SCIENCE BIOBANK B. Thomson United Kingdom INTEGRATING SPECIMEN STORAGE, RESEARCH MANAGEMENT, AND CLINICAL RESULTS: DEVELOPING A RM 19 A. Mews Australia RESEARCH INFORMATICS SYSTEM FOR A HOSPITAL-INTEGRATED HUMAN TISSUE BIOREPOSITORY NWBIOTRUST: A CROSS-INSTITUTIONAL INFORMATICS INFRASTRUCTURE FOR REQUESTING AND RM 20 S. Ponko United States MANAGING ANNOTATED HUMAN BIOSPECIMENS RM 21 NEW GENERATION -80°C FREEZERS FOR BIOREPOSITORY STORAGE K. Kruckeberg United States EXPLORING THE POTENTIAL FOR INTEGRATION OF BIOBANKS INTO DIAGNOSTIC LABORATORIES IN NEW RM 22 D. Mason New Zealand ZEALAND TO IMPROVE BIOBANK SUSTAINABILITY RM 23 ARE WE READY FOR SUSTAINABLE BIOBANKING? A CALL TO ACTION E. Steinfelder The Netherlands TRANSFORMING BUSINESS OPERATIONS OF AN ACADEMIC BIOREPOSITORY THROUGH THE UTILIZATION RM 24 K. Wease United States OF MEASURABLE KEY PERFORMANCE INDICATORS RM 26 CENTRALIZING REQUEST AND SAMPLE INTAKE S. Hogen United States RM 27 THE NEED FOR BUSINESS CONTINUITY AND DISASTER RECOVERY PLANNING FOR RESEARCH SAMPLES L. Ball United States A CASE COMPARISON IN COSTS BETWEEN ESTABLISHING LOCAL, INDEPENDENT, RESEARCH RM 28 COLLECTIONS TO THE UTILIZATION OF AN ESTABLISHED BIOREPOSITORY TO FULFILL RESEARCH NEEDS IN A. Tran United States A LONGITUDINAL STUDY BUILDING A REDACTION SYSTEM (REDS) WITH SCIENTIFIC DICTIONARIES AND REGULAR EXPRESSION Z. RM 29 United States MATCHING ALGORITHMS (REMA): TO DELETE OR NOT DELETE Vonmenchhofen RM 30 DEVELOPING A COST-RECOVERY MODELING TOOL FOR LONG-TERM SUSTAINABILITY OF BIOBANKS H. Odeh United States RM 31 MAXIMIZE INTEROPERABILITY IN COLLABORATIVE BIOBANKS FOR SHANGHAI BIRTH COHORT W. Wang China RM 32 MANAGEMENT OF RESEARCH PROJECTS BY THE AUSTRALIAN BREAST CANCER TISSUE BANK J. Carpenter Australia BIOREPOSITORY MANAGEMENT AS THE COMPREHENSIVE BIOSPECIMEN RESOURCE (CBR) FOR THE RM 33 D. Rohrer United States NATIONAL CANCER INSTITUTE’S (NCI) CANCER HUMAN BIOBANK (caHUB) RM 34 BIOBANK NETWORK: ACCESSIBILITY OF RESOURCES ACROSS REGIONAL BIOBANKS Y. Wang China EFFECTS OF ONE-INCH CONCEPTS COMBINES WITH 10 X 10 CONFIGURATION IN CRYOGENIC STORAGE RM 35 X. Li China ON THE BIOSPECIMEN SAFETY AND BIOBANK ECONOMY MANAGEMENT OF PROSPECTIVE PROCUREMENT OF RESEARCH BIOSPECIMENS: APPLICATION OF A WEB- RM 36 R. Mandt United States BASED INFORMATION SYSTEM TISSUE MORPHOMETRICS USING DEFINIENS TISSUE STUDIO 3.5 FACILITATES TISSUE BASED DATA RM 38 R. Mandt United States COLLECTION AND MANAGEMENT

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

ABSTRACT TITLE Presenter* Country ID RM 39 ENSURING THE FUTURE SUSTAINABILITY OF A DISEASE SPECIFIC BIOBANK T. Yeadon Australia RM 40 PREDICTIVE ANALYTICS FOR BIOSPECIMEN AND BIOREPOSITORY MANAGEMENT OPTIMIZATION L. Monovich United States RM 41 WHICH BUSINESS MODEL FOR BIOBANKS? R. Warth Switzerland RS 01 HOW TO GUIDE FOR GENERATING BIOSPECIMEN IDENTIFIER S. Nussbeck Germany QUALITY ASSESSMENT OF PROSTATE TISSUES FROM BENIGN PROSTATIC HYPERPLASIA PATIENTS RS 02 A. Lin China OPERATED WITH TURP PROCEDURES AND RADICAL PROSTATECTOMY DEVELOPMENT OF AN AUTOMATED DNA CLEAN-UP PROCEDURE TO IMPROVE DNA SPECIMEN QUALITY RS 03 S. Hall United States FOR USE IN GENOMIC TECHNOLOGIES A COMPREHENSIVE MULTIDISCIPLINARY BIOREPOSITORY AND CORE MOLECULAR LABORATORY RS 04 T. Geddes United States QUALITY PROGRAM RS 06 QUALIFICATION OF DIGITAL PATHOLOGY SYSTEMS FOR A BIOSPECIMEN REPOSITORY T. Barr United States DEVELOPING A GOLD STANDARD FOR NUCLEIC ACID QUALITY CONTROL: THE IMPORTANCE OF SAMPLE RS 07 A. Brooks United States QUALITY AND IDENTITY IN A BIOREPOSITORY SETTING RS 08 BEST TOOLS FOR QUALITY SAMPLE MANAGEMENT TRACKING N. Verna United States RS 09 HUMAN PERIPHERAL BLOOD LEUCOCYTE COLLECTION AND QUALITY CONTROL H. Jin China RS 10 DNA FINGERPRINTING: SHERLOCK HOLMES IN THE BIOBANK. A CASE STUDY O. Kofanova Luxembourg AN EVIDENCE BASED FRAMEWORK FOR DEVELOPMENT OF “FIT FOR PURPOSE” BIOBANKING SAMPLE RS 11 L. Miranda United States MANAGEMENT PROTOCOLS THE INFLUENCE OF FROZEN THAWING ON RNA QUALITY OF CANCER-TISSUES WITH DIFFERENT RS 12 Y. Wang China PRESERVING METHODS RS 13 AUTOMATED PBMC EXTRACTION FROM WHOLE BLOOD W. Ammerlaan Luxembourg RS 14 COMPARATIVE EVALUATION OF RNA EXTRACTION FROM HEALTHY AND FAILING HUMAN MYOCARDIUM L. Martin United States DEVELOPMENT OF STATISTICAL PROCESS CONTROL PARAMETERS FOR TISSUE QUALITY IN A PREGNANCY RS 15 D. Chaffin United States RELATED BIOREPOSITORY A STREAMLINED PROCESS FOR RECOVERY AND QUALITY ANALYSIS OF DONOR-VERIFIED, HIGH-QUALITY RS 16 V. Kelly United States TOTAL RNA INCLUDING miRNAS FROM PAXGENE RNA BLOOD TUBES RS 17 RETROSPECTIVE ANALYSIS OF REPORTED ERRORS FOR DEVELOPMENT OF KEY PERFORMANCE INDICATORS K. Wiles United States RS 18 THE ROLE OF CLINICAL COMMISSIONER IN BIO-BANK CONSTRUCTION D. Cui China INNOVATIVE TEACHING AND LEARNING APPROACHES FOR CONTINUING PROFESSIONAL DEVELOPMENT RS 19 EDUCATION IN THE CLINICAL, BIOLOGICAL AND ENVIRONMENTAL BIOBANKING SECTORS A TRANS- F. Betsou Luxembourg DISCIPLINARY UNIVERSITY CERTIFICATE IN THE PRINCIPLES OF BIOBANKING MONITORING ADEQUACY OF SPECIMENS RECEIVED BY THE BIOPATHOLOGY CENTER (BPC) AT RS 20 L. Noyes United States NATIONWIDE CHILDREN’S HOSPITAL RS 21 THE IMPACT OF A COMPREHENSIVE QUALITY MANAGEMENT PROGRAM D. Valley United States RS 22 DEVELOPING A CONTINUING EDUCATION PROGRAM FOR A BIOREPOSITORY E. Pumplun United States RS 23 TARGETED COLLECTION PROTOCOL FROM INTACT PROSTATECTOMY SPECIMENS A. Sharp United States

