European Drug Report 2020: Trends and Developments
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Broadband Coverage 97% Fixed and Mobile Broadband
Connectivity Broadband market developments in the EU Digital Economy and Society Index Report 2019 Connectivity The Digital Economy and Society Index (DESI) is a composite index that summarises relevant indicators on Europe’s digital performance and tracks the progress of EU Member States in digital competitiveness. The five dimensions of the DESI 1 Connectivity Fixed broadband, mobile broadband, fast and ultrafast Finland, Sweden, the Netherlands and Denmark, have the most broadband and prices advanced digital economies in the EU followed by the UK, 2 Human capital Internet user skills and advanced skills Luxembourg, Ireland and Estonia. 3 Use of internet Citizens' use of internet services and online transactions Bulgaria, Romania, Greece and Poland have the lowest scores on the index. 4 Integration of Business digitisation and e-commerce digital technology 5 Digital public e-Government and e-health services Digital Economy and Society Index (DESI) 2019 80 1 Connectivity 2 Human capital 3 Use of internet services 4 Integration of digital technology 5 Digital public services 70 60 50 40 30 20 10 0 FI SE NL DK UK LU IE EE BE MT ES DE AT EU LT FR SI LV CZ PT HR SK CY HU IT PL EL RO BG Source: DESI 2019, European Commission DESI Report 2019 – Connectivity 2 In Connectivity, Denmark had the highest score, followed by Luxembourg, the Netherlands, Sweden and Finland. Greece, Croatia and Lithuania had the weakest performance in this dimension of the DESI. Connectivity indicators in DESI 2019 EU The connectivity dimension looks at both the demand and the supply side of 1a1 Fixed broadband coverage 97% fixed and mobile broadband. -
Report on a Novel Emerging Class of Highly Potent Benzimidazole NPS Opioids: Chemical and in Vitro Functional Characterization of Isotonitazene
Received: 29 August 2019 Revised: 12 November 2019 Accepted: 13 November 2019 DOI: 10.1002/dta.2738 RESEARCH ARTICLE Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene Peter Blanckaert1† | Annelies Cannaert2† | Katleen Van Uytfanghe2 | Fabian Hulpia3 | Eric Deconinck4 | Serge Van Calenbergh3 | Christophe Stove2 1Scientific Direction Epidemiology and Public Health, Section Lifestyle and Chronic Diseases, Abstract Belgian Early Warning System Drugs This paper reports on the identification and full chemical characterization of (BEWSD), Sciensano, Brussels, Belgium isotonitazene (N,N-diethyl-2-[5-nitro-2-({4-[(propan-2-yl)oxy]phenyl}methyl)-1H-ben- 2Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical zimidazol-1-yl]ethan-1-amine), a potent NPS opioid and the first member of the Sciences, Ghent University, Ghent, Belgium benzimidazole class of compounds to be available on online markets. Interestingly, 3Laboratory for Medicinal Chemistry, Department of Pharmaceutics, Faculty of this compound was sold under the name etonitazene, a structural analog. Identifica- Pharmaceutical Sciences, Ghent University, tion of isotonitazene was performed by gas chromatography mass spectrometry Ghent, Belgium (GC–MS) and liquid chromatography time-of-flight mass spectrometry (LC-QTOF- 4Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health MS), the latter identifying an exact-mass m/z value of 411.2398. All chromatographic Products, Sciensano, Brussels, Belgium data indicated the presence of a single, highly pure compound. Confirmation of the 1 13 Correspondence specific benzimidazole regio-isomer was performed using H and C NMR spectros- copy, after which the chemical characterization was finalized by recording Fourier- Christophe Stove, Laboratory of Toxicology, Department of Bioanalysis, Faculty of transform (FT-IR) spectra. -
Every Avenue Available Lessons from Monetary History for Tackling Climate Change
EVERY AVENUE AVAILABLE LESSONS FROM MONETARY HISTORY FOR TACKLING CLIMATE CHANGE Rens van Tilburg and Aleksandar Simić February 2021 Every Avenue Available “I WANT TO EXPLORE EVERY AVENUE AVAILABLE 2 IN ORDER TO COMBAT CLIMATE CHANGE” Christine Lagarde, president of the European Central Bank, July 2020 Sustainable Finance Lab Every Avenue Available 3 Utrecht, February 2021. The Sustainable Finance Lab (SFL https://sustainablefinancelab.nl/en) is an academic think tank whose members are mostly professors from different universities in the Netherlands. The aim of the SFL is a stable and robust financial sector that contributes to an economy that serves humanity without depleting its environment. To this end the SFL develops ideas and provides a platform to discuss them, thus bridging science and practice. This paper has been drafted by Rens van Tilburg, Director of the Sustainable Finance Lab at Utrecht University ([email protected]) and Aleksandar Simić, researcher of the SFL. The authors wish to thank Roben Kloosterman for his excellent research support and Alexander Barkawi, Simon Dikau, Maarten Kavelaars, Jens van ‘t Klooster, Cormac Petit, Rick van der Ploeg, Dirk Schoenmaker and Roland Uittenbogaard Sustainable Finance Lab for their comments. The views expressed in this publication are those of the authors and do not necessarily reflect those of all members of the Sustainable Finance Lab. This paper was commissioned by the Council on Economic Policies and supported by the European Climate Foundation. Every Avenue Available KEY TAKEAWAYS Insufficient action to limit climate change The costs of runaway climate change are much higher than those of limiting it. -
Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set
MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01 -
The Knowns and Unknowns of West Nile Virus in Europe: What Did We Learn from the 2018 Outbreak?
