Health Research Board Annual Report 2019 €38.4M to Support 164 Awards Across 18 Host Institutions and Research-Performing Organisations

t Ireland D02 H638 Dublin 2 67-72 Lower MountStreet Grattan House Health Research Board Éire D02 H638 Baile ÁthaCliath 2 67-72 SráidanMhótaÍochtarach Teach Grattan An BordTaighde Sláinte w e

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5000 Annual Report 2019 Action. Evidence. Research. Published by:

Health Research Board, Dublin

Chair and Chief Executive’s report 4 Snapshot of HRB activities during 2019 7 Key deliverables in line with HRB strategy 2016–2020 13 Appendix A – HRB publications in 2019 37 Appendix B – HRB awards made in 2019 – to Principal Investigators 39 Appendix C – HRB co-funded awards 58

Research. Evidence. Action. 1 Outcomes and Impact in 2019

128,000 8,142 live records patients contributing to on LINK clinical studies at the three HRB Clinical Research Facilities (HRB-CRFs), including 916 patients participating in active active1,375 users on LINK clinical trials online data system

179 4,643 requests for data cancer patients contributing to 166 Cancer Trials Ireland from the HRB NHIS received and studies; 1,775 of these cancer responded to patients are participating in 135 active clinical trials €38.4m awarded (including €6.5m co-funding) 164 5 awards across 12 evidence reviews host institutions and produced for the research-performing Department of Health organisations

peer-reviewed journal articles 11 published using HRB National Health Information Systems (NHIS) data

249 clinical studies underway at the three HRB Clinical Research Facilities (CRFs); 116 of these clinical studies are €16.9m active trials leveraged from Horizon 2020 for 19 health-related projects and a further €0.5m leveraged from the Public Health Programme 16 HRB reports published 172 Research.research Evidence. jobs Action. 3 supported Chair and Chief Executive’s Report

Prof Jane Grimson Dr Darrin Morrissey Chairperson Chief Executive

The HRB continued to make strong Health research delivery and impact progress during 2019 to deliver the Key initiatives delivered during 2019 included: HRB Strategic Plan (2016–2020). The • Funding a selection of new and existing introduction of new award schemes and awards worth more than €38 million, which career paths for health researchers is are aligned to our strategic priorities; some having a positive impact for researchers, examples include: supporting development of health research > Collaborative Doctoral Awards to support infrastructure and helping to build doctoral training programmes for future capacity in order to involve citizens across health researchers in a variety of specialties the health research lifecycle. The HRB’s > Emerging Investigator Awards to boost reputation for the provision of quality data the development of new and talented and evidence continues to grow, and this is researchers and guide them to research reflected in national policies and requests independence from other organisations to re-use the data > Secondary Data Analysis Projects awards we collect. to develop research projects that answer policy and/or practice-relevant The HRB’s influence, and the impact of the questions using secondary data work the organisation is doing, is evident both > Proof of Concept of a data environment nationally and across Europe. In Ireland, we for health and related research using the continue to lead the way in key areas such data, access, storage, sharing and linkage as open research, and public and patient (DASSL) model. involvement in research. In Europe, we hold leading positions on advisory groups in areas • Delivering five evidence reviews and such as drugs, research integrity, biobanking, completing five evidence briefs for the and personalised medicine, which gives an Department of Health, encompassing areas important voice to Irish researchers in a such as vaccine injury redress programmes European context. and investigating the impact of introducing a regionalised healthcare system. Through this report, we illustrate some of the • Achieving PubMed indexing for HRB Open impacts we have made and some of the new Research, Ireland’s first open access directions we have taken during 2019. This publishing platform. was achieved through the commitment and dedication of staff and the skilled oversight • Supporting more than twenty conferences of the HRB Board. We extend our thanks and and events through our sponsorship call. appreciation to both our staff and the Board for • Awarding the first HRB Impact Award the significant progress made during the year. to Professor Mary McCarron, TCD, to

4 Health Research Board Annual Report 2019 €38.4m to support 164 awards across 18 host institutions and research-performing organisations

acknowledge her work and research that • Enabled more than 4,500 cancer patients is transforming the lives of people with to enrol in 166 Cancer Trials Ireland clinical intellectual disability as they age. trials and studies. • Publishing three evaluation reports on More detail on these and other examples and case clinical research infrastructure, research studies which demonstrate what was achieved leaders, and outputs and outcomes from during the year are included throughout this report. HRB awards completed in 2016 and 2017. • Establishing the Secretariat support office Health research collaboration for the national Health Research Consent Working together with other funders and Declaration Committee. research-delivery bodies, we have had some • Developing a new financial management system significant achievements during the year. This merging three separate financial systems into has involved: one single application in order to consolidate • Using data from our National Health financial controls and provide enhanced real- Information Systems (NHIS) to help the time financial reporting and metrics. Road Safety Authority (RSA), National Office of Suicide Prevention, and • Achieving gender balance, both in HRB peer the National Directorate for Fire and review panels and in funding awards. Emergency Management to understand the • Hosting an interactive conference for HRB circumstances of deaths. grant holders, centred around the concept • Researching co-funding initiatives both of ‘design thinking’, in order to encourage on the island of Ireland – with Science lateral thinking and approaches to health Foundation Ireland, the Irish Research research ideas. Council, the Health and Social Care Research Through its funding mechanisms, the HRB: and Development Division of the Public • Invested €38.4 million in supporting 164 Health Agency in Northern Ireland and health research awards across 18 host institutions research charities – and internationally – with and research-performing organisations. the Wellcome Trust Fulbright, the National Institutes of Health in the United States (US), • Supported 172 research jobs. and EU joint programming initiatives. • Helped Irish researchers leverage around €17 • Hosting a meeting of the international Funders million from Horizon 2020. Forum on Ensuring Value in Research. • Supported the recruitment of more than • Co-hosting a workshop on dementia research 8,000 patients in 249 clinical trials and with the HSE National Dementia Office. studies underway at HRB Clinical Research Facilities (CRFs). • Providing data on the drug treatment situation in Ireland, in order to inform

Research. Evidence. Action. 5 European monitoring and trends, in This started with a comprehensive consultation collaboration with the European Monitoring process which involved meetings and workshops Centre on Drugs and Drug Addiction with multiple stakeholder groups as well as an online (EMCDDA). survey that generated more than 220 responses. • Working with the Department of Health to The outcomes from the consultation process deliver the second National Drugs Forum, contributed to an international expert which took place at the Aviva Stadium, advisory panel who convened in October 2019. Dublin, in November. Their role was to assess the HRB’s strategic performance to date, draw together key New directions emerging themes from the broad stakeholder The HRB is actively working with the engagement process, and to offer their Department of Health to deliver upon and international perspective on future directions implement new legislation and regulation in for health research in Ireland. relation to health research. To this end, two new offices will have been established in the We would like to acknowledge the valuable HRB over the period 2019/2020. insights and recommendations we received throughout the consultation process Using The HRB Secretariat for the Health Research input from the various stakeholder groups Consent Declaration Committee (HRCDC) and the international panel, the HRB Board became fully operational in January 2019. It is currently working on developing new has a strategic role in supporting the Health strategic priorities and key actions for the new Research Regulations 2018. A total of 86 corporate strategy, which will be in place from applications for consent declarations were in early 2021. We will publish the new strategy submitted to the HRCDC in 2019. The HRCDC by the end of 2020. convened nine times and made 23 decisions.

The HRB also worked with the Department of Health to establish a National Office for Research Ethics Committees which will also be supported by a team based at the HRB. Darrin Morrissey Recruitment will commence for the first posts Chief Executive in early 2020.

Future strategy During 2019, the HRB set out a clear plan for the Jane Grimson development of a future strategy. Chairperson

6 Health Research Board Annual Report 2019 Snapshot Secure data linkage and sharing of HRB The HRB funded a pilot activities project to design and develop the infrastructure during 2019 needed to share and link health data securely in line with legal and ethical requirements. The project, which will be led by the Irish Centre for High-End Computing (ICHEC) at NUI Galway, will also provide guidelines for the upscaling of the model.

Irish Psychiatric Units and Hospitals Census 2019

The HRB published the 10th national psychiatric census of patients in psychiatric units and hospitals. Horizon 2020 success

LENGTH OF STAY ON CENSUS NIGHT IRISH PSYCHIATRIC UNITS AND HOSPITALS CENSUS In 2019, Ireland secured almost 2019 2019 3,246,586 HRB STATISTICS IN-PATIENT DAYS 1,407 DAYS ACCUMULATED ON CENSUS NIGHT FOR THE AVERAGE ALL PATIENTS LENGTH OF STAY ON CENSUS NIGHT WAS 1,406.67 DAYS (MEDIAN 76 DAYS). 4% 18% (100 PATIENTS) % 2,308 19 % DECLINE 37 WERE NEW PATIENTS RESIDENT SINCE 2016 LONG-STAY, 65 WERE OLD i.e. had been in LONG-STAY, WERE LONG-STAY, ON 31 MARCH 2019 hospital continuously for between one and i.e. had been in i.e. had been in hospital hospital for five years for one year or more 50% OF ALL five years. % or more. on census night. LONG-STAY PATIENTS 17 i.e. those who had been in 65 hospital for one year or more were aged 65 and over. €17m UNDER 18S 58% 17% ONE-THIRD OF IN-PATIENTS 55% OF IN-PATIENTS SINGLE OF PATIENTS INVOLUNTARY WERE AGED 65 YEARS in Horizon 2020 (H2020) MALE AND OVER 18 HOSPITAL TYPE 33% 10% 83 ORGANIC MENTAL GENERAL HOSPITAL PATIENTS WERE funds. This represents 2.5% SCHIZOPHRENIA DISORDERS 78 PSYCHIATRIC UNITS U18 RESIDENT IN 16% 5 8% CHILD & RESIDENT IN 69% DEPRESSIVE MANIA 35% DISORDERS ADOLESCENT ADULT UNITS OF U18s WERE PSYCHIATRIC HOSPITALS/ FEMALE CONTINUING CARE UNITS UNITS of the available budget ON CENSUS NIGHT 30% AGED 17 YRS 37% INDEPENDENT/PRIVATE & PRIMARY ADMISSION PRIVATE CHARITABLE CENTRES 35 DIAGNOSIS OF AGED 16 YRS 42% DEPRESSIVE DISORDERS and was the largest Irish MAIN 27% 17% HRB Statistics Series 40 14 DIAGNOSIS DIAGNOSES AGED 15 YRS 17% OTHER SERVICES* OF EATING DISORDERS Irish Psychiatric Units and Hospitals 8% DIAGNOSIS 17 DIAGNOSIS 8% AGED 14 YRS OR YOUNGER 20.5% drawdown to date of H2020 Census 2019 Main Findings OF SCHIZOPHRENIA *(CENTRAL MENTAL HOSPITAL, ST JOSEPH’S 17 8% INTELLECTUAL DISABILITY SERVICE, CARRAIG MÓR) 20.5% DIAGNOSIS Antoinette Daly and Sarah Craig OF NEUROSES Research. Evidence. Action. funding. Per capita, Ireland

Improving people’s health through research and information Research. Evidence. Action. is the third highest recipient of health research funding from the EU.

Alcohol treatment figures for 2018

HRB report shows that two in three new cases were already Outputs, outcomes and emerging impacts dependent on alcohol when they presented for treatment for the The HRB Outputs, outcomes and first time. This means that more emerging impacts report, published

people are presenting when the by the HRB in December 2019, Outputs, outcomes and emerging impacts problem is already severe, which Results from HRB analyses the €47 million investment awards that completed in 2016 and 2017

makes treatment more complex in 187 awards completed during 2016

and recovery more difficult. and 2017. This investment led to 329

research-related posts, 187 policy

and practice influences, 10 patents,

5 licensed technologies, 2 start-ups, Maura Hiney

December 2019

59 industry collaborations, 113 new

research tools and methods, and 849 peer-reviewed publications.

Research. Evidence. Action. 7 Binge drinking and alcohol-related harm €38m Evaluation of €38m investment in HRB research leaders A HRB report shows that investing in high-potential researchers can have a real and lasting impact on the development of their research and international standing, and significant spill-over impacts on the careers of the researchers’ teams and the development of the respective Peer-reviewed research by HRB research disciplines within their institutions. staff found that: Speaking about their

• Monthly and occasional binge experience, one of the drinkers accounted for 62% research leaders said: of all drinkers; this group An evaluation of HRB investment consumed 70% of the alcohol in health research leaders ‘Because of the HRB awards, and accounted for 59% of the I’ve created a scientific group

harms in the population. which is generating research of global impact. That results • Dependent drinkers made in better science and better up just 7% of the drinking clinical care’. population and accounted for 27% of alcohol-related harms in Catherine Gill the population. Ailbhe Lamont Tonya Moloney

According to Dr Jean Long, Head of November 2019 the Evidence Centre at the Health Research Board: ‘Given the fact that most drinkers in Ireland engage in binge drinking, Drug treatment policies targeted at the whole figures for 2018 population are most appropriate HRB figures show a 50% to help reduce alcohol-related increase in cases treated for harms’. cocaine use between 2017 and 2018, which represents the majority of the increase in all treatment cases. There has been a consistent rise in treatment for cocaine use since 2013, highlighting a changing pattern of drug use Supporting Sláintecare during the recent economic recovery. Cocaine (22%) A number of HRB funding awards will is now rivalling cannabis contribute to the implementation of (23%) as the second most the Sláintecare programme. Dr Sara commonly reported Burke, the Principal Investigator on drug that people receive one of the projects said: treatment for. ‘This project will actively feed SLÁINTECARE international and national theory, IMPLEMENTATION knowledge, and experience into the STRATEGY Sláintecare implementation process. We will be co-designing a framework to ensure that regions can sustain the delivery of universal, integrated care that is responsive to their population’s health needs’.

gov.ie

8 Health Research Board Annual Report 2019 Digital animation series addresses young people’s mental health

The five-part series features the voices and stories of young people who have experienced anxiety, bullying, not fitting in, depression, and loneliness. Dr Helen Coughlan, Clinical Research Fellow at the Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI) said: ‘Findings from our research have shown that many young people are struggling with stress, anxiety, low mood, and a sense of isolation and disconnection from others. Often, they experience these issues privately and in silence without ever letting other people know’.

