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WO 2017/066488 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2017/066488 A l 2 0 April 2017 (20.04.2017) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/485 (2006.01) A61P 25/04 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/5415 (2006.01) A61P 1/08 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US20 16/0569 10 HN, HR, HU, ID, IL, EST, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 13 October 2016 (13.10.201 6) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/240,965 13 October 2015 (13. 10.2015) US (84) Designated States (unless otherwise indicated, for every 62/300,014 25 February 2016 (25.02.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: CHARLESTON LABORATORIES, INC. -
Additional Materials
Truth Quality 11/15/2019 Controlled Substances Board: Law Service Enforcement Hearing - Crime Lab Presentation Mission: to promote excellence in analysis, training and service to the community and our Lead organization with integrity and uncompromising CS Unit Trends in 2019 quality. Character Science Integrity Division of Forensic Sciences Wisconsin State Crime Laboratories History Sandy Koresch Advancements Training Experts Vision: to search for the truth through science and to lead and shape the advancement of forensic science. Analysis Competence Wisconsin State Crime WSCLI Laboratories Milwaukee serves 8 Southeastern County Area Madison serves 24 Southern County Area Wausau serves 40 Northern County Area Wisconsin State Crime Laboratories 2 Controlled Substances Unit – Analyze evidence with suspected controlled substances submitted by law enforcement agencies – Most evidence is related to felony charges; some misdemeanors – Our focus is to identify controlled substances under Wisconsin Statute 961; other drug related substances may be indicated/identified – Types of evidence can range from powders, plant material, liquids, and tablets to drug paraphernalia and food items Wisconsin State Crime Laboratories 3 NFLIS DATA National Forensic Laboratory Information System https://www.nflis.deadiversion.usdoj.gov/NFLISHome.aspx Wisconsin State Crime Laboratories 4 Emerging Threat Report -DEA https://ndews.umd.edu/resources/dea-emerging-threat-reports Wisconsin State Crime Laboratories 5 NPS Discovery Center for Forensic Research and Education (CFRE) -Includes seized drug samples and biological samples https://www.npsdiscovery.org/ Wisconsin State Crime Laboratories 6 NMS/CFRE Webinar Wisconsin State Crime Laboratories 7 Crime Lab Data • Data affected by submission guidelines and law changes (hemp/marijuana) • Data includes items analyzed vs. -
NFLIS-Drug Selected Substance List
2017-2020 NFLIS-Drug Substance List (Sorted by Date) Date Added NFLIS Substance Name Synonyms Chemical Name Structure InChI Formula to NFLIS- Drug InChI=1S/C16H20BrN/ c17-14-1-3-15(4-2-14)18-16-12-6-10-5-11 Bromantane ladasten N-(4-bromophenyl)adamantan-2-amine C16H20BrN 12/7/20 (8-12)9-13(16)7-10/h1-4,10-13,16,18H, 5-9H2 InChI=1S/C21H29FN2O3/ c1-4-27-21(26)19(15(2)3)23-20(25)17-14- ethyl 2-(1-(5-fluoropentyl)-1H-indole-3-carboxamido)-3- 5F-EMB-PICA EMB-2201; 5-fluoro-EMB-PICA 24(13-9-5-8-12-22)18-11-7-6-10-16(17)18 C21H29FN2O3 11/12/20 methylbutanoate /h6-7,10-11,14-15,19H, 4-5,8-9,12-13H2,1-3H3,(H,23,25) InChI=1S/C20H27FN2O3/ c1-20(2,3)17(19(25)26-4)22-18(24)15-13- methyl 2-(1-(4-fluorobutyl)-1H-indole-3- 4F-MDMB-BUTICA 4-fluoro-MDMB-BUTICA; 4F-MDMB-BICA 23(12-8-7-11-21)16-10-6-5-9-14(15)16/ C20H27FN2O3 10/23/20 carboxamido)-3,3-dimethylbutanoate h5-6,9-10,13,17H,7-8,11-12H2,1-4H3,(H, 22,24) InChI=1S/C10H14BrNO2/ 4-methoxy-6-[(1E)-2-phenylethenyl]-5,6-dihydro-2H- 2Br-4,5-Dimethoxyphenethylamine 2-bromo-4,5-dimethoxyphenethylamine c1-13-9-5-7(3-4-12)8(11)6-10(9)14-2/ C10H14BrNO2 10/2/20 pyran-2-one h5-6H,3-4,12H2,1-2H3 InChI=1S/C16H22FNO/ 4-fluoro-3-methyl-alpha-PVP; 4F-3-methyl-alpha- c1-3-6-15(18-9-4-5-10-18)16(19)13-7-8-1 4F-3-Methyl-alpha-PVP 4-fluoro-3-methyl-alpha-pyrrolidinopentiophenone C16H22FNO 10/2/20 pyrrolidinovalerophenone 4(17)12(2)11-13/h7-8,11,15H, 3-6,9-10H2,1-2H3 InChI=1S/C21H26N4O3/ N,N-diethyl-2-[2-(4-methoxybenzyl)-5-nitro-1H- c1-4-23(5-2)12-13-24-20-11-8-17(25(26)2 Metonitazene C21H26N4O3 9/15/20 benzimidazol-1-yl]ethanamine -
ADVANCED RELEASE EMCDDA Technical Report on the New Psychoactive Substance N,N- Diethyl-2-[[4-(1-Methylethoxy)Phenyl]Methyl]-5-N