Expert Review of Anti-infective Therapy ISSN: 1478-7210 (Print) 1744-8336 (Online) Journal homepage: https://www.tandfonline.com/loi/ierz20 The knowns and unknowns of West Nile virus in Europe: what did we learn from the 2018 outbreak? Jeremy V Camp & Norbert Nowotny To cite this article: Jeremy V Camp & Norbert Nowotny (2020): The knowns and unknowns of West Nile virus in Europe: what did we learn from the 2018 outbreak?, Expert Review of Anti- infective Therapy, DOI: 10.1080/14787210.2020.1713751 To link to this article: https://doi.org/10.1080/14787210.2020.1713751 Accepted author version posted online: 08 Jan 2020. Published online: 14 Jan 2020. Submit your article to this journal Article views: 11 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=ierz20 EXPERT REVIEW OF ANTI-INFECTIVE THERAPY https://doi.org/10.1080/14787210.2020.1713751 REVIEW The knowns and unknowns of West Nile virus in Europe: what did we learn from the 2018 outbreak? Jeremy V Camp a and Norbert Nowotny a,b aViral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, Vienna, Austria; bDepartment of Basic Medical Sciences, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates ABSTRACT ARTICLE HISTORY Introduction: West Nile virus (WNV) is a mosquito-borne human and animal pathogen with nearly Received 28 October 2019 worldwide distribution. In Europe, the virus is endemic with seasonal regional outbreaks that have Accepted 7 January 2020 increased in frequency over the last 10 years. -
Pharmaceutical Appendix to the Tariff Schedule 2
Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9 -
WO 2017/066488 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2017/066488 A l 2 0 April 2017 (20.04.2017) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/485 (2006.01) A61P 25/04 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/5415 (2006.01) A61P 1/08 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US20 16/0569 10 HN, HR, HU, ID, IL, EST, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 13 October 2016 (13.10.201 6) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/240,965 13 October 2015 (13. 10.2015) US (84) Designated States (unless otherwise indicated, for every 62/300,014 25 February 2016 (25.02.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: CHARLESTON LABORATORIES, INC. -
Yearbook 2019/2020 Key Trends
YEARBOOK 2019/2020 KEY TRENDS TELEVISION, CINEMA, VIDEO AND ON-DEMAND AUDIOVISUAL SERVICES - THE PAN-EUROPEAN PICTURE → Director of publication Susanne Nikoltchev, Executive Director → Editorial supervision Gilles Fontaine, Head of Department for Market Information → Authors Francisco Javier Cabrera Blázquez, Maja Cappello, Laura Ene, Gilles Fontaine, Christian Grece, Marta Jiménez Pumares, Martin Kanzler, Ismail Rabie, Agnes Schneeberger, Patrizia Simone, Julio Talavera, Sophie Valais → Coordination Valérie Haessig → Special thanks to the following for their contribution to the Yearbook Ampere Analysis, Bureau van Dijk (BvD), European Broadcasting Union - Media Intelligence Service (EBU-M.I.S.), EURODATA-TV, LyngSat, WARC, and the members of the EFARN and the EPRA networks. → Proofreading Anthony Mills → Layout Big Family → Press and public relations Alison Hindhaugh, [email protected] → Publisher European Audiovisual Observatory 76 Allée de la Robertsau, 67000 Strasbourg, France www.obs.coe.int If you wish to reproduce tables or graphs contained in this publication please contact the European Audiovisual Observatory for prior approval. Please note that the European Audiovisual Observatory can only authorise reproduction of tables or graphs sourced as “European Audiovisual Observatory”. All other entries may only be reproduced with the consent of the original source. Opinions expressed in this publication are personal and do not necessarily represent the view of the Observatory, its members or of the Council of Europe. © European Audiovisual Observatory (Council of Europe), Strasbourg 2020 YEARBOOK 2019/2020 KEY TRENDS TELEVISION, CINEMA, VIDEO AND ON-DEMAND AUDIOVISUAL SERVICES - THE PAN-EUROPEAN PICTURE 4 YEARBOOK 2019/2020 – KEY TRENDS TABLE OF CONTENT INTRODUCTION 0 Six keywords for 2019 and, possibly, 2020 . -
