Annual Report

Home , Corneal transplantation

Annual Report

Fiscal Year Ending June 30, 2011

www.cornea.org

Table of Contents

Page 3 - 4 Message from Marianne Price, PhD Executive Director & OUR MISSION:

Francis W. Price, Jr., MD, Founder

and Chairman

TO B E A WORLD - Pages 5 - 6 Treasurer’s Report

Page 7 - 12 Donor Acknowledgement C L A S S R E S E A R C H

Page 13 - 14 Featured Research AND EDUCATIONAL

Page 15 - 16 Award Winning Research ORGANIZATION,

Page 17 - 18 Special Events

DEDICATED TO THE Your donations help restore sight. Page 19 - 22 Publications and Meetings

PRESERVATION About the Foundation About this Report AND RESTORATION As a 501(c)3 not for profit founded in 1988, the Cornea Research Foundation of America, The achievements featured within this report, along is an award winning, internationally recognized research and educational organization,

with the goals outlined for the future growth show- dedicated to the preservation and restoration of vision and known for conducting clinical case the dynamic research strategies underway at the O F VISION. studies to evaluate new drugs, lasers, devices and treatments. We measure our success Foundation. We work to develop and refine cutting-edge procedures and techniques to restore based on four pillars: Research, Innovation, Service to Humanity, and Education, summarized sight and faith for individuals around the world. in the acronym RISE. Our goal is to continually find new and better ways to give people back the use of their eyes so they can attend school, make a living, and support their family. We share our findings through frequent presentations, publications and medical education courses so that patients throughout the world can benefit from our findings. WWW.CORNEA.ORG

This last year represented the 22nd year of the Cornea Research Foundation of America, and it was a year of major achievements. Achievements ranged from A Message from the Executive Director discovering that a new ultra-thin corneal transplant has 15 to 20 times less risk of developing a rejection episode than earlier types of corneal transplants, to for the first time, describing the proteins in the anterior part of the eye which may be responsible for causing corneas to turn cloudy after glaucoma surgery. We also were able to accumulate more revenue through donations and study-related in- What an exciting year! Our work has attracted international recogni- come to fund our research activities. Since our foundation does not receive tion - we were invited to share our cornea transplant findings at major funding from the federal government, these contributions are essential for what eye meetings in Europe, Asia and South America. We were fortunate to we do.