ADVANCED RELEASE EMCDDA technical report on the new psychoactive substance N,N- diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H- benzimidazole-1-ethanamine (isotonitazene) Explanatory note: In the interests of public health protection the EMCDDA is releasing this report before formal copy editing and page layout in the EMCDDA house style. The final report will be available on the EMCDDA website in due course. Authors: Michael Evans-Brown1, István Ujváry2, Joanna De Morais1, Rachel Christie1, Anabela Almeida1, Rita Jorge1, Ana Gallegos1, Roumen Sedefov1 1European Monitoring Centre for Drugs and Drug Addiction, Praça Europa 1, Cais do Sodré, 1249–289 Lisbon, Portugal 2iKem BT, Búza u. 32, Budapest 1033, Hungary Recommended citation: EMCDDA (2020), EMCDDA technical report on the new psychoactive substance N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H- benzimidazole-1-ethanamine (isotonitazene), EMCDDA, Lisbon. © European Monitoring Centre for Drugs and Drug Addiction, 2019 Praça Europa 1, Cais do Sodré, 1249–289 Lisbon, Portugal Tel: +351 211210200 Email: [email protected] Web: www.emcdda.europa.eu 1 Purpose The purpose of this technical report to provide an analyses of the available information on N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H-benzimidazole-1-ethanamine (commonly known as isotonitazene), an opioid analgesic that has recently emerged on the drug market in Europe, to support a risk assessment of the substance that has been requested by the European Commission in accordance with Article 5c of Regulation (EC) No 1920/2006 (as amended). Parts of this report were prepared under an EMCDDA contract (ref. -
Infographics About Synthetic Opioids
UNODC LEADING THE INTERGRATED GLOBAL RESPONSE TO THE OPIOID CRISIS P I L L A R 1 P I L L A R 2 P I L L A R 3 P I L L A R 4 P I L L A R 5 I N T E R N A T I O N A L L A W S T R E N G T H E N I N G C O U N T E R E A R L Y W A R N I N G A N D R A T I O N A L P R E S C R I B I N G A N D S T R E N G T H E N I N G A N D S U P P O R T I N G E N F O R C E M E N T O P E R A T I O N S N A R C O T I C C A P A C I T Y A N D T R E N D A N A L Y S I S A C C E S S T O O P I O I D S P R E V E N T I O N A N D T R E A T M E N T T O D I S R U P T T R A F F I C K I N G I N T E R N A T I O N A L C O O P E R A T I O N IDENTIFYING THE MOST PREVELANT, PERSISTANT AND HARMFUL SYNTHETIC OPIOIDS U N O D C 282 90 E A R L Y TOXICOLOGY COLLABORATING IN COUNTRIES W A R N I N G INFORMED THREATS LABORATORIES A D V I S O R Y ASSESSMENTS PHARMACOLOGICAL INFORMATION L A B O R A T O R I E S A N D D A T A P O I N T S L A B O R A T O R I E S D A T A P O I N T S G L O B A L S M A R T U P D A T E S 21,400+ 120 DATA POINTS FROM COUNTRIES SYNTHETIC SEDATIVE 74 OPIOIDS HYPNOTICS REPORTED MIRRORING TO UNODC SYNTHETIC E A R L Y OPIOID TRENDS W A R N I N G A D V I S O R Y B Y 2019 131% IN THE LAST * * 3 Y E A R S Note: * 2019 data collection not finalized LIST OF SYNTHETIC OPIOIDS REPORTED TO THE UNODC EWA FROM 2009-2019 S C H E D U L E D 2-Fluorofentanyl Furanylfentanyl 4-Fluorobutyrfentanyl Methoxyacetylfentanyl 4-Fluoroisobutyrfentanyl MT-45 S C H E D U L E I Acrylfentanyl Ocfentanil ( 1 9 6 1 ) AH-7921 Tetrahydrofuranylfentanyl Butyrfentanyl U-47700 S C H E D U L E I & I V Cyclopropylfentanyl -
Eu Early Warning System Situation Report
EU EARLY WARNING SYSTEM SITUATION REPORT Situation report 1 — June 2020 SITREP ID: EU-EWS-SITREP-2020-0001 Issued by: EMCDDA Date issued: 16/06/2020 Transmitted by: Action on New Drugs Sector, EMCDDA Recipients: Early Warning System Network Contents 1. Purpose 2 2. General update of the NPS situation 2 3. Operational matters 7 4. Subject focus: Potential impact of the COVID-19 pandemic on the drug markets and risks to people who use drugs 8 5. Update from the national early-warning systems 11 6. Publications and resources of interest 11 7. New psychoactive substances notified in 2020 — provisional list, 1 January–16 June 2020 13 8. References 15 EU-EWS-SITREP-2020-0001 1 of 16 1. Purpose The purpose of this situation report is to: provide a summary of recent information reported to the EU Early Warning System, including formal notifications and other important signals; highlight important operational issues; and, provide other resources identified by the EMCDDA. This report may contain information that might be under verification. The information and resources in this report are intended to strengthen situational awareness within the Network, as well as to help the Network to prepare for, respond to, and recover from public health and social threats caused by new psychoactive substances (NPS) and other substances of interest. A specific focus of this report is to: • highlight recent resources that examine the potential impact of the COVID-19 pandemic on the drug markets and risks to people who use drugs; and, • request that the Network expedite reporting of any event, especially those related to the pandemic, that you consider may have a potential high impact on public health. -
