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Health Research Board Annual Report 2019 €38.4M to Support 164 Awards Across 18 Host Institutions and Research-Performing Organisations

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Health Research Board Annual Report 2019 €38.4M to Support 164 Awards Across 18 Host Institutions and Research-Performing Organisations Annual Report An Bord Taighde Sláinte Teach Grattan 67-72 Sráid an Mhóta Íochtarach Baile Átha Cliath 2 D02 H638 Éire Health Research Board Grattan House 67-72 Lower Mount Street Dublin 2 D02 H638 Ireland t +353 1 234 5000 Research. e [email protected] w www.hrb.ie Evidence. @hrbireland Action. 2019 Published by: Health Research Board, Dublin © Health Research Board 2020 ISSN: 0791 220X Copies of this report can be obtained from: Health Research Board Grattan House 67-72 Lower Mount Street Dublin 2 D02 H638 Ireland t 353 1 234 5000 f 353 1 661 2335 e [email protected] w www.hrb.ie Contents Chair and Chief Executive’s report 4 Snapshot of HRB activities during 2019 7 Key deliverables in line with HRB strategy 2016–2020 13 Appendix A – HRB publications in 2019 37 Appendix B – HRB awards made in 2019 – to Principal Investigators 39 Appendix C – HRB co-funded awards 58 Research. Evidence. Action. 1 Outcomes and Impact in 2019 128,000 8,142 live records patients contributing to on LINK clinical studies at the three HRB Clinical Research Facilities (HRB-CRFs), including 916 patients participating in active active1,375 users on LINK clinical trials online data system 179 4,643 requests for data cancer patients contributing to 166 Cancer Trials Ireland from the HRB NHIS received and studies; 1,775 of these cancer responded to patients are participating in 135 active clinical trials €38.4m awarded (including €6.5m co-funding) 164 5 awards across 12 evidence reviews host institutions and produced for the research-performing Department of Health organisations peer-reviewed journal articles 11 published using HRB National Health Information Systems (NHIS) data 249 clinical studies underway at the three HRB Clinical Research Facilities (CRFs); 116 of these clinical studies are €16.9m active trials leveraged from Horizon 2020 for 19 health-related projects and a further €0.5m leveraged from the Public Health Programme 16 HRB reports published 172 Research.research Evidence. jobs Action. 3 supported Chair and Chief Executive’s Report Prof Jane Grimson Dr Darrin Morrissey Chairperson Chief Executive The HRB continued to make strong Health research delivery and impact progress during 2019 to deliver the Key initiatives delivered during 2019 included: HRB Strategic Plan (2016–2020). The • Funding a selection of new and existing introduction of new award schemes and awards worth more than €38 million, which career paths for health researchers is are aligned to our strategic priorities; some having a positive impact for researchers, examples include: supporting development of health research > Collaborative Doctoral Awards to support infrastructure and helping to build doctoral training programmes for future capacity in order to involve citizens across health researchers in a variety of specialties the health research lifecycle. The HRB’s > Emerging Investigator Awards to boost reputation for the provision of quality data the development of new and talented and evidence continues to grow, and this is researchers and guide them to research reflected in national policies and requests independence from other organisations to re-use the data > Secondary Data Analysis Projects awards we collect. to develop research projects that answer policy and/or practice-relevant The HRB’s influence, and the impact of the questions using secondary data work the organisation is doing, is evident both > Proof of Concept of a data environment nationally and across Europe. In Ireland, we for health and related research using the continue to lead the way in key areas such data, access, storage, sharing and linkage as open research, and public and patient (DASSL) model. involvement in research. In Europe, we hold leading positions on advisory groups in areas • Delivering five evidence reviews and such as drugs, research integrity, biobanking, completing five evidence briefs for the and personalised medicine, which gives an Department of Health, encompassing areas important voice to Irish researchers in a such as vaccine injury redress programmes European context. and investigating the impact of introducing a regionalised healthcare system. Through this report, we illustrate some of the • Achieving PubMed indexing for HRB Open impacts we have made and some of the new Research, Ireland’s first open access directions we have taken during 2019. This publishing platform. was achieved through the commitment and dedication of staff and the skilled oversight • Supporting more than twenty conferences of the HRB Board. We extend our thanks and and events through our sponsorship call. appreciation to both our staff