Week 45, 4-10 November 2018 CDTR
COMMUNICABLE DISEASE THREATS REPORT CDTR Week 45, 4-10 November 2018 All users This weekly bulletin provides updates on threats monitored by ECDC. NEWS 33 000 people die every year due to infections with antibiotic-resistant bacteria The burden of infections due to bacteria resistant to antibiotics is comparable to that of influenza, tuberculosis and HIV/AIDS combined, according to a study published this week in The Lancet Infectious Diseases. The estimates are based on 2015 data from the European Antimicrobial Resistance Surveillance Network (EARS-Net) indicating that about 33000 people die each year as a direct consequence of an infection due to bacteria resistant to antibiotics. The study reveals that 75% of the burden of disease is due to healthcare-associated infections and that reducing this through adequate infection prevention and control measures, as well as antibiotic stewardship, could be an achievable goal in healthcare settings. Infections with bacteria resistant to last-line antibiotics such as carbapenems and colistin cause 39% of the burden. This is an increase from 2007 and is worrying because these antibiotics are the last treatment options available. When these are no longer effective, it is extremely difficult or, in many cases, impossible to treat infections. The study was developed by experts at ECDC and the Burden of AMR Collaborative Group. The results are used by the Organisation for Economic Co-operation and Development (OECD) to estimate the economic burden of antibiotic resistance. I. Executive summary EU Threats New! Local transmission of malaria ±Greece ± Opening date: 5 November 2018 Latest update: 9 November 2018 Since August 2018, Greek public health authorities have reported several locally acquired non-falciparum malaria cases, in the regions of Evros and Central Macedonia. -
Alcohol and Drug Abuse Subchapter 9
Chapter 8 – Alcohol and Drug Abuse Subchapter 9 Regulated Drug Rule 1.0 Authority This rule is established under the authority of 18 V.S.A. §§ 4201 and 4202 which authorizes the Vermont Board of Health to designate regulated drugs for the protection of public health and safety. 2.0 Purpose This rule designates drugs and other chemical substances that are illegal or judged to be potentially fatal or harmful for human consumption unless prescribed and dispensed by a professional licensed to prescribe or dispense them and used in accordance with the prescription. The rule restricts the possession of certain drugs above a specified quantity. The rule also establishes benchmark unlawful dosages for certain drugs to provide a baseline for use by prosecutors to seek enhanced penalties for possession of higher quantities of the drug in accordance with multipliers found at 18 V.S.A. § 4234. 3.0 Definitions 3.1 “Analog” means one of a group of chemical components similar in structure but different with respect to elemental composition. It can differ in one or more atoms, functional groups or substructures, which are replaced with other atoms, groups or substructures. 3.2 “Benchmark Unlawful Dosage” means the quantity of a drug commonly consumed over a twenty-four-hour period for any therapeutic purpose, as established by the manufacturer of the drug. Benchmark Unlawful dosage is not a medical or pharmacologic concept with any implication for medical practice. Instead, it is a legal concept established only for the purpose of calculating penalties for improper sale, possession, or dispensing of drugs pursuant to 18 V.S.A. -