Global Overview on NPS, Synthetic Opioids and Emerging Issues Content
UNODC Global overview on NPS, synthetic opioids and emerging issues Content • New psychoactive substances globally and in Latin America and the Caribbean • Synthetic opioids • Emerging issues Global emergence of NPS The boundaries and names shown and the designations in this document do not imply official endorsement or acceptance by the United Nations. Dashed lines represent undetermined boundaries. The dotted line represents approximately the Line of Control in Jammu and Kashmir agreed upon by India and Pakistan. The final status of Jammu and Kashmir has not yet been agreed upon by the parties. The final boundary between the Republic of Sudan and the Republic of South Sudan has not yet been determined. A dispute exists between the Governments of Argentina and the United Kingdom of Great Britain and Northern Ireland concerning sovereignty over the Falkland Islands (Malvinas). Number of NPS reported annually, 2009-2020 Over 1000 individual NPS reported by 126 member States and territories Source: UNODC Early Warning Advisory on NPS NPS reported in the region 2015-2019* 80 70 60 50 40 30 Number ofsubstances Number 20 10 0 2015 2016 2017 2018 2019* Synthetic cannabinoid receptor agonists Dissociatives Classic hallucinogens Plant-based substances Sedatives/hypnotics Stimulants Synthetic opioids Others Source: UNODC, Early Warning Advisory on new psychoactive substances. *Note: Data collection for 2019 is preliminary. NPS hallucinogens trends: NBOMe- vs 2C-compounds Source: UNODC, Early Warning Advisory on new psychoactive substances. Note: -
New Psychoactive Substances (NPS)
New Psychoactive Substances (NPS) LGC Quality Reference ISO 9001 ISO/IEC 17025 ISO Guide 34 materials GMP/GLP ISO 13485 2019 ISO/IEC 17043 Science for a safer world LGC offers the most extensive and up-to-date range of New LGC is a global leader in Psychoactive Substances (NPS) measurement standards, reference materials. reference materials, laboratory services and proficiency testing. With 2,600 professionals working When you make a decision using The challenge The LGC response We are the UK’s in 21 countries, our analytical our resources, you can be sure it’s designated National measurement and quality control based on precise, robust data. And New Psychoactive Substances In response to the ever-expanding LGC Standards provides the widest Measurement services are second-to-none. together, we’re creating fairer, safer, (NPS) continue to be identified, range of NPS being developed, LGC range of reference materials Institute for chemical more confident societies worldwide. and it appears that moves by the has produced a comprehensive available from any single supplier. and bioanalytical As a global leader, we provide the United Nations and by individual range of reference materials that We work closely with leading widest range of reference materials lgcstandards.com countries to control lists of meet the rapidly changing demands manufacturers to provide improved measurement. available from any single supplier. named NPS may be encouraging of the NPS landscape. Many of access to reference materials, the development of yet further these products are produced under with an increasingly large range variants to avoid these controls. the rigorous quality assurance of parameters, for laboratories standards set out in ISO Guide 34. -
Softember Abstracts
SOFTEMBER ABSTRACTS SOFTEMBER POSTER ABSTRACTS...............................................2-56 SOFTEMBER PLATFORM ABSTRACTS .................................... 57-127 SOFTEMBER POSTER ABSTRACTS A 4-Year Systematic Analysis of Commercial E-liquids: The Evolution of G.R.A.S. to Inhaled Toxins Authors and Affiliations: Alaina K. Holt, B.S.*(1), Justin L. Poklis, B.S.(2), and Michelle R. Peace, Ph.D.