* All abstracts are listed by the presenting author (listed at the time of submission)

www.isber.org Custom BioGenic Systems

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

data management experience to their users. Whether you are an independent Sponsors researcher or a member of a large research institution, SmartBiobank is designed to meet all your data management needs. Airgas (Booth 220) AutoGen Inc (Booth 105) Airgas provides the right solutions for repository and specimen management. From cryogenic storage systems and liquid nitrogen to vacuum-insulated piping AutoGen is now the sole supplier of consumables to the worldwide QIAGEN and redundant monitoring and alarm systems, Airgas is the one source for Autopure LS installed base. advice and support for protecting irreplaceable biological and clinical samples. We provide state-of-the-art onsite or Airgas-managed offsite cryorepository Our newly released system, the AutoGen FLEX STAR, automates the isolation of facilities specifically tailored to your current and future storage requirements. pure genomic DNA from large volumes of whole blood, up to 30 per run, 90 For peace of mind maintaining regulatory compliance, reducing specimen risk, per day. It features positive sample tracking with internal bar code scanning, simplifying the management of your systems, and being proactive when it and the option for integration with the Perkin Elmer Janus liquid handler to comes to preventive maintenance, you’ll find it with Airgas. automate sample input and DNA transfer steps. It uses Qiagen’s FlexiGene reagents to produce high quality, high molecular weight DNA ready for long Visit us at exhibit number 220. term storage, Next-Gen Sequencing, MDx Assays and more. Visit us at booth 105. AutoGen, Inc., 84 October Hill Road, Holliston, MA 01746, Tel: 774-233- Artificial Intelligence in Medicine Inc. (Booth 404) 3003, E-mail: [email protected], Web: www.autogen.com

FROM DISCOVERY TO DIAGNOSIS: AIM’s TissueMetrix information management Autoscribe Limited (Booth 120a) system is designed for research-orientated biospecimen repositories. It allows organizations to build and maintain a richly annotated catalog of biomaterials Autoscribe’s solution is a configurable sample tracking system that is applicable for current and future research. This information system is highly scalable, too. to bio-banking and bio-repository management. Our software enables you to Whether it’s a single collection with a small group of users or a multi-collection/ manage an ever increasing number of bio-samples (blood, tissue, DNA etc.) multi-institution environment with a large number of users, TissueMetrix will and to comply with rigorous regulatory requirements, such as HTA, GCLP, MHRA achieve your biobanking needs. All of this for as little as $90 per month per and national regulations. Samples need to be tracked at all times and it is user! Find out more at www.aim.ca, Email us at [email protected] or call us at essential to be able to record the complete genealogy for all samples and track 1.866.645.2224 to arrange a software demo Artificial Intelligence In Medicine the aliquots, pooled samples and derivatives of each sample. Autoscribe Matrix Inc., 2 Berkeley Street, Suite 403, Toronto, ON M5A 2W3, Canada Gemini is capable of all these things and more.

ASKION GmbH (Booth 101) Bahnson Environmental Specialties, LLC (Booth 303)

ASKION GmbH is your partner for modular bio bank system solutions up to Bahnson Environmental Specialties (BES), an EMCOR Company, located in completely automated sample handling and storage of biological material at Raleigh, NC is a leading Controlled Environmental Chamber Manufacturer highest quality standards in different sample formats at temperatures < -150 °C. that provides design, installation, service, & validation of standard or custom- The ASKION C-line system offers a bio bank solution, which gives you a maximum built Walk-In Controlled Environmental Chambers for close tolerance temp/RH of flexibility regarding sample formats as well as storage configuration. mainly to the pharmaceutical/biotech & research markets. Applications include: High capacity -75°C Cascade low temperature storage and Biorepository The ASKION C-line system features ice free storage, an uninterruptable cooling chambers, Walk-in Stability, HEPA Filtered Cold & Warm Rooms, Laboratory/ chain for your samples and a complete tracking of all data of the samples, down Bulk storage, Vaccine chambers, & in addition to standard incubators, warm to each single sample. Open interfaces enable the easy connection to labor / rooms, cold rooms & freezers. BES also has a complete line of ES2000 Reach-In hospital information systems as well as other external devices to the system. Environmental and Photostability Chambers. www.ESchambers.com

AstridBio Technologies Inc. (Booth 314) BASF/Metanomics Health (Booth 112)

SmartBiobank is a free, online data management application designed to Metanomics Health GmbH – a BASF Group company – applies comprehensive meet research needs by incorporating new technologies like cloud-based data Metabolite Profiling (metabolomics) with biomedical data interpretation. storage and secured data access. The aim of this system is to be able to integrate Metabolite Profiling is defined as the parallel analysis of multiple endogenous different types of research data into one single system that is easily accessible. metabolites in biological systems. The core expertise of Metanomics Health The SmartBiobank team was developed by a combination of experienced IT resides in discovery and validation of biomarkers. developers and scientific personnel who aim at providing a highly satisfying