have two gifted cornea specialists, from leading eye centers in Brazil and An often used saying is that with great gifts come great responsibility, and we Singapore, join us for one-year research fellowships. Dr. Guerra and Dr. take our gifts very seriously. The Foundation is embarking on an ambitious re- Anshu were incredibly productive and their work on improved cornea search path that has the potential to dramatically change the way we approach vision correction, transplant transplant techniques resulted in 12 publications in leading eye journals. treatments, and management of those with complicated glaucoma problems. In addition, we were honored to receive the prestigious Santa Caterina Because of our ongoing corneal transplant data base, the largest one in the Western Hemisphere, we can d’Oro award for excellence in medical research, at a lovely ceremony compare rejection rates between standard full thickness corneal transplants, DSEK transplants, and the new held annually in the historic town of Siena, Italy. ultra-thin DMEK grafts. We recently found that the chance of having a rejection episode is15 times less for DMEK than DSEK, and 20 less in comparison to a full thickness transplant. Topical corticosteroids, the anti- We envision a future where corneal problems are detected and treated early, before leading to seri- rejection drops we use after corneal transplants cause about 1/3 of patients to develop glaucoma in the first ous vision loss. We are making steady progress toward this goal by identifying the underlying genetic year after receiving a transplant. Since DMEK appears to have a significantly reduced rate of rejection, the causes of Fuchs dystrophy. This work should ultimately lead to early detection and innovative treat- Foundation is sponsoring a multi-center, international study to evaluate two different corticosteroid dosing ments. In addition, we are having good results with an investigational corneal strengthening treat- regimens to see if we can reduce the rate of developing glaucoma without increasing the rejection rate. No ment that can help preserve the vision of teenagers and young adults who have a condition known one has ever done a prospective study evaluating different topical corticosteroid dosing regimens for corneal as keratoconus. transplants even though it is the most common tissue transplant in the U.S. for over 60 years. And like all medications used with corneal transplants, it is an ―off label‖ use of the drops – so the FDA told us we had to Collaborating with other centers around the country, we detected a surprisingly high incidence of file for investigational drug exemption (IDE) study with them – which we have. antibiotic-resistant bacteria on the surface of the eye and eyelids of patients scheduled for cataract The Foundation is sponsoring a prospective, 3-year study with both national and international study sites eval- surgery, clearly demonstrating the need for new and improved antibiotics. To help address this uating patient satisfaction and visual difficulties with different vision correction methods. Other than glasses, need, we are among a select group of centers pioneering the use of an innovative light treatment to contact lenses and Lasik are the two most common ways to correct vision. No one has ever taken on a study kill organisms that cause eye infections. Some of the most serious eye infections occur in young to evaluate how satisfied patients are with these means of visual correction and what their visual difficulties people who wear contact lenses for extended periods of time, and we are finding this treatment to might be. Industry is reticent to do this I suspect due to liability and regulatory concerns. The government, be very helpful for these young folks. well, they seem preoccupied with other things right now. From a public health standpoint and planning for future correction of vision, this study is very important and should lead to identification of areas of improvement We are proud that Working Vision, the fledgling organization we helped nurture the past several for both contact lenses and Lasik. We hope to enroll between 2 and 5 thousand patients. Funding will deter- years, has recently taken flight and achieved independent non-profit status. Working Vision is the mine the number we can enroll. brainchild of Grant Moore, one of our former summer interns who later spent a summer working at a large eye clinic in Kathmandu, Nepal. While there, he was amazed at the number of patients Finally, our third major area will be looking at fluid taken from the front part of the eye to help determine why some patients, like those with glaucoma filters, have damage to the endothelial cells on the inside of the cor- with serious eye injuries that could have been prevented with proper eyewear. So he initiated a pro- nea and to see what is happening in eyes with rejection episodes. Our hope is to develop focused, more effec- gram to collect new and gently used safety eyewear in the USA for distribution in Nepal. Working tive treatments for both of these problems Vision continues to expand in scope and now provides eye safety programs and vision screenings, in addition to distributing safety eyewear. It’s been an honor for us to support these efforts. Each of these three studies are major undertakings, and each has the potential to make landmark changes in the way we treat diseases of the eye. Your gifts and support make all of this possible. Thank you! Helping people regain vision and resume daily activities is an immensely rewarding endeavor. We appreciate the generous support of our donors and the dedication of our staff that makes this Francis W. Price, Jr., MD possible. Sincerely, Founder and Chairman

Marianne O. Price, Ph.D. Executive Director A Message from the Chairman

Treasurer’s Report by Walter C. Gross, Jr.

The Cornea Research Founda- tion of America had a great year. Total revenue for the fiscal year ended June 30, 2011 was $742,510. In comparison to 2010, we saw an increase due to substantial growth in clinical study earned income. Our In-Kind Contributions were also much higher than in years’ past, thanks to services generously donated by many doctors.

We are careful with our expenses, and for that reason 89% of our operating budget directly funds research and edu- Revenue Expenses cation programs. 1% 6% Guidestar and the Better Busi- 5% 5% 27% Contributions ness Bureau’s Wise Giving Research and Education Alliance have certified that the 24% Service Related Income Foundation meets their Charity Development In-Kind Contributions Accountability Standards. Special Events Administrative