Drugs and road Increasing transparency user fatalities around HRB panel The HRB collaborated with reviews the Road Safety Authority (RSA) and with the Medical In 2019, as part of a pilot Bureau of Road Safety to programme, the first two examine the presence of observers attended a HRB panel drugs among road user review. The aim is to increase fatalities. Preliminary understanding among the results were presented research community about HRB by the RSA at its annual processes, and the initiative academic lecture in was widely welcomed by the October 2019. research community.

Helping to make every patient contact count

A new HRB-funded research project will help the Health Service Executive (HSE) make Two new HRB Board the most of every patient contact. Dr Maria members appointed O’Brien, Programme Manager for Making Every Contact Count, said: Professor Seamus Donnelly, Professor of Medicine at ‘Making Every Contact Count aims to address Trinity College Dublin and Dr the unsustainable pressure that chronic Tracy Cunningham, Clinical disease treatment puts on health services. The Head of Late Projects, HRB-funded research project led by Professor Oncology R&D, AstraZeneca, Molly Byrne of NUI Galway will ensure that the were appointed to the HRB implementation of the Making Every Contact Board in September 2019. Count programme is systematic and evidence- based, and thus supports health professionals to help patients achieve positive long-term behaviour change’.

Research. Evidence. Action. 9

Review of clinical research infrastructure in Ireland

HRB reviews €160m

investment in clinical

research infrastructure

According to Oonagh Ward, Final Report Oonagh Ward and Helen Kennelly HRB, lead author of the report: August 2019

hrb.ie ‘This report provides us with a much greater understanding the Irish clinical research HRB invests €8m in landscape, which will help to ensure that our future emerging investigators investments in this area are evidence-based and that they The 11 new emerging investigators will address identified needs and address a broad range of health areas, drivers of clinical research’. including breast cancer, type 2 diabetes, stroke, osteoarthritis, self-harm, sepsis, TB, clinical guidelines, gender differences in cardiovascular disease, and chronic obstructive pulmonary disease.

Dr Darrin Morrissey, Chief Executive, HRB said:

‘We want this investment to advance the skills and expertise of researchers, while at Psychiatric admissions and the same time generate research outcomes that have strong potential to impact on discharges people’s health, patient care or health policy’ The latest report from the HRB shows that there were 17,000 admissions to Irish psychiatric hospitals and units during 2018. Depression, schizophrenia, mania, neurosis and alcoholic disorders accounted for more than two-thirds of all admissions. European Drug Report 2019 IRISH PSYCHIATRIC UNITS 2019 AND HOSPITALS CENSUS 2019 The HRB provides Irish HRB STATISTICS data for overall European 2,308 4% analysis, and compares (100 PATIENTS) PATIENTS RESIDENT DECLINE the EU and the Irish drug ON 31 MARCH 2019 SINCE 2016 situation. 65 17% 55% ONE-THIRD 58% 17% OF PATIENTS OF IN-PATIENTS SINGLE OF IN-PATIENTS MALE WERE AGED 65 YEARS INVOLUNTARY AND OVER

33% 10% HOSPITAL TYPE SCHIZOPHRENIA ORGANIC MENTAL DISORDERS GENERAL HOSPITAL 16% PSYCHIATRIC UNITS DEPRESSIVE 8% DISORDERS MANIA 35% PSYCHIATRIC HOSPITALS/ CONTINUING CARE UNITS 30% INDEPENDENT/PRIVATE & PRIVATE CHARITABLE CENTRES MAIN DIAGNOSES 27%

OTHER SERVICES* 8%

*(CENTRAL MENTAL HOSPITAL, ST JOSEPH’S INTELLECTUAL DISABILITY SERVICE, CARRAIG MÓR)

Research. Evidence. Action. Professor Mary McCarron wins the first HRB Impact Award

The award recognises how her research has transformed health, care, and living environments for people ageing with an intellectual disability.

10 Health Research Board Annual Report 2019 BT Young Scientist

Dr Darrin Morrissey, Chief Executive, HRB, presents Laura O’Sullivan from Cork with the HRB Special Prize at the 2019 BT Young Scientist & Technology Exhibition.

Laura’s project demonstrated that artificial intelligence (AI) could play a role in cancer Drug-related deaths data screening programmes. published for 2017

More than one person died from drug overdose each day in 2017. Typically, these were male, aged in their 30s and 40s, and taking a mixture of drugs, many of which are legal, such as methadone, HRB staff present alcohol, or benzodiazepines. A research at Lisbon cocktail of drugs was present in three out of five poisoning deaths. Addictions 2019 Mixing drugs is known to cause conference more complications, and it also increases the risk of overdose. Dr Suzi Lyons, Ena Lynn, Dr Anne Marie Carew and Anne Doyle were among the HRB team presenting at the third European Conference on Addictive Behaviours and Dependencies.

Ones2Watch 2019 Competition

Dr Annalisa Montesanti, HRB, presents Dr Aisling Smith, from the Rotunda Hospital and the Royal College of Surgeons in Ireland (RCSI) with the HRB Ones2Watch 2019 Competition trophy. Dr Smith won the votes of her peers for the presentation of her research on heart function in babies born with 400 parents and children Down syndrome. participate in HRB-funded research project

The ENRICH programme involved a five-year investigation of a new service called the Upto2/Parent and Baby Programme which combines Treatment services for many different health and education- people with co-occurring Treatment for Services people with co-occurring substance use and mental health problems. A rapid realist synthesis. related parenting supports. The National Drugs Library HRB drug and alcohol substance use and mental programme was found to significantly evidence reviews 06

Treatment services for people with co-occurring substance use and health problems increase parental competence and mental health problems. A rapid realist synthesis. well-being. The HRB published results of this rapid realist review to feed into Ireland’s National Drugs Strategy 2017–2025, and to provide

Improving people’s health through research and information information to help better integrate mental health and substance use services.

Research. Evidence. Action. 11 HRB at major international disability conference

Dr Sarah Craig, Head of National Health Information Systems, HRB, co-presented a session at the International Association for the Scientific Study of Intellectual and Developmental Disabilities conference entitled Lessons learnt from the Irish National Intellectual Disability Database and future plans. ‘Approximately 1,300 people attended the four-day conference’, said Dr Craig. ‘It was interesting to see more papers at the conference in the area of big data, and that the HRB’s National Intellectual Disability Database (NIDD) is one of a very small number of data sources in the world that are dedicated to intellectual disability’.

Health Research €750,000 Consent Declaration bequeathed Committee for Parkinson’s research The HRB Secretariat for the Health Research Consent Declaration Committee (HRCDC) opened its doors for business in January 2019. A total of The HRB, in partnership 86 applications were submitted to the HRCDC with the Medical Council, in 2019. The HRCDC convened nine times launched an award funded and made 23 decisions. Twenty applicants by a bequest from the received a consent declaration (with or without late Mr Patrick Quinn conditions attached), and two decisions for research that would were deferred pending further information. help people living with One decision was to not make a consent Parkinson’s disease or declaration, which was overturned by an people caring for them. independent appeal panel.

Supporting national change for open research National Framework The HRB fully endorsed the National Framework on the Transition to an on the Transition Open Research Environment and will work closely in partnership with to an Open Research other stakeholders to prepare the National Action Plan. Environment

Patricia Clarke, Programme Manager, HRB, and Co-chair of the National Open Research Forum said:

‘The National Framework is a clear statement of intent by the Irish research community to take practical steps to embed open research in Ireland and to ensure that the research system moves in a common direction’.

12 Health Research Board Annual Report 2019 Prepared by the National Open Research Forum for the Innovation 2020 Implementation Group July 2019 01 1

Key deliverables in line with HRB strategy 2016 - 2020

Research. Evidence. Action. 13 The HRB Strategy 2016–2020 charts a clear This annual report highlights key achievements course for what the organisation will do over made during 2018 in line with the strategy that time period. objectives, and it showcases some examples of significant outcomes and successes.

Figure 1. Core elements of HRB strategy 2016-2020

Our three focus areas and enablers are complementary and interdependent, and we will pursue them simultaneously throughout the period of the strategy.

FOCUS AREA 1 FOCUS AREA 1 ENABLER A Address major Support exceptional ENABLER ENABLER health challenges researchers and leaders A B FOCUS AREA 2 ENABLER B Support healthcare Build a strong enabling interventions environment

FOCUS FOCUS AREA AREA FOCUS AREA 3 ENABLER C 2 3 Address the research Enhance needs of the Irish health organisational ENABLER and social care system performance C

Focus areas Enabling themes

As the lead national agency for health research Progress in the three focus areas will be enabled in Ireland, we have a responsibility to invest in and maximised by policies and actions that affect the future as well as to meet the needs of today’s all three of these areas. This will be achieved by: health system. Great ideas are the basis for • Supporting the exceptional researchers and many advances in healthcare. We have defined leaders we need to undertake high-quality the following three distinct but complementary health research and generate evidence. areas of focus that we consider to be the most appropriate to lead the HRB and its community • Building a strong enabling environment for over the period from 2016 to 2020 and beyond: health research in Ireland and ensuring that we understand the outcomes and demonstrate the • Address major health challenges impacts of our investments. • Support healthcare interventions, and • Ensuring that our policies and governance are • Address the research needs of the Irish health robust and are founded on best practices. and social care system.

14 Health Research Board Annual Report 2019 Focus area 1

Address major health challenges

2019 Objectives: • Co-funded one large Investigator Award and one Research Career Re-entry Fellowship, • Support high-quality, investigator-led, with a combined value of €1.2 million, under internationally competitive research. the Science Foundation Ireland (SFI)-HRB- • Develop and implement co-funding Wellcome Research Partnership. opportunities with international agencies and • Participated in three joint transnational institutions. calls in 2019 under the HRB strategy for engagement in European Union (EU) Key items delivered in 2019 research. These included calls in the Joint Programme in Neurodegenerative Diseases • Made 33 awards worth €16.3 million in Focus (JPND), the EU Joint Programme in Rare area 1. Of the €16.3 million awarded in this Diseases (EJP RD), and the ERA-Net on area, €5.4 million was leveraged from other Personalised Medicine (ERA PerMed). sources. • Invested in two awards worth €3.8 million, • Funded two awards worth €1.7 million for with the HRB contributing €0.7 million of this international collaboration under the US- total. The first of these awards is focused Ireland R&D Partnership. on developing neuroimaging tools for • Funded 25 awards worth €9.1 million under neurodegenerative diseases and the second the 2019 Investigator-Led Projects scheme. is focused on linking and analysing registries for rare diseases across Europe. • Opened a call in September 2019 for the 10th HRB-Health Research Charities Ireland • The HRB also worked to prepare five new (HRCI, formerly MRCG) Joint Funding transnational calls in neurodegeneration, Scheme. health nutrition, therapies for rare diseases, and personalised medicine, which will open • Made two awards worth €0.6 million under in 2020. a new funding instrument focused on Parkinson’s disease research in partnership with the Medical Council, funded by a bequest from the late Mr Patrick Quinn. 33 awards, worth €16.3m, were made in this focus area.

Research. Evidence. Action. 15 Case Study 1: A common approach to research integrity

In 2019, the HRB became a partner in an EU project to develop a “toolbox” of standards and guidelines that help cultivate research integrity.