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

MxP™ Quality Control Plasma is the first validated assay for holistic human Cryoboxes mean always 10 x 10 to store 23% more samples compared with 9 x plasma quality control. Its results provide information about the presence of 9 boxes, our CryoKING line brings One Inch Revolution which can double your pre-analytical deviations and where they occur in the process. MxP™ Quality sample storage with half the space and cost. Control Plasma identifies samples with insufficient quality and thereby helps maximizing success for clinical biomarker research. Biomatrica BioCision (Booth 113) Corporate Workshop, Tuesday May 21, 16:00 - 17:00 Biomatrica provides ambient temperature preservation technologies for DNA, BioCision is the innovation leader in products that improve standardization and RNA, proteins, cells and entire assays. Our customers include biobanks, eliminate temperature variability in sample handling, storage and transport. laboratories and manufacturers seeking to stabilize patient samples and purified BioCision products feature advanced thermal management technology and analytes. Biomatrica saves customer’s money by eliminating expensive cold smart ergonomic design to address and support the workflow needs of bench chain storage and shipment of sensitive biological molecules, while protecting top processes, bioprocessing and other cold chain logistics. The CoolCell® family sample and assay integrity. of products standardizes cell cryopreservation and are widely used in cell therapy applications. The CoolBox™, CoolRack® and CoolSink® portfolios eliminate variability in sample cooling, (snap)freezing, thawing and short transport. BioMicroLab (Booth 114) BioCision is committed to setting new standards in precision, consistency, BioMicroLab is an innovator of benchtop sample automation instruments reliability and reproducibility. which provide drug discovery productivity tools for life science researchers. Our instrument offering helps improve laboratory efficiency by automating BioFortis (Booth 213) tasks associated with sample handling and by integrating multiple laboratory applications onto a single automation platform. At BioFortis we focus on cutting-edge software to empower researchers in biobanking, biomarker discovery, clinical and translational research to make BioMicroLab offers researchers three types of sample management productivity data useful by making data smarter. Our award-winning Labmatrix software systems, these include: (1) volume inspection systems, (2) tube and vial based offers a holistic, secure and compliant platform for next generation sample and sorting, weighing, and liquid handling systems, and (3) 2D barcode decoding sample data management to meet the demands of biomarker-based trials and systems. All of BioMicroLab’s robotic platforms are compatible with SBS standards translational studies that are the foundation of personalized medicine. Today, to ensure integration with other automation oriented robotics and labware. Labmatrix is powering these next generation biobanks at pharmaceutical, biotechnology, government, research hospital and academic organizations. Biosero, LLC (Booth 203)

Biolife Solutions (Booth 215a) In addition to developing our own products, we bring together a consortium of companies which provide scientists with products and services for complete BioLife Solutions develops, manufactures and markets biopreservation media laboratory automation solutions. Products include liquid handling, capping and high performance thermal packaging products for cells, tissues, and and decapping, microplate sealing, hoods and enclosures, integration and organs. The Company’s proprietary HypoThermosol® and CryoStor® platform of scheduling software, robotic automation, and barcode scanning. All are solutions are highly valued in the biobanking, drug discovery, and regenerative uniquely designed with the highest level of engineering and performance in medicine markets. BioLife’s products are serum-free and protein-free, fully mind. Our company and our partners have developed proven products based on defined, and are formulated to reduce preservation-induced cell damage and communication with our customers in the Life Sciences industry including such death. BioLife’s enabling technology provides academic and clinical researchers areas as drug discovery, high throughput screening, proteomics and genomics. significant improvement in shelf life and post-preservation viability and function of cells, tissues, and organs. For more information please visit www. BioStorage Technologies (Booth 216) biolifesolutions.com. BioStorage Technologies, Inc. is the leading global provider of comprehensive Biologix Group Limited (Booth 108) sample management solutions for the bioscience industry. The company’s unique value is delivered by an expert team of global sample consultants, industry leading CryoKING- the leader and complete solution provider in the Biorepository temperature-controlled storage facilities, and state-of-the-art virtual sample Kingdom. As an ISO, FDA and CE certified manufacturer, Biologix will fit all of management and bioprocessing solutions. BioStorage manages the complete your BioBanking needs. Our CryoKING® Cryogenic Line includes Cryogenic Vials, lifecycle of outsourced, onsite or hybrid sample management solutions. With an Cryogenic Combo, Cryogenic Boxes, Freezer Racks, Scanner & Software. Biologix emphasis on quality, compliance and technology, we help companies maximize CryoKING 2D barcoded cryovials mean the ultimate identification, our CryoKING their research opportunities, minimize risk and reduce costs.

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

Brady Corporation (Booth 304) and sample management, use a robust cloud technology platform to give you access anytime, anywhere at virtually zero capex. The cloud based products Brady Corporation is an international manufacturer and marketer of high- are offered as Software-as-a-Service (SaaS). Our pay-as-you-go model enables performance labels, printing systems, software and safety products for a variety even small and medium laboratories to automate workflows and increase of industries around the globe. Brady has been developing durable labeling productivity. We offer a complete solution, meeting GLP, HIPAA &FDA guidelines, solutions for the lab market for over 12 years, focusing on specimen identification, including 21 CFR part 11 requirements for biobanks, molecular diagnostic labs tracking & storage applications as well as general labeling and safety applications and pharmaceutical companies.Please visit www.cloudlims.com for a free trial. within the Life Sciences and Industrial laboratory setting. Brady is headquartered in Milwaukee and employs 6,900 people at operations in the Americas, Europe Coldstash (Booth 402) and Asia/Pacific. Brady’s fiscal 2013 sales were approximately $1.15 billion. More information about Brady Corporation is available at www.bradycorp.com. Custody of your cryogenically stored specimen is your primary concern. Being more efficient in doing that is our concern. Coldstash’s driving force isto Brooks Life Science Systems (Booth 211, 310) create innovative new cryogenic storage, retrieval and delivery solutions that maximize freezer or dewar capacities for greater efficiencies as well as improved Brooks provides unparalleled experience in the provision of automated bio- workplace performance. Each component in our extensive cryogenic storage storage and sample processing solutions for biorepositories. Suppliers of product offerings gives you a unique advantage by having the ability to store the first automated DNA and also -80°C stores, Brooks understands the as much as 35% more samples in the same space. This allows you to maximize importance of sample integrity and provides a comprehensive range of bio- valued freezer space for additional cryogenic storage, reduce liquid nitrogen storage solutions from ambient to -80°C. With the largest installed base and consumption, and lower your energy costs. support network for automated sample management, Brooks has supplied over 200 stores worldwide. Complementary QC products for volume & precipitate College of American Pathologists (Booth 110) detection, tube & vial handling, REMP, Matri & Aurora consumables are also available. From standardized benchtop systems, to the world’s largest custom As the leading organization for board-certified pathologists, the College of installations, Brooks is the name scientists rely on. American Pathologists (CAP) serves patients, pathologists, and the public by fostering and advocating excellence in the practice of pathology and laboratory caTissue Plus (Booth 419) medicine worldwide. With more than 18,000 physician members, the CAP has led laboratory accreditation for more than 50 years with more than 7,500 CAP- caTissue Plus is a Free & Open Source Biospecimen Management Software. The accredited laboratories in 50 countries. core of caTissue is that “biospecimens without high quality data is of no value”. caTissue is used across the globe in some of the most respected biobanks of Computype (Booth 409a) various sizes and diseases. caTissue streamlines management of biospecimens across collection, consent, QC, request and distribution. Finally, caTissue Plus is For over 40 years, Computype has been the primary barcode and tracking highly configurable and customizable. E.g., adding a custom field or form can be solutions resource dedicated to reliable sample & container identification. done in minutes by a non-IT person. Krishagni actively develops newer versions With our full suite of laboratory offerings such as: Pre-labeled lab ware, tare of caTissue as well provides professional support. Support includes phone/email, weighing services, automation of all stages, and barcode labels that survive data migration, customizations, integrations, training, and so forth. almost any chemical testing or environment, Computype is your trusty toolkit for improving lab efficiency. Address: Computype, 2285 West County Rd C, St. chemagen from PerkinElmer, Inc. (Booth 317, 416) Paul, MN 55113, 800-328-0852, Email: [email protected], Website: www. computype.com/lifesciences, Twitter: @Computype chemagen a leading supplier of automation and reagents for fast and reliable magnetic bead based DNA and RNA extraction for sample volumes from 10 ul Coriell Institute for Medical Research (Booth 411) to 10 ml for blood, tissues, saliva, bacteria, food, PCR products. All functions can be performed on the one instrument. Advantages of this unique system are The Coriell Institute for Medical Research is an independent, non-profit biomedical fast processing, unmatched sample volume range and robust chemistry. Visit us research center based in Camden, New Jersey. Founded in 1953, the Institute is at booth # 317/416 for more information about the new chemagic 360 dedicated to unlocking the genetic code of human disease. The Coriell Biobank is regarded as the most diverse collection of highly-characterized cell lines and high- CloudLIMS (Booth 302) quality DNA, annotated with rich phenotypic data and available to the international research community. Additionally, Coriell is a pioneer in personalized medicine and CloudLIMS.com is a cloud based laboratory informatics company with a strong is exploring the promise of induced pluripotent stem cells – stem cells created from focus on data security and compliance. Our flagship products for biobanking skin or blood – and their role in disease research and drug discovery.