Interest and Other Walter C. Gross, Jr. Treasurer 43% 89% John C. and Bette B. Miller Marilou L. Dickey Anonymous Charitable Foundation Jack and Jane Donadee Wayne and Linda Adams The Semler Family Foundation We thank our generous supporters. Essilor of America, Inc. Rider Insurance Agency Gem-Young Insurance & Financial Fairfield Engineered Drive Solutions Akers Tire Company, Inc. Service, Inc. Michael and Jeanette Garvey Mohammed Al Marar Goelzer Investment Management Chloe Alyce Hughes Applied Engineering Services Inc. Jerry Grage Lehmann Eye Center Audrey Ingram Joseph and Barbara Barker Founder Homewood Suites—Keystone Eye Center of North Colorado Joe Kack Canfield Lions Club, Inc. Gifts $25,000 or greater Indiana Lions Eye and Tissue Buckley Chang Eye Institute Richard and Barbara Justice Ryan Cole Joseph M. & Barbara Cohen Foundation, Inc. Transplant Bank Gordon & Weiss Vision Institute Harold Laut Melvin and Frances Davis Joseph Benitez Jr., MD Limberg LASIK Institute M&I Bank Bud DeCleene, OD “Thank you so much Lenore Anderson Endowment Humanitarians Milauskas Eye Institute Marco Frank and Beverly Deramo for all your time, effort Kathryn Lumb Jewish Communal Fund Carl Zeiss Meditec, Inc. John Devine Gifts from $10,000 to $24,999 and professionalism Shirley Mitchell LaserVue Oasis Medical, Inc. George and Alpha Dinkel Anonymous William and Margaret O’Conner Frederic and Frances Nathan during all my Craig Olson EAH-JJK Properties, LLC Gaughan Family Foundation Ron Roach Price Vision Group LensTech Optical, Inc. Philip and Patricia Gibson The O’Conner-Campion Family questions, phone calls Synergeyes Dr. Francis W. Price, Sr. Jeffrey and Laurie Potrzebowski Robert and Cynthia Grimm Charitable Fund and visits. You were The UPS Foundation, Inc. Schneider Vision Marijke Raju Stephen J. Hackman Bill Grube Norwood A. Whitfield San Antonio Eye Specialists awesome! Cheryl Sokoll Jeffrey King Tom D. Kievit Joseph and Kay Wiley Kenneth Swedo Joseph and Geraldine La Motta It would have been STAAR Surgical Company Richard King Bluestein Custom Vision Schwarz Partners, LP W.H. Voll impossible to decide on Partners Lewis Liggett Bucci Vision Stanley and Barbara Schwartz Holly and Dennis Lewton Wilton J. Johnson crosslinking without Gifts from $500 to $999 Shirley and Erwin Zimmerman Patrons Doug and Carol Moore your knowledge and Donald and Janet Baumgartner Friends Michael Mullen Gifts from $5,000 to $9,999 Fellows information you shared Peter Burchanowski Marsha Murman Roland and Pat Chastain Gifts from $250 to $499 Gregory and Robin Pemberton Fredric and Myrna Gershon Gifts from $1,000 to $2,499 with me. You have a Walter and Janet Gross Joseph and Deborah DeRanieri Sherry and Douglass Abney Adam Reising, OD Kenneth Anderson great team!” Michael Dickerson Accenture Ronald G. Salatich Huntington National Bank

Calumet Lubricant - Donna L. Benefactors Marvin Cave Gifts from $2,500 to $4,999 David and Laurie Hill Chapman Carter Eye Center Sidney and Lois Eskenazi Without you, we could not do what we do. Katzen Eyecare and Laser Center Eye Physicians, Inc. Vincent Wagner Rick Bruno Friends (continued) Garry and Diane Warner Phillip & Shirley Buchanan We thank our generous supporters. Gifts from $100 to $249 Roy Michael Whetstine Theodora Callas