‘Research integrity means Standard Operating Professor Anita Maguire, Chair many things,’ said Dr Maura Procedures for Research of Ireland’s National Forum on Hiney, Head of Post-award Integrity (SOPs4RI) is a multi- Research Integrity, added: and Evaluation, and the HRB country project funded by the contributor to this project. European Commission. The ‘Ireland needs and wants to be ‘It’s a huge area that goes from aim of SOPs4RI is to develop fully aligned with its research the micro to the macro level, evidence-based standard counterparts in Europe. Having spanning individual research operating procedures (SOPs) a national RFO as an active projects and the very nature of and guides that RPOs and RFOs partner in this project ensures scientific endeavour’. can draw on when developing that the work of the National governance arrangements Forum on Research Integrity is ‘Research integrity is essential to promote strong research informed by the latest evidence in order to build public trust integrity cultures. and thinking at an international in science. It also has really level. We are already aligned important contributions to with the European Code of make to reducing research Dr Maura Hiney, continued: Conduct for Research Integrity, waste, to avoiding duplication ‘The ultimate output of the so integrating the outputs of of research effort, and to SOPs4RI project will be an this project, as they emerge, in raising standards. online, freely accessible an Irish context is a natural next and easy-to-use evidence- step for us’. ‘However, research-performing based “toolbox” that can help organisations (RPOs) and RPOs and RFOs to cultivate The project runs from 2019 to research funding organisations research integrity and reduce 2022. (RFOs) sometimes struggle to detrimental practice in the know whether the systems they research that they support. are putting in place are really The HRB wants not just to be a the most effective to promote part of the broader solution for and protect good research research integrity practices, but practices and that’s where this also to meaningfully contribute project comes in.’ to enabling positive change.’

16 Health Research Board Annual Report 2019 Case Study 2: Supporting cutting-edge research – €8.7 million for 24 new Investigator-Led Projects

In 2019, the HRB funded 24 new which meant that almost all Dr Creely added: Investigator-Led Projects. This of the applications had 3 scheme supports innovative separate reviewers. Following ‘The breadth and diversity of and internationally competitive analysis of their scoring, 76 these research projects really research that addresses health applications progressed through showcases the capabilities of challenges for society. There are an international review panel the research community in two thematic streams, the first process. There were two Ireland’. in patient-oriented research, separate panels, one to address and the second in population each thematic stream. Following This is the second of three calls health and health services the panels’s deliberations, the planned during the HRB Strategy research. final 24 sucessful projects were 2016–2020 period, with the third selected’. expected in 2020 or 2021. The According to Dr Caitriona HRB plans to invest €18 million Creely, Programme Manager, The successful projects will in the Investigator-Led Projects HRB: address topics including scheme during the lifetime of investigating new antimicrobial the strategy and a further €8.25 ‘HRB Investigator-Led Projects agents to treat wound million in 2021. is a highly competitive scheme, infections, exploring the and we always see a strong therapeutic potential of sensory interest from researchers in stimulation for Alzheimer’s ‘The breadth and each round. There were 133 disease, evaluating services eligible applications in 2019. provided for women who diversity of these In order to fairly assess such a experience recurrent pregnancy research projects large number of applications, loss, and studying how patients really showcases the we contacted almost 2,400 with advanced chronic kidney potential international reviewers. disease (CKD) transition to capabilities of the Just over 500 of these accepted kidney failure and dialysis, and research community in our invitation to review projects, how this might be prevented. Ireland’.

Research. Evidence. Action. 1717 Focus area 2

Support healthcare interventions

2019 Objectives: Research Partnership. This partnership connects HRB-TMRN to a diverse group of • Support the design, conduct, and evaluation researchers from a variety of disciplines to of intervention studies. work on novel aspects of trials methodology. • Facilitate the coordination, enabling • Supported the Irish Research Nurses mechanisms, and national/international Network to launch its publication Count collaborations that improve the volume, me in, based on a national survey of clinical quality, relevance, and impact of trials and research nurses (CRNs) and midwives working intervention studies in Ireland. in a variety of settings (e.g. universities, hospitals, industry, and primary care) in Key items delivered in 2019 Ireland. • Monitored the progress of 21 active DIFAs, • Opened the next round of the 2020 Definitive with 421 participants enrolled on studies to Interventions and Feasibility Awards (DIFA). date. These awards are designed to boost academic-led clinical trials and interventions and create a pipeline of research that can go on to become full-scale interventions in the future. • Conducted a successful interim review of HRB Clinical Research Coordination Ireland (HRB-CRCI). The HRB-CRCI is a €3.4 million investment by the HRB. • Completed a review of Cancer Trials Ireland, in order to inform the HRB’s future €3.4m investment in cancer trials in Ireland. investment by the • Provided supplemental funding of €75,000 to support the HRB-Trials Methodology HRB in HRB-CRCI. Research Network (TMRN) to join the Medical Research Council (MRC) Trials Methodology

18 Health Research Board Annual Report 2019 Case Study 3: The People’s Trial – research empowered by the public

Does reading a book in bed make a difference to sleep in comparison to not reading a book in bed?

‘We want The People’s Trial to stages of The Peoples Trial, and The researchers are now help the public learn about participants from 43 countries analysing the data, and have randomised trials, to understand were randomised in the trial. worked with the public to why they matter, and to be identify how they would like to better equipped to think The HRB-TMRN team used see the results disseminated critically about health claims,’ the project website, www. and shared, including among said Professor Declan Devane, thepeoplestrial.ie, and social the more than 612 people from Director of the HRB-Trials media to engage and interact 47 countries who responded to Methodology Research Network. with the public. The site opened this stage of the study. The trial in August 2019 and more than results are expected to be made ‘And equally importantly, The 155 potential trial questions public in early 2020. People’s Trial will also help were received. These questions researchers learn about how informed the basis of The Speaking about the HRB- best to involve the public in the People’s Trial. The question for funded initiative, Oonagh steps of a trial process. This in the trial was selected by the Ward, Programme Manager, turn will help influence other public, following two rounds of Infrastructure, Interventions and trials to be better designed and voting. The winning question Networks said: implemented in the future’. was: “Does reading a book in bed make a difference to sleep ‘Having a trial designed by the The brainchild of the HRB-Trials in comparison to not reading a people for the people is a simple Methodology Research Network book in bed”? yet excellent example of how at NUI Galway, The People’s to involve and engage people in Trial offered ordinary people The public then decided on health research. It builds trust, the chance to participate in the trial design and how the interest and an understanding scientific research. Public question was answered; they of the process of developing participants decide all the major also took part in the trial, and health interventions. All stages steps in a randomised trial and decided on the best way to of this project were interesting any member of the public was disseminate the trial findings. and innovative – even the final eligible to take part. No special stages, which involved asking skills or training were needed, as Overall, 950 people took part trial participants how they would the HRB-TMRN website for the in the trial, with 476 people like HRB-TMRN to disseminate initiative explains everything you assigned randomly to reading and share The People’s Trial need to know to get involved. a book in bed and 474 people findings. We look forward to assigned randomly to not seeing the trial results soon’. In total, participants from 59 reading a book in bed. countries took part in the

Research. Evidence. Action. 19 Case Study 4: Blood clots and pregnancy

‘Blood clots cause more international trial that will HRB Definitive Interventions maternal deaths in the UK recruit more than 500 women, and Feasibility Awards scheme and Ireland as a direct result with Irish patients accounting was designed to boost research of pregnancy than any other for approximately 100 of these activity in clinical trials and condition’, said Dr Fionnuala women. interventions. Ni Áinle, a consultant haematologist at the Mater The study will compare two ‘Investigators such as Misericordiae University doses of clot-preventing Professor Ní Áinle, working Hospital and University College medication recommended in partnership with clinical Dublin, and the Principal by current guidelines for research infrastructures in Investigator on the HRB-funded pregnant women who have Ireland, have demonstrated our HIGHLOW study. had a previously diagnosed ability to deliver high-quality blood clot. The study aims studies both nationally and ‘Blood clots can cause serious to determine which dose is internationally’, she added. ill health, and pregnant women most effective in preventing have an increased chance of a new blood clot, and which developing blood clots. We dose is the safest in terms of ‘With the support also know that women with minimising side effects such as a previous blood clot have bleeding. of the HRB, the Irish a higher recurrence risk in team has rapidly pregnancy. Dr Ni Áinle continued: become a key player in

‘In fact, the risk is so high that ‘Ireland is on track to recruit the field of academic clot-preventing medication is a substantial proportion of all research in venous warranted during the entire patients to this international thromboembolism’. pregnancy and for six weeks study, which is a tremendous after delivery. Unfortunately, achievement given the relative the scientific literature doesn’t size of our population. have clear evidence on what might be the best medication ‘With the support of the HRB, and the best dose of that the Irish team has rapidly medication to prescribe’. become a key player in the field of academic research in venous That is where the HIGHLOW thromboembolism’. study comes in. It is supported through the HRB’s Definitive Oonagh Ward, Programme Interventions and Feasibility Manager, Infrastructure, Awards scheme. This research Interventions and Networks, at forms part of a larger the HRB commented that the

20 Health Research Board Annual Report 2019 Focus area 3

Address the research needs of the Irish health and social care system

2019 Objectives: > Renewed the Collaboration Agreement for Phase III of the Research • Support research that addresses questions Collaborative in Quality and Patient of national relevance for clinical and Safety Awards Scheme (RCQPS) at a population health practice and for health total cost of €0.3 million (€42,000 to services management, as well as the the HRB). This scheme is run jointly translation of research results into policy with the Health Service Executive (HSE) and/or practice. and the Royal College of Physicians of • Provide high-quality, timely, and relevant Ireland (RCPI). data for policy, service planning, and > Awarded €0.6 million to two RCQPS research through the HRB’s National Health projects. The cost to the HRB is €0.27 Information Systems (NHIS). million, with equal co-funding from the • Promote and support evidence synthesis HSE. and knowledge translation activities in order > Awarded €0.2 million through the to help policy-makers, service planners, Cancer Nursing Research Awards to and providers make evidence-informed a pilot study on of an integrated care decisions. model for patients receiving oral anti- cancer agents in the community. Key items delivered in 2019 > Renewed funding worth €0.2 million up to 2021 to Dementia and • Made 18 awards worth €4.3 million in Focus Neurodegeneration Network Ireland area 3. Of the €4.3 million awarded in this (DNNI). area, €1 million was leveraged from other sources. Details of the 18 awards are as > Working jointly with the Irish Cancer follows: Society, made one Cancer Nursing Research Award worth €0.16 million. > Invested €1.3 million in our Applied Partnership Awards scheme. A total • Completed successful interim reviews of the of six awards were made in 2019, with progress of The Irish Longitudinal Study on co-funding of €256,000 provided by Ageing (TILDA) and Research Leaders 2015 healthcare organisations. Awards. > Made seven awards worth €1.9 million • Jointly organised a workshop on dementia for innovative Secondary Data Analysis research with the HSE National Dementia Projects. Office. The event was hosted by the

Research. Evidence. Action. 21 18 awards worth €4.3m made in Focus area 3.

Department of Health Ageing Unit, and the • Published four issues of Drugnet Ireland. outputs were published on the HRB and HSE • Trained more than 900 people from websites. approximately 300 services on the LINK • Published one HRB National Health system for the National Drug Treatment Information System (NHIS) annual report Reporting System and the National Ability and one census report from the National Supports System. Psychiatric In-patient Reporting System (NPIRS). The librarians at the HRB National Drugs • Published six national bulletins, generated Library (www.drugsandalcohol.ie) updated six eight infographics, and produced 45 fact sheets on the drugs situation in Ireland quarterly performance indicator reports and produced new fact sheets on ecstasy and to provide clear and concise information smoking. They created a new webpage on to help policy-makers and service planners alcohol, drawing together key resources in one make informed decisions about service accessible place, and ensured that Irish drug- planning in the area of drugs, alcohol and related publications published in 2019 were disability. made available in the electronic public library. • Completed and submitted 16 peer-reviewed journal articles based on NHIS data. Eleven were published in 2019, with the remaining The librarians actively engage with stakeholders five expected to be published during 2020. through course visits, the community of practice on dual diagnosis, and the National Drugs • Collected data on behalf of the Road Safety Forum. The HRB National Drugs Library website Authority (RSA), the National Directorate for (www.drugsandalcohol.ie) had 164,855 user Fire and Emergency Management, and the sessions during 2019, and 5,648 profile visits to National Office for Suicide Prevention. its Twitter feed. • The HRB and the Department of Health’s Drugs Policy and Social Inclusion Unit jointly hosted the second annual National Drugs Forum at the Aviva Stadium, Dublin in More than 900 people from November 2019. approximately 300 services • Published five evidence reviews and completed five evidence briefs. have been trained on the LINK system

22 Health Research Board Annual Report 2019 Case Study 5: HRB data – more than the sum of its parts

HRB staff are using data from ‘The varied nature of coroners’ fortunate to leverage the the organisation’s information cases means that there is expertise of HRB researchers, systems and research to potentially a range of groups who already extract better understand fire deaths, that can benefit from a more information from coronial suicide, road traffic collisions, in-depth investigation. We files to gain insight into the and drownings. already engage with other circumstances of Irish fire organisations such as the fatalities. We hope to continue In 2019, the HRB published the National Office of Suicide working with the HRB to use first research paper on fire Prevention, the Road Safety these learnings to further deaths in Ireland. It revealed Authority and others to gather reduce fire deaths in Ireland’. that alcohol was present in data relevant to their work, more than half of fire-related so we were delighted to work Dr Craig continued: deaths reported. with the National Directorate for Fire and Emergency ‘It is fantastic that HRB ‘The HRB has been gathering Management to analyse expertise can be leveraged data from coronial files for a specific data on fire fatalities. in this way. We work with the number of years’, said Dr Sarah Road Safety Authority (RSA) Craig, Head of National Health ‘This is the first time that data and the Medical Bureau of Information Systems (NHIS), in relation to fire fatalities from Road Safety to enable more HRB. ‘We use the coronial files all Coroner sites in Ireland in-depth analysis of toxicology as one part of our information have been analysed’, according results related to road traffic gathering about drug and to Seán Hogan from the fatalities. And work is ongoing alcohol-related deaths for the National Directorate for Fire with the National Office for National Drug-Related Deaths and Emergency Management Suicide Prevention to enhance Index. at the Department of knowledge about deaths due Housing, Planning and Local to suicide’. Government. ‘We have been