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Cryoxtract Instruments Booth (107, 206) to monitor equipment such as LN2 tanks and ULT freezers. In addition to temperature, we monitor humidity, O2, CO2, or essentially any parameter. Our CryoXtract delivers a unique set of instrument solutions to the scientific Web Access solution allows you to see the status of your system from anywhere community to protect biosample integrity, increase the utilization of critical without additional software, including your smart phone, tablet, or home PC. collections, and optimize scientific outcomes. For shipment monitoring, the LIBERO PDF in-transit datalogger requires no CryoXtract’s proprietary technology allows for the coring of multiple frozen software or hardware at the destination, and can be easily integrated to your aliquots from a single sample without exposing the parent to multiple freeze/ existing dry shippers. thaw cycles. CryoXtract will exhibit both the CXT750 automated sample aliquotter and the CXT350 benchtop sample aliquotter systems. Both instruments enable Fisher BioServices (Booth 405, 407) targeted and repeated access to a broad range of tissue and biofluid samples Fisher BioServices, part of Thermo Fisher Scientific, is a professional stem while maintaining their frozen -80oC state. The company will display successful cell and cell therapy services provider. With locations around the world, applications in genomics, proteomics, and human gut microbiome. Fisher BioServices is committed to providing biorepository storage, logistics infrastructure and clinical trial services to the cell therapy industry. Our facilities Custom Biogenic Systems (Booth 111) and capabilities enable us to provide integrated solutions from collection site or Custom Biogenic Systems will display a complete range of equipment and CMO to repository or clinical site. Services include biobanking and biorepository, accessories for cryogenic freezing and long term cryogenic storage. The -190C laboratory processing, cold chain logistics, kit production, qualification and ISOTHERMAL DRY STORAGE FREEZER, STANDARD OR CAROUSEL MODEL, validation, and biologic-API management. controlled rate freezing systems, and Ln2 dry shipping containers. Also displayed will be the NEW VERSALERT ALARM / MONITOR SYSTEM, plus freezer inventory Fluidigm Corporation (Booth 115a, 214a) systems for storing any type of sample. Avoid the embarrassment that comes from having misidentified samples in your biorepository. Fluidigm provides a rapid, simple, and high-throughput Denator AB (Booth 116) SNP genotyping panel that biobanks and biorepositories can use to identify Denator produces instruments and consumables, based on the company’s DNA samples and ensure traceability throughout the banking and downstream proprietary sample preservation technology, within the life science and clinical analytical processes. SNPtrace™Panel is an expertly designed panel using research markets. Fluidigm’s SNPtype™ Assays. The BioMark HD™ System and the 96.96 Genotyping IFC, combined with the SNPtrace™ Panel, delivers a cost-effective, The Stabilizor™ T1 enables scientists to ensure the quality and in vivo profile of easy to deploy, and easy to use workflow to determine or verify uniqueness, biological samples, by immediate and complete inactivation of enzymatic activity gender, and quality of a DNA sample prior to storage or for use in downstream otherwise causing sample change and degradation. Its additive free, and enables genomic analysis. For more information, visit www.fluidigm.com reliable analysis and quantification of proteins, peptides and their modifications. It can be used for all tissue types, fresh or frozen, allowing secure analysis also of Fluidx Ltd (Booth 410) stored samples. Stabilized samples have improved signal-to-noise ratio, enabling detection of low abundant molecules such as potential biomarkers. FluidX Ltd. provides innovative solutions for sample storage, tracking and management. Our continuing growth is a result of an ongoing commitment DNA Genotek (Booth 315a) to creative product development, while exceeding customers’ expectations and requirements for the high quality consumables, instrumentation and automation DNA Genotek provides high-quality biological sample collection, stabilization tools needed to help our customers’ succeed in their research. and preparation products for human genetics, microbiology and animal genetics. The company’s products protect and stabilize multiple sample types Freezerworks (Booth 202) for long-term storage at ambient temperature to ensure the highest quality results for genetic analysis and testing. The products’ reliability and ease-of- Providing configurable sample data management and biobanking software use have resulted in rapid adoption by thousands of academic, biotechnology, solutions since 1985. Track samples testing, reporting, billing and shipping diagnostic, agriculture, and other leading institutions around the globe. across multiple freezers and sites while managing biobank workflow. Safeguard data with comprehensive security features, 21 CFR part 11 compliance, ELPRO Services (Booth 200) and cryogenic-safe bar code and RFID labeling. Web service features assist integration with existing laboratory software and instruments as well as offer ELPRO manufactures dataloggers for biobank facility and in-transit monitoring. a secure option for specimen availability over the web. The Freezerworks Incorporate ELPRO’s fully scalable, redundant wired or wireless system configurable LIMS model puts the laboratory in charge, offering adaptability at

