Apathy in Parkinson's Disease: Clinical Features, Neural Substrates, Diagnosis, and Treatment
Article Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment PAGONABARRAGA, Javier, et al. Reference PAGONABARRAGA, Javier, et al. Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment. The Lancet Neurology, 2015, vol. 14, no. 5, p. 518-531 DOI : 10.1016/S1474-4422(15)00019-8 PMID : 25895932 Available at: http://archive-ouverte.unige.ch/unige:95955 Disclaimer: layout of this document may differ from the published version. 1 / 1 Review Apathy in Parkinson’s disease: clinical features, neural substrates, diagnosis, and treatment Javier Pagonabarraga, Jaime Kulisevsky, Antonio P Strafella, Paul Krack Lancet Neurol 2015; 14: 518–31 Normal maintenance of human motivation depends on the integrity of subcortical structures that link the prefrontal Movement Disorders Unit, cortex with the limbic system. Structural and functional disruption of diff erent networks within these circuits alters the Neurology Department, maintenance of spontaneous mental activity and the capacity of aff ected individuals to associate emotions with complex Sant Pau Hospital and stimuli. The clinical manifestations of these changes include a continuum of abnormalities in goal-oriented behaviours Biomedical Research Institute, Barcelona, Spain known as apathy. Apathy is highly prevalent in Parkinson’s disease (and across many neurodegenerative disorders) and (J Pagonabarraga PhD, can severely aff ect the quality of life of both patients and caregivers. Diff erentiation of apathy from depression, and Prof J Kulisevsky PhD); discrimination of its cognitive, emotional, and auto-activation components could guide an individualised approach to the Universitat Autònoma de treatment of symptoms. The opportunity to manipulate dopaminergic treatment in Parkinson’s disease allows Barcelona, Barcelona, Spain (J Pagonabarraga, researchers to study a continuous range of motivational states, from apathy to impulse control disorders.
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