Research. Evidence. Action. 23 Case Study 6: Getting the most from existing research and social care data

In 2019, the HRB funded seven Service (PCRS) datasets. The also contribute to improving projects in the first round of its international datasets identified systems for appropriate new Secondary Data Analysis included the UK Biobank, controlled drug prescribing, to Projects (SDAP) scheme. The the British Cohort Study, the improving well-being among HRB will invest almost €1.8 National Child Development adolescents in Ireland, to million in this scheme over the Study, the Longitudinal Study creating better policies to lifetimes of these projects. The of Young People in England, prevent chronic conditions, and scheme is designed to help the English Longitudinal Study to understanding the disparities health researchers make the of Ageing, Understanding in gender-related health best use of existing health and Society, the British Household outcomes in chronic kidney social care data. This is in line Panel Survey, Global Burden disease. with a key action identified of Disease, and the Adult in the HRB Strategic Plan Psychiatric Morbidity Survey. In addition to secondary (2016–2020) to promote the data analysis, three of the secondary analysis and deeper All of the projects identified projects will develop tools to exploitation of existing data knowledge users for whom make datasets accessible and sources. the results could be used to more widely available to other improve policy and practice. researchers and knowledge ‘There are so many datasets users. These include a web tool, out there that are rich veins of The HSE is an important a data map, a data dictionary, information with the potential knowledge user; other an anonymised public-facing to inform other areas of health knowledge users include the portal, and the integration of and social care,’ said Dr Anne Health Information and Quality patient-reported outcomes Cody, Head of Pre-Award at the Authority (HIQA), the Irish measures (PROMs) into an HRB. ‘This funding ensures that Kidney Association, the All- electronic health record (EHR). these datasets are better used Ireland Institute for Hospice in order to deliver high-quality, and Palliative Care, and the Irish high-impact evidence for policy Hospice Foundation. All of the projects and practice’. The HRB-funded projects identified knowledge The most commonly identified will contribute to improving users for whom the datasets in applications to safety in social care results could be used the SDAP scheme were The settings, to creating better Irish Longitudinal Study on understanding of the future to improve policy and Ageing (TILDA), Growing Up needs of palliative and end- practice. in Ireland (GUI), Hospital In- of-life care in Ireland, and to patient Enquiry (HIPE), and identifying risk of maternal and Primary Care Reimbursement neonatal morbidity. They will

24 HealthHealth Research Research Board Board Annual Annual Report Report 2019 2019 Enabler A €13.8m Made 99 awards, Support exceptional worth €13.8m researchers and under Enabler A. leaders

2019 Objectives: > Through the Fulbright-HRB Health Impact Awards, provided an opportunity • Attract the best people to health research for three Irish health researchers to take by supporting excellent PhD training up placements for a period of three/ programmes. six months to develop collaborations • Provide opportunities for career with US colleagues. The total funding development for postdoctoral researchers involved was €0.3 million. and emerging investigators. • Updated the Health Research Careers • Work with higher education institutions, Framework. Hospital Groups, and the HSE to identify, • The HRB Irish Clinical Academic Training develop, and support leaders in health (ICAT) Programme (established with research. Wellcome) recruited the third cohort of • Work with national and international new doctors to participate in a PhD training partners to facilitate training and exchange programme for clinicians. Under the scheme, opportunities that address skills gaps. 40 clinicians will be trained between 2016 and 2021.

Key items delivered in 2019 • The HRB-funded Structured Population and Health-services Research Education • Made 99 awards worth €13.8 million under (SPHeRE) programme took in a cohort of 13 Enabler A, which included: PhD students (four HRB-funded students and > Supported 82 Summer Student nine students funded from other sources). Scholarships, worth a total of €1.9 • Launched a call for Research Leader Awards, million. with awards to be made in 2020. > Invested €4.5 million in three awards • Launched a call for Emerging Clinician under the new Collaborative Doctoral Scientist Awards, with awards to be made in Awards in Patient-focused Research 2020. scheme for thematic cohorts integrating • Completed a successful interim review of health and social care professionals with the Collaboration in Ireland for Clinical academic health researchers. Effectiveness Reviews (CICER) programme. > Awarded 11 Emerging Investigator CICER is a five-year €2.5 million investment Awards, worth a total of €8.31 million. by the HRB in conjunction with HIQA. > Provided reintegration funding of €0.2 million to a Cancer Prevention Fellow.

Research. Evidence. Action. 25 Case Study 7: HRB investments in Ireland’s research leaders under the microscope

‘Since 2004, the HRB has published in international publications we generate. But invested €38 million to support scientific journals better clinical care because the development of leaders in • 149 rewards and only through research and the research in both the academic recognitions bestowed by protection of research can you and clinical environments’, scientific peers get the time to be an absolute said Dr Catherine Gill, HRB • 197 education and training expert in the clinical field Programme Manager in Post- initiatives delivered you’re engaged in’. award and Evaluation. • 49 instances globally of evidence produced by ‘The findings from the report ‘In 2019, we conducted detailed HRB leaders being cited in will inform how we fund quantitative and qualitative clinical guidelines. career development in our analyses of that investment. next strategy’, noted Dr Gill. In essence, we looked at what The leaders’ comments ‘The report has already driven works, what doesn’t, and what about their experience of change in the HRB’s approach needs adjustment. Those HRB support reflects the to health research careers, with results were published in An impact the award had on their the development of a separate evaluation of HRB investment in careers, both nationally and career track for health and care health research leaders’. internationally. practitioners. This recognises the different challenges faced A total of 25 high-potential ‘I really do think this [award] by clinicians and academics, researchers in clinical, enables people to go beyond and ensures that potential population health and health where they could’ve expected research leaders among the services research were funded in their careers’. health and care professional via the Research Leaders community have an opportunity Awards and Clinician Scientist ‘My career has changed to compete for funding’. Awards. The analysis found beyond all recognition from that they become leading the way it was 11 or 12 years

investigators in their discipline, ago, to being an academic

that they mentor and develop leader in my own field, in others and drive evidence use the university, in the country in policy and practice in their and internationally … so truly An evaluation of HRB investment in health research leaders discipline. Their awards led to: transformative from my point of view’.

• 119 research-related

positions being funded ‘Because of the HRB awards,

• €28.5 million in additional I’ve created a scientific group funding leveraged which is generating research

• 190 policy and practice of global impact. That results Catherine Gill Ailbhe Lamont influences developed in better science and better Tonya Moloney

• 133 collaborations forged clinical care. Better science November 2019

• 809 peer-reviewed papers because of the grants and

26 Health Research Board Annual Report 2019 Case Study 8: Professor Mary McCarron wins the inaugural HRB Impact Award

Pictured L to R: Dr Darrin Morrissey. HRB. Professor Mary McCarron, TCD, and Ms Eilis Walsh, wife of the late Dr Dermot Walsh, HRB, whom the HRB Impact Award is in memory of.

The HRB Impact Award delivering better health and care, could not have achieved any of was created to recognise creating award-winning housing this without the many colleagues a researcher or health projects, and driving policy change who have worked with me, and professional who has made, that is transforming the lives of the students, research fellows or is making, an outstanding people with intellectual disability as and interviewers who have made contribution to research that they age.’ all of the data collections and has had a significant impact on analyses possible. people’s health or on health ‘The approach she has taken, policy or practice. involving this community and ‘Most of all, I am grateful to giving them a real voice, is also the people with intellectual Professor Mary McCarron, having global impact. Many of disabilities, their families and Professor of Ageing and her findings, and the change the service providers who have Intellectual Disability at the she is leading, are directly gone above and beyond to School of Nursing and Midwifery, transferable to the general collaborate with us, support us, Trinity College Dublin, is the first population who are ageing guide us, and, ultimately, to give winner of this award. too, which is attracting major us answers to help shape ageing interest both nationally and for people with an intellectual Presenting the award, Dr Darrin internationally.’ disability in Ireland. Not to Morrissey, Chief Executive, HRB mention more questions to said: Accepting the HRB Impact investigate. Award, Professor Mary ‘The HRB Impact Award recognises McCarron said: ‘The legacy I want to leave is people who use their research that we have the services and to create real changes in health ‘It is a very humbling moment to supports available so that every and care. Professor McCarron receive this level of recognition. person with intellectual disability has an incredible track record I am so appreciative of the will experience happy and of translating her research into support I have received from healthy lives in old age’. practice. As a result, she is now is the HRB over so many years. I

Research. Evidence. Action. 27 Enabler B

Build a strong enabling environment

2019 Objectives: > A report on the outputs and outcomes of HRB awards that completed in 2016 • Work with the Department of Health and key and 2017, in order to better understand stakeholders to shape the national research what is emerging from our funded agenda in relation to health and social care. research. • Provide leadership to shape the review, • Contributed to the Corporate Enabling of conduct, and governance of research. Clinical Research initiative to identify and • Contribute to, and benefit from, international address the challenges of sponsoring clinical developments in policy, regulation, and research studies in the areas of governance, legislation relevant to health research and contracts, insurance, operations, financial healthcare in Ireland. resources, engagement with the health sector, training, and support. • Invest in research infrastructure to promote excellence, critical mass, and coordination in • Published a new HRB policy on clinical trials order to support HRB strategic focus areas and interventions governance. and the wider health community. • Worked with the OECD Global Science • Support Irish health researchers to Forum on an international activity for participate in Horizon 2020 (H2020) and optimising the operation and use of national other European research programmes. research infrastructures. • Published a new HRB policy on research data Key items delivered in 2018 management and sharing. • Actively promoted public and patient • Invested €0.4 million in a proof of concept involvement (PPI) in research. This included: of a data environment for health and related research under the data, access, storage, > Working with the five PPI Ignite Awards sharing and linkage (DASSL) model. to coordinate their capacity building for PPI in research in higher education • Published three key evaluation reports on: institutions > An in-depth review of the clinical > Doubling the number of public reviews, research infrastructure landscape in with full coverage of 133 applications to Ireland to provide evidence for the the Investigator-Led Projects design of a model of future clinical infrastructure investment > Having PPI members on a selection panel. > An evaluation of HRB investment in health research leaders (specifically • Took a leadership role in Open Science in the Research Leader Awards and the Ireland with a number of initiatives. This Emerging Clinician Scientist Awards), included: in order to inform future calls in these > Chairing a revision of the national areas research integrity policy, Ensuring

28 Health Research Board Annual Report 2019 86 applications were handled by the HRCDC in its first year

Integrity in Irish Research, on behalf 35% of female applicants and 34% of of the National Forum on Research male applicants successful Integrity. > Conducting an audit of post-award > Developing HRB Open Research, processes the HRB’s open research publishing > Hosting a meeting of a global forum for platform, to include indexing on funders under the banner of ‘Ensuring PubMed, the launch of three collections Value in Research’. The Forum allows in ageing populations, research members to develop best practice in a methodology and maternal/child health, variety of areas, from the selection of and the launch of a new article type, the call topics to the reporting of outputs Registered Report. and outcomes. > Conducting two training events to raise • Worked within the Science Europe Working awareness of FAIR (findable, accessible, Group on Research Data to publish the interoperable, reusable) research data. Practical Guide to the International > Jointly chairing the National Open Alignment of Research Data Management. Research Forum (NORF) with the Higher • Established the Secretariat of the Health Education Authority (HEA). Research Consent Declaration Committee • Launched the National Framework on the (HRCDC) which in its first year: Transition to an Open Research Environment, > Handled a total of 86 applications to the which will act as the foundation for a HRCDC. National Action Plan for the transition to an open research environment in Ireland, > Convened the HRCDC nine times jointly supported by the Department of and made 23 decisions (20 applicants Business, Enterprise and Innovation and the received a consent declaration; two Department of Education and Skills, and decisions were deferred, and one was endorsed by four Government Departments rejected by the HRCDC). and 17 agencies and research organisations • Confirmed Irish membership of the EU Public across Ireland. Health Programme through the Department • Continued to improve HRB grant processes. of Health, affording Irish researchers the This included: opportunity to undertake policy- and practice-relevant health research. > Achieving excellent gender balance both on HRB selection panels, with 49% • Chaired the International Consortium female and 51% male representation, for Personalised Medicine (ICPerMed), a and in applicants’ success rates, with consortium of EU funding bodies established

Research. Evidence. Action. 29 €16.9m leveraged by Irish researchers in funding from H2020 programmes

by the European Commission under the and evaluation of a comprehensive, H2020 programme. multilevel intervention targeting both clinical and non-clinical mental health • Contributed to the health perspective in issues. preparations for Horizon Europe, the EU Framework Programme 2021–2027. – NUI Galway leading the AutoCRAT project, which focuses on the use of • Supported Irish researchers to compete for automated cellular robot-assisted EU funding: technologies for translation of > Irish researchers leveraged €16.9 million discovery-led research in osteoarthritis. in funding from H2020 programmes in – NUI Maynooth leading the SHAPES 2019. project, which focuses on smart and > Eighteen Irish projects successfully healthy ageing through people engaging competed for funding in the H2020 in supportive systems. The project also Health Challenge, with five projects addresses issues of ageing, ehealth and being led by Irish researchers. Highlights well-being, and social inclusion. This is include: the largest ever H2020 health grant (€21 – Three successful projects in artificial million) led by an Irish university. intelligence (AI) after cancer treatment, > Other successful projects cover areas with Waterford IT leading the FAITH, including the use of big data and AI federated artificial intelligence solution to improve quality of life for cancer for monitoring mental health status survivors, therapies for drug-resistant after cancer treatment, project. bacterial pneumonia, heart failure, – UCD leading the ImpactDiabetesB2B novel neurodegenerative therapies, project, a low-resource system of care irritable bowel syndrome, appropriate intervention for appropriate gestational use of caesarean section, integrated weight gain and improved postnatal care, and smart living homes. outcomes using personalised health coaching delivered via a smartphone App. – UCC leading the MINDUP project, which focuses on mental health promotion and intervention in occupational settings, as well as project development, and implementation

30 Health Research Board Annual Report 2019 Case Study 9: Ensuring value in research – how the HRB is playing its part

It was relatively straightforward to agree on the principles. The difficult bit is to make them come to life in your own processes and policies.