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

a fraction of the cost. Freezerworks is written and tested according to the FDA leading support and service. We strive to meet this challenge by placing a high General Principles of Software Validation. value on collaborative interactions, rapid delivery of solutions, and meeting the needs of our customers. Gas Cryo Systems (Booth 118) BSI Systems /Information Management Services Store your frozen samples extra safe below -90°c, and give yourself peace of (Booth 307) mind with our daihan freezers. We offer a “state-of-the-art“ ult freezer line with 2 totally separated freezing systems and redundancy at -80°c. Our warehouse is BSI is a powerful web-based system for biobank specimen management. BSI located in Clearwater, Florida. provides support for tracking all aspects of the specimen life cycle including subjects, consent, specimen acquisition, specimen storage, specimen request Greiner Bio-One (Booth 205) processing, and test results data collection in a secure, validated system. Configurable, customizable, and cloud-hosted, BSI provides a feature-rich A world-renowned partner for OEM, drug discovery, and diagnostics, Greiner environment that meet the needs of both large and small biobanks. Bio-One integrates injection-molding expertise with scientific innovation. Precision engineering, premium materials and advanced surface technologies IMV Technologies/Cryo Bio Systems (Booth 403) are employed to manufacture an extensive platform range for state-of-the-art methodologies in High-Throughput & High-Content Screening, Cell Culture, Cryo Bio System is the manufacturer of the .3ml and.5ml CBS High Security Immunology, Biochips & Biobanking. Visit gbo.com. Straws and automation. Our range of high security products and automation options can be utilized in a wide range of biorepository, epidemiological and Hamilton Storage Technologies (Booth 212) human ART applications. An international presence through subsidiaries in Italy, in the Netherlands, in the Hamilton Storage Technologies provides ultra-low temperature automated United States, in China and in India, and distributors in over 60 countries, offer sample management solutions for the life science industries. Products include customers both high quality products and expert technical support. Founded in -80°C biobanking and -20°C high-throughput tube and plate management 1987, Cryo Bio System is a division of IMV Technologies. systems. Our systems integrate with Hamilton Robotics’ automated liquid handling workstations for complete biobanking solutions. Our new LabElite™ www.Cryobiosystem-imv.com line of benchtop devices includes an automated decapper, automated 2-D barcode reader and a combination of the two devices to provide flexible ISENET-USA LLC (Booth 412) solutions for sample processing, tracking and security. Visit us in Booth 212 to learn more! www.hamilton-storage.com ISENET-USA LLC (www.isenet-usa.com) is one of the World Leaders in Tissue Microarray Technology. Its Galileo CKxxx Tissue Arrayers are covered by the NIH HighRes Biosolutions (Booth 222) Licence (US 6,699,710 & EP 2,318,984) and distributed exclusively in the USA by Transgenomic Inc. (www.transgenomics.com). We love automation. We design and build innovative robotic systems and The Galileo TMA are engineered by ISENET Italy (www.isenet.it) and assembled laboratory devices used by pharmaceutical and biotech companies and academic (and soon manufactured) by ISENET-USA LLC in the USA. research laboratories. HighRes helps scientists accelerate such areas as drug discovery, high-throughput genotyping, siRNA screening, next-generation The Galileo Tissue Microarrayers are available in 4 different models: Semi- sequencing sample prep, biorepository science, molecular diagnostics, and Automatic (CK2500 - designed to substitute the manual arrayers); CK3500 and more. We offer highly flexible, expandable and modular integrated systems and CK4500 (Computer assisted) which can interface with any commercial Digital bench-top devices that are easily configured (and reconfigured) for fast-paced, Scanner (Aperio, Hammatsu, TissueGnostics, etc.). dynamic laboratories. Kairos GmbH (Booth 414) Illumina ‘Kairos’ is headquartered in Bochum, Germany. Its strategic product is the Illumina is a leading developer, manufacturer, and marketer of life science tools biobanking and trial management system ‘CentraXX’, which allows for the and integrated systems for large-scale analysis of genetic variation and function. contextualization of sample data within the donor’s clinical history data. These systems are enabling studies that were not even imaginable just a few These data are collected and compounded from multiple primary IT-sources years ago, and moving us closer to the realization of personalized medicine. via interfaces, and made searchable and analyzable, thus significantly raising With rapid advances in technology taking place, it is mission-critical to offer the value of a biobank’s stock. Using a fully integrated workflow engine, solutions that are not only innovative, but flexible and scalable, with industry- ‘CentraXX’ orchestrates all relevant biobanking work processes in runtime and tailored to the individual actors. A trial management module with automatisms

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

for the recruitment of suitable test persons, as well as trial registry and trial clinic-based control collection (N>35,000 patients), includes deep phenotypic documentation functions, is also part of ‘CentraXX’. information from the electronic medical record that can be leveraged to meet the needs of a large number of study types and designs. KAYE (Booth 305) Mesa Labs (Booth 116a) Kaye trusted products & services help meet all your thermal validation and monitoring needs. Visit the Kaye booth # 305 to find out more about wired and The ViewPoint centralized monitoring system (CMS) from Mesa Monitoring is the wireless thermal validation systems; wireless process validation and, centralized most reliable way to protect valuable product, archive valuable data and receive facility monitoring, alarming and reporting systems. real-time alerts based on your acceptance criteria. ViewPoint is a networked system that monitors humidity, temperature/humidity, differential pressure, O2, Kaye LabWatch LT is a reliable, cost effective self-configurable solution to CO2, water detection, air velocity and much more. automate your continuous monitoring needs. Easy to install and simple to configure, this intuitive system provides continuous real-time monitoring of your Saving time and money, eliminating errors, and protecting your facility from critical environment conditions wirelessly and reliably .LabWatch LT is utilizing costly product loss, ViewPoint helps to keep your facility compliant with FDA, RF ValProbe wireless sensor technology with SmartMesh network and data AABB, CAP, DHS, and other regulatory agencies. Contact Mesa Monitoring redundancy for superior RF performance. today to learn more about our ViewPoint real-time monitoring solution.

LabVantage Solutions, Inc. (Booth 102) Micronic (Booth 104)