(1) (1) Department of Forensic Science and (2) Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA Background/Introduction: Electronic cigarettes (e-cigs) were originally developed as an alternate method for nicotine delivery. The e-liquids are made of ratios of humectant formulations, pharmacologically active ingredients, flavoring chemicals, volatiles, preservative chemicals, and other “enhancing” chemicals. E-cigs have also been adopted for drugs other than nicotine (DOTN), including cannabidiol (CBD) and tetrahy- drocannabinol (THC). E-liquid manufacturers use chemicals that are generally regarded as safe (GRAS) for oral consumption. The FDA promulgated regulations to govern e-cigarette devices and e-liquids in May 2016, yet product approval deadlines are May 2020. The flavoring bans that were instituted in January 2020 only govern pod-based products. E-liquid formulations for re-filling e-cigarettes have not been heavily scrutinized by regulatory agencies, under the auspice that only pod-based products are most likely to be used by children. E-liquid formulations have evolved as a result of vaping preferences, public health sentiment, and looming regulations. Quality assurance and product safety remain inadequate, demonstrated recently by e-cigarette or vaping product associated lung injury (EVALI). Objectives: The objective of this study was to evaluate the chemical composition of e-liquids and to establish over time humectant formulations, pharmacologically active ingredients, flavoring chemicals, volatiles, preservative chemicals, and other “enhancements”. -
12 Step Critique Example2 Step Critique Example Example2 Step Critique
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European Drug Report 2020: Key Issues Summary, Publications Office of the European Union, Luxembourg
EN KEY ISSUES 2020 KEY ISSUES 2020 I Legal notice This publication of the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) is protected by copyright. The EMCDDA accepts no responsibility or liability for any consequences arising from the use of the data contained in this document. The contents of this publication do not necessarily reflect the official opinions of the EMCDDA’s partners, any EU Member State or any agency or institution of the European Union. This report is availale in Bulgarian, Spanish, Czech, Danish, German, Estonian, Greek, English, French, Croatian, Italian, Latvian, Lithuanian, Hungarian, Dutch, Polish, Portuguese, Romanian, Slovak, Slovenian, Finnish, Swedish, Turkish and Norwegian. All translations were made by the Translation Centre for the Bodies of the European Union. Luxembourg: Publications Office of the European Union, 2020 © European Monitoring Centre for Drugs and Drug Addiction, 2020 Reproduction is authorised provided the source is acknowledged. Recommended citation: European Monitoring Centre for Drugs and Drug Addiction (2020), European Drug Report 2020: Key Issues Summary, Publications Office of the European Union, Luxembourg. Print ISBN 978-92-9497-526-3 doi: 10.2810/029425 TD-04-20-439-EN-C PDF ISBN 978-92-9497-503-4 doi: 10.2810/759563 TD-04-20-439-EN-N Recommended citation: European Monitoring Centre for Drugs and Drug Addiction (2020), European Drug Report 2020: Key Issues, Publications Office of the European Union, Luxembourg. YEARS OF MONITORING 1995–2020 Praça Europa 1, Cais -
In Vitro Functional Characterization of a Panel of Non-Fentanyl Opioid New Psychoactive Substances Authors
biblio.ugent.be The UGent Institutional Repository is the electronic archiving and dissemination platform for all UGent research publications. Ghent University has implemented a mandate stipulating that all academic publications of UGent researchers should be deposited and archived in this repository. Except for items where current copyright restrictions apply, these papers are available in Open Access. This item is the archived peer-reviewed author-version of: Title: In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances Authors: Vandeputte, M., Cannaert, A., & Stove, C. In: ARCHIVES OF TOXICOLOGY, 94(11), 3819–3830, 2020 Optional: https://doi.org/10.1007/s00204-020-02855-7 To refer to or to cite this work, please use the citation to the published version: Vandeputte, M., Cannaert, A., & Stove, C. (2020). In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances. ARCHIVES OF TOXICOLOGY, 94(11), 3819–3830. https://doi.org/10.1007/s00204-020-02855-7 In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances Marthe M. Vandeputte, Annelies Cannaert, Christophe P. Stove* Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium ORCID 0000-0002-1431-441X (MV) 0000-0002-8654-1371 (AC) 0000-0001-7126-348X (CS) Corresponding author: Christophe P. Stove [email protected] Abstract The landscape of new psychoactive substances (NPS) is constantly evolving, with new compounds entering the illicit drug market at a continuous pace. Of these, opioid NPS form a threat given their high potency and prevalence. Whereas previously, the use of fentanyl and fentanyl derivatives was the main point of attention, legislations have reacted accordingly, which may have been a driving force towards the (ab)use of alternative µ-opioid receptor (MOR) agonists.