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Product Cas Therapeutic Use Status Status

PRODUCT CAS THERAPEUTIC USE STATUS Azithromycin Bitterless API 83905-01-05 Antibiotic EDMF Bepotastine API 190786-44-8 Antihistaminic Pipeline Brimonidine API 70359-46-5 Antiglaucoma Pipeline Brinzolamide API 138890-62-7 Antiglaucoma EDMF, JDMF L - Carnosine API 305-84-0 Nutraceutical Development Diacerein API 13739-02-1 Antiarthritic EDMF Dorzolamide API 130693-82-2 Antiglaucoma EDMF Etofenamate API 30544-47-9 Anti-inflammatory EDMF, CEP Febuxostat API 144060-53-7 Antihyperuricemia EDMF Frovatriptan API 158930-17-7 Antimigraine Development Lifitegrast API 1025967-78-5 Dry eye ( DED ) Agent Pipeline Nimodipine API 66085-59-4 Vasodilator cerebral EDMF Nitazoxanide API 55981-09-4 Antihelmintic EDMF Prasugrel API 150322-43-3 Cardiovascular thrombosis Development Ripasudil API 887375-67-9 Antiglaucoma Pipeline Silodosin API 160970-54-7 Prostatic hyperplasia Development PRODUCT CAS THERAPEUTIC USE STATUS Bimatoprost HPAPI 155206-00-1 Antiglaucoma DMF Carboprost HPAPI 58551-69-2 Oxytocic Development Fingolimod HPAPI 162359-55-9 Multiple Sclerosis Development Latanoprost HPAPI 130209-82-4 Antiglaucoma EDMF Limaprost HPAPI 74397-12-9 Vasodilator Pipeline Travoprost HPAPI 157283-68-6 Antiglaucoma DMF Tafluprost HPAPI 209860-87-7 Antiglaucoma Pipeline Lubiprostone HPAPI 136790-76-6 IBS Agent Pipeline PRODUCT CAS THERAPEUTIC USE REGULATORY DATA Azithromycin Bitterless API 83905-01-05 Antibiotic Technical package Brinzolamide USP API 138890-62-7 Antiglaucoma EDMF L - Carnosine API 305-84-0 Nutraceutical Diacerein API 13739-02-1 Antiarthritic EDMF Dorzolamide Hydrochloride USP/EP API 130693-82-2 Antiglaucoma EDMF Duloxetine Hydrochloride API 136434-34-9 Antidepressive Samples available Etofenamate EP API 30544-47-9 Anti-inflammatory EDMF, CEP Febuxostat API 144060-53-7 Antihyperuricemia Samples available Fingolimod API 162359-55-9 Multiple Sclerosis Development Frovatriptan API 158930-17-7 Antimigraine Final R&D Nimodipine USP/EP API 66085-59-4 Vasodilator cerebral EDMF Nitazoxanide API 55981-09-4 Antihelmintic EDMF Pirisudanol API 53659-00-0 Antidepressant EDMF Prasugrel API 150322-43-3 Cardiovascular thrombosis Development Silodosin API 160970-54-7 Prostatic hyperplasia Development PRODUCT CAS THERAPEUTIC USE REGULATORY DATA Alprostadil USP HPAPI 745-65-3 Vasodilator Pipeline Bimatoprost HPAPI 155206-00-1 Antiglaucoma Final R&D Carboprost USP Tromethamine salt HPAPI 58551-69-2 Oxytocic R&D Dinoprost HPAPI 38562-01-5 Oxytocic R&D Latanoprost USP HPAPI 130209-82-4 Antiglaucoma EDMF Misoprostol USP HPAPI 59122-46-2 AINS Pipeline Travoprost USP HPAPI 157283-68-6 Antiglaucoma Final R&D Treprostinil HPAPI 81846-19-7 Vasodilator Pipeline.

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Eyelash Growth Induced by Topical Prostaglandin Analogues, Bimatoprost, Tafluprost, Travoprost, and Latanoprost in Rabbits
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS ORIGINAL ARTICLE Volume 00, Number 0, 2013 ª Mary Ann Liebert, Inc. DOI: 10.1089/jop.2013.0075 Eyelash Growth Induced by Topical Prostaglandin Analogues, Bimatoprost, Tafluprost, Travoprost, and Latanoprost in Rabbits Ama´lia Turner Giannico,1 Leandro Lima,1 Heloisa Helena Abil Russ,2 and Fabiano Montiani-Ferreira1 Abstract Purpose: Prostaglandin analogues (PGA) are ocular hypotensive agents used for the treatment of glaucoma. Hypertrichosis of the eyelashes has been reported in humans as a side effect. Eyelash growth was investigated with clinical trials in people using bimatoprost. Scattered reports of eyelash growth during the treatment of glaucoma with other PGA are also found in the literature. We investigated the effect of 4 different topical PGA on eyelash length. Methods: Forty New Zealand white rabbits were divided into 4 groups and received daily topical application of bimatoprost, tafluprost, travoprost, and latanoprost in the left eye for 4 weeks. The right eye received no treatment. Eyelash length was measured in both eyes before and after treatment using a stainless steel digital caliper. Results: Bimatoprost and tafluprost groups had significant increases in eyelash length. We did not observe significant eyelash growth in rabbits receiving travoprost and latanoprost after 1 month of treatment. Conclusions: Today, only bimatoprost is approved for growing eyelashes, and our research shows that ta- fluprost could be further explored by the cosmetic and pharmaceutical industry. Additional research using travoprost and latanoprost as agents for eyelash growth should be performed in the future using prolonged treatment periods to determinate whether or not these PGA induce eyelash growth, and investigate other possible side effects.