LABVANTAGE Solutions, Inc. is headquartered in Somerset, NJ with offices around Micronic is a global manufacturing company headquartered in Lelystad, the world. We offer a comprehensive portfolio of products and services for the Netherlands, and with US Sales and Production facility located outside of laboratory, including LIMS (Laboratory Information Management System), quality Philadelphia. Micronic products are manufactured and assembled in Class 7 electronic laboratory notebook (ELN), and business intelligence. Our industry- clean rooms where all products are certified as RNase, DNase and Endotoxin leading solutions and world-class services are the result of 30+ years of experience (pyrogen) free. Micronic produces an innovative line of products for traceable in laboratory informatics. We leverage that know-how with state of the art sample storage solutions. Micronic’s product line features 2D coded tubes in technology to help organizations redefine and optimize the way their laboratories volumes from 0.5ml to 7.5ml, automation friendly racks, capping options to fit conduct business. We have a proven track record of delivering return on investment all applications; including TPE capclusters, screw caps, low profile screw caps, to laboratories of all sizes and time zones. Our capabilities extend to legacy system code scanners, sample management software and equipment for capping and migration, global laboratory harmonization, and laboratory business intelligence decapping tubes/racks. derived from disparate sites and systems. LABVANTAGE delivers the best technical and domain expertise available to help you drive the success of your business. To MVE Chart (Booth 201, 300) find out more, visit http://www.labvantage.com. MVE Chart introduces the HEco™ and MVE Vario™ Series into our line of liquid Liconic (Booth 313) and vapor stainless steel freezers. We offer a complete range of stainless steel freezers with vial capacities ranging from 3.200 to 94.000. Our vapor units Liconic specializes in the design and manufacture of automated plate- and maintain -190˚C at the top storage box and still achieve the longest holding tube stores for storage solutions in laboratories and applications with special time and lowest LN2 consumption of any comparable freezer on the market. climate requirements. Our 20 years of leadership in this field has led to an MVE Chart also features a complete line of aluminum storage units including installation base of several thousands of systems in operation worldwide. By vapor shippers and nitrogen handling equipment. closely working with customers Liconic continually expands its product portfolio ensuring leading edge technology for today and tomorrow NHLBI – BioLINCC. Sharing Biospecimens and Data (Booth 413) Mayo Clinic Bioservices (Booth 315) The National Heart, Lung, and Blood Institute has supported data and Mayo Clinic Biorepositories provides customers with end-to-end services biospecimen collection for more than 130 studies. BioLINCC serves to related to collection, accessioning, sample processing, storage, management coordinate searches across these collections, and the BioLINCC website provides and distribution. The Biospecimens Accessioning and Processing (BAP) and a mechanism to request data and biospecimens for use by qualified researchers. Pathology Research Cores (PRC), located in a new state-of-the-art 35,000 The website can also be used to submit biospecimen collections to the NHLBI. square foot facility offers a variety of processing services including DNA/RNA extraction, automated fractionation and aliquoting, pathology services, kit building, robotic and standard storage capabilities. The Mayo Clinic Biobank, a

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

Pacific Bio-Material Management, Inc. • Cell Isolations from Peripheral Blood, Cord Blood or Bone Marrow Novare Bio-Logistics (Booth 204) • Generation of master and working cell stocks • DNA/RNA extractions Divisions of Pacific Bio-Material Management Inc., Pacific BioStorage and Pacific • Highly annotated specimen procurement Scientific Transport are leading providers of cGMP compliant storage, transport • Sample characterization and integrity assessment using a variety of of and cold chain management of biological materials at any temperature. immunological techniques At Pacific BioStorage, we provide storage solutions and manage valuable Promega (Booth 215) biological collections in a secure, cGMP compliant biorepository and provide worldwide logistical support, ensuring the integrity of our client’s material, Promega Corporation is a world leader in applying molecular biology and allowing them to focus on their core competency. biochemistry to the development of innovative, high value products for the life sciences. Stop by our booth to learn about our solutions for Biobanking Our transportation division, Pacific Scientific Transport (PST), is a leading cold including automated nucleic acid purification from blood and other sample chain logistic service provider, licensed and trained in the legal packaging and types, nucleic acid quantitation, and sample pre-qualification. transport of regulated chemicals, biological material and hazardous substances. www.pbmmi.com Rees Scientific (Booth 121)

Panasonic (Booth 314a, 316) For 30 years, Rees Scientific has been the industry standard for automated temperature monitoring. We specialize in monitoring your critical equipment and Known throughout the world as a leader in consumer electronics and appliances, protecting your valuable assets. Our Presidio Centron Monitoring System is a Panasonic addresses global needs such as energy, food, housing, health and complete solution to all of your environmental monitoring needs. We monitor information technology. Here at Panasonic Healthcare, we combine ideas and critical equipment in repositories and help meet standards for GxP, GMP, FDA, innovations from our worldwide network of industrial and consumer products AABB, Joint Commission, 21CFR11, and much more. Rees Scientific will continue into a complete line of biomedical laboratory products. For over forty years, we to build products and services that help provide resolutions for our customers. Our have established a reputation as a premier manufacturer of precision biomedical goal is to be a quality provider of systems, services and solutions for our clients. and laboratory equipment. Through this effort, we offer the industry’s most sophisticated refrigeration compressor design and state-of-the-art electronics to ultra-low and cryogenic freezers, refrigerators, incubators and environmental RUCDR Infinite Biologics (Booth 117) chambers. RUCDR Infinite Biologics is the world’s largest university-based biorepository specializing in custom genomic solutions. RUCDR provides comprehensive Praxair (Booth 406) services in bioprocessing, genomics, sample analytics and biostorage to government agencies, academic institutions, foundations, and biotechnology The largest industrial, medical, and specialty gases supplier in North America, and pharmaceutical companies within the global scientific community. By Praxair offers a broad portfolio of gas products with the purity, compliance, utilizing a state-of-the-art infrastructure and the highest quality biomaterials, and certification needed for your cryopreservation, laboratory or research RUCDR scientists convert precious biosamples into renewable resources thereby application. We work with users to implement the appropriate supply mode extending research capabilities. RUCDR maximizes the discovery process and from a complete range of cylinder, dewar, microbulk, and bulk options and protects precious biomaterial resources for future analyses allowing stakeholders help them protect the integrity of their high quality gases with Praxair’s full to optimize the value of biological assets. Innovative workflows, cutting edge line of ProStar™ Platinum regulators, manifolds and delivery systems. Praxair’s analytical approaches, and robust biomaterial storage processes enhance every products and services are making our planet more productive. collection.

Precision Bioservices (Booth 120) Ruro, Inc. (Booth 312) Better science begins with better samples. Precision Bioservices will streamline Headquartered in the heart of Maryland’s Bio Corridor, RURO develops and your testing through preparation and pre-qualification of your biological provides the most modern information management software solutions to more samples. Our quality management system and procedural consistency ensure than a thousand laboratories worldwide. RURO systems can decrease staff time reliable and meaningful results. requirements for data entry, compilation and reporting by more than a third, Accelerate your research through our custom offerings: and reduce user input errors by up to 97%. RURO is Laboratory Information Bliss™. For more information please visit RURO online at www.RURO.com • Collection kit design and production • Biological sample processing

www.isber.org Walt Disney World Swan and Dolphin Resort 2014 Orlando, Florida, USA • May 20 – 24, 2014

