Posters 1025 enteral feeding of preterm . Objective of this SCREENING AND MANAGEMENT OF research was to determine incidence of necrotizing NEONATAL BY TRANSCUTANEOUS enterocolitis (NEC) in structure of morbidity and relative risk (RR) of acquiring NEC in preterm infants fed with fortified human milk (FHM) and preterm E. Tiberi, L. Giordano, C. Romagnoli, E. Zecca formula (PF) respectively. Department of , Division of , Policlinico Gemelli UCSC, Rome, Italy Methods: Total of 100 preterm infants of gestational age less than 34 weeks were included in this Objective: The aim of this study was to assess the prospective analysis. Subjects were divided in two validity of our previously developed skin bilirubin groups: group I (n=50) fed with FHM (FM 85 Nestle) nomogram in predicting severe hyperbilirubinemia and group II (n=50) fed with PF (preNAN Nestle) (> 17 mg/dl) in healthy term and late preterm in case where lactation wasn´t established, for 4 newborns. weeks. NEC was diagnosed if presence of intestinal pneumatosis on X-ray was verified (Bell´s stage II Methods: This multicenter study was conducted and III). from February 2009 to December 2009 in the well-baby nurseries of five centres of Rome. The Results: Initially, examined groups did not differ predictive ability of the nomogram for transcutaneous considering the gestational age, Apgar score and bilirubin (TCB) values in the first 96 hours of life antropometric parameters at birth. Subjects fed with was prospectively assessed in 2167 neonates FHM reached full enteral feeding earlier compared with gestational age ≥35 weeks. Skin bilirubin was to PF fed group (p< 0,05). Incidence of NEC in FHM measured with the Bilichek and serum bilirubin was fed group was 2%, and in PF fed group 6% (p>0,05). contemporary assayed by a spectrophotometric In FHM fed group RR=0,33, 95% CI (0,36-3,097), method. 1074 neonates had more than one which means that risk of acquiring NEC is 33% less measurements giving a total of 3241 values. compared to risk in PF fed group.

Results: The mean TSB values was 8,3 ± 3 mg/dl, Conclusion: There is no statistically significant while the mean TCB values was 9,5 ± 3,3 mg/dl. A difference between these two groups in incidence sensitivity of 96,4% and a negative predictive value of NEC, but RR indicates a smaller risk of NEC in (NPV) of 99.9% were obtained with a single bilirubin FHM fed group determination applying the 75° percentile of our nomogram. Two consecutive TCB determinations identified all infants reaching TSB values > 17 mg/ 1027 dl (100 % of sensitivity and 100% of NPV). PARATHYROID HORMONE RELATED PROTEIN (PTHRP) IN PRETERM HUMAN MILK Conclusion: The 75° percentile of the skin bilirubin 1,2 1,2 1 1 nomogram for the European population in the first A. Ben Tov , R. Lubetzky , S. Ben Or , T. Taxir , 1 2,3 2,3 96 hours of life is able to predict all neonates at risk G. Zeidenberg , S. Dollberg , D. Mandel , 2,3 of severe hyperbilirubinemia. It is a reliable guide I. Berger for intervention and follow-up, and allows a safe 1Pediatric, Sourasky Medical Center, 2Sackler discharge from the hospital, also reducing a large Faculty of Medicine, Tel-Aviv University, number of blood samples. 3Neonatology, Sourasky Medical Center, Tel Aviv, Israel 1026 Background: Parathyroid hormone-related protein NECROTIZING ENTEROCOLITIS IN PRETERM (PTHrP) has the ability to activate parathyroid INFANTS ON DIFFERENT FEEDING PROTOCOL hormone receptors and cause hypercalcaemia. In a previous study we demonstrated high levels V. Marinkovic, N. Bozinovic-Prekajski, of PTHrP in both term and preterm human milk V. Hajdarpasic (HM) ( Medicine, 2009). PTHrP Institute for Neonatology, Belgrade, Serbia intestinal absorption and its influence upon calcium homeostasis of the preterm (PTI) has not Background and aims: Feeding with human milk been studied yet. (HM) is in correlation with many useful effects and represents key component in strategy of

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