Everybody is grappling with the same issues, and learning from, and with, each other is really powerful.

Since 2017 a group of health proportionate to risks. Dr Anne Cody, Head of Pre- research funding agencies and • Aim to ensure that Award, explained: policy-setting organisations complete information on from around the world has research methods as well ‘It was relatively met regularly to discuss as findings from studies are straightforward to agree on common challenges, share accessible and usable. the principles. The difficult bit experience, and collaborate. is to make them come to life This group comes together The HRB has been a member in your own processes and under the umbrella of the of the EViR Funders’ Forum policies. The EViR Funders’ Ensuring Value in Research since it was established Forum comprises large and (EViR) Funders’ Forum. The in 2017.The HRB is also small funders, those with a group has developed a set of represented on the EViR specific thematic remit, and guiding principles that oversee Steering Group. In March 2019, those covering all kinds of all of the members’ efforts and the HRB hosted a meeting health research, working in activities as research funders. with 55 representatives many different countries and from 20 funders and nine research systems. Everybody is As funders, EViR members other organisations in ten grappling with the same issues, maximise the value of the countries. This was also an and learning from, and with, research they fund when they: opportunity for other Irish each other is really powerful. stakeholders, including Dr I’m always energised after a • Set justifiable research Ana Terres, Head of Research, meeting, with lots of new ideas priorities. Health Service Executive; Dr about how we can increase the • Require robust research Avril Keenan, CEO of Health value of HRB funding’. design, conduct and Research Charities Ireland; and analysis. Professor Bernie Hannigan, • Seek to ensure that HRB Board member, to hear research regulation more about the work of the and management are EViR Funders’ Forum.

Research. Evidence. Action. 31 Case Study 10: Driving culture change for research data management

In November 2019, the HRB should provide maximum respect the terms of consent, published a new policy support to researchers and as well as manage security or dedicated to the sharing and host institutions in order to safeguard against other risks. management of research data. implement the HRB policy, For these reasons, the degrees The new policy aims to ensure and it should also promote of data openness may justifiably that research funded by the alignment of research data vary, including fully open, HRB is transparent, equitable, policies and approaches from restricted/governed access of high quality, and can be Irish research institutions and or strictly confidential access. reused by others. In line with funders’. However, in all cases, high- best international practice, quality metadata must be made HRB-funded researchers are While funder policies are available’. now required to develop data important drivers, there is management plans (DMPs) growing recognition that During 2020 the HRB looks to consider how data are credit for data sharing strongly forward to working with other collected, managed and stored increases the incentive for key stakeholders to deliver to a high standard from the very researchers to make their best practice implementation beginning of a research project. data open. Sharing research approaches. data also brings with it some Professor Jane Grimson, Chair concerns and challenges for This policy will apply to all new of the HRB Board said: researchers. HRB funding calls launched from 1 January 2020 onwards. ‘Data governance and Dr Mairead O’Driscoll, Director stewardship are fundamental of Research Strategy and to good research practice. Funding, HRB commented: The HRB is working to establish a supportive and ‘The HRB recognises that not efficient environment for all research data can be made research data management open, in order to maintain and sharing. This approach confidentiality and privacy,

32 Health Research Board Annual Report 2019 Enabler C

Enhance organisational performance

2019 Objectives: and document collaboration tool that will enhance our flexible working practices. • Ensure a high-performing working environment built on innovation, adaptability, • Conducted two data protection impact and teamwork. assessments (DPIAs) in relation to the new financial management system and also in • Enable transparent and accountable relation to the HR management system called decision-making based on the best possible Peoplesoft which is under development. information. DPIAs examine personal data to be • Ensure that HRB systems and processes are processed on a system, with the objective robust, flexible, and scalable. of identifying privacy risks in advance of full project implementation. • Enhance recognition of the values of health research and the HRB’s role nationally and • Organised the HRB Grant Holders internationally. Conference to bring together the principal investigators in receipt of HRB grants. The focus of the 2019 conference was to identify Key items delivered in 2019 big health challenges that need a research • Managed a five-year multiannual budget focus, to ensure that the research we fund portfolio totalling €278 million. reflects the needs of the health system, and to open our minds to new ways of thinking • Financial oversight of more than 300 active and working. research awards. • Organised the HRB Ones2Watch conference • Developed a new financial management for early and mid-career HRB-funded system to merge three separate financial researchers. systems into one single application. This consolidation will strengthen financial • Reduced carbon dioxide emissions by 10,531 controls and provide enhanced real-time kg following the installation of 345 LED lights financial reporting and metrics. in the HRB offices. • Awarded the first HRB Impact Award to • Continued to develop a framework for Professor Mary McCarron, Trinity College greater employee resilience, employee Dublin, to acknowledge her work and research engagement, and enhanced performance. in delivering better health and care, creating • Increased awareness and commitment in award-winning housing projects, and driving relation to equality, diversity and inclusion. policy change that is transforming the lives of • Increased available office space by almost people with intellectual disability as they age. 25%. This reflects the growth in the • Upgraded our entire fleet of 97 laptops and organisation and highlights the flexibility of desktops to Windows 10 Enterprise, which our facilities team to accommodate rapid came bundled with a new Office suite and change. Microsoft Teams, a video conferencing Research. Evidence. Action. 33 Case Study 11: Delivering better outcomes and efficiency through innovation and excellence in information and communications technology (ICT)

The HRB’s ICT infrastructure transactions, as well as data and information security, is constantly evolving,’ said facilitating enhanced reporting while for staff it offers superior Martin Morgan, Director of and control over the HRB’s productivity and comes Corporate Operations, HRB. €278 million grant funding bundled with remote working portfolio. tools. All of our key systems ‘We have undertaken an have undergone a Data ambitious programme of ‘Also in 2019, the HRB Protection Impact Assessment work to upgrade many of our continued migrating data from (DPIA), to identify and minimise ICT systems and services. its National Drug Treatment any risks arising. We are aiming to meet, if not Reporting System into the new exceed, the stated objectives shared LINK platform. This ‘The principles of in the Government’s Public brings to almost 128,000 the confidentiality, integrity Service ICT Strategy and to number of patient records on and availability have guided continuously improve the the system, which itself has the systematic and planned HRB’s ICT infrastructure. been developed using privacy development of the HRB’s by design and privacy by IT infrastructure, and we are ‘These are multi-year activities default principles. committed to remaining at the which, when combined, forefront of secure, robust and give our staff the flexibility ‘We also undertook a open digital services’. to work securely from any programme of work to migrate location, be that a laptop in a number of ICT services to an internal meeting room, or the cloud, thereby reducing ‘These are multi-year remote working wherever HRB costs while simultaneously business takes our staff to’. enhancing our business activities which, when continuity and disaster combined, give our Liam Sinnott IT and Facilities recovery capabilities. The staff the flexibility to Manager, added: organisation upgraded its entire fleet of laptop and work securely from ‘In 2019, we undertook a desktop computers and any location, be that a major development project servers to the latest and most laptop in an internal to consolidate three separate secure operating systems. meeting room, or financial management systems into one unified ‘The Windows 10 operating remote working application. When the project system, which we deployed wherever HRB business goes live in 2020, it will on all laptops and desktops, takes our staff to’. bring a range of enhanced brings a multitude of enhanced efficiencies in dealing with business capabilities. On a day-to-day corporate financial corporate level it offers better

34 Health Research Board Annual Report 2019 Case Study 12: Health research – what Ireland needs next

More than 120 delegates CEO of Blue Cottage Consulting. making in health and spoke of the attended the 2019 HRB Grant Dr Rogers has extensive need for health service planners Holders Conference in February experience in applying design to continually move from 2019. thinking approaches to solving observation to implementation complex, or as she described it, to evaluation in order to ensure The two-day event had four main “wicked” healthcare needs. She that outcomes are appropriate objectives. These were: spoke about how she uses design and focused on the end user. thinking in her work, and she • Identify the big health presented a number of examples Professor David Prendergast, a challenges that need a and cases studies of where it has social anthropologist and Head research focus. been successfully used. of the Department of Design • Ensure that the research we Innovation, Maynooth University do reflects the needs of the Two of Ireland’s foremost spoke about his work as Principal health system. innovation and design thinking Investigator at the Technology • Open our minds to new ways experts, Dr Peter Robbins, Research for Independent Living of thinking and working. Assistant Professor, Dublin City Centre and co-founder of the • Shape the direction of the University Business School, Intel Institute for Sustainable next HRB strategy. and Trevor Vaugh, Programme Connected Cities, and the Director, MSc in Design approaches that they took to The conference revolved around Innovation, Maynooth University, designing systems for older a design thinking approach to gave the audience a “deep dive” populations. problem-solving and, in the on design thinking. The audience process, tried to answer the were then challenged to apply Video recordings of all the main rather large and deliberately a design thinking approach to presenters are available on the open-ended question: Health identifying the next big ideas for HRB’s YouTube channel. research – what does Ireland health research in Ireland based need most? on health system needs. Some fantastic ideas emerged from the Design thinking requires exercise and, as a finale, were developing a deep understanding presented to a “Dragons’ Den” of the people for whom you are panel of judges. designing products or services. It challenges assumptions. It Other speakers at the event reframes questions. It rapidly included Laura Magahy, prototypes potential solutions. Executive Director of Sláintecare, And all the while, it keeps the the Government’s 10-year user’s needs to the fore. programme to transform Ireland’s health and social care services. The opening keynote was She emphasised the importance delivered by Dr Juliet L Rogers, of research to inform decision-

Research. Evidence. Action. 35 2

Appendices

36 Health Research Board Annual Report 2019 Appendix A

List of HRB publications in 2019

HRB REPORTS

Daly A and Craig S (2019) Activities of Irish Psychiatric Units and Hospitals 2018. Main Findings. HRB Statistics Series 39. Dublin: Health Research Board.

Daly A and Craig S (2019) Irish Psychiatric Units and Hospitals Census 2019 Main Findings. HRB Statistics Series 40, Dublin: Health Research Board.

Gill C, Lamont A and Moloney T (2019) An evaluation of HRB investment in health research leaders. Dublin: Health Research Board.

Health Research Board (2019) Alcohol Treatment in Ireland 2011–2017. Dublin: Health Research Board.

Health Research Board (2019) Drug Treatment in Ireland 2011–2017. Dublin: Health Research Board.

Health Research Board (2019) Alcohol Treatment in Ireland 2012–2018. Dublin: Health Research Board.

Health Research Board (2019) Drug Treatment in Ireland 2012–2018. Dublin: Health Research Board.

Health Research Board (2019) Drug-related deaths and deaths among drug users in Ireland: 2004– 2016. Figures from the National Drug-related Deaths Index, Dublin: Health Research Board.

Health Research Board (2019) Drug-related deaths and deaths among drug users in Ireland: 2008– 2017. Figures from the National Drug-related Deaths Index, Dublin: Health Research Board.

Irish Focal Point to the EMCDDA (2019) Drugnet Ireland, Issue 68, Winter. Dublin: Health Research Board.

Irish Focal Point to the EMCDDA (2019) Drugnet Ireland, Issue 69, Spring. Dublin: Health Research Board.

Irish Focal Point to the EMCDDA (2019) Drugnet Ireland, Issue 70, Summer. Dublin: Health Research Board.

Irish Focal Point to the EMCDDA (2019) Drugnet Ireland, Issue 71, Autumn. Dublin: Health Research Board.

Irish Focal Point to the EMCDDA (2019) National Report (2018 data) to the EMCDDA by the Reitox National Focal Point, Ireland: new developments, trends. Dublin: Health Research Board.

Hiney M (2019) Outputs, outcomes and emerging impacts: Results from HRB awards completed in 2016/2017. Dublin: Health Research Board.