Scinomix Inc. (Booth 417) They use less than half the energy of any competing unit, have unmatched temperature stability, can be plugged into any electrical outlet worldwide and Scinomix is a leading provider of laboratory automation systems to customers in are manufactured in the USA. At ISBER Stirling Ultracold will exhibit the award the Life Science industry. Our standard line of automated tube and plate labelers winning 27 cu. ft. SU780U freezer. will give you significant walk-away time and increase productivity and efficiency in the lab. In addition to offering our own fully automated systems, we also Taylor-Wharton (Booth 301, 400) integrate many of our products with other manufacturers’ instrumentation to provide complete solutions for our customers. Based in Minnetonka, MN, Taylor-Wharton Cryogenics LLC manufactures state- of-the-art CryoScience by Taylor-Whartontm equipment ranging from 1.5 liters Sequenom Bioscience (Booth 118a) to the largest LABS freezer that holds up to 94,200 vials. A complete line of CryoScience laboratory inventory control systems and accessories are available. Sequenom Bioscience offers the MassARRAY® System, a highly sensitive, With worldwide operations and manufacturing facilities, Taylor-Wharton also quantitative method for nucleic acid detection via MALDI-TOF mass produces a complete line of liquid cylinders, Microbulk and bulk tank storage spectrometry. The MassARRAY® System enables rapid assay development for systems up to 110,000 gallons. For more information on the complete line of interrogating anywhere from tens to hundreds of biomarkers at a low cost point Taylor-Wharton products, call U.S. customer service at 1-251-443-8680 or visit per sample. Take advantage of Sequenom Bioscience’s family of research use www.taylorwharton.com. only somatic mutation panels to accelerate translational and clinical research. Select tumor-specific lung cancer and melanoma research panels or the new OncoFOCUS™ Panel for targeted hot spot profiling in EGFR, KRAS, BRAF, and Tecan (Booth 217) NRAS. Visit booth #118a. Tecan is a leading global provider of laboratory instruments and solutions in biopharmaceuticals, forensics, and clinical diagnostics. The company specializes So-Low Environmental Equipment Co., Inc. (Booth 106) in the development, production and distribution of instruments and automated workflow solutions for laboratories in the life sciences sector. Since 1959, So-Low has manufactured Ultra-Low Temperature Freezers for research, storage, and industrial needs. We also supply laboratory freezers, Tecan offers fully automated solutions for pre-analytical sample handling based refrigerators, undercounter freezers, and undercounter refrigerators for many on a compact and versatile platform. The Freedom EVO®-based workstation is a different applications. modular, front-end automation system with the flexibility to fit into your existing laboratory workflow, taking care of the most labor-intensive and error-prone Professionals in 122 countries, all over the world, have recognized the procedures, including sample sorting, sample volume inspection, centrifugation, dependability and efficiency of So-Low Ultra-Low Temperature Freezers and decapping and sample aliquoting into plates. Refrigerators. Our goal is to provide a level of quality construction, reliability and value unequaled anywhere in the world for our customers. Thermo Scientific (Booth 409) Starlims (Booth 103) Thermo Scientific is the premier partner in ensuring the sample quality, STARLIMS an Abbott Company, with over 25 years of experience, offers a highly reliability, and traceability required by biobanks and biorepositories. We deliver flexible and configurable genetics module, completely integrated with our the software, equipment, consumables, reagents, and services to provide the unified LIMS platform to automate and harmonize your laboratory processes. end-to-end solution required for today’s rapidly changing organizations. Our STARLIMS can process large volumes of data, facilitate regulatory compliance integrated turnkey biobanking portfolio encompasses sample preparation and and streamline the sharing of your laboratory data. storage to liquid handling equipment, cold storage devices, to Laboratory Information Systems (LIMS). www.thermoscientific.com/biobankingresources STARLIMS is a comprehensive solution designed to increase operational efficiency while improving the quality of your specimens and sample data by offering the Automated Tools, Electronic Tracking and Full Scalability. Customers Titian Software (Booth 214) depend on the ability to manage and distribute high-quality specimens. Founded in 1999, Titian Software specializes in sample management, offering Stirling Ultracold (Booth 415) software products and consultancy services for improving the efficiency, throughput and data integrity of one’s sample libraries. Its industry-renowned Stirling Ultracold manufactures and sells the world’s highest performing ultra Mosaic™ software optimizes the storage, processing, tracking, and ordering of low temperature freezers. These units are cooled with an environmentally small and large molecule sample collections. The Mosaic product suite can be friendly energy efficient Stirling engine instead of cascade compressors. a solution for single or multi-site organizations and is currently used by 13 of

International Society for Biological and Environmental Repositories ISBER 2014 Scientific Program

the Top 20 bio-pharma companies. With increasing worldwide demand, Titian management and biobanking. TWD prides itself with superior customer services Software has presence in Europe, the United States and the Far East to provide and highest quality of products. its customers with local expertise and support. Vaisala, Inc. (Booth 414a) TTP Labtech (Booth 207, 306) Vaisala provides high-performance monitoring, measurement and validation TTP Labtech, a UK life science company provides high quality, robust and systems for regulated and GxP environments. With fail-safe monitoring and innovative automated laboratory equipment instrumentation to the life scientist alarming of humidity, temperature, CO2, differential pressure and more, Vaisala to create process efficiencies. It offers products that minimise assay volumes, provides the most reliable solutions and support worldwide. Vaisala’s Continuous reduce handling costs in its three product areas; sample management, liquid Monitoring Systems deliver gap-free data and industry-best accuracy, while the handling and cell imaging. Vaisala Cold Chain solutions reduce the risk of ruined or adulterated vaccines, pharmaceuticals, biologics and other perishable products during distribution. Biobanking is an integral part of sample management. TTP Labtech provides a Website: www.vaisala.com high-density biostore (arktic®) for compact and automated -80°C storage of up to 95,000 samples with full sample tracking and rapid retrieval which can fit neatly into a bench-sized space. Wheaton (Booth 415a)

Throughout its 125 year history, WHEATON® has been dedicated to supporting TWD TradeWinds, Inc. (Booth 115) scientific advances and discovery by providing innovative solutions forthe laboratory research, diagnostic and specialty pharmaceutical industries. The TWD is the industry leader in permanent barcode technologies. With company’s expertise in plastic and glass containers coupled with a wide manufacturing facilities centrally located in the United States, TWD provides a selection of closure systems and custom solutions ensures the secure storage wide variety of permanently barcoded glass and plastic sample vials, serving the and delivery of science’s most sensitive materials and precious specimens. pharmaceutical and life science research community, particularly in compound

www.isber.org Perfectly Preserved. Hamilton guarantees it. Hamilton’s ultra-low temperature automated sample storage solutions maintain the value of your samples. Our products are used for storage of biological samples and compounds for biobanking, forensic, and drug discovery applications.