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E001466.Full.Pdf
Editorial BMJ Glob Health: first published as 10.1136/bmjgh-2019-001466 on 11 April 2019. Downloaded from WHO recommendations on uterotonics for postpartum haemorrhage prevention: what works, and which one? Joshua P Vogel, 1,2 Myfanwy Williams,3 Ioannis Gallos,4 Fernando Althabe,1 Olufemi T Oladapo1 To cite: Vogel JP, THE GLOBAL BURDEN OF POSTPARTUM trials of tranexamic acid for PPH treatment Williams M, Gallos I, et al. HAEMORRHAGE and a heat-stable formulation of carbetocin WHO recommendations on 6–12 uterotonics for postpartum Obstetric haemorrhage, especially post- for PPH prevention. The increasing haemorrhage prevention: partum haemorrhage (PPH), was responsible number of PPH prevention and management what works, and which for more than a quarter of the estimated 303 options makes it challenging for providers one?BMJ Glob Health 000 maternal deaths that occurred globally in and health system stakeholders to choose 2019;4:e001466. doi:10.1136/ 2015.1 PPH—commonly defined as a blood where and how to invest limited resources in bmjgh-2019-001466 loss of 500 mL or more within 24 hours after order to optimise health outcomes. birth—affects about 6% of all women giving Multiple uterotonics have been eval- Handling editor Seye Abimbola birth.1 Uterine atony is the most common uated for PPH prevention over the past Received 4 February 2019 cause of PPH, but it can also be caused by four decades, including oxytocin receptor Revised 10 March 2019 genital tract trauma, retained placental tissue agonists (oxytocin and carbetocin), prosta- Accepted 16 March 2019 or maternal bleeding disorders. The majority glandin analogues (misoprostol, sulprostone, of women who experience PPH have no iden- carboprost), ergot alkaloids (such as ergo- tifiable risk factor, meaning that PPH preven- metrine/methylergometrine) and combina- tion programmes rely on universal use of PPH tions of these (oxytocin plus ergometrine, © Author(s) (or their prophylaxis for all women in the immediate or oxytocin plus misoprostol).
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New Zealand Data Sheet
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Effect of Bimatoprost on Intraocular Pressure in Prostaglandin FP Receptor Knockout Mice
Effect of Bimatoprost on Intraocular Pressure in Prostaglandin FP Receptor Knockout Mice Jonathan G. Crowston,1 James D. Lindsey,1 Christy A. Morris,1 Larry Wheeler,2 Felipe A. Medeiros,1 and Robert N. Weinreb1 PURPOSE. To determine the effect of bimatoprost on intraocular ing are not known, it has been suggested that bimatoprost pressure in the prostaglandin FP receptor knockout mouse. fundamentally differs from latanoprost, by lowering IOP ETHODS ␮ ␮ through mechanisms that are independent of FP receptor sig- M . The IOP response to a single 1.2- g(4 L) dose of 5 bimatoprost was measured in the treated and untreated fellow naling. However, there is considerable controversy regarding eyes of homozygote (FPϩ/ϩ, n ϭ 9) and heterozygote (FPϮ, n the role of FP receptor signaling, because bimatoprost has ϭ been shown to bind and activate the FP receptor in cultured 10) FP-knockout mice, as well as in wild-type C57BL/6 mice 6 (FPϩ/ϩ, n ϭ 20). Serial IOP measurements were also per- human trabecular meshwork and human ciliary muscle cells. Measurement of aqueous humor dynamics in the mouse eye formed after topical bimatoprost in a separate generation of 7 homozygous FP-knockout mice and wild-type littermate con- has been detailed recently. The FP knockout mouse, gener- trol animals (n ϭ 4 per group). Aqueous humor protein ated by homologous translocation with a target vector that ␤ concentrations were measured to establish the state of the replaces the second exon of the FP gene with the -galactosi- blood–aqueous barrier. Tissue, aqueous humor and vitreous dase and neomycin-resistance gene, was produced to demon- strate the critical role of the interaction of PGF2␣ with FP concentrations of bimatoprost, latanoprost, and their C-1 free 8 acids were determined by liquid chromatography and tandem receptors in the initiation of parturition in pregnant mice.
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Product Monograph
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Preparation and Chiral HPLC Separation of the Enantiomeric Forms of Natural Prostaglandins
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Postpartum Haemorrhage
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New Zealand Data Sheet 1. Product Name 2. Qualitative
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Treatment of Eyebrow Hypotrichosis Using Bimatoprost: a Randomized, Double-Blind, Vehicle-Controlled Pilot Study
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API Manufacturing
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Disruption of Protein-Protein Interactions
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