Additional Materials
Truth Quality 11/15/2019 Controlled Substances Board: Law Service Enforcement Hearing - Crime Lab Presentation Mission: to promote excellence in analysis, training and service to the community and our Lead organization with integrity and uncompromising CS Unit Trends in 2019 quality. Character Science Integrity Division of Forensic Sciences Wisconsin State Crime Laboratories History Sandy Koresch Advancements Training Experts Vision: to search for the truth through science and to lead and shape the advancement of forensic science. Analysis Competence Wisconsin State Crime WSCLI Laboratories Milwaukee serves 8 Southeastern County Area Madison serves 24 Southern County Area Wausau serves 40 Northern County Area Wisconsin State Crime Laboratories 2 Controlled Substances Unit – Analyze evidence with suspected controlled substances submitted by law enforcement agencies – Most evidence is related to felony charges; some misdemeanors – Our focus is to identify controlled substances under Wisconsin Statute 961; other drug related substances may be indicated/identified – Types of evidence can range from powders, plant material, liquids, and tablets to drug paraphernalia and food items Wisconsin State Crime Laboratories 3 NFLIS DATA National Forensic Laboratory Information System https://www.nflis.deadiversion.usdoj.gov/NFLISHome.aspx Wisconsin State Crime Laboratories 4 Emerging Threat Report -DEA https://ndews.umd.edu/resources/dea-emerging-threat-reports Wisconsin State Crime Laboratories 5 NPS Discovery Center for Forensic Research and Education (CFRE) -Includes seized drug samples and biological samples https://www.npsdiscovery.org/ Wisconsin State Crime Laboratories 6 NMS/CFRE Webinar Wisconsin State Crime Laboratories 7 Crime Lab Data • Data affected by submission guidelines and law changes (hemp/marijuana) • Data includes items analyzed vs. -
NFLIS-Drug Selected Substance List
2017-2020 NFLIS-Drug Substance List (Sorted by Date) Date Added NFLIS Substance Name Synonyms Chemical Name Structure InChI Formula to NFLIS- Drug InChI=1S/C16H20BrN/ c17-14-1-3-15(4-2-14)18-16-12-6-10-5-11 Bromantane ladasten N-(4-bromophenyl)adamantan-2-amine C16H20BrN 12/7/20 (8-12)9-13(16)7-10/h1-4,10-13,16,18H, 5-9H2 InChI=1S/C21H29FN2O3/ c1-4-27-21(26)19(15(2)3)23-20(25)17-14- ethyl 2-(1-(5-fluoropentyl)-1H-indole-3-carboxamido)-3- 5F-EMB-PICA EMB-2201; 5-fluoro-EMB-PICA 24(13-9-5-8-12-22)18-11-7-6-10-16(17)18 C21H29FN2O3 11/12/20 methylbutanoate /h6-7,10-11,14-15,19H, 4-5,8-9,12-13H2,1-3H3,(H,23,25) InChI=1S/C20H27FN2O3/ c1-20(2,3)17(19(25)26-4)22-18(24)15-13- methyl 2-(1-(4-fluorobutyl)-1H-indole-3- 4F-MDMB-BUTICA 4-fluoro-MDMB-BUTICA; 4F-MDMB-BICA 23(12-8-7-11-21)16-10-6-5-9-14(15)16/ C20H27FN2O3 10/23/20 carboxamido)-3,3-dimethylbutanoate h5-6,9-10,13,17H,7-8,11-12H2,1-4H3,(H, 22,24) InChI=1S/C10H14BrNO2/ 4-methoxy-6-[(1E)-2-phenylethenyl]-5,6-dihydro-2H- 2Br-4,5-Dimethoxyphenethylamine 2-bromo-4,5-dimethoxyphenethylamine c1-13-9-5-7(3-4-12)8(11)6-10(9)14-2/ C10H14BrNO2 10/2/20 pyran-2-one h5-6H,3-4,12H2,1-2H3 InChI=1S/C16H22FNO/ 4-fluoro-3-methyl-alpha-PVP; 4F-3-methyl-alpha- c1-3-6-15(18-9-4-5-10-18)16(19)13-7-8-1 4F-3-Methyl-alpha-PVP 4-fluoro-3-methyl-alpha-pyrrolidinopentiophenone C16H22FNO 10/2/20 pyrrolidinovalerophenone 4(17)12(2)11-13/h7-8,11,15H, 3-6,9-10H2,1-2H3 InChI=1S/C21H26N4O3/ N,N-diethyl-2-[2-(4-methoxybenzyl)-5-nitro-1H- c1-4-23(5-2)12-13-24-20-11-8-17(25(26)2 Metonitazene C21H26N4O3 9/15/20 benzimidazol-1-yl]ethanamine