Visit us at Booth #212

HST0034-1 ISBER Ad-BlackWhite r2.indd 1 2/27/14 1:39 PM

Speakers & Chair Index Acker J...... 28 Furuta K...... 28 Malin B...... 30 Shea K...... 24, 27 Agrawal L...... 28 Gan R...... 24 Marko-Varga G...... 28 Shi T...... 30 Akervall J...... 28 Göransson C...... 26 Masui T...... 30 Siefers H...... 28 Albert M...... 28 Gunter E...... 24 McNally J...... 29 Siemon J...... 24 Aparicio S...... 24 Henderson M...... 24, 25 Mendy M...... 28, 29 Silver S...... 27 Barnes M...... 30 Hostetter G...... 27 Minegishi N...... 28 Simeon-Dubach D...... 25 Bartels P...... 26, 28 Hubel A...... 28 Moors A...... 28 Spindler R...... 26 Becker P...... 26 Hudson M...... 27 Morrin H...... 30 Steegers C...... 28, 29 Betsou F...... 24, 29 Isasi R...... 29 Mullins P...... 26 Tassé A...... 29, 30 Black J...... 24 Kamlage B...... 26 Nelsen A...... 29 Thomson B...... 25 Blackburn H...... 26 Karvonen C...... 29 Olson J...... 27 Van Veen E...... 27, 30 Bledsoe M...... 29, 30 Khlebnyy E...... 28 Posevitz-Fejfár A...... 27 Vaught J...... 25 Brockton N...... 29 Kirillova E...... 28 Prokopiev I...... 28 Wagner E...... 28 Bromley R...... 25 Kofanova O...... 27, 28 Rajasekhar V...... 27 Warner A...... 29, 30 Brooks A...... 29 Kozlakidis Z...... 24, 28 Rasooly R...... 27 Watson P...... 25 Carpenter J...... 27 Labib R...... 27 Riegman P...... 25 Winkler E...... 27 Chisholm R...... 24 Lawlor R...... 29 Robson K...... 29 Wolf M...... 24 Cong X...... 27 Ledbetter D...... 24 Roehrl M...... 27 Woods E...... 24 De Blasio P...... 26 Lee M...... 26 Rondot Radío P...... 29 Yeung T...... 28 Djaballah H...... 24 Lehman R...... 28 Rosati K...... 30 Zaayenga A...... 26 Doms L...... 26 Lermen D...... 28 Roy M...... 28 Zhang Y...... 24, 27 Dvoskin R...... 27 Lewandowski D...... 26 Salvaterra E...... 29 Ehmke E...... 26 Litton J.E...... 25, 29 Sargsyan K...... 28 Frey M...... 29 Lunshof J...... 30 Schacter B...... 24, 25 Poster Index Abdelhalim I...... RM 10 Gorman J...... RAT 01 Mason D...... HSR 34, RM 22 Shin S...... BRS 13 Acker J...... BRS 29 Guan P...... RM 13 Matharoo-Ball B...... HSR 32 Sieffert N...... HT 03 Aibaidula A...... HSR 12 Hall A...... HSR 60 Matzke L...... RM 15 Simeon-Dubach D...... RM 04, RM 11 Ammerlaan W...... RS 13 Hall S...... RS 03 McNally J...... HT 02 Sprigg N...... HSR 16 An J...... EPSR 05 Hamot G...... BRS 05 Mews A...... RM 19 Steinfelder E...... RM 23 Bahunde F...... BRS 19 Heaton R...... BRS 24 Miranda L...... RS 11 Sun M...... BRS 16, HSR 49 Ball L...... RM 27 Henderson M...... ELSI 02 Monovich L...... RM 40 Swanepoel C...... HSR 43 Barnes M...... RAT 03 Hodgkinson V...... BRS 14 Mook L...... RM 16 Tarling T...... HSR 17 Barr T...... RS 06 Hogen S...... RM 26 Morgenweck W...... RM 06 Tarn C...... HSR 61 Betsou F...... HT 04, RS 19 Hoskins J...... BRS 31 Noyes L...... RS 20 Thomson B...... RM 17 Bowles D...... HSR 50 Huang C...... HSR 36 Nussbeck S...... RS 01 Tolay S...... HSR 19 Brooks A...... RS 07 Jewell S...... HSR 62 Odeh H...... RM 30 Tran A...... RM 28 Campos A...... HSR 11 Jin H...... RS 09 Pang J...... BRS 34 Valley D...... RS 21 Carithers L...... HSR 28 Karvonen C...... HT 01 Pereira S...... ELSI 10 Valyi-Nagy K...... BRS 26 Carpenter J...... RM 32 Kelly V...... RS 16 Ponko S...... RM 20 Van Rooyen B...... ELSI 05 Chaffin D...... RS 15 Kofanova O...... RS 10 Prodanovic Z...... HSR 48 Verna N...... RS 08 Chakrabarty R...... RM 05 Kollis S...... BRS 18 Pruetz B...... HSR 40 VonMenchhofen Z...... RM 29 Chu P...... HSR 21 Kozlakidis Z...... BRS 01 Pugh R...... EPSR 04 Wagner E...... RM 09 Clark L...... BRS 32 Kruckeberg K...... RM 21 Pumplun E...... RS 22 Wang C...... HSR 53 Cohen Y...... BRS 17 Kwon H...... HSR 05 Rao A...... BRS 12 Wang W...... RM 31 Cui D...... RS 18 Labib R...... RAT 05 Rasooly R...... HSR 14 Wang Y...... RM 34, RS 12 D’Angelo K...... ELSI 09 Larson D...... HSR 46 Rau M...... HSR 01 Warth R...... RM 41 De Blasio P...... BRS 06, HSR 26 Lawlor R...... BRS 21 Ravid R...... BRS 28 Wease K...... RM 24 Demchok J...... HSR 31 Lazaris A...... HSR 33 Raymond E...... HSR 20, RM 03 White C...... BRS 30 Donaldson M...... BRS 22 Lee J...... BRS 15 Resch Z...... HSR 08 Wiles K...... RM 08, RS 17 Dore J...... RAT 02 Li H...... HSR 18 Robb J...... HSR 02 Withers S...... BRS 23 Dowst H...... RM 07 Li T...... BRS 04 Robson K...... HSR 47 Wong G...... BRS 36 Driga A...... RM 02 Li X...... RM 35 Rohrer D...... RM 33 Wu S...... BRS 02, BRS 03 Dry S...... HSR 45 Lin A...... RS 02 Rosenfeld G...... HSR 07 Ye Q...... HSR 38 Duma B...... RM 12 Liu A...... HSR 06 Rubinstein Y.R...... BRS37 Yeadon T...... RM 39 Ellis H...... RM 01 Liu L...... HSR 29, RM 14 Rush A...... HSR 13 Yin L...... HSR 22 Ezzat S...... HSR 58 Liu S...... HSR 42 Salman A...... ELSI 04 Yuan M...... BRS 07 Furuta K...... HSR 54 Loffredo C...... HSR 52 Sargsyan K...... RAT 06 Zhang X...... HSR 37 Galbraith J...... HSR 27 Mandt R...... RM 36, RM 38 Sawyer S...... HSR 64 Zhao Y...... HSR 09 Gao Y...... HSR 04 Mann S...... HSR 15 Sharp A...... RS 23 Zhou H...... HSR 23, HSR 25 Gao Z...... RAT 04 Margossian A...... HSR 51 Shea K...... HSR 39 Zhou J...... HSR 56, HSR 57 Geddes T...... RS 04 Martin L...... RS 14 Shin H...... BRS 10

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