Carolyn Mock Marcus and Marylou Winslow Claire Cartmell James and Doris Morton Thelma J. Woodring Susan Cassudakis Christine and Edward Muransky Jack and Florence Wright Harold Chambers Friends (continued) Thomas Boone Steven and Leslie Gordon Frederic and Jane Nott Paul Wussow Timothy and Susan Cianciola Gifts from $250 to $499 Fred and Ellen Boso Wayne and Marilyn Greve John and Toula Oberlies Connie Zambelli Linda Cline Noha Khouri James and Pearlie Corbitt Scheid Realty Fred and Sandra Brown Maurice Hahn Elizabeth Pasut Joumana Seifeddine Vera Cox Jay and Mary Sue Schwartz Michael Bruno James and Jean Harrington Edwena Payne Joseph and Chery Crum Harold A. Sherline Carmen Bullock, OD Robert and Amy Hendricks Albert and Audrey Pekelney Billy and Natalie Cupler Bob Smelser Timothy Buren Diane Hido John Peters, MD Friends Anthony and Amy Daprile William Stifle James and Charlotte Butler Robert and Elizabeth Hiller Angela and Francis Pierce Gifts up to $99 James Daprile Janet and Gary Taylor Robert and Mary Ann Campbell David Huse, DVM Larry and Jessie Rash Kimberly Davis Temp Control Service Laverne and Ruth Ann Clingenpeel Linda and Richard Hutchinson Judith A. Ratliff Carmela Abraham Chris and Cheryl DeHoff Jeffrey Thacker Bopp-Busch Manufacturing Company Jack Frisch & Associates Reddington Christian Church John Arditi Susan Domer Trendy Trousseau LLC Mary Conners Jostad Enterprises Roger Reichmuth Peter and Sharon Asimakopoulos Marie Cormican Kathy Kelley, OD Jack and Joetta Riggin Neal and Suha Atway Linda Eyer Patricia Cowan Betty and Robert King Salem Women’s Care, Inc. Mr. and Mrs. Jack J. Baker Samuel Faccioben Friends Baker and Daniels Fred and Vicky Kline Harry W. Scheid Lucina Barnum-Steggerda James and Martha Fairfield Gifts from $100 to $249 Joseph Daprile Seneca One Realty, LLC Larry Sebeckis John and Mary Battaglia Gerald Fallon Dr. Keely Allen Victor Daprile Dr. Alfons Landwehr Deborah Shepherd Howard and Carla Beeson Drew Fasseas Mary Alice Andrews David and Linda Daringer Jack and Joan Lane James and Mary Shepherd Lester Beisner John Fazzone Anna Mae Lane Ted and Janet DeGarmo Judith Lasky, PhD Helaine Simon Virginia Belcher Timothy and Ruth Franklin Donald and Michele Argay Myron and Nancy Dickerson Eli (Ted) Lilly II Howard Steiner Betty Belschwender Margaret Freeman Leland and Carol Ballard Steven Doi, OD Guy and Arleen Lucci John and Eileen Takach Stephen and Cynthia Bennett Tonya and Brian Frost Richard and Karen Banning Harry Donovan James and Theresa Maciver Patricia Thomas Julie Benson Royce Garrett Sadie Barger Robin Felkins Gayle Mason Sherill and Delbert Thornburg Mark and Michelle Billy Cecelia Gastelum Jeffrey Barnaby Sheila Fiala Robert and Alana Mauzy David and Joyce Thurman Daniel and Rosemary Blilicki Karen Giorgetti Duane and Nancy Bassett Timothy M. Fischer Alan and Margaret McCall George and Angela Tzakis Paul and Jayne Boucherle Sydelle Golub Beckwith, Daprile & Co. JP Morgan Chase Foundation Rue and Carolyn McFarland Michael and Rebecca Unfried William W. and P.A. Bromer William P. Goodman, III Larry and Sue Bennett John Frank Ralph Michalec Colleen Vella Brent Brown Brian and Melinda Governor Jeffrey Boller William Golfsmith Wendy Mickler Earl and Martha Vogt Susan Taracuk Brown Dorothy Grainger