Ward O and Kennelly H (2019) Review of clinical research infrastructure in Ireland. Dublin: Health Research Board.

EVIDENCE REVIEWS

McCarthy A, Quigley J and Long J (2019) Healthy workplace tools in five countries: An evidence review. Health Research Board, Dublin.

Minyard K, Manteuffel B, Smith CM, Atell BK, Landers G, Schlanger M and Dore E (2019) Treatment services for people with co-occurring substance use and mental health problems. A rapid realist synthesis. Health Research Board, Dublin.

Research. Evidence. Action. 37 Keane M, Moloney T, Lee C, O’Sullivan M and Long J (2019) Vaccine injury redress programmes: An evidence review. Health Research Board, Dublin.

Quigley J, Coyle C, O’Dwyer C, O’Brien D, O’Nolan G, Farragher L and Long J (2019) Regional health organisations. An evidence review. Health Research Board, Dublin.

Johnston BM, May P, McCauley R, McQuillan R, Rabbitte M, Honohan C, Mockler D and Thomas S (2019) Out-of-hours specialist and generalist palliative care service provision: An evidence review. Health Research Board, Dublin.

PEER-REVIEWED JOURNAL ARTICLES, AUTHORED BY HRB STAFF

Cannon A, Nally F, Collins A and Lyons S (2019) Trends in drug and alcohol treatment in prison in Ireland from 2009 to 2014. International Journal of Prisoner Health, 15( 2) 105-113.

Daly A, Craig S and O’Sullivan E (2019) A profile of psychiatric in-patient admissions with no fixed abode (NFA) 2007-2016. Irish Medical Journal, 112 (1).

Doyle A, Lynn E and Lyons S (2019) Profile of fire fatalities in Ireland using coronial data. Fire Safety Journal,110: 102892.

Kelly C, Craig S and McConkey R (2019). Supporting family carers of children and adults with intellectual disability. Who gets priority? Journal of Social Work (online early). DOI: 10.1177/1468017319860312.

Kelly C, McConkey R and Craig S (2019) A case-study of policy change in residential service provision for adult persons with intellectual disability in Ireland. Health and Social Care in the Community (online early), DOI: 10.1111/hsc.12803.

Kelly C, McConkey R and Craig S (2019) Family carers of people with intellectual disabilities in Ireland: Changes over ten years. Journal of Intellectual Disabilities doi.org/10.1177%2F1744629519866313.

McConkey R, Kelly C and Craig S (2019) The prevalence of intellectual disability: a comparison of national census and register records. Research in Development Disabilities 89, 69-75.

McConkey R, Kelly F, Craig S and Keogh F (2019) Changes in the Provision of Day Services in Ireland to Adult Persons with Intellectual Disability. Journal of Policy and Practice in Intellectual Disabilities 16(1)13-20.

O’Dwyer C, Mongan, D, Millar SR et al. (2019) Drinking patterns and the distribution of alcohol- related harms in Ireland: evidence for the prevention paradox. BMC Public Health 19, 1323. https://doi. org/10.1186/s12889-019-7666-4.

Smyth B, Daly A, Elmusharaf K, Clarke M, Craig S and Cullen W (2019) Legislation targeting head shops selling new psychoactive substances and changes in drug related psychiatric admissions: A national database study. Early Intervention in Psychiatry, 2019, 1-8.

Smyth B, O’Farrell A and Daly A (2019) Cannabis use and associated health problems – what’s the harm? Irish Medical Journal, Vol 112; No. 9; P1000.

38 Health Research Board Annual Report 2019 Appendix B

List of HRB awards made in 2019 - to Principal Investigators

PROJECTS AND PROGRAMMES Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Evidence-based guidance Royal College Applied Dr Emma Wallace €207,057 in general practice: of Surgeons Partnership Award exploring general in Ireland practitioner preferences, content prioritisation and dissemination Implementation of Making National Applied Professor Molly Byrne €239,988 Every Contact Count University Partnership Award (MECC): developing a of Ireland collaborative strategy to Galway optimise and scale-up MECC Improving transition from Royal College Applied Dr Jennifer Ryan €204,327 child to adult health of Surgeons Partnership Award services for young people in Ireland with cerebral palsy living in Ireland Implementation of a Frailty University Applied Professor Corina Naughton €244,965 Care Bundle for older College Cork Partnership Award adults in acute care Health system foundations Trinity Applied Dr Sara Burke €278,844 for effective regional College Partnership Award integrated care Dublin organisations (RICOs) – co-producing evidence to inform the design of regional organisations to support integrated care in Ireland Embedding collective University Applied Dr Deirdre O'Donnell €89,766 leadership to foster College Partnership Award collaborative inter- Dublin professional working in the care of older people (Eclectic)

Research. Evidence. Action. 39 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Establish and analyse the NUI Galway/ Cancer Nursing Dr Janice Richmond €10,000 safety and efficacy of an Letterkenny Research Award integrated care model General for the management of Hospital patients receiving oral anti-cancer agents in the community by an advanced nurse practitioner: A pilot study Evaluation of the clinical, University Investigator-Led Professor Patricia Fitzpatrick €367,956 psychological and College Project Award economic effects of the Dublin Cystic Fibrosis Newborn Screening Programme: the Irish Comparative Outcomes Study of CF (ICOS) Part 2 Sláintemedicines – a Royal College Investigator-Led Dr Frank Moriarty €282,871 roadmap to essential of Surgeons Project Award medicines entitlement for in Ireland universal health coverage Study of the impact of University Investigator-Led Dr Keelin O'Donoghue €368,997 dedicated recurrent College Cork Project Award miscarriage clinics in the Republic of Ireland Development of a model Royal College Investigator-Led Dr Helen French €365,886 of care for osteoarthritis in of Surgeons Project Award primary care in Ireland – A in Ireland mixed methods study Transitions of care in University of Investigator-Led Professor Austin Stack €369,210 advanced chronic kidney Limerick Project Award disease Tracking trajectories Royal College Investigator-Led Professor Mary Cannon €357,142 of psychopathology of Surgeons Project Award from infancy to young in Ireland adulthood: an Irish national longitudinal cohort study The Test of Complex University Investigator-Led Dr Pauline Frizelle €368,065 Syntax: final development College Cork Project Award phase, standardisation and diagnostic accuracy with respect to children with developmental language disorder (DLD) and those at risk of language disorder

40 Health Research Board Annual Report 2019 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Bile acids as a host trigger University Investigator-Led Professor Fergal O'Gara €367,992 of chronic infecting College Cork Project Award pathogens in respiratory disease The identification of Royal College Investigator-Led Professor David Cotter €369,583 plasma protein markers of Surgeons Project Award of antipsychotic drug in Ireland treatment response in first-episode psychosis; a proteomic analysis of baseline plasma samples from the OPTiMiSE and PSYSCAN studies Molecular evolution of Royal College Investigator-Led Professor Bryan Hennessy €369,002 metastatic HER2-positive of Surgeons Project Award breast cancer in Ireland Wound infections: biofilms Royal College Investigator-Led Professor Eoghan O'Neill €366,087 and the search for novel of Surgeons Project Award antimicrobial agents in Ireland An investigation of Dublin Dental Investigator-Led Professor David Coleman €368,856 the prevalence and University Project Award molecular epidemiology Hospital of vancomycin-resistant Enterococcus faecium in Irish hospitals using whole- genome sequencing 3D collagen-based Royal College Investigator-Led Dr Caroline Curtin €369,955 scaffolds as gene delivery of Surgeons Project Award platforms for the treatment in Ireland of human breast cancer Analysis of the oral Dublin Dental Investigator-Led Dr Gary Moran €357,585 metagenome for markers University Project Award of malignant transformation Hospital of oral leukoplakia To identify molecular Trinity Investigator-Led Professor Ursula Fearon €365,645 signatures that can predict College Project Award disease onset in ‘at-risk Dublin ACPA+’ individuals and disease progression in RA patients Optimising 40 Hz sensory Trinity Investigator-Led Professor Michael Rowan €369,993 stimulation protocols College Project Award for Alzheimer’s disease Dublin treatment

Research. Evidence. Action. 41 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname A new cell-free DNA liquid Royal College Investigator-Led Professor Annette Byrne €368,715 biopsy assay to predict of Surgeons Project Award bevacizumab outcome in Ireland in metastatic colorectal cancer patients Switching on the light: University Investigator-Led Dr Virginie Gautier €368,772 Reprogramming T cell College Project Award metabolism for novel HIV Dublin Cure interventions FIREFLY: Follow-up of Trinity Investigator-Led Professor Eleanor Molloy €369,890 inflammatory responses College Project Award and multiorgan outcomes Dublin following neonatal brain injury Using guanine to re- National Investigator-Led Professor James O'Gara €369,887 sensitise MRSA to University Project Award methicillin: Is purine of Ireland nucleotide homeostasis Galway the Achilles heel of MRSA antibiotic resistance? Immunometabolic Trinity Investigator-Led Professor Joseph Keane €366,993 manipulation of pulmonary College Project Award immunity – towards TB Dublin host-directed therapy NK cell restore – Can GLP- University Investigator-Led Professor Donal O'Shea €311,376 1 therapy restore tumour College Project Award immunity in severely obese Dublin patients? Prediction of radiation Technological Investigator-Led Professor Fiona Lyng €368,637 toxicity in prostate cancer University Project Award patients using Raman Dublin spectroscopy Stratification of Trinity Joint Programming Professor Peter Bede €1,554,819 presymptomatic College Initiative in amyotrophic lateral Dublin Neurodegenerative sclerosis: the development Diseases of novel imaging biomarkers FAIRVASC – building Trinity EJP Co-fund in Professor Mark Little €2,229,091 registry interoperability to College Rare Diseases inform clinical care Dublin Examining the interplay of Trinity Investigator-Led Professor Maeve Caldwell €369,944 the immune system with College Project Award brain cells in Parkinson’s Dublin disease

42 Health Research Board Annual Report 2019 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Mapping Parkinson’s University Patrick Quinn Dr Suzanne Timmons €212,356 disease needs and services College Cork Awards for in Ireland to inform service Parkinson’s planning Research Collaboration Agreement Royal College Research Dr Lucia Prihodova €298,368 to Establish a Research of Physicians Collaborative in Collaborative for Quality of Ireland Quality and Patient and Patient Safety Phase III Safety Development and University Secondary Data Dr Fergus McCarthy €303,217 validation of a risk College Cork Analysis Project stratification tool for Award assessment of maternal and neonatal morbidity and mortality using data from the National Maternal and Newborn Clinical Management System Evidence for policies to University Secondary Data Professor Patricia Kearney €249,911 prevent chronic conditions College Cork Analysis Project (EPICC) Award Disparities in health University of Secondary Data Professor Austin Stack €249,223 outcomes of chronic Limerick Analysis Project kidney disease between Award men and women in the Irish health system What dictates the extent of University SFI-HRB- Dr Simon Kelly €834,396 evidence accumulation in College Wellcome human decision-making? Dublin Research Partnership Mapping the miRNA atlas Royal College SFI-HRB- Dr Irene Oglesby €336,485 of CF airway epithelial of Surgeons Wellcome cells using patient-derived in Ireland Research gene-edited iPSC Partnership Food-based biomarkers, University US-Ireland R&D Professor Lorraine Brennan €889,104 diet quality and College Partnership Award cardiometabolic health Dublin Study of queuosine salvage Trinity US-Ireland R&D Dr Vincent Kelly €860,712 and function in eukaryotes: College Partnership Award a forgotten micronutrient Dublin

Research. Evidence. Action. 43 CAPACITY BUILDING AND LEADERSHIP ENHANCEMENT Title Host Scheme Lead Lead Lead Total awarded institution Researcher Researcher Researcher title forename surname Computational Letterkenny Cancer Prevention Dr Claire Meaney €23,104 evaluation of Institute of Fellowship morphologic tumour Technology Programme tissue features as Reintegration Grant diagnostic and prognostic predictors of lung cancer Collaborative Doctoral National Collaborative Professor Molly Byrne €1,499,420 Programme in Chronic University Doctoral Award in Disease Prevention of Ireland Patient-focused (CDP-CDP) Galway Research Diabetic foot disease: National Collaborative Professor Timothy O'Brien €1,499,983 from prevention to University Doctoral Award in treatment to improved of Ireland Patient-focused patient outcomes (DFD Galway Research PRIMO) Designing and All Ireland Conference and Dr Mary Rabbitte €4,759 developing technologies Institute of Event Sponsorship for palliative care Hospice and Scheme Palliative Care Fourth Annual HRI University of Conference and Dr Jonathan Salsberg €5,000 Public and Patient Limerick Event Sponsorship Involvement Summer Scheme School Towards a refreshed Care Conference and Ms Zoe Hughes €4,980 national carers strategy Alliance Event Sponsorship – from research to Ireland Scheme policy Translating neurological Royal Conference and Ms Bridget Doyle €5,000 research into clinical College of Event Sponsorship practice Surgeons in Scheme Ireland PPI in vision research Fighting Conference and Dr Laura Brady €5,000 – World Sight Day – Blindness Event Sponsorship Retina 2019 Scheme Launch of the Clinical University Conference and Dr Eileen O'Brien €5,000 Practice Guideline for College Event Sponsorship Nutrition in Pregnancy – Dublin Scheme Translation of Evidence into Practice The Nutrition Society University of Conference and Dr Eibhlís O'Connor €5,000 Annual Irish Section Limerick Event Sponsorship Meeting Scheme