and the Board for • Awarding the first HRB Impact Award the significant progress made during the year. to Professor Mary McCarron, TCD, to 4 Health Research Board Annual Report 2019 €38.4m to support 164 awards across 18 host institutions and research-performing organisations acknowledge her work and research that • Enabled more than 4,500 cancer patients is transforming the lives of people with to enrol in 166 Cancer Trials Ireland clinical intellectual disability as they age. trials and studies. • Publishing three evaluation reports on More detail on these and other examples and case clinical research infrastructure, research studies which demonstrate what was achieved leaders, and outputs and outcomes from during the year are included throughout this report. HRB awards completed in 2016 and 2017. • Establishing the Secretariat support office Health research collaboration for the national Health Research Consent Working together with other funders and Declaration Committee. research-delivery bodies, we have had some • Developing a new financial management system significant achievements during the year. This merging three separate financial systems into has involved: one single application in order to consolidate • Using data from our National Health financial controls and provide enhanced real- Information Systems (NHIS) to help the time financial reporting and metrics. Road Safety Authority (RSA), National Office of Suicide Prevention, and • Achieving gender balance, both in HRB peer the National Directorate for Fire and review panels and in funding awards. Emergency Management to understand the • Hosting an interactive conference for HRB circumstances of deaths. grant holders, centred around the concept • Researching co-funding initiatives both of ‘design thinking’, in order to encourage on the island of Ireland – with Science lateral thinking and approaches to health Foundation Ireland, the Irish Research research ideas. Council, the Health and Social Care Research Through its funding mechanisms, the HRB: and Development Division of the Public • Invested €38.4 million in supporting 164 Health Agency in Northern Ireland and health research awards across 18 host institutions research charities – and internationally – with and research-performing organisations. the Wellcome Trust Fulbright, the National Institutes of Health in the United States (US), • Supported 172 research jobs. and EU joint programming initiatives. • Helped Irish researchers leverage around €17 • Hosting a meeting of the international Funders million from Horizon 2020. Forum on Ensuring Value in Research. • Supported the recruitment of more than • Co-hosting a workshop on dementia research 8,000 patients in 249 clinical trials and with the HSE National Dementia Office. studies underway at HRB Clinical Research Facilities (CRFs). • Providing data on the drug treatment situation in Ireland, in order to inform Research. Evidence. Action. 5 European monitoring and trends, in This started with a comprehensive consultation collaboration with the European Monitoring process which involved meetings and workshops Centre on Drugs and Drug Addiction with multiple stakeholder groups as well as an online (EMCDDA). survey that generated more than 220 responses. • Working with the Department of Health to The outcomes from the consultation process deliver the second National Drugs Forum, contributed to an international expert which took place at the Aviva Stadium, advisory panel who convened in October 2019. Dublin, in November. Their role was to assess the HRB’s strategic performance to date, draw together key New directions emerging themes from the broad stakeholder The HRB is actively working with the engagement process, and to offer their Department of Health to deliver upon and international perspective on future directions implement new legislation and regulation in for health research in Ireland. relation to health research. To this end, two new offices will have been established in the We would like to acknowledge the valuable HRB over the period 2019/2020. insights and recommendations we received throughout the consultation process Using The HRB Secretariat for the Health Research input from the various stakeholder groups Consent Declaration Committee (HRCDC) and the international panel, the HRB Board became fully operational in January 2019. It is currently working on developing new has a strategic role in supporting the Health strategic priorities and key actions for the new Research Regulations 2018. A total of 86 corporate strategy, which will be in place from applications for consent declarations were in early 2021. We will publish the new strategy submitted to the HRCDC in 2019. The HRCDC by the end of 2020. convened nine times and made 23 decisions. The HRB also worked with the Department of Health to establish a National Office for Research Ethics Committees which will also be supported by a team based
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