Friends (continued) Honor and Memorial Contributions Gifts up to $99 We thank our generous supporters. Lucinda Barnum-Steggerda in honor of Robert Barnum Steven and Sally Warden Seneca One Realty, LLC in honor of Jane Kelsch Lisa and Andrew Weiss Mary Lynn McIntyre in memory of Charlie Anne Newton Phillip and Jacquelyn Weybrant Friends (continued) Paul Whitehead Michael Kovatch Stepheny and James Pisciuneri Mark and Georgia Wilson Gifts up to $99 Study Related Income Matthrew Kusy William and Debra Pisciuneri Barbara Woerner Thomas Green Alcon Laboratories ISTA Pharmaceuticals Joseph and Mary Jo Lenefonte Richard Preske James Wood Donna Griesmer Allergan Jaeb Center for Health Research, Inc Amanda Lopez James and Julie Rafoth John Yerian Joan Hackler Avedro Patient Education Concepts/CRM Anne-Marie and Mark Luchansky Lee Rasamny Jaime and John Yohman David and Traci Hardy Case Western Reserve University Trial Runners, LLC Steven and Palan Lussier Glendolyn Rhymer Anthony and Concetta Young Jennifer and Paul Harris Cook Pharmaceuticals University of Illinois– Chicago Neva Maloy Bessie and Melissa Rice Lynn Scarnati Zvara Max and Eldred Hauk Inc Research, Inc. Dawn Marzano Mark and Nancy Sabol Michael Thomson Michael and Marsha Hile George and Beverly Mattox Michael Schaub Annabelle Willett Carol Hinkle Donnalou and Patrick McVay Kurt Schwant Dale and Jo Ann Hoepf Virginia L. Merillat Daniel Schwartz Sarah Hoover Jemilla Kidanu Michael Connie Shepherd Marceda Hosted Helen Miller Charles and Shirley Shoppell Robert Hotchkiss Norman T. Mills Rita Sibert Pamela Hudson Annabella and Dominador Miranda Robert D. Sipress Dorothy Ann Hummel Toby and Janet Mirto Catherine Slovan John W. Hussey Richard and Cherie Mize Marlyse Spicer You help make better Samuel Jacobs Kamel Muakkassa Erwin F. Springer David and Michelle Jakovina Joyce Nevil Stanich SCP vision possible. Greg Jansen Elaine and Donald Newman Pamela Steinhauser Jaime Jarvis David and Candice Niederhaus Phil Stuart, OD Doris M. Johmann Richard and Nancy Novotny Marilyn Sullivan Myron and Rose Jane Kaiser Vilma Ortiz Doris Szijj Megan and Roland Kaleel Asha and Sushil Pandhi Joseph and Debbie Thomas Carol Kalp Martin and Teresa Papai Judith Thomas Julie Kamenitsa Richard and Phyliss Paul Tunno Insurance Agendy Roger and Ellen Kinsey Patricia A. Peters Nancy and Michael Vince

DMEK—The Latest Advancement Preventing Cornea Transplant Rejection in Cornea Transplants

One of the biggest risks transplant recipients face is that immunologic graft rejection will cause the new Exciting News donor cornea to fail. Corticosteroid eye drops are Decreased risk of rejection from 12 percent to less than 1 percent!

typically used for months or even years to prevent Corneas are about the thickness of a credit card and are comprised of three distinct layers. Although cornea transplant rejection. Unfortunately, these eye corneal problems are usually localized to just one or two layers, the traditional approach was to replace drops have some serious side effects. Surprisingly, no them all. In Figure 1 below, the arrow is pointing to a single line—this is the thickness of a cornea transplant using the DMEK technique. In Figure 2, the overall length of the red arrow represents the prospective randomized studies have been done to thickness of a full thickness transplant.

determine the best corticosteroid-dosing regimen, so Dr. Price helped pioneer cornea transplant techniques that replace only the diseased portion of the solid evidence on what is the best dosing for transplant cornea, leaving healthy layers intact. Only the ultra-thin cell layer lining the inner surface of the cornea is diseased in about half the patients who need a transplant. According to Dr. Price, ―Replacement of patients is lacking. We have found that the new, the inner cell layer with a single cell layer from a donor cornea (a technique known as DMEK) provides minimally invasive transplant procedure called DMEK much better and faster visual recovery than earlier methods.‖

has a very low risk of rejection. So we have initiated a The reason cornea transplants fail is because the recipient’s body can recognize the donor tissue as for- large study to see if we can reduce the topical eign and mount an attack against it. Our research has found that single layer DMEK grafts are 15- to 20 -times less likely to be rejected than earlier techniques that include two or more layers of the cornea.

corticosteroid strength, and avoid some of the steroid side effects, while maintaining a low risk of rejection According to Dr. Price, ―99% of our DMEK recipients remain rejection-free at two years and beyond. Having a transplant technique that can better elude rejection is a huge breakthrough for cornea trans- after DMEK. We will enroll 440 patients in the study plant recipients.‖ and follow each patient for one year. This landmark

FIGURE 1 FIGURE 2 study will provide valuable new information to help DMEK Full Thickness Transplant

cornea transplant recipients maintain newly restored Key Research Areas Research Key vision.