44 Health Research Board Annual Report 2019 CAPACITY BUILDING AND LEADERSHIP ENHANCEMENT Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded Title Host Scheme Lead Lead Lead Total awarded title forename surname institution Researcher Researcher Researcher title forename surname National Conference National Conference and Professor Áine Carroll €5,000 Computational Letterkenny Cancer Prevention Dr Claire Meaney €23,104 on Integrated Care in Rehabilitation Event Sponsorship evaluation of Institute of Fellowship Ireland Hospital Scheme morphologic tumour Technology Programme The First Annual Irish Royal College Conference and Dr Maeve Mullooly €4,354 tissue features as Reintegration Grant Cancer Epidemiology of Surgeons in Event Sponsorship diagnostic and Network Symposium Ireland Scheme prognostic predictors of 2019 lung cancer Standing up for Science Sense about Conference and Ms Síle Lane €2,325 Collaborative Doctoral National Collaborative Professor Molly Byrne €1,499,420 Workshop Science Event Sponsorship Programme in Chronic University Doctoral Award in Scheme Disease Prevention of Ireland Patient-focused Early-career researcher University Conference and Dr Kate O'Neill €4,930 (CDP-CDP) Galway Research event College Cork Event Sponsorship Diabetic foot disease: National Collaborative Professor Timothy O'Brien €1,499,983 Scheme from prevention to University Doctoral Award in Seminar: Supporting University Conference and Dr Attracta Lafferty €5,000 treatment to improved of Ireland Patient-focused Family Carers in the College Dublin Event Sponsorship patient outcomes (DFD Galway Research Workplace Scheme PRIMO) Comparison of Dublin Dental Emerging Dr Brenda McManus €623,331 Designing and All Ireland Conference and Dr Mary Rabbitte €4,759 staphylococcal species University Investigator Award developing technologies Institute of Event Sponsorship from the oro-nasal Hospital for palliative care Hospice and Scheme cavity, periodontal Palliative pockets and foot ulcers Care of patients with type Fourth Annual HRI University of Conference and Dr Jonathan Salsberg €5,000 II diabetes: a potential Public and Patient Limerick Event Sponsorship microbial reservoir Involvement Summer Scheme for diabetic foot ulcer School infection Towards a refreshed Care Conference and Ms Zoe Hughes €4,980 Developing a new Trinity College Emerging Dr Kathy Ruddy €711,946 national carers strategy Alliance Event Sponsorship approach to stroke Dublin Investigator Award – from research to Ireland Scheme rehabilitation for the policy upper limb based on Translating neurological Royal Conference and Ms Bridget Doyle €5,000 TMS neurofeedback research into clinical College of Event Sponsorship Harnessing the power Trinity College Emerging Dr Natalia Munoz-Wolf €799,545 practice Surgeons in Scheme of the gut-lung axis: Dublin Investigator Award Ireland how dietary short-chain PPI in vision research Fighting Conference and Dr Laura Brady €5,000 fatty acids balance – World Sight Day – Blindness Event Sponsorship inflammatory outcomes Retina 2019 Scheme in chronic obstructive pulmonary disease Launch of the Clinical University Conference and Dr Eileen O'Brien €5,000 Practice Guideline for College Event Sponsorship Providing Improved care University Emerging Dr Eve Griffin €736,811 Nutrition in Pregnancy – Dublin Scheme for self-harm: a mixed- College Cork Investigator Award Translation of Evidence methods study of into Practice intervention, economic and implementation The Nutrition Society University of Conference and Dr Eibhlís O'Connor €5,000 outcomes from a Annual Irish Section Limerick Event Sponsorship national clinical Meeting Scheme programme

Research. Evidence. Action. 45 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Engineering RNA- Massachusetts Emerging Dr Piotr Kowalski €799,937 based therapeutics for Institute of Investigator Award treatment of sepsis and Technology sepsis-induced multiple organ dysfunction syndrome SCaRLeT: Sex University of Emerging Dr Linda O'Keeffe €699,546 differences in Bristol Investigator Award Cardiovascular Risk across Life course Transitions Evidence synthesis and Royal College Emerging Dr Barbara Clyne €727,136 translation of findings of Surgeons in Investigator Award for national clinical Ireland guideline development: addressing the needs and preferences of guideline development groups Defining the Trinity College Emerging Dr Sharee Basdeo €699,963 consequences of Dublin Investigator Award innate immune training on protective versus pathogenic T cell responses in patients with tuberculosis The impact of Dublin City Emerging Dr Alex Eustace €799,944 mutations in PI3K/ University Investigator Award AKT pathway gene loci on response to PI3K inhibitors Investigating breast Royal College Emerging Dr Maeve Mullooly €752,127 cancer risk factors of Surgeons in Investigator Award to understand breast Ireland cancer epidemiological outcomes Fulbright-HRB Health University Fulbright-HRB Dr Suja Somanadhan €6,000 Impact Awards 2019 College Dublin Health Impact Award Fulbright-HRB Health Trinity College Fulbright-HRB Professor Brendan Kelly €12,000 Impact Awards 2019 Dublin Health Impact Award Fulbright-HRB Health University Fulbright-HRB Professor Jonathan Hourihane €12,000 Impact Awards 2019 College Cork Health Impact Award

46 Health Research Board Annual Report 2019 Title Host institution Scheme Lead Lead Lead Total Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded Researcher Researcher Researcher awarded title forename surname title forename surname Engineering RNA- Massachusetts Emerging Dr Piotr Kowalski €799,937 Professor Mary Trinity College HRB Impact Award Professor Mary McCarron €50,000 based therapeutics for Institute of Investigator Award McCarron – HRB Impact Dublin treatment of sepsis and Technology Award 2019 sepsis-induced multiple Are recreational waters National Summer Student Mr Raza Abbas Syed €2,400 organ dysfunction a transmission route for University of Scholarship syndrome antibiotic resistance to Ireland Galway SCaRLeT: Sex University of Emerging Dr Linda O'Keeffe €699,546 humans? differences in Bristol Investigator Award Investigating the National Summer Student Mr Colm Kelly €2,400 Cardiovascular Risk composition of acute University of Scholarship across Life course ischaemic stroke blood Ireland Galway Transitions clots Evidence synthesis and Royal College Emerging Dr Barbara Clyne €727,136 Correlating National Summer Student Ms Rachael Power €2,400 translation of findings of Surgeons in Investigator Award blood monocyte University of Scholarship for national clinical Ireland subpopulation analysis Ireland Galway guideline development: with the results of addressing the needs elective coronary and preferences of angiography guideline development Blood pressure control National Summer Student Mr David McCann €2,400 groups in patients identified as University of Scholarship Defining the Trinity College Emerging Dr Sharee Basdeo €699,963 having a previous stroke Ireland Galway consequences of Dublin Investigator Award or transient ischemic innate immune training attack in general on protective versus practice pathogenic T cell Suicide and self-harm National Summer Student Mr Bryan Tanner €2,400 responses in patients in Irish Travellers University of Scholarship with tuberculosis presenting to the Ireland Galway The impact of Dublin City Emerging Dr Alex Eustace €799,944 emergency department: mutations in PI3K/ University Investigator Award clinical outcomes AKT pathway gene loci and engagement with on response to PI3K mental health services inhibitors An implantable National Summer Student Mr John Pereira €2,400 Investigating breast Royal College Emerging Dr Maeve Mullooly €752,127 pressure sensor for the University of Scholarship cancer risk factors of Surgeons in Investigator Award measurement of venous Ireland Galway to understand breast Ireland pressure cancer epidemiological Influence of the tumour National Summer Student Mr Michael Craughwell €2,400 outcomes microenvironment on University of Scholarship Fulbright-HRB Health University Fulbright-HRB Dr Suja Somanadhan €6,000 the pathogenesis of Ireland Galway Impact Awards 2019 College Dublin Health Impact colon cancer Award Bariatric care National Summer Student Mr Robert Hughes €2,400 Fulbright-HRB Health Trinity College Fulbright-HRB Professor Brendan Kelly €12,000 requirements in Ireland: University of Scholarship Impact Awards 2019 Dublin Health Impact developing policy Ireland Galway Award guidance and evaluation Fulbright-HRB Health University Fulbright-HRB Professor Jonathan Hourihane €12,000 (BRIDGE) Study 1 – Impact Awards 2019 College Cork Health Impact Regional bariatric Award referral patterns, 2010- 2019

Research. Evidence. Action. 47 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Use of wearable devices National Summer Student Mr Daniel Coyle €2,400 to monitor motor University of Scholarship disability in multiple Ireland Galway sclerosis – A real world pilot study Can heat shock National Summer Student Ms Muireann Keating €2,400 protein (HSP) inhibitors University of Scholarship induce cell death Ireland Galway in adrenocortical carcinoma (ACC) under induced hyperthermia? Investigating National Summer Student Ms Natalia Otrebska €2,400 immunometabolic University Scholarship compounds in obesity- of Ireland driven inflammation Maynooth Effect of microcracks National Summer Student Mr Raymond Cheong €2,400 formation in the cortical University of Scholarship bone from osteoporotic Ireland Galway and healthy patients on osteoclasts and osteoblasts Carbon monoxide as National Summer Student Mr Jonathan Costello €2,400 a therapy in epithelial University of Scholarship barrier dysfunction of Ireland Galway lung models of sepsis Knowledge of and National Summer Student Ms Kate Finn €2,400 attitude towards HPV University of Scholarship and the HPV vaccine Ireland Galway among inflammatory bowel disease patients Unravelling the chemo- National Summer Student Mr Abdullah AlKhunaizi €2,400 resistant properties University of Scholarship of tumour-associated Ireland Galway stromal cells within the breast tumour microenvironment Acute dialysis in Galway National Summer Student Ms Michaela van der €2,400 University Hospital, a University of Scholarship Jean Walt utilisation audit Ireland Galway The clinical viability National Summer Student Mr Brian Thompson €2,400 of telemedicine in the University of Scholarship management of type 1 Ireland Galway diabetes in the west of Ireland

48 Health Research Board Annual Report 2019 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Non-invasive detection National Summer Student Ms Karin Ishak €2,400 of triple negative University Scholarship breast cancer using Ireland Galway extracellular vesicle (EV) encapsulated microRNAs Evaluation of microwave National Summer Student Mr Daniel Kelly €2,400 imaging prototype for University of Scholarship osteoporosis monitoring Ireland Galway Assisting with the Waterford Summer Student Ms Nicola Kelleher €2,400 implementation and Institute of Scholarship evaluation of the Irish Technology Men's Sheds Association "Sheds for Life" project Injuries in non- Dublin City Summer Student Ms ElÁine McDermott €2,400 horseracing-related University Scholarship activities: Is it time to focus on injury prevention outside of race day? Comparative migration National Summer Student Mr Ahmed Eltayeb €2,400 and angiogenic University of Scholarship properties of Ireland Galway mesenchymal stem cells derived from bone marrow and umbilical cord Trends and prevalence Dublin City Summer Student Ms LorrÁine Tham €2,400 of gestational diabetes University Scholarship mellitus among women giving birth in Irish hospitals from 2008 to 2016: Risk factors and outcomes Elucidation of the University Summer Student Ms Harsha Daswani €2,400 neural networks College Cork Scholarship underlying sex differences in vulnerability to developing depression The role of diabetes- National Summer Student Ms Jia Leng Lim €2,400 related distress in the University of Scholarship association between Ireland Galway body mass index and physical activity in type 2 diabetes mellitus: a mediator-moderator analysis

Research. Evidence. Action. 49 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname The multi-finger force Trinity College Summer Student Mr Simon Bergin €2,400 deficit: can it classify Dublin Scholarship motor neurone disease subtypes? My health starts with Trinity College Summer Student Ms Niamh Donohoe €2,100 me, the 'how to' of Dublin Scholarship research with people with intellectual disability: building a toolkit to promote the voice of people with intellectual disability in health research Exploring a novel biofilm National Summer Student Ms Emer Brennan €2,400 control mechanism University of Scholarship in a cerebrospinal Ireland Galway fluid isolate of Staphylococcus epidermidis responsible for a device-related infection Functional loss among Trinity College Summer Student Ms Rachel Kirwan €2,400 older adults with Dublin Scholarship intellectual disability and dementia: findings from the Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing (IDS- TILDA) Genomic profiling Trinity College Summer Student Mr Ciaran O'Connor €2,400 of intestinal immune Dublin Scholarship activity using T cell receptor sequencing Investigate the role University Summer Student Ms Niamh Mahon €2,400 of epigenetics in College Dublin Scholarship pseudoexfoliation glaucoma Prescribing patterns Trinity College Summer Student Ms Anne- Doherty €2,400 in a long-term care Dublin Scholarship Marie psychiatric facility in Ireland: a descriptive study Measuring parenting University Summer Student Ms Hannah Bristow €2,400 stress, quality of life and College Dublin Scholarship resilience related to caring for a child with mucopolysaccharidosis (MPS)

