Datasheet M00785 Anti-MAD2L1/Mad2 Monoclonal Antibody

Product datasheet Anti-MAD2L1/Mad2 Monoclonal Antibody Catalog Number: M00785 BOSTER BIOLOGICAL TECHNOLOGY Special NO.1, International Enterprise Center, 2nd Guanshan Road, Wuhan, China

Web: www.boster.com.cn Phone: +86 27 67845390 Fax: +86 27 67845390 Email: [email protected]

Basic Information Product Name Anti-MAD2L1/Mad2 Monoclonal Antibody Gene Name MAD2L1 Source Mouse Species Reactivity human Tested Application IP, WB Contents Immunogen Purification Observed MW Dilution Ratios Western Blot, 1:200 - 1:2, 000, human Direct ELISA, 1:5, 000 - 1:20, 000, human ImmunoPrecipitation: 1:100, human

Storage 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing

Background Information Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene. This gene belongs to the MAD2 family. It is mapped to 4q27. MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The protein has two highly different native conformations, an inactive open conformation that cannot bind CDC20 and that predominates in cytosolic monomers, and an active closed conformation. It is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment.

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1 / 2 Product datasheet Anti-MAD2L1/Mad2 Monoclonal Antibody Catalog Number: M00785 BOSTER BIOLOGICAL TECHNOLOGY Special NO.1, International Enterprise Center, 2nd Guanshan Road, Wuhan, China

Web: www.boster.com.cn Phone: +86 27 67845390 Fax: +86 27 67845390 Email: [email protected]

Selected Validation Data

Western blot analysis of MAD2L1 expression in HeLa whole cell lysate. MAD2L1 at 24KD was detected using mouse anti-MAD2L1 monoclonal antibody (Catalog # M00785) at 1:200. IRDye?800 fluorescence image was captured using the Odyssey? Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI- COR, Inc. Other detection systems will yield similar results.