Key Research Areas Improving Cornea Transplant Survival with a previous corneal transplant as serve controls. reasons. Fluid samples collected from cells from the back surface of thecornea for unknown rejection episode, or they experienced a sudden loss of glaucoma surgery, they had an acute immunologic graft increased risk of graft failure either because they had prior samples from cornea transplant recipients who are at discoveries by collecting and analyzing aqueous humor surgery. We are following up onthese promising changes that occur in fluidthe inside eyethe after glaucoma cornea transplant failure, and we identified some intriguing areglaucoma surgery high risk at particularly for early earlierIn studies, we found that patients who have had We’re evaluating up subjects. to360 needed to help maximize cornea transplant survival. to fail.starts This study willprovide key information changes that occur in this fluid a corneawhen transplant ofhealth cornea.the In thisstudy we will identify the cornea and provides key nutrients that help maintain the aqueousthe humor. fluidThe bathes the back surface of the removing and analyzing fluid from inside the eye, called to extend transplant survival. We are doing this by sometimes fail early and to develop innovative treatments much sooner. We are working to figure out why transplants clear for years,at least 10 but insome patients they fail front surface of eye. the Cornea transplants usually remain transplant to replace the cornea, the clear window on the yearEach approximately 42,000 Americans need a

Key Research Areas

uncomplicated eyes

please visit www.cornea.org and click on patients in the study. Study sites throughout Unitedthe States are currently enrolling participants satisfaction, visual complaints and safety continue to wear lenses.contact We determine will if visual patients Our goal of the study is to enroll between 2 and5 thousand anniversaries of study the date of entry. coordinate future patient surveys one,at the two and three using a HIPAA compliant web that will automatically portal Patient consents and surveys are conducted over internet the simultaneously. correction for nearsightedness, astigmatism, and farsightedness prospective study tofollow thesetwo popular methods of vision issues as they relate to LASIK and contact lenses. This is the first comparing visual results, patient satisfaction and quality of life FoundationThe is conducting a national clinical survey study Research and Current then Studies. Vision Correction MethodStudy o opeelsigo our For acomplete listing of -

both thoseundergoing LASIK, and patients who will –

are similar or different between the two groups.

current studies, LASIK/Contact Lenses

–

as reported by

—

year

Foundation Staff Award Winning Research Board of Directors

Marianne O. Price, Ph.D. Drs. Price receive Santa Catarina Award in Sienna, Italy Francis W. Price, Jr., MD Executive Director Founder and Chairman

Francis W. Price, Jr. , MD and wife Jessica Dingledy F. W. (Bill) Grube Marianne Price, PhD were presented with Development Director Vice President the ―Santa Caterina Oro Città di Siena‖

International Prize on February 27, 2011 Clorissa Quillin Trischa L. Zorn-Hudson in Siena, Italy. Drs. Price traveled to Siena Research Coordinator Secretary and were honored at the ceremony re-

ceiving the Santa Caterina gilded statue at Walter C. Gross., Jr. Kelly Fairchild the Teatro dei Rozzi in Siena. Treasurer Research Coordinator Francis W. Price Jr., MD of Price Vision

Group is the founder and president of the Cornea Research Foundation of America, Jim Butler Maraya Baumanis and his wife, Marianne is the Foundation’s executive director. Together they were cho- Research Intern sen as recipients of the Santa Caterina prize as their research has led to significant im- Frank Clifford provements in cornea transplant surgery and treatment of eye diseases around the Michael W. Dickerson Lauren Gunderson world. Phil Gibson Research Intern Each year, ten recipients from different areas of expertise all over the world are select- ed to receive this prestigious award. The Prices commented, ―We feel blessed to have Robert Grimm found better ways to give people back the use of their eyes and to have had the oppor- David C. Huse

tunity to share improved techniques with eye care professionals nationally and interna- Toula Oberlies tionally.‖ For more information, visit http://www.cornea.org. Jerry D. Semler

Events The Foundation would like to thank all of Golf Committee Focus on Education Optometrist Seminar those who served on our Cornea Classic Golf Committee for organiz- Harry W. Scheid Chairman ing a successful golf outing on June 2, 2011 at Wood Wind Golf Club in West- November 2010 field, Indiana. The event raised nearly Vern Rensing $28,000 to fund our mission to provide Vice Chairman research and education to preserve and restore vision. Thanks to all who donated, Pat Chastain sponsored and participated in the event. Mike Dickerson The outing will be held on June 21, Phil Gibson 2012 next year. If you would like to Walter C. Gross, Jr. receive the registration form in February, Mark Horton give us a call at 317-814-2993. Joe Kack Francis W. Price, Jr.,