50 Health Research Board Annual Report 2019 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Effect of edaravone, an National Summer Student Ms Claire Coleman €2,400 approved treatment for University of Scholarship motor neurone disease, Ireland Galway on proliferation of human neuronal stem cells Development of a Royal College Summer Student Ms Aleece Warner €2,400 pre-clinical test to of Surgeons in Scholarship detect dysfunctional Ireland haemostasis The association Royal College Summer Student Mr Ross King €2,400 between early of Surgeons in Scholarship childhood chronic Ireland illness and psychological difficulties in adolescence Investigation of the National Summer Student Mr Colm O'Sullivan €2,400 effect of asthma University Scholarship patient serum on MSC of Ireland cytoprotective function Maynooth in vitro Testing novel SRF University Summer Student Ms Kuan Yee Ng €2,400 inhibitors in breast and College Dublin Scholarship prostate cancer Language development University Summer Student Ms Maeve O'Sullivan €2,400 in twins: a comparison College Cork Scholarship with closely and widely spaced siblings Validation of blood- Royal College Summer Student Mr Kehinde Babatunde €2,400 based samples from the of Surgeons in Scholarship OPTiMiSE (OPtimisation Ireland of Treatment and Management of Schizophrenia in Europe) study Antibiotics adherence Royal College Summer Student Ms Evelyn Flynn €2,400 monitoring and use of of Surgeons in Scholarship technologies in children Ireland with cystic fibrosis: a systematic review Examining the role Royal College Summer Student Mr Giovanni Andrei Saw €2,400 of long non-coding of Surgeons in Scholarship Ye Jeune RNAs in regulating Ireland microcalcification in ductal carcinoma In situ

Research. Evidence. Action. 51 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname The role of activated Trinity College Summer Student Ms Adina Mac Mahon €2,400 astrocytes in Dublin Scholarship Copas Alzheimer's disease The characteristics and National Summer Student Ms Sinead Burke €2,400 demographics of the University of Scholarship Irish Enroll-HD cohort: Ireland Galway an interrogation of the database Assessing the effect National Summer Student Ms Sarah Giffney €2,400 of the acidic tumour University Scholarship microenvironment on T of Ireland cell function Maynooth Eudemonic wellbeing in Trinity College Summer Student Mr Jordan Collins €2,400 older adults Dublin Scholarship Investigating the effect Trinity College Summer Student Ms Michele O'Sullivan €2,400 of myeloperoxidase Dublin Scholarship inhibition in monocytes stimulated with anti- myeloperoxidase antibodies on IL- 1β production and glycolysis Determining the Trinity College Summer Student Mr Leon Seow €1,800 effect of exercise Dublin Scholarship in modulating the inflammatory blood profile of patients with metastatic prostate cancer A profiling study of Trinity College Summer Student Mr Robert Keegan €2,400 physical function Dublin Scholarship and performance in a population of supplemental oxygen and/or long-term non-invasive ventilation users attending a respiratory outpatient service Novel strategies to Trinity College Summer Student Ms Cliodhna Daly €2,400 promote cartilage Dublin Scholarship repair in the OA joint A search for variants Trinity College Summer Student Mr Kejan Lim €2,400 associated with autism Dublin Scholarship spectrum disorder in a multiplex family

52 Health Research Board Annual Report 2019 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Predictive value of Trinity College Summer Student Ms Alison Bell €2,100 a lung biopsy, in the Dublin Scholarship paediatric Down Syndrome population, for determining the utility for cardiac surgical repair Investigating Royal College Summer Student Ms Caitlyn Loo €2,400 macrophage activation of Surgeons in Scholarship Joy Yang in response to damage- Ireland Xin associated molecular patterns in multiple sclerosis Utility of the Royal College Summer Student Ms Louise McDonagh €2,400 STarTBack Tool for of Surgeons in Scholarship risk stratification in Ireland people with back pain presenting to a physiotherapy service in the emergency department Assessment of novel Royal College Summer Student Mr Jack Bell €2,400 gene delivery vectors of Surgeons in Scholarship with collagen-based Ireland scaffolds for the abrogation of human breast cancer cells Establishing P2X7 Royal College Summer Student Mr Razi Alalqam €2,400 targeting as a novel of Surgeons in Scholarship treatment strategy for Ireland seizures in nenoates The impact of social Trinity College Summer Student Ms Ruth Aherne €2,400 prescribing as a method Dublin Scholarship to increase engagement of older adults in community activities A survey of clinician Trinity College Summer Student Ms Sofia O'Byrne €2,400 views of issues relevant Dublin Scholarship to the implementation of the nationally agreed Irish Early Warning System (I-MEWS) First-episode psychosis University Summer Student Ms Emily Moloney €2,400 (FEP) and substance College Cork Scholarship use; impact of Early Intervention Service (EIS)

Research. Evidence. Action. 53 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Modulating the Trinity College Summer Student Ms Grainne Cremin €1,800 microbiota-gut-brain Dublin Scholarship axis with putative psychobiotics – effect on stress and anxiety measures in a human population Developing epiCaPture: University Summer Student Ms Laoise McArdle €2,400 a non-invasive urine College Dublin Scholarship test for early detection of aggressive prostate cancer Can novel cancer driver Royal College Summer Student Ms Xiangmei Cui €2,400 genes be identified by of Surgeons in Scholarship analysing mutations in Ireland cancer genomes? Fidelity of stress- University Summer Student Mr Gregory Gorman €2,400 reduction interventions College Cork Scholarship in the first 1000 days What wellbeing National Summer Student Ms Marie Simpson €2,400 supports do University of Scholarship undergraduate students Ireland Galway prioritise: analysis of qualitative survey responses Obesity and Trinity College Summer Student Ms Tammy Maher €2,400 oesopahgeal cancer: Dublin Scholarship role of the fat tissue in controlling energy and inflammation Validation of Trinity College Summer Student Mr Sean O'Brien €2,400 radiosensitising Dublin Scholarship microRNAs for oesophageal cancer The relationship University Summer Student Ms Aileen O'Mahony €1,800 between maternal College Cork Scholarship Bernadette attachment and maternal postnatal depression and the effects of infant massage on maternal postnatal depression scores and developmental progress at 4 months

54 Health Research Board Annual Report 2019 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Effect of load variation University of Summer Student Ms Anna Healy €2,400 on shoulder function, Limerick Scholarship pain and tendon health Factors that influence Trinity College Summer Student Mr Naveen Kurian €2,400 men to study speech Dublin Scholarship and language therapy Infection prevention Trinity College Summer Student Ms Komal Virk €2,400 and control and Dublin Scholarship sustainable dentistry: a comparative life cycle analysis of reusable and single-use dental personal protective clothing (gowns) Farmers Have University Summer Student Ms Grace Richardson €2,400 Hearts': assessing College Cork Scholarship the effectiveness of a behaviour change programme designed to improve the health status of Irish farmers A bioengineered in Royal College Summer Student Ms Sarah Cullen €2,400 vitro disease model of Surgeons in Scholarship of pancreatic ductal Ireland adenocarcinoma integrating cancer cell and fibroblast populations with a tuneable 3D tumour microenvironment to review metastatic progression Determination of the Royal College Summer Student Mr JAKE McDonnell €2,400 optimal management of Surgeons in Scholarship strategy for unilateral Ireland cervical facet fractures Primary care University Summer Student Ms Mary Ellen McMahon €2,400 interventions to prevent College Dublin Scholarship hospital readmissions among older adults: a scoping review in general practice

Research. Evidence. Action. 55 Title Host institution Scheme Lead Lead Lead Total Researcher Researcher Researcher awarded title forename surname Can we make restraint a Waterford Summer Student Ms Malgorzata Ochocka €2,400 last resort intervention Institute of Scholarship in nursing homes in Technology Ireland? An exploration of the knowledge, experience and attitudes of nursing home staff regarding the use of de-escalation Interrogating steroid National Summer Student Ms Debra Gahan €2,400 non-responsiveness University Scholarship in the Irish paediatric of Ireland eosinophilic Maynooth oesophagitis population Side effects and Technological Summer Student Ms Jennifer O'Neill €2,400 mechanisms of action University Scholarship of 0.02% atropine on Dublin visual function and ocular physiology Contraction frequency Dublin City Summer Student Mr Cian Sutcliffe €2,400 as a modulator of University Scholarship metabolism: the role of different muscle fibre type in substrate utilisation Non-viral gene therapy Royal College Summer Student Mr Armaan Handa €2,400 approaches for of Surgeons in Scholarship osteoarthritis Ireland A study of the clinical Trinity College Summer Student Mr Richard Farnan €2,400 characteristics of Dublin Scholarship those with resistant hypertension and young adults with hypertension referred to a specialist hypertension clinic Assessment of Dublin City Summer Student Mr Cian Monaghan €2,400 functional capacity, University Scholarship pulmonary function and quality of life in individuals with pulmonary hypertension Screening and cervical University Summer Student Mr Daíre O'Gorman €2,400 cancer: identification College Cork Scholarship of interval cancers and analysis of socio- demographic and clinical characteristics by screening status

56 Health Research Board Annual Report 2019 INFRASTRUCTURE AND NETWORKS Title Host Scheme Lead Lead Lead Total institution Researcher Researcher Researcher Awarded title forename surname Transition funding for Irish Clinical Cancer Trials Ireland Professor Linda Coate €3,561,620 CTI for 2020 to allow Oncology time for design and Research development of a new Group funding model Limited Dementia and Trinity Dementia and Professor Brian Lawlor €180,490 Neurodegeneration College Neurodegeneration Network Ireland Dublin Network Ireland Development of a National Proof of concept Dr Simon Wong €370,000 proof of concept University technical model for data environment for of Ireland ‘DASSL’ health and related Galway research under the DASSL model

Research. Evidence. Action. 57 Appendix C

HRB Co-funded awards

Scheme Cofunding partner Co-funding Total award HRB share allocation

Applied Partnership Health Service Executive €39,994 €239,991 €199,997 Awards

Applied Partnership HSE South SouthWest Hospital €50,000 €244,965 €194,965 Awards Group

Applied Partnership Irish College of General €36,303 €217,815 €181,512 Awards Practitioners

Applied Partnership National Clinical Progamme for €15,000 €89,940 €74,940 Awards Older People (NCPOP)

Applied Partnership Sláintecare Implementation Office €79,997 €278,844 €198,847 Awards and HSE

Applied Partnership The Central Remedial Clinic €35,200 €204,328 €169,128 Awards

Cancer Nursing Award Irish Cancer Society, NCCP/ €148,324 €158,324 €10,000 ONMSD

Cancer Prevention Irish Cancer Society €11,552 €23,104 €11,552 Fellowship Programme Reintegration Grant

EJP Co-fund in Rare European partner agencies in €1,900,731 €2,229,091 €328,360 Diseases France, Sweden, Poland, Czech Republic, the UK, and the Netherlands

Joint Programming European partner agencies in €1,184,966 €1,554,819 €369,853 Initiative in France, the UK, and Canada Neurodegenerative Diseases

Patrick Quinn Award Parkinsons Association (Patrick €582,332 €582,332 €0 Quinn Legacy)

Research Collaborative in HSE National Quality €255,954 €298,368 €42,414 Quality and Patient Safety Improvement Team

Research Collaborative in National Medication Safety €129,701 €259,403 €129,702 Quality and Patient Safety Programme, HSE

58 Health Research Board Annual Report 2019 HRB Co-funded awards

Scheme Cofunding partner Co-funding Total award HRB share allocation

Research Collaborative in Quality and Patient Safety, Cork €139,337 €278,675 €139,338 Quality and Patient Safety University Hospital

Research Collaborative in Secondary Data Analysis Projects €111,410 €610,627 €499,217 Quality and Patient Safety

Research Collaborative in Department of Sociology, TCD €57,410 €307,410 €250,000 Quality and Patient Safety

Research Collaborative in National Perinatal Epidemiology €54,000 €303,218 €249,218 Quality and Patient Safety Centre

SFI-HRB-Wellcome Wellcome Trust UK and Science €878,160 €1,170,881 €292,720 Research Partnership Foundation Ireland

US-Ireland R&D Science Foundation Ireland €874,907 €1,749,815 €874,907 Partnership Award

Grand total €6,473,869 €10,191,322 €3,717,453

Research. Evidence. Action. 59 Corporate Governance and Financial Statements

The Corporate Governance and Financial Statements information will be published in a Part 2 to this document upon receipt of the audited financial statements from the Office of the Comptroller and Auditor General.

60 Health Research Board Annual Report 2019 Published by:

Health Research Board, Dublin

Copies of this report can be obtained from: Health Research Board Grattan House 67-72 Lower Mount Street Dublin 2 D02 H638 Ireland t 353 1 234 5000 f 353 1 661 2335 e [email protected] w www.hrb.ie t Ireland D02 H638 Dublin 2 67-72 Lower MountStreet Grattan House Health Research Board Éire D02 H638 Baile ÁthaCliath 2 67-72 SráidanMhótaÍochtarach Teach Grattan An BordTaighde Sláinte w e

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5000 Annual Report 2019 Action. Evidence. Research.