Each year the Foundation sponsors an all-day seminar for optometrists that features programming on the latest treatments and surgeries available for the anterior segment of the eye and cornea. Attendees earn approved continuing education credits while learning about the newest ophthalmic June 2011 medical devices, pharmaceuticals, and practice management techniques. Cornea Classic Golf Outing a Success

Guerra FP, Price MO, Price FW. Is central pachymetry asymmetry between eyes an independent risk factor for ectasia after LASIK? J Cataract Refract Surg 2010;11:2016-7. PUBLICATIONS Letko E, Price DA, Lindoso EM, Price MO, Price FW. Secondary graft failure and repeat endothelial keratoplasty after Descemet's stripping automated Between July 1, 2010 and June 30, 2011 endothelial keratoplasty. Ophthalmol 2011;118:310-4.

Hayes DD, Shih CY, Shamie N, Terry MA, Price FW Jr, Price MO, Ritterband DC, Hannush SB, Gorovoy MS, Weisenthal RW, Ritch R, Liebmann JM, Udell IJ. Spontaneous reattach- Click on the blue hyperlinks to read each publication. ment of Descemet stripping automated endothelial keratoplasty lenticles: Am J Ophthalmol 2010;150:790-7. a case series of 12 patients. Price FW, Price MO, Arundhati A. Descemet stripping automated endothelial keratoplasty under failed penetrating keratoplasty: how to avoid complications. Am Price MO, Price FW. Deep anterior lamellar keratoplasty: coming of age. Br J Oph- J Ophthalmol 2011;151:187-8. thalmol 2010;94:1275-6

Olson R, Donnenfeld D, Bucci FA, Price FW, et al. Methicillin resistance of Staphylococ- Price MO, Price FW. Descemet membrane endothelial keratoplasty. Int Ophthal- cus species among health care and nonhealth care workers undergoing cata- mol Clin 2010;50:137-47. ract surgery. Clin Ophthalmol 2010;4:1505-1514. Price MO, Price DA, Fairchild KM, Price FW. Rate and risk factors for cataract for- Da Reitz Pereira C, Guerra FP, Price FW Jr, Price MO. Descemet's membrane automat- mation and extraction after Descemet stripping endothelial keratoplasty. Br J Ophthalmol 2010;94:1468-71 ed endothelial keratoplasty (DMAEK): visual outcomes and visual quality. Br J Ophthalmol 2011;95:951-4. Kwon RO, Price MO, Price FW, Ambrosio R, Belin MW. Pentacam characterization of corneas with Fuchs dystrophy treated with Descemet membrane endothelial keratoplasty. J Richardson MR, Segu ZM, Price MO, Lai X, Witzmann FA, Mechref Y, Yoder MC, Price FW. Al- Refract Surg 2010;26:972-9. terations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy. Molecular Vision 2010; 16:2376-2383 http://www.molvis.org/molvis/ v16/a255

McCauley MB, Price MO, Fairchild KM, Price DA, Price FW. Prospective study of visual For a complete listing of our publications, outcomes and endothelial survival with Descemet membrane automated endothelial keratoplasty. Cornea 2011;30:315-9. please visit www.cornea.org and click on

Price MO, Fairchild KM, Price DA, Price FW. Descemet's stripping endothelial kerato- Research and then Publications. plasty five-year graft survival and endothelial cell loss. Ophthalmology 2011; 118:725-9.

International Innovation Technology Meeting, MEETING PRESENTATIONS Mendoza Argentina, December 2010 Price FW, Price MO. New indications for corneal collagen cross linking. Price FW, Price MO. Endothelial keratoplasty under failed penetrating keratoplasty: how to minimize complications. Price FW, Price MO. DMEK and DMAEK: patient selection and how to optimize visual results with Between July 1, 2010 and June 30, 2011 endothelial keratoplasty. (Keynote lecture). Price MO, Price FW. DSAEK long-term graft survival and comparison with PKP. (Keynote lecture).

Price MO, Price FW. Impact of glaucoma on DSAEK: is it different from PKP? Price MO, Price FW. What has been learned about graft rejection? Eye Bank Association of American Annual Meeting, Tucson, AZ, June 2011. Asian Cornea Society Bi-annual Meeting, Price MO, Gorovoy M, Benetz BA, Price FW, Washington K, Debanne S, Menegay H, Lass J. DSAEK outcomes at three Kyoto, Japan, December 2010. years compared with penetrating keratoplasty from the Cornea Donor Study. Eye Bank Association of America Price FW, Price MO. Endothelial Keratoplasty Overview: where are we now and where are we going? Scientific Session, June 25, 2011, Tucson, AZ. (Keynote lecture). Soper M, Price MO. Eye bank preparation of DMAEK tissue (DMEK with stromal ring). Price FW, Price MO. Long-term Outcomes of DSEK/DSAEK. (Keynote lecture). Price FW, Price MO. Surgical tips for DMEK and DMAEK. West Virginia Academy of Eye Physicians & Surgeons annual meeting, Price MO, Price FW. What have we learned about IOP control and outcomes in DSEK/DSAEK eyes with and without glaucoma? White Sulfur Springs, WV. June 2011 Price MO, Price FW. Outcomes of DMEK, DMAEK, and eye bank prepared DMAEK grafts. Price FW, Price MO. The current state of the art in corneal crosslinking. Price FW, Price MO. Anterior lamellar keratoplasty.. Price FW, Price MO. Evolving surgical techniques in endothelial keratoplasty. Cornea Society/EBAA Fall Educational Symposium, Price MO, Price FW. Glaucoma/IOP control, topical corticosteroid use, and immunologic graft rejection with endothe- Chicago, IL, October 2010. lial keratoplasty. Price MO, Soper M, Price FW. Use of eye bank-prepared donor tissue for Descemet membrane Price MO, Price FW. Management of cataracts in patients with Fuchs’ dystrophy. automated endothelial keratoplasty (DMAEK). Price MO, Price FW. Long term endothelial keratoplasty survival and risk factors for graft failure. Price FW, Price MO, Guerra F, Schrier A. Prospective randomized trial of cross-linking for infectious keratitis. Association for Research in Vision and Ophthalmology annual meeting, Guerra F, Price MO, Price FW. Fellow eyes comparison of DSAEK and DMEK.

Ft. Lauderdale, FL. May 2011 Price MO, Anshu A., Price FW. Outcomes of endothelial keratoplasty under failed penetrating American Academy of Ophthalmology annual meeting, keratoplasty. Chicago, IL, October 2010. Price MO, Price FW. Do Larger Descemet Stripping Endothelial Keratoplasty Grafts have Better American Society of Cataract and Refractive Surgery annual meeting, Long-term Endothelial Cell Density? (Best poster award).

San Diego CA, March 2011 Guerra F, Price MO, Price FW. Fellow eye comparison of DSAEK and DMEK. (Best Cornea poster award). European Society of Cataract and Refractive Surgery Arundhati, A, Price MO, Price, FW. Descemet-stripping endothelial keratoplasty survival outcomes in eyes with pre- annual meeting, existing glaucoma. Sept 5, 2010, Paris, France. Guerra F, Ambrosio, R, Price MO, Price FW. Preliminary results of enhanced ectasia screening of refractive surgery Price FW. Outcomes with Femtosecond laser assisted corneal transplants over a 4.5 year period. patients based on corneal tomography. Price MO, Price FW. Five year graft survival of Descemet stripping endothelial keratoplasty. Arundhati A, Price MO, Price FW. Outcomes of endothelial keratoplasty under penetrating keratoplasty. Price FW, Price MO. Prospective multi-center analysis of 1-year outcomes with DMEK. Planchard B, Price MO, Price FW. Retained viscosurgical device as cause of interface haze after Descemet-stripping en- Price FW. Cross linking for the treatment of corneal infections. dothelial keratoplasty. Price FW, Price MO. DSAEK: five-year results. Price FW, Price MO. Setting new benchmark for LASIK.

Societa Italiana Trapianto di Cornea annual meeting, Aegean Cornea Congress, Bologna, Italy, February 2011 Crete, Greece, July 2010. Price FW. Current Status of Posterior Corneal Transplantation. Price FW, Price MO. Ten years experience with endothelial keratoplasty. (Keynote lecture). Price MO, Price FW. Long term visual outcomes and graft survival after DSAEK. (Keynote lecture). Thank you for taking the time to review our 2